TMEM161A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.56029107
2muscle filament sliding (GO:0030049)5.95191159
3actin-myosin filament sliding (GO:0033275)5.95191159
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.48236602
5cardiac myofibril assembly (GO:0055003)5.42747866
6ATP synthesis coupled proton transport (GO:0015986)5.01427648
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.01427648
8myofibril assembly (GO:0030239)5.00587850
9ribosomal small subunit biogenesis (GO:0042274)4.92474375
10regulation of skeletal muscle contraction (GO:0014819)4.84268163
11creatine metabolic process (GO:0006600)4.80830433
12actin-mediated cell contraction (GO:0070252)4.76018913
13tricarboxylic acid cycle (GO:0006099)4.68437004
14regulation of actin filament-based movement (GO:1903115)4.55890195
15cardiac muscle contraction (GO:0060048)4.44764899
16plasma membrane repair (GO:0001778)4.37697292
17regulation of mitochondrial translation (GO:0070129)4.34767528
18L-serine metabolic process (GO:0006563)4.29075221
19proline biosynthetic process (GO:0006561)4.28766770
20oxidative phosphorylation (GO:0006119)4.26153792
21DNA strand elongation involved in DNA replication (GO:0006271)4.23585455
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.19804318
23peptidyl-arginine omega-N-methylation (GO:0035247)4.15233714
24DNA strand elongation (GO:0022616)4.11738586
25formation of translation preinitiation complex (GO:0001731)4.10505185
26cardiac muscle cell development (GO:0055013)4.07681241
27adult heart development (GO:0007512)4.07057450
28respiratory electron transport chain (GO:0022904)4.06789358
29heart trabecula formation (GO:0060347)4.06566287
30actomyosin structure organization (GO:0031032)4.04520217
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.01517647
32negative regulation of potassium ion transmembrane transport (GO:1901380)3.97239994
33electron transport chain (GO:0022900)3.95719496
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93718939
35telomere maintenance via semi-conservative replication (GO:0032201)3.92176035
36maturation of SSU-rRNA (GO:0030490)3.91595921
37cardiac muscle tissue morphogenesis (GO:0055008)3.87527035
38aspartate family amino acid catabolic process (GO:0009068)3.84775681
39regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.84771380
40response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.84206182
41cardiac cell development (GO:0055006)3.82395939
42ribosomal small subunit assembly (GO:0000028)3.82226821
43ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.76559401
44regulation of relaxation of muscle (GO:1901077)3.75980829
45regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.71410516
46protein maturation by protein folding (GO:0022417)3.68002321
47positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.67931692
48DNA unwinding involved in DNA replication (GO:0006268)3.67116395
49histone arginine methylation (GO:0034969)3.63516928
50striated muscle contraction (GO:0006941)3.61593314
51ribosomal large subunit biogenesis (GO:0042273)3.58747406
52ribonucleoprotein complex biogenesis (GO:0022613)3.56726320
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56715602
54muscle tissue morphogenesis (GO:0060415)3.54263978
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.48496851
56negative regulation of protein localization to cell surface (GO:2000009)3.44274049
57viral life cycle (GO:0019058)3.43985962
58lysine metabolic process (GO:0006553)3.41239429
59lysine catabolic process (GO:0006554)3.41239429
60regulation of the force of heart contraction (GO:0002026)3.40957439
61regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.38610457
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.37705415
63DNA replication checkpoint (GO:0000076)3.36783826
64nucleobase biosynthetic process (GO:0046112)3.34851994
65translational initiation (GO:0006413)3.34679800
66proteasome assembly (GO:0043248)3.34263037
67regulation of striated muscle contraction (GO:0006942)3.33953011
68regulation of cardiac muscle cell contraction (GO:0086004)3.33772199
69actin filament-based movement (GO:0030048)3.32649965
70peptidyl-arginine methylation (GO:0018216)3.32319723
71peptidyl-arginine N-methylation (GO:0035246)3.32319723
72tricarboxylic acid metabolic process (GO:0072350)3.31777296
73DNA replication initiation (GO:0006270)3.30627647
74purine nucleobase biosynthetic process (GO:0009113)3.29497394
75spliceosomal snRNP assembly (GO:0000387)3.25011708
76nucleobase-containing small molecule interconversion (GO:0015949)3.25003937
77proline metabolic process (GO:0006560)3.22803172
78cellular protein complex disassembly (GO:0043624)3.20342716
79heart contraction (GO:0060047)3.19470723
80heart process (GO:0003015)3.19470723
81ribosome biogenesis (GO:0042254)3.19229191
82mitotic chromosome condensation (GO:0007076)3.17881063
83pseudouridine synthesis (GO:0001522)3.15016028
84transcription from mitochondrial promoter (GO:0006390)3.14696548
85serine family amino acid biosynthetic process (GO:0009070)3.12077269
86NADH metabolic process (GO:0006734)3.11542013
87translation (GO:0006412)3.11218823
88folic acid metabolic process (GO:0046655)3.09565800
89chaperone-mediated protein transport (GO:0072321)3.09284492
90regulation of ATPase activity (GO:0043462)3.09017453
91regulation of ATP catabolic process (GO:1903289)3.09017453
92protein targeting to mitochondrion (GO:0006626)3.08541346
93mitochondrial fusion (GO:0008053)3.08243945
94ATP biosynthetic process (GO:0006754)3.07774779
95pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.05864385
96cellular component biogenesis (GO:0044085)3.04239619
97epithelial cell-cell adhesion (GO:0090136)3.03556779
982-oxoglutarate metabolic process (GO:0006103)3.03256160
99regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.02854892
100telomere maintenance via recombination (GO:0000722)3.02041984
101glycogen catabolic process (GO:0005980)3.01636593
1024-hydroxyproline metabolic process (GO:0019471)3.01069910
103guanosine-containing compound biosynthetic process (GO:1901070)2.99921011
104viral transcription (GO:0019083)2.99581529
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98467612
106protein complex disassembly (GO:0043241)2.97955583
107heme biosynthetic process (GO:0006783)2.97790403
108pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.97287673
109GDP-mannose metabolic process (GO:0019673)2.96296340
110establishment of integrated proviral latency (GO:0075713)2.96176989
111regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.95503181
112sarcoplasmic reticulum calcium ion transport (GO:0070296)2.95232622
113IMP biosynthetic process (GO:0006188)2.95020666
114negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.93219084
115pentose metabolic process (GO:0019321)2.93216587
116regulation of mammary gland epithelial cell proliferation (GO:0033599)2.92310204
117base-excision repair (GO:0006284)2.90638905
118regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.89891481
119fatty acid beta-oxidation (GO:0006635)2.89839601
120ventricular cardiac muscle cell action potential (GO:0086005)2.89199574
121rRNA processing (GO:0006364)2.89002751
122metallo-sulfur cluster assembly (GO:0031163)2.88699094
123iron-sulfur cluster assembly (GO:0016226)2.88699094
124negative regulation of ligase activity (GO:0051352)2.87909182
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87909182
126response to inactivity (GO:0014854)2.87663787
127establishment of protein localization to mitochondrion (GO:0072655)2.87355003
128regulation of sarcomere organization (GO:0060297)2.86442648
129mitotic sister chromatid segregation (GO:0000070)2.85963038
130pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84872786
131pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.84746034
132transcription-coupled nucleotide-excision repair (GO:0006283)2.83547251
133heterochromatin organization (GO:0070828)2.82907434
134oxaloacetate metabolic process (GO:0006107)2.82181578
135axon ensheathment in central nervous system (GO:0032291)2.82103922
136central nervous system myelination (GO:0022010)2.82103922
137pyrimidine nucleotide catabolic process (GO:0006244)2.81731913
138cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81556225
139base-excision repair, AP site formation (GO:0006285)2.81290633
140peptidyl-histidine modification (GO:0018202)2.81014849
141ncRNA 3-end processing (GO:0043628)2.80184556
142skeletal muscle contraction (GO:0003009)2.80132217
143response to mercury ion (GO:0046689)2.79758520
144anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79351853
145bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79087173
146macromolecular complex disassembly (GO:0032984)2.78921519
147translational termination (GO:0006415)2.78734091
148ubiquinone biosynthetic process (GO:0006744)2.76858530
149quinone biosynthetic process (GO:1901663)2.76858530
150mitotic metaphase plate congression (GO:0007080)2.76452052
151glucan catabolic process (GO:0009251)2.76181041
152short-chain fatty acid metabolic process (GO:0046459)2.76123259
153UTP biosynthetic process (GO:0006228)2.76042709
154response to muscle activity (GO:0014850)2.75646952
155tRNA aminoacylation for protein translation (GO:0006418)2.75394952
156muscle contraction (GO:0006936)2.74640688
157mitochondrial RNA metabolic process (GO:0000959)2.74185152
158regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73967247
159mitotic recombination (GO:0006312)2.72754123
160SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.72568221
161trabecula formation (GO:0060343)2.71617692
162regulation of translational termination (GO:0006449)2.71606419
163protein targeting to ER (GO:0045047)2.71551372
164rRNA metabolic process (GO:0016072)2.70652986
165Golgi transport vesicle coating (GO:0048200)2.70646327
166COPI coating of Golgi vesicle (GO:0048205)2.70646327
167cotranslational protein targeting to membrane (GO:0006613)2.70568499
168rRNA transcription (GO:0009303)2.69655275
169protein retention in ER lumen (GO:0006621)2.69072366
170protein localization to mitochondrion (GO:0070585)2.68768359
171cardiac muscle hypertrophy (GO:0003300)2.67870221
172acyl-CoA biosynthetic process (GO:0071616)2.67469233
173thioester biosynthetic process (GO:0035384)2.67469233
174establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67422513
175regulation of cell communication by electrical coupling (GO:0010649)2.63730886
176translational elongation (GO:0006414)2.62299584
177regulation of translational fidelity (GO:0006450)2.58912171
178striated muscle hypertrophy (GO:0014897)2.58459608
179succinate metabolic process (GO:0006105)2.57662350
180branched-chain amino acid catabolic process (GO:0009083)2.56331730
181regulation of membrane repolarization (GO:0060306)2.53671657
182protein localization to endoplasmic reticulum (GO:0070972)2.52998432
183striated muscle cell development (GO:0055002)2.52933019
184carnitine shuttle (GO:0006853)2.52009882
185cell communication by electrical coupling (GO:0010644)2.50752518
186regulation of cardiac muscle contraction (GO:0055117)2.50383075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.95573856
2E2F7_22180533_ChIP-Seq_HELA_Human4.25336017
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95470009
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66812011
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.62478945
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59980583
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.42456406
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.36787604
9CLOCK_20551151_ChIP-Seq_293T_Human2.33660091
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.25815300
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20918020
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.15841176
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13975848
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13614003
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09962330
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04838415
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.01367355
18MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.98468886
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98294771
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.93678543
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87432462
22LXR_22292898_ChIP-Seq_THP-1_Human1.82162526
23CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81472973
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76611045
25TBX20_22328084_ChIP-Seq_HEART_Mouse1.75739155
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.75739155
27TTF2_22483619_ChIP-Seq_HELA_Human1.71595403
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.70308652
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.69324371
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.68767915
31VDR_21846776_ChIP-Seq_THP-1_Human1.68620152
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67001708
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66573344
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65075187
35BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.63541360
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63473249
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.62932477
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61534181
39XRN2_22483619_ChIP-Seq_HELA_Human1.61525786
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60617466
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.59287719
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58108896
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.57817153
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56439867
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54523372
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53367573
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.50597348
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49800101
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49093251
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.48460579
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47792569
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46834286
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46287819
54GATA4_21415370_ChIP-Seq_HL-1_Mouse1.45439562
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45093533
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44938774
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.43948259
58RACK7_27058665_Chip-Seq_MCF-7_Human1.43391605
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42889023
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42139528
61KDM5A_27292631_Chip-Seq_BREAST_Human1.40686923
62ATF3_27146783_Chip-Seq_COLON_Human1.39578219
63ZNF263_19887448_ChIP-Seq_K562_Human1.38970789
64NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.38163085
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38057002
66FOXP3_21729870_ChIP-Seq_TREG_Human1.37971240
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.36902492
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36866104
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36412519
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35631700
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34422792
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31066384
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30640112
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30549479
75TBX5_21415370_ChIP-Seq_HL-1_Mouse1.30178277
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30120504
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.29962282
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29289224
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28637333
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27884372
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.27034759
82KDM2B_26808549_Chip-Seq_DND41_Human1.26827912
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26761337
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25275404
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23847580
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22770666
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22226798
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21463298
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20799320
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20786961
91* SA1_27219007_Chip-Seq_ERYTHROID_Human1.20414618
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19408353
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19398539
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19283766
95AR_21909140_ChIP-Seq_LNCAP_Human1.18553165
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18370202
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18215363
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17854002
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17824840
100DCP1A_22483619_ChIP-Seq_HELA_Human1.17484084
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17319025
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17243994
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16876563
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14461562
105ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14269077
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13810767
107ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13279454
108VDR_23849224_ChIP-Seq_CD4+_Human1.13229015
109SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12706117
110CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11968687
111* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11571158
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11504606
113P68_20966046_ChIP-Seq_HELA_Human1.10452271
114CIITA_25753668_ChIP-Seq_RAJI_Human1.10450011
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10323149
116CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09720094
117GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09718853
118* MYC_22102868_ChIP-Seq_BL_Human1.09694213
119FOXP1_21924763_ChIP-Seq_HESCs_Human1.09446996
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08666803
121RXR_22158963_ChIP-Seq_LIVER_Mouse1.07878384
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07776016
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.06439640
124GABP_19822575_ChIP-Seq_HepG2_Human1.06247085
125* CTCF_21964334_Chip-Seq_Bcells_Human1.04231724
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02977466
127GATA1_19941826_ChIP-Seq_K562_Human1.02690090
128HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01289287
129TP63_17297297_ChIP-ChIP_HaCaT_Human1.00965647
130CTCF_26484167_Chip-Seq_Bcells_Mouse1.00748055
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99664329
132CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99443178
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99348735
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98815044
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98420302
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98373646
137SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98033586
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97749427
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97044713
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96934327
141* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96628271
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95492085
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95422163
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.95142947
145CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94842881
146ELK1_22589737_ChIP-Seq_MCF10A_Human0.94824713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.84578374
2MP0000751_myopathy4.45970318
3MP0004084_abnormal_cardiac_muscle4.20280141
4MP0000749_muscle_degeneration4.01572859
5MP0003693_abnormal_embryo_hatching4.01444668
6MP0003111_abnormal_nucleus_morphology3.49751891
7MP0004036_abnormal_muscle_relaxation3.46894047
8MP0010094_abnormal_chromosome_stability3.35542708
9MP0005330_cardiomyopathy3.33469549
10MP0004215_abnormal_myocardial_fiber3.24567844
11MP0003646_muscle_fatigue3.10172330
12MP0008932_abnormal_embryonic_tissue2.98837882
13MP0004957_abnormal_blastocyst_morpholog2.98534320
14MP0000750_abnormal_muscle_regeneration2.90345805
15MP0003077_abnormal_cell_cycle2.75408089
16MP0003806_abnormal_nucleotide_metabolis2.73725010
17MP0004087_abnormal_muscle_fiber2.63743585
18MP0000747_muscle_weakness2.62013188
19MP0008058_abnormal_DNA_repair2.51984669
20MP0003950_abnormal_plasma_membrane2.47687279
21MP0005451_abnormal_body_composition2.42911346
22MP0008775_abnormal_heart_ventricle2.41262529
23MP0002269_muscular_atrophy2.40547322
24MP0004145_abnormal_muscle_electrophysio2.39365027
25MP0002106_abnormal_muscle_physiology2.33968738
26MP0005620_abnormal_muscle_contractility2.30825191
27MP0002972_abnormal_cardiac_muscle2.27684471
28MP0008438_abnormal_cutaneous_collagen2.25398107
29MP0002249_abnormal_larynx_morphology2.14903152
30MP0000759_abnormal_skeletal_muscle2.14197935
31MP0008007_abnormal_cellular_replicative2.12878529
32MP0000678_abnormal_parathyroid_gland2.10554102
33MP0006138_congestive_heart_failure2.08776418
34MP0008260_abnormal_autophagy2.03659901
35MP0005369_muscle_phenotype1.99862996
36MP0005385_cardiovascular_system_phenoty1.97895650
37MP0001544_abnormal_cardiovascular_syste1.97895650
38MP0010630_abnormal_cardiac_muscle1.95398133
39MP0003137_abnormal_impulse_conducting1.91083225
40MP0001730_embryonic_growth_arrest1.90717819
41MP0004147_increased_porphyrin_level1.88639090
42MP0003279_aneurysm1.87160357
43MP0003186_abnormal_redox_activity1.84875973
44MP0006036_abnormal_mitochondrial_physio1.79195627
45MP0004130_abnormal_muscle_cell1.78114182
46MP0004858_abnormal_nervous_system1.76804171
47MP0000566_synostosis1.76745354
48MP0003786_premature_aging1.76486330
49MP0003705_abnormal_hypodermis_morpholog1.75449037
50MP0004272_abnormal_basement_membrane1.74743593
51MP0003315_abnormal_perineum_morphology1.73558954
52MP0000350_abnormal_cell_proliferation1.71187636
53MP0003221_abnormal_cardiomyocyte_apopto1.68146313
54MP0000537_abnormal_urethra_morphology1.67893555
55MP0000049_abnormal_middle_ear1.63956109
56MP0001849_ear_inflammation1.59934781
57MP0003567_abnormal_fetal_cardiomyocyte1.55812951
58MP0006054_spinal_hemorrhage1.54534522
59MP0003828_pulmonary_edema1.53588914
60MP0002332_abnormal_exercise_endurance1.50581195
61MP0004043_abnormal_pH_regulation1.50548538
62MP0005501_abnormal_skin_physiology1.49300958
63MP0004233_abnormal_muscle_weight1.49197276
64MP0005666_abnormal_adipose_tissue1.48854922
65MP0005670_abnormal_white_adipose1.46426287
66MP0005623_abnormal_meninges_morphology1.44754069
67MP0001764_abnormal_homeostasis1.44218503
68MP0009697_abnormal_copulation1.43759538
69MP0002080_prenatal_lethality1.37821502
70MP0000313_abnormal_cell_death1.35256826
71MP0005380_embryogenesis_phenotype1.35059037
72MP0001672_abnormal_embryogenesis/_devel1.35059037
73MP0006292_abnormal_olfactory_placode1.33616663
74MP0009840_abnormal_foam_cell1.31020732
75MP0001697_abnormal_embryo_size1.29814448
76MP0004185_abnormal_adipocyte_glucose1.29631705
77MP0009780_abnormal_chondrocyte_physiolo1.29377952
78MP0003136_yellow_coat_color1.26435962
79MP0002796_impaired_skin_barrier1.25998192
80MP0003984_embryonic_growth_retardation1.25605409
81MP0009384_cardiac_valve_regurgitation1.23351062
82MP0003718_maternal_effect1.23135213
83MP0002938_white_spotting1.22603073
84MP0002127_abnormal_cardiovascular_syste1.21420547
85MP0001346_abnormal_lacrimal_gland1.21087845
86MP0005375_adipose_tissue_phenotype1.21061079
87MP0002697_abnormal_eye_size1.19860664
88MP0004085_abnormal_heartbeat1.17786502
89MP0005266_abnormal_metabolism1.17730694
90MP0002085_abnormal_embryonic_tissue1.17092010
91MP0000762_abnormal_tongue_morphology1.15613570
92MP0000013_abnormal_adipose_tissue1.15091485
93MP0002088_abnormal_embryonic_growth/wei1.15068699
94MP0002108_abnormal_muscle_morphology1.14306872
95MP0005165_increased_susceptibility_to1.13636032
96MP0003656_abnormal_erythrocyte_physiolo1.10268001
97MP0002254_reproductive_system_inflammat1.10232594
98MP0002234_abnormal_pharynx_morphology1.07502443
99MP0001661_extended_life_span1.07366989
100MP0003941_abnormal_skin_development1.06918456
101MP0004484_altered_response_of1.04713178
102MP0000733_abnormal_muscle_development1.03785100
103MP0000266_abnormal_heart_morphology1.03657055
104MP0002111_abnormal_tail_morphology1.01433020
105MP0009379_abnormal_foot_pigmentation0.98140793
106MP0009333_abnormal_splenocyte_physiolog0.97122895
107MP0000003_abnormal_adipose_tissue0.96359264
108MP0002132_abnormal_respiratory_system0.93591712
109MP0003329_amyloid_beta_deposits0.91187800
110MP0002092_abnormal_eye_morphology0.88841806
111MP0003566_abnormal_cell_adhesion0.88514248
112MP0006035_abnormal_mitochondrial_morpho0.87846889
113MP0003385_abnormal_body_wall0.87779347
114MP0000467_abnormal_esophagus_morphology0.85624274
115MP0005275_abnormal_skin_tensile0.83633271
116MP0002084_abnormal_developmental_patter0.81538526
117MP0005058_abnormal_lysosome_morphology0.81273549
118MP0002128_abnormal_blood_circulation0.80435919
119MP0003942_abnormal_urinary_system0.79292564
120MP0005503_abnormal_tendon_morphology0.78650019
121MP0002877_abnormal_melanocyte_morpholog0.78552819
122MP0000490_abnormal_crypts_of0.78190337
123MP0005360_urolithiasis0.78009892
124MP0001881_abnormal_mammary_gland0.77582258
125MP0004133_heterotaxia0.75371281
126MP0009250_abnormal_appendicular_skeleto0.74311965
127MP0000920_abnormal_myelination0.74222572
128MP0010307_abnormal_tumor_latency0.74181640
129MP0002295_abnormal_pulmonary_circulatio0.73777137
130MP0000681_abnormal_thyroid_gland0.73015606
131MP0002089_abnormal_postnatal_growth/wei0.72681297
132MP0001299_abnormal_eye_distance/0.72324227
133MP0001293_anophthalmia0.72294336
134MP0003122_maternal_imprinting0.72011833
135MP0005171_absent_coat_pigmentation0.71831615
136MP0000230_abnormal_systemic_arterial0.71784358
137MP0009053_abnormal_anal_canal0.71272777
138MP0005408_hypopigmentation0.71098999
139MP0002086_abnormal_extraembryonic_tissu0.70943134
140MP0001958_emphysema0.70019921
141MP0003937_abnormal_limbs/digits/tail_de0.69824783
142MP0002019_abnormal_tumor_incidence0.69390565
143MP0008789_abnormal_olfactory_epithelium0.69201922
144MP0003453_abnormal_keratinocyte_physiol0.69096006
145MP0005257_abnormal_intraocular_pressure0.68465936
146MP0003283_abnormal_digestive_organ0.66950250
147MP0010030_abnormal_orbit_morphology0.66541914
148MP0005595_abnormal_vascular_smooth0.66246836
149MP0000343_altered_response_to0.65041024
150MP0000358_abnormal_cell_content/0.63429063
151MP0001879_abnormal_lymphatic_vessel0.62529472
152MP0005083_abnormal_biliary_tract0.62418215
153MP0010368_abnormal_lymphatic_system0.60577518
154MP0002933_joint_inflammation0.58151730
155MP0003634_abnormal_glial_cell0.57789029
156MP0001614_abnormal_blood_vessel0.53840457
157MP0006072_abnormal_retinal_apoptosis0.53212563
158MP0009643_abnormal_urine_homeostasis0.52044404
159MP0009672_abnormal_birth_weight0.52010111
160MP0000767_abnormal_smooth_muscle0.51811026
161MP0000428_abnormal_craniofacial_morphol0.49225331
162MP0000462_abnormal_digestive_system0.48638184
163MP0002971_abnormal_brown_adipose0.47334526
164MP0005584_abnormal_enzyme/coenzyme_acti0.47235328
165MP0005332_abnormal_amino_acid0.44984877
166MP0001529_abnormal_vocalization0.44269931
167MP0002925_abnormal_cardiovascular_devel0.44230828
168MP0005023_abnormal_wound_healing0.43651595

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)5.01934629
2Exercise-induced myalgia (HP:0003738)4.90991396
3Sudden death (HP:0001699)4.88020688
4Muscle fiber splitting (HP:0003555)4.80992118
5Muscle hypertrophy of the lower extremities (HP:0008968)4.47236104
6Calf muscle hypertrophy (HP:0008981)4.43844052
7Myoglobinuria (HP:0002913)4.27052869
8Hyporeflexia of lower limbs (HP:0002600)4.19405016
9Ventricular tachycardia (HP:0004756)4.11868933
10Microvesicular hepatic steatosis (HP:0001414)4.08323264
11Abnormality of the calf musculature (HP:0001430)3.93872476
12Rhabdomyolysis (HP:0003201)3.67630901
13Lipoatrophy (HP:0100578)3.67437691
14EMG: myopathic abnormalities (HP:0003458)3.61199649
15Type 1 muscle fiber predominance (HP:0003803)3.53098612
16Reticulocytopenia (HP:0001896)3.37249491
17Increased connective tissue (HP:0009025)3.36678633
18Difficulty running (HP:0009046)3.35990122
19Broad distal phalanx of finger (HP:0009836)3.32613668
20Palpitations (HP:0001962)3.31400471
21Abnormality of the left ventricular outflow tract (HP:0011103)3.28624215
22Subaortic stenosis (HP:0001682)3.28624215
23Hepatic necrosis (HP:0002605)3.27900089
24Cholecystitis (HP:0001082)3.27724306
25Abnormal gallbladder physiology (HP:0012438)3.27724306
26Abnormal number of erythroid precursors (HP:0012131)3.27576045
27Asymmetric septal hypertrophy (HP:0001670)3.27125358
28Hepatocellular necrosis (HP:0001404)3.26466939
29Atrial fibrillation (HP:0005110)3.25971438
30Abnormality of cells of the erythroid lineage (HP:0012130)3.24993246
31Dilated cardiomyopathy (HP:0001644)3.20579960
32Muscle fiber inclusion bodies (HP:0100299)3.19398502
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.17383231
34Supraventricular arrhythmia (HP:0005115)3.11074558
35Supraventricular tachycardia (HP:0004755)3.10260204
36Primary atrial arrhythmia (HP:0001692)3.08954347
37Aplasia/Hypoplasia of the sacrum (HP:0008517)3.04417778
38Abnormal mitochondria in muscle tissue (HP:0008316)3.03120677
39Myotonia (HP:0002486)2.97041535
40Acute necrotizing encephalopathy (HP:0006965)2.96728254
41Round ear (HP:0100830)2.94613131
42Increased variability in muscle fiber diameter (HP:0003557)2.88310490
43Type I transferrin isoform profile (HP:0003642)2.85820985
44Acute encephalopathy (HP:0006846)2.84657568
45Broad metatarsal (HP:0001783)2.83040788
46Right ventricular cardiomyopathy (HP:0011663)2.73512238
47Abnormality of skeletal muscle fiber size (HP:0012084)2.72861573
48Diaphragmatic weakness (HP:0009113)2.70766704
49Mitochondrial inheritance (HP:0001427)2.68157289
50Muscle stiffness (HP:0003552)2.67782624
51Ragged-red muscle fibers (HP:0003200)2.66848993
52Abnormality of glycolysis (HP:0004366)2.61938665
53Increased serum pyruvate (HP:0003542)2.61938665
54Microretrognathia (HP:0000308)2.59101158
55Nemaline bodies (HP:0003798)2.56302412
56Difficulty climbing stairs (HP:0003551)2.55858824
57Selective tooth agenesis (HP:0001592)2.54824215
58Macrocytic anemia (HP:0001972)2.54561540
59Progressive muscle weakness (HP:0003323)2.54539195
60Gout (HP:0001997)2.50213574
61Abnormality of reticulocytes (HP:0004312)2.47777180
62Renal Fanconi syndrome (HP:0001994)2.44286354
63Protrusio acetabuli (HP:0003179)2.43309681
64Centrally nucleated skeletal muscle fibers (HP:0003687)2.43167973
65Neck muscle weakness (HP:0000467)2.42695608
66Increased CSF lactate (HP:0002490)2.42231675
67Increased hepatocellular lipid droplets (HP:0006565)2.41189515
68Large for gestational age (HP:0001520)2.40781403
69Ketoacidosis (HP:0001993)2.40208264
70Trismus (HP:0000211)2.39590108
71Prolonged QT interval (HP:0001657)2.39557388
72Increased muscle lipid content (HP:0009058)2.39190040
73Abnormality of the umbilical cord (HP:0010881)2.33404920
74Exercise intolerance (HP:0003546)2.32432303
75Lipid accumulation in hepatocytes (HP:0006561)2.32001215
76Hypokinesia (HP:0002375)2.31608979
77Ventricular arrhythmia (HP:0004308)2.31100545
78Rough bone trabeculation (HP:0100670)2.30744363
79Dicarboxylic aciduria (HP:0003215)2.29658571
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29658571
81Limb-girdle muscle atrophy (HP:0003797)2.28621811
82Respiratory failure (HP:0002878)2.27019010
83Increased intramyocellular lipid droplets (HP:0012240)2.25730466
84Abnormal protein glycosylation (HP:0012346)2.24560019
85Abnormal glycosylation (HP:0012345)2.24560019
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24560019
87Abnormal protein N-linked glycosylation (HP:0012347)2.24560019
88Mildly elevated creatine phosphokinase (HP:0008180)2.24324750
89Scapular winging (HP:0003691)2.24081848
90Breast hypoplasia (HP:0003187)2.21967961
91Syncope (HP:0001279)2.19207707
92Progressive macrocephaly (HP:0004481)2.19206557
93Reduced antithrombin III activity (HP:0001976)2.19185395
94Abnormal umbilical cord blood vessels (HP:0011403)2.16690141
95Single umbilical artery (HP:0001195)2.16690141
96Abnormality of the fetal cardiovascular system (HP:0010948)2.16690141
97Respiratory difficulties (HP:0002880)2.14477861
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14303306
99Mesangial abnormality (HP:0001966)2.13929461
100Distal arthrogryposis (HP:0005684)2.13741430
101Premature skin wrinkling (HP:0100678)2.13475288
102Testicular atrophy (HP:0000029)2.11909018
103Hypoglycemic coma (HP:0001325)2.11855455
104Truncus arteriosus (HP:0001660)2.11482006
105Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09863150
106Cerebral edema (HP:0002181)2.09673886
107Ketosis (HP:0001946)2.09287761
108Ulnar bowing (HP:0003031)2.08453680
109Muscular dystrophy (HP:0003560)2.07708266
110Generalized amyotrophy (HP:0003700)2.05736472
111Reticulocytosis (HP:0001923)2.05395559
112Myopathic facies (HP:0002058)2.05121195
113Birth length less than 3rd percentile (HP:0003561)2.05060939
114Lactic acidosis (HP:0003128)2.04970006
115Cholelithiasis (HP:0001081)2.04349312
116Abnormality of aromatic amino acid family metabolism (HP:0004338)2.00558759
117Hyperacusis (HP:0010780)1.99274786
118Gowers sign (HP:0003391)1.99078001
119Spinal rigidity (HP:0003306)1.98999870
120Abnormality of the Achilles tendon (HP:0005109)1.97459806
121Abnormality of cochlea (HP:0000375)1.94384462
122Opisthotonus (HP:0002179)1.93816402
123Stridor (HP:0010307)1.93053317
124Abnormality of the tricuspid valve (HP:0001702)1.89705561
125Nonimmune hydrops fetalis (HP:0001790)1.88705138
126Calcaneovalgus deformity (HP:0001848)1.88539270
127Ulnar deviation of the wrist (HP:0003049)1.88119900
128Pallor (HP:0000980)1.87317447
129Abnormality of serine family amino acid metabolism (HP:0010894)1.87076497
130Abnormality of glycine metabolism (HP:0010895)1.87076497
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86970790
132Absent epiphyses (HP:0010577)1.86970790
133Premature rupture of membranes (HP:0001788)1.86903679
134Generalized muscle weakness (HP:0003324)1.84493404
135Spastic paraparesis (HP:0002313)1.84372833
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82831999
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82831999
138Pheochromocytoma (HP:0002666)1.82484704
139Abnormal number of incisors (HP:0011064)1.82000606
140Methylmalonic aciduria (HP:0012120)1.81152618
141Spastic diplegia (HP:0001264)1.78784869
142Increased serum lactate (HP:0002151)1.78740595
143Secondary amenorrhea (HP:0000869)1.78442836
144Abnormality of the gallbladder (HP:0005264)1.77994199
145Neoplasm of the adrenal gland (HP:0100631)1.77247020
146Areflexia of lower limbs (HP:0002522)1.76507145
147Prolonged neonatal jaundice (HP:0006579)1.76196301
148Late onset (HP:0003584)1.75968043
149Distal lower limb muscle weakness (HP:0009053)1.75084441
150Cerebellar dysplasia (HP:0007033)1.75008313
151Abnormalities of placenta or umbilical cord (HP:0001194)1.73854716
152Neuroendocrine neoplasm (HP:0100634)1.73753484
153Multiple enchondromatosis (HP:0005701)1.73367494
154Abnormal gallbladder morphology (HP:0012437)1.72109233
155Cerebral aneurysm (HP:0004944)1.70851924
156EMG: neuropathic changes (HP:0003445)1.70570287
157Degeneration of anterior horn cells (HP:0002398)1.70522032
158Abnormality of the anterior horn cell (HP:0006802)1.70522032
159Achilles tendon contracture (HP:0001771)1.70382727
160Methylmalonic acidemia (HP:0002912)1.69187611
161Hypoplastic left heart (HP:0004383)1.66369133
162Horseshoe kidney (HP:0000085)1.65973300
163Progressive external ophthalmoplegia (HP:0000590)1.65666885
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65373886
165Overriding aorta (HP:0002623)1.64390404
166Squamous cell carcinoma (HP:0002860)1.64251702
167Vertebral compression fractures (HP:0002953)1.62167816
168Partial duplication of thumb phalanx (HP:0009944)1.60971896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.85559894
2TRIB34.65885328
3VRK23.80836071
4SMG13.64947025
5PHKG23.49830582
6PHKG13.49830582
7PKN23.33706415
8BCKDK3.29768366
9OBSCN3.28837504
10MYLK2.54179324
11CDC72.24824848
12IRAK32.15433622
13NME22.13152808
14EPHB11.91838889
15LMTK21.87849561
16SIK11.86401692
17KDR1.86109896
18NEK11.79917563
19SRPK11.79732556
20LRRK21.79232466
21TTK1.78383145
22EPHA21.77864561
23DMPK1.73721320
24ILK1.71804542
25TESK21.66887159
26ARAF1.61604785
27STK161.52964366
28TESK11.52352627
29MAPKAPK31.46870970
30PAK31.42365760
31UHMK11.38949756
32BRSK11.35746481
33PDK21.34374763
34CDK71.32754910
35MAP3K101.32270295
36AURKA1.29924531
37PIK3CA1.27702251
38CHEK21.25978280
39TAOK21.24076808
40VRK11.22471240
41WEE11.21945721
42FLT31.21295242
43PRKD31.16728097
44PAK41.16288437
45MUSK1.13844762
46MAP2K21.13360501
47ICK1.13117213
48WNK41.12809906
49PAK21.12304409
50ZAK1.10362299
51TSSK61.08083211
52ROCK21.07191924
53PRKD11.06876630
54AURKB1.06824326
55PTK61.04740433
56CAMK2D1.04249121
57MET1.03059408
58MAP2K31.02847243
59TIE11.01954701
60PLK11.01953388
61BRAF1.01373981
62ATR1.00315080
63ERN10.99325826
64EEF2K0.97635645
65PIM20.97204871
66CCNB10.97143341
67STK390.96477163
68DAPK30.95581145
69TLK10.95106616
70STK40.91329363
71TAF10.90554173
72NME10.89292390
73LIMK10.88700502
74ABL20.88038225
75MAP3K110.87646306
76MST1R0.85546044
77MAP3K70.84388684
78RPS6KB20.83917526
79CDK80.83429688
80CHEK10.82853992
81ROCK10.82498147
82CDK40.81901318
83PRKG20.81429137
84PASK0.81007727
85NTRK10.78016031
86DAPK10.77517669
87DYRK30.76604511
88MAPK120.74380320
89PRPF4B0.72493904
90CAMK2G0.71767963
91MAPKAPK50.70592948
92TGFBR10.69026091
93NEK20.65398923
94PDGFRA0.65043080
95CSNK1A1L0.63568344
96PLK40.62187889
97MTOR0.60678711
98TRPM70.59805977
99HIPK20.58619985
100CDK120.58543068
101CDC42BPA0.58411349
102IRAK20.56605721
103MARK20.56564501
104BMX0.55298106
105CDK11A0.55218246
106PRKCI0.54973784
107CDK90.54858020
108CSNK2A20.52330156
109PLK30.51965504
110CSNK2A10.51541078
111CSNK1G10.51479834
112PIK3CG0.50515473
113STK100.47782254
114CDK20.47708382
115PRKD20.47266440
116EIF2AK10.46366476
117RPS6KA50.45123585
118AKT20.44961147
119DDR20.44872189
120CDK10.44847976
121CAMK2B0.44300045
122MAPK150.42977078
123CDK150.42832962
124PDK30.42673445
125PDK40.42673445
126MAP4K20.41742957
127RPS6KA40.41495753
128MAP2K10.41091827
129PAK10.40768671
130MAP3K80.39632601
131EPHB20.38493542
132MST40.36985267
133CDK180.36559487
134SCYL20.36371271
135BUB10.35648346
136CAMK1G0.34866705
137TGFBR20.34210533
138PRKACB0.33943478
139CAMK10.33806708
140PKN10.33428135
141ALK0.32832981
142MAP3K30.32774947
143STK240.29471621
144PRKACA0.29189633
145DYRK1B0.28258802
146CDK140.27463312
147CSNK1G30.26272236
148PBK0.25397725
149CAMK2A0.25267244
150MAPKAPK20.24609786
151PRKACG0.24348874
152RIPK10.24103181
153PTK20.23429768
154ADRBK10.21946486
155MAPK110.21733925
156CDK190.20919952

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.62386538
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.62822973
3Oxidative phosphorylation_Homo sapiens_hsa001903.34901752
4Cardiac muscle contraction_Homo sapiens_hsa042603.30502578
5Parkinsons disease_Homo sapiens_hsa050123.29737261
6Base excision repair_Homo sapiens_hsa034103.01076793
7Mismatch repair_Homo sapiens_hsa034302.61940579
8Propanoate metabolism_Homo sapiens_hsa006402.61572131
9Fatty acid degradation_Homo sapiens_hsa000712.57210174
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46758124
11Carbon metabolism_Homo sapiens_hsa012002.44116426
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.39383286
13Dilated cardiomyopathy_Homo sapiens_hsa054142.34324096
14Alzheimers disease_Homo sapiens_hsa050102.28663710
15Fatty acid elongation_Homo sapiens_hsa000622.15713124
16Fatty acid metabolism_Homo sapiens_hsa012122.12631552
17Ribosome_Homo sapiens_hsa030102.10950158
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10827761
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98379758
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96063927
21Homologous recombination_Homo sapiens_hsa034401.92266083
22Huntingtons disease_Homo sapiens_hsa050161.91510344
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90307056
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.88092175
25Sulfur relay system_Homo sapiens_hsa041221.87774363
26Pyruvate metabolism_Homo sapiens_hsa006201.83578169
27Nucleotide excision repair_Homo sapiens_hsa034201.82689027
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72463269
29Biosynthesis of amino acids_Homo sapiens_hsa012301.69791034
30Protein export_Homo sapiens_hsa030601.68662169
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59251200
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43221269
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41230378
34RNA transport_Homo sapiens_hsa030131.40793906
35Cell cycle_Homo sapiens_hsa041101.38316715
36Butanoate metabolism_Homo sapiens_hsa006501.32360421
37Vitamin B6 metabolism_Homo sapiens_hsa007501.29467804
38Arginine and proline metabolism_Homo sapiens_hsa003301.29021210
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28874895
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16157816
41Non-homologous end-joining_Homo sapiens_hsa034501.12067161
42Fanconi anemia pathway_Homo sapiens_hsa034601.11009737
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10789626
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09889626
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05093299
46Viral myocarditis_Homo sapiens_hsa054161.04122549
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99522577
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98907577
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96706424
50Folate biosynthesis_Homo sapiens_hsa007900.94434543
51Proteasome_Homo sapiens_hsa030500.93108103
52Tryptophan metabolism_Homo sapiens_hsa003800.91599227
53Pentose phosphate pathway_Homo sapiens_hsa000300.89210386
54ECM-receptor interaction_Homo sapiens_hsa045120.86266025
55Steroid biosynthesis_Homo sapiens_hsa001000.85977281
56Starch and sucrose metabolism_Homo sapiens_hsa005000.83591980
57Peroxisome_Homo sapiens_hsa041460.82157639
58Focal adhesion_Homo sapiens_hsa045100.80262451
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79670091
60Galactose metabolism_Homo sapiens_hsa000520.75952317
61N-Glycan biosynthesis_Homo sapiens_hsa005100.75429893
62Sulfur metabolism_Homo sapiens_hsa009200.74474566
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.72181816
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.71760066
65Lysine degradation_Homo sapiens_hsa003100.69468179
66PPAR signaling pathway_Homo sapiens_hsa033200.67777072
67DNA replication_Homo sapiens_hsa030300.66486364
68Selenocompound metabolism_Homo sapiens_hsa004500.66315273
69Insulin resistance_Homo sapiens_hsa049310.65372762
70Tight junction_Homo sapiens_hsa045300.64746681
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.64207831
72RNA polymerase_Homo sapiens_hsa030200.62958517
73Metabolic pathways_Homo sapiens_hsa011000.62557793
74Glutathione metabolism_Homo sapiens_hsa004800.62451589
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61262407
76Bladder cancer_Homo sapiens_hsa052190.58912741
77mRNA surveillance pathway_Homo sapiens_hsa030150.56918008
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.56672566
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56562165
80Notch signaling pathway_Homo sapiens_hsa043300.55607488
81RNA degradation_Homo sapiens_hsa030180.54517970
82Basal transcription factors_Homo sapiens_hsa030220.54334991
83Glucagon signaling pathway_Homo sapiens_hsa049220.53530700
84Nitrogen metabolism_Homo sapiens_hsa009100.51831062
85AMPK signaling pathway_Homo sapiens_hsa041520.51417352
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51255066
87Insulin signaling pathway_Homo sapiens_hsa049100.51239903
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.50382730
89Other glycan degradation_Homo sapiens_hsa005110.49727560
90Vitamin digestion and absorption_Homo sapiens_hsa049770.48111836
91Pyrimidine metabolism_Homo sapiens_hsa002400.47395326
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.46762204
93p53 signaling pathway_Homo sapiens_hsa041150.45304357
94Fructose and mannose metabolism_Homo sapiens_hsa000510.43722651
95Fatty acid biosynthesis_Homo sapiens_hsa000610.43466516
96Prion diseases_Homo sapiens_hsa050200.42901407
97Proteoglycans in cancer_Homo sapiens_hsa052050.42480219
98HIF-1 signaling pathway_Homo sapiens_hsa040660.41487525
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40809478
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39352726
101beta-Alanine metabolism_Homo sapiens_hsa004100.38844313
102Basal cell carcinoma_Homo sapiens_hsa052170.38825657
103Tyrosine metabolism_Homo sapiens_hsa003500.38409751
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37438511
105Systemic lupus erythematosus_Homo sapiens_hsa053220.37255820
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36666503
107Purine metabolism_Homo sapiens_hsa002300.33929076
108Epstein-Barr virus infection_Homo sapiens_hsa051690.33686659
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32973275
110Thyroid cancer_Homo sapiens_hsa052160.32747943
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32713699
112One carbon pool by folate_Homo sapiens_hsa006700.31661277
113Hedgehog signaling pathway_Homo sapiens_hsa043400.30570601
114Protein digestion and absorption_Homo sapiens_hsa049740.29642423
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.29152443
116Renal cell carcinoma_Homo sapiens_hsa052110.28640400
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27022764
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26891008
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26664037
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.25818548
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24990178
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24937572
123Spliceosome_Homo sapiens_hsa030400.24328799
124Viral carcinogenesis_Homo sapiens_hsa052030.24075458
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22675519
126Fat digestion and absorption_Homo sapiens_hsa049750.21244896
127Small cell lung cancer_Homo sapiens_hsa052220.20860014
128Arginine biosynthesis_Homo sapiens_hsa002200.17387054
129HTLV-I infection_Homo sapiens_hsa051660.16977574
130Phenylalanine metabolism_Homo sapiens_hsa003600.16037441
131Vibrio cholerae infection_Homo sapiens_hsa051100.15562567
132Oocyte meiosis_Homo sapiens_hsa041140.15308743
133Amoebiasis_Homo sapiens_hsa051460.15106052
134Alcoholism_Homo sapiens_hsa050340.15086135
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.14012531

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