TMEM155

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)9.79932423
2synaptic vesicle maturation (GO:0016188)9.02180406
3glutamate secretion (GO:0014047)8.44944280
4regulation of short-term neuronal synaptic plasticity (GO:0048172)7.60916357
5synaptic vesicle exocytosis (GO:0016079)7.24328894
6regulation of synaptic vesicle exocytosis (GO:2000300)7.07232768
7regulation of synaptic vesicle transport (GO:1902803)6.14927732
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.88593781
9cellular potassium ion homeostasis (GO:0030007)5.84605253
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.84208218
11neurotransmitter secretion (GO:0007269)5.55982884
12regulation of neuronal synaptic plasticity (GO:0048168)5.44754526
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41164501
14sodium ion export (GO:0071436)5.28835662
15locomotory exploration behavior (GO:0035641)5.23113256
16L-amino acid import (GO:0043092)5.06538615
17negative regulation of dendrite morphogenesis (GO:0050774)4.96912826
18neuronal action potential propagation (GO:0019227)4.89497078
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.84184638
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.70646437
21exploration behavior (GO:0035640)4.69038195
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.55075065
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.49885343
24cerebellar granule cell differentiation (GO:0021707)4.47551449
25amino acid import (GO:0043090)4.45920092
26neurotransmitter transport (GO:0006836)4.43020312
27positive regulation of synapse maturation (GO:0090129)4.39917153
28regulation of neurotransmitter secretion (GO:0046928)4.36270707
29negative regulation of synaptic transmission, GABAergic (GO:0032229)4.33245826
30synaptic transmission, glutamatergic (GO:0035249)4.30637238
31regulation of synaptic plasticity (GO:0048167)4.28727405
32protein localization to synapse (GO:0035418)4.27974781
33vocalization behavior (GO:0071625)4.23413769
34positive regulation of neurotransmitter secretion (GO:0001956)4.22651426
35regulation of glutamate receptor signaling pathway (GO:1900449)4.15837969
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09985535
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.08642882
38regulation of excitatory postsynaptic membrane potential (GO:0060079)4.07165285
39regulation of voltage-gated calcium channel activity (GO:1901385)4.06634623
40neuron-neuron synaptic transmission (GO:0007270)4.06571410
41positive regulation of neurotransmitter transport (GO:0051590)4.05683775
42positive regulation of membrane potential (GO:0045838)3.98535636
43synaptic vesicle endocytosis (GO:0048488)3.97594102
44positive regulation of dendritic spine development (GO:0060999)3.97495134
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.96086853
46regulation of neurotransmitter transport (GO:0051588)3.89685995
47regulation of synapse structural plasticity (GO:0051823)3.89436102
48neuromuscular process controlling balance (GO:0050885)3.89107216
49regulation of neurotransmitter levels (GO:0001505)3.85408774
50neuronal ion channel clustering (GO:0045161)3.83744767
51regulation of dendritic spine morphogenesis (GO:0061001)3.83291141
52potassium ion homeostasis (GO:0055075)3.82936022
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.82519379
54regulation of ARF protein signal transduction (GO:0032012)3.78235331
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.76405097
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.75043984
57long-term memory (GO:0007616)3.71749158
58regulation of postsynaptic membrane potential (GO:0060078)3.70205074
59layer formation in cerebral cortex (GO:0021819)3.69767795
60cerebellar Purkinje cell differentiation (GO:0021702)3.69248328
61glutamate receptor signaling pathway (GO:0007215)3.63976379
62cell communication by electrical coupling (GO:0010644)3.63049207
63vesicle docking involved in exocytosis (GO:0006904)3.59868668
64regulation of vesicle fusion (GO:0031338)3.59273608
65regulation of dendritic spine development (GO:0060998)3.54280997
66potassium ion import (GO:0010107)3.54145176
67neurotransmitter-gated ion channel clustering (GO:0072578)3.54044457
68dendritic spine morphogenesis (GO:0060997)3.53330320
69neuromuscular process controlling posture (GO:0050884)3.47461107
70activation of protein kinase A activity (GO:0034199)3.46971827
71vesicle docking (GO:0048278)3.40006995
72gamma-aminobutyric acid transport (GO:0015812)3.38065957
73regulation of synapse maturation (GO:0090128)3.37989222
74regulation of synaptic transmission (GO:0050804)3.35367475
75proline transport (GO:0015824)3.35290482
76membrane depolarization during action potential (GO:0086010)3.34942380
77membrane depolarization (GO:0051899)3.32916408
78acidic amino acid transport (GO:0015800)3.31387186
79long-term synaptic potentiation (GO:0060291)3.29737645
80central nervous system myelination (GO:0022010)3.27230005
81axon ensheathment in central nervous system (GO:0032291)3.27230005
82detection of calcium ion (GO:0005513)3.27189931
83response to gravity (GO:0009629)3.25839929
84cellular sodium ion homeostasis (GO:0006883)3.21043583
85synaptic transmission (GO:0007268)3.20366233
86cytoskeletal anchoring at plasma membrane (GO:0007016)3.19728193
87postsynaptic membrane organization (GO:0001941)3.18903693
88neuron cell-cell adhesion (GO:0007158)3.17919974
89dendritic spine organization (GO:0097061)3.15716391
90establishment of synaptic vesicle localization (GO:0097480)3.14981511
91synaptic vesicle transport (GO:0048489)3.14981511
92neuromuscular process (GO:0050905)3.10574214
93dicarboxylic acid transport (GO:0006835)3.07242954
94acid secretion (GO:0046717)3.06652467
95serotonin metabolic process (GO:0042428)3.06538023
96regulation of exocytosis (GO:0017157)3.06412474
97neurotransmitter uptake (GO:0001504)3.05983428
98phosphorelay signal transduction system (GO:0000160)3.05383917
99regulation of dendrite morphogenesis (GO:0048814)2.99211869
100positive regulation of dendrite development (GO:1900006)2.97957455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.70726089
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.52004930
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.42945252
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.33375136
5RARB_27405468_Chip-Seq_BRAIN_Mouse3.31783693
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21317448
7REST_21632747_ChIP-Seq_MESCs_Mouse3.20776043
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.97474624
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.95998333
10DROSHA_22980978_ChIP-Seq_HELA_Human2.95318888
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.93264238
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.93264238
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.92755397
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.74724943
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.74252290
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.73369305
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72752475
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.70240334
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.64727223
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.64127166
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.61762319
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54028576
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.50353759
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.47675750
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.45433886
26GBX2_23144817_ChIP-Seq_PC3_Human2.45292576
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38909994
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97167541
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86338271
30RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.85078039
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.74319019
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71814387
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64323822
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.61866910
35KDM2B_26808549_Chip-Seq_K562_Human1.59937563
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54950790
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49979687
38TET1_21490601_ChIP-Seq_MESCs_Mouse1.43561442
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42906052
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41900998
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41654652
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.40728299
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39571883
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34332048
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30520540
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26563993
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26189728
48AR_21572438_ChIP-Seq_LNCaP_Human1.26097316
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23203694
50CTCF_27219007_Chip-Seq_Bcells_Human1.19771843
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.18338694
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16352985
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.11455357
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09815048
55AR_19668381_ChIP-Seq_PC3_Human1.08958663
56RNF2_27304074_Chip-Seq_NSC_Mouse1.03701531
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00132696
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99495090
59GATA1_26923725_Chip-Seq_HPCs_Mouse0.98681086
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97117296
61ESR2_21235772_ChIP-Seq_MCF-7_Human0.96480832
62KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95310555
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94960488
64SOX2_21211035_ChIP-Seq_LN229_Gbm0.94481269
65* SMAD4_21799915_ChIP-Seq_A2780_Human0.94243035
66DPY_21335234_ChIP-Seq_ESCs_Mouse0.94183674
67CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93344262
68LXR_22292898_ChIP-Seq_THP-1_Human0.92470514
69EGR1_19032775_ChIP-ChIP_M12_Human0.92329973
70YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92251851
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91761504
72CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90723371
73SMAD_19615063_ChIP-ChIP_OVARY_Human0.90478353
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88316170
75TP53_20018659_ChIP-ChIP_R1E_Mouse0.87084094
76CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86209539
77P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86111427
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86035055
79CBX2_27304074_Chip-Seq_ESCs_Mouse0.85883724
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85793233
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85610756
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83743180
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81605291
84ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80502857
85KLF4_19829295_ChIP-Seq_ESCs_Human0.79695117
86OCT4_19829295_ChIP-Seq_ESCs_Human0.79429511
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79125017
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77755794
89RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76967489
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76958779
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76793133
92TP53_23651856_ChIP-Seq_MEFs_Mouse0.75998173
93SMAD3_21741376_ChIP-Seq_EPCs_Human0.75091135
94EP300_21415370_ChIP-Seq_HL-1_Mouse0.74979065
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73250722
96MYC_19915707_ChIP-ChIP_AK7_Human0.73038849
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72288832
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71287585
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70732837
100SMC4_20622854_ChIP-Seq_HELA_Human0.70322118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.44353751
2MP0003880_abnormal_central_pattern5.70236003
3MP0004270_analgesia4.67926635
4MP0003635_abnormal_synaptic_transmissio4.28611834
5MP0002064_seizures3.92802904
6MP0009745_abnormal_behavioral_response3.55412106
7MP0002063_abnormal_learning/memory/cond3.42419628
8MP0005423_abnormal_somatic_nervous3.33518920
9MP0009046_muscle_twitch3.26323596
10MP0002272_abnormal_nervous_system3.14387733
11MP0001486_abnormal_startle_reflex3.08852792
12MP0001968_abnormal_touch/_nociception2.98250640
13MP0002734_abnormal_mechanical_nocicepti2.93346237
14MP0002572_abnormal_emotion/affect_behav2.84969370
15MP0001501_abnormal_sleep_pattern2.67925991
16MP0003329_amyloid_beta_deposits2.52989079
17MP0008569_lethality_at_weaning2.34950793
18MP0003879_abnormal_hair_cell2.30558057
19MP0002735_abnormal_chemical_nociception2.19427088
20MP0002736_abnormal_nociception_after2.12167938
21MP0001970_abnormal_pain_threshold1.93605740
22MP0003787_abnormal_imprinting1.85220688
23MP0004811_abnormal_neuron_physiology1.76169415
24MP0002733_abnormal_thermal_nociception1.73910618
25MP0002067_abnormal_sensory_capabilities1.72370135
26MP0009780_abnormal_chondrocyte_physiolo1.72065083
27MP0001440_abnormal_grooming_behavior1.67356069
28MP0003633_abnormal_nervous_system1.67177363
29MP0003690_abnormal_glial_cell1.57149304
30MP0000920_abnormal_myelination1.55366284
31MP0002557_abnormal_social/conspecific_i1.48689740
32MP0002066_abnormal_motor_capabilities/c1.48553564
33MP0005646_abnormal_pituitary_gland1.44281719
34MP0004924_abnormal_behavior1.41030910
35MP0005386_behavior/neurological_phenoty1.41030910
36MP0001177_atelectasis1.39298981
37MP0000778_abnormal_nervous_system1.38926805
38MP0003631_nervous_system_phenotype1.36839457
39MP0003123_paternal_imprinting1.35063552
40MP0002882_abnormal_neuron_morphology1.32588212
41MP0001905_abnormal_dopamine_level1.31118439
42MP0000604_amyloidosis1.24875057
43MP0000955_abnormal_spinal_cord1.24466102
44MP0001502_abnormal_circadian_rhythm1.23723796
45MP0004885_abnormal_endolymph1.19502488
46MP0006276_abnormal_autonomic_nervous1.18399550
47MP0005623_abnormal_meninges_morphology1.18059754
48MP0003122_maternal_imprinting1.12846882
49MP0002184_abnormal_innervation1.11599258
50MP0008877_abnormal_DNA_methylation1.09446272
51MP0010386_abnormal_urinary_bladder1.07786429
52MP0004742_abnormal_vestibular_system1.01546816
53MP0003634_abnormal_glial_cell1.01265923
54MP0003075_altered_response_to0.99673319
55MP0001963_abnormal_hearing_physiology0.98594419
56MP0002638_abnormal_pupillary_reflex0.97236890
57MP0002229_neurodegeneration0.97100668
58MP0008874_decreased_physiological_sensi0.96994983
59MP0001984_abnormal_olfaction0.96711937
60MP0002152_abnormal_brain_morphology0.95016469
61MP0004147_increased_porphyrin_level0.91863209
62MP0001348_abnormal_lacrimal_gland0.87982919
63MP0001346_abnormal_lacrimal_gland0.83792029
64MP0003632_abnormal_nervous_system0.83100416
65MP0003172_abnormal_lysosome_physiology0.82832008
66MP0002822_catalepsy0.80623241
67MP0001958_emphysema0.70843827
68MP0005551_abnormal_eye_electrophysiolog0.68792492
69MP0000751_myopathy0.66686283
70MP0005535_abnormal_body_temperature0.65857820
71MP0001299_abnormal_eye_distance/0.64943794
72MP0002069_abnormal_eating/drinking_beha0.62557649
73MP0001485_abnormal_pinna_reflex0.61758563
74MP0003137_abnormal_impulse_conducting0.60728029
75MP0004130_abnormal_muscle_cell0.55220988
76MP0002752_abnormal_somatic_nervous0.53140562
77MP0001943_abnormal_respiration0.52481653
78MP0003283_abnormal_digestive_organ0.51729075
79MP0004085_abnormal_heartbeat0.51697953
80MP0005257_abnormal_intraocular_pressure0.51475597
81MP0010769_abnormal_survival0.50324427
82MP0005499_abnormal_olfactory_system0.48937011
83MP0005394_taste/olfaction_phenotype0.48937011
84MP0001986_abnormal_taste_sensitivity0.48411758
85MP0003956_abnormal_body_size0.47880146
86MP0002089_abnormal_postnatal_growth/wei0.47798467
87MP0010768_mortality/aging0.47422750
88MP0004510_myositis0.46452671
89MP0003121_genomic_imprinting0.46378438
90MP0003183_abnormal_peptide_metabolism0.45822261
91MP0001529_abnormal_vocalization0.45360170
92MP0010770_preweaning_lethality0.45267298
93MP0002082_postnatal_lethality0.45267298
94MP0008872_abnormal_physiological_respon0.44774953
95MP0005388_respiratory_system_phenotype0.44141468
96MP0002133_abnormal_respiratory_system0.44141468
97MP0005166_decreased_susceptibility_to0.42627039
98MP0003705_abnormal_hypodermis_morpholog0.41393662
99MP0002873_normal_phenotype0.39783190
100MP0002090_abnormal_vision0.38810540

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.56237300
2Focal motor seizures (HP:0011153)8.17100807
3Focal seizures (HP:0007359)6.61705124
4Febrile seizures (HP:0002373)6.14882641
5Atonic seizures (HP:0010819)5.92341601
6Action tremor (HP:0002345)5.56151044
7Epileptic encephalopathy (HP:0200134)5.30206129
8Supranuclear gaze palsy (HP:0000605)5.18290638
9Diplopia (HP:0000651)5.01886150
10Abnormality of binocular vision (HP:0011514)5.01886150
11Ankle clonus (HP:0011448)4.61354781
12Generalized tonic-clonic seizures (HP:0002069)4.22873300
13Papilledema (HP:0001085)4.05508366
14Absence seizures (HP:0002121)4.00506241
15Neurofibrillary tangles (HP:0002185)3.98829811
16Visual hallucinations (HP:0002367)3.94597277
17Torticollis (HP:0000473)3.85390145
18Spastic gait (HP:0002064)3.85278314
19Impaired vibration sensation in the lower limbs (HP:0002166)3.79387334
20Dialeptic seizures (HP:0011146)3.78299303
21Obstructive sleep apnea (HP:0002870)3.75702457
22Dysmetria (HP:0001310)3.57989471
23Annular pancreas (HP:0001734)3.56819528
24Progressive cerebellar ataxia (HP:0002073)3.49742550
25Tetraplegia (HP:0002445)3.47248241
26Abnormal eating behavior (HP:0100738)3.41884206
27Postural instability (HP:0002172)3.41136766
28Mutism (HP:0002300)3.34280970
29Urinary bladder sphincter dysfunction (HP:0002839)3.33290806
30Neuronal loss in central nervous system (HP:0002529)3.30226924
31Truncal ataxia (HP:0002078)3.28400640
32Cerebral inclusion bodies (HP:0100314)3.28221523
33Focal dystonia (HP:0004373)3.23752645
34Intention tremor (HP:0002080)3.20926442
35Delusions (HP:0000746)3.12140300
36Depression (HP:0000716)3.00806815
37Cerebral hypomyelination (HP:0006808)2.98877914
38Craniofacial dystonia (HP:0012179)2.98329129
39Urinary urgency (HP:0000012)2.96494485
40Status epilepticus (HP:0002133)2.95579838
41Amblyopia (HP:0000646)2.89186442
42Lower limb muscle weakness (HP:0007340)2.86695759
43Poor eye contact (HP:0000817)2.85707940
44Bradykinesia (HP:0002067)2.82629804
45Epileptiform EEG discharges (HP:0011182)2.79187602
46Hemiplegia (HP:0002301)2.77358490
47Anxiety (HP:0000739)2.73230267
48Limb dystonia (HP:0002451)2.67683220
49Clonus (HP:0002169)2.65548435
50Abnormality of the lower motor neuron (HP:0002366)2.62970241
51Akinesia (HP:0002304)2.57378588
52Impaired vibratory sensation (HP:0002495)2.56023080
53Scanning speech (HP:0002168)2.55360029
54Insomnia (HP:0100785)2.47505937
55Abnormality of the corticospinal tract (HP:0002492)2.46921577
56Apathy (HP:0000741)2.41306860
57Dysdiadochokinesis (HP:0002075)2.40560044
58Sleep apnea (HP:0010535)2.38740305
59Impaired smooth pursuit (HP:0007772)2.34029122
60EEG with generalized epileptiform discharges (HP:0011198)2.32439033
61Bundle branch block (HP:0011710)2.25760196
62Abnormal social behavior (HP:0012433)2.24737332
63Impaired social interactions (HP:0000735)2.24737332
64Rigidity (HP:0002063)2.23319106
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.19295529
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19295529
67Incomplete penetrance (HP:0003829)2.18738099
68Hemiparesis (HP:0001269)2.15423746
69Abnormality of ocular smooth pursuit (HP:0000617)2.12429279
70Slow saccadic eye movements (HP:0000514)2.12182419
71Diminished motivation (HP:0000745)2.07775991
72Hypsarrhythmia (HP:0002521)2.07767774
73Stereotypic behavior (HP:0000733)2.07532039
74Abnormality of saccadic eye movements (HP:0000570)2.05522359
75Spastic tetraparesis (HP:0001285)2.03051500
76Lower limb amyotrophy (HP:0007210)2.02794345
77Rapidly progressive (HP:0003678)2.00581511
78Peripheral hypomyelination (HP:0007182)1.99860832
79Spinal canal stenosis (HP:0003416)1.98762223
80Choreoathetosis (HP:0001266)1.98512326
81Upper limb amyotrophy (HP:0009129)1.93636671
82Distal upper limb amyotrophy (HP:0007149)1.93636671
83Mild short stature (HP:0003502)1.92825498
84Lower limb asymmetry (HP:0100559)1.91322223
85Gaze-evoked nystagmus (HP:0000640)1.89104838
86Hand muscle atrophy (HP:0009130)1.88016386
87Heart block (HP:0012722)1.85423698
88Memory impairment (HP:0002354)1.83686912
89Abnormal atrioventricular conduction (HP:0005150)1.78821558
90Aplasia involving bones of the extremities (HP:0009825)1.78552654
91Aplasia involving bones of the upper limbs (HP:0009823)1.78552654
92Aplasia of the phalanges of the hand (HP:0009802)1.78552654
93CNS hypomyelination (HP:0003429)1.78075738
94Gait ataxia (HP:0002066)1.77998259
95Ventricular fibrillation (HP:0001663)1.75733430
96Morphological abnormality of the pyramidal tract (HP:0002062)1.73421063
97Bronchomalacia (HP:0002780)1.71016264
98Absent speech (HP:0001344)1.70836854
99Drooling (HP:0002307)1.68967127
100Dysmetric saccades (HP:0000641)1.68183154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.95324201
2PAK64.06312668
3DAPK24.01562978
4NTRK33.85837091
5MAP3K92.73714999
6MARK12.65214318
7NTRK12.61893542
8UHMK12.45700791
9CAMKK12.36631399
10MINK12.19125042
11PRKD32.14925346
12CDK192.06566804
13RIPK42.05004508
14LATS22.02449789
15NTRK22.00208701
16PLK21.97314817
17ARAF1.96728051
18GRK51.84736041
19DAPK11.76398354
20KSR21.55064864
21MAP3K131.53349115
22CDK51.52034767
23CAMK11.50297753
24MAPK131.38168832
25CASK1.28024293
26PINK11.26307309
27PRKCH1.22343002
28PRKCG1.19343547
29BMPR21.17002354
30CDK151.14336244
31CDK181.10728568
32STK381.05634093
33CDK11A1.05476131
34CAMK2B1.04917480
35DYRK1A1.00032378
36CDK140.99256823
37CAMKK20.98898958
38TYRO30.98114883
39PRPF4B0.96707067
40PTK2B0.95206956
41RIPK10.93826526
42MARK20.92237453
43OXSR10.91931052
44CAMK2A0.91110705
45PAK30.90962862
46SGK2230.89978574
47SGK4940.89978574
48NEK60.89789706
49BRSK10.86396818
50MAPK120.86251550
51ALK0.85354153
52SIK20.84726628
53STK110.82752914
54PDK10.77039734
55BRAF0.76405579
56MAP3K110.76033300
57DAPK30.75023987
58PHKG20.71165064
59PHKG10.71165064
60MAP2K40.70589884
61PNCK0.69730566
62PDPK10.67288589
63CAMK2G0.66666835
64CAMK40.66061033
65SGK10.66012342
66LIMK10.65340135
67MAP3K120.64873084
68PRKG20.60070979
69TESK10.59346492
70SGK20.58839663
71SGK30.58037554
72MAPK100.56833362
73RAF10.56363248
74MOS0.56028042
75KSR10.55564796
76MAP3K40.53213212
77PDGFRA0.50021185
78SCYL20.48930914
79RPS6KA30.48721088
80MAP3K10.45228293
81CAMK1G0.44332655
82PKN10.42761621
83WNK10.42634608
84CCNB10.42264091
85ROCK20.40542925
86FES0.39778273
87PRKCZ0.39575819
88FYN0.37616457
89CAMK2D0.36929211
90MAP2K70.36517476
91ROCK10.32380135
92RET0.32258487
93JAK10.32209246
94PRKCA0.31625340
95MAP3K20.30954784
96MAP2K10.30423052
97FGFR20.29778705
98MAP2K60.27845453
99CSNK1G20.26978024
100MAPK70.26946512

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.19379182
2Nicotine addiction_Homo sapiens_hsa050334.14713851
3Long-term potentiation_Homo sapiens_hsa047203.13503049
4Amphetamine addiction_Homo sapiens_hsa050312.96447911
5Circadian entrainment_Homo sapiens_hsa047132.71211230
6GABAergic synapse_Homo sapiens_hsa047272.69768442
7Morphine addiction_Homo sapiens_hsa050322.55038504
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53463652
9Glutamatergic synapse_Homo sapiens_hsa047242.52488803
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.50603659
11Insulin secretion_Homo sapiens_hsa049112.49725180
12Gastric acid secretion_Homo sapiens_hsa049712.16515885
13Dopaminergic synapse_Homo sapiens_hsa047282.15566160
14Vitamin B6 metabolism_Homo sapiens_hsa007502.12046253
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.04564802
16Cocaine addiction_Homo sapiens_hsa050302.02872509
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93311542
18Salivary secretion_Homo sapiens_hsa049701.87475925
19Cholinergic synapse_Homo sapiens_hsa047251.80260708
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.73703369
21Oxytocin signaling pathway_Homo sapiens_hsa049211.68696492
22Calcium signaling pathway_Homo sapiens_hsa040201.65828850
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61515440
24Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.53598756
25Renin secretion_Homo sapiens_hsa049241.50440788
26cAMP signaling pathway_Homo sapiens_hsa040241.45838763
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39133821
28Glioma_Homo sapiens_hsa052141.35297002
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35015265
30GnRH signaling pathway_Homo sapiens_hsa049121.34412770
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27289818
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22789490
33Melanogenesis_Homo sapiens_hsa049161.20144662
34Taste transduction_Homo sapiens_hsa047421.18642724
35Long-term depression_Homo sapiens_hsa047301.18574618
36Estrogen signaling pathway_Homo sapiens_hsa049151.15591420
37Collecting duct acid secretion_Homo sapiens_hsa049661.15014229
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13954883
39Gap junction_Homo sapiens_hsa045401.11712200
40Olfactory transduction_Homo sapiens_hsa047401.11359899
41Oocyte meiosis_Homo sapiens_hsa041141.11160479
42Serotonergic synapse_Homo sapiens_hsa047261.02494277
43Pancreatic secretion_Homo sapiens_hsa049721.00600046
44ErbB signaling pathway_Homo sapiens_hsa040120.91518238
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.91470059
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84301940
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83912956
48Thyroid hormone synthesis_Homo sapiens_hsa049180.81516376
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.79546723
50Vibrio cholerae infection_Homo sapiens_hsa051100.79144209
51Cardiac muscle contraction_Homo sapiens_hsa042600.78300419
52Rap1 signaling pathway_Homo sapiens_hsa040150.74873191
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.74757107
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74733912
55Type II diabetes mellitus_Homo sapiens_hsa049300.72729282
56Axon guidance_Homo sapiens_hsa043600.71580538
57VEGF signaling pathway_Homo sapiens_hsa043700.71330986
58MAPK signaling pathway_Homo sapiens_hsa040100.70602856
59Ras signaling pathway_Homo sapiens_hsa040140.70047827
60Inositol phosphate metabolism_Homo sapiens_hsa005620.68987406
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68245596
62Dilated cardiomyopathy_Homo sapiens_hsa054140.66918613
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66534891
64Prion diseases_Homo sapiens_hsa050200.66274951
65Bile secretion_Homo sapiens_hsa049760.63413787
66Glucagon signaling pathway_Homo sapiens_hsa049220.62099580
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62029532
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.61880351
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60241429
70Phototransduction_Homo sapiens_hsa047440.58338117
71Endocytosis_Homo sapiens_hsa041440.57942208
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56473387
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54846024
74Choline metabolism in cancer_Homo sapiens_hsa052310.50255815
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49015597
76mTOR signaling pathway_Homo sapiens_hsa041500.45255761
77Wnt signaling pathway_Homo sapiens_hsa043100.40887776
78Dorso-ventral axis formation_Homo sapiens_hsa043200.38579016
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35087599
80Arginine biosynthesis_Homo sapiens_hsa002200.34701416
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34243476
82Alcoholism_Homo sapiens_hsa050340.33828128
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32933385
84Arginine and proline metabolism_Homo sapiens_hsa003300.30111735
85Circadian rhythm_Homo sapiens_hsa047100.29997519
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29696470
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27668920
88Insulin signaling pathway_Homo sapiens_hsa049100.27551102
89Hippo signaling pathway_Homo sapiens_hsa043900.26385729
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25753223
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22340972
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21813145
93Tight junction_Homo sapiens_hsa045300.21153290
94Mineral absorption_Homo sapiens_hsa049780.19319492
95Alzheimers disease_Homo sapiens_hsa050100.18813819
96AMPK signaling pathway_Homo sapiens_hsa041520.18494066
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17475369
98HIF-1 signaling pathway_Homo sapiens_hsa040660.17296850
99Focal adhesion_Homo sapiens_hsa045100.17240787
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16419081

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