TMEM150B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.73739868
2presynaptic membrane assembly (GO:0097105)5.43676350
3negative regulation of interleukin-12 production (GO:0032695)5.12325470
4presynaptic membrane organization (GO:0097090)4.85597085
5axon ensheathment in central nervous system (GO:0032291)4.70582903
6central nervous system myelination (GO:0022010)4.70582903
7response to peptidoglycan (GO:0032494)4.47131127
8vocalization behavior (GO:0071625)4.37292933
9neuronal action potential propagation (GO:0019227)4.36042598
10regulation of vitamin D biosynthetic process (GO:0060556)4.24495025
11short-term memory (GO:0007614)4.22998270
12immunoglobulin mediated immune response (GO:0016064)4.20908922
13macrophage activation involved in immune response (GO:0002281)4.05739729
14positive regulation of synapse assembly (GO:0051965)4.04349762
15neutrophil activation involved in immune response (GO:0002283)4.03820140
16positive regulation of gamma-delta T cell activation (GO:0046645)4.02027322
17postsynaptic membrane organization (GO:0001941)4.00569540
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.00234870
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.98970709
20regulation of podosome assembly (GO:0071801)3.98710367
21neuron recognition (GO:0008038)3.95228358
22protein localization to synapse (GO:0035418)3.90805493
23regulation of T-helper 1 cell differentiation (GO:0045625)3.89885690
24regulation of cytokine secretion involved in immune response (GO:0002739)3.86426375
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.85380021
26regulation of pigment cell differentiation (GO:0050932)3.84493044
27ATP synthesis coupled proton transport (GO:0015986)3.82712062
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.82712062
29glutamate receptor signaling pathway (GO:0007215)3.81081675
30regulation of vitamin metabolic process (GO:0030656)3.79332977
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.78974558
32negative regulation of cell killing (GO:0031342)3.78974558
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74901999
34regulation of interferon-alpha production (GO:0032647)3.72669924
35positive regulation by symbiont of host defense response (GO:0052509)3.64823945
36modulation by symbiont of host defense response (GO:0052031)3.64823945
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64823945
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64823945
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.64823945
40modulation by symbiont of host immune response (GO:0052553)3.64823945
41type I interferon signaling pathway (GO:0060337)3.62102476
42cellular response to type I interferon (GO:0071357)3.62102476
43neuron remodeling (GO:0016322)3.58556124
44transmission of nerve impulse (GO:0019226)3.57305665
45response to type I interferon (GO:0034340)3.57276111
46regulation of interferon-beta biosynthetic process (GO:0045357)3.55289210
47regulation of mononuclear cell migration (GO:0071675)3.54711020
48positive regulation of antigen processing and presentation (GO:0002579)3.51567798
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.50802299
50positive regulation of chemokine biosynthetic process (GO:0045080)3.50670438
51interferon-gamma-mediated signaling pathway (GO:0060333)3.48696344
52negative regulation of neurotransmitter transport (GO:0051589)3.47370416
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.46331436
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.46022138
55angiotensin maturation (GO:0002003)3.45172646
56T-helper 1 type immune response (GO:0042088)3.43493159
57dendritic spine morphogenesis (GO:0060997)3.43219799
58positive regulation of dendritic spine development (GO:0060999)3.43079787
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41600433
60glycosphingolipid catabolic process (GO:0046479)3.39284847
61microglial cell activation (GO:0001774)3.38973935
62response to histamine (GO:0034776)3.37982541
63positive regulation of heat generation (GO:0031652)3.36955220
64cranial nerve morphogenesis (GO:0021602)3.36096764
65regulation of antigen processing and presentation (GO:0002577)3.35946722
66negative regulation of cytokine production involved in immune response (GO:0002719)3.35321945
67regulation of chronic inflammatory response (GO:0002676)3.34073421
68defense response to protozoan (GO:0042832)3.32701782
69cerebral cortex radially oriented cell migration (GO:0021799)3.26706479
70protein neddylation (GO:0045116)3.26204592
71neuronal ion channel clustering (GO:0045161)3.24754491
72limb bud formation (GO:0060174)3.23189382
73detection of other organism (GO:0098543)3.23187897
74negative regulation of neurotransmitter secretion (GO:0046929)3.22806104
75regulation of dendritic spine development (GO:0060998)3.21954340
76righting reflex (GO:0060013)3.21515579
77response to protozoan (GO:0001562)3.19764837
78granulocyte activation (GO:0036230)3.19271948
79negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.18887932
80positive regulation of interferon-alpha production (GO:0032727)3.18556109
81regulation of chemokine biosynthetic process (GO:0045073)3.17224055
82regulation of interleukin-12 production (GO:0032655)3.16773657
83macrophage activation (GO:0042116)3.15524986
84fat-soluble vitamin biosynthetic process (GO:0042362)3.14907940
85regulation of synapse assembly (GO:0051963)3.14608278
86regulation of fever generation (GO:0031620)3.13098557
87axonal fasciculation (GO:0007413)3.13079121
88positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.12373648
89positive regulation of type 2 immune response (GO:0002830)3.11967594
90glycolipid catabolic process (GO:0019377)3.09335770
91B cell mediated immunity (GO:0019724)3.09152868
92long-chain fatty acid biosynthetic process (GO:0042759)3.08576286
93NIK/NF-kappaB signaling (GO:0038061)3.08472036
94myeloid dendritic cell differentiation (GO:0043011)3.07787311
95synaptic transmission, glutamatergic (GO:0035249)3.07085294
96neuron-neuron synaptic transmission (GO:0007270)3.06850447
97regulation of glutamate receptor signaling pathway (GO:1900449)3.05338432
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05253726
99detection of bacterium (GO:0016045)3.04194509
100regulation of interleukin-8 biosynthetic process (GO:0045414)3.03939567
101phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.02228064
102negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.01737293
103hydrogen peroxide biosynthetic process (GO:0050665)2.99810901
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96437050
105negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95071023
106substrate-independent telencephalic tangential migration (GO:0021826)2.93956246
107substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.93956246
108GTP biosynthetic process (GO:0006183)2.93528589
109positive regulation of NF-kappaB import into nucleus (GO:0042346)2.93260503
110negative regulation of myeloid cell apoptotic process (GO:0033033)2.92497868
111regulation of dendritic spine morphogenesis (GO:0061001)2.91944373
112germinal center formation (GO:0002467)2.91660097
113oligosaccharide catabolic process (GO:0009313)2.90590340
114positive regulation of membrane potential (GO:0045838)2.90500993
115respiratory electron transport chain (GO:0022904)2.90261140
116regulation of gamma-delta T cell activation (GO:0046643)2.89926129
117regulation of cholesterol esterification (GO:0010872)2.89635325
118ensheathment of neurons (GO:0007272)2.88780907
119axon ensheathment (GO:0008366)2.88780907
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88177913
121regulation of T cell tolerance induction (GO:0002664)2.87998621
122myeloid cell activation involved in immune response (GO:0002275)2.87856850
123positive regulation of dendritic spine morphogenesis (GO:0061003)2.87844493
124membrane hyperpolarization (GO:0060081)2.87488887
125neutrophil activation (GO:0042119)2.87270378
126synaptic vesicle exocytosis (GO:0016079)2.86836406
127myelination (GO:0042552)2.86479411
128regulation of inflammatory response to antigenic stimulus (GO:0002861)2.84901442
129negative regulation of interleukin-1 beta production (GO:0032691)2.84711960
130monocyte chemotaxis (GO:0002548)2.84129833
131branching involved in labyrinthine layer morphogenesis (GO:0060670)2.83910795
132ceramide catabolic process (GO:0046514)2.83585064
133nucleobase catabolic process (GO:0046113)2.82302909
134mating behavior (GO:0007617)2.81356460
135cellular response to interferon-gamma (GO:0071346)2.80242918
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79771506
137sialylation (GO:0097503)2.79666787
138electron transport chain (GO:0022900)2.79219570
139myeloid dendritic cell activation (GO:0001773)2.78887629
140oligodendrocyte differentiation (GO:0048709)2.78062671
141regulation of dopamine metabolic process (GO:0042053)2.77985344
142regulation of catecholamine metabolic process (GO:0042069)2.77985344
143antigen processing and presentation of endogenous antigen (GO:0019883)2.77704544
144eosinophil chemotaxis (GO:0048245)2.76958062
145regulation of excitatory postsynaptic membrane potential (GO:0060079)2.75979891
146long-term memory (GO:0007616)2.74861299
147virion attachment to host cell (GO:0019062)2.74780061
148adhesion of symbiont to host cell (GO:0044650)2.74780061
149adult walking behavior (GO:0007628)2.74557702
150negative regulation of nitric oxide biosynthetic process (GO:0045019)2.73333885
151forebrain neuron development (GO:0021884)2.72503762
152antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72273996
153regulation of heat generation (GO:0031650)2.71829728
154positive regulation of interferon-beta production (GO:0032728)2.71041226
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70342874
156positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70005751
157response to interferon-gamma (GO:0034341)2.69998582
158negative regulation of production of molecular mediator of immune response (GO:0002701)2.69573144
159detection of external biotic stimulus (GO:0098581)2.68838339
160negative regulation of growth of symbiont in host (GO:0044130)2.68788194
161negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.68788194
162modulation of growth of symbiont involved in interaction with host (GO:0044144)2.68788194
163regulation of growth of symbiont in host (GO:0044126)2.68788194
164positive regulation of interleukin-1 beta secretion (GO:0050718)2.67852565
165startle response (GO:0001964)2.67617818
166detection of molecule of bacterial origin (GO:0032490)2.65853340
167reactive oxygen species biosynthetic process (GO:1903409)2.65371320
168positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.64984847
169positive regulation of toll-like receptor signaling pathway (GO:0034123)2.64800924
170regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63799762
171positive regulation of interleukin-12 production (GO:0032735)2.63078804
172respiratory burst (GO:0045730)2.62908762
173retina layer formation (GO:0010842)2.62456821
174positive regulation of action potential (GO:0045760)2.61914232
175antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61337082
176regulation of postsynaptic membrane potential (GO:0060078)2.60490022
177central nervous system projection neuron axonogenesis (GO:0021952)2.58948194
178synaptic transmission, dopaminergic (GO:0001963)2.58838738
179nonmotile primary cilium assembly (GO:0035058)2.57719369
180regulation of glutamate secretion (GO:0014048)2.57173350
181developmental pigmentation (GO:0048066)2.56245994
182synapse assembly (GO:0007416)2.54736312
183regulation of vesicle fusion (GO:0031338)2.54445721
184regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.54009328
185negative regulation of execution phase of apoptosis (GO:1900118)2.53113795
186spinal cord development (GO:0021510)2.51584411
187dendrite development (GO:0016358)2.51107406
188lymphoid progenitor cell differentiation (GO:0002320)2.51042245
189layer formation in cerebral cortex (GO:0021819)2.49600654
190cellular response to epinephrine stimulus (GO:0071872)2.48944908
191adult feeding behavior (GO:0008343)2.48257600
192substantia nigra development (GO:0021762)2.47896371
193positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.46384437
194regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46353279
195regulation of synapse organization (GO:0050807)2.46010561
196DNA damage response, detection of DNA damage (GO:0042769)2.44719575
197behavioral defense response (GO:0002209)2.43587081
198behavioral fear response (GO:0001662)2.43587081
199L-fucose metabolic process (GO:0042354)2.43033857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.03374555
2EZH2_22144423_ChIP-Seq_EOC_Human6.75516839
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.44214823
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.55233378
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.83107049
6GBX2_23144817_ChIP-Seq_PC3_Human3.68400920
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.52972513
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.24045847
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22311239
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.21910936
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.08459074
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06412207
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95991610
14TAF15_26573619_Chip-Seq_HEK293_Human2.89682645
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89458259
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.87897939
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72007933
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67921360
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67921360
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.65647143
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62817700
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60092507
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60064161
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.56889420
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53268077
26* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50495086
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.38854610
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38741334
29CBX2_27304074_Chip-Seq_ESCs_Mouse2.38617328
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31497361
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31243482
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29522438
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25180030
34VDR_24787735_ChIP-Seq_THP-1_Human2.21340772
35CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19028819
36VDR_22108803_ChIP-Seq_LS180_Human2.16193359
37MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15957915
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13162680
39RNF2_27304074_Chip-Seq_ESCs_Mouse2.10450149
40CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09128143
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06424767
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04870424
43CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01158783
44AR_21572438_ChIP-Seq_LNCaP_Human1.99546803
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.97778682
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97575315
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97248415
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92576215
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92408025
50REST_21632747_ChIP-Seq_MESCs_Mouse1.91777970
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88246802
52* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85426072
53RUNX_20019798_ChIP-Seq_JUKART_Human1.85021613
54VDR_24763502_ChIP-Seq_THP-1_Human1.84429393
55SPI1_23127762_ChIP-Seq_K562_Human1.84177217
56SPI1_23547873_ChIP-Seq_NB4_Human1.82960144
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82947122
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.74050752
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72531880
60FUS_26573619_Chip-Seq_HEK293_Human1.72495025
61P300_19829295_ChIP-Seq_ESCs_Human1.67727425
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67250794
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67072493
64DROSHA_22980978_ChIP-Seq_HELA_Human1.65661079
65IGF1R_20145208_ChIP-Seq_DFB_Human1.65182624
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.64076401
67RNF2_27304074_Chip-Seq_NSC_Mouse1.59683019
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58318896
69GATA1_22025678_ChIP-Seq_K562_Human1.57984362
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.57214570
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55873385
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55165750
73ER_23166858_ChIP-Seq_MCF-7_Human1.54960212
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54471034
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53970434
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52643710
77SCL_19346495_ChIP-Seq_HPC-7_Human1.51106993
78* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48529847
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45201989
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.44766207
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44705272
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44168038
83ZNF274_21170338_ChIP-Seq_K562_Hela1.43850121
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42493296
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41381767
86VDR_21846776_ChIP-Seq_THP-1_Human1.38192193
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.37628838
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37528967
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37432837
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36502334
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.33946060
92MYB_26560356_Chip-Seq_TH2_Human1.33665178
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.33037912
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31124573
95GATA3_26560356_Chip-Seq_TH2_Human1.30093148
96* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28075833
97SMAD4_21799915_ChIP-Seq_A2780_Human1.27931913
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.27770161
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27688751
100STAT1_20625510_ChIP-Seq_HELA_Human1.27065736
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.26886636
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.26083548
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23979561
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23413067
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22762537
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22364898
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.21806083
108BCL6_27268052_Chip-Seq_Bcells_Human1.20632534
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20431930
110* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19668305
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19316679
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.17520118
113* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17285032
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.14176445
115GATA3_27048872_Chip-Seq_THYMUS_Human1.13973448
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13752840
117PU_27001747_Chip-Seq_BMDM_Mouse1.12336652
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11397314
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11289849
120GATA1_19941827_ChIP-Seq_MEL_Mouse1.10934320
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.09499677
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09281088
123MAF_26560356_Chip-Seq_TH1_Human1.09023715
124P53_22387025_ChIP-Seq_ESCs_Mouse1.08073292
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07931789
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.07640626
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07471657
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04083925
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03532469
130P300_18555785_Chip-Seq_ESCs_Mouse1.03479056
131BP1_19119308_ChIP-ChIP_Hs578T_Human1.03178917
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02553866
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02553866
134RUNX2_22187159_ChIP-Seq_PCA_Human1.01472686
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01206109
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00988664
137PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00390033
138BCOR_27268052_Chip-Seq_Bcells_Human0.99966410
139WT1_19549856_ChIP-ChIP_CCG9911_Human0.99006769
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98623348
141CMYC_18555785_Chip-Seq_ESCs_Mouse0.98471958
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.98262671
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97011251
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.96132546
145PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95967633
146PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95749883
147JUN_21703547_ChIP-Seq_K562_Human0.95629180
148KDM2B_26808549_Chip-Seq_REH_Human0.95191440
149AR_25329375_ChIP-Seq_VCAP_Human0.94629968
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94413574
151MYB_26560356_Chip-Seq_TH1_Human0.93846301
152EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93352793
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93220846
154TAL1_26923725_Chip-Seq_HPCs_Mouse0.92923776
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92558322
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91889334
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91821083
158LXR_22158963_ChIP-Seq_LIVER_Mouse0.91426876
159MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91197707
160STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90641251
161RXR_22158963_ChIP-Seq_LIVER_Mouse0.89844943
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89105629
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88985733
164GATA1_19941826_ChIP-Seq_K562_Human0.88833902
165UTX_26944678_Chip-Seq_JUKART_Human0.88405715
166TCF4_23295773_ChIP-Seq_U87_Human0.88025527
167EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87750156
168SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87568250
169NOTCH1_21737748_ChIP-Seq_TLL_Human0.87275141
170SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87082056
171FLI1_27457419_Chip-Seq_LIVER_Mouse0.86614365
172LXR_22292898_ChIP-Seq_THP-1_Human0.86185679
173RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85282569
174P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84807919
175BCAT_22108803_ChIP-Seq_LS180_Human0.84750701
176NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82991292
177SMRT_27268052_Chip-Seq_Bcells_Human0.80882443
178CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79308321
179GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78480761
180BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78208503
181MAF_26560356_Chip-Seq_TH2_Human0.77921047
182SA1_27219007_Chip-Seq_Bcells_Human0.75749817
183PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75020186
184KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73694795
185PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73344041
186GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72005442
187TAF2_19829295_ChIP-Seq_ESCs_Human0.69580673
188PU.1_20513432_ChIP-Seq_Bcells_Mouse0.68534470
189GATA2_19941826_ChIP-Seq_K562_Human0.67730589
190SOX2_20726797_ChIP-Seq_SW620_Human0.67554475
191P300_27268052_Chip-Seq_Bcells_Human0.67076061
192SPI1_20517297_ChIP-Seq_HL60_Human0.66638280
193* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.65777063
194EGR1_19032775_ChIP-ChIP_M12_Human0.64995561
195CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.63228170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.40103283
2MP0006082_CNS_inflammation3.73502192
3MP0003436_decreased_susceptibility_to3.47179606
4MP0009785_altered_susceptibility_to3.38796082
5MP0002148_abnormal_hypersensitivity_rea3.37362203
6MP0001835_abnormal_antigen_presentation3.27306440
7MP0005671_abnormal_response_to3.05306472
8MP0005058_abnormal_lysosome_morphology3.03296929
9MP0001790_abnormal_immune_system2.96052891
10MP0005387_immune_system_phenotype2.96052891
11MP0004859_abnormal_synaptic_plasticity2.90936661
12MP0002139_abnormal_hepatobiliary_system2.89377329
13MP0002102_abnormal_ear_morphology2.87990675
14MP0009840_abnormal_foam_cell2.73576409
15MP0002419_abnormal_innate_immunity2.70071871
16MP0004742_abnormal_vestibular_system2.68693469
17MP0001486_abnormal_startle_reflex2.65962862
18MP0003635_abnormal_synaptic_transmissio2.65569392
19MP0005000_abnormal_immune_tolerance2.64817351
20MP0005025_abnormal_response_to2.61606905
21MP0009379_abnormal_foot_pigmentation2.60995787
22MP0006276_abnormal_autonomic_nervous2.59167848
23MP0005409_darkened_coat_color2.58903984
24MP0004270_analgesia2.58320328
25MP0001188_hyperpigmentation2.57901864
26MP0001968_abnormal_touch/_nociception2.55956144
27MP0002064_seizures2.49595415
28MP0009745_abnormal_behavioral_response2.43265465
29MP0002572_abnormal_emotion/affect_behav2.41056914
30MP0002272_abnormal_nervous_system2.37602764
31MP0001440_abnormal_grooming_behavior2.32839485
32MP0003300_gastrointestinal_ulcer2.32490603
33MP0001800_abnormal_humoral_immune2.27443087
34MP0009764_decreased_sensitivity_to2.26603772
35MP0002723_abnormal_immune_serum2.24448063
36MP0002452_abnormal_antigen_presenting2.23828410
37MP0001529_abnormal_vocalization2.18324224
38MP0002063_abnormal_learning/memory/cond2.17928048
39MP0003172_abnormal_lysosome_physiology2.17653708
40MP0002736_abnormal_nociception_after2.16027347
41MP0001485_abnormal_pinna_reflex2.12860356
42MP0001533_abnormal_skeleton_physiology2.10746021
43MP0000778_abnormal_nervous_system2.10204708
44MP0000685_abnormal_immune_system2.10006491
45MP0009046_muscle_twitch2.08349055
46MP0002067_abnormal_sensory_capabilities2.07967626
47MP0010155_abnormal_intestine_physiology2.06114318
48MP0002735_abnormal_chemical_nociception2.04101903
49MP0002734_abnormal_mechanical_nocicepti1.99210205
50MP0001905_abnormal_dopamine_level1.96639312
51MP0002733_abnormal_thermal_nociception1.95962646
52MP0004510_myositis1.92919788
53MP0004142_abnormal_muscle_tone1.91666367
54MP0005377_hearing/vestibular/ear_phenot1.89131344
55MP0003878_abnormal_ear_physiology1.89131344
56MP0001845_abnormal_inflammatory_respons1.88094616
57MP0001819_abnormal_immune_cell1.87122757
58MP0002420_abnormal_adaptive_immunity1.86069530
59MP0003806_abnormal_nucleotide_metabolis1.84230670
60MP0005423_abnormal_somatic_nervous1.84212982
61MP0000343_altered_response_to1.83192954
62MP0002822_catalepsy1.82979068
63MP0003195_calcinosis1.81689015
64MP0003136_yellow_coat_color1.80822175
65MP0000920_abnormal_myelination1.79272386
66MP0005167_abnormal_blood-brain_barrier1.77366817
67MP0008469_abnormal_protein_level1.77265082
68MP0003075_altered_response_to1.76442375
69MP0000462_abnormal_digestive_system1.76163716
70MP0001970_abnormal_pain_threshold1.73674233
71MP0002557_abnormal_social/conspecific_i1.70190857
72MP0003879_abnormal_hair_cell1.67101434
73MP0000604_amyloidosis1.60996639
74MP0005257_abnormal_intraocular_pressure1.58723435
75MP0001963_abnormal_hearing_physiology1.55795017
76MP0005174_abnormal_tail_pigmentation1.54400004
77MP0005381_digestive/alimentary_phenotyp1.52780090
78MP0002138_abnormal_hepatobiliary_system1.52746965
79MP0002405_respiratory_system_inflammati1.52516742
80MP0004947_skin_inflammation1.50367478
81MP0001664_abnormal_digestion1.49795671
82MP0001663_abnormal_digestive_system1.49159030
83MP0009278_abnormal_bone_marrow1.48466493
84MP0001501_abnormal_sleep_pattern1.47426982
85MP0005365_abnormal_bile_salt1.46541674
86MP0001853_heart_inflammation1.44739584
87MP0005551_abnormal_eye_electrophysiolog1.43750416
88MP0003938_abnormal_ear_development1.38432620
89MP0008004_abnormal_stomach_pH1.36368070
90MP0000026_abnormal_inner_ear1.35870767
91MP0002184_abnormal_innervation1.35545810
92MP0009333_abnormal_splenocyte_physiolog1.32433208
93MP0005451_abnormal_body_composition1.31356932
94MP0002254_reproductive_system_inflammat1.29610514
95MP0005166_decreased_susceptibility_to1.29401626
96MP0000013_abnormal_adipose_tissue1.28913094
97MP0002998_abnormal_bone_remodeling1.27918050
98MP0002882_abnormal_neuron_morphology1.27911005
99MP0003183_abnormal_peptide_metabolism1.26340376
100MP0003191_abnormal_cellular_cholesterol1.26297088
101MP0003315_abnormal_perineum_morphology1.25898362
102MP0000716_abnormal_immune_system1.25666465
103MP0002229_neurodegeneration1.24651688
104MP0003866_abnormal_defecation1.21517348
105MP0002066_abnormal_motor_capabilities/c1.20787154
106MP0005386_behavior/neurological_phenoty1.19991615
107MP0004924_abnormal_behavior1.19991615
108MP0005397_hematopoietic_system_phenotyp1.16545559
109MP0001545_abnormal_hematopoietic_system1.16545559
110MP0002938_white_spotting1.15945875
111MP0006054_spinal_hemorrhage1.13406277
112MP0005464_abnormal_platelet_physiology1.09865122
113MP0000955_abnormal_spinal_cord1.08248438
114MP0005379_endocrine/exocrine_gland_phen1.07824073
115MP0003303_peritoneal_inflammation1.06003932
116MP0002752_abnormal_somatic_nervous1.04602051
117MP0000015_abnormal_ear_pigmentation1.03015459
118MP0000631_abnormal_neuroendocrine_gland1.02907038
119MP0006292_abnormal_olfactory_placode1.01871271
120MP0003448_altered_tumor_morphology1.00625779
121MP0004019_abnormal_vitamin_homeostasis0.98611227
122MP0000751_myopathy0.96561689
123MP0002751_abnormal_autonomic_nervous0.94857029
124MP0003385_abnormal_body_wall0.94804689
125MP0000566_synostosis0.93968430
126MP0000689_abnormal_spleen_morphology0.90705084
127MP0002152_abnormal_brain_morphology0.90561253
128MP0002638_abnormal_pupillary_reflex0.90282574
129MP0002398_abnormal_bone_marrow0.90051224
130MP0004885_abnormal_endolymph0.89005227
131MP0008569_lethality_at_weaning0.88669960
132MP0005360_urolithiasis0.88622566
133MP0002429_abnormal_blood_cell0.87633073
134MP0002876_abnormal_thyroid_physiology0.87107441
135MP0003453_abnormal_keratinocyte_physiol0.87093836
136MP0006072_abnormal_retinal_apoptosis0.86255833
137MP0009763_increased_sensitivity_to0.86039091
138MP0003724_increased_susceptibility_to0.84585675
139MP0000858_altered_metastatic_potential0.82608857
140MP0005645_abnormal_hypothalamus_physiol0.82033109
141MP0005319_abnormal_enzyme/_coenzyme0.81789602
142MP0002653_abnormal_ependyma_morphology0.81697907
143MP0005085_abnormal_gallbladder_physiolo0.81340121
144MP0004883_abnormal_blood_vessel0.81063441
145MP0003634_abnormal_glial_cell0.80835754
146MP0000538_abnormal_urinary_bladder0.80601793
147MP0001666_abnormal_nutrient_absorption0.78930603
148MP0005390_skeleton_phenotype0.78738967
149MP0005164_abnormal_response_to0.78218973
150MP0001764_abnormal_homeostasis0.77352627
151MP0005171_absent_coat_pigmentation0.77185536
152MP0002722_abnormal_immune_system0.76731839
153MP0001986_abnormal_taste_sensitivity0.76507331
154MP0008875_abnormal_xenobiotic_pharmacok0.76407991
155MP0002277_abnormal_respiratory_mucosa0.76076767
156MP0004381_abnormal_hair_follicle0.74909498
157MP0000467_abnormal_esophagus_morphology0.74529785
158MP0004145_abnormal_muscle_electrophysio0.74314799
159MP0009250_abnormal_appendicular_skeleto0.74239493
160MP0010386_abnormal_urinary_bladder0.73140645
161MP0003646_muscle_fatigue0.73082058
162MP0008874_decreased_physiological_sensi0.72956350
163MP0003329_amyloid_beta_deposits0.72954743
164MP0002069_abnormal_eating/drinking_beha0.72693310
165MP0005195_abnormal_posterior_eye0.71198747
166MP0002933_joint_inflammation0.70865027
167MP0002332_abnormal_exercise_endurance0.69904271
168MP0004147_increased_porphyrin_level0.69829868
169MP0005535_abnormal_body_temperature0.69553355
170MP0001873_stomach_inflammation0.68237442
171MP0003690_abnormal_glial_cell0.67985764
172MP0009765_abnormal_xenobiotic_induced0.66418841
173MP0005084_abnormal_gallbladder_morpholo0.65769298
174MP0003828_pulmonary_edema0.65305794
175MP0004811_abnormal_neuron_physiology0.63910025
176MP0005310_abnormal_salivary_gland0.63350067
177MP0000249_abnormal_blood_vessel0.63059974
178MP0000049_abnormal_middle_ear0.62453177
179MP0002693_abnormal_pancreas_physiology0.61294766
180MP0005647_abnormal_sex_gland0.60766468
181MP0000609_abnormal_liver_physiology0.60438705
182MP0009643_abnormal_urine_homeostasis0.60328441
183MP0002837_dystrophic_cardiac_calcinosis0.58420597
184MP0003656_abnormal_erythrocyte_physiolo0.56859208
185MP0002118_abnormal_lipid_homeostasis0.55393388
186MP0001851_eye_inflammation0.54314869

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.01909108
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.01909108
3Abnormality of glycolipid metabolism (HP:0010969)6.01909108
4Optic neuritis (HP:0100653)5.02197466
5Retrobulbar optic neuritis (HP:0100654)5.02197466
6Orchitis (HP:0100796)5.00062996
7Abnormality of macrophages (HP:0004311)4.85855079
8Vacuolated lymphocytes (HP:0001922)4.81841200
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.79692868
10Myositis (HP:0100614)4.68652658
11Systemic lupus erythematosus (HP:0002725)4.60534829
12Recurrent bacterial skin infections (HP:0005406)4.44989125
13Stomatitis (HP:0010280)4.43920826
14Focal motor seizures (HP:0011153)4.39445674
15Eczematoid dermatitis (HP:0000976)4.37437112
16Increased cerebral lipofuscin (HP:0011813)4.37341500
17Recurrent abscess formation (HP:0002722)4.30975111
18Dysostosis multiplex (HP:0000943)3.90715772
19Mutism (HP:0002300)3.83013516
20Hyperthyroidism (HP:0000836)3.81297851
21Degeneration of the lateral corticospinal tracts (HP:0002314)3.72843775
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.72843775
23Disinhibition (HP:0000734)3.70581205
24Renal Fanconi syndrome (HP:0001994)3.68460270
25Recurrent gram-negative bacterial infections (HP:0005420)3.67757167
26Mediastinal lymphadenopathy (HP:0100721)3.65836774
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.65594390
28Loss of speech (HP:0002371)3.64217670
29Autoimmune thrombocytopenia (HP:0001973)3.56436116
30Keratoconjunctivitis sicca (HP:0001097)3.38285001
31Atonic seizures (HP:0010819)3.35421168
32Absent/shortened dynein arms (HP:0200106)3.34774496
33Dynein arm defect of respiratory motile cilia (HP:0012255)3.34774496
34Keratoconjunctivitis (HP:0001096)3.27289538
35Elevated erythrocyte sedimentation rate (HP:0003565)3.24606979
36Bowel incontinence (HP:0002607)3.20570973
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.19828826
38Abnormality of polysaccharide metabolism (HP:0011012)3.19828826
39Abnormality of glycosaminoglycan metabolism (HP:0004371)3.19828826
40Abnormal large intestine physiology (HP:0012700)3.18137184
41Malnutrition (HP:0004395)3.06025924
42Glomerulonephritis (HP:0000099)3.02168705
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02059177
44Epileptic encephalopathy (HP:0200134)3.01664590
45Increased hepatocellular lipid droplets (HP:0006565)3.01254772
46Sensory axonal neuropathy (HP:0003390)2.98120456
47Congenital ichthyosiform erythroderma (HP:0007431)2.96907223
48Hematochezia (HP:0002573)2.95132887
49Obstructive lung disease (HP:0006536)2.95030775
50Chronic obstructive pulmonary disease (HP:0006510)2.95030775
51Fragile nails (HP:0001808)2.93072208
52Seborrheic dermatitis (HP:0001051)2.92442930
53Abnormal ciliary motility (HP:0012262)2.91976451
54Encephalitis (HP:0002383)2.91789533
55Urinary glycosaminoglycan excretion (HP:0003541)2.90925210
56Mucopolysacchariduria (HP:0008155)2.90925210
57Pulmonary infiltrates (HP:0002113)2.90910564
58Broad-based gait (HP:0002136)2.90858515
59Febrile seizures (HP:0002373)2.90736158
60Vasculitis (HP:0002633)2.89968957
61Neurofibrillary tangles (HP:0002185)2.88099629
62Concave nail (HP:0001598)2.87760674
63Hyperventilation (HP:0002883)2.85537005
64Hemoptysis (HP:0002105)2.85330744
65Recurrent fungal infections (HP:0002841)2.84801705
66Abnormality of the corticospinal tract (HP:0002492)2.79753497
67Focal seizures (HP:0007359)2.73753141
68Parakeratosis (HP:0001036)2.71094818
69Esotropia (HP:0000565)2.67251930
70Mitochondrial inheritance (HP:0001427)2.66797714
71Recurrent skin infections (HP:0001581)2.64829768
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63882883
73Thickened helices (HP:0000391)2.62479953
74Abnormal respiratory epithelium morphology (HP:0012253)2.58930690
75Abnormal respiratory motile cilium morphology (HP:0005938)2.58930690
76Metaphyseal irregularity (HP:0003025)2.58257206
77Amyloidosis (HP:0011034)2.58022683
78Acute necrotizing encephalopathy (HP:0006965)2.55224532
79Amblyopia (HP:0000646)2.54701206
80Atelectasis (HP:0100750)2.54697163
81Progressive macrocephaly (HP:0004481)2.54537376
82Gastrointestinal infarctions (HP:0005244)2.52690627
83Increased IgM level (HP:0003496)2.50448128
84Meningitis (HP:0001287)2.48095700
85Gangrene (HP:0100758)2.47515829
86Cerebral inclusion bodies (HP:0100314)2.47429466
87Entropion (HP:0000621)2.42957091
88Polyphagia (HP:0002591)2.42082773
89Abnormality of renal resorption (HP:0011038)2.40927862
90Overfolded helix (HP:0000396)2.40656111
91Abnormality of DNA repair (HP:0003254)2.39841755
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.39376406
93Absence seizures (HP:0002121)2.38776908
94Cone-rod dystrophy (HP:0000548)2.38651694
95Limb dystonia (HP:0002451)2.37868095
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37573150
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37276258
98Increased serum ferritin (HP:0003281)2.36719080
99Dialeptic seizures (HP:0011146)2.36587174
100Optic disc pallor (HP:0000543)2.35452148
101Hypertensive crisis (HP:0100735)2.34534277
102Nausea (HP:0002018)2.33924481
103Lipid accumulation in hepatocytes (HP:0006561)2.33894696
104Anorexia (HP:0002039)2.29528515
105Abnormal respiratory motile cilium physiology (HP:0012261)2.28546720
106Absent speech (HP:0001344)2.26932000
107Petechiae (HP:0000967)2.25381701
108Polyneuropathy (HP:0001271)2.25250690
109Abnormally folded helix (HP:0008544)2.24479247
110Truncus arteriosus (HP:0001660)2.24137300
111Gingivitis (HP:0000230)2.22596277
112Failure to thrive in infancy (HP:0001531)2.17547916
113Purpura (HP:0000979)2.15986945
114Poikiloderma (HP:0001029)2.15597650
115Erythroderma (HP:0001019)2.13026399
116Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12791365
117Abnormality of the pleura (HP:0002103)2.11620340
118Joint swelling (HP:0001386)2.10152368
119Hepatocellular necrosis (HP:0001404)2.09854891
120Visual hallucinations (HP:0002367)2.09369019
121Abnormality of iron homeostasis (HP:0011031)2.09021187
122Inappropriate behavior (HP:0000719)2.07342273
123Progressive neurologic deterioration (HP:0002344)2.06996589
124Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06475545
125Flat occiput (HP:0005469)2.06219687
126Chronic mucocutaneous candidiasis (HP:0002728)2.04995414
127Recurrent cutaneous fungal infections (HP:0011370)2.04995414
128Abnormality of the parathyroid morphology (HP:0011766)2.04986469
129Urticaria (HP:0001025)2.04293141
130Abnormal delayed hypersensitivity skin test (HP:0002963)2.02034715
131Abnormality of the tricuspid valve (HP:0001702)2.01700908
132Nuclear cataract (HP:0100018)2.01484216
133Retinal dysplasia (HP:0007973)2.00945157
134Axonal loss (HP:0003447)2.00757734
135Arterial thrombosis (HP:0004420)1.99930134
136Deep palmar crease (HP:0006191)1.99666270
137Episodic fever (HP:0001954)1.99509990
138Pulmonary embolism (HP:0002204)1.99419155
139Akinesia (HP:0002304)1.98737133
140Abnormality of transition element cation homeostasis (HP:0011030)1.98168037
141Exotropia (HP:0000577)1.98138045
142Hypoparathyroidism (HP:0000829)1.96692579
143Leukocytosis (HP:0001974)1.96547772
144Recurrent viral infections (HP:0004429)1.96542037
145Agnosia (HP:0010524)1.96127702
146Chronic diarrhea (HP:0002028)1.94935474
147Abnormality of T cell number (HP:0011839)1.93926638
148Abnormal mitochondria in muscle tissue (HP:0008316)1.93140417
149Hepatosplenomegaly (HP:0001433)1.93035050
150Insidious onset (HP:0003587)1.92620892
151Termporal pattern (HP:0011008)1.92620892
152Hypophosphatemic rickets (HP:0004912)1.92569933
153Abnormality of the axillary hair (HP:0100134)1.90662667
154Abnormality of secondary sexual hair (HP:0009888)1.90662667
155Complement deficiency (HP:0004431)1.90631039
156Asthma (HP:0002099)1.90414176
157Acute encephalopathy (HP:0006846)1.90279133
158Neuronal loss in central nervous system (HP:0002529)1.90128534
159Widely patent fontanelles and sutures (HP:0004492)1.89870007
160Spontaneous hematomas (HP:0007420)1.89686083
161Recurrent pneumonia (HP:0006532)1.89384453
162Acne (HP:0001061)1.88297465
163Vertigo (HP:0002321)1.88030835
164Clumsiness (HP:0002312)1.87827440
165T lymphocytopenia (HP:0005403)1.87372730
166Hyperphosphaturia (HP:0003109)1.86965889
167Congenital malformation of the right heart (HP:0011723)1.86896899
168Double outlet right ventricle (HP:0001719)1.86896899
169Abnormality of the vasculature of the conjunctiva (HP:0008054)1.86174186
170Partial agenesis of the corpus callosum (HP:0001338)1.85847953
171Memory impairment (HP:0002354)1.85649612
172Glycosuria (HP:0003076)1.84024853
173Abnormality of urine glucose concentration (HP:0011016)1.84024853
174Pustule (HP:0200039)1.83909086
175Abnormal eating behavior (HP:0100738)1.83634170
176Exertional dyspnea (HP:0002875)1.83599731
177Alacrima (HP:0000522)1.83570410
178Progressive cerebellar ataxia (HP:0002073)1.83516286
179Increased CSF lactate (HP:0002490)1.82957579
180Hypergammaglobulinemia (HP:0010702)1.82144428
181Abnormality of lateral ventricle (HP:0030047)1.81583051
182Basal ganglia calcification (HP:0002135)1.81554761
183Dysmetria (HP:0001310)1.81050336
184Supranuclear gaze palsy (HP:0000605)1.80293033
185Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79987481
186Abnormality of the septum pellucidum (HP:0007375)1.79087471
187Anomalous pulmonary venous return (HP:0010772)1.78564736
188Increased intramyocellular lipid droplets (HP:0012240)1.78377325
189Keratitis (HP:0000491)1.78362022
190Diminished motivation (HP:0000745)1.78049522
191Nasolacrimal duct obstruction (HP:0000579)1.77945881
192Decreased lacrimation (HP:0000633)1.77485561
193Protruding tongue (HP:0010808)1.76668808
194Abnormality of the pericardium (HP:0001697)1.75982270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.64153047
2TLK14.64131242
3TNIK3.89732155
4ACVR1B3.31827826
5MAPK153.17511222
6IRAK33.13662173
7BLK3.10331751
8TYK22.80020272
9MAP4K12.74401906
10FES2.70818523
11MAP3K112.66143701
12MKNK22.52867951
13ADRBK22.48884039
14NME12.48216790
15MST1R2.46327780
16TBK12.44364803
17RIPK42.42216065
18MATK2.39145542
19TXK2.36281522
20MAP3K142.32826486
21ERN12.30023573
22CDK192.27494656
23NTRK32.10120847
24PNCK2.09041235
25IKBKE2.08969392
26IKBKB2.04950835
27IRAK22.01505488
28MAP3K122.00558085
29EPHA41.98686932
30TAOK21.98120935
31STK161.98069737
32OXSR11.90938447
33TGFBR21.89835452
34STK391.82705632
35DDR21.74674912
36TAOK11.71910522
37PIK3CA1.63675432
38MARK11.60115004
39MAPK131.52411810
40SYK1.51870169
41JAK31.49361566
42FGR1.48863628
43PRPF4B1.47467256
44CSF1R1.43667774
45MAP3K31.40706364
46UHMK11.38921350
47MST41.32776558
48RIPK11.31374106
49KIT1.30226043
50MAP2K71.29653739
51MAP2K21.28115728
52ZAP701.27482567
53PKN11.26276966
54BMPR1B1.24530380
55CAMK2B1.23045575
56MAP2K31.22577418
57SIK21.20369277
58NME21.17510387
59CDC42BPA1.16054706
60BRAF1.15462168
61JAK11.10313010
62MKNK11.08348381
63LCK1.06684135
64YES11.03891921
65MAP2K61.03730371
66TAOK31.01746993
67JAK21.00287216
68KSR21.00194511
69BTK1.00124653
70PIM20.99040648
71MOS0.98929035
72MAP3K10.97038793
73CDK50.92949974
74NTRK20.92797508
75CAMK2D0.91479212
76DAPK20.90814645
77ROCK20.90482626
78ABL20.88733707
79CAMKK20.86440480
80CHUK0.86134060
81CAMK2A0.84969780
82MAP3K90.83383434
83GRK60.82316172
84HCK0.80605754
85LIMK10.80470098
86FRK0.80221429
87MINK10.79574798
88MAP3K40.78013810
89PAK60.76121225
90IRAK10.75818774
91EPHB10.74959330
92STK110.74861755
93MARK30.74715304
94DYRK1A0.72697778
95TNK20.72376399
96BMPR20.72020421
97MET0.70682738
98CAMK1G0.69311363
99MAP3K50.69306939
100AKT30.65452450
101RAF10.63839534
102TGFBR10.62657957
103GRK10.60328159
104PDK10.58807561
105IRAK40.58793635
106CDK80.57933600
107DMPK0.57920413
108TEC0.54847623
109FYN0.54844576
110CLK10.53718569
111DYRK20.53589815
112PRKG20.53410188
113GRK50.53274874
114MAP2K40.53065368
115CDK140.52444510
116CSNK1G30.50786913
117WNK40.50035148
118EPHA30.49795230
119PIM10.49541512
120MAP3K20.49092575
121PTK2B0.48695079
122ITK0.48257016
123NEK60.47290154
124ABL10.47146107
125PLK20.46680980
126PDPK10.46285494
127CSK0.45841934
128DAPK30.44216590
129MAP3K60.43728302
130CSNK1G20.43191061
131PRKCE0.43177152
132CDK150.42647382
133PRKCQ0.42475734
134CDK11A0.41893383
135EPHB20.41208849
136PRKCG0.40755536
137CDK180.39938693
138NTRK10.39539267
139RPS6KA60.39418208
140CAMK2G0.37909449
141LYN0.37807464
142BCKDK0.37600717
143GRK70.37591251
144ADRBK10.37260787
145PRKCZ0.36578957
146RPS6KL10.35111492
147RPS6KC10.35111492
148SIK30.34656171
149PRKG10.34630011
150STK100.34610998
151TYRO30.34385308
152PRKD20.34298303
153TESK20.32403626
154KSR10.31687052
155CSNK1G10.31685405
156MARK20.31521738
157PRKCD0.31295907
158MAP3K130.30729194
159BCR0.29567070
160RPS6KA20.29504405
161GSK3A0.26799123
162PRKACG0.25106028
163CAMK1D0.24217091
164MAPK40.21915831
165INSR0.20767689
166FGFR30.20421277
167MAPKAPK20.20336551
168PRKAA20.20188038

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.54529852
2Oxidative phosphorylation_Homo sapiens_hsa001903.43906720
3Staphylococcus aureus infection_Homo sapiens_hsa051503.02120492
4Allograft rejection_Homo sapiens_hsa053302.99945799
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.85013787
6Leishmaniasis_Homo sapiens_hsa051402.73131622
7Graft-versus-host disease_Homo sapiens_hsa053322.70947774
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.66556597
9Alzheimers disease_Homo sapiens_hsa050102.57597824
10Osteoclast differentiation_Homo sapiens_hsa043802.57107106
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.54969178
12Autoimmune thyroid disease_Homo sapiens_hsa053202.43401798
13Parkinsons disease_Homo sapiens_hsa050122.41357422
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38100540
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28427390
16Lysosome_Homo sapiens_hsa041422.28040438
17Long-term depression_Homo sapiens_hsa047302.25222041
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.20534942
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.17173501
20NOD-like receptor signaling pathway_Homo sapiens_hsa046212.16679031
21Glutamatergic synapse_Homo sapiens_hsa047242.13485922
22Type I diabetes mellitus_Homo sapiens_hsa049402.13122881
23Serotonergic synapse_Homo sapiens_hsa047262.04062109
24Pertussis_Homo sapiens_hsa051332.02054419
25NF-kappa B signaling pathway_Homo sapiens_hsa040642.01405008
26Tuberculosis_Homo sapiens_hsa051521.97750818
27Mineral absorption_Homo sapiens_hsa049781.92624040
28Malaria_Homo sapiens_hsa051441.86262950
29Axon guidance_Homo sapiens_hsa043601.85161355
30Long-term potentiation_Homo sapiens_hsa047201.83824195
31TNF signaling pathway_Homo sapiens_hsa046681.81628567
32Morphine addiction_Homo sapiens_hsa050321.81520807
33Antigen processing and presentation_Homo sapiens_hsa046121.77941431
34Huntingtons disease_Homo sapiens_hsa050161.76820094
35Salivary secretion_Homo sapiens_hsa049701.75020758
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.74036754
37Phototransduction_Homo sapiens_hsa047441.72234323
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71791585
39Legionellosis_Homo sapiens_hsa051341.67912698
40Taste transduction_Homo sapiens_hsa047421.62888355
41Sphingolipid metabolism_Homo sapiens_hsa006001.61507321
42GABAergic synapse_Homo sapiens_hsa047271.58649839
43Cardiac muscle contraction_Homo sapiens_hsa042601.56667080
44Hematopoietic cell lineage_Homo sapiens_hsa046401.53457668
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50222504
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49508348
47Salmonella infection_Homo sapiens_hsa051321.49310499
48Circadian entrainment_Homo sapiens_hsa047131.48800090
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48535828
50Renin-angiotensin system_Homo sapiens_hsa046141.47440961
51Fat digestion and absorption_Homo sapiens_hsa049751.46843519
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44403401
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42785888
54Collecting duct acid secretion_Homo sapiens_hsa049661.42477435
55Amphetamine addiction_Homo sapiens_hsa050311.41783336
56Influenza A_Homo sapiens_hsa051641.39393423
57Dopaminergic synapse_Homo sapiens_hsa047281.38150638
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35350594
59Ether lipid metabolism_Homo sapiens_hsa005651.34833542
60Toxoplasmosis_Homo sapiens_hsa051451.34747967
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34078437
62Cholinergic synapse_Homo sapiens_hsa047251.30945709
63Synaptic vesicle cycle_Homo sapiens_hsa047211.30659012
64Primary immunodeficiency_Homo sapiens_hsa053401.30077974
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26732346
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25899688
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22835998
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22328338
69Renin secretion_Homo sapiens_hsa049241.21587153
70Gap junction_Homo sapiens_hsa045401.20913090
71Ribosome_Homo sapiens_hsa030101.19429717
72Cocaine addiction_Homo sapiens_hsa050301.14556840
73Chemokine signaling pathway_Homo sapiens_hsa040621.09106732
74Herpes simplex infection_Homo sapiens_hsa051681.09022358
75Viral myocarditis_Homo sapiens_hsa054161.08008231
76Gastric acid secretion_Homo sapiens_hsa049711.06715141
77Oxytocin signaling pathway_Homo sapiens_hsa049211.05092054
78Measles_Homo sapiens_hsa051621.01332783
79Calcium signaling pathway_Homo sapiens_hsa040201.00764145
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.99523574
81GnRH signaling pathway_Homo sapiens_hsa049120.94008570
82ErbB signaling pathway_Homo sapiens_hsa040120.89578794
83Vibrio cholerae infection_Homo sapiens_hsa051100.88237168
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.87998102
85Insulin secretion_Homo sapiens_hsa049110.86764166
86Tryptophan metabolism_Homo sapiens_hsa003800.86195267
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85760903
88Olfactory transduction_Homo sapiens_hsa047400.84991509
89Choline metabolism in cancer_Homo sapiens_hsa052310.84885887
90African trypanosomiasis_Homo sapiens_hsa051430.84141529
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81261485
92Hepatitis C_Homo sapiens_hsa051600.80489748
93Shigellosis_Homo sapiens_hsa051310.80031559
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77793029
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.77575262
96T cell receptor signaling pathway_Homo sapiens_hsa046600.76107346
97Sulfur metabolism_Homo sapiens_hsa009200.74074355
98Pancreatic secretion_Homo sapiens_hsa049720.73256722
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72667173
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.71706744
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70252420
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69614171
103Complement and coagulation cascades_Homo sapiens_hsa046100.69584095
104PPAR signaling pathway_Homo sapiens_hsa033200.66122356
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65254181
106Galactose metabolism_Homo sapiens_hsa000520.64101541
107VEGF signaling pathway_Homo sapiens_hsa043700.63590466
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63236259
109Protein export_Homo sapiens_hsa030600.61964699
110Vitamin digestion and absorption_Homo sapiens_hsa049770.61330461
111Arachidonic acid metabolism_Homo sapiens_hsa005900.60744270
112Melanogenesis_Homo sapiens_hsa049160.60317979
113Caffeine metabolism_Homo sapiens_hsa002320.60289779
114Hepatitis B_Homo sapiens_hsa051610.60118990
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60030460
116Prion diseases_Homo sapiens_hsa050200.59754227
117Fatty acid elongation_Homo sapiens_hsa000620.59485408
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59264830
119cAMP signaling pathway_Homo sapiens_hsa040240.59057446
120Other glycan degradation_Homo sapiens_hsa005110.58516963
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.57217187
122Histidine metabolism_Homo sapiens_hsa003400.56195181
123Glioma_Homo sapiens_hsa052140.55260506
124Ras signaling pathway_Homo sapiens_hsa040140.54158401
125Renal cell carcinoma_Homo sapiens_hsa052110.53915686
126Estrogen signaling pathway_Homo sapiens_hsa049150.53469206
127Apoptosis_Homo sapiens_hsa042100.52456325
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.51141600
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48835750
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46990853
131Steroid biosynthesis_Homo sapiens_hsa001000.46489593
132Phagosome_Homo sapiens_hsa041450.45666571
133Linoleic acid metabolism_Homo sapiens_hsa005910.45616161
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45221036
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43505870
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41907262
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.41058134
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40741472
139Thyroid hormone synthesis_Homo sapiens_hsa049180.40328039
140Melanoma_Homo sapiens_hsa052180.38886181
141Fanconi anemia pathway_Homo sapiens_hsa034600.38253358
142Alcoholism_Homo sapiens_hsa050340.38059549
143Sulfur relay system_Homo sapiens_hsa041220.37632041
144Rheumatoid arthritis_Homo sapiens_hsa053230.36539926
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35995002
146Amoebiasis_Homo sapiens_hsa051460.35893212
147Protein digestion and absorption_Homo sapiens_hsa049740.34933888
148Type II diabetes mellitus_Homo sapiens_hsa049300.34800894
149Asthma_Homo sapiens_hsa053100.34192916
150Fructose and mannose metabolism_Homo sapiens_hsa000510.34026895
151Epstein-Barr virus infection_Homo sapiens_hsa051690.33066175
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.32988363
153B cell receptor signaling pathway_Homo sapiens_hsa046620.32672010
154Prolactin signaling pathway_Homo sapiens_hsa049170.32245405
155MAPK signaling pathway_Homo sapiens_hsa040100.31842293
156Acute myeloid leukemia_Homo sapiens_hsa052210.30160890
157Homologous recombination_Homo sapiens_hsa034400.29588423
158Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28145318
159Starch and sucrose metabolism_Homo sapiens_hsa005000.27756456
160Bladder cancer_Homo sapiens_hsa052190.26108725
161Chemical carcinogenesis_Homo sapiens_hsa052040.26056960
162Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24454845
163Glycerolipid metabolism_Homo sapiens_hsa005610.23643591
164Dorso-ventral axis formation_Homo sapiens_hsa043200.21824721
165AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21629276
166ABC transporters_Homo sapiens_hsa020100.21546806
167Maturity onset diabetes of the young_Homo sapiens_hsa049500.21221468
168Leukocyte transendothelial migration_Homo sapiens_hsa046700.20323511
169Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17651462
170Ovarian steroidogenesis_Homo sapiens_hsa049130.15937515

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