TMEM154

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44544287
2leukocyte aggregation (GO:0070486)5.25254432
3microglial cell activation (GO:0001774)5.11887540
4regulation of B cell receptor signaling pathway (GO:0050855)5.02674269
5positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.91746547
6neutrophil activation involved in immune response (GO:0002283)4.75003261
7positive regulation of gamma-delta T cell activation (GO:0046645)4.74290515
8negative regulation of lymphocyte mediated immunity (GO:0002707)4.36812991
9neutrophil activation (GO:0042119)4.29546055
10cellular extravasation (GO:0045123)4.29273414
11macrophage activation (GO:0042116)4.28855416
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.17239553
13negative regulation of interleukin-12 production (GO:0032695)4.14740026
14granulocyte activation (GO:0036230)4.01974333
15respiratory burst (GO:0045730)4.00037878
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.93849814
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.93849814
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.93849814
19modulation by symbiont of host immune response (GO:0052553)3.93849814
20positive regulation by symbiont of host defense response (GO:0052509)3.93849814
21modulation by symbiont of host defense response (GO:0052031)3.93849814
22response to peptidoglycan (GO:0032494)3.80735312
23interferon-gamma production (GO:0032609)3.72205413
24antigen processing and presentation of endogenous antigen (GO:0019883)3.70145676
25polyketide metabolic process (GO:0030638)3.69622750
26doxorubicin metabolic process (GO:0044598)3.69622750
27daunorubicin metabolic process (GO:0044597)3.69622750
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68096093
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68096093
30leukocyte migration involved in inflammatory response (GO:0002523)3.65434747
31negative regulation of leukocyte mediated immunity (GO:0002704)3.64121067
32myeloid leukocyte mediated immunity (GO:0002444)3.62512574
33immunoglobulin mediated immune response (GO:0016064)3.62050265
34positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.59819086
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.56569512
36antigen processing and presentation via MHC class Ib (GO:0002475)3.56229167
37regulation of B cell differentiation (GO:0045577)3.54180263
38regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.53396700
39superoxide anion generation (GO:0042554)3.52331079
40positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.51139781
41regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.50839016
42detection of molecule of bacterial origin (GO:0032490)3.48445875
43negative regulation of cell killing (GO:0031342)3.46443362
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46443362
45cellular response to interleukin-15 (GO:0071350)3.45908819
46detection of other organism (GO:0098543)3.44762081
47positive thymic T cell selection (GO:0045059)3.43453988
48T cell migration (GO:0072678)3.39588388
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.36350012
50negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.34379090
51negative thymic T cell selection (GO:0045060)3.29208506
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.27706290
53detection of external biotic stimulus (GO:0098581)3.27611888
54response to interleukin-15 (GO:0070672)3.26445055
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25276188
56negative T cell selection (GO:0043383)3.22881013
57positive regulation of antigen processing and presentation (GO:0002579)3.21010026
58detection of bacterium (GO:0016045)3.20931963
59positive regulation of mast cell activation (GO:0033005)3.19325666
60regulation of interferon-beta biosynthetic process (GO:0045357)3.19253448
61negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18347088
62negative regulation of T-helper cell differentiation (GO:0045623)3.18347088
63regulation of interleukin-12 biosynthetic process (GO:0045075)3.17792641
64myeloid cell activation involved in immune response (GO:0002275)3.16857989
65B cell receptor signaling pathway (GO:0050853)3.16134542
66regulation of T cell receptor signaling pathway (GO:0050856)3.14358729
67regulation of interleukin-6 biosynthetic process (GO:0045408)3.14058500
68regulation of gamma-delta T cell activation (GO:0046643)3.12502033
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12131277
70regulation of alpha-beta T cell proliferation (GO:0046640)3.11722053
71negative regulation of adaptive immune response (GO:0002820)3.11406727
72leukocyte degranulation (GO:0043299)3.11158940
73response to host immune response (GO:0052572)3.08913535
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08913535
75neutrophil mediated immunity (GO:0002446)3.07395924
76positive regulation of interferon-alpha production (GO:0032727)3.07349945
77positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07093561
78regulation of T cell mediated cytotoxicity (GO:0001914)3.05853370
79activated T cell proliferation (GO:0050798)3.05679797
80mast cell activation (GO:0045576)3.05139701
81regulation of mast cell activation (GO:0033003)3.04708650
82regulation of tolerance induction (GO:0002643)3.03966939
83positive regulation of T cell mediated cytotoxicity (GO:0001916)3.03921038
84myeloid dendritic cell activation (GO:0001773)3.03351550
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03275443
86regulation of interferon-alpha production (GO:0032647)3.02016237
87positive regulation of B cell differentiation (GO:0045579)3.00993165
88production of molecular mediator involved in inflammatory response (GO:0002532)3.00610910
89regulation of mast cell activation involved in immune response (GO:0033006)3.00218998
90hepatocyte apoptotic process (GO:0097284)2.99232113
91defense response to protozoan (GO:0042832)2.98837199
92regulation of regulatory T cell differentiation (GO:0045589)2.98601426
93response to type I interferon (GO:0034340)2.98572911
94response to muramyl dipeptide (GO:0032495)2.97648711
95leukocyte cell-cell adhesion (GO:0007159)2.97073114
96cellular response to type I interferon (GO:0071357)2.96434830
97type I interferon signaling pathway (GO:0060337)2.96434830
98negative regulation of B cell mediated immunity (GO:0002713)2.96117736
99negative regulation of immunoglobulin mediated immune response (GO:0002890)2.96117736
100interferon-gamma-mediated signaling pathway (GO:0060333)2.96050631
101regulation of gamma-delta T cell differentiation (GO:0045586)2.94833009
102thymic T cell selection (GO:0045061)2.93994636
103cellular response to zinc ion (GO:0071294)2.92739723
104negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.91519569
105macrophage activation involved in immune response (GO:0002281)2.90662786
106positive regulation of toll-like receptor signaling pathway (GO:0034123)2.90580928
107regulation of mast cell degranulation (GO:0043304)2.89894222
108negative regulation of T cell mediated immunity (GO:0002710)2.89868379
109regulation of antigen processing and presentation (GO:0002577)2.87472706
110T-helper 1 type immune response (GO:0042088)2.86995105
111negative regulation of mast cell activation (GO:0033004)2.86766447
112dendritic cell migration (GO:0036336)2.85235959
113tolerance induction (GO:0002507)2.85006516
114response to protozoan (GO:0001562)2.84847980
115detection of biotic stimulus (GO:0009595)2.84791402
116regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84676729
117positive T cell selection (GO:0043368)2.84284735
118dendritic cell chemotaxis (GO:0002407)2.82714235
119T cell selection (GO:0045058)2.82495901
120negative regulation of B cell proliferation (GO:0030889)2.82063610
121myeloid leukocyte activation (GO:0002274)2.79929171
122cellular defense response (GO:0006968)2.78968233
123positive regulation of macrophage differentiation (GO:0045651)2.78418529
124regulation of interleukin-2 biosynthetic process (GO:0045076)2.75464660
125neutrophil chemotaxis (GO:0030593)2.75416734
126response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.74950225
127response to host (GO:0075136)2.74950225
128response to host defenses (GO:0052200)2.74950225
129negative regulation of phagocytosis (GO:0050765)2.72735492
130antigen receptor-mediated signaling pathway (GO:0050851)2.71876507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.94762868
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.68603740
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.66611982
4IRF8_21731497_ChIP-ChIP_J774_Mouse5.43219119
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.04727999
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.00343363
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.79410713
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.65530094
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.54436992
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.49931597
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.26340392
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16374898
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.92490489
14RUNX_20019798_ChIP-Seq_JUKART_Human2.89267885
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85405879
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.83783850
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.78116015
18SCL_19346495_ChIP-Seq_HPC-7_Human2.68039282
19* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46356076
20MYB_26560356_Chip-Seq_TH2_Human2.43564549
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40890300
22* SPI1_23547873_ChIP-Seq_NB4_Human2.37394599
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19972402
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18561611
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.11006802
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01911263
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.97570200
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.94901392
29MYB_26560356_Chip-Seq_TH1_Human1.94727483
30MAF_26560356_Chip-Seq_TH1_Human1.91263213
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86439205
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84934870
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82719809
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.80577546
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77231672
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69296764
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.68575135
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68276633
39VDR_24763502_ChIP-Seq_THP-1_Human1.63324996
40* PU_27001747_Chip-Seq_BMDM_Mouse1.62889653
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60081028
42SPI1_23127762_ChIP-Seq_K562_Human1.53907317
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52513238
44GATA1_22025678_ChIP-Seq_K562_Human1.50918073
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50896870
46VDR_24787735_ChIP-Seq_THP-1_Human1.50602997
47GATA3_26560356_Chip-Seq_TH2_Human1.50041146
48UTX_26944678_Chip-Seq_JUKART_Human1.48205853
49VDR_21846776_ChIP-Seq_THP-1_Human1.46796523
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45424085
51* GATA3_27048872_Chip-Seq_THYMUS_Human1.42494417
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42134844
53* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41945020
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41040401
55* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36734292
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35967345
57* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34429368
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33812565
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.29224350
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24542006
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22974396
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19466323
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17869001
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16822853
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14429428
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13212106
67MYC_22102868_ChIP-Seq_BL_Human1.13043206
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11288309
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04893449
70TCF7_22412390_ChIP-Seq_EML_Mouse1.03679692
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03198910
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02894740
73MAF_26560356_Chip-Seq_TH2_Human0.98613859
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96742648
75GATA1_19941826_ChIP-Seq_K562_Human0.95494072
76RXR_22108803_ChIP-Seq_LS180_Human0.93384970
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.93138361
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91019797
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86416310
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85329060
81* GATA1_19941827_ChIP-Seq_MEL_Mouse0.84939080
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84113249
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83266457
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82031588
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81395917
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81238863
87P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80725880
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79813383
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79344150
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79322509
91* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79052906
92GATA3_26560356_Chip-Seq_TH1_Human0.79042000
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78832252
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78832252
95ESR1_20079471_ChIP-ChIP_T-47D_Human0.78408507
96* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78000578
97* TP63_23658742_ChIP-Seq_EP156T_Human0.77605590
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76931752
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.76403137
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75799925
101ER_23166858_ChIP-Seq_MCF-7_Human0.73831299
102GATA2_19941826_ChIP-Seq_K562_Human0.73343038
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73270072
104* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.72200204
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71577168
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71377866
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71336422
108TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.70634488
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.70406602
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69079917
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68962932
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68955212
113PCGF2_27294783_Chip-Seq_NPCs_Mouse0.68882992
114IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68147013
115* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.66646557
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.65401703
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.65292915
118SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.64652305
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.64551360
120SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.64406828
121* SMRT_27268052_Chip-Seq_Bcells_Human0.63718242
122RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.61592425
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60459267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.45533458
2MP0003436_decreased_susceptibility_to3.73641791
3MP0005671_abnormal_response_to3.45588972
4MP0009785_altered_susceptibility_to3.41993737
5MP0002148_abnormal_hypersensitivity_rea3.17698210
6MP0001790_abnormal_immune_system3.10889999
7MP0005387_immune_system_phenotype3.10889999
8MP0005000_abnormal_immune_tolerance3.04816214
9MP0001800_abnormal_humoral_immune3.02544802
10MP0002419_abnormal_innate_immunity2.97917099
11MP0005025_abnormal_response_to2.88486076
12MP0002452_abnormal_antigen_presenting2.85884794
13MP0000685_abnormal_immune_system2.74413140
14MP0002723_abnormal_immune_serum2.70160780
15MP0003303_peritoneal_inflammation2.69182519
16MP0001819_abnormal_immune_cell2.63842793
17MP0002420_abnormal_adaptive_immunity2.63085148
18MP0003763_abnormal_thymus_physiology2.44400330
19MP0006082_CNS_inflammation2.41749532
20MP0003724_increased_susceptibility_to2.25477541
21MP0002405_respiratory_system_inflammati2.21308293
22MP0002398_abnormal_bone_marrow2.05373578
23MP0005464_abnormal_platelet_physiology2.01393540
24MP0004947_skin_inflammation2.00783595
25MP0000716_abnormal_immune_system2.00105026
26MP0001853_heart_inflammation1.99873426
27MP0010155_abnormal_intestine_physiology1.92472289
28MP0001533_abnormal_skeleton_physiology1.90109712
29MP0002933_joint_inflammation1.90087226
30MP0002006_tumorigenesis1.82435868
31MP0001845_abnormal_inflammatory_respons1.82188199
32MP0004883_abnormal_blood_vessel1.79907488
33MP0005310_abnormal_salivary_gland1.76722586
34MP0005174_abnormal_tail_pigmentation1.73425099
35MP0000569_abnormal_digit_pigmentation1.72055008
36MP0009333_abnormal_splenocyte_physiolog1.71536479
37MP0001873_stomach_inflammation1.64978010
38MP0000689_abnormal_spleen_morphology1.64292175
39MP0002166_altered_tumor_susceptibility1.64041493
40MP0002429_abnormal_blood_cell1.61431745
41MP0004510_myositis1.61168247
42MP0002722_abnormal_immune_system1.61048658
43MP0002396_abnormal_hematopoietic_system1.60618611
44MP0000858_altered_metastatic_potential1.50584402
45MP0002277_abnormal_respiratory_mucosa1.50405784
46MP0009764_decreased_sensitivity_to1.50293794
47MP0009278_abnormal_bone_marrow1.44332998
48MP0004381_abnormal_hair_follicle1.44039987
49MP0005058_abnormal_lysosome_morphology1.41430961
50MP0003183_abnormal_peptide_metabolism1.39611055
51MP0005451_abnormal_body_composition1.37799369
52MP0002998_abnormal_bone_remodeling1.36302356
53MP0005164_abnormal_response_to1.35647494
54MP0003448_altered_tumor_morphology1.35115268
55MP0001545_abnormal_hematopoietic_system1.31898790
56MP0005397_hematopoietic_system_phenotyp1.31898790
57MP0000343_altered_response_to1.30821946
58MP0000465_gastrointestinal_hemorrhage1.28744045
59MP0000490_abnormal_crypts_of1.26011296
60MP0003172_abnormal_lysosome_physiology1.24823659
61MP0000703_abnormal_thymus_morphology1.24818007
62MP0008469_abnormal_protein_level1.23747847
63MP0000015_abnormal_ear_pigmentation1.23705645
64MP0003300_gastrointestinal_ulcer1.21406494
65MP0001851_eye_inflammation1.20649545
66MP0002132_abnormal_respiratory_system1.20245003
67MP0004808_abnormal_hematopoietic_stem1.20042517
68MP0004782_abnormal_surfactant_physiolog1.19626696
69MP0003866_abnormal_defecation1.13777505
70MP0003656_abnormal_erythrocyte_physiolo1.11880637
71MP0003787_abnormal_imprinting1.08845035
72MP0005075_abnormal_melanosome_morpholog1.06736881
73MP0005390_skeleton_phenotype1.06070676
74MP0008004_abnormal_stomach_pH1.04621106
75MP0003828_pulmonary_edema0.97956278
76MP0003453_abnormal_keratinocyte_physiol0.96965509
77MP0002095_abnormal_skin_pigmentation0.96672686
78MP0005166_decreased_susceptibility_to0.95402541
79MP0004484_altered_response_of0.92615802
80MP0003045_fibrosis0.91315817
81MP0003795_abnormal_bone_structure0.91128715
82MP0003566_abnormal_cell_adhesion0.86152485
83MP0003690_abnormal_glial_cell0.83992645
84MP0003221_abnormal_cardiomyocyte_apopto0.82665966
85MP0002332_abnormal_exercise_endurance0.82377282
86MP0001216_abnormal_epidermal_layer0.81860453
87MP0004130_abnormal_muscle_cell0.80730937
88MP0003075_altered_response_to0.79292852
89MP0002928_abnormal_bile_duct0.78074366
90MP0000427_abnormal_hair_cycle0.77989780
91MP0001663_abnormal_digestive_system0.74257549
92MP0003252_abnormal_bile_duct0.72864354
93MP0000371_diluted_coat_color0.71699693
94MP0001191_abnormal_skin_condition0.71676864
95MP0008877_abnormal_DNA_methylation0.70691393
96MP0001986_abnormal_taste_sensitivity0.70599818
97MP0002138_abnormal_hepatobiliary_system0.66858889
98MP0009765_abnormal_xenobiotic_induced0.66569200
99MP0003941_abnormal_skin_development0.65790058
100MP0002254_reproductive_system_inflammat0.64571108
101MP0003279_aneurysm0.63771068
102MP0003191_abnormal_cellular_cholesterol0.62799439
103MP0008057_abnormal_DNA_replication0.60786230
104MP0002133_abnormal_respiratory_system0.60749982
105MP0005388_respiratory_system_phenotype0.60749982
106MP0009763_increased_sensitivity_to0.60399262
107MP0005376_homeostasis/metabolism_phenot0.59316887
108MP0002098_abnormal_vibrissa_morphology0.58704392
109MP0002019_abnormal_tumor_incidence0.57620603
110MP0005167_abnormal_blood-brain_barrier0.56846272
111MP0008260_abnormal_autophagy0.56476925
112MP0000604_amyloidosis0.55595248
113MP0005076_abnormal_cell_differentiation0.54013207
114MP0002060_abnormal_skin_morphology0.53729172
115MP0010386_abnormal_urinary_bladder0.53673718
116MP0002009_preneoplasia0.53627970
117MP0002796_impaired_skin_barrier0.53325055
118MP0000367_abnormal_coat/_hair0.52917063
119MP0006054_spinal_hemorrhage0.52385044
120MP0009931_abnormal_skin_appearance0.52155330
121MP0000372_irregular_coat_pigmentation0.52020538
122MP0001879_abnormal_lymphatic_vessel0.51732270
123MP0000249_abnormal_blood_vessel0.51123968
124MP0005023_abnormal_wound_healing0.50179423

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.31599189
2Eczematoid dermatitis (HP:0000976)6.14610686
3Recurrent bacterial skin infections (HP:0005406)5.43042982
4Gastrointestinal infarctions (HP:0005244)4.57942754
5Myositis (HP:0100614)4.57634512
6Recurrent gram-negative bacterial infections (HP:0005420)4.38211189
7Mediastinal lymphadenopathy (HP:0100721)4.18240118
8Recurrent fungal infections (HP:0002841)4.08088348
9Optic neuritis (HP:0100653)4.01791636
10Retrobulbar optic neuritis (HP:0100654)4.01791636
11Abnormality of macrophages (HP:0004311)3.97659108
12Elevated erythrocyte sedimentation rate (HP:0003565)3.96678866
13Chronic obstructive pulmonary disease (HP:0006510)3.95612210
14Obstructive lung disease (HP:0006536)3.95612210
15Stomatitis (HP:0010280)3.90013239
16Orchitis (HP:0100796)3.79729080
17Recurrent skin infections (HP:0001581)3.77327526
18Recurrent cutaneous fungal infections (HP:0011370)3.62875881
19Chronic mucocutaneous candidiasis (HP:0002728)3.62875881
20Meningitis (HP:0001287)3.57918280
21IgM deficiency (HP:0002850)3.48965414
22Gingivitis (HP:0000230)3.48537372
23Recurrent viral infections (HP:0004429)3.40971280
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.37736105
25Chest pain (HP:0100749)3.35831605
26Agammaglobulinemia (HP:0004432)3.33306208
27Vacuolated lymphocytes (HP:0001922)3.32650622
28Vasculitis (HP:0002633)3.29025965
29Chronic otitis media (HP:0000389)3.26728881
30Recurrent pneumonia (HP:0006532)3.26188705
31Peritonitis (HP:0002586)3.25050545
32Cellulitis (HP:0100658)3.09258364
33Hypochromic microcytic anemia (HP:0004840)3.05686429
34Cheilitis (HP:0100825)2.95475060
35Pustule (HP:0200039)2.92174629
36Urticaria (HP:0001025)2.87951678
37Recurrent bronchitis (HP:0002837)2.85944478
38Anorexia (HP:0002039)2.84943402
39Abnormality of T cell number (HP:0011839)2.84656461
40Recurrent sinusitis (HP:0011108)2.79173459
41Pulmonary infiltrates (HP:0002113)2.78253346
42Pulmonary embolism (HP:0002204)2.77986067
43T lymphocytopenia (HP:0005403)2.77692272
44Parakeratosis (HP:0001036)2.76749200
45Hypochromic anemia (HP:0001931)2.73291353
46Periodontitis (HP:0000704)2.71247920
47Lymphopenia (HP:0001888)2.68927748
48Episodic fever (HP:0001954)2.67678445
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.65696205
50Hemoptysis (HP:0002105)2.65202059
51Recurrent lower respiratory tract infections (HP:0002783)2.63857643
52Thyroiditis (HP:0100646)2.62944221
53Inflammation of the large intestine (HP:0002037)2.62415348
54Prostate neoplasm (HP:0100787)2.61949694
55Interstitial pulmonary disease (HP:0006530)2.61901008
56Chronic diarrhea (HP:0002028)2.61676030
57Abnormality of B cell number (HP:0010975)2.60920987
58B lymphocytopenia (HP:0010976)2.60920987
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.57740643
60Abnormality of T cells (HP:0002843)2.56966977
61Osteomyelitis (HP:0002754)2.56383946
62Petechiae (HP:0000967)2.54643087
63Erythema (HP:0010783)2.54158924
64Keratoconjunctivitis sicca (HP:0001097)2.52685063
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.50759072
66Granulocytopenia (HP:0001913)2.49385286
67Autoimmune thrombocytopenia (HP:0001973)2.47578896
68Subacute progressive viral hepatitis (HP:0006572)2.44326203
69Colitis (HP:0002583)2.44037548
70Arterial thrombosis (HP:0004420)2.43674939
71Increased cerebral lipofuscin (HP:0011813)2.42564483
72Abnormality of the prostate (HP:0008775)2.41592098
73Gastrointestinal inflammation (HP:0004386)2.37526257
74Autoimmune hemolytic anemia (HP:0001890)2.36812535
75Gastrointestinal stroma tumor (HP:0100723)2.36791686
76Abnormality of T cell physiology (HP:0011840)2.36726009
77Prolonged bleeding time (HP:0003010)2.36394079
78Leukocytosis (HP:0001974)2.33319039
79Keratoconjunctivitis (HP:0001096)2.28660406
80Severe combined immunodeficiency (HP:0004430)2.27999251
81Panhypogammaglobulinemia (HP:0003139)2.25811394
82IgG deficiency (HP:0004315)2.25656713
83Gingival bleeding (HP:0000225)2.20585327
84Microcytic anemia (HP:0001935)2.19337177
85Increased IgM level (HP:0003496)2.19294744
86Abnormality of the peritoneum (HP:0002585)2.19143057
87Sepsis (HP:0100806)2.18440598
88Viral hepatitis (HP:0006562)2.18314044
89Increased IgE level (HP:0003212)2.17193078
90Skin ulcer (HP:0200042)2.15004167
91Abnormality of the endocardium (HP:0004306)2.14278994
92Gangrene (HP:0100758)2.13100235
93Basal ganglia calcification (HP:0002135)2.12667144
94Stomach cancer (HP:0012126)2.11760008
95Amyloidosis (HP:0011034)2.11120229
96Epistaxis (HP:0000421)2.11047736
97Hypergammaglobulinemia (HP:0010702)2.09848146
98Acute hepatic failure (HP:0006554)2.09494498
99Abnormality of eosinophils (HP:0001879)2.07673201
100Encephalitis (HP:0002383)2.05186580
101Vertigo (HP:0002321)2.04134105
102Glomerulopathy (HP:0100820)2.03290468
103Papilloma (HP:0012740)2.02953849
104Verrucae (HP:0200043)2.02953849
105Combined immunodeficiency (HP:0005387)1.99482378
106Keratitis (HP:0000491)1.97887654
107Skin rash (HP:0000988)1.97874738
108Slow saccadic eye movements (HP:0000514)1.97381377
109Thick nail (HP:0001805)1.96944321
110Thrombocytosis (HP:0001894)1.96683465
111Arthralgia (HP:0002829)1.96347798
112Eosinophilia (HP:0001880)1.94887758
113IgA deficiency (HP:0002720)1.93647823
114Premature loss of primary teeth (HP:0006323)1.93089355
115Absent frontal sinuses (HP:0002688)1.92777373
116Chronic sinusitis (HP:0011109)1.91529764
117Neoplasm of the tracheobronchial system (HP:0100552)1.91388845
118Restrictive lung disease (HP:0002091)1.90806707
119Joint swelling (HP:0001386)1.88004589
120Abnormality of the pericardium (HP:0001697)1.86078142
121Abnormality of liposaccharide metabolism (HP:0010968)1.85975822
122Abnormality of glycosphingolipid metabolism (HP:0004343)1.85975822
123Abnormality of glycolipid metabolism (HP:0010969)1.85975822
124Ectropion (HP:0000656)1.82085318
125Acne (HP:0001061)1.79352899
126Papilledema (HP:0001085)1.78110069
127Spontaneous hematomas (HP:0007420)1.78002075
128Abnormality of the pleura (HP:0002103)1.76738233
129Polyneuropathy (HP:0001271)1.76358978
130Emphysema (HP:0002097)1.75639658
131Thrombophlebitis (HP:0004418)1.74575437
132Alveolar cell carcinoma (HP:0006519)1.72288511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.96662641
2MAP4K13.85351812
3IRAK43.50244942
4MAP3K143.48364284
5BLK3.00850657
6SIK32.90413159
7IRAK32.67396285
8RIPK42.62604426
9IKBKE2.39503626
10TYK22.38704920
11TBK12.29729027
12TEC2.28409651
13JAK32.25036670
14KIT2.21789803
15FRK1.99141875
16MAP3K131.96206289
17IKBKB1.90233679
18BTK1.88644432
19ZAP701.87009589
20ITK1.85368697
21NME21.70124574
22STK101.69474698
23MAP3K21.66817631
24MAP3K121.65872442
25SYK1.65400604
26JAK11.63763474
27HCK1.47737460
28TRPM71.42835936
29MST41.40305493
30LCK1.36881127
31STK241.35840223
32SIK21.35458715
33CSK1.34274409
34TGFBR21.31683261
35CLK11.26824938
36LYN1.25727723
37MARK31.23658589
38MAP3K31.23368693
39ERN11.22503108
40CSF1R1.21751813
41TAOK11.21724077
42KSR21.21012327
43PTK2B1.17935207
44PIM11.16317980
45CHUK1.14735889
46MAP3K11.14233267
47TAOK31.13863847
48PIM21.13467555
49MAP3K61.12837899
50FGFR31.04910525
51RPS6KA40.96286712
52NLK0.95770287
53WNK10.94576382
54BMPR20.94229149
55MAP2K30.93851516
56ADRBK20.89985672
57YES10.89869823
58FES0.88470981
59NEK90.87934063
60ERBB30.87086275
61TNK20.85590360
62CDK190.79589735
63PDK10.78737719
64CAMKK20.78036326
65SGK30.77690616
66PRKCQ0.76621102
67TAOK20.76492978
68MARK20.75478852
69FGFR40.74287297
70RAF10.73671031
71PIK3CG0.73485809
72MAP2K40.72829029
73STK110.72012018
74GRK60.71609215
75EIF2AK20.70384935
76GRK70.67964895
77IRAK20.67916260
78ACVR1B0.67602085
79SIK10.66490181
80IRAK10.66328888
81JAK20.66109315
82KDR0.64227739
83KSR10.63651932
84MAP3K70.61468764
85PRKG20.60465028
86PTK60.59328872
87STK380.57372630
88EPHB10.55270744
89FLT30.53830188
90LRRK20.52678205
91STK40.52368228
92MATK0.51963948
93FGR0.51738522
94ABL10.51416121
95NUAK10.51334587
96PRKCD0.51206170
97ADRBK10.50749449
98MAP3K110.50367115
99PDPK10.49831279
100PRKD20.47930219
101PRPF4B0.47757538
102GRK10.46397918
103GRK50.44920808
104MAPK120.43578346
105EPHA30.42468812
106BMPR1B0.41786022
107CDK30.41618549
108RPS6KA60.41255611
109MAPKAPK20.40404011
110DYRK30.40166478
111MAPK70.39421443
112SGK4940.39214906
113SGK2230.39214906
114OXSR10.38916225
115CAMKK10.38147434
116RET0.38048139
117MAP3K50.35845617
118PAK30.35452791
119PBK0.35252186
120BRD40.35186562
121ERBB20.33692358
122FYN0.32713444
123PRKCZ0.32619999
124DYRK1B0.32153421
125MAP2K60.32043333
126IGF1R0.31660916
127SGK20.30658316
128RPS6KL10.30457171
129RPS6KC10.30457171
130SGK10.28816997
131PRKCH0.28556249
132ZAK0.28471759
133CDK80.28251797
134HIPK20.23204771
135INSRR0.22066716
136INSR0.21511426
137MAPK30.21168017

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.01604949
2Leishmaniasis_Homo sapiens_hsa051402.90318508
3Graft-versus-host disease_Homo sapiens_hsa053322.84445605
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.74953251
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.58252235
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58237800
7Hematopoietic cell lineage_Homo sapiens_hsa046402.35527804
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22816895
9Measles_Homo sapiens_hsa051622.22521068
10Osteoclast differentiation_Homo sapiens_hsa043802.18430222
11Allograft rejection_Homo sapiens_hsa053302.17848935
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08681141
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06789810
14Asthma_Homo sapiens_hsa053102.02111310
15B cell receptor signaling pathway_Homo sapiens_hsa046621.93427116
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83858447
17Tuberculosis_Homo sapiens_hsa051521.77616574
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75756823
19T cell receptor signaling pathway_Homo sapiens_hsa046601.74405976
20Staphylococcus aureus infection_Homo sapiens_hsa051501.72021719
21Antigen processing and presentation_Homo sapiens_hsa046121.67981410
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.67800076
23Legionellosis_Homo sapiens_hsa051341.66202572
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66064093
25Malaria_Homo sapiens_hsa051441.62632334
26Rheumatoid arthritis_Homo sapiens_hsa053231.62298833
27Autoimmune thyroid disease_Homo sapiens_hsa053201.53633360
28Pertussis_Homo sapiens_hsa051331.53479158
29Other glycan degradation_Homo sapiens_hsa005111.51921308
30TNF signaling pathway_Homo sapiens_hsa046681.43685152
31Toxoplasmosis_Homo sapiens_hsa051451.41628367
32Herpes simplex infection_Homo sapiens_hsa051681.41398421
33Influenza A_Homo sapiens_hsa051641.40221228
34Chemokine signaling pathway_Homo sapiens_hsa040621.36312853
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.31299567
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30818832
37Lysosome_Homo sapiens_hsa041421.26890178
38Apoptosis_Homo sapiens_hsa042101.26258240
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25960273
40Shigellosis_Homo sapiens_hsa051311.17293087
41Hepatitis B_Homo sapiens_hsa051611.16517474
42Dorso-ventral axis formation_Homo sapiens_hsa043201.15936337
43Phagosome_Homo sapiens_hsa041451.13163772
44Salmonella infection_Homo sapiens_hsa051321.12773158
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10155316
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.07855311
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06691787
48Viral myocarditis_Homo sapiens_hsa054161.03994798
49Acute myeloid leukemia_Homo sapiens_hsa052211.02671972
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98853661
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95924172
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94169161
53Type I diabetes mellitus_Homo sapiens_hsa049400.92843001
54Sphingolipid metabolism_Homo sapiens_hsa006000.90582215
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88229028
56Platelet activation_Homo sapiens_hsa046110.86695264
57African trypanosomiasis_Homo sapiens_hsa051430.85675639
58Hepatitis C_Homo sapiens_hsa051600.83286266
59Renal cell carcinoma_Homo sapiens_hsa052110.83085430
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81417702
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80277905
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77745514
63Pancreatic cancer_Homo sapiens_hsa052120.73448887
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64056395
65Endometrial cancer_Homo sapiens_hsa052130.63835205
66Protein export_Homo sapiens_hsa030600.62634326
67GnRH signaling pathway_Homo sapiens_hsa049120.61897152
68Prolactin signaling pathway_Homo sapiens_hsa049170.61098294
69HTLV-I infection_Homo sapiens_hsa051660.60691097
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60575533
71Epstein-Barr virus infection_Homo sapiens_hsa051690.60509196
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60121421
73Choline metabolism in cancer_Homo sapiens_hsa052310.59503599
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58963548
75Chronic myeloid leukemia_Homo sapiens_hsa052200.58649987
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.55583484
77mTOR signaling pathway_Homo sapiens_hsa041500.54662105
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.53932003
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53548898
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52592462
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.52226145
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.50449030
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49989942
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.48778075
85Insulin resistance_Homo sapiens_hsa049310.48575647
86ErbB signaling pathway_Homo sapiens_hsa040120.48445328
87p53 signaling pathway_Homo sapiens_hsa041150.47478390
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46604908
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45062031
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44592894
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44182689
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42890856
93Glioma_Homo sapiens_hsa052140.41803999
94VEGF signaling pathway_Homo sapiens_hsa043700.39913488
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37994024
96Notch signaling pathway_Homo sapiens_hsa043300.36672026
97Type II diabetes mellitus_Homo sapiens_hsa049300.36374897
98Amoebiasis_Homo sapiens_hsa051460.35130215
99Viral carcinogenesis_Homo sapiens_hsa052030.33963211
100FoxO signaling pathway_Homo sapiens_hsa040680.33884525
101Small cell lung cancer_Homo sapiens_hsa052220.32471442
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30495229
103Arachidonic acid metabolism_Homo sapiens_hsa005900.27694286
104Caffeine metabolism_Homo sapiens_hsa002320.27233623
105Collecting duct acid secretion_Homo sapiens_hsa049660.26920305
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26879150
107HIF-1 signaling pathway_Homo sapiens_hsa040660.26013677
108Inositol phosphate metabolism_Homo sapiens_hsa005620.25945723
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24999775
110Adherens junction_Homo sapiens_hsa045200.24364234
111Regulation of autophagy_Homo sapiens_hsa041400.24335639
112Non-small cell lung cancer_Homo sapiens_hsa052230.23558010
113Prostate cancer_Homo sapiens_hsa052150.23119478
114MicroRNAs in cancer_Homo sapiens_hsa052060.22454142
115MAPK signaling pathway_Homo sapiens_hsa040100.21833661
116Proteoglycans in cancer_Homo sapiens_hsa052050.21416872
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21218831
118Rap1 signaling pathway_Homo sapiens_hsa040150.20362143
119Colorectal cancer_Homo sapiens_hsa052100.20106302
120Endocytosis_Homo sapiens_hsa041440.20097944

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