ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.14609865
2	L-phenylalanine catabolic process (GO:0006559)	7.14609865
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.88668919
4	L-phenylalanine metabolic process (GO:0006558)	6.88668919
5	negative regulation of protein activation cascade (GO:2000258)	6.36459290
6	aromatic amino acid family catabolic process (GO:0009074)	6.35111133
7	negative regulation of complement activation (GO:0045916)	6.17419862
8	regulation of protein activation cascade (GO:2000257)	5.93883205
9	regulation of complement activation (GO:0030449)	5.74383864
10	indole-containing compound catabolic process (GO:0042436)	5.72847731
11	indolalkylamine catabolic process (GO:0046218)	5.72847731
12	tryptophan catabolic process (GO:0006569)	5.72847731
13	glyoxylate metabolic process (GO:0046487)	5.71853463
14	kynurenine metabolic process (GO:0070189)	5.71153033
15	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.66405048
16	cysteine metabolic process (GO:0006534)	5.46405243
17	bile acid biosynthetic process (GO:0006699)	5.39069885
18	tryptophan metabolic process (GO:0006568)	5.34073182
19	sulfur amino acid catabolic process (GO:0000098)	5.26111745
20	negative regulation of fibrinolysis (GO:0051918)	5.21021912
21	protein carboxylation (GO:0018214)	5.15060974
22	peptidyl-glutamic acid carboxylation (GO:0017187)	5.15060974
23	alpha-linolenic acid metabolic process (GO:0036109)	5.11059695
24	high-density lipoprotein particle remodeling (GO:0034375)	4.96504040
25	urea cycle (GO:0000050)	4.93936966
26	urea metabolic process (GO:0019627)	4.93936966
27	regulation of fibrinolysis (GO:0051917)	4.92309371
28	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.84534705
29	serine family amino acid catabolic process (GO:0009071)	4.82482648
30	lysine catabolic process (GO:0006554)	4.71289062
31	lysine metabolic process (GO:0006553)	4.71289062
32	complement activation, alternative pathway (GO:0006957)	4.60898686
33	bile acid metabolic process (GO:0008206)	4.59361476
34	aromatic amino acid family metabolic process (GO:0009072)	4.57489907
35	nitrogen cycle metabolic process (GO:0071941)	4.55213874
36	homocysteine metabolic process (GO:0050667)	4.43570905
37	regulation of cholesterol esterification (GO:0010872)	4.39133692
38	reverse cholesterol transport (GO:0043691)	4.35589681
39	alpha-amino acid catabolic process (GO:1901606)	4.34898452
40	regulation of triglyceride catabolic process (GO:0010896)	4.33745009
41	cellular ketone body metabolic process (GO:0046950)	4.31607916
42	blood coagulation, intrinsic pathway (GO:0007597)	4.30489291
43	amino-acid betaine metabolic process (GO:0006577)	4.28597150
44	intestinal cholesterol absorption (GO:0030299)	4.24753325
45	fibrinolysis (GO:0042730)	4.22605877
46	tyrosine metabolic process (GO:0006570)	4.20851768
47	protein-lipid complex remodeling (GO:0034368)	4.18961959
48	macromolecular complex remodeling (GO:0034367)	4.18961959
49	plasma lipoprotein particle remodeling (GO:0034369)	4.18961959
50	acylglycerol homeostasis (GO:0055090)	4.16220174
51	triglyceride homeostasis (GO:0070328)	4.16220174
52	cellular modified amino acid catabolic process (GO:0042219)	4.15816995
53	glutamate metabolic process (GO:0006536)	4.13605959
54	serine family amino acid metabolic process (GO:0009069)	4.12540633
55	negative regulation of humoral immune response (GO:0002921)	4.12200400
56	coenzyme catabolic process (GO:0009109)	4.11671459
57	plasma lipoprotein particle clearance (GO:0034381)	4.08878514
58	cellular amino acid catabolic process (GO:0009063)	4.08718697
59	glycine metabolic process (GO:0006544)	4.08109888
60	cellular glucuronidation (GO:0052695)	4.07416773
61	negative regulation of sterol transport (GO:0032372)	4.05460757
62	negative regulation of cholesterol transport (GO:0032375)	4.05460757
63	serine family amino acid biosynthetic process (GO:0009070)	3.99829606
64	indolalkylamine metabolic process (GO:0006586)	3.96143232
65	cellular biogenic amine catabolic process (GO:0042402)	3.94984127
66	amine catabolic process (GO:0009310)	3.94984127
67	phospholipid efflux (GO:0033700)	3.93908621
68	complement activation, classical pathway (GO:0006958)	3.93461573
69	benzene-containing compound metabolic process (GO:0042537)	3.92266818
70	protein-lipid complex assembly (GO:0065005)	3.90508946
71	dicarboxylic acid biosynthetic process (GO:0043650)	3.89962321
72	bile acid and bile salt transport (GO:0015721)	3.89460201
73	ethanol oxidation (GO:0006069)	3.83672850
74	regulation of plasminogen activation (GO:0010755)	3.80773792
75	protein activation cascade (GO:0072376)	3.80528987
76	complement activation (GO:0006956)	3.77809735
77	cholesterol efflux (GO:0033344)	3.76415287
78	imidazole-containing compound metabolic process (GO:0052803)	3.74658457
79	drug catabolic process (GO:0042737)	3.74625150
80	proline metabolic process (GO:0006560)	3.71860138
81	ketone body metabolic process (GO:1902224)	3.71098693
82	very-low-density lipoprotein particle assembly (GO:0034379)	3.67371149
83	drug transmembrane transport (GO:0006855)	3.66476812
84	uronic acid metabolic process (GO:0006063)	3.65891903
85	glucuronate metabolic process (GO:0019585)	3.65891903
86	aldehyde catabolic process (GO:0046185)	3.62917246
87	aspartate family amino acid catabolic process (GO:0009068)	3.62329259
88	regulation of cholesterol homeostasis (GO:2000188)	3.62015629
89	organic acid catabolic process (GO:0016054)	3.59340738
90	carboxylic acid catabolic process (GO:0046395)	3.59340738
91	urate metabolic process (GO:0046415)	3.58752473
92	acetyl-CoA metabolic process (GO:0006084)	3.57584675
93	positive regulation of triglyceride lipase activity (GO:0061365)	3.56571105
94	positive regulation of lipoprotein lipase activity (GO:0051006)	3.56571105
95	arginine metabolic process (GO:0006525)	3.54599218
96	short-chain fatty acid metabolic process (GO:0046459)	3.54328081
97	cholesterol homeostasis (GO:0042632)	3.53589511
98	plasma lipoprotein particle assembly (GO:0034377)	3.51449530
99	phospholipid homeostasis (GO:0055091)	3.49683112
100	sterol homeostasis (GO:0055092)	3.49574594
101	regulation of apoptotic cell clearance (GO:2000425)	3.46331298
102	2-oxoglutarate metabolic process (GO:0006103)	3.45977532
103	fatty acid beta-oxidation (GO:0006635)	3.41947849
104	opsonization (GO:0008228)	3.41164434
105	proline biosynthetic process (GO:0006561)	3.40970974
106	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.40744416
107	low-density lipoprotein particle remodeling (GO:0034374)	3.39250157
108	cofactor catabolic process (GO:0051187)	3.39185069
109	fatty acid oxidation (GO:0019395)	3.36903277
110	L-alpha-amino acid transmembrane transport (GO:1902475)	3.36350256
111	oligosaccharide catabolic process (GO:0009313)	3.32987088
112	pinocytosis (GO:0006907)	3.27384310
113	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.22516714
114	plasma lipoprotein particle organization (GO:0071827)	3.21507929
115	GDP-mannose metabolic process (GO:0019673)	3.20227900
116	protein maturation by protein folding (GO:0022417)	3.20185490
117	hyaluronan catabolic process (GO:0030214)	3.20111538
118	4-hydroxyproline metabolic process (GO:0019471)	3.18562850
119	protein-lipid complex subunit organization (GO:0071825)	3.17885552
120	regulation of extracellular matrix disassembly (GO:0010715)	3.16549711
121	galactose catabolic process (GO:0019388)	3.13536370
122	Golgi transport vesicle coating (GO:0048200)	3.10579713
123	COPI coating of Golgi vesicle (GO:0048205)	3.10579713
124	negative regulation of hemostasis (GO:1900047)	3.06881314
125	negative regulation of blood coagulation (GO:0030195)	3.06881314
126	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.04185937
127	protein retention in ER lumen (GO:0006621)	3.01807085
128	acute-phase response (GO:0006953)	2.97007627
129	regulation of cholesterol biosynthetic process (GO:0045540)	2.92598683
130	negative regulation of coagulation (GO:0050819)	2.89553721
131	low-density lipoprotein particle clearance (GO:0034383)	2.82319164
132	glycosphingolipid catabolic process (GO:0046479)	2.78611080
133	purine ribonucleotide transport (GO:0015868)	2.76986449
134	regulation of cholesterol metabolic process (GO:0090181)	2.75851859
135	glycolipid catabolic process (GO:0019377)	2.74781146
136	positive regulation of blood coagulation (GO:0030194)	2.70790880
137	positive regulation of hemostasis (GO:1900048)	2.70790880
138	positive regulation of extracellular matrix organization (GO:1903055)	2.70248415
139	regulation of metalloenzyme activity (GO:0048552)	2.69700944
140	regulation of extracellular matrix organization (GO:1903053)	2.69480156
141	positive regulation of coagulation (GO:0050820)	2.68929596
142	regulation of fatty acid biosynthetic process (GO:0042304)	2.67060145
143	sphingolipid catabolic process (GO:0030149)	2.64198346
144	fat-soluble vitamin biosynthetic process (GO:0042362)	2.62160530
145	membrane lipid catabolic process (GO:0046466)	2.60504285
146	negative regulation of wound healing (GO:0061045)	2.59958900
147	positive regulation of steroid metabolic process (GO:0045940)	2.58635399
148	cholesterol transport (GO:0030301)	2.58006494
149	sterol transport (GO:0015918)	2.58006494
150	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.56613525
151	regulation of cholesterol storage (GO:0010885)	2.55973791
152	amino sugar catabolic process (GO:0046348)	2.55555752
153	NADH metabolic process (GO:0006734)	2.52075862
154	glycogen catabolic process (GO:0005980)	2.50360437
155	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.49801440
156	lipoprotein metabolic process (GO:0042157)	2.48808559
157	monosaccharide biosynthetic process (GO:0046364)	2.47580178
158	modified amino acid transport (GO:0072337)	2.45690521
159	L-serine metabolic process (GO:0006563)	2.45477768

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.79650457
2	PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.73580369
3	* LXR_22158963_ChIP-Seq_LIVER_Mouse	5.95848273
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	5.77305269
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.07096698
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.95251454
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.26027653
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.67987152
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.21915870
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.55168838
11	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.39414783
12	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.28336230
13	CLOCK_20551151_ChIP-Seq_293T_Human	2.03483302
14	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.03057645
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	10.8780934
16	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.97442845
17	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.86205513
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.83357296
19	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.79369381
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.78435947
21	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.63725195
22	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.59050814
23	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.57386978
24	P68_20966046_ChIP-Seq_HELA_Human	1.55789860
25	VDR_21846776_ChIP-Seq_THP-1_Human	1.51418071
26	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.49660585
27	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.48868977
28	BCOR_27268052_Chip-Seq_Bcells_Human	1.45646876
29	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.44874797
30	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.42445801
31	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.41336602
32	BCL6_27268052_Chip-Seq_Bcells_Human	1.40518075
33	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.34951309
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34653734
35	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.28754845
36	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.25281612
37	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.24810044
38	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.24191355
39	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.22661205
40	* RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.19653827
41	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.18312421
42	HTT_18923047_ChIP-ChIP_STHdh_Human	1.17405664
43	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.16950196
44	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.16191841
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15210550
46	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.14004726
47	* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.13623040
48	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.13162718
49	PHF8_20622854_ChIP-Seq_HELA_Human	1.12750839
50	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.11897950
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.11638407
52	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.11086286
53	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.11070727
54	* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.10063494
55	ZNF263_19887448_ChIP-Seq_K562_Human	1.09153625
56	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.09066875
57	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08103555
58	* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.07561683
59	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.07459829
60	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.06914217
61	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.06708288
62	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.06704013
63	E2F1_20622854_ChIP-Seq_HELA_Human	1.06401425
64	LXR_22292898_ChIP-Seq_THP-1_Human	1.06306820
65	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.05930800
66	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.05722615
67	CTCF_21964334_Chip-Seq_Bcells_Human	1.05319653
68	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.04680569
69	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.04632497
70	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.04445670
71	* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.03733935
72	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.03196008
73	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.03164160
74	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.02370749
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.02013736
76	SA1_27219007_Chip-Seq_Bcells_Human	1.01863605
77	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.01380197
78	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.00957826
79	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.00180623
80	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.99693047
81	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.99414940
82	SMC4_20622854_ChIP-Seq_HELA_Human	0.98676605
83	TP53_22127205_ChIP-Seq_IMR90_Human	0.98646501
84	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.98380144
85	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.97616320
86	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.97298371
87	* PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.96717207
88	TFEB_21752829_ChIP-Seq_HELA_Human	0.96157814
89	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.95489370
90	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.94523053
91	* MAF_26560356_Chip-Seq_TH2_Human	0.93910055
92	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.93120272
93	GATA4_25053715_ChIP-Seq_YYC3_Human	0.92263932
94	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.91514903
95	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.91443781
96	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91411553
97	GATA1_22025678_ChIP-Seq_K562_Human	0.86262797
98	RACK7_27058665_Chip-Seq_MCF-7_Human	0.86142371
99	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.85495907
100	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.80039669
101	EGR1_19032775_ChIP-ChIP_M12_Human	0.79553445
102	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.77982850
103	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.76736298
104	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.75451163
105	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.73721144
106	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.72989063
107	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.70696148
108	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.70628027
109	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.69065261
110	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.69065261
111	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.68966337
112	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.67792847
113	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.66627924
114	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.66353051
115	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.66353051
116	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.66091480
117	* RARB_24833708_ChIP-Seq_LIVER_Mouse	0.65723253
118	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.65555670
119	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.64771129
120	GATA1_19941826_ChIP-Seq_K562_Human	0.64198825
121	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.63366437
122	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.62479559
123	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.62027374
124	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.61846314
125	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.60718489
126	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.60183624
127	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.59970501
128	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.58982563
129	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.58807621
130	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.58616003
131	ATF3_27146783_Chip-Seq_COLON_Human	0.57953231
132	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.57851811
133	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.57193043
134	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.56466271
135	CTCF_27219007_Chip-Seq_Bcells_Human	0.56411513
136	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.55841341
137	SOX2_20726797_ChIP-Seq_SW620_Human	0.55488894
138	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.55301590
139	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.54824591
140	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.54738608
141	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.54026994
142	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.52512682
143	GATA6_25053715_ChIP-Seq_YYC3_Human	0.52498401
144	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.51648063
145	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.51574707
146	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.50879530
147	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.50058261
148	CEBPB_22108803_ChIP-Seq_LS180_Human	0.49709468
149	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.49157091
150	MYC_19915707_ChIP-ChIP_AK7_Human	0.49084631
151	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.47965748
152	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.47723901
153	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.47625967
154	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.47336859
155	CREB1_26743006_Chip-Seq_LNCaP_Human	0.46871387

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.62965630
2	MP0005360_urolithiasis	7.14624058
3	MP0005085_abnormal_gallbladder_physiolo	5.92761572
4	MP0005365_abnormal_bile_salt	5.78584671
5	MP0008875_abnormal_xenobiotic_pharmacok	4.52316970
6	MP0003806_abnormal_nucleotide_metabolis	4.18472221
7	MP0003252_abnormal_bile_duct	3.62986096
8	MP0009840_abnormal_foam_cell	3.60507603
9	MP0010329_abnormal_lipoprotein_level	3.39239875
10	MP0005083_abnormal_biliary_tract	3.05879316
11	MP0005332_abnormal_amino_acid	2.84872883
12	MP0003195_calcinosis	2.57996432
13	MP0001666_abnormal_nutrient_absorption	2.45084823
14	MP0008260_abnormal_autophagy	2.42431342
15	MP0002837_dystrophic_cardiac_calcinosis	2.34826043
16	MP0003191_abnormal_cellular_cholesterol	2.23307206
17	MP0000751_myopathy	2.20825096
18	MP0004019_abnormal_vitamin_homeostasis	2.12122809
19	MP0002118_abnormal_lipid_homeostasis	1.98711668
20	MP0000609_abnormal_liver_physiology	1.98402340
21	MP0003705_abnormal_hypodermis_morpholog	1.83426084
22	MP0004233_abnormal_muscle_weight	1.81471544
23	MP0005319_abnormal_enzyme/_coenzyme	1.78106759
24	MP0002132_abnormal_respiratory_system	1.72866357
25	MP0002138_abnormal_hepatobiliary_system	1.72733494
26	MP0005257_abnormal_intraocular_pressure	1.64007005
27	MP0005584_abnormal_enzyme/coenzyme_acti	1.59035485
28	MP0003122_maternal_imprinting	1.58115080
29	MP0009643_abnormal_urine_homeostasis	1.44605379
30	MP0003868_abnormal_feces_composition	1.40977001
31	MP0008438_abnormal_cutaneous_collagen	1.40490860
32	MP0000747_muscle_weakness	1.37642478
33	MP0005451_abnormal_body_composition	1.36386218
34	MP0005410_abnormal_fertilization	1.33625269
35	MP0003186_abnormal_redox_activity	1.32865635
36	MP0010368_abnormal_lymphatic_system	1.25748363
37	MP0006082_CNS_inflammation	1.23543154
38	MP0005167_abnormal_blood-brain_barrier	1.22671416
39	MP0000604_amyloidosis	1.21579042
40	MP0001764_abnormal_homeostasis	1.20736797
41	MP0003436_decreased_susceptibility_to	1.19530942
42	MP0001849_ear_inflammation	1.17671218
43	MP0003075_altered_response_to	1.16815948
44	MP0000598_abnormal_liver_morphology	1.16318489
45	MP0003011_delayed_dark_adaptation	1.16008028
46	MP0002089_abnormal_postnatal_growth/wei	1.15942440
47	MP0010030_abnormal_orbit_morphology	1.14533349
48	MP0005636_abnormal_mineral_homeostasis	1.13104946
49	MP0005670_abnormal_white_adipose	1.11898529
50	MP0001915_intracranial_hemorrhage	1.11296471
51	MP0005058_abnormal_lysosome_morphology	1.10515148
52	MP0009697_abnormal_copulation	1.08296739
53	MP0003656_abnormal_erythrocyte_physiolo	1.04028259
54	MP0003123_paternal_imprinting	1.03119758
55	MP0005464_abnormal_platelet_physiology	1.02535077
56	MP0005377_hearing/vestibular/ear_phenot	1.00617296
57	MP0003878_abnormal_ear_physiology	1.00617296
58	MP0003566_abnormal_cell_adhesion	0.98382053
59	MP0003646_muscle_fatigue	0.97821975
60	MP0005084_abnormal_gallbladder_morpholo	0.95645246
61	MP0000750_abnormal_muscle_regeneration	0.94480688
62	MP0000003_abnormal_adipose_tissue	0.94440043
63	MP0006036_abnormal_mitochondrial_physio	0.92979291
64	MP0009780_abnormal_chondrocyte_physiolo	0.92801039
65	MP0000858_altered_metastatic_potential	0.91581232
66	MP0002254_reproductive_system_inflammat	0.91374166
67	MP0003879_abnormal_hair_cell	0.90296936
68	MP0001533_abnormal_skeleton_physiology	0.88792203
69	MP0002998_abnormal_bone_remodeling	0.86590057
70	MP0009763_increased_sensitivity_to	0.84048832
71	MP0005376_homeostasis/metabolism_phenot	0.83924765
72	MP0002269_muscular_atrophy	0.82390561
73	MP0009764_decreased_sensitivity_to	0.82041545
74	MP0009642_abnormal_blood_homeostasis	0.80674449
75	MP0002933_joint_inflammation	0.80173336
76	MP0004130_abnormal_muscle_cell	0.79957713
77	MP0000343_altered_response_to	0.79159887
78	MP0000767_abnormal_smooth_muscle	0.78942790
79	MP0000759_abnormal_skeletal_muscle	0.78617122
80	MP0005647_abnormal_sex_gland	0.77881581
81	MP0002419_abnormal_innate_immunity	0.77617266
82	MP0001756_abnormal_urination	0.76105768
83	MP0004087_abnormal_muscle_fiber	0.75044179
84	MP0005408_hypopigmentation	0.74267412
85	MP0005266_abnormal_metabolism	0.73904264
86	MP0008469_abnormal_protein_level	0.73800981
87	MP0005220_abnormal_exocrine_pancreas	0.73396941
88	MP0002971_abnormal_brown_adipose	0.73127851
89	MP0000013_abnormal_adipose_tissue	0.72817510
90	MP0002106_abnormal_muscle_physiology	0.72683878
91	MP0002078_abnormal_glucose_homeostasis	0.72294681
92	MP0000678_abnormal_parathyroid_gland	0.70260953
93	MP0000639_abnormal_adrenal_gland	0.68696954
94	MP0005375_adipose_tissue_phenotype	0.65701548
95	MP0003329_amyloid_beta_deposits	0.65366875
96	MP0009053_abnormal_anal_canal	0.63894357
97	MP0004084_abnormal_cardiac_muscle	0.63823731
98	MP0003453_abnormal_keratinocyte_physiol	0.63472027
99	MP0005369_muscle_phenotype	0.62828705
100	MP0004036_abnormal_muscle_relaxation	0.60582584
101	MP0002136_abnormal_kidney_physiology	0.60577575
102	MP0001853_heart_inflammation	0.59820278
103	MP0005666_abnormal_adipose_tissue	0.59011982
104	MP0002896_abnormal_bone_mineralization	0.58484019
105	MP0005334_abnormal_fat_pad	0.57692548
106	MP0006138_congestive_heart_failure	0.57270968
107	MP0006035_abnormal_mitochondrial_morpho	0.56135186
108	MP0003690_abnormal_glial_cell	0.55585008
109	MP0006054_spinal_hemorrhage	0.54765411
110	MP0005330_cardiomyopathy	0.54142593
111	MP0000749_muscle_degeneration	0.54122126
112	MP0009384_cardiac_valve_regurgitation	0.53927371
113	MP0001542_abnormal_bone_strength	0.52789608
114	MP0009765_abnormal_xenobiotic_induced	0.52559835
115	MP0004185_abnormal_adipocyte_glucose	0.49190133
116	MP0005535_abnormal_body_temperature	0.48579787
117	MP0001958_emphysema	0.48564675
118	MP0005164_abnormal_response_to	0.48487339
119	MP0005395_other_phenotype	0.48230520
120	MP0001661_extended_life_span	0.47612000
121	MP0000249_abnormal_blood_vessel	0.46244444
122	MP0005023_abnormal_wound_healing	0.45691173
123	MP0002796_impaired_skin_barrier	0.45417339
124	MP0002295_abnormal_pulmonary_circulatio	0.43980899
125	MP0003279_aneurysm	0.42952851
126	MP0003638_abnormal_response/metabolism_	0.42003915
127	MP0004043_abnormal_pH_regulation	0.41719789
128	MP0004883_abnormal_blood_vessel	0.41504233
129	MP0002060_abnormal_skin_morphology	0.41462385
130	MP0004264_abnormal_extraembryonic_tissu	0.40723676
131	MP0004272_abnormal_basement_membrane	0.39667034
132	MP0001765_abnormal_ion_homeostasis	0.39169807
133	MP0003172_abnormal_lysosome_physiology	0.39043919
134	MP0009672_abnormal_birth_weight	0.38991582
135	MP0001879_abnormal_lymphatic_vessel	0.38719193
136	MP0003718_maternal_effect	0.38613511
137	MP0002876_abnormal_thyroid_physiology	0.37808356
138	MP0000538_abnormal_urinary_bladder	0.37505039
139	MP0002168_other_aberrant_phenotype	0.36221802
140	MP0001243_abnormal_dermal_layer	0.36149901
141	MP0003953_abnormal_hormone_level	0.35827910
142	MP0005595_abnormal_vascular_smooth	0.34781037
143	MP0002135_abnormal_kidney_morphology	0.34145955

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	6.91006477
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.76119641
3	Intrahepatic cholestasis (HP:0001406)	6.70634576
4	Xanthomatosis (HP:0000991)	6.03923979
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.90929069
6	Prolonged partial thromboplastin time (HP:0003645)	5.48822057
7	Hypobetalipoproteinemia (HP:0003563)	5.48260475
8	Hyperlipoproteinemia (HP:0010980)	5.16886263
9	Complement deficiency (HP:0004431)	4.57818519
10	Hypolipoproteinemia (HP:0010981)	4.49888298
11	Hyperammonemia (HP:0001987)	4.39369202
12	Hypoalphalipoproteinemia (HP:0003233)	4.27420596
13	Systemic lupus erythematosus (HP:0002725)	4.26399002
14	Hyperglycinemia (HP:0002154)	4.18841177
15	Ketosis (HP:0001946)	4.17681885
16	Abnormality of the common coagulation pathway (HP:0010990)	4.15207962
17	Joint hemorrhage (HP:0005261)	4.10739931
18	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.09527343
19	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.98517595
20	Hyperglycinuria (HP:0003108)	3.91122280
21	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.89781098
22	Abnormality of serine family amino acid metabolism (HP:0010894)	3.87563446
23	Abnormality of glycine metabolism (HP:0010895)	3.87563446
24	Hypoglycemic coma (HP:0001325)	3.83337511
25	Abnormality of mucopolysaccharide metabolism (HP:0011020)	3.79264499
26	Abnormality of polysaccharide metabolism (HP:0011012)	3.79264499
27	Abnormality of glycosaminoglycan metabolism (HP:0004371)	3.79264499
28	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.72092905
29	Vacuolated lymphocytes (HP:0001922)	3.70533391
30	Epidermoid cyst (HP:0200040)	3.67783088
31	Abnormality of the intrinsic pathway (HP:0010989)	3.67496360
32	Urinary glycosaminoglycan excretion (HP:0003541)	3.67177825
33	Mucopolysacchariduria (HP:0008155)	3.67177825
34	Fat malabsorption (HP:0002630)	3.66445057
35	Abnormality of glycolipid metabolism (HP:0010969)	3.64385457
36	Abnormality of liposaccharide metabolism (HP:0010968)	3.64385457
37	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.64385457
38	Glomerulonephritis (HP:0000099)	3.60164730
39	Abnormality of fatty-acid metabolism (HP:0004359)	3.55419065
40	Abnormality of methionine metabolism (HP:0010901)	3.53704533
41	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.33531151
42	Conjugated hyperbilirubinemia (HP:0002908)	3.29492707
43	Dysostosis multiplex (HP:0000943)	3.25591190
44	Abnormality of complement system (HP:0005339)	3.25317592
45	Ketoacidosis (HP:0001993)	3.11628159
46	Hypercholesterolemia (HP:0003124)	3.08197225
47	Gout (HP:0001997)	3.05002027
48	Abnormality of pyrimidine metabolism (HP:0004353)	3.01719158
49	Hyperbilirubinemia (HP:0002904)	3.00456911
50	Asymmetric septal hypertrophy (HP:0001670)	2.96324967
51	Nuclear cataract (HP:0100018)	2.94211900
52	Abnormality of nucleobase metabolism (HP:0010932)	2.94153012
53	Delayed CNS myelination (HP:0002188)	2.91320688
54	Abnormality of purine metabolism (HP:0004352)	2.90369940
55	Hemorrhage of the eye (HP:0011885)	2.84320466
56	Vertebral compression fractures (HP:0002953)	2.83669810
57	Abnormality of serum amino acid levels (HP:0003112)	2.81948582
58	Spontaneous abortion (HP:0005268)	2.81086631
59	Nemaline bodies (HP:0003798)	2.76896883
60	Myocardial infarction (HP:0001658)	2.74082772
61	Ulnar deviation of the wrist (HP:0003049)	2.73914012
62	Loss of speech (HP:0002371)	2.72117422
63	Hepatocellular carcinoma (HP:0001402)	2.69967648
64	Skin nodule (HP:0200036)	2.68678771
65	Exercise-induced myalgia (HP:0003738)	2.67804795
66	Steatorrhea (HP:0002570)	2.64958103
67	Prolonged neonatal jaundice (HP:0006579)	2.64404105
68	Cervical subluxation (HP:0003308)	2.64052336
69	Metabolic acidosis (HP:0001942)	2.61454769
70	Vascular calcification (HP:0004934)	2.60142823
71	Right ventricular cardiomyopathy (HP:0011663)	2.58890316
72	Turricephaly (HP:0000262)	2.57497435
73	Dicarboxylic aciduria (HP:0003215)	2.57037762
74	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.57037762
75	Muscle fiber inclusion bodies (HP:0100299)	2.54581386
76	Gingival bleeding (HP:0000225)	2.54323918
77	Lethargy (HP:0001254)	2.47853758
78	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.45916557
79	Sensorimotor neuropathy (HP:0007141)	2.45859865
80	Generalized aminoaciduria (HP:0002909)	2.45787923
81	Protrusio acetabuli (HP:0003179)	2.44524954
82	Malnutrition (HP:0004395)	2.42756553
83	Cardiovascular calcification (HP:0011915)	2.40302761
84	Myopathic facies (HP:0002058)	2.39722954
85	Distal lower limb muscle weakness (HP:0009053)	2.39513919
86	Neonatal onset (HP:0003623)	2.33605456
87	Hypoglycemic seizures (HP:0002173)	2.32306651
88	Reduced antithrombin III activity (HP:0001976)	2.32265146
89	Progressive neurologic deterioration (HP:0002344)	2.29679871
90	J-shaped sella turcica (HP:0002680)	2.28387152
91	Spastic diplegia (HP:0001264)	2.28264124
92	Mitral stenosis (HP:0001718)	2.27910824
93	Vomiting (HP:0002013)	2.26775389
94	Abnormal gallbladder morphology (HP:0012437)	2.25968721
95	Cholelithiasis (HP:0001081)	2.24628674
96	Abnormal cartilage morphology (HP:0002763)	2.24491001
97	Abnormality of macrophages (HP:0004311)	2.21973422
98	Abnormality of the Achilles tendon (HP:0005109)	2.21551552
99	Esophageal varix (HP:0002040)	2.21247941
100	Irritability (HP:0000737)	2.19806163
101	Hypochromic microcytic anemia (HP:0004840)	2.19330465
102	Proximal tubulopathy (HP:0000114)	2.15475463
103	Type I transferrin isoform profile (HP:0003642)	2.14316569
104	Cerebral edema (HP:0002181)	2.13405718
105	Cholecystitis (HP:0001082)	2.11975675
106	Abnormal gallbladder physiology (HP:0012438)	2.11975675
107	Joint stiffness (HP:0001387)	2.11741864
108	Abnormality of proline metabolism (HP:0010907)	2.09582672
109	Hydroxyprolinuria (HP:0003080)	2.09582672
110	Late onset (HP:0003584)	2.07819650
111	Amyloidosis (HP:0011034)	2.06764330
112	Menorrhagia (HP:0000132)	2.06627605
113	Increased purine levels (HP:0004368)	2.06290976
114	Hyperuricemia (HP:0002149)	2.06290976
115	Opisthotonus (HP:0002179)	2.06097290
116	Rhabdomyolysis (HP:0003201)	2.03737502
117	Increased serum ferritin (HP:0003281)	2.02194060
118	Hyperinsulinemic hypoglycemia (HP:0000825)	2.01969473
119	Pancreatitis (HP:0001733)	2.01134261
120	Rickets (HP:0002748)	2.00808580
121	Enlarged kidneys (HP:0000105)	1.97590501
122	Brushfield spots (HP:0001088)	1.96935007
123	Abnormality of transition element cation homeostasis (HP:0011030)	1.95637374
124	Type 1 muscle fiber predominance (HP:0003803)	1.95506460
125	Lymphangioma (HP:0100764)	1.93841611
126	Purpura (HP:0000979)	1.92621908
127	Polycythemia (HP:0001901)	1.91993773
128	Abnormal enzyme/coenzyme activity (HP:0012379)	1.88940594
129	Hypophosphatemic rickets (HP:0004912)	1.88219769
130	Abnormality of iron homeostasis (HP:0011031)	1.87810456
131	Bulbar palsy (HP:0001283)	1.87228911
132	Nephritis (HP:0000123)	1.87151189
133	Premature rupture of membranes (HP:0001788)	1.86906797
134	Abnormality of alkaline phosphatase activity (HP:0004379)	1.86312720
135	Alkalosis (HP:0001948)	1.85843502
136	Back pain (HP:0003418)	1.85538703
137	Increased cerebral lipofuscin (HP:0011813)	1.84555867
138	Glycosuria (HP:0003076)	1.83153048
139	Abnormality of urine glucose concentration (HP:0011016)	1.83153048
140	Easy fatigability (HP:0003388)	1.82515173
141	Hand muscle atrophy (HP:0009130)	1.82188898
142	Achilles tendon contracture (HP:0001771)	1.81895987
143	Vaginal fistula (HP:0004320)	1.81668418
144	Ragged-red muscle fibers (HP:0003200)	1.81340104
145	Metaphyseal irregularity (HP:0003025)	1.81091260
146	Ovoid vertebral bodies (HP:0003300)	1.80441934
147	Abnormality of the gallbladder (HP:0005264)	1.80366707
148	Axonal loss (HP:0003447)	1.80320819
149	Elevated alkaline phosphatase (HP:0003155)	1.80194289
150	Confusion (HP:0001289)	1.79059571
151	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78209304
152	Abnormal protein N-linked glycosylation (HP:0012347)	1.78209304
153	Abnormal protein glycosylation (HP:0012346)	1.78209304
154	Abnormal glycosylation (HP:0012345)	1.78209304
155	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.77651353
156	Thrombophlebitis (HP:0004418)	1.77608161
157	Distal upper limb amyotrophy (HP:0007149)	1.76524116
158	Upper limb amyotrophy (HP:0009129)	1.76524116
159	Abnormality of carpal bone ossification (HP:0006257)	1.75774324
160	Malignant hyperthermia (HP:0002047)	1.75198608
161	Cerebral aneurysm (HP:0004944)	1.73372736
162	Myoglobinuria (HP:0002913)	1.71764261
163	Generalized amyotrophy (HP:0003700)	1.69257175
164	Beaking of vertebral bodies (HP:0004568)	1.68628258

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	6.21771158
2	ERN1	5.69252528
3	MUSK	5.17654389
4	SIK1	3.94988008
5	FGFR4	3.43993996
6	TRIB3	3.22934003
7	TESK1	2.85451896
8	IRAK3	2.67145223
9	PKN2	2.65466889
10	TESK2	2.42241175
11	TAOK3	2.11857106
12	ERBB4	1.91234537
13	MAPKAPK3	1.88950347
14	PIM2	1.74420840
15	BRAF	1.70955667
16	INSRR	1.70788606
17	BMX	1.68766820
18	LIMK1	1.68519811
19	LATS1	1.63942980
20	NME2	1.55568562
21	STK38L	1.55193111
22	ABL2	1.53430796
23	PTK6	1.45519295
24	MAP3K7	1.39540302
25	MAP2K3	1.38922075
26	PINK1	1.38152721
27	STK16	1.37410722
28	PIK3CG	1.35828594
29	MAP2K4	1.35177886
30	FGFR2	1.33461829
31	MAP2K2	1.32254765
32	MAPK11	1.31729730
33	NEK9	1.28652818
34	MAP3K1	1.28621392
35	MST1R	1.26685016
36	MAP3K3	1.26414069
37	MAP3K11	1.25761832
38	EPHB2	1.24612791
39	KDR	1.21550762
40	MAPK12	1.21326999
41	LATS2	1.16621496
42	ZAP70	1.14490315
43	VRK2	1.13741336
44	PDPK1	1.11513805
45	PDGFRA	1.11466155
46	FGFR1	1.10662385
47	MATK	1.10600840
48	SIK3	1.07438497
49	PAK4	1.05871349
50	TGFBR2	1.04915295
51	PRKD2	1.02437371
52	FGFR3	0.96326701
53	TAOK2	0.95022584
54	CSF1R	0.93309141
55	FLT3	0.92805804
56	MAP2K6	0.91532067
57	PTK2	0.89697597
58	ICK	0.88487434
59	TYK2	0.87431595
60	DYRK1B	0.84313555
61	MET	0.81058218
62	ARAF	0.79710149
63	TTN	0.79649364
64	PDK2	0.78869874
65	MAP3K13	0.78648399
66	TBK1	0.73761531
67	BLK	0.73323377
68	PRKAA2	0.72635045
69	FGR	0.71787213
70	CDC42BPA	0.71304156
71	NME1	0.70163702
72	TIE1	0.69389995
73	KSR2	0.67761813
74	WNK4	0.67362763
75	MAP4K1	0.67051469
76	MOS	0.65596334
77	JAK2	0.64753994
78	MAP3K8	0.64177241
79	TAOK1	0.62980449
80	MAP3K10	0.62764498
81	MAP2K1	0.62523610
82	MTOR	0.61910617
83	GSK3A	0.61203333
84	MAPK4	0.61057285
85	EPHB1	0.60795966
86	DAPK2	0.60770102
87	PDK1	0.60360025
88	GRK6	0.59497715
89	RIPK1	0.58734294
90	MYLK	0.58197861
91	CSK	0.57495521
92	CAMK2G	0.57327333
93	ERBB2	0.57304363
94	PRKCZ	0.57106355
95	EPHA3	0.56221678
96	MAP3K6	0.56093376
97	CDK6	0.54510888
98	LRRK2	0.54457477
99	PRKAA1	0.54138386
100	PAK3	0.53983501
101	JAK3	0.53643828
102	PRKG2	0.53442500
103	ILK	0.53390123
104	CDK7	0.52704686
105	RPS6KA2	0.50815603
106	EPHA2	0.50024771
107	OBSCN	0.48271930
108	PRKD1	0.47945451
109	STK38	0.47714516
110	PRKD3	0.47001106
111	ROCK2	0.46183099
112	ROCK1	0.45773870
113	PDK3	0.45555164
114	PDK4	0.45555164
115	TYRO3	0.45153708
116	PRKACG	0.44754311
117	MAP3K5	0.41308063
118	IKBKB	0.41075835
119	PHKG1	0.40477136
120	PHKG2	0.40477136
121	FER	0.40460709
122	MAP3K14	0.40136029
123	CSNK1G1	0.39909046
124	LMTK2	0.39535364
125	AKT2	0.39375332
126	TNK2	0.39181999
127	DDR2	0.39175209
128	IKBKE	0.38308010
129	MAPK7	0.37728310
130	PRPF4B	0.35372692
131	IGF1R	0.35018161
132	RET	0.31163882
133	PIK3CA	0.30850147
134	CDK12	0.30536313
135	MAPKAPK2	0.30412202
136	SGK494	0.29799785
137	SGK223	0.29799785
138	MARK2	0.29702271
139	EGFR	0.29630158
140	TRIM28	0.29526748
141	RPS6KL1	0.27032891
142	RPS6KC1	0.27032891
143	SMG1	0.26431676
144	CDK9	0.25044255

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.19173161
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.46038625
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.39539930
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.30920643
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.89848257
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.83592240
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.80503464
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.73591535
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.55589733
10	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.51312029
11	Fatty acid degradation_Homo sapiens_hsa00071	2.49980387
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.43571636
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.24883927
14	Butanoate metabolism_Homo sapiens_hsa00650	2.19404301
15	Histidine metabolism_Homo sapiens_hsa00340	2.12463471
16	Peroxisome_Homo sapiens_hsa04146	2.06943550
17	Propanoate metabolism_Homo sapiens_hsa00640	1.97842762
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.92364186
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.85945292
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.84347790
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.80278755
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.77962077
23	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.76477050
24	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.72457864
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.69698901
26	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.65218518
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.62998892
28	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.61122097
29	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.57345786
30	Retinol metabolism_Homo sapiens_hsa00830	1.50733555
31	Caffeine metabolism_Homo sapiens_hsa00232	1.50334304
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47230004
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.45053868
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.43824930
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.42929757
36	Bile secretion_Homo sapiens_hsa04976	1.40500370
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.36409671
38	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.33478564
39	Sulfur metabolism_Homo sapiens_hsa00920	1.33074418
40	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.32495997
41	Arginine and proline metabolism_Homo sapiens_hsa00330	1.30359089
42	Tyrosine metabolism_Homo sapiens_hsa00350	1.27906759
43	Fat digestion and absorption_Homo sapiens_hsa04975	1.27272298
44	Carbon metabolism_Homo sapiens_hsa01200	1.25153870
45	Fatty acid elongation_Homo sapiens_hsa00062	1.24025411
46	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.22450551
47	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.21968572
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21966392
49	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.17574615
50	Folate biosynthesis_Homo sapiens_hsa00790	1.17485001
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11121040
52	Steroid biosynthesis_Homo sapiens_hsa00100	1.08361681
53	Sulfur relay system_Homo sapiens_hsa04122	1.01216000
54	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.97295346
55	Glutathione metabolism_Homo sapiens_hsa00480	0.96402413
56	Pertussis_Homo sapiens_hsa05133	0.96006206
57	ABC transporters_Homo sapiens_hsa02010	0.95306508
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91163113
59	Proteasome_Homo sapiens_hsa03050	0.90822705
60	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.88989267
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.88787955
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86561060
63	Lysine degradation_Homo sapiens_hsa00310	0.80428458
64	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.76130465
65	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.75609816
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71265382
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65690776
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.65004743
69	Vibrio cholerae infection_Homo sapiens_hsa05110	0.62481401
70	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.59338782
71	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.56815771
72	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.55895922
73	One carbon pool by folate_Homo sapiens_hsa00670	0.54535594
74	Metabolic pathways_Homo sapiens_hsa01100	0.50012390
75	Prion diseases_Homo sapiens_hsa05020	0.48824006
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.48105722
77	Legionellosis_Homo sapiens_hsa05134	0.46183848
78	Renin-angiotensin system_Homo sapiens_hsa04614	0.42349485
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41968223
80	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.36990716
81	Galactose metabolism_Homo sapiens_hsa00052	0.36854235
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35180402
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31811480
84	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.31238566
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30917629
86	Circadian rhythm_Homo sapiens_hsa04710	0.28300101
87	RNA polymerase_Homo sapiens_hsa03020	0.27514087
88	Insulin resistance_Homo sapiens_hsa04931	0.27506971
89	Base excision repair_Homo sapiens_hsa03410	0.27346807
90	Mineral absorption_Homo sapiens_hsa04978	0.26057264
91	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.24836225
92	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.23560298
93	Phagosome_Homo sapiens_hsa04145	0.21919774
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.21251479
95	Rheumatoid arthritis_Homo sapiens_hsa05323	0.20945714
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.18079161
97	Glucagon signaling pathway_Homo sapiens_hsa04922	0.12423618
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.10791094
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.09508565
100	Lysosome_Homo sapiens_hsa04142	0.07601964
101	AMPK signaling pathway_Homo sapiens_hsa04152	0.05931389
102	Regulation of autophagy_Homo sapiens_hsa04140	0.03473965
103	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.00730008
104	Protein digestion and absorption_Homo sapiens_hsa04974	-0.1566220
105	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	-0.1539501
106	ECM-receptor interaction_Homo sapiens_hsa04512	-0.1352879
107	Amoebiasis_Homo sapiens_hsa05146	-0.1180113
108	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.1079685
109	Ether lipid metabolism_Homo sapiens_hsa00565	-0.0942692
110	Other glycan degradation_Homo sapiens_hsa00511	-0.0756954
111	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.0703858
112	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.0681250
113	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.0531053
114	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0433525
115	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0430853
116	Bladder cancer_Homo sapiens_hsa05219	-0.0406905
117	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.0294040
118	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0003261

TMEM150A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »