TMEM158

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.89801578
2synaptic vesicle maturation (GO:0016188)5.61235631
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.45418246
4protein heterotrimerization (GO:0070208)5.39749096
5regulation of synapse structural plasticity (GO:0051823)5.39129804
6locomotory exploration behavior (GO:0035641)5.37725910
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.32509926
8vocalization behavior (GO:0071625)5.30272882
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08233044
10skin morphogenesis (GO:0043589)4.90725810
11regulation of long-term neuronal synaptic plasticity (GO:0048169)4.89525524
12synaptic vesicle exocytosis (GO:0016079)4.85845458
13mesodermal cell differentiation (GO:0048333)4.77266650
14regulation of glutamate receptor signaling pathway (GO:1900449)4.74245366
15protein localization to synapse (GO:0035418)4.73956324
16chondrocyte proliferation (GO:0035988)4.73934325
17endodermal cell differentiation (GO:0035987)4.73114258
18positive regulation of synaptic transmission, GABAergic (GO:0032230)4.58639561
19regulation of neuronal synaptic plasticity (GO:0048168)4.58298208
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.55996464
21exploration behavior (GO:0035640)4.51127421
22layer formation in cerebral cortex (GO:0021819)4.49658535
23regulation of synaptic vesicle exocytosis (GO:2000300)4.45905171
24prepulse inhibition (GO:0060134)4.42971918
25substrate-dependent cell migration (GO:0006929)4.21002244
26synaptic transmission, dopaminergic (GO:0001963)4.19692592
27dendritic spine morphogenesis (GO:0060997)4.19048748
28glutamate secretion (GO:0014047)4.19046590
29neuron cell-cell adhesion (GO:0007158)4.16384503
30lung vasculature development (GO:0060426)4.13918012
31kidney mesenchyme development (GO:0072074)4.12634415
32mesenchymal-epithelial cell signaling (GO:0060638)4.12440798
33neurotransmitter secretion (GO:0007269)4.11007323
34adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.10016216
35neurotransmitter-gated ion channel clustering (GO:0072578)4.04918556
36regulation of dendritic spine morphogenesis (GO:0061001)4.03792417
37bone trabecula formation (GO:0060346)4.03637380
38glutamate receptor signaling pathway (GO:0007215)4.02735261
39dopamine receptor signaling pathway (GO:0007212)4.00369395
40cell adhesion mediated by integrin (GO:0033627)3.99296920
41regulation of synaptic vesicle transport (GO:1902803)3.98326597
42G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.97769393
43synaptic vesicle docking involved in exocytosis (GO:0016081)3.96997829
44synaptic transmission, glutamatergic (GO:0035249)3.92295892
45protein retention in ER lumen (GO:0006621)3.92036928
46regulation of glutamate secretion (GO:0014048)3.91957062
47positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.91755893
48neuronal action potential propagation (GO:0019227)3.91683567
49neuron-neuron synaptic transmission (GO:0007270)3.90533841
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.89271892
51cellular response to vitamin D (GO:0071305)3.86709606
52auditory behavior (GO:0031223)3.84948663
53planar cell polarity pathway involved in neural tube closure (GO:0090179)3.84360980
54cellular response to vitamin (GO:0071295)3.84067514
55neuromuscular process controlling balance (GO:0050885)3.83783662
56adhesion of symbiont to host cell (GO:0044650)3.80391503
57virion attachment to host cell (GO:0019062)3.80391503
58regulation of female receptivity (GO:0045924)3.80046741
59muscle cell migration (GO:0014812)3.79690093
60positive regulation of neurotransmitter secretion (GO:0001956)3.76950390
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.76842921
62positive regulation of neurotransmitter transport (GO:0051590)3.73633349
63proline transport (GO:0015824)3.73241428
64adenosine receptor signaling pathway (GO:0001973)3.72857504
65protein localization to endosome (GO:0036010)3.72640977
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71471909
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.69192477
68behavioral defense response (GO:0002209)3.66585736
69behavioral fear response (GO:0001662)3.66585736
70regulation of postsynaptic membrane potential (GO:0060078)3.66509436
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66236575
72regulation of early endosome to late endosome transport (GO:2000641)3.66032888
73neuron recognition (GO:0008038)3.65422354
74regulation of synaptic plasticity (GO:0048167)3.65363381
75response to amphetamine (GO:0001975)3.65169731
76transmission of nerve impulse (GO:0019226)3.64363396
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63673203
78gamma-aminobutyric acid transport (GO:0015812)3.62202784
79striatum development (GO:0021756)3.61776799
80long-term memory (GO:0007616)3.60870464
81regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.58421406
82activation of protein kinase A activity (GO:0034199)3.56519614
83neuronal ion channel clustering (GO:0045161)3.56467272
84hypotonic response (GO:0006971)3.56007892
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.53798138
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.53277608
87positive regulation of membrane potential (GO:0045838)3.52536939
88positive regulation of astrocyte differentiation (GO:0048711)3.52276905
89type B pancreatic cell proliferation (GO:0044342)3.51030389
90positive regulation of blood vessel endothelial cell migration (GO:0043536)3.50391014
91positive regulation of osteoblast proliferation (GO:0033690)3.47790263
92response to auditory stimulus (GO:0010996)3.46993892
93positive regulation of synapse maturation (GO:0090129)3.44347065
94protein maturation by protein folding (GO:0022417)3.41697745
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41473042
96female mating behavior (GO:0060180)3.39514632
97adhesion of symbiont to host (GO:0044406)3.37638655
98behavioral response to cocaine (GO:0048148)3.37358775
99peptidyl-proline hydroxylation (GO:0019511)3.36740499
100fear response (GO:0042596)3.31493325
101basement membrane organization (GO:0071711)3.30477969
102COPI coating of Golgi vesicle (GO:0048205)3.29967160
103Golgi transport vesicle coating (GO:0048200)3.29967160
104regulation of dendritic spine development (GO:0060998)3.29588768
105collagen fibril organization (GO:0030199)3.29327015
106regulation of synaptic transmission, GABAergic (GO:0032228)3.28904514
107cochlea morphogenesis (GO:0090103)3.28688262
108axonal fasciculation (GO:0007413)3.28288301
109neurotransmitter transport (GO:0006836)3.27731306
110negative regulation of dendrite development (GO:2000171)3.27519834
111long-term synaptic potentiation (GO:0060291)3.26822091
112response to histamine (GO:0034776)3.24431207
113cellular potassium ion homeostasis (GO:0030007)3.22823564
114learning (GO:0007612)3.22170810
115dendritic spine organization (GO:0097061)3.22134651
116negative regulation of amino acid transport (GO:0051956)3.21226273
117sequestering of extracellular ligand from receptor (GO:0035581)3.20352227
118collagen metabolic process (GO:0032963)3.19381082
119regulation of vesicle fusion (GO:0031338)3.16413214
120positive regulation of axon extension (GO:0045773)3.15528199
121regulation of response to osmotic stress (GO:0047484)3.15524888
122tooth mineralization (GO:0034505)3.15044490
123endothelial cell morphogenesis (GO:0001886)3.13801470
124membrane depolarization (GO:0051899)3.13552057
125vesicle transport along microtubule (GO:0047496)3.13341492
126positive regulation of dendritic spine development (GO:0060999)3.12635146
127protein hydroxylation (GO:0018126)3.12290722
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.11634139
129Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.11330978
130regulation of neurotransmitter levels (GO:0001505)3.11173357
131mating behavior (GO:0007617)3.10991556
132collagen catabolic process (GO:0030574)3.08923759
133regulation of neurotransmitter secretion (GO:0046928)3.08080273
134postsynaptic membrane organization (GO:0001941)3.07949776
135membrane depolarization during action potential (GO:0086010)3.07115085
136membrane hyperpolarization (GO:0060081)3.06806368
137positive regulation of dendritic spine morphogenesis (GO:0061003)3.05063934
138positive regulation of synaptic transmission (GO:0050806)3.05041494
139heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.03198806
140neuromuscular process (GO:0050905)3.02351068
141extracellular matrix assembly (GO:0085029)3.02346870
142response to gravity (GO:0009629)3.02090863
143synapse assembly (GO:0007416)3.00142625
144regulation of voltage-gated calcium channel activity (GO:1901385)2.99946624
145social behavior (GO:0035176)2.99419957
146intraspecies interaction between organisms (GO:0051703)2.99419957
147negative regulation of dendrite morphogenesis (GO:0050774)2.99180641
148regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.99147384
149regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.99147384
150axon extension (GO:0048675)2.95133921
151cell migration involved in sprouting angiogenesis (GO:0002042)2.94892834
152negative regulation of axon extension involved in axon guidance (GO:0048843)2.90902341
153negative regulation of smooth muscle cell migration (GO:0014912)2.88723208
154regulation of establishment of planar polarity (GO:0090175)2.88400494
155regulation of mammary gland epithelial cell proliferation (GO:0033599)2.88216544
156barbed-end actin filament capping (GO:0051016)2.87041573
157multicellular organismal macromolecule metabolic process (GO:0044259)2.86495218
158regulation of glucocorticoid metabolic process (GO:0031943)2.84297924
159negative regulation of focal adhesion assembly (GO:0051895)2.81842740
160negative regulation of cell junction assembly (GO:1901889)2.81842740
161negative regulation of adherens junction organization (GO:1903392)2.81842740
162cellular response to prostaglandin stimulus (GO:0071379)2.79376716
163dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.79321006
164multicellular organismal catabolic process (GO:0044243)2.73325591
165convergent extension (GO:0060026)2.72029423
166stress fiber assembly (GO:0043149)2.71778251
167mammary gland epithelial cell proliferation (GO:0033598)2.70211312
168vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.68811712
169UV protection (GO:0009650)2.67793706
170regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.64127640
171cell-substrate junction assembly (GO:0007044)2.63976782
172multicellular organismal metabolic process (GO:0044236)2.63475079
173regulation of gonadotropin secretion (GO:0032276)2.63028012
174regulation of integrin-mediated signaling pathway (GO:2001044)2.62909384
175lung morphogenesis (GO:0060425)2.62458361
176metanephric mesenchyme development (GO:0072075)2.61487122
177negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61286537
178extracellular fibril organization (GO:0043206)2.60049957
179decidualization (GO:0046697)2.59697366
180cortical actin cytoskeleton organization (GO:0030866)2.58698514
181endocardial cushion development (GO:0003197)2.57880492
182glial cell migration (GO:0008347)2.56244054
183positive regulation of Rho protein signal transduction (GO:0035025)2.55444464
184midgut development (GO:0007494)2.54457681
185endocytic recycling (GO:0032456)2.54360151
186neuron projection extension (GO:1990138)2.53896610
187cellular response to hepatocyte growth factor stimulus (GO:0035729)2.53170228
188response to hepatocyte growth factor (GO:0035728)2.53170228
189heterochromatin organization (GO:0070828)2.53101973
190dermatan sulfate biosynthetic process (GO:0030208)2.52683580
191endothelial cell chemotaxis (GO:0035767)2.52166385
192negative regulation of homotypic cell-cell adhesion (GO:0034111)2.52100350
193platelet aggregation (GO:0070527)2.51900216
194extracellular matrix disassembly (GO:0022617)2.51138912
195cellular response to amino acid stimulus (GO:0071230)2.50729442
196positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.50585458
197adherens junction assembly (GO:0034333)2.49481296
198hyaluronan catabolic process (GO:0030214)2.49071597
199positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.46984762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42169547
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.46529142
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.79968839
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.49512541
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.41966976
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.34567249
7* RARB_27405468_Chip-Seq_BRAIN_Mouse3.34538275
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.24431443
9JARID2_20075857_ChIP-Seq_MESCs_Mouse3.07416970
10GBX2_23144817_ChIP-Seq_PC3_Human3.06892565
11ELK3_25401928_ChIP-Seq_HUVEC_Human3.04752678
12RNF2_18974828_ChIP-Seq_MESCs_Mouse3.02282398
13EZH2_18974828_ChIP-Seq_MESCs_Mouse3.02282398
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.91740556
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.87531829
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.84621148
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.80423309
18REST_21632747_ChIP-Seq_MESCs_Mouse2.78315821
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.78064533
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.75957393
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64451667
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.63034716
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.61560623
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.59119865
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.57486973
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.53144968
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51493378
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.47781463
29DROSHA_22980978_ChIP-Seq_HELA_Human2.46411525
30WT1_19549856_ChIP-ChIP_CCG9911_Human2.41322653
31* RNF2_27304074_Chip-Seq_ESCs_Mouse2.41125638
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.33444114
33TP63_17297297_ChIP-ChIP_HaCaT_Human2.26660109
34REST_18959480_ChIP-ChIP_MESCs_Mouse2.23753035
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22621042
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21295716
37CLOCK_20551151_ChIP-Seq_293T_Human2.16747407
38LXR_22292898_ChIP-Seq_THP-1_Human2.10400933
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04795139
40P300_27058665_Chip-Seq_ZR-75-30cells_Human2.03492296
41TP53_22127205_ChIP-Seq_IMR90_Human2.03059370
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.99116034
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.98192315
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96784221
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92288713
46AR_21572438_ChIP-Seq_LNCaP_Human1.91968719
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85292292
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83874139
49ZNF263_19887448_ChIP-Seq_K562_Human1.78017537
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75967262
51BRD4_25478319_ChIP-Seq_HGPS_Human1.74337512
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73352943
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68883073
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.67728938
55* UBF1/2_26484160_Chip-Seq_HMECs_Human1.65384883
56RACK7_27058665_Chip-Seq_MCF-7_Human1.65056802
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61536490
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60361980
59ATF3_27146783_Chip-Seq_COLON_Human1.58787263
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.56905675
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56009979
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55192310
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54171507
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.54068218
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53159442
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50205441
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50142462
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.49388302
69TAF15_26573619_Chip-Seq_HEK293_Human1.48484451
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45401433
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.45189090
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44499153
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43055333
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.42922937
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42475047
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40250456
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39032302
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.35627277
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35610398
80ZNF274_21170338_ChIP-Seq_K562_Hela1.35051431
81* SMAD4_21799915_ChIP-Seq_A2780_Human1.34351587
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33343122
83KDM2B_26808549_Chip-Seq_K562_Human1.33200049
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30236684
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29990268
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29034099
87KDM2B_26808549_Chip-Seq_DND41_Human1.28691611
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.28268310
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27783848
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27747735
91* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27137732
92* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26583743
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26549627
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.26363219
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26271642
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25751755
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24637670
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23697105
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23602076
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23408804
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22435646
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21368024
103* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21142902
104SA1_22415368_ChIP-Seq_MEFs_Mouse1.19617544
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18831697
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17811185
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17551315
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.16717863
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16091521
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15240026
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.15096295
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13909677
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13839297
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13809154
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13042790
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12957509
117* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12776710
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.12357626
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11406406
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11307874
121* P300_19829295_ChIP-Seq_ESCs_Human1.11211712
122* CJUN_26792858_Chip-Seq_BT549_Human1.10245365
123NCOR1_26117541_ChIP-Seq_K562_Human1.09342408
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08975795
125AR_25329375_ChIP-Seq_VCAP_Human1.08639291
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08522954
127* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07734885
128ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07553213
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07519713
130AR_19668381_ChIP-Seq_PC3_Human1.07393050
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.06438123
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06384375
133MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05690325
134CTCF_27219007_Chip-Seq_Bcells_Human1.05396784
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04893190
136TP53_20018659_ChIP-ChIP_R1E_Mouse1.00775114
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00744808
138SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00744808
139ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00006348
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99409282
141MYC_18555785_ChIP-Seq_MESCs_Mouse0.99391722
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99296808
143SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98968697
144HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98324299
145MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97176300
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96683045
147SA1_27219007_Chip-Seq_ERYTHROID_Human0.96561406
148ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96536116
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.96456577
150TET1_21490601_ChIP-Seq_MESCs_Mouse0.96261120
151YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96059952
152* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95999908
153AHR_22903824_ChIP-Seq_MCF-7_Human0.95996731
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95834347
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95160386
156* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94907111
157STAT3_23295773_ChIP-Seq_U87_Human0.93085995
158RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91921960
159CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91661802
160RNF2_27304074_Chip-Seq_NSC_Mouse0.91312507
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.90798743
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90163199
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89123726
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88973180
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.88730213
166SMAD3_21741376_ChIP-Seq_HESCs_Human0.88345410
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.87195643
168JUN_21703547_ChIP-Seq_K562_Human0.85494101
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.84426234
170VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84119388
171RUNX2_22187159_ChIP-Seq_PCA_Human0.83163836
172OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82634365
173UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81803140
174IGF1R_20145208_ChIP-Seq_DFB_Human0.81741871
175ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81211473
176RXR_22108803_ChIP-Seq_LS180_Human0.79626034
177TP53_16413492_ChIP-PET_HCT116_Human0.79462212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.75475310
2MP0004859_abnormal_synaptic_plasticity6.46007144
3MP0002822_catalepsy4.85959038
4MP0003705_abnormal_hypodermis_morpholog4.59213738
5MP0003880_abnormal_central_pattern4.49979918
6MP0003635_abnormal_synaptic_transmissio4.21541252
7MP0004270_analgesia3.76699023
8MP0001968_abnormal_touch/_nociception3.61742530
9MP0009745_abnormal_behavioral_response3.59688746
10MP0002063_abnormal_learning/memory/cond3.58021567
11MP0005257_abnormal_intraocular_pressure3.05849129
12MP0004272_abnormal_basement_membrane3.05663611
13MP0002064_seizures2.97910870
14MP0002736_abnormal_nociception_after2.97246020
15MP0001542_abnormal_bone_strength2.90060058
16MP0003279_aneurysm2.88134835
17MP0002572_abnormal_emotion/affect_behav2.84806076
18MP0002735_abnormal_chemical_nociception2.69994244
19MP0002877_abnormal_melanocyte_morpholog2.63345730
20MP0003566_abnormal_cell_adhesion2.59476024
21MP0002734_abnormal_mechanical_nocicepti2.57683451
22MP0002272_abnormal_nervous_system2.55975105
23MP0001486_abnormal_startle_reflex2.45841324
24MP0002733_abnormal_thermal_nociception2.45087506
25MP0001501_abnormal_sleep_pattern2.43802928
26MP0009046_muscle_twitch2.43639537
27MP0005423_abnormal_somatic_nervous2.39874798
28MP0009053_abnormal_anal_canal2.36633580
29MP0001958_emphysema2.23982500
30MP0001970_abnormal_pain_threshold2.23798329
31MP0005503_abnormal_tendon_morphology2.20598896
32MP0001440_abnormal_grooming_behavior2.07411347
33MP0000534_abnormal_ureter_morphology2.02913141
34MP0002909_abnormal_adrenal_gland1.99244008
35MP0009379_abnormal_foot_pigmentation1.98094784
36MP0010030_abnormal_orbit_morphology1.96957840
37MP0001529_abnormal_vocalization1.96628606
38MP0003950_abnormal_plasma_membrane1.96195624
39MP0003091_abnormal_cell_migration1.92835566
40MP0010368_abnormal_lymphatic_system1.90078754
41MP0003329_amyloid_beta_deposits1.89918360
42MP0009384_cardiac_valve_regurgitation1.87266227
43MP0005275_abnormal_skin_tensile1.83456658
44MP0004924_abnormal_behavior1.83433916
45MP0005386_behavior/neurological_phenoty1.83433916
46MP0004858_abnormal_nervous_system1.82334228
47MP0004811_abnormal_neuron_physiology1.80831634
48MP0002184_abnormal_innervation1.78647543
49MP0002557_abnormal_social/conspecific_i1.78211981
50MP0006276_abnormal_autonomic_nervous1.75684824
51MP0003942_abnormal_urinary_system1.75418723
52MP0002067_abnormal_sensory_capabilities1.74296862
53MP0001299_abnormal_eye_distance/1.72646371
54MP0005023_abnormal_wound_healing1.64796746
55MP0001188_hyperpigmentation1.63644363
56MP0000778_abnormal_nervous_system1.63502507
57MP0008569_lethality_at_weaning1.61205019
58MP0009780_abnormal_chondrocyte_physiolo1.57164280
59MP0005508_abnormal_skeleton_morphology1.57049227
60MP0003123_paternal_imprinting1.56064029
61MP0009250_abnormal_appendicular_skeleto1.53084886
62MP0000955_abnormal_spinal_cord1.49410935
63MP0000767_abnormal_smooth_muscle1.47446104
64MP0002896_abnormal_bone_mineralization1.46887755
65MP0003879_abnormal_hair_cell1.46121076
66MP0000750_abnormal_muscle_regeneration1.45209503
67MP0001984_abnormal_olfaction1.40271850
68MP0003385_abnormal_body_wall1.36212868
69MP0005646_abnormal_pituitary_gland1.35898424
70MP0002060_abnormal_skin_morphology1.35777780
71MP0005409_darkened_coat_color1.35114728
72MP0002066_abnormal_motor_capabilities/c1.34775596
73MP0000733_abnormal_muscle_development1.34724964
74MP0001905_abnormal_dopamine_level1.34251901
75MP0010234_abnormal_vibrissa_follicle1.32180967
76MP0002882_abnormal_neuron_morphology1.30048871
77MP0009840_abnormal_foam_cell1.29316578
78MP0006054_spinal_hemorrhage1.28376902
79MP0001849_ear_inflammation1.25698322
80MP0000343_altered_response_to1.25408762
81MP0004885_abnormal_endolymph1.23177960
82MP0008872_abnormal_physiological_respon1.19682594
83MP0003633_abnormal_nervous_system1.19523084
84MP0000858_altered_metastatic_potential1.18029340
85MP0005595_abnormal_vascular_smooth1.16951209
86MP0002295_abnormal_pulmonary_circulatio1.14694551
87MP0008874_decreased_physiological_sensi1.14098346
88MP0005197_abnormal_uvea_morphology1.14004289
89MP0000751_myopathy1.13857290
90MP0005645_abnormal_hypothalamus_physiol1.12859429
91MP0000428_abnormal_craniofacial_morphol1.09672668
92MP0004142_abnormal_muscle_tone1.08977934
93MP0002089_abnormal_postnatal_growth/wei1.07580328
94MP0003075_altered_response_to1.06832223
95MP0003283_abnormal_digestive_organ1.06822971
96MP0001502_abnormal_circadian_rhythm1.05813715
97MP0008961_abnormal_basal_metabolism1.02899380
98MP0010352_gastrointestinal_tract_polyps1.02103511
99MP0002152_abnormal_brain_morphology1.00132209
100MP0002177_abnormal_outer_ear0.98657605
101MP0000759_abnormal_skeletal_muscle0.97202291
102MP0008004_abnormal_stomach_pH0.96503268
103MP0003631_nervous_system_phenotype0.94726991
104MP0005394_taste/olfaction_phenotype0.93567995
105MP0005499_abnormal_olfactory_system0.93567995
106MP0002234_abnormal_pharynx_morphology0.93426679
107MP0000604_amyloidosis0.92554882
108MP0001243_abnormal_dermal_layer0.92087291
109MP0003941_abnormal_skin_development0.92023472
110MP0003122_maternal_imprinting0.91929331
111MP0001915_intracranial_hemorrhage0.91106814
112MP0000049_abnormal_middle_ear0.90802891
113MP0002069_abnormal_eating/drinking_beha0.90446127
114MP0003315_abnormal_perineum_morphology0.90361512
115MP0004085_abnormal_heartbeat0.89935870
116MP0005535_abnormal_body_temperature0.89882291
117MP0000537_abnormal_urethra_morphology0.89767744
118MP0005164_abnormal_response_to0.88971136
119MP0005167_abnormal_blood-brain_barrier0.88801040
120MP0010386_abnormal_urinary_bladder0.87942380
121MP0001177_atelectasis0.87097289
122MP0005171_absent_coat_pigmentation0.86740358
123MP0002932_abnormal_joint_morphology0.86398396
124MP0000013_abnormal_adipose_tissue0.86010221
125MP0005058_abnormal_lysosome_morphology0.85231646
126MP0003448_altered_tumor_morphology0.85162603
127MP0002998_abnormal_bone_remodeling0.84398657
128MP0000762_abnormal_tongue_morphology0.82331963
129MP0001879_abnormal_lymphatic_vessel0.82209732
130MP0004510_myositis0.81725517
131MP0000432_abnormal_head_morphology0.80089977
132MP0003755_abnormal_palate_morphology0.79629053
133MP0003634_abnormal_glial_cell0.78788007
134MP0000749_muscle_degeneration0.78605415
135MP0005390_skeleton_phenotype0.78223287
136MP0002113_abnormal_skeleton_development0.77677650
137MP0000003_abnormal_adipose_tissue0.77178869
138MP0004145_abnormal_muscle_electrophysio0.77122186
139MP0000163_abnormal_cartilage_morphology0.76915788
140MP0000569_abnormal_digit_pigmentation0.73568427
141MP0001348_abnormal_lacrimal_gland0.72992822
142MP0005464_abnormal_platelet_physiology0.72940865
143MP0000631_abnormal_neuroendocrine_gland0.72751258
144MP0000678_abnormal_parathyroid_gland0.72582162
145MP0002108_abnormal_muscle_morphology0.72532380
146MP0003115_abnormal_respiratory_system0.72128281
147MP0003787_abnormal_imprinting0.69841508
148MP0002114_abnormal_axial_skeleton0.68830959
149MP0001664_abnormal_digestion0.68819906
150MP0001614_abnormal_blood_vessel0.68574562
151MP0008775_abnormal_heart_ventricle0.68325556
152MP0002128_abnormal_blood_circulation0.66870369
153MP0004808_abnormal_hematopoietic_stem0.66746292
154MP0002229_neurodegeneration0.65782113
155MP0005623_abnormal_meninges_morphology0.64239342
156MP0003137_abnormal_impulse_conducting0.64023177
157MP0003935_abnormal_craniofacial_develop0.62903084
158MP0002837_dystrophic_cardiac_calcinosis0.61952649
159MP0002752_abnormal_somatic_nervous0.60897588
160MP0008932_abnormal_embryonic_tissue0.59354589
161MP0004742_abnormal_vestibular_system0.58811640
162MP0002090_abnormal_vision0.58709963
163MP0002116_abnormal_craniofacial_bone0.57810404
164MP0002925_abnormal_cardiovascular_devel0.56752523
165MP0000920_abnormal_myelination0.56093678
166MP0003795_abnormal_bone_structure0.56072090
167MP0004134_abnormal_chest_morphology0.54724311
168MP0005187_abnormal_penis_morphology0.54371030
169MP0001943_abnormal_respiration0.54223843
170MP0003937_abnormal_limbs/digits/tail_de0.54087410
171MP0003632_abnormal_nervous_system0.52611070
172MP0003690_abnormal_glial_cell0.52478982
173MP0004233_abnormal_muscle_weight0.51696119
174MP0003861_abnormal_nervous_system0.49640173
175MP0004484_altered_response_of0.49460277
176MP0001963_abnormal_hearing_physiology0.48314980
177MP0002751_abnormal_autonomic_nervous0.46613964
178MP0003956_abnormal_body_size0.46367513
179MP0005166_decreased_susceptibility_to0.44950327
180MP0010769_abnormal_survival0.43044007
181MP0010770_preweaning_lethality0.41276887
182MP0002082_postnatal_lethality0.41276887

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.34360606
2Focal motor seizures (HP:0011153)7.10991104
3Premature rupture of membranes (HP:0001788)6.74945683
4Ankle contracture (HP:0006466)6.18710766
5Protrusio acetabuli (HP:0003179)6.18188201
6Focal seizures (HP:0007359)5.69783727
7Follicular hyperkeratosis (HP:0007502)5.62310389
8Visual hallucinations (HP:0002367)5.34148741
9Type 1 muscle fiber predominance (HP:0003803)5.30472059
10Slender build (HP:0001533)5.30285551
11Spinal rigidity (HP:0003306)4.63071513
12Abnormality of the Achilles tendon (HP:0005109)4.06338052
13Epileptic encephalopathy (HP:0200134)3.92375444
14Atonic seizures (HP:0010819)3.84335903
15Absence seizures (HP:0002121)3.82001145
16Poor eye contact (HP:0000817)3.81744551
17Vertebral compression fractures (HP:0002953)3.78447018
18Mildly elevated creatine phosphokinase (HP:0008180)3.74000588
19Febrile seizures (HP:0002373)3.70257690
20Action tremor (HP:0002345)3.69945708
21Increased variability in muscle fiber diameter (HP:0003557)3.63576553
22Abnormality of dentin (HP:0010299)3.60124519
23Generalized tonic-clonic seizures (HP:0002069)3.55831865
24Supranuclear gaze palsy (HP:0000605)3.55213874
25Aortic dissection (HP:0002647)3.53811250
26Anxiety (HP:0000739)3.52399506
27Dialeptic seizures (HP:0011146)3.48794009
28Ankle clonus (HP:0011448)3.46539770
29Torticollis (HP:0000473)3.44043276
30Abnormal social behavior (HP:0012433)3.41848506
31Impaired social interactions (HP:0000735)3.41848506
32Bladder diverticulum (HP:0000015)3.41687876
33Annular pancreas (HP:0001734)3.37680166
34Progressive cerebellar ataxia (HP:0002073)3.36706220
35Depression (HP:0000716)3.32850194
36Genu recurvatum (HP:0002816)3.29422793
37Papilledema (HP:0001085)3.28195970
38Broad-based gait (HP:0002136)3.27215057
39Vascular tortuosity (HP:0004948)3.25986507
40Aortic aneurysm (HP:0004942)3.19619769
41Soft skin (HP:0000977)3.17658733
42Elbow flexion contracture (HP:0002987)3.17058741
43Abnormality of skeletal muscle fiber size (HP:0012084)3.15652804
44Arterial tortuosity (HP:0005116)3.13106162
45Mutism (HP:0002300)3.10040916
46Amblyopia (HP:0000646)3.08970829
47Impaired vibration sensation in the lower limbs (HP:0002166)3.08213662
48Focal dystonia (HP:0004373)3.02351681
49Shallow orbits (HP:0000586)2.97789198
50Generalized amyotrophy (HP:0003700)2.97236681
51Wormian bones (HP:0002645)2.94419352
52Cerebral inclusion bodies (HP:0100314)2.92111738
53Craniofacial dystonia (HP:0012179)2.91569470
54Stereotypic behavior (HP:0000733)2.90719740
55Fragile skin (HP:0001030)2.85448951
56Overgrowth (HP:0001548)2.84551613
57Ankyloglossia (HP:0010296)2.83034946
58Urinary bladder sphincter dysfunction (HP:0002839)2.79048427
59Distal upper limb amyotrophy (HP:0007149)2.77075052
60Upper limb amyotrophy (HP:0009129)2.77075052
61Limb dystonia (HP:0002451)2.76969459
62Dysdiadochokinesis (HP:0002075)2.75119950
63Increased connective tissue (HP:0009025)2.73051939
64Abnormal eating behavior (HP:0100738)2.72549509
65Blue sclerae (HP:0000592)2.71673973
66Resting tremor (HP:0002322)2.70972265
67Urinary urgency (HP:0000012)2.70570884
68Dysmetria (HP:0001310)2.70006483
69Truncal ataxia (HP:0002078)2.69066366
70Atrophic scars (HP:0001075)2.68325597
71Cervical subluxation (HP:0003308)2.64742810
72Neurofibrillary tangles (HP:0002185)2.63165707
73Termporal pattern (HP:0011008)2.61987745
74Insidious onset (HP:0003587)2.61987745
75Limb-girdle muscle weakness (HP:0003325)2.60497578
76Postural instability (HP:0002172)2.58861398
77Pointed chin (HP:0000307)2.56809062
78Ulnar bowing (HP:0003031)2.55845160
79Distal lower limb amyotrophy (HP:0008944)2.55167791
80Broad metatarsal (HP:0001783)2.54854072
81Progressive inability to walk (HP:0002505)2.52341986
82Long toe (HP:0010511)2.50505710
83Hyperventilation (HP:0002883)2.50100325
84Disproportionate tall stature (HP:0001519)2.48717908
85Excessive salivation (HP:0003781)2.48323337
86Drooling (HP:0002307)2.48323337
87Megalencephaly (HP:0001355)2.47041114
88Biconcave vertebral bodies (HP:0004586)2.44372769
89Joint laxity (HP:0001388)2.44036555
90Neonatal short-limb short stature (HP:0008921)2.41700092
91Lower limb amyotrophy (HP:0007210)2.40630588
92Abnormality of the lower motor neuron (HP:0002366)2.38469050
93Bowel diverticulosis (HP:0005222)2.37877978
94Scanning speech (HP:0002168)2.37525093
95Gaze-evoked nystagmus (HP:0000640)2.36384292
96Wide anterior fontanel (HP:0000260)2.35509712
97Mitral valve prolapse (HP:0001634)2.34017972
98Bradykinesia (HP:0002067)2.31981617
99Spastic gait (HP:0002064)2.31327750
100Protruding ear (HP:0000411)2.30142428
101Renal duplication (HP:0000075)2.29436253
102Amyotrophic lateral sclerosis (HP:0007354)2.27537703
103Epileptiform EEG discharges (HP:0011182)2.25726313
104Hypoventilation (HP:0002791)2.24268554
105Hand muscle atrophy (HP:0009130)2.24091071
106Obstructive sleep apnea (HP:0002870)2.23664601
107Hyperextensible skin (HP:0000974)2.23109526
108Short nail (HP:0001799)2.21723379
109Hyperacusis (HP:0010780)2.21403335
110Dilatation of the ascending aorta (HP:0005111)2.21377775
111Cerebral aneurysm (HP:0004944)2.16785536
112Syringomyelia (HP:0003396)2.16378380
113Spinal cord lesions (HP:0100561)2.16378380
114Apathy (HP:0000741)2.16259686
115EEG with generalized epileptiform discharges (HP:0011198)2.16095652
116Mitral regurgitation (HP:0001653)2.15380358
117Truncus arteriosus (HP:0001660)2.15335058
118Abnormality of binocular vision (HP:0011514)2.13843044
119Diplopia (HP:0000651)2.13843044
120Abnormality of the umbilical cord (HP:0010881)2.13492426
121Genetic anticipation (HP:0003743)2.12897898
122Impaired smooth pursuit (HP:0007772)2.12864725
123Lower limb asymmetry (HP:0100559)2.12680495
124Ventricular fibrillation (HP:0001663)2.12289921
125Lower limb muscle weakness (HP:0007340)2.09690038
126Insomnia (HP:0100785)2.09067622
127Abnormality of oral frenula (HP:0000190)2.08684145
128Abnormal EKG (HP:0003115)2.07333283
129Delusions (HP:0000746)2.05276317
130Hypsarrhythmia (HP:0002521)2.05113700
131Osteolytic defects of the hand bones (HP:0009699)2.04533950
132Osteolytic defects of the phalanges of the hand (HP:0009771)2.04533950
133Impaired pain sensation (HP:0007328)2.03858117
134Abnormality of pain sensation (HP:0010832)2.03858117
135Hemiparesis (HP:0001269)2.02577706
136Increased mean platelet volume (HP:0011877)2.01551817
137Abnormality of the fetal cardiovascular system (HP:0010948)2.01155491
138Abnormal umbilical cord blood vessels (HP:0011403)2.01155491
139Single umbilical artery (HP:0001195)2.01155491
140Absent speech (HP:0001344)2.01107428
141Achilles tendon contracture (HP:0001771)1.98974380
142Incomplete penetrance (HP:0003829)1.98078394
143Polyphagia (HP:0002591)1.97571908
144Hypercortisolism (HP:0001578)1.97234129
145Retinal dysplasia (HP:0007973)1.97040688
146Generalized hypotonia (HP:0001290)1.96945723
147Abnormality of the acetabulum (HP:0003170)1.96849450
148Inability to walk (HP:0002540)1.96464574
149Rapidly progressive (HP:0003678)1.96314590
150Deep palmar crease (HP:0006191)1.96003103
151Fetal akinesia sequence (HP:0001989)1.94988254
152Menorrhagia (HP:0000132)1.94956062
153Pheochromocytoma (HP:0002666)1.93667171
154Deviation of the hallux (HP:0010051)1.92769128
155Diminished motivation (HP:0000745)1.92575264
156Hallux valgus (HP:0001822)1.92261503
157Long palpebral fissure (HP:0000637)1.91713859
158Psychosis (HP:0000709)1.91239287
159Abnormal delivery (HP:0001787)1.89681262
160Natal tooth (HP:0000695)1.89669534
161Bronchomalacia (HP:0002780)1.89518800
162Inappropriate behavior (HP:0000719)1.88952872
163Status epilepticus (HP:0002133)1.88719798
164Arnold-Chiari malformation (HP:0002308)1.88390287
165Poor suck (HP:0002033)1.87952616
166Neuronal loss in central nervous system (HP:0002529)1.87207779
167Abnormality of the corticospinal tract (HP:0002492)1.86723637
168Spondylolisthesis (HP:0003302)1.86684047
169Neoplasm of the peripheral nervous system (HP:0100007)1.86328796
170Bowed forearm bones (HP:0003956)1.86144240
171Bowing of the arm (HP:0006488)1.86144240
172Failure to thrive in infancy (HP:0001531)1.86014118
173Dysmetric saccades (HP:0000641)1.85478605
174Peritonitis (HP:0002586)1.84905926
175Nuclear cataract (HP:0100018)1.83064768
176Coronal craniosynostosis (HP:0004440)1.78119339
177Redundant skin (HP:0001582)1.78052560
178Delayed cranial suture closure (HP:0000270)1.73293848
179Mild short stature (HP:0003502)1.72070220
180Osteopenia (HP:0000938)1.71889721
181Hydroureter (HP:0000072)1.71234276
182Turricephaly (HP:0000262)1.70472585
183Impaired platelet aggregation (HP:0003540)1.69204371
184Abnormal platelet function (HP:0011869)1.69204371
185Breech presentation (HP:0001623)1.69122749
186Wrist flexion contracture (HP:0001239)1.69083750
187Abnormality of the distal phalanges of the toes (HP:0010182)1.68832629
188Abnormal platelet volume (HP:0011876)1.66906475
189Venous abnormality (HP:0002624)1.65772707
190Distal lower limb muscle weakness (HP:0009053)1.65489926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.08680853
2MAP3K94.18996049
3NTRK34.04113830
4IRAK33.78475251
5PDGFRA3.19362676
6KSR23.09652122
7RIPK42.85859254
8MARK12.84354822
9PTK22.82846798
10MINK12.63359053
11MYLK2.61465851
12ERBB42.55989713
13DAPK22.50766111
14EPHB22.39895014
15TTN2.35540178
16NME22.26355449
17NTRK12.26263799
18KSR12.09829028
19ARAF2.07806840
20PAK22.02270417
21MAP3K42.01290721
22ICK1.99714195
23PAK61.98782198
24CAMKK11.93300700
25PRKD31.88301611
26SIK21.86960368
27PAK41.83764577
28NTRK21.83168039
29TESK11.76194794
30GRK51.75755797
31MAP3K131.73412674
32SIK11.69320620
33TAOK21.66197241
34CDK51.62431322
35MAP3K21.62300137
36AKT31.60362573
37FES1.55778762
38DDR21.55307605
39MAP2K71.54225207
40TAOK11.52253890
41FLT31.49361279
42DAPK11.47494132
43ERN11.46844826
44MAP3K121.46426658
45ABL21.38153868
46RAF11.35528300
47TNIK1.30580499
48PIM21.27679179
49ILK1.26362823
50MAP2K41.25684324
51PLK21.24928413
52LMTK21.24580102
53EIF2AK11.23515000
54CDK81.21953724
55LATS11.21884817
56TYRO31.16795953
57MET1.16518973
58CAMKK21.15447268
59PAK11.13346946
60PKN21.11962172
61CDK191.10261831
62UHMK11.06730766
63MAPK131.01210129
64RET1.01070324
65ROCK21.00285824
66EPHA20.99522135
67PRKCG0.98451775
68CDK140.98297394
69PHKG20.96020229
70PHKG10.96020229
71PTK2B0.95982408
72CDK180.94955743
73BMPR20.94807501
74CDK150.92363892
75CAMK2A0.91859128
76LATS20.90813768
77CASK0.88385597
78DYRK1B0.87625685
79TGFBR20.87109231
80PDGFRB0.86043502
81EPHB10.85709399
82STK110.84391450
83PRPF4B0.84121851
84CDK11A0.82472276
85SMG10.81956487
86MAP2K10.81474249
87MAP3K10.78990021
88MTOR0.78353545
89STK380.77651987
90CLK10.77631971
91ROCK10.77089906
92BMX0.76668569
93PNCK0.75411805
94MARK20.71438433
95CAMK2B0.69643839
96MAP2K30.69294776
97GSK3A0.69222112
98IRAK20.68992880
99DYRK30.68855431
100NEK20.65131832
101PTK60.64082768
102ALK0.63655723
103MAP3K80.63507359
104CDC42BPA0.63037944
105PRKCZ0.62605253
106CAMK10.61851555
107MOS0.61494817
108PRKG20.61272918
109SGK10.59846185
110AURKA0.59537710
111CSNK1G20.59293361
112PDPK10.59123088
113PRKCH0.58470842
114PDK10.58180088
115TESK20.58174080
116DYRK1A0.57337618
117FGR0.55452022
118PAK30.54334534
119SCYL20.54207304
120SGK4940.53294365
121SGK2230.53294365
122STK30.52601002
123RPS6KC10.52350715
124RPS6KL10.52350715
125PINK10.50981921
126TNK20.49477520
127CDK70.49239783
128DAPK30.48393939
129FYN0.47464017
130SIK30.46570524
131GRK10.45633527
132WNK10.45566073
133ADRBK20.44587587
134BUB10.43656370
135MAP3K30.43053460
136FER0.42271490
137DMPK0.41855377
138RPS6KA30.41045206
139GRK60.40970500
140PRKCE0.40421220
141BRAF0.39770373
142ADRBK10.39348439
143MAP3K110.38990129
144PIK3CG0.38699625
145AKT20.38535223
146NME10.38208085
147NEK10.38040581
148MUSK0.38027588
149CAMK2G0.37714713
150ZAP700.37530078
151MAP3K100.36997196
152MAPK100.35564973
153SGK20.34577877
154TRIB30.32510829
155RPS6KA20.32311277
156LIMK10.29575268
157BRSK10.28693953
158CAMK2D0.27991499
159SGK30.26468608
160PRKCB0.25959175
161PRKACA0.25408528
162PRKD20.25374658
163RIPK10.24803250

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.17027610
2ECM-receptor interaction_Homo sapiens_hsa045123.04435691
3Olfactory transduction_Homo sapiens_hsa047403.02422854
4Synaptic vesicle cycle_Homo sapiens_hsa047212.94054232
5Bladder cancer_Homo sapiens_hsa052192.85045702
6Long-term potentiation_Homo sapiens_hsa047202.74512270
7Amphetamine addiction_Homo sapiens_hsa050312.58690398
8Circadian entrainment_Homo sapiens_hsa047132.58400664
9Morphine addiction_Homo sapiens_hsa050322.56804394
10GABAergic synapse_Homo sapiens_hsa047272.50194634
11Focal adhesion_Homo sapiens_hsa045102.50006104
12Glutamatergic synapse_Homo sapiens_hsa047242.43296626
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42008497
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37197275
15Dopaminergic synapse_Homo sapiens_hsa047282.32707928
16Cocaine addiction_Homo sapiens_hsa050302.13654053
17Salivary secretion_Homo sapiens_hsa049702.13600483
18Cholinergic synapse_Homo sapiens_hsa047252.02462349
19Renin secretion_Homo sapiens_hsa049242.00161617
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85848763
21Chronic myeloid leukemia_Homo sapiens_hsa052201.83616099
22Proteoglycans in cancer_Homo sapiens_hsa052051.82977862
23Serotonergic synapse_Homo sapiens_hsa047261.80664576
24Melanoma_Homo sapiens_hsa052181.80316044
25Gastric acid secretion_Homo sapiens_hsa049711.79200705
26Insulin secretion_Homo sapiens_hsa049111.74903792
27Oxytocin signaling pathway_Homo sapiens_hsa049211.74594264
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.73451520
29Long-term depression_Homo sapiens_hsa047301.73004884
30Taste transduction_Homo sapiens_hsa047421.68594748
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66620775
32Gap junction_Homo sapiens_hsa045401.65928929
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.65682981
34Calcium signaling pathway_Homo sapiens_hsa040201.61782483
35GnRH signaling pathway_Homo sapiens_hsa049121.52639168
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.49662893
37MicroRNAs in cancer_Homo sapiens_hsa052061.43365337
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35492301
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34642143
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33481777
41Glioma_Homo sapiens_hsa052141.29178609
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29032312
43cAMP signaling pathway_Homo sapiens_hsa040241.27050909
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26304725
45Small cell lung cancer_Homo sapiens_hsa052221.23678307
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.22702305
47Estrogen signaling pathway_Homo sapiens_hsa049151.21784131
48Hippo signaling pathway_Homo sapiens_hsa043901.18136963
49Pancreatic cancer_Homo sapiens_hsa052121.17414056
50Axon guidance_Homo sapiens_hsa043601.15606286
51Basal cell carcinoma_Homo sapiens_hsa052171.15183461
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.14314452
53Protein digestion and absorption_Homo sapiens_hsa049741.14202974
54Amoebiasis_Homo sapiens_hsa051461.13401111
55Melanogenesis_Homo sapiens_hsa049161.12585152
56Collecting duct acid secretion_Homo sapiens_hsa049661.12347744
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09873266
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07060535
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06908400
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06206406
61Pathways in cancer_Homo sapiens_hsa052001.04628051
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.03270815
63ErbB signaling pathway_Homo sapiens_hsa040121.01427623
64Shigellosis_Homo sapiens_hsa051311.01120291
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00394435
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98329000
67Hedgehog signaling pathway_Homo sapiens_hsa043400.96405479
68Prostate cancer_Homo sapiens_hsa052150.96293603
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.95764192
70Cardiac muscle contraction_Homo sapiens_hsa042600.94314269
71VEGF signaling pathway_Homo sapiens_hsa043700.93691535
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93264624
73Oocyte meiosis_Homo sapiens_hsa041140.91913507
74Type II diabetes mellitus_Homo sapiens_hsa049300.89767564
75Adherens junction_Homo sapiens_hsa045200.87787805
76Sulfur relay system_Homo sapiens_hsa041220.87476013
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83124410
78Alcoholism_Homo sapiens_hsa050340.82582874
79Dorso-ventral axis formation_Homo sapiens_hsa043200.82544451
80TGF-beta signaling pathway_Homo sapiens_hsa043500.81941391
81Vibrio cholerae infection_Homo sapiens_hsa051100.81915634
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80512571
83Salmonella infection_Homo sapiens_hsa051320.79869980
84Choline metabolism in cancer_Homo sapiens_hsa052310.79787198
85Pentose phosphate pathway_Homo sapiens_hsa000300.79600077
86Notch signaling pathway_Homo sapiens_hsa043300.77922575
87p53 signaling pathway_Homo sapiens_hsa041150.77329748
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.77286153
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76762288
90Non-small cell lung cancer_Homo sapiens_hsa052230.76468103
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75600741
92Acute myeloid leukemia_Homo sapiens_hsa052210.75022667
93Galactose metabolism_Homo sapiens_hsa000520.74804426
94Pancreatic secretion_Homo sapiens_hsa049720.74045255
95N-Glycan biosynthesis_Homo sapiens_hsa005100.73081432
96Malaria_Homo sapiens_hsa051440.72568881
97Thyroid hormone synthesis_Homo sapiens_hsa049180.71457166
98MAPK signaling pathway_Homo sapiens_hsa040100.70878911
99Rap1 signaling pathway_Homo sapiens_hsa040150.70808420
100Dilated cardiomyopathy_Homo sapiens_hsa054140.67362591
101Phototransduction_Homo sapiens_hsa047440.66252502
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.65487449
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64449343
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64148552
105Ras signaling pathway_Homo sapiens_hsa040140.61490846
106Endometrial cancer_Homo sapiens_hsa052130.60475451
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59048074
108Apoptosis_Homo sapiens_hsa042100.58838176
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57400054
110mTOR signaling pathway_Homo sapiens_hsa041500.56606000
111Cell cycle_Homo sapiens_hsa041100.55148529
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54285471
113HIF-1 signaling pathway_Homo sapiens_hsa040660.54102369
114Renal cell carcinoma_Homo sapiens_hsa052110.53030072
115African trypanosomiasis_Homo sapiens_hsa051430.52805160
116Endocytosis_Homo sapiens_hsa041440.51792310
117Hepatitis B_Homo sapiens_hsa051610.51681089
118Other glycan degradation_Homo sapiens_hsa005110.50894657
119Prion diseases_Homo sapiens_hsa050200.50546922
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50109882
121Thyroid cancer_Homo sapiens_hsa052160.48914232
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48533520
123Glucagon signaling pathway_Homo sapiens_hsa049220.47910331
124Chemokine signaling pathway_Homo sapiens_hsa040620.47362305
125Alzheimers disease_Homo sapiens_hsa050100.47310752
126Type I diabetes mellitus_Homo sapiens_hsa049400.47120148
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47056956
128TNF signaling pathway_Homo sapiens_hsa046680.46191988
129Insulin signaling pathway_Homo sapiens_hsa049100.45242335
130Biosynthesis of amino acids_Homo sapiens_hsa012300.45093383
131Platelet activation_Homo sapiens_hsa046110.45049401
132HTLV-I infection_Homo sapiens_hsa051660.44697448
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43603469
134Lysosome_Homo sapiens_hsa041420.42240253
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41202887
136Wnt signaling pathway_Homo sapiens_hsa043100.40698748
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40280102
138FoxO signaling pathway_Homo sapiens_hsa040680.38963609
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38677125
140Parkinsons disease_Homo sapiens_hsa050120.38116851
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37765812
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36491383
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35608858
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35248254
145Bile secretion_Homo sapiens_hsa049760.34637838
146Colorectal cancer_Homo sapiens_hsa052100.34364828
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.33917631
148Prolactin signaling pathway_Homo sapiens_hsa049170.33615106
149Nitrogen metabolism_Homo sapiens_hsa009100.30455756
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29633822

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