TMEM151A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.13104964
2axon ensheathment in central nervous system (GO:0032291)8.13104964
3synaptic vesicle docking involved in exocytosis (GO:0016081)7.89988718
4sodium ion export (GO:0071436)5.03378845
5myelination (GO:0042552)4.78344043
6ensheathment of neurons (GO:0007272)4.76722200
7axon ensheathment (GO:0008366)4.76722200
8fatty acid elongation (GO:0030497)4.74552937
9long-chain fatty acid biosynthetic process (GO:0042759)4.55680212
10neuronal action potential propagation (GO:0019227)4.50365949
11synaptic vesicle maturation (GO:0016188)4.39286196
12positive regulation of synapse maturation (GO:0090129)4.36092825
13postsynaptic membrane organization (GO:0001941)4.30550554
14regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.20603627
15neuron cell-cell adhesion (GO:0007158)4.19307114
16negative regulation of neurotransmitter transport (GO:0051589)4.12899536
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.09930699
18regulation of neurotransmitter levels (GO:0001505)4.06590095
19potassium ion homeostasis (GO:0055075)4.05869047
20L-amino acid import (GO:0043092)4.04255979
21positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.03504007
22positive regulation of dendritic spine development (GO:0060999)3.99734600
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98369810
24neurotransmitter-gated ion channel clustering (GO:0072578)3.95752998
25presynaptic membrane organization (GO:0097090)3.95745234
26synaptic vesicle exocytosis (GO:0016079)3.92654588
27negative regulation of neurotransmitter secretion (GO:0046929)3.89592327
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89010695
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.86967153
30potassium ion import (GO:0010107)3.85812440
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.83428159
32positive regulation of neurotransmitter transport (GO:0051590)3.79452031
33glutamate secretion (GO:0014047)3.77752170
34establishment of mitochondrion localization (GO:0051654)3.76192759
35presynaptic membrane assembly (GO:0097105)3.73814089
36synaptic vesicle endocytosis (GO:0048488)3.72033948
37regulation of neurotransmitter transport (GO:0051588)3.70267779
38positive regulation of neurotransmitter secretion (GO:0001956)3.69823691
39regulation of synaptic vesicle exocytosis (GO:2000300)3.65366610
40locomotory exploration behavior (GO:0035641)3.62088225
41myelin maintenance (GO:0043217)3.61620633
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.58912797
43transmission of nerve impulse (GO:0019226)3.54912143
44cerebellar Purkinje cell differentiation (GO:0021702)3.53672452
45vocalization behavior (GO:0071625)3.52872358
46adult walking behavior (GO:0007628)3.52237372
47dendritic spine morphogenesis (GO:0060997)3.48558704
48protein localization to synapse (GO:0035418)3.46134832
49regulation of ARF protein signal transduction (GO:0032012)3.45200975
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44487413
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.43010843
52regulation of neuronal synaptic plasticity (GO:0048168)3.41308667
53negative regulation of dendrite morphogenesis (GO:0050774)3.40139230
54regulation of synapse maturation (GO:0090128)3.39281949
55cell communication by electrical coupling (GO:0010644)3.39247769
56acidic amino acid transport (GO:0015800)3.37021425
57response to methylmercury (GO:0051597)3.34299144
58neuron recognition (GO:0008038)3.33462923
59negative regulation of protein localization to cell surface (GO:2000009)3.28734880
60glycine transport (GO:0015816)3.25712801
61cellular sodium ion homeostasis (GO:0006883)3.25376491
62glutamate receptor signaling pathway (GO:0007215)3.24674160
63neuronal ion channel clustering (GO:0045161)3.23672116
64negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.20869752
65regulation of synaptic transmission (GO:0050804)3.20214475
66membrane depolarization (GO:0051899)3.20209202
67cerebellar Purkinje cell layer development (GO:0021680)3.18193839
68oligodendrocyte differentiation (GO:0048709)3.17384156
69negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16882146
70membrane depolarization during action potential (GO:0086010)3.15686769
71peptidyl-tyrosine autophosphorylation (GO:0038083)3.14110061
72synaptic transmission, glutamatergic (GO:0035249)3.12606972
73neuron-neuron synaptic transmission (GO:0007270)3.11018925
74establishment of synaptic vesicle localization (GO:0097480)3.10335105
75synaptic vesicle transport (GO:0048489)3.10335105
76regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10023932
77regulation of collateral sprouting (GO:0048670)3.10003444
78synaptic transmission (GO:0007268)3.08734656
79regulation of synaptic vesicle transport (GO:1902803)3.08701458
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08671688
81neuromuscular synaptic transmission (GO:0007274)3.08209239
82gamma-aminobutyric acid transport (GO:0015812)3.07516267
83gamma-aminobutyric acid signaling pathway (GO:0007214)3.06730570
84proline transport (GO:0015824)3.03526369
85amino acid import (GO:0043090)3.01906226
86detection of calcium ion (GO:0005513)3.01651656
87L-glutamate transport (GO:0015813)3.00569332
88glycerophospholipid catabolic process (GO:0046475)3.00372866
89regulation of glutamate receptor signaling pathway (GO:1900449)2.99699555
90regulation of synaptic transmission, glutamatergic (GO:0051966)2.99679688
91apical protein localization (GO:0045176)2.99558748
92G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98039803
93negative regulation of axonogenesis (GO:0050771)2.96911557
94vesicle docking involved in exocytosis (GO:0006904)2.96820417
95axonal fasciculation (GO:0007413)2.94751540
96substantia nigra development (GO:0021762)2.90824840
97dicarboxylic acid transport (GO:0006835)2.90746654
98mating behavior (GO:0007617)2.90275887
99layer formation in cerebral cortex (GO:0021819)2.89419445
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87067235
101regulation of excitatory postsynaptic membrane potential (GO:0060079)2.86967035
102regulation of dendritic spine morphogenesis (GO:0061001)2.85914922
103detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.85831219
104detection of temperature stimulus involved in sensory perception (GO:0050961)2.85831219
105positive regulation of membrane potential (GO:0045838)2.84484054
106exploration behavior (GO:0035640)2.84164861
107neuron remodeling (GO:0016322)2.84142378
108neuromuscular process controlling posture (GO:0050884)2.82818234
109regulation of voltage-gated calcium channel activity (GO:1901385)2.81857826
110long-term memory (GO:0007616)2.79350619
111eye photoreceptor cell differentiation (GO:0001754)2.78789384
112photoreceptor cell differentiation (GO:0046530)2.78789384
113neurotransmitter secretion (GO:0007269)2.78167107
114nerve growth factor signaling pathway (GO:0038180)2.77297815
115astrocyte development (GO:0014002)2.77030620
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77026342
117neurotransmitter uptake (GO:0001504)2.77024566
118membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76965932
119cellular potassium ion homeostasis (GO:0030007)2.76617912
120regulation of synaptic plasticity (GO:0048167)2.73015484
121cerebellar granule cell differentiation (GO:0021707)2.71996114
122regulation of glutamate secretion (GO:0014048)2.71944956
123asymmetric protein localization (GO:0008105)2.70702637
124regulation of postsynaptic membrane potential (GO:0060078)2.69133642
125neurotransmitter transport (GO:0006836)2.67902570
126dendrite morphogenesis (GO:0048813)2.67895513
127cerebral cortex radially oriented cell migration (GO:0021799)2.67328608
128regulation of dendritic spine development (GO:0060998)2.65825710
129membrane hyperpolarization (GO:0060081)2.65761419
130long-term synaptic potentiation (GO:0060291)2.64822155
131regulation of neurotransmitter secretion (GO:0046928)2.60930602
132membrane tubulation (GO:0097320)2.60550866
133cholesterol biosynthetic process (GO:0006695)2.59868782
134neuromuscular process controlling balance (GO:0050885)2.59299079
135regulation of vesicle fusion (GO:0031338)2.58736574
136regulation of synapse structural plasticity (GO:0051823)2.56033655
137auditory behavior (GO:0031223)2.55841875
138regulation of catecholamine metabolic process (GO:0042069)2.54987254
139regulation of dopamine metabolic process (GO:0042053)2.54987254
140adult locomotory behavior (GO:0008344)2.54755966
141dendritic spine organization (GO:0097061)2.54418865

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75473633
2GBX2_23144817_ChIP-Seq_PC3_Human3.45865074
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99114444
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91618790
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91445416
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58153672
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58153672
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.48249356
9* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47202895
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.44667359
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42525547
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42467875
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41446549
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41190017
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38108518
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.23937713
17* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20645900
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18874694
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.14239649
20DROSHA_22980978_ChIP-Seq_HELA_Human2.13199099
21REST_21632747_ChIP-Seq_MESCs_Mouse2.13171832
22TAF15_26573619_Chip-Seq_HEK293_Human2.11519743
23RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.06696275
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.03441751
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96242368
26AR_21572438_ChIP-Seq_LNCaP_Human1.93425517
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76718424
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.76352626
29KDM2B_26808549_Chip-Seq_K562_Human1.70111908
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68500737
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65651157
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64853800
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63405369
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59164913
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57360625
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49186265
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48159938
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46416358
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45698227
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41821905
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41748379
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.40457164
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40070456
44TET1_21490601_ChIP-Seq_MESCs_Mouse1.39611643
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39468913
46VDR_22108803_ChIP-Seq_LS180_Human1.39105566
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.38486314
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37445444
49SMAD4_21799915_ChIP-Seq_A2780_Human1.35013216
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34701803
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34495975
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34036360
53CTCF_27219007_Chip-Seq_Bcells_Human1.33924346
54P300_19829295_ChIP-Seq_ESCs_Human1.32651389
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32538674
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29699843
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28222634
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.27268259
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26794795
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26325608
61ER_23166858_ChIP-Seq_MCF-7_Human1.24305337
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23614670
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23545050
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.21528714
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17406413
66STAT3_23295773_ChIP-Seq_U87_Human1.16876197
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15815725
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15760528
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14971932
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13794944
71* RING1B_27294783_Chip-Seq_ESCs_Mouse1.13202142
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13081507
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12854305
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12637210
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12198463
76LXR_22292898_ChIP-Seq_THP-1_Human1.07910818
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07693523
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07243847
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.06962682
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.05766335
81RNF2_27304074_Chip-Seq_NSC_Mouse1.05434481
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.03634419
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03632343
84TCF4_23295773_ChIP-Seq_U87_Human1.02643991
85* OCT4_19829295_ChIP-Seq_ESCs_Human1.01948660
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.01890502
87FUS_26573619_Chip-Seq_HEK293_Human1.01365326
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.00274857
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98627878
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98329735
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98226233
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.96896847
93DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96581747
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96171172
95ZNF274_21170338_ChIP-Seq_K562_Hela0.95080478
96AR_25329375_ChIP-Seq_VCAP_Human0.94885195
97AHR_22903824_ChIP-Seq_MCF-7_Human0.94802583
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93594870
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93511396
100DPY_21335234_ChIP-Seq_ESCs_Mouse0.92819115
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92638291
102ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91777045
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91090569
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91041194
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90937277
106RUNX2_22187159_ChIP-Seq_PCA_Human0.90823360
107* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90610947
108NANOG_18555785_Chip-Seq_ESCs_Mouse0.90153871
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89980972
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89485029
111TP53_16413492_ChIP-PET_HCT116_Human0.89343386
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88571112
113EP300_21415370_ChIP-Seq_HL-1_Mouse0.87402351
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86873332
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86368391
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86144090
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85767625
118NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85767625
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85257893
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.85174129
121AR_19668381_ChIP-Seq_PC3_Human0.84748123
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84729873
123IGF1R_20145208_ChIP-Seq_DFB_Human0.84341719
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.84165372
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.83776367
126LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83529524
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82699677
128* SMC4_20622854_ChIP-Seq_HELA_Human0.82514713
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.81562917
130JUN_21703547_ChIP-Seq_K562_Human0.81332115
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81230348
132SMAD4_21741376_ChIP-Seq_ESCs_Human0.79851404
133KLF4_19829295_ChIP-Seq_ESCs_Human0.79116230
134MYC_19915707_ChIP-ChIP_AK7_Human0.77474829
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77191496
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.73197447
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73154879
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.72039120
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.70266312
140* CREB1_26743006_Chip-Seq_LNCaP_Human0.69652182
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.69552490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.96928758
2MP0004859_abnormal_synaptic_plasticity4.94226141
3MP0004270_analgesia4.05591042
4MP0000920_abnormal_myelination3.51945019
5MP0003635_abnormal_synaptic_transmissio3.34268483
6MP0002064_seizures3.04753032
7MP0002272_abnormal_nervous_system2.95549602
8MP0009745_abnormal_behavioral_response2.93489589
9MP0001486_abnormal_startle_reflex2.76571918
10MP0005423_abnormal_somatic_nervous2.70692441
11MP0003329_amyloid_beta_deposits2.67494459
12MP0009046_muscle_twitch2.61642109
13MP0002063_abnormal_learning/memory/cond2.60489103
14MP0002734_abnormal_mechanical_nocicepti2.54043498
15MP0001968_abnormal_touch/_nociception2.53738332
16MP0002572_abnormal_emotion/affect_behav2.34073466
17MP0001529_abnormal_vocalization2.22174561
18MP0003690_abnormal_glial_cell2.14967459
19MP0001905_abnormal_dopamine_level2.14311339
20MP0003787_abnormal_imprinting2.13403456
21MP0002822_catalepsy2.13214080
22MP0004885_abnormal_endolymph2.08207671
23MP0000778_abnormal_nervous_system2.06577842
24MP0002735_abnormal_chemical_nociception2.05739206
25MP0001970_abnormal_pain_threshold2.00404932
26MP0002736_abnormal_nociception_after2.00095463
27MP0004142_abnormal_muscle_tone1.97344872
28MP0002733_abnormal_thermal_nociception1.95517428
29MP0001440_abnormal_grooming_behavior1.94504343
30MP0004742_abnormal_vestibular_system1.88182428
31MP0002067_abnormal_sensory_capabilities1.79623455
32MP0008569_lethality_at_weaning1.77121283
33MP0003634_abnormal_glial_cell1.76857697
34MP0003950_abnormal_plasma_membrane1.72401398
35MP0001501_abnormal_sleep_pattern1.70030876
36MP0000955_abnormal_spinal_cord1.67243302
37MP0004924_abnormal_behavior1.59408608
38MP0005386_behavior/neurological_phenoty1.59408608
39MP0005409_darkened_coat_color1.59082136
40MP0002229_neurodegeneration1.57945433
41MP0001485_abnormal_pinna_reflex1.54834372
42MP0003123_paternal_imprinting1.54759209
43MP0002882_abnormal_neuron_morphology1.53449230
44MP0005171_absent_coat_pigmentation1.51232773
45MP0003633_abnormal_nervous_system1.50873650
46MP0002066_abnormal_motor_capabilities/c1.48650291
47MP0003631_nervous_system_phenotype1.45337946
48MP0002184_abnormal_innervation1.44194042
49MP0003632_abnormal_nervous_system1.39710606
50MP0006276_abnormal_autonomic_nervous1.33467377
51MP0004811_abnormal_neuron_physiology1.32704814
52MP0000604_amyloidosis1.31495562
53MP0002557_abnormal_social/conspecific_i1.29963841
54MP0005410_abnormal_fertilization1.23848829
55MP0009780_abnormal_chondrocyte_physiolo1.22345632
56MP0004858_abnormal_nervous_system1.22053282
57MP0005551_abnormal_eye_electrophysiolog1.16974744
58MP0003136_yellow_coat_color1.14778444
59MP0004145_abnormal_muscle_electrophysio1.13570132
60MP0005646_abnormal_pituitary_gland1.10895494
61MP0001963_abnormal_hearing_physiology1.09952706
62MP0002638_abnormal_pupillary_reflex1.06205354
63MP0002752_abnormal_somatic_nervous1.04629083
64MP0001502_abnormal_circadian_rhythm1.03825477
65MP0004043_abnormal_pH_regulation1.03645744
66MP0002152_abnormal_brain_morphology1.01436331
67MP0005645_abnormal_hypothalamus_physiol0.99079140
68MP0010386_abnormal_urinary_bladder0.98170634
69MP0001984_abnormal_olfaction0.95275751
70MP0000747_muscle_weakness0.95101416
71MP0005623_abnormal_meninges_morphology0.94064447
72MP0001177_atelectasis0.93794205
73MP0001299_abnormal_eye_distance/0.85937447
74MP0008874_decreased_physiological_sensi0.82687387
75MP0000751_myopathy0.82161669
76MP0003879_abnormal_hair_cell0.81688412
77MP0000462_abnormal_digestive_system0.81345635
78MP0005167_abnormal_blood-brain_barrier0.79382732
79MP0003283_abnormal_digestive_organ0.78804904
80MP0001188_hyperpigmentation0.77958609
81MP0003075_altered_response_to0.77182819
82MP0008260_abnormal_autophagy0.75239908
83MP0003121_genomic_imprinting0.75175314
84MP0010678_abnormal_skin_adnexa0.73820490
85MP0008877_abnormal_DNA_methylation0.73602669
86MP0002069_abnormal_eating/drinking_beha0.71863652
87MP0002090_abnormal_vision0.69587353
88MP0003172_abnormal_lysosome_physiology0.69453999
89MP0004134_abnormal_chest_morphology0.69047905
90MP0001348_abnormal_lacrimal_gland0.68511235
91MP0003938_abnormal_ear_development0.65459111
92MP0008872_abnormal_physiological_respon0.64532434
93MP0000026_abnormal_inner_ear0.64406582
94MP0003137_abnormal_impulse_conducting0.63407208
95MP0001664_abnormal_digestion0.63367222
96MP0000631_abnormal_neuroendocrine_gland0.63101132
97MP0004085_abnormal_heartbeat0.62987139
98MP0005195_abnormal_posterior_eye0.59028716
99MP0003122_maternal_imprinting0.58513648
100MP0001986_abnormal_taste_sensitivity0.57682285
101MP0001943_abnormal_respiration0.57150058
102MP0000013_abnormal_adipose_tissue0.55267128
103MP0002909_abnormal_adrenal_gland0.54681125
104MP0010769_abnormal_survival0.54525883
105MP0005535_abnormal_body_temperature0.54025547
106MP0004147_increased_porphyrin_level0.53624592
107MP0010770_preweaning_lethality0.52054181
108MP0002082_postnatal_lethality0.52054181
109MP0010768_mortality/aging0.51207514
110MP0004130_abnormal_muscle_cell0.50893459
111MP0003956_abnormal_body_size0.50646064
112MP0001346_abnormal_lacrimal_gland0.50465655
113MP0006072_abnormal_retinal_apoptosis0.50193207
114MP0004036_abnormal_muscle_relaxation0.49695842
115MP0003861_abnormal_nervous_system0.49571417
116MP0000639_abnormal_adrenal_gland0.49521663
117MP0000579_abnormal_nail_morphology0.47151077
118MP0000566_synostosis0.43395128
119MP0003183_abnormal_peptide_metabolism0.43262073

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.94959870
2Neurofibrillary tangles (HP:0002185)5.57230641
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.18270171
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.18270171
5Focal motor seizures (HP:0011153)5.14499356
6Supranuclear gaze palsy (HP:0000605)4.48675062
7Cerebral inclusion bodies (HP:0100314)4.40192852
8Abnormality of the corticospinal tract (HP:0002492)4.39240929
9Peripheral hypomyelination (HP:0007182)4.09200588
10Focal seizures (HP:0007359)3.90506011
11Ankle clonus (HP:0011448)3.87492832
12Spastic gait (HP:0002064)3.79004474
13Dysmetria (HP:0001310)3.77826353
14Insidious onset (HP:0003587)3.68948681
15Termporal pattern (HP:0011008)3.68948681
16Sensory axonal neuropathy (HP:0003390)3.66575025
17Onion bulb formation (HP:0003383)3.49243049
18Epileptic encephalopathy (HP:0200134)3.43873150
19Atonic seizures (HP:0010819)3.41434469
20Action tremor (HP:0002345)3.32299766
21Intention tremor (HP:0002080)3.28216025
22Cerebral hypomyelination (HP:0006808)3.25661807
23Scanning speech (HP:0002168)3.19906241
24Epileptiform EEG discharges (HP:0011182)3.17817042
25Papilledema (HP:0001085)3.06926856
26Tetraplegia (HP:0002445)3.04970122
27Obstructive sleep apnea (HP:0002870)2.95977261
28Pheochromocytoma (HP:0002666)2.95813910
29Parakeratosis (HP:0001036)2.95684525
30Visual hallucinations (HP:0002367)2.95559923
31Retinal dysplasia (HP:0007973)2.91523244
32EEG with generalized epileptiform discharges (HP:0011198)2.88554011
33Craniofacial dystonia (HP:0012179)2.87963118
34Annular pancreas (HP:0001734)2.87429130
35Status epilepticus (HP:0002133)2.81067543
36Progressive cerebellar ataxia (HP:0002073)2.80335977
37Hemiplegia (HP:0002301)2.76973006
38Hypsarrhythmia (HP:0002521)2.72021504
39Dialeptic seizures (HP:0011146)2.71277077
40Urinary urgency (HP:0000012)2.70833107
41Sleep apnea (HP:0010535)2.69682345
42Bradykinesia (HP:0002067)2.67605978
43Abnormal auditory evoked potentials (HP:0006958)2.65680346
44Polyphagia (HP:0002591)2.65258557
45Lower limb muscle weakness (HP:0007340)2.62020732
46Generalized tonic-clonic seizures (HP:0002069)2.56978692
47Neuroendocrine neoplasm (HP:0100634)2.56843595
48Apathy (HP:0000741)2.55988201
49Broad-based gait (HP:0002136)2.55367611
50Urinary bladder sphincter dysfunction (HP:0002839)2.53784104
51Absence seizures (HP:0002121)2.53626447
52Slow saccadic eye movements (HP:0000514)2.50809428
53Dysdiadochokinesis (HP:0002075)2.45936309
54Insomnia (HP:0100785)2.44515516
55Megalencephaly (HP:0001355)2.43507912
56Akinesia (HP:0002304)2.40453015
57Anxiety (HP:0000739)2.39814462
58Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39576656
59Alacrima (HP:0000522)2.38578648
60Gaze-evoked nystagmus (HP:0000640)2.35889777
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34998779
62Limb dystonia (HP:0002451)2.31384873
63Diminished motivation (HP:0000745)2.31175395
64Febrile seizures (HP:0002373)2.29901369
65Clumsiness (HP:0002312)2.29799084
66Truncal ataxia (HP:0002078)2.27811900
67Leukodystrophy (HP:0002415)2.25655780
68Abnormal social behavior (HP:0012433)2.24403659
69Impaired social interactions (HP:0000735)2.24403659
70Thickened helices (HP:0000391)2.23849198
71Hyperventilation (HP:0002883)2.22794039
72Clonus (HP:0002169)2.21890302
73Cerebral hemorrhage (HP:0001342)2.21355022
74Impaired vibration sensation in the lower limbs (HP:0002166)2.21232641
75Generalized myoclonic seizures (HP:0002123)2.20520874
76Abnormal eating behavior (HP:0100738)2.17004959
77Segmental peripheral demyelination/remyelination (HP:0003481)2.16602482
78Aplasia involving bones of the upper limbs (HP:0009823)2.15335031
79Aplasia of the phalanges of the hand (HP:0009802)2.15335031
80Aplasia involving bones of the extremities (HP:0009825)2.15335031
81Increased circulating renin level (HP:0000848)2.14631091
82CNS hypomyelination (HP:0003429)2.14081519
83Hammertoe (HP:0001765)2.12489016
84Foot dorsiflexor weakness (HP:0009027)2.11601796
85Impaired vibratory sensation (HP:0002495)2.10848569
86Mutism (HP:0002300)2.10746335
87Postural instability (HP:0002172)2.10697490
88Rapidly progressive (HP:0003678)2.09702040
89Neuronal loss in central nervous system (HP:0002529)2.09211777
90Abnormality of the lower motor neuron (HP:0002366)2.08624760
91Spastic tetraparesis (HP:0001285)2.06546791
92Impaired smooth pursuit (HP:0007772)2.06255764
93Delusions (HP:0000746)2.05692562
94Progressive inability to walk (HP:0002505)2.05466312
95Torticollis (HP:0000473)2.04404040
96Depression (HP:0000716)2.02678289
97Incomplete penetrance (HP:0003829)2.02527337
98Bowel incontinence (HP:0002607)2.01404644
99Decreased motor nerve conduction velocity (HP:0003431)2.00978950
100Ventricular fibrillation (HP:0001663)1.99217952
101Hemiparesis (HP:0001269)1.98066443
102Distal sensory impairment (HP:0002936)1.95113446
103Poor speech (HP:0002465)1.93911117
104Poor eye contact (HP:0000817)1.92638385
105Abnormality of the foot musculature (HP:0001436)1.91779932
106Abnormality of saccadic eye movements (HP:0000570)1.88705085
107Stereotypic behavior (HP:0000733)1.88034301
108Type II lissencephaly (HP:0007260)1.87755314
109Abnormal large intestine physiology (HP:0012700)1.86602160
110Morphological abnormality of the pyramidal tract (HP:0002062)1.86314019
111Abnormality of binocular vision (HP:0011514)1.85064225
112Diplopia (HP:0000651)1.85064225
113Abnormality of ocular smooth pursuit (HP:0000617)1.84585033
114Absent speech (HP:0001344)1.83130064
115Abnormality of the periventricular white matter (HP:0002518)1.82982382
116Amblyopia (HP:0000646)1.82247052
117Autoamputation (HP:0001218)1.80875071
118Decreased lacrimation (HP:0000633)1.80660597
119Metabolic alkalosis (HP:0200114)1.80579235
120Focal dystonia (HP:0004373)1.80395557
121Diminished movement (HP:0002374)1.79219913
122Anteriorly placed anus (HP:0001545)1.78155476
123Rigidity (HP:0002063)1.77968291
124Choreoathetosis (HP:0001266)1.77782978
125Amyotrophic lateral sclerosis (HP:0007354)1.77172353
126Excessive salivation (HP:0003781)1.77051140
127Drooling (HP:0002307)1.77051140
128Split foot (HP:0001839)1.76175746
129Fetal akinesia sequence (HP:0001989)1.75395259
130Muscular hypotonia of the trunk (HP:0008936)1.75369910
131Psychosis (HP:0000709)1.74698640
132Spinal canal stenosis (HP:0003416)1.74649417
133Dementia (HP:0000726)1.72901609
134Spastic tetraplegia (HP:0002510)1.72410592
135Bundle branch block (HP:0011710)1.72400754
136Memory impairment (HP:0002354)1.70646743
137Lower limb amyotrophy (HP:0007210)1.69173897
138Lower limb asymmetry (HP:0100559)1.67718136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.25809856
2EPHA43.35997319
3OXSR13.29893791
4NTRK32.60464951
5MAP3K92.39469362
6NTRK12.30022065
7CDK192.28635495
8PAK62.13909357
9MAPKAPK52.08305357
10PNCK2.06902588
11MARK11.93025604
12UHMK11.92543691
13PKN11.91644855
14PRPF4B1.88424503
15EPHB11.83201888
16CASK1.81777718
17TNIK1.80877126
18KSR21.79325819
19WNK41.74185774
20BCR1.70191969
21MAP3K41.61086165
22MINK11.58377671
23CAMK2B1.53586362
24WNK11.52495882
25ARAF1.50768584
26SIK21.48688478
27DAPK21.44650200
28LIMK11.42785755
29CDK51.40297917
30LATS21.36517673
31DAPK11.32206198
32NEK61.31208526
33PRKD31.30749309
34NTRK21.30417959
35FGFR21.29141875
36SGK4941.28123856
37SGK2231.28123856
38TYRO31.27251489
39MAP2K71.26901907
40ROCK21.21755341
41FGR1.19005593
42CSNK1G21.17449651
43CSNK1G31.17079736
44CAMK2A1.13942718
45CAMK2D1.13610122
46GRK51.11760700
47ALK1.09971439
48RIPK41.09506188
49MET1.08085458
50CSNK1A1L1.05987956
51CDK141.05973822
52MAP3K131.04460169
53MARK21.01893403
54RIPK11.01420209
55PBK1.01392118
56PAK30.99804394
57CDK150.99697748
58CAMK2G0.97640657
59PHKG10.96857802
60PHKG20.96857802
61CDK180.96571908
62MAPK130.96482101
63PLK20.95369481
64MAP3K20.95007965
65FES0.94000264
66TESK20.89555983
67CDK11A0.88677036
68MAPK120.86787452
69STK380.84971456
70MAP3K110.83763707
71MAP2K40.83229724
72CSNK1G10.80616859
73PDPK10.79539025
74SGK20.79294664
75PTK2B0.73712250
76BRSK10.73487384
77CLK10.73321038
78ICK0.72355583
79STK110.72059474
80PRKCG0.71687884
81PRKCE0.71551898
82CAMKK10.68857310
83PINK10.68080290
84TESK10.66984208
85SGK30.65853990
86MUSK0.65810651
87PRKCH0.64819667
88KSR10.61492492
89BMPR20.61262916
90FYN0.58638369
91PRKCQ0.57972861
92BRAF0.57377453
93CAMK40.57350335
94PDK10.56968725
95CAMK10.56314432
96PRKD10.56088074
97MAP3K120.55961539
98RPS6KA30.55663613
99RET0.54590347
100DAPK30.54243088
101DYRK1A0.51407571
102CAMKK20.50637027
103CAMK1G0.50506554
104DYRK20.49688786
105TNK20.46792691
106MAP3K10.45111057
107SGK10.43339192
108CSNK1A10.41122786
109RAF10.40638334
110NME10.40583497
111PRKG10.40523409
112MAPK100.39738812
113GRK70.38780884
114DMPK0.38669040
115PRKCA0.37320025
116MST40.35275029
117ADRBK20.35119575
118PRKCZ0.34426606
119PRKG20.34207811
120ROCK10.33605604
121LMTK20.28338851
122PRKACA0.27877431
123MAPK80.26250499
124MAPK40.25689510

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.99338277
2Nicotine addiction_Homo sapiens_hsa050332.67840174
3Synaptic vesicle cycle_Homo sapiens_hsa047212.57370040
4GABAergic synapse_Homo sapiens_hsa047272.47035207
5Glutamatergic synapse_Homo sapiens_hsa047242.44171829
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31115149
7Steroid biosynthesis_Homo sapiens_hsa001002.19482861
8Morphine addiction_Homo sapiens_hsa050322.18126474
9Fatty acid elongation_Homo sapiens_hsa000622.16269046
10Circadian entrainment_Homo sapiens_hsa047132.15360402
11Olfactory transduction_Homo sapiens_hsa047401.99665743
12Salivary secretion_Homo sapiens_hsa049701.86690385
13Long-term potentiation_Homo sapiens_hsa047201.86535380
14Serotonergic synapse_Homo sapiens_hsa047261.83051753
15Amphetamine addiction_Homo sapiens_hsa050311.81604211
16Dopaminergic synapse_Homo sapiens_hsa047281.78524048
17Ether lipid metabolism_Homo sapiens_hsa005651.77527592
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76518207
19Long-term depression_Homo sapiens_hsa047301.73335825
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68661397
21Axon guidance_Homo sapiens_hsa043601.66284809
22Gastric acid secretion_Homo sapiens_hsa049711.65820653
23Collecting duct acid secretion_Homo sapiens_hsa049661.63407403
24Cholinergic synapse_Homo sapiens_hsa047251.57793732
25Cocaine addiction_Homo sapiens_hsa050301.57040942
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45817192
27Nitrogen metabolism_Homo sapiens_hsa009101.44431134
28Taste transduction_Homo sapiens_hsa047421.44292171
29Oxidative phosphorylation_Homo sapiens_hsa001901.40891308
30Insulin secretion_Homo sapiens_hsa049111.40512830
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37813200
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.35640456
33Renin secretion_Homo sapiens_hsa049241.34236915
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29496386
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28611711
36Vibrio cholerae infection_Homo sapiens_hsa051101.21727489
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18786547
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17731804
39Alzheimers disease_Homo sapiens_hsa050101.17715364
40Cardiac muscle contraction_Homo sapiens_hsa042601.17374304
41Oxytocin signaling pathway_Homo sapiens_hsa049211.16911196
42Gap junction_Homo sapiens_hsa045401.16194061
43Calcium signaling pathway_Homo sapiens_hsa040201.15417664
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08557562
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07823324
46Parkinsons disease_Homo sapiens_hsa050121.07413200
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.02975449
48GnRH signaling pathway_Homo sapiens_hsa049121.02567722
49cAMP signaling pathway_Homo sapiens_hsa040240.99670994
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98871867
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97442634
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.94355555
53ErbB signaling pathway_Homo sapiens_hsa040120.93152179
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.92881592
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92660108
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92618609
57Phototransduction_Homo sapiens_hsa047440.91425283
58Dorso-ventral axis formation_Homo sapiens_hsa043200.90000758
59Sphingolipid metabolism_Homo sapiens_hsa006000.89774851
60Pancreatic secretion_Homo sapiens_hsa049720.87596668
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86550209
62Bile secretion_Homo sapiens_hsa049760.84918147
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83112982
64Renal cell carcinoma_Homo sapiens_hsa052110.82775198
65Melanogenesis_Homo sapiens_hsa049160.82335677
66Ras signaling pathway_Homo sapiens_hsa040140.77137691
67Vitamin B6 metabolism_Homo sapiens_hsa007500.76901682
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75296448
69Endocytosis_Homo sapiens_hsa041440.74361841
70Butanoate metabolism_Homo sapiens_hsa006500.72150211
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70608557
72Estrogen signaling pathway_Homo sapiens_hsa049150.70570484
73Choline metabolism in cancer_Homo sapiens_hsa052310.67758243
74Arginine and proline metabolism_Homo sapiens_hsa003300.67418353
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.65180694
76Sulfur metabolism_Homo sapiens_hsa009200.64370912
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63067787
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.61283064
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60616327
80beta-Alanine metabolism_Homo sapiens_hsa004100.60530443
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59722219
82Ovarian steroidogenesis_Homo sapiens_hsa049130.59621404
83Tight junction_Homo sapiens_hsa045300.59592843
84MAPK signaling pathway_Homo sapiens_hsa040100.58613484
85Glioma_Homo sapiens_hsa052140.56027244
86Linoleic acid metabolism_Homo sapiens_hsa005910.54974533
87Thyroid hormone synthesis_Homo sapiens_hsa049180.53569767
88Glucagon signaling pathway_Homo sapiens_hsa049220.52365031
89Rheumatoid arthritis_Homo sapiens_hsa053230.52171715
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51103372
91Type II diabetes mellitus_Homo sapiens_hsa049300.50580560
92Mineral absorption_Homo sapiens_hsa049780.50263740
93Huntingtons disease_Homo sapiens_hsa050160.49417982
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47567947
95Dilated cardiomyopathy_Homo sapiens_hsa054140.47286265
96Prion diseases_Homo sapiens_hsa050200.46564121
97Alcoholism_Homo sapiens_hsa050340.46550847
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46214436
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44490775
100Circadian rhythm_Homo sapiens_hsa047100.43494260
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43223257
102Histidine metabolism_Homo sapiens_hsa003400.42102099
103Rap1 signaling pathway_Homo sapiens_hsa040150.41412143
104VEGF signaling pathway_Homo sapiens_hsa043700.38245118
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37853119
106Inositol phosphate metabolism_Homo sapiens_hsa005620.36870929
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35627319
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35603730
109Oocyte meiosis_Homo sapiens_hsa041140.35578739
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35389532
111Arginine biosynthesis_Homo sapiens_hsa002200.31142683
112mTOR signaling pathway_Homo sapiens_hsa041500.28253625
113AMPK signaling pathway_Homo sapiens_hsa041520.28216193
114Wnt signaling pathway_Homo sapiens_hsa043100.28065322
115Insulin signaling pathway_Homo sapiens_hsa049100.26883159
116Fatty acid biosynthesis_Homo sapiens_hsa000610.25540105
117Regulation of autophagy_Homo sapiens_hsa041400.24904079
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23660075
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23616327
120Hippo signaling pathway_Homo sapiens_hsa043900.21272710

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