TMEM159

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.03210765
2central nervous system myelination (GO:0022010)6.94645103
3axon ensheathment in central nervous system (GO:0032291)6.94645103
4long-chain fatty acid biosynthetic process (GO:0042759)6.68818387
5actin-myosin filament sliding (GO:0033275)5.74162065
6muscle filament sliding (GO:0030049)5.74162065
7cholesterol biosynthetic process (GO:0006695)5.72952210
8sterol biosynthetic process (GO:0016126)5.12007125
9actin-mediated cell contraction (GO:0070252)4.82470499
10regulation of skeletal muscle contraction (GO:0014819)4.76054223
11axon ensheathment (GO:0008366)4.54803481
12ensheathment of neurons (GO:0007272)4.54803481
13myelination (GO:0042552)4.51711419
14isoprenoid biosynthetic process (GO:0008299)4.47565916
15amyloid precursor protein metabolic process (GO:0042982)4.37867518
16sarcoplasmic reticulum calcium ion transport (GO:0070296)4.35921623
17platelet dense granule organization (GO:0060155)4.33454681
18proteasome assembly (GO:0043248)4.07679298
19regulation of relaxation of muscle (GO:1901077)4.05006122
20skeletal muscle contraction (GO:0003009)4.03675287
21ubiquinone biosynthetic process (GO:0006744)4.00367809
22long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.97857107
23long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.92520145
24response to redox state (GO:0051775)3.88785410
25behavioral response to nicotine (GO:0035095)3.85624873
26regulation of collateral sprouting (GO:0048670)3.79535297
27protein complex biogenesis (GO:0070271)3.70601887
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.69421073
29amyloid precursor protein catabolic process (GO:0042987)3.68910536
30protein neddylation (GO:0045116)3.67274983
31ubiquinone metabolic process (GO:0006743)3.66055824
32GPI anchor biosynthetic process (GO:0006506)3.66006128
33adhesion of symbiont to host cell (GO:0044650)3.62016826
34virion attachment to host cell (GO:0019062)3.62016826
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.61250432
36NADH dehydrogenase complex assembly (GO:0010257)3.61250432
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61250432
38sarcomere organization (GO:0045214)3.52701015
39regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.50093345
40L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.48683670
41phosphatidylserine acyl-chain remodeling (GO:0036150)3.46464468
42fatty-acyl-CoA metabolic process (GO:0035337)3.43792229
43creatine metabolic process (GO:0006600)3.42761525
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40244067
45sphingoid metabolic process (GO:0046519)3.38562754
46response to lipoprotein particle (GO:0055094)3.37078041
47sphingosine metabolic process (GO:0006670)3.33970584
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32710421
49fatty-acyl-CoA biosynthetic process (GO:0046949)3.30978186
50otic vesicle formation (GO:0030916)3.30486120
51negative regulation of protein localization to cell surface (GO:2000009)3.29934751
52kynurenine metabolic process (GO:0070189)3.27695235
53heart process (GO:0003015)3.24930358
54heart contraction (GO:0060047)3.24930358
55keratinocyte development (GO:0003334)3.24788309
56striated muscle contraction (GO:0006941)3.24414379
57regulation of cell proliferation involved in kidney development (GO:1901722)3.24105245
58ATP synthesis coupled proton transport (GO:0015986)3.23083337
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23083337
60mitochondrial respiratory chain complex assembly (GO:0033108)3.22505941
61positive regulation of actin filament depolymerization (GO:0030836)3.21136990
62chaperone-mediated protein transport (GO:0072321)3.19444949
63adenosine metabolic process (GO:0046085)3.18772009
64estrogen biosynthetic process (GO:0006703)3.18497686
65nucleotide transmembrane transport (GO:1901679)3.17409153
66cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.17232405
67response to inactivity (GO:0014854)3.16543694
68water-soluble vitamin biosynthetic process (GO:0042364)3.15940111
69cornea development in camera-type eye (GO:0061303)3.13887793
70transcription elongation from RNA polymerase III promoter (GO:0006385)3.11480910
71termination of RNA polymerase III transcription (GO:0006386)3.11480910
72GPI anchor metabolic process (GO:0006505)3.11262359
73positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.09097746
74signal peptide processing (GO:0006465)3.08395482
75sequestering of actin monomers (GO:0042989)3.07642708
76photoreceptor cell differentiation (GO:0046530)3.06471248
77eye photoreceptor cell differentiation (GO:0001754)3.06471248
78regulation of sequestering of triglyceride (GO:0010889)3.05606563
79negative regulation of calcium ion transmembrane transport (GO:1903170)3.05409029
80negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.05409029
81L-methionine salvage (GO:0071267)3.04908982
82L-methionine biosynthetic process (GO:0071265)3.04908982
83amino acid salvage (GO:0043102)3.04908982
84respiratory chain complex IV assembly (GO:0008535)3.03377691
85myofibril assembly (GO:0030239)3.02743667
86DNA deamination (GO:0045006)3.01259710
87preassembly of GPI anchor in ER membrane (GO:0016254)2.99573523
88diol metabolic process (GO:0034311)2.97918615
89regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.97596139
90quinone biosynthetic process (GO:1901663)2.97445624
91cullin deneddylation (GO:0010388)2.97359292
92phosphatidylserine metabolic process (GO:0006658)2.96225600
93response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.94999085
94positive regulation of mitochondrial fission (GO:0090141)2.92829648
95actin filament-based movement (GO:0030048)2.92662784
96calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.91794632
97aspartate family amino acid catabolic process (GO:0009068)2.91417236
98somite development (GO:0061053)2.89745841
99positive regulation of pseudopodium assembly (GO:0031274)2.89531841
100cyclooxygenase pathway (GO:0019371)2.88846286
101myotube cell development (GO:0014904)2.88212492
102response to muscle activity (GO:0014850)2.87921339
103establishment of protein localization to mitochondrial membrane (GO:0090151)2.86905698
104peptidyl-histidine modification (GO:0018202)2.86461950
105substantia nigra development (GO:0021762)2.86258940
106amino sugar catabolic process (GO:0046348)2.86240380
107regulation of cilium movement (GO:0003352)2.85530953
108oxidative phosphorylation (GO:0006119)2.83654591
109acyl-CoA biosynthetic process (GO:0071616)2.83577262
110thioester biosynthetic process (GO:0035384)2.83577262
111peripheral nervous system axon ensheathment (GO:0032292)2.83224330
112myelination in peripheral nervous system (GO:0022011)2.83224330
113pyrimidine-containing compound transmembrane transport (GO:0072531)2.82405233
114alcohol biosynthetic process (GO:0046165)2.81723634
115mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.81672589
116positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.81672589
117positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.79933532
118glycosylceramide metabolic process (GO:0006677)2.79560194
119regulation of sarcomere organization (GO:0060297)2.78497093
120tissue regeneration (GO:0042246)2.77928097
121protein deneddylation (GO:0000338)2.77675018
122muscle fiber development (GO:0048747)2.76489183
123regulation of pseudopodium assembly (GO:0031272)2.76245246
124mannosylation (GO:0097502)2.76164378
125regulation of cellular amino acid metabolic process (GO:0006521)2.74681621
126negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73788589
127alditol phosphate metabolic process (GO:0052646)2.73732584
128skeletal muscle fiber development (GO:0048741)2.73152447
129cytochrome complex assembly (GO:0017004)2.72340491
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71813236
131indole-containing compound catabolic process (GO:0042436)2.71215783
132indolalkylamine catabolic process (GO:0046218)2.71215783
133tryptophan catabolic process (GO:0006569)2.71215783
134myelin maintenance (GO:0043217)2.71124090
135establishment of skin barrier (GO:0061436)2.70501641
136intestinal epithelial cell development (GO:0060576)2.69356694
137phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.68992486
138adhesion of symbiont to host (GO:0044406)2.67949856
139regulation of glucokinase activity (GO:0033131)2.66732565
140regulation of hexokinase activity (GO:1903299)2.66732565
141L-amino acid import (GO:0043092)2.65499252
142magnesium ion transport (GO:0015693)2.65426756
143branched-chain amino acid catabolic process (GO:0009083)2.65335609
144phosphatidylinositol acyl-chain remodeling (GO:0036149)2.64717974
145regulation of water loss via skin (GO:0033561)2.64607493
146respiratory electron transport chain (GO:0022904)2.64030961
147autophagic vacuole fusion (GO:0000046)2.63890953
148terpenoid biosynthetic process (GO:0016114)2.63881153
1497-methylguanosine mRNA capping (GO:0006370)2.63715260
150import into cell (GO:0098657)2.61511700
151glycerophospholipid catabolic process (GO:0046475)2.61437130
152muscle contraction (GO:0006936)2.61399280
153regulation of cell communication by electrical coupling (GO:0010649)2.60123858
154negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60047456
155negative regulation of ligase activity (GO:0051352)2.60047456
156proton transport (GO:0015992)2.58303420
157positive regulation of mitochondrial membrane permeability (GO:0035794)2.58177700
158electron transport chain (GO:0022900)2.57443896
159negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.57221755
160peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.57220913
161RNA capping (GO:0036260)2.57164729
1627-methylguanosine RNA capping (GO:0009452)2.57164729
163cytidine metabolic process (GO:0046087)2.56984376
164cytidine catabolic process (GO:0006216)2.56984376
165cytidine deamination (GO:0009972)2.56984376
166indolalkylamine metabolic process (GO:0006586)2.55815428
167DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.55277042
168hydrogen ion transmembrane transport (GO:1902600)2.54595813
169hydrogen transport (GO:0006818)2.54505041
170regulation of actin filament-based movement (GO:1903115)2.53773619
171negative regulation of telomere maintenance (GO:0032205)2.53142472
172fatty acid transmembrane transport (GO:1902001)2.52783206
173cardiac myofibril assembly (GO:0055003)2.51955408
174detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51455683
175lysine catabolic process (GO:0006554)2.51264486
176lysine metabolic process (GO:0006553)2.51264486
177regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50792002
178adult heart development (GO:0007512)2.49278175
179tryptophan metabolic process (GO:0006568)2.49201250
180nonmotile primary cilium assembly (GO:0035058)2.48564601
181protein-cofactor linkage (GO:0018065)2.47353745
182negative regulation of response to food (GO:0032096)2.46813986
183negative regulation of appetite (GO:0032099)2.46813986
184regulation of membrane repolarization (GO:0060306)2.46412694
185limb bud formation (GO:0060174)2.45933088
186synaptic transmission, cholinergic (GO:0007271)2.45891414
187lipid particle organization (GO:0034389)2.45679650
188negative regulation of systemic arterial blood pressure (GO:0003085)2.38437395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.50460728
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.45758464
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.89160240
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.73493886
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.65394492
6ZNF274_21170338_ChIP-Seq_K562_Hela3.50255618
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93142226
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84482238
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.76359682
10GBX2_23144817_ChIP-Seq_PC3_Human2.70136474
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44874496
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.34248539
13EZH2_22144423_ChIP-Seq_EOC_Human2.32969085
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31059980
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30620590
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21459109
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17886644
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.16901393
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.15759540
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10895268
21IGF1R_20145208_ChIP-Seq_DFB_Human2.10665847
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.06353980
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.01481507
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00566785
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94387411
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94387411
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94387411
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.93687844
29P300_19829295_ChIP-Seq_ESCs_Human1.90418094
30* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89346068
31TAF15_26573619_Chip-Seq_HEK293_Human1.88062950
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87595793
33ELK1_22589737_ChIP-Seq_MCF10A_Human1.87258162
34FUS_26573619_Chip-Seq_HEK293_Human1.86269927
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86073165
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80136320
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77200453
38SOX2_20726797_ChIP-Seq_SW620_Human1.70511442
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68339314
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56509241
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53551827
42* SRF_21415370_ChIP-Seq_HL-1_Mouse1.47926672
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46927248
44EOMES_21245162_ChIP-Seq_HESCs_Human1.45328741
45CBP_20019798_ChIP-Seq_JUKART_Human1.45022587
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45022587
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42251852
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42235405
49BCAT_22108803_ChIP-Seq_LS180_Human1.42187821
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41107422
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38757460
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37810864
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37498883
54SMAD4_21799915_ChIP-Seq_A2780_Human1.36647897
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35828935
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35452297
57SOX17_20123909_ChIP-Seq_XEN_Mouse1.35253480
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.35027333
59* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35004905
60* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35004905
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.34868114
62TP53_22573176_ChIP-Seq_HFKS_Human1.33854408
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31183731
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.30241140
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29490773
66ER_23166858_ChIP-Seq_MCF-7_Human1.27745973
67AR_20517297_ChIP-Seq_VCAP_Human1.27578355
68MYC_18940864_ChIP-ChIP_HL60_Human1.26214380
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.23944526
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.23805467
71AR_25329375_ChIP-Seq_VCAP_Human1.23369382
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23034109
73CDX2_22108803_ChIP-Seq_LS180_Human1.22471825
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21898189
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21561742
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21383488
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21089436
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20018615
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.19047236
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19047236
81EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18260818
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18040608
83ELK1_19687146_ChIP-ChIP_HELA_Human1.17121545
84HOXB7_26014856_ChIP-Seq_BT474_Human1.16162986
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.15604421
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14772481
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14347001
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.12893093
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12659718
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12441311
91TCF4_22108803_ChIP-Seq_LS180_Human1.12157493
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.11314807
93AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11190075
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08687629
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08641214
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.07931613
97NCOR_22424771_ChIP-Seq_293T_Human1.06887400
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05164808
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02028909
100NANOG_20526341_ChIP-Seq_ESCs_Human1.00967212
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.00962672
102TCF4_23295773_ChIP-Seq_U87_Human1.00690263
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00208121
104STAT3_23295773_ChIP-Seq_U87_Human0.99999196
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99866216
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.99778045
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99321174
108GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98828092
109P53_22387025_ChIP-Seq_ESCs_Mouse0.98459933
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97730407
111* GATA4_25053715_ChIP-Seq_YYC3_Human0.97595527
112STAT3_18555785_Chip-Seq_ESCs_Mouse0.97088089
113VDR_23849224_ChIP-Seq_CD4+_Human0.96876546
114BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96844958
115EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96424606
116ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96238695
117SMAD3_21741376_ChIP-Seq_EPCs_Human0.96081507
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94945562
119CJUN_26792858_Chip-Seq_BT549_Human0.94382731
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93905920
121MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93893716
122FOXH1_21741376_ChIP-Seq_ESCs_Human0.93672537
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.93415575
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.92454077
125SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92120625
126VDR_22108803_ChIP-Seq_LS180_Human0.90382211
127* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89477245
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89252649
129* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88276455
130RBPJ_21746931_ChIP-Seq_IB4_Human0.88230093
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86500813
132IRF1_19129219_ChIP-ChIP_H3396_Human0.85965285
133HTT_18923047_ChIP-ChIP_STHdh_Human0.85098381
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84690568
135NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84572340
136GATA6_21074721_ChIP-Seq_CACO-2_Human0.83615866
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81313478
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80480988
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80099272
140CTCF_20526341_ChIP-Seq_ESCs_Human0.78353690
141PHF8_20622853_ChIP-Seq_HELA_Human0.77410368
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.76605390
143ZNF263_19887448_ChIP-Seq_K562_Human0.74741386
144HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.74733001
145CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74579705
146NANOG_19829295_ChIP-Seq_ESCs_Human0.74518894
147SOX2_19829295_ChIP-Seq_ESCs_Human0.74518894
148PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74395649
149KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73690295
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.71562714
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71480557
152SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.70762316
153SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.70762316
154RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70505970
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70012021
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.67999007
157EWS_26573619_Chip-Seq_HEK293_Human0.67827790
158CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.67511556
159PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.67511174
160GATA3_24758297_ChIP-Seq_MCF-7_Human0.67226569
161BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66821690
162FOXA1_21572438_ChIP-Seq_LNCaP_Human0.66449303
163SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66378764
164* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.66096486
165SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.64904047
166ETV2_25802403_ChIP-Seq_MESCs_Mouse0.64490003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.16329723
2MP0004145_abnormal_muscle_electrophysio4.31180236
3MP0002837_dystrophic_cardiac_calcinosis4.08719313
4MP0000920_abnormal_myelination3.74485368
5MP0000751_myopathy3.62020227
6MP0000749_muscle_degeneration3.54460710
7MP0003950_abnormal_plasma_membrane3.19898891
8MP0008260_abnormal_autophagy3.01425333
9MP0008438_abnormal_cutaneous_collagen2.99633335
10MP0003136_yellow_coat_color2.92561390
11MP0005275_abnormal_skin_tensile2.82165201
12MP0005171_absent_coat_pigmentation2.73700572
13MP0005451_abnormal_body_composition2.73590187
14MP0002796_impaired_skin_barrier2.68587126
15MP0004381_abnormal_hair_follicle2.67367291
16MP0004215_abnormal_myocardial_fiber2.59902242
17MP0005058_abnormal_lysosome_morphology2.58700093
18MP0000383_abnormal_hair_follicle2.54670361
19MP0010678_abnormal_skin_adnexa2.45373943
20MP0001542_abnormal_bone_strength2.38974661
21MP0000647_abnormal_sebaceous_gland2.37952933
22MP0000372_irregular_coat_pigmentation2.37185687
23MP0001661_extended_life_span2.25567086
24MP0005620_abnormal_muscle_contractility2.24827380
25MP0002106_abnormal_muscle_physiology2.12003513
26MP0002295_abnormal_pulmonary_circulatio2.08353890
27MP0003690_abnormal_glial_cell2.08214939
28MP0002638_abnormal_pupillary_reflex2.02770646
29MP0008775_abnormal_heart_ventricle1.99477045
30MP0002332_abnormal_exercise_endurance1.97247410
31MP0008789_abnormal_olfactory_epithelium1.97233174
32MP0006036_abnormal_mitochondrial_physio1.95915696
33MP0001346_abnormal_lacrimal_gland1.95232211
34MP0003718_maternal_effect1.91142107
35MP0002972_abnormal_cardiac_muscle1.89669009
36MP0005369_muscle_phenotype1.88773240
37MP0004272_abnormal_basement_membrane1.83633547
38MP0004484_altered_response_of1.83604058
39MP0005646_abnormal_pituitary_gland1.83449479
40MP0002102_abnormal_ear_morphology1.80963497
41MP0006276_abnormal_autonomic_nervous1.77890190
42MP0004130_abnormal_muscle_cell1.72843754
43MP0001905_abnormal_dopamine_level1.70082687
44MP0004742_abnormal_vestibular_system1.64474802
45MP0003195_calcinosis1.64440570
46MP0002653_abnormal_ependyma_morphology1.63487092
47MP0004147_increased_porphyrin_level1.63018406
48MP0005670_abnormal_white_adipose1.61770851
49MP0000762_abnormal_tongue_morphology1.61143389
50MP0004087_abnormal_muscle_fiber1.60815830
51MP0009840_abnormal_foam_cell1.60709989
52MP0001485_abnormal_pinna_reflex1.59096816
53MP0000462_abnormal_digestive_system1.57020886
54MP0003941_abnormal_skin_development1.55988383
55MP0004885_abnormal_endolymph1.55311339
56MP0005503_abnormal_tendon_morphology1.54017735
57MP0000613_abnormal_salivary_gland1.51350054
58MP0006292_abnormal_olfactory_placode1.50636165
59MP0005310_abnormal_salivary_gland1.47839944
60MP0002098_abnormal_vibrissa_morphology1.46933625
61MP0001529_abnormal_vocalization1.40915299
62MP0004043_abnormal_pH_regulation1.40411791
63MP0004782_abnormal_surfactant_physiolog1.40258185
64MP0002269_muscular_atrophy1.39450015
65MP0002163_abnormal_gland_morphology1.35911433
66MP0003137_abnormal_impulse_conducting1.35189050
67MP0003724_increased_susceptibility_to1.34736941
68MP0005551_abnormal_eye_electrophysiolog1.32624831
69MP0001958_emphysema1.32619707
70MP0006072_abnormal_retinal_apoptosis1.32607263
71MP0003634_abnormal_glial_cell1.31719309
72MP0002108_abnormal_muscle_morphology1.31574580
73MP0001544_abnormal_cardiovascular_syste1.31416403
74MP0005385_cardiovascular_system_phenoty1.31416403
75MP0003186_abnormal_redox_activity1.31079688
76MP0002060_abnormal_skin_morphology1.30759742
77MP0000759_abnormal_skeletal_muscle1.28556772
78MP0006082_CNS_inflammation1.28496568
79MP0005501_abnormal_skin_physiology1.28179724
80MP0003878_abnormal_ear_physiology1.26889468
81MP0005377_hearing/vestibular/ear_phenot1.26889468
82MP0003011_delayed_dark_adaptation1.26018187
83MP0005408_hypopigmentation1.25781553
84MP0002009_preneoplasia1.25674071
85MP0003329_amyloid_beta_deposits1.25077976
86MP0005266_abnormal_metabolism1.20888925
87MP0004085_abnormal_heartbeat1.19841804
88MP0004036_abnormal_muscle_relaxation1.18355802
89MP0001727_abnormal_embryo_implantation1.18158216
90MP0008877_abnormal_DNA_methylation1.17450130
91MP0001851_eye_inflammation1.16481903
92MP0008872_abnormal_physiological_respon1.14584410
93MP0002127_abnormal_cardiovascular_syste1.13653654
94MP0009780_abnormal_chondrocyte_physiolo1.13240631
95MP0003453_abnormal_keratinocyte_physiol1.12886305
96MP0004142_abnormal_muscle_tone1.10159852
97MP0002282_abnormal_trachea_morphology1.09946515
98MP0001216_abnormal_epidermal_layer1.09331825
99MP0004134_abnormal_chest_morphology1.08984748
100MP0002277_abnormal_respiratory_mucosa1.08287903
101MP0002133_abnormal_respiratory_system1.07742358
102MP0005388_respiratory_system_phenotype1.07742358
103MP0002132_abnormal_respiratory_system1.06848631
104MP0001984_abnormal_olfaction1.05602186
105MP0005508_abnormal_skeleton_morphology1.04934535
106MP0002876_abnormal_thyroid_physiology1.04130986
107MP0010771_integument_phenotype1.02974127
108MP0000377_abnormal_hair_follicle1.02734959
109MP0005645_abnormal_hypothalamus_physiol1.00629118
110MP0003787_abnormal_imprinting1.00014357
111MP0004185_abnormal_adipocyte_glucose0.99418035
112MP0002736_abnormal_nociception_after0.99071662
113MP0005409_darkened_coat_color0.97120222
114MP0002090_abnormal_vision0.95591612
115MP0002751_abnormal_autonomic_nervous0.95538277
116MP0002234_abnormal_pharynx_morphology0.95278107
117MP0004133_heterotaxia0.95225417
118MP0005253_abnormal_eye_physiology0.94677329
119MP0002148_abnormal_hypersensitivity_rea0.94444351
120MP0000579_abnormal_nail_morphology0.94046108
121MP0000427_abnormal_hair_cycle0.93515855
122MP0005084_abnormal_gallbladder_morpholo0.93069013
123MP0005394_taste/olfaction_phenotype0.91733452
124MP0005499_abnormal_olfactory_system0.91733452
125MP0001243_abnormal_dermal_layer0.91223527
126MP0000747_muscle_weakness0.90726167
127MP0009250_abnormal_appendicular_skeleto0.89520864
128MP0005410_abnormal_fertilization0.89119891
129MP0000465_gastrointestinal_hemorrhage0.89086939
130MP0003315_abnormal_perineum_morphology0.88251664
131MP0005395_other_phenotype0.87750692
132MP0003632_abnormal_nervous_system0.85782979
133MP0005379_endocrine/exocrine_gland_phen0.85628205
134MP0000516_abnormal_urinary_system0.84019513
135MP0005367_renal/urinary_system_phenotyp0.84019513
136MP0001177_atelectasis0.83369717
137MP0003880_abnormal_central_pattern0.83141732
138MP0002160_abnormal_reproductive_system0.82753995
139MP0001756_abnormal_urination0.82436625
140MP0003938_abnormal_ear_development0.82287149
141MP0000049_abnormal_middle_ear0.81128214
142MP0005623_abnormal_meninges_morphology0.78753636
143MP0001968_abnormal_touch/_nociception0.78094412
144MP0002229_neurodegeneration0.75494729
145MP0004084_abnormal_cardiac_muscle0.75339918
146MP0009379_abnormal_foot_pigmentation0.75164611
147MP0000681_abnormal_thyroid_gland0.74946879
148MP0003828_pulmonary_edema0.74816098
149MP0003638_abnormal_response/metabolism_0.73470125
150MP0004233_abnormal_muscle_weight0.73297159
151MP0004510_myositis0.72068353
152MP0000467_abnormal_esophagus_morphology0.71012966
153MP0003806_abnormal_nucleotide_metabolis0.69014787
154MP0000013_abnormal_adipose_tissue0.68829082
155MP0000631_abnormal_neuroendocrine_gland0.68534239
156MP0010386_abnormal_urinary_bladder0.67268042
157MP0005083_abnormal_biliary_tract0.67085140
158MP0006035_abnormal_mitochondrial_morpho0.65974917
159MP0005330_cardiomyopathy0.65967251
160MP0005167_abnormal_blood-brain_barrier0.65778725
161MP0000750_abnormal_muscle_regeneration0.65065331
162MP0002938_white_spotting0.62930663
163MP0001440_abnormal_grooming_behavior0.62682660
164MP0010030_abnormal_orbit_morphology0.61539853
165MP0006138_congestive_heart_failure0.61391011
166MP0002254_reproductive_system_inflammat0.60610759
167MP0001963_abnormal_hearing_physiology0.60417426
168MP0000230_abnormal_systemic_arterial0.60307937

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.28691357
2Muscle fiber inclusion bodies (HP:0100299)6.22809154
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.02106436
4Parakeratosis (HP:0001036)5.85823182
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.39836176
6Exercise-induced muscle cramps (HP:0003710)4.75841295
7Congenital ichthyosiform erythroderma (HP:0007431)4.68979825
8Type 1 muscle fiber predominance (HP:0003803)4.67141935
9Muscle hypertrophy of the lower extremities (HP:0008968)4.36672621
10Calf muscle hypertrophy (HP:0008981)4.20194308
11Cerebral hypomyelination (HP:0006808)4.02494455
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.57216146
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.57216146
14Abnormality of the calf musculature (HP:0001430)3.53616334
15Exercise-induced myalgia (HP:0003738)3.50543797
16Abnormality of glycolysis (HP:0004366)3.44562672
17Increased serum pyruvate (HP:0003542)3.44562672
18Distal arthrogryposis (HP:0005684)3.23633369
19Rimmed vacuoles (HP:0003805)3.20518570
20True hermaphroditism (HP:0010459)3.16122175
21Pancreatic cysts (HP:0001737)3.09646286
22Myoglobinuria (HP:0002913)3.07839374
23Hyporeflexia of lower limbs (HP:0002600)3.06018363
24Abnormality of the umbilical cord (HP:0010881)3.05394056
25Acute necrotizing encephalopathy (HP:0006965)3.04627513
26Neurofibrillary tangles (HP:0002185)3.03860200
27Prolonged neonatal jaundice (HP:0006579)2.99281265
28Pancreatic fibrosis (HP:0100732)2.98161437
29Sensory axonal neuropathy (HP:0003390)2.94606623
30EMG: myopathic abnormalities (HP:0003458)2.91535921
31Bundle branch block (HP:0011710)2.82290433
32Renal Fanconi syndrome (HP:0001994)2.81259231
33Hepatosplenomegaly (HP:0001433)2.75946242
34Spastic paraparesis (HP:0002313)2.75161081
35Mitochondrial inheritance (HP:0001427)2.65412133
36Muscle fiber splitting (HP:0003555)2.64493728
37Patchy hypopigmentation of hair (HP:0011365)2.64418765
38Increased hepatocellular lipid droplets (HP:0006565)2.64068494
39Neck muscle weakness (HP:0000467)2.62777406
40Absent phalangeal crease (HP:0006109)2.62117778
41Premature rupture of membranes (HP:0001788)2.59824198
42Sudden death (HP:0001699)2.59476291
43Abnormality of midbrain morphology (HP:0002418)2.59056154
44Molar tooth sign on MRI (HP:0002419)2.59056154
45Rhabdomyolysis (HP:0003201)2.57958975
46Stenosis of the external auditory canal (HP:0000402)2.56607094
47Segmental peripheral demyelination/remyelination (HP:0003481)2.53856274
48Abnormal umbilical cord blood vessels (HP:0011403)2.53101636
49Single umbilical artery (HP:0001195)2.53101636
50Abnormality of the fetal cardiovascular system (HP:0010948)2.53101636
51Adrenal hypoplasia (HP:0000835)2.51942015
52Congenital malformation of the right heart (HP:0011723)2.51795021
53Double outlet right ventricle (HP:0001719)2.51795021
54Abnormalities of placenta or umbilical cord (HP:0001194)2.50861419
55Leukodystrophy (HP:0002415)2.48152904
56Abnormal mitochondria in muscle tissue (HP:0008316)2.47586071
57Medial flaring of the eyebrow (HP:0010747)2.47047046
58Hepatic necrosis (HP:0002605)2.43891612
59Hepatocellular necrosis (HP:0001404)2.43196786
603-Methylglutaconic aciduria (HP:0003535)2.42895952
61Nephronophthisis (HP:0000090)2.41923805
62Lipid accumulation in hepatocytes (HP:0006561)2.41447659
63CNS hypomyelination (HP:0003429)2.39129073
64White forelock (HP:0002211)2.37778810
65Peripheral hypomyelination (HP:0007182)2.36606556
66Oligomenorrhea (HP:0000876)2.34668718
67Abnormality of placental membranes (HP:0011409)2.33631254
68Amniotic constriction ring (HP:0009775)2.33631254
69Progressive macrocephaly (HP:0004481)2.32248374
70Exercise intolerance (HP:0003546)2.31763055
71Ileus (HP:0002595)2.29104970
72Erythroderma (HP:0001019)2.29041063
73Conical tooth (HP:0000698)2.29028644
74Acute encephalopathy (HP:0006846)2.28863064
75Abnormal finger flexion creases (HP:0006143)2.25268084
76Myotonia (HP:0002486)2.24378766
77Abnormality of the renal cortex (HP:0011035)2.23924430
78Vacuolated lymphocytes (HP:0001922)2.22665390
79Aplasia/Hypoplasia involving the musculature (HP:0001460)2.22628671
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22460264
81Abnormality of alanine metabolism (HP:0010916)2.22460264
82Hyperalaninemia (HP:0003348)2.22460264
83Cerebral edema (HP:0002181)2.22229286
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.20548854
85Osteolytic defects of the hand bones (HP:0009699)2.20548854
86Myopathic facies (HP:0002058)2.20337792
87Abnormality of macrophages (HP:0004311)2.18823536
88Renal cortical cysts (HP:0000803)2.17849683
89Areflexia of lower limbs (HP:0002522)2.15962935
90Cerebral hemorrhage (HP:0001342)2.15922898
91Ulnar deviation of the wrist (HP:0003049)2.15566337
92Split foot (HP:0001839)2.14525365
93Type II lissencephaly (HP:0007260)2.13588694
94Aplasia of the musculature (HP:0100854)2.12014937
95Abnormal hemoglobin (HP:0011902)2.11442663
96Aplasia/hypoplasia of the uterus (HP:0008684)2.11370034
97Left ventricular hypertrophy (HP:0001712)2.09587285
98Abnormality of the renal medulla (HP:0100957)2.08843022
99Congenital, generalized hypertrichosis (HP:0004540)2.08452979
100Aplasia/Hypoplasia of the tongue (HP:0010295)2.08216591
101Hypoplastic pelvis (HP:0008839)2.08168471
102Lactic acidosis (HP:0003128)2.06410410
103Increased intramyocellular lipid droplets (HP:0012240)2.05849412
104Abnormality of the corticospinal tract (HP:0002492)2.05348043
105Aplasia/Hypoplasia of the fovea (HP:0008060)2.04981842
106Hypoplasia of the fovea (HP:0007750)2.04981842
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03441094
108Optic disc pallor (HP:0000543)2.02292003
109Cupped ear (HP:0000378)2.02270601
110Congenital stationary night blindness (HP:0007642)2.02205281
111Abnormality of secondary sexual hair (HP:0009888)2.01733931
112Abnormality of the axillary hair (HP:0100134)2.01733931
113Breast hypoplasia (HP:0003187)2.01569337
114Retinal dysplasia (HP:0007973)2.00358669
115Methylmalonic acidemia (HP:0002912)1.99735405
116Pendular nystagmus (HP:0012043)1.99637567
117Ventricular tachycardia (HP:0004756)1.99588910
118Increased CSF lactate (HP:0002490)1.99334402
119Onion bulb formation (HP:0003383)1.96634042
120Postnatal microcephaly (HP:0005484)1.96472418
121Abnormality of renal resorption (HP:0011038)1.95894141
122Type 2 muscle fiber atrophy (HP:0003554)1.95341815
123Palpitations (HP:0001962)1.94751737
124Hypoplasia of the uterus (HP:0000013)1.94277357
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94011831
126Dilated cardiomyopathy (HP:0001644)1.92462745
127Furrowed tongue (HP:0000221)1.92079995
128Increased muscle lipid content (HP:0009058)1.91658332
129Respiratory failure (HP:0002878)1.91444156
130Gait imbalance (HP:0002141)1.91433956
131Syncope (HP:0001279)1.91411180
132Stridor (HP:0010307)1.89931518
133Distal lower limb muscle weakness (HP:0009053)1.89855302
134Premature skin wrinkling (HP:0100678)1.89425957
135Hypokalemic alkalosis (HP:0001949)1.89072763
136Absent hand (HP:0004050)1.88900507
137Abnormality of the neuromuscular junction (HP:0003398)1.88855507
138Fatigable weakness (HP:0003473)1.88855507
139Lipoatrophy (HP:0100578)1.88848049
140Frequent falls (HP:0002359)1.88716797
141EMG: neuropathic changes (HP:0003445)1.87863905
142Morphological abnormality of the inner ear (HP:0011390)1.86785031
143Abolished electroretinogram (ERG) (HP:0000550)1.86660816
144Keratoconus (HP:0000563)1.86554480
145Increased corneal curvature (HP:0100692)1.86554480
146Nephrogenic diabetes insipidus (HP:0009806)1.86099622
147Congenital primary aphakia (HP:0007707)1.86013403
148Thick nail (HP:0001805)1.84101090
149Methylmalonic aciduria (HP:0012120)1.83950057
150Abnormality of glycolipid metabolism (HP:0010969)1.83018205
151Abnormality of liposaccharide metabolism (HP:0010968)1.83018205
152Abnormality of glycosphingolipid metabolism (HP:0004343)1.83018205
153Round ear (HP:0100830)1.82800573
154Decreased central vision (HP:0007663)1.82783437
155Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81837510
156Increased serum lactate (HP:0002151)1.81778722
157Delayed epiphyseal ossification (HP:0002663)1.81761357
158Anomalous pulmonary venous return (HP:0010772)1.80586318
159Abnormal rod and cone electroretinograms (HP:0008323)1.80574789
160Autoamputation (HP:0001218)1.80060323
161Hypoplastic left heart (HP:0004383)1.79342574
162Ureteral duplication (HP:0000073)1.78625215
163Malignant hyperthermia (HP:0002047)1.77636352
164Septate vagina (HP:0001153)1.77614834
165Paraparesis (HP:0002385)1.76805825
166Sparse eyelashes (HP:0000653)1.76649854
167Rough bone trabeculation (HP:0100670)1.76424210
168Abnormal trabecular bone morphology (HP:0100671)1.75279322
169Abnormality of the pulmonary veins (HP:0011718)1.74623146
170Delayed gross motor development (HP:0002194)1.74414721
171Anencephaly (HP:0002323)1.74168167
172Multiple enchondromatosis (HP:0005701)1.74138756
173Sclerocornea (HP:0000647)1.73591344
174Increased neuronal autofluorescent lipopigment (HP:0002074)1.73437333
175Increased circulating renin level (HP:0000848)1.73257668
176Glycosuria (HP:0003076)1.73039066
177Abnormality of the fovea (HP:0000493)1.72164980
178Hip contracture (HP:0003273)1.72156847
179Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71906260
180Dicarboxylic aciduria (HP:0003215)1.71906260
181Congenital hepatic fibrosis (HP:0002612)1.71706467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.32913990
2OXSR13.56267705
3PHKG13.54526422
4PHKG23.54526422
5EPHB13.24057351
6MST43.13965653
7PBK2.88191341
8STK162.86105543
9BUB12.80779917
10MAP4K22.61510890
11VRK22.58827279
12FRK2.54790205
13BCR2.40519728
14MAPKAPK52.39217115
15EPHA22.31250206
16NME22.24519495
17MAPKAPK32.17830390
18MET2.12924265
19WNK41.98916452
20TNIK1.78602746
21MAPK131.76798010
22WNK31.76740985
23MAPK151.71821587
24TTN1.71189029
25AKT31.60398631
26ARAF1.59890158
27PKN11.54553626
28PIM21.52924968
29LIMK11.51325516
30ERBB31.49288581
31IRAK11.46331093
32MARK11.42015082
33IRAK31.41044209
34TRIM281.37568275
35MAP3K121.35638410
36TESK21.34361040
37NME11.24903993
38IRAK41.23286742
39NEK11.15436219
40NEK61.15270248
41IRAK21.14498320
42GRK71.13548872
43MYLK1.10408784
44CSNK1G11.09034573
45MAP2K21.07038426
46NUAK11.06889067
47CSNK1G31.05486405
48NLK1.04081079
49PNCK1.03887216
50CAMK2D1.03219717
51STK38L1.02286087
52EIF2AK31.02015784
53ROCK20.98671394
54TAOK30.98579934
55ADRBK10.97704100
56ZAK0.97626108
57TIE10.96237622
58CAMK2B0.96055179
59INSRR0.95299040
60BMPR1B0.94798816
61DYRK20.94601459
62MAP2K70.92426192
63TGFBR10.92253619
64MAP3K30.92076872
65WNK10.88409670
66CDK190.86860256
67TRPM70.85131449
68RPS6KA50.84567458
69STK240.84383493
70EPHA30.83561566
71CSNK1A1L0.82984547
72PRKCE0.82913925
73CDK30.81459864
74MAP3K40.79637087
75PTK2B0.79033222
76PIK3CA0.78908106
77BRSK20.78800000
78WEE10.78474327
79BMPR20.77094788
80ACVR1B0.75906746
81FGR0.74657622
82FGFR20.74304693
83CAMK2G0.72991799
84MST1R0.72244207
85TAF10.71493940
86PLK20.70379059
87TGFBR20.68973732
88PDK20.66319099
89PAK10.64924459
90PINK10.64352887
91TSSK60.63886948
92MUSK0.63280973
93DYRK30.62686552
94NTRK10.62625018
95GRK10.61107230
96CAMK2A0.61098781
97MKNK10.60314451
98IKBKB0.60201175
99STK30.59834257
100MAP2K60.59527491
101FER0.59329188
102MAP3K20.57560009
103OBSCN0.56563453
104ILK0.56380806
105PLK40.55503058
106SGK2230.54063162
107SGK4940.54063162
108TESK10.53582874
109CASK0.53053443
110CLK10.52486163
111LMTK20.51170198
112CCNB10.50412600
113ABL20.48232753
114VRK10.47574415
115PRKD10.47086016
116PRKACA0.46925686
117ADRBK20.46480850
118GSK3A0.45454600
119TXK0.45313795
120MAPKAPK20.44915117
121MAP2K10.43845009
122EIF2AK10.43795406
123ROCK10.43693837
124TLK10.43055953
125PIK3CG0.42240247
126PRKCG0.42148243
127UHMK10.40509275
128GRK50.40468533
129LRRK20.40367773
130DAPK20.39953145
131CSNK1G20.39360135
132CAMK10.39125518
133PAK30.38906144
134DAPK30.38343565
135MAP2K40.37536628
136MAP3K70.37476954
137PRKCQ0.36774009
138CSNK1A10.36235507
139DMPK0.36104333
140PRKG10.35809771
141EIF2AK20.35719575
142PRKAA20.35675523
143PRKAA10.34836122
144PRKCI0.34828646
145EPHB20.33204191
146BCKDK0.31487141
147PLK30.30901270
148RPS6KB20.30615381

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.67132538
2Steroid biosynthesis_Homo sapiens_hsa001004.29530804
3Fatty acid elongation_Homo sapiens_hsa000624.25085813
4Proteasome_Homo sapiens_hsa030503.48103779
5Protein export_Homo sapiens_hsa030603.28275871
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.07264871
7Oxidative phosphorylation_Homo sapiens_hsa001902.86503951
8RNA polymerase_Homo sapiens_hsa030202.48962576
9Sphingolipid metabolism_Homo sapiens_hsa006002.40517563
10Vitamin B6 metabolism_Homo sapiens_hsa007502.34025476
11Ether lipid metabolism_Homo sapiens_hsa005652.29621063
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.25310354
13Phototransduction_Homo sapiens_hsa047442.18248013
14Ribosome_Homo sapiens_hsa030102.14935058
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11156932
16Nitrogen metabolism_Homo sapiens_hsa009102.07873937
17Sulfur metabolism_Homo sapiens_hsa009202.02287832
18Parkinsons disease_Homo sapiens_hsa050121.97371369
19Dilated cardiomyopathy_Homo sapiens_hsa054141.76867800
20Regulation of autophagy_Homo sapiens_hsa041401.73616475
21Arachidonic acid metabolism_Homo sapiens_hsa005901.68713323
22Glutathione metabolism_Homo sapiens_hsa004801.67353132
23Linoleic acid metabolism_Homo sapiens_hsa005911.62736365
24Tryptophan metabolism_Homo sapiens_hsa003801.61199471
25Alzheimers disease_Homo sapiens_hsa050101.60690190
26Collecting duct acid secretion_Homo sapiens_hsa049661.57370156
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57238665
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.54118665
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52593006
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49975661
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47306443
32Histidine metabolism_Homo sapiens_hsa003401.46825108
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45174889
34Rheumatoid arthritis_Homo sapiens_hsa053231.42534012
35Lysosome_Homo sapiens_hsa041421.40093782
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39956148
37Vibrio cholerae infection_Homo sapiens_hsa051101.33401358
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31113311
39Huntingtons disease_Homo sapiens_hsa050161.29757188
40Circadian rhythm_Homo sapiens_hsa047101.29536001
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.27791442
42Selenocompound metabolism_Homo sapiens_hsa004501.09049924
43Folate biosynthesis_Homo sapiens_hsa007901.05333063
44RNA degradation_Homo sapiens_hsa030181.03873164
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00063578
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98358379
47Fatty acid metabolism_Homo sapiens_hsa012120.95205688
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94262899
49Butanoate metabolism_Homo sapiens_hsa006500.93995030
50Homologous recombination_Homo sapiens_hsa034400.93018711
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91410358
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90518565
53Pyruvate metabolism_Homo sapiens_hsa006200.90297081
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90073331
55Basal transcription factors_Homo sapiens_hsa030220.89837783
56Arginine and proline metabolism_Homo sapiens_hsa003300.88541755
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88331380
58Fatty acid degradation_Homo sapiens_hsa000710.87187949
59Mineral absorption_Homo sapiens_hsa049780.86421397
60Tight junction_Homo sapiens_hsa045300.85724088
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85717443
62Vitamin digestion and absorption_Homo sapiens_hsa049770.83385665
63Phagosome_Homo sapiens_hsa041450.83224428
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82811110
65Fanconi anemia pathway_Homo sapiens_hsa034600.82543631
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81962453
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.81218001
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80284096
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.78435516
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77605600
71Calcium signaling pathway_Homo sapiens_hsa040200.77017747
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71311532
73Metabolic pathways_Homo sapiens_hsa011000.69856029
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69525754
75Carbon metabolism_Homo sapiens_hsa012000.67504571
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67336518
77Autoimmune thyroid disease_Homo sapiens_hsa053200.67308506
78Peroxisome_Homo sapiens_hsa041460.63415858
79Olfactory transduction_Homo sapiens_hsa047400.62733511
80ECM-receptor interaction_Homo sapiens_hsa045120.62450769
81Other glycan degradation_Homo sapiens_hsa005110.60525630
82Pyrimidine metabolism_Homo sapiens_hsa002400.58373199
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56842164
84Ovarian steroidogenesis_Homo sapiens_hsa049130.56328710
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54570526
86Purine metabolism_Homo sapiens_hsa002300.53220703
87Starch and sucrose metabolism_Homo sapiens_hsa005000.52161197
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51914176
89Propanoate metabolism_Homo sapiens_hsa006400.51795755
90Oxytocin signaling pathway_Homo sapiens_hsa049210.51353357
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.50280131
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.49733103
93Chemical carcinogenesis_Homo sapiens_hsa052040.47583304
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47527003
95Taste transduction_Homo sapiens_hsa047420.45634372
96Nucleotide excision repair_Homo sapiens_hsa034200.45431526
97Retinol metabolism_Homo sapiens_hsa008300.45239232
98Axon guidance_Homo sapiens_hsa043600.44664910
99Cardiac muscle contraction_Homo sapiens_hsa042600.44052775
100Mismatch repair_Homo sapiens_hsa034300.42075699
101Circadian entrainment_Homo sapiens_hsa047130.41411313
102Salivary secretion_Homo sapiens_hsa049700.41363688
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.38157866
104Phenylalanine metabolism_Homo sapiens_hsa003600.37347685
105Renal cell carcinoma_Homo sapiens_hsa052110.37202668
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36110626
107Malaria_Homo sapiens_hsa051440.35719701
108Nicotine addiction_Homo sapiens_hsa050330.35443566
109Endocytosis_Homo sapiens_hsa041440.35160115
110Graft-versus-host disease_Homo sapiens_hsa053320.34276560
111Serotonergic synapse_Homo sapiens_hsa047260.33643715
112Pentose phosphate pathway_Homo sapiens_hsa000300.32303595
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32041062
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31859786
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31562160
116Tyrosine metabolism_Homo sapiens_hsa003500.31217715
117GABAergic synapse_Homo sapiens_hsa047270.30163005
118PPAR signaling pathway_Homo sapiens_hsa033200.28167712
119Caffeine metabolism_Homo sapiens_hsa002320.27386644
120Insulin secretion_Homo sapiens_hsa049110.27191580
121beta-Alanine metabolism_Homo sapiens_hsa004100.25751275
122Allograft rejection_Homo sapiens_hsa053300.25304510
123Asthma_Homo sapiens_hsa053100.23245593
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.20207783
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.19753078
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19688125
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19386900
128Pancreatic secretion_Homo sapiens_hsa049720.17912471
129Epstein-Barr virus infection_Homo sapiens_hsa051690.17226425
130Pertussis_Homo sapiens_hsa051330.15334363
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14346234
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13381722
133Hepatitis C_Homo sapiens_hsa051600.13104707
134Glycerolipid metabolism_Homo sapiens_hsa005610.11793692
135Shigellosis_Homo sapiens_hsa051310.11746202
136Renin-angiotensin system_Homo sapiens_hsa046140.11654723
137Ras signaling pathway_Homo sapiens_hsa040140.10782231
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10168340
139Prostate cancer_Homo sapiens_hsa052150.09682302
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09326936
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08465794
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07109541

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