TMEM160

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.77066027
2ribosomal small subunit assembly (GO:0000028)7.13709531
3viral transcription (GO:0019083)6.50211615
4translational termination (GO:0006415)6.24603487
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.72119204
6ribosomal small subunit biogenesis (GO:0042274)5.68435406
7protein targeting to ER (GO:0045047)5.59483330
8cotranslational protein targeting to membrane (GO:0006613)5.56394158
9translational elongation (GO:0006414)5.51060001
10protein localization to endoplasmic reticulum (GO:0070972)5.33970318
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.30929111
12viral life cycle (GO:0019058)4.90024751
13maturation of SSU-rRNA (GO:0030490)4.84424178
14purine deoxyribonucleotide catabolic process (GO:0009155)4.82729387
15base-excision repair, AP site formation (GO:0006285)4.78778773
16cellular protein complex disassembly (GO:0043624)4.74177200
17GTP biosynthetic process (GO:0006183)4.73402665
18deoxyribonucleotide catabolic process (GO:0009264)4.73117680
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.67847748
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67649761
21pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.62506368
22translational initiation (GO:0006413)4.61655456
23deoxyribose phosphate biosynthetic process (GO:0046385)4.59381601
242-deoxyribonucleotide biosynthetic process (GO:0009265)4.59381601
25deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.46720806
26pyrimidine nucleotide catabolic process (GO:0006244)4.36181994
27deoxyribose phosphate catabolic process (GO:0046386)4.30034444
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.27623473
29UTP biosynthetic process (GO:0006228)4.24818636
30telomere maintenance via semi-conservative replication (GO:0032201)4.11858969
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.11681307
32NADH dehydrogenase complex assembly (GO:0010257)4.11681307
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.11681307
34chaperone-mediated protein transport (GO:0072321)4.11258608
35protein complex disassembly (GO:0043241)4.10523335
362-deoxyribonucleotide metabolic process (GO:0009394)4.10132845
37pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.07285615
38UTP metabolic process (GO:0046051)3.94629813
39antigen processing and presentation via MHC class Ib (GO:0002475)3.92217408
40translation (GO:0006412)3.89579977
41macromolecular complex disassembly (GO:0032984)3.88182117
42DNA strand elongation involved in DNA replication (GO:0006271)3.86803260
43guanosine-containing compound biosynthetic process (GO:1901070)3.86351916
44negative regulation of B cell apoptotic process (GO:0002903)3.84862167
45ribosomal large subunit biogenesis (GO:0042273)3.78268056
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77820321
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.77820321
48protein targeting to membrane (GO:0006612)3.75361246
49pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.73867168
50mitochondrial calcium ion transport (GO:0006851)3.73630451
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.71418766
52deoxyribose phosphate metabolic process (GO:0019692)3.71195396
53DNA strand elongation (GO:0022616)3.70872345
54purine deoxyribonucleotide metabolic process (GO:0009151)3.67579357
55mature B cell differentiation involved in immune response (GO:0002313)3.65542222
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.61750264
57positive regulation of prostaglandin secretion (GO:0032308)3.60712562
58ribonucleoprotein complex biogenesis (GO:0022613)3.53800067
59CTP metabolic process (GO:0046036)3.52645619
60CTP biosynthetic process (GO:0006241)3.52645619
61oxidative phosphorylation (GO:0006119)3.47761377
62ubiquinone biosynthetic process (GO:0006744)3.45506826
63nuclear-transcribed mRNA catabolic process (GO:0000956)3.39833308
64respiratory chain complex IV assembly (GO:0008535)3.39145714
65pseudouridine synthesis (GO:0001522)3.38513330
66formation of translation preinitiation complex (GO:0001731)3.29916363
67GDP-mannose metabolic process (GO:0019673)3.29373603
68telomere maintenance via recombination (GO:0000722)3.29230873
69response to interferon-beta (GO:0035456)3.29027204
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28537148
71pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.24265878
72deoxyribonucleotide metabolic process (GO:0009262)3.23578348
73post-embryonic morphogenesis (GO:0009886)3.23454263
74mRNA catabolic process (GO:0006402)3.23091529
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20690726
76purine nucleotide salvage (GO:0032261)3.20143967
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17301974
78antigen processing and presentation of endogenous antigen (GO:0019883)3.17259261
79proteasome assembly (GO:0043248)3.16883319
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.16060417
81DNA replication initiation (GO:0006270)3.15428580
82iron-sulfur cluster assembly (GO:0016226)3.13897106
83metallo-sulfur cluster assembly (GO:0031163)3.13897106
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13065293
85protein targeting to mitochondrion (GO:0006626)3.12279516
86mucosal-associated lymphoid tissue development (GO:0048537)3.12197146
87Peyers patch development (GO:0048541)3.12197146
88purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10786636
89establishment of protein localization to mitochondrion (GO:0072655)3.09560982
90pyrimidine nucleotide biosynthetic process (GO:0006221)3.08262682
91RNA catabolic process (GO:0006401)3.07865774
92pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.07313733
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06909181
94cellular component biogenesis (GO:0044085)3.05462150
95antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.05350581
96grooming behavior (GO:0007625)3.03264209
97purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.98882016
98pentose-phosphate shunt (GO:0006098)2.97942310
99cytochrome complex assembly (GO:0017004)2.97856374
100energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97361655
101ATP synthesis coupled proton transport (GO:0015986)2.97361655
102ubiquinone metabolic process (GO:0006743)2.96378571
103mannosylation (GO:0097502)2.94178462
104heme biosynthetic process (GO:0006783)2.92718231
105rRNA processing (GO:0006364)2.92365084
106pteridine-containing compound biosynthetic process (GO:0042559)2.92228717
107pyrimidine nucleotide metabolic process (GO:0006220)2.90662356
108platelet dense granule organization (GO:0060155)2.89484685
109autophagic vacuole fusion (GO:0000046)2.89226381
110pyrimidine nucleoside biosynthetic process (GO:0046134)2.88489725
111telomere maintenance via telomere lengthening (GO:0010833)2.87756761
112RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86487697
113tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86487697
114Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86460386
115ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86090223
116negative regulation of JAK-STAT cascade (GO:0046426)2.83466037
117regulation of mitochondrial translation (GO:0070129)2.82046844
118mitotic recombination (GO:0006312)2.81451689
119negative regulation of myeloid cell apoptotic process (GO:0033033)2.81277199
120regulation of prostaglandin secretion (GO:0032306)2.80886357
121negative regulation of telomere maintenance (GO:0032205)2.80648651
122protein localization to mitochondrion (GO:0070585)2.79901824
123rRNA metabolic process (GO:0016072)2.77668848
124immunoglobulin mediated immune response (GO:0016064)2.74784661
125negative regulation of RNA splicing (GO:0033119)2.73737854
126phosphatidylglycerol biosynthetic process (GO:0006655)2.73539542
127deoxyribonucleotide biosynthetic process (GO:0009263)2.71623893
128negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.71553115
129ncRNA 3-end processing (GO:0043628)2.71223704
130nucleobase-containing small molecule interconversion (GO:0015949)2.70874597
131ribosome biogenesis (GO:0042254)2.70493481
132sequestering of actin monomers (GO:0042989)2.70157833
133regulation of protein heterodimerization activity (GO:0043497)2.69875158
134prostaglandin biosynthetic process (GO:0001516)2.68958238
135prostanoid biosynthetic process (GO:0046457)2.68958238
136peptidyl-arginine omega-N-methylation (GO:0035247)2.68073485
137ATP biosynthetic process (GO:0006754)2.68007018
138quinone biosynthetic process (GO:1901663)2.67319695
139pyrimidine-containing compound biosynthetic process (GO:0072528)2.67187751
140negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66869109
141negative regulation of mRNA processing (GO:0050686)2.66724462
142pentose metabolic process (GO:0019321)2.66256953
143galactose catabolic process (GO:0019388)2.65313830
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64942173
145nucleotide salvage (GO:0043173)2.64175460
146purine-containing compound salvage (GO:0043101)2.63993575
147pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63637950
148signal peptide processing (GO:0006465)2.63573805
149actin nucleation (GO:0045010)2.63428398
150establishment of protein localization to membrane (GO:0090150)2.62029556
151respiratory electron transport chain (GO:0022904)2.60026794
152nucleoside salvage (GO:0043174)2.59135377
153cellular response to interferon-beta (GO:0035458)2.58844995
154protein targeting (GO:0006605)2.58656202
155regulation of cellular amino acid metabolic process (GO:0006521)2.57180150
156DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.56989663
157electron transport chain (GO:0022900)2.54567940
158transcription elongation from RNA polymerase III promoter (GO:0006385)2.53380146
159termination of RNA polymerase III transcription (GO:0006386)2.53380146
160intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.52469419
161signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.52469419
162protein complex biogenesis (GO:0070271)2.51715829
163signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.51647821
164signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.51647821
165signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.51647821
166B cell mediated immunity (GO:0019724)2.51241182
167NADPH regeneration (GO:0006740)2.49983884
168positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49966146
169nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49919225
170positive regulation of B cell differentiation (GO:0045579)2.49665163
171mitochondrial respiratory chain complex assembly (GO:0033108)2.48611592
172spliceosomal snRNP assembly (GO:0000387)2.47097882
173negative regulation of erythrocyte differentiation (GO:0045647)2.46814403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.34008496
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.19940530
3E2F7_22180533_ChIP-Seq_HELA_Human4.01386651
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.62922686
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05204195
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83473434
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78955532
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.70150737
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69805109
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.54691806
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.54240535
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49270142
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.47667733
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46585677
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44976205
16TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.44387619
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.31728004
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.26328231
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19469467
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18395630
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09080744
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06009927
23VDR_21846776_ChIP-Seq_THP-1_Human2.05951797
24XRN2_22483619_ChIP-Seq_HELA_Human2.04135956
25MYC_22102868_ChIP-Seq_BL_Human2.03173344
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02249742
27VDR_23849224_ChIP-Seq_CD4+_Human2.01679403
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91279062
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.90095142
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86777446
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85575596
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83147518
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81626983
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78927196
35DCP1A_22483619_ChIP-Seq_HELA_Human1.78358538
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77447600
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.77320578
38P68_20966046_ChIP-Seq_HELA_Human1.76168852
39FOXP3_21729870_ChIP-Seq_TREG_Human1.75625084
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73837770
41* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72795186
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.71953201
43SCL_19346495_ChIP-Seq_HPC-7_Human1.71092481
44* SRF_21415370_ChIP-Seq_HL-1_Mouse1.69934871
45GABP_19822575_ChIP-Seq_HepG2_Human1.68881742
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68404585
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65536391
48LXR_22292898_ChIP-Seq_THP-1_Human1.64412469
49SPI1_23547873_ChIP-Seq_NB4_Human1.60886102
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.60272144
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59632663
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57039783
53* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53994140
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52727663
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51019144
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.50852471
57CIITA_25753668_ChIP-Seq_RAJI_Human1.50239329
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48756968
59TTF2_22483619_ChIP-Seq_HELA_Human1.44975547
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44483435
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.43249219
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43105736
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42816140
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.42736036
65BCOR_27268052_Chip-Seq_Bcells_Human1.42148376
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41030251
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40031845
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39679493
69E2F1_20622854_ChIP-Seq_HELA_Human1.39595232
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38645474
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38243132
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38055644
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35092933
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34578837
75PHF8_20622854_ChIP-Seq_HELA_Human1.33353080
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32454071
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32302270
78VDR_24763502_ChIP-Seq_THP-1_Human1.32282649
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31158623
80MAF_26560356_Chip-Seq_TH1_Human1.30126099
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.29561963
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28844749
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24668758
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23356562
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.23156597
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23049210
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21437706
88IRF8_21731497_ChIP-ChIP_J774_Mouse1.20149372
89KDM5A_27292631_Chip-Seq_BREAST_Human1.19911797
90UTX_26944678_Chip-Seq_JUKART_Human1.18152782
91CTCF_21964334_Chip-Seq_Bcells_Human1.17438696
92* CTCF_20526341_ChIP-Seq_ESCs_Human1.17289389
93MAF_26560356_Chip-Seq_TH2_Human1.16493867
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14688102
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13954613
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13814053
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13089121
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12145719
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11925219
100GATA1_22025678_ChIP-Seq_K562_Human1.11599167
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10787117
102P300_27268052_Chip-Seq_Bcells_Human1.10144446
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10134005
104SA1_27219007_Chip-Seq_Bcells_Human1.08941920
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07306359
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06863936
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06281892
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06241110
109MYB_26560356_Chip-Seq_TH2_Human1.05510358
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05347817
111CTCF_26484167_Chip-Seq_Bcells_Mouse1.05198665
112BCL6_27268052_Chip-Seq_Bcells_Human1.05031904
113BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04978903
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03560438
115* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03151493
116BP1_19119308_ChIP-ChIP_Hs578T_Human1.03077111
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02087820
118ETS1_21867929_ChIP-Seq_TH2_Mouse1.02005514
119MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01445506
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01017454
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00641898
122ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00159964
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00050855
124MYB_26560356_Chip-Seq_TH1_Human0.99687689
125CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99044741
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98857682
127PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98097235
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98054847
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97980601
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97950915
131ELK1_19687146_ChIP-ChIP_HELA_Human0.97828599
132ELK3_25401928_ChIP-Seq_HUVEC_Human0.97393518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.39711006
2MP0009379_abnormal_foot_pigmentation3.21867419
3MP0009278_abnormal_bone_marrow3.13361274
4MP0003693_abnormal_embryo_hatching3.04043566
5MP0009785_altered_susceptibility_to2.95978708
6MP0005645_abnormal_hypothalamus_physiol2.93251742
7MP0002396_abnormal_hematopoietic_system2.87730397
8MP0005671_abnormal_response_to2.82464406
9MP0002653_abnormal_ependyma_morphology2.78827281
10MP0000685_abnormal_immune_system2.78459033
11MP0003806_abnormal_nucleotide_metabolis2.48901095
12MP0005025_abnormal_response_to2.37702629
13MP0003763_abnormal_thymus_physiology2.32170126
14MP0009333_abnormal_splenocyte_physiolog2.31042793
15MP0003436_decreased_susceptibility_to2.30899910
16MP0000490_abnormal_crypts_of2.19859577
17MP0002234_abnormal_pharynx_morphology2.15698601
18MP0001853_heart_inflammation2.11866294
19MP0002398_abnormal_bone_marrow2.11834782
20MP0005000_abnormal_immune_tolerance2.10431794
21MP0001905_abnormal_dopamine_level2.03925863
22MP0006036_abnormal_mitochondrial_physio2.03188225
23MP0001800_abnormal_humoral_immune2.02315418
24MP0002148_abnormal_hypersensitivity_rea2.02203691
25MP0002822_catalepsy2.01257282
26MP0004957_abnormal_blastocyst_morpholog2.00850836
27MP0005174_abnormal_tail_pigmentation2.00026338
28MP0003724_increased_susceptibility_to1.99561374
29MP0002723_abnormal_immune_serum1.99169201
30MP0002420_abnormal_adaptive_immunity1.99021835
31MP0008789_abnormal_olfactory_epithelium1.95785532
32MP0001819_abnormal_immune_cell1.95433956
33MP0003186_abnormal_redox_activity1.92310663
34MP0000689_abnormal_spleen_morphology1.91514580
35MP0002452_abnormal_antigen_presenting1.89383022
36MP0005075_abnormal_melanosome_morpholog1.89071079
37MP0001873_stomach_inflammation1.87256467
38MP0002722_abnormal_immune_system1.83375679
39MP0000716_abnormal_immune_system1.83242384
40MP0005394_taste/olfaction_phenotype1.83101433
41MP0005499_abnormal_olfactory_system1.83101433
42MP0001545_abnormal_hematopoietic_system1.81465608
43MP0005397_hematopoietic_system_phenotyp1.81465608
44MP0006292_abnormal_olfactory_placode1.78898780
45MP0002429_abnormal_blood_cell1.77596918
46MP0002736_abnormal_nociception_after1.76975723
47MP0001968_abnormal_touch/_nociception1.76058549
48MP0005464_abnormal_platelet_physiology1.72504332
49MP0002163_abnormal_gland_morphology1.69074689
50MP0002419_abnormal_innate_immunity1.67801077
51MP0003646_muscle_fatigue1.63886064
52MP0010155_abnormal_intestine_physiology1.63437621
53MP0002166_altered_tumor_susceptibility1.63094003
54MP0002405_respiratory_system_inflammati1.61069071
55MP0003656_abnormal_erythrocyte_physiolo1.59318811
56MP0006276_abnormal_autonomic_nervous1.57523814
57MP0005646_abnormal_pituitary_gland1.57363852
58MP0003866_abnormal_defecation1.52127091
59MP0001790_abnormal_immune_system1.51216581
60MP0005387_immune_system_phenotype1.51216581
61MP0008469_abnormal_protein_level1.50802464
62MP0003077_abnormal_cell_cycle1.50628105
63MP0000858_altered_metastatic_potential1.49321936
64MP0004808_abnormal_hematopoietic_stem1.47667540
65MP0001845_abnormal_inflammatory_respons1.46553584
66MP0000343_altered_response_to1.44765609
67MP0008007_abnormal_cellular_replicative1.43723171
68MP0000703_abnormal_thymus_morphology1.39831177
69MP0002019_abnormal_tumor_incidence1.38078750
70MP0009840_abnormal_foam_cell1.33428277
71MP0003880_abnormal_central_pattern1.32503551
72MP0001529_abnormal_vocalization1.31617774
73MP0004858_abnormal_nervous_system1.31565359
74MP0002006_tumorigenesis1.31553269
75MP0010094_abnormal_chromosome_stability1.30698150
76MP0005083_abnormal_biliary_tract1.27683293
77MP0003111_abnormal_nucleus_morphology1.25184178
78MP0004147_increased_porphyrin_level1.24973585
79MP0008058_abnormal_DNA_repair1.22834511
80MP0004510_myositis1.20476563
81MP0004859_abnormal_synaptic_plasticity1.20460999
82MP0006035_abnormal_mitochondrial_morpho1.15799308
83MP0003787_abnormal_imprinting1.14711578
84MP0000465_gastrointestinal_hemorrhage1.13233642
85MP0002132_abnormal_respiratory_system1.12134513
86MP0002733_abnormal_thermal_nociception1.11323200
87MP0002095_abnormal_skin_pigmentation1.09706935
88MP0000313_abnormal_cell_death1.09261133
89MP0002160_abnormal_reproductive_system1.08038856
90MP0000681_abnormal_thyroid_gland1.06032326
91MP0001348_abnormal_lacrimal_gland1.05845838
92MP0000358_abnormal_cell_content/1.03208630
93MP0001663_abnormal_digestive_system1.02970842
94MP0005058_abnormal_lysosome_morphology1.02794026
95MP0002933_joint_inflammation1.01520049
96MP0004947_skin_inflammation1.01000393
97MP0005410_abnormal_fertilization1.00796267
98MP0006054_spinal_hemorrhage1.00494466
99MP0008872_abnormal_physiological_respon1.00335275
100MP0009764_decreased_sensitivity_to1.00273620
101MP0005319_abnormal_enzyme/_coenzyme0.99255128
102MP0010352_gastrointestinal_tract_polyps0.98941390
103MP0009046_muscle_twitch0.98212148
104MP0008932_abnormal_embryonic_tissue0.97978101
105MP0005379_endocrine/exocrine_gland_phen0.97968015
106MP0003191_abnormal_cellular_cholesterol0.95939236
107MP0005084_abnormal_gallbladder_morpholo0.94884436
108MP0003075_altered_response_to0.93409922
109MP0003828_pulmonary_edema0.93184739
110MP0002102_abnormal_ear_morphology0.93149535
111MP0005451_abnormal_body_composition0.92661576
112MP0004145_abnormal_muscle_electrophysio0.91175437
113MP0005636_abnormal_mineral_homeostasis0.90507918
114MP0002735_abnormal_chemical_nociception0.90425657
115MP0003011_delayed_dark_adaptation0.88499636
116MP0008873_increased_physiological_sensi0.88415842
117MP0004742_abnormal_vestibular_system0.87277527
118MP0000015_abnormal_ear_pigmentation0.86889690
119MP0003303_peritoneal_inflammation0.86535815
120MP0000750_abnormal_muscle_regeneration0.85574577
121MP0001542_abnormal_bone_strength0.85447653
122MP0006082_CNS_inflammation0.84481018
123MP0001970_abnormal_pain_threshold0.83907425
124MP0005389_reproductive_system_phenotype0.83244206
125MP0001764_abnormal_homeostasis0.82151917
126MP0005670_abnormal_white_adipose0.81849879
127MP0005584_abnormal_enzyme/coenzyme_acti0.81445411
128MP0000749_muscle_degeneration0.81149417
129MP0001533_abnormal_skeleton_physiology0.80664105
130MP0002638_abnormal_pupillary_reflex0.80614751
131MP0000372_irregular_coat_pigmentation0.79744731
132MP0003121_genomic_imprinting0.79495763
133MP0003221_abnormal_cardiomyocyte_apopto0.79314474
134MP0009763_increased_sensitivity_to0.79216890
135MP0001881_abnormal_mammary_gland0.79213830
136MP0009745_abnormal_behavioral_response0.78658929
137MP0000598_abnormal_liver_morphology0.78180741
138MP0009765_abnormal_xenobiotic_induced0.77554161
139MP0005330_cardiomyopathy0.77485395
140MP0009643_abnormal_urine_homeostasis0.77125345
141MP0000477_abnormal_intestine_morphology0.77062264
142MP0005220_abnormal_exocrine_pancreas0.74697814
143MP0001666_abnormal_nutrient_absorption0.73720383
144MP0001986_abnormal_taste_sensitivity0.72505009
145MP0003786_premature_aging0.71592309

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.35211263
2Abnormal number of erythroid precursors (HP:0012131)5.25529190
3Aplastic anemia (HP:0001915)4.49291113
4Reticulocytopenia (HP:0001896)4.36138687
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.09688312
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.09688312
7Elevated erythrocyte sedimentation rate (HP:0003565)4.05068791
8Reduced antithrombin III activity (HP:0001976)4.00933931
9Thrombocytosis (HP:0001894)3.93501890
10Type I transferrin isoform profile (HP:0003642)3.92910373
11Hepatocellular necrosis (HP:0001404)3.87139463
12Hepatic necrosis (HP:0002605)3.78947277
13IgM deficiency (HP:0002850)3.58480253
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.45535541
15Increased intramyocellular lipid droplets (HP:0012240)3.38790130
16Macrocytic anemia (HP:0001972)3.38460412
17Mitochondrial inheritance (HP:0001427)3.37817571
18Pallor (HP:0000980)3.37018824
19Petechiae (HP:0000967)3.35952364
20Abnormal protein glycosylation (HP:0012346)3.20752203
21Abnormal glycosylation (HP:0012345)3.20752203
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.20752203
23Abnormal protein N-linked glycosylation (HP:0012347)3.20752203
24Failure to thrive in infancy (HP:0001531)3.14321215
25Increased muscle lipid content (HP:0009058)3.14015952
26Abnormal mitochondria in muscle tissue (HP:0008316)3.12973312
27Acute necrotizing encephalopathy (HP:0006965)3.07632539
28Increased hepatocellular lipid droplets (HP:0006565)3.05032794
29Retinal dysplasia (HP:0007973)3.04190336
30Increased CSF lactate (HP:0002490)3.03548239
31Progressive muscle weakness (HP:0003323)3.03456022
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.02830208
33Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97030949
34Progressive microcephaly (HP:0000253)2.93300126
35Lipid accumulation in hepatocytes (HP:0006561)2.87237130
36Increased serum lactate (HP:0002151)2.81424007
37Exertional dyspnea (HP:0002875)2.81258273
38Abnormality of T cell physiology (HP:0011840)2.81230276
39Microretrognathia (HP:0000308)2.78471263
40Obstructive lung disease (HP:0006536)2.73898301
41Chronic obstructive pulmonary disease (HP:0006510)2.73898301
42Chronic otitis media (HP:0000389)2.73487550
43Recurrent bronchitis (HP:0002837)2.70706607
44Lactic acidosis (HP:0003128)2.68517821
45Myositis (HP:0100614)2.68388434
46Acute encephalopathy (HP:0006846)2.64404708
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.64120289
48Abnormality of the prostate (HP:0008775)2.56766837
493-Methylglutaconic aciduria (HP:0003535)2.52586545
50Oral leukoplakia (HP:0002745)2.52029579
51Cerebral palsy (HP:0100021)2.49950483
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49158401
53Multiple enchondromatosis (HP:0005701)2.48855111
54Exercise intolerance (HP:0003546)2.47964125
55Renal Fanconi syndrome (HP:0001994)2.44668273
56Ragged-red muscle fibers (HP:0003200)2.40506216
57Vacuolated lymphocytes (HP:0001922)2.39014880
58Agammaglobulinemia (HP:0004432)2.38325027
59Type II lissencephaly (HP:0007260)2.38164971
60Recurrent abscess formation (HP:0002722)2.38072260
61Pancytopenia (HP:0001876)2.34791018
62Visual hallucinations (HP:0002367)2.32430107
63Increased IgM level (HP:0003496)2.26479423
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25503365
65Myokymia (HP:0002411)2.22657876
66Abnormality of macrophages (HP:0004311)2.21267310
67Prolonged bleeding time (HP:0003010)2.21053707
68Progressive macrocephaly (HP:0004481)2.19592305
69IgG deficiency (HP:0004315)2.19483821
70Optic disc pallor (HP:0000543)2.18190637
71Hyperglycinemia (HP:0002154)2.16839195
72Abnormality of the nasal mucosa (HP:0000433)2.16629135
73Abnormality of T cells (HP:0002843)2.16247629
74Respiratory failure (HP:0002878)2.15712960
75Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15258443
76Increased serum ferritin (HP:0003281)2.15012334
77Microcytic anemia (HP:0001935)2.13383448
78Poor head control (HP:0002421)2.13065219
79Generalized aminoaciduria (HP:0002909)2.12101005
80Eczematoid dermatitis (HP:0000976)2.11585869
81Dicarboxylic aciduria (HP:0003215)2.10227995
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10227995
83Cerebral hypomyelination (HP:0006808)2.06260529
84Poikiloderma (HP:0001029)2.04165716
85Abnormality of renal resorption (HP:0011038)2.03481657
86Gliosis (HP:0002171)2.03436132
87Lethargy (HP:0001254)2.03249410
88Respiratory difficulties (HP:0002880)2.03165823
89Prostate neoplasm (HP:0100787)2.02996765
90Nasal polyposis (HP:0100582)2.01922525
91Severe global developmental delay (HP:0011344)2.01237309
92Cerebral edema (HP:0002181)2.00976859
93Abnormal platelet function (HP:0011869)2.00946175
94Impaired platelet aggregation (HP:0003540)2.00946175
95Abnormality of reticulocytes (HP:0004312)2.00843539
96Retinal atrophy (HP:0001105)2.00840158
97Abnormality of B cell number (HP:0010975)1.99778518
98B lymphocytopenia (HP:0010976)1.99778518
99Muscle fiber atrophy (HP:0100295)1.99461228
100CNS demyelination (HP:0007305)1.99110517
101Hypoplasia of the pons (HP:0012110)1.99075729
102Epistaxis (HP:0000421)1.99036256
103Recurrent bacterial skin infections (HP:0005406)1.99003340
104Panhypogammaglobulinemia (HP:0003139)1.98802199
105Interstitial pulmonary disease (HP:0006530)1.94663037
106Testicular atrophy (HP:0000029)1.94511626
107Recurrent fungal infections (HP:0002841)1.94256891
108Severe visual impairment (HP:0001141)1.93419641
109Severe combined immunodeficiency (HP:0004430)1.93150164
110Gastrointestinal stroma tumor (HP:0100723)1.92923160
111Hypertensive crisis (HP:0100735)1.92828053
112Lymphoma (HP:0002665)1.92666001
113Meningitis (HP:0001287)1.92040655
114Leukodystrophy (HP:0002415)1.87026326
115Polyphagia (HP:0002591)1.86998842
116Hypoproteinemia (HP:0003075)1.85486799
117Recurrent viral infections (HP:0004429)1.85305235
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84796947
119Abnormality of alanine metabolism (HP:0010916)1.84796947
120Hyperalaninemia (HP:0003348)1.84796947
121Recurrent cutaneous fungal infections (HP:0011370)1.83943874
122Chronic mucocutaneous candidiasis (HP:0002728)1.83943874
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.82967973
124Increased neuronal autofluorescent lipopigment (HP:0002074)1.82221467
125Microvesicular hepatic steatosis (HP:0001414)1.81173792
126Lymphopenia (HP:0001888)1.80353273
127Nausea (HP:0002018)1.79988366
128Beaking of vertebral bodies (HP:0004568)1.78809595
129Abnormal rod and cone electroretinograms (HP:0008323)1.78767790
130Amyotrophic lateral sclerosis (HP:0007354)1.77711223
131Emotional lability (HP:0000712)1.77440552
132Recurrent skin infections (HP:0001581)1.77174113
133Rhabdomyolysis (HP:0003201)1.75909096
134Mediastinal lymphadenopathy (HP:0100721)1.75856711
135Hepatosplenomegaly (HP:0001433)1.73384563
136Opisthotonus (HP:0002179)1.72962400
137Neutropenia (HP:0001875)1.72051918
138Abolished electroretinogram (ERG) (HP:0000550)1.69478829
139Abnormality of the pons (HP:0007361)1.68939447
140Stomatitis (HP:0010280)1.68542331
141Skin rash (HP:0000988)1.66750980
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.66722769
143Granulocytopenia (HP:0001913)1.65456606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.75442634
2VRK23.83155161
3MAP4K13.00250089
4STK162.98676668
5BCKDK2.82281717
6FLT32.71710649
7EIF2AK32.56538899
8KDR2.50262484
9PIM22.48309376
10TESK22.44309417
11KIT2.21982160
12WEE12.17641921
13BUB12.06743593
14MAP4K22.00504787
15ERN12.00395962
16SCYL21.91912657
17TBK11.89856890
18MAP3K111.88830849
19TEC1.81573690
20CDK191.81375738
21EIF2AK11.76483109
22BLK1.69603494
23LIMK11.60155800
24IRAK41.58142376
25ZAP701.57080418
26PKN21.51181663
27MAPKAPK31.45523473
28MUSK1.43144052
29IRAK31.41459380
30BTK1.41325395
31TNIK1.39093296
32VRK11.38701625
33LRRK21.38190508
34TLK11.35755184
35CSNK1G31.34321575
36TYK21.33197402
37MAP3K121.31273263
38TAOK31.30671519
39ARAF1.30237725
40ACVR1B1.27781382
41MAP2K71.23308874
42MAP2K31.22368273
43RPS6KB21.20918861
44IKBKE1.19009384
45ZAK1.18330681
46CSF1R1.15735065
47SYK1.11852551
48CAMKK21.08753159
49DYRK31.08180372
50ADRBK21.05024829
51TGFBR11.04000110
52EEF2K1.03178942
53JAK31.02009775
54DYRK21.00189248
55MYLK0.99608842
56CSNK1G20.99346047
57TIE10.96878986
58CSNK1A1L0.94355282
59CDC70.93443915
60RPS6KA40.91888671
61ILK0.91020941
62TXK0.89806205
63GRK60.89244997
64TESK10.87750615
65MATK0.86618417
66RPS6KA50.84788133
67DAPK30.81980957
68RAF10.81939936
69LYN0.80786690
70NLK0.80702800
71TRIB30.78752257
72NEK10.78285424
73GRK50.76885154
74IKBKB0.74944288
75NEK20.73303212
76FES0.73060604
77CDK70.71722172
78ABL20.71331391
79CSNK1G10.70235807
80PRKG20.69694783
81NME10.69179236
82BRAF0.68752178
83NUAK10.68217358
84MAP3K100.67715425
85MAP3K80.66632694
86LCK0.63913842
87PIM10.63291546
88MAP2K20.62521844
89SMG10.61858938
90MAP2K60.58872947
91GRK10.58621041
92CHEK20.53430263
93BRSK20.52245990
94CAMK2G0.52211833
95CAMK2B0.51927904
96CDK140.51768948
97PRKCI0.51551708
98RIPK40.51058857
99CDK80.50823112
100MAP3K10.49770162
101RPS6KL10.48957851
102RPS6KC10.48957851
103AURKB0.48930291
104TGFBR20.48876383
105MAPK110.48703098
106PAK40.48448200
107GRK70.48239156
108RPS6KA60.46399446
109TNK20.45941457
110DYRK1B0.45648612
111DAPK10.45280767
112CDK11A0.44733733
113WNK40.44605642
114CDK40.44247926
115CAMK10.43604687
116MAPK130.42540734
117TAOK20.41004539
118PINK10.40917820
119AURKA0.40524811
120CDK150.40486281
121ATR0.39220606
122SRPK10.38059542
123TAOK10.37429203
124CDK180.37102907
125PLK10.35702451
126MARK30.35142765
127EIF2AK20.34779223
128PAK10.34545355
129MAPK40.34373941
130MAPKAPK50.34122270
131PRKCD0.33988259
132CSNK2A20.33580865
133CAMK2D0.32597881
134HCK0.32296433
135PRKCQ0.31684675
136PKN10.31659066
137CSNK2A10.31490238
138MAP3K40.30971829
139CCNB10.30721099

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.71649545
2DNA replication_Homo sapiens_hsa030304.33037311
3Proteasome_Homo sapiens_hsa030503.18150654
4Mismatch repair_Homo sapiens_hsa034302.85212972
5Pyrimidine metabolism_Homo sapiens_hsa002402.41733500
6Sulfur relay system_Homo sapiens_hsa041222.40360296
7Base excision repair_Homo sapiens_hsa034102.39749712
8Parkinsons disease_Homo sapiens_hsa050122.32066816
9Oxidative phosphorylation_Homo sapiens_hsa001902.31246315
10RNA polymerase_Homo sapiens_hsa030202.27188458
11Protein export_Homo sapiens_hsa030602.17896405
12Homologous recombination_Homo sapiens_hsa034402.11432468
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04031694
14Folate biosynthesis_Homo sapiens_hsa007902.02894021
15Primary immunodeficiency_Homo sapiens_hsa053401.93298622
16Spliceosome_Homo sapiens_hsa030401.82306633
17Nucleotide excision repair_Homo sapiens_hsa034201.78519248
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62174233
19Pentose phosphate pathway_Homo sapiens_hsa000301.59490606
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56530945
21Huntingtons disease_Homo sapiens_hsa050161.52363742
22Other glycan degradation_Homo sapiens_hsa005111.45112345
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44154162
24Fatty acid elongation_Homo sapiens_hsa000621.43177254
25Alzheimers disease_Homo sapiens_hsa050101.40379392
26N-Glycan biosynthesis_Homo sapiens_hsa005101.35633841
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35565729
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35090366
29Antigen processing and presentation_Homo sapiens_hsa046121.34557917
30One carbon pool by folate_Homo sapiens_hsa006701.34198331
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24739191
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21467097
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13757889
34Purine metabolism_Homo sapiens_hsa002301.09275605
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.06276209
36Synaptic vesicle cycle_Homo sapiens_hsa047211.05006059
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04747441
38Phototransduction_Homo sapiens_hsa047441.03842636
39Galactose metabolism_Homo sapiens_hsa000521.03578284
40Leishmaniasis_Homo sapiens_hsa051401.03372169
41Sulfur metabolism_Homo sapiens_hsa009201.01839696
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.97006682
43Autoimmune thyroid disease_Homo sapiens_hsa053200.94919888
44Graft-versus-host disease_Homo sapiens_hsa053320.94694090
45RNA transport_Homo sapiens_hsa030130.94218118
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93995863
47Carbon metabolism_Homo sapiens_hsa012000.93974946
48p53 signaling pathway_Homo sapiens_hsa041150.93393730
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.90781604
50Biosynthesis of amino acids_Homo sapiens_hsa012300.90227814
51Phenylalanine metabolism_Homo sapiens_hsa003600.89899494
52Non-homologous end-joining_Homo sapiens_hsa034500.88930756
53Herpes simplex infection_Homo sapiens_hsa051680.87964677
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85858196
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85605408
56Allograft rejection_Homo sapiens_hsa053300.84227573
57Hematopoietic cell lineage_Homo sapiens_hsa046400.82189045
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81707579
59Legionellosis_Homo sapiens_hsa051340.80840671
60Butanoate metabolism_Homo sapiens_hsa006500.80119671
61Measles_Homo sapiens_hsa051620.79888579
62Rheumatoid arthritis_Homo sapiens_hsa053230.79419026
63Selenocompound metabolism_Homo sapiens_hsa004500.78417492
64RNA degradation_Homo sapiens_hsa030180.76456456
65Fanconi anemia pathway_Homo sapiens_hsa034600.73141766
66Fructose and mannose metabolism_Homo sapiens_hsa000510.72065833
67Thyroid cancer_Homo sapiens_hsa052160.70833734
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.69716330
69Collecting duct acid secretion_Homo sapiens_hsa049660.69534907
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69299529
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68935877
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68200741
73Cell cycle_Homo sapiens_hsa041100.67519194
74Cardiac muscle contraction_Homo sapiens_hsa042600.67420419
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65825440
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.65428084
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63737473
78Tyrosine metabolism_Homo sapiens_hsa003500.62852002
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62814956
80Acute myeloid leukemia_Homo sapiens_hsa052210.62784705
81Glutathione metabolism_Homo sapiens_hsa004800.62326960
82Systemic lupus erythematosus_Homo sapiens_hsa053220.61606098
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61054243
84B cell receptor signaling pathway_Homo sapiens_hsa046620.60445005
85Epstein-Barr virus infection_Homo sapiens_hsa051690.59114859
86Type I diabetes mellitus_Homo sapiens_hsa049400.58302073
87Metabolic pathways_Homo sapiens_hsa011000.57616192
88Apoptosis_Homo sapiens_hsa042100.57327792
89Pertussis_Homo sapiens_hsa051330.55301770
90Salmonella infection_Homo sapiens_hsa051320.54916021
91Fatty acid metabolism_Homo sapiens_hsa012120.53356544
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52776245
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52225976
94Viral myocarditis_Homo sapiens_hsa054160.52143850
95Arachidonic acid metabolism_Homo sapiens_hsa005900.52026710
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51796123
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51429765
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51243064
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50479662
100Olfactory transduction_Homo sapiens_hsa047400.50190257
101Shigellosis_Homo sapiens_hsa051310.49379122
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.48628023
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46234753
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43160190
105Influenza A_Homo sapiens_hsa051640.43100774
106Basal transcription factors_Homo sapiens_hsa030220.40424327
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40388359
108Regulation of autophagy_Homo sapiens_hsa041400.39732403
109Malaria_Homo sapiens_hsa051440.38999510
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.38869992
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36782445
112Vibrio cholerae infection_Homo sapiens_hsa051100.36225293
113Ether lipid metabolism_Homo sapiens_hsa005650.36092066
114Vitamin B6 metabolism_Homo sapiens_hsa007500.34305788
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33985873
116Asthma_Homo sapiens_hsa053100.32750144
117Tuberculosis_Homo sapiens_hsa051520.31836601
118Hepatitis B_Homo sapiens_hsa051610.31833849
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29844830
120Peroxisome_Homo sapiens_hsa041460.29782665
121Lysosome_Homo sapiens_hsa041420.29540025
122Renin-angiotensin system_Homo sapiens_hsa046140.28914045
123Tryptophan metabolism_Homo sapiens_hsa003800.28763592
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26759147
125Osteoclast differentiation_Homo sapiens_hsa043800.26499401
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26043675
127Alcoholism_Homo sapiens_hsa050340.26039771
128Viral carcinogenesis_Homo sapiens_hsa052030.25521875
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25215212
130Phagosome_Homo sapiens_hsa041450.24927716
131Pyruvate metabolism_Homo sapiens_hsa006200.24779876
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24014319
133Fatty acid degradation_Homo sapiens_hsa000710.23894909
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23671251
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.23642357
136Arginine and proline metabolism_Homo sapiens_hsa003300.20979853

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