TMEM161B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein prenylation (GO:0018342)6.51923133
2prenylation (GO:0097354)6.51923133
3presynaptic membrane assembly (GO:0097105)5.39624540
4presynaptic membrane organization (GO:0097090)5.22245701
5positive regulation of mitotic sister chromatid separation (GO:1901970)4.39622296
6positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.39622296
7positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.39622296
8nuclear pore organization (GO:0006999)3.92113384
9positive regulation of mitochondrial fission (GO:0090141)3.90880304
10nuclear pore complex assembly (GO:0051292)3.87930062
11L-fucose metabolic process (GO:0042354)3.86496828
12L-fucose catabolic process (GO:0042355)3.86496828
13fucose catabolic process (GO:0019317)3.86496828
14neuron cell-cell adhesion (GO:0007158)3.74019803
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.68596592
16regulation of translation, ncRNA-mediated (GO:0045974)3.68596592
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.68596592
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.68542498
19gamma-aminobutyric acid signaling pathway (GO:0007214)3.68439777
20glutamate receptor signaling pathway (GO:0007215)3.68269118
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68181705
22synaptic transmission, glutamatergic (GO:0035249)3.66321291
23neural tube formation (GO:0001841)3.60285886
24DNA replication checkpoint (GO:0000076)3.58398638
25regulation of DNA endoreduplication (GO:0032875)3.58003824
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.57337358
27microglial cell activation (GO:0001774)3.55954248
28monoubiquitinated protein deubiquitination (GO:0035520)3.55024934
29replication fork processing (GO:0031297)3.54669694
30double-strand break repair via homologous recombination (GO:0000724)3.51907085
31G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.50237798
32organ growth (GO:0035265)3.48460112
33recombinational repair (GO:0000725)3.48276358
34kidney morphogenesis (GO:0060993)3.44976082
35L-amino acid import (GO:0043092)3.43519051
36neurotransmitter-gated ion channel clustering (GO:0072578)3.42292184
37regulation of sister chromatid cohesion (GO:0007063)3.39710428
38neuron-neuron synaptic transmission (GO:0007270)3.37860479
39synapsis (GO:0007129)3.32066357
40resolution of meiotic recombination intermediates (GO:0000712)3.30431812
41centriole replication (GO:0007099)3.29185948
42positive regulation of neurotransmitter secretion (GO:0001956)3.28962991
43regulation of centriole replication (GO:0046599)3.28396231
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26686266
45mitochondrial RNA metabolic process (GO:0000959)3.26614730
46serotonin receptor signaling pathway (GO:0007210)3.26512458
47histone-serine phosphorylation (GO:0035404)3.26278743
48negative regulation of neurotransmitter transport (GO:0051589)3.22434194
49chromatin remodeling at centromere (GO:0031055)3.21599122
50regulation of centrosome cycle (GO:0046605)3.21515377
51meiotic chromosome segregation (GO:0045132)3.21391572
52DNA double-strand break processing (GO:0000729)3.20547815
53CENP-A containing nucleosome assembly (GO:0034080)3.18711296
54regulation of centrosome duplication (GO:0010824)3.12965469
55postsynaptic membrane organization (GO:0001941)3.12224024
56microtubule anchoring (GO:0034453)3.10365110
57histone H3-K4 trimethylation (GO:0080182)3.09263795
58long-term synaptic potentiation (GO:0060291)3.08258553
59amino acid import (GO:0043090)3.04955614
60positive regulation of protein homodimerization activity (GO:0090073)3.01726459
61response to histamine (GO:0034776)3.01705484
62dentate gyrus development (GO:0021542)3.00277943
63regulation of mitotic spindle checkpoint (GO:1903504)2.99917181
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99917181
65double-strand break repair via nonhomologous end joining (GO:0006303)2.98875023
66non-recombinational repair (GO:0000726)2.98875023
67atrial cardiac muscle cell action potential (GO:0086014)2.97963440
68positive regulation of monocyte chemotaxis (GO:0090026)2.97555195
69positive regulation of chromosome segregation (GO:0051984)2.96448580
70somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93125850
71somatic hypermutation of immunoglobulin genes (GO:0016446)2.93125850
72cerebral cortex radially oriented cell migration (GO:0021799)2.92813725
73histone exchange (GO:0043486)2.92708502
74positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.91561635
75mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.91561635
76transmission of nerve impulse (GO:0019226)2.90898506
77C4-dicarboxylate transport (GO:0015740)2.90509898
78startle response (GO:0001964)2.88050970
79sister chromatid segregation (GO:0000819)2.87861914
80telomere maintenance via recombination (GO:0000722)2.87476934
81mitotic recombination (GO:0006312)2.84158296
82regulation of pigment cell differentiation (GO:0050932)2.83838288
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80313921
84maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80245568
85microtubule depolymerization (GO:0007019)2.80124704
86histone mRNA metabolic process (GO:0008334)2.79628471
87methionine biosynthetic process (GO:0009086)2.79279265
88kinetochore organization (GO:0051383)2.79173087
89natural killer cell activation involved in immune response (GO:0002323)2.78427907
90sphingomyelin metabolic process (GO:0006684)2.78158284
91pore complex assembly (GO:0046931)2.77782346
92mitotic sister chromatid segregation (GO:0000070)2.76988358
93regulation of mitochondrial fission (GO:0090140)2.75686911
94signal peptide processing (GO:0006465)2.75137461
95protein K11-linked deubiquitination (GO:0035871)2.74221737
96detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.73849022
97eosinophil chemotaxis (GO:0048245)2.73598127
98regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72888072
99rRNA catabolic process (GO:0016075)2.72721795
100gamma-aminobutyric acid transport (GO:0015812)2.72611963
101intra-S DNA damage checkpoint (GO:0031573)2.71815168
102organelle disassembly (GO:1903008)2.71416779
103developmental pigmentation (GO:0048066)2.70940161
104sleep (GO:0030431)2.69756534
105regulation of amino acid transport (GO:0051955)2.69373855
106positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.67931108
107regulation of nuclear cell cycle DNA replication (GO:0033262)2.66488776
108long-chain fatty acid biosynthetic process (GO:0042759)2.66475197
109nucleobase biosynthetic process (GO:0046112)2.66022099
110reciprocal meiotic recombination (GO:0007131)2.65507399
111reciprocal DNA recombination (GO:0035825)2.65507399
112mechanosensory behavior (GO:0007638)2.65381329
113negative regulation of neurotransmitter secretion (GO:0046929)2.65213264
114purine nucleobase biosynthetic process (GO:0009113)2.64708064
115positive regulation of histone H3-K4 methylation (GO:0051571)2.62028891
116positive regulation of cellular amide metabolic process (GO:0034250)2.61757711
117regulation of glutamate secretion (GO:0014048)2.61744326
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60549777
119negative regulation of dendrite morphogenesis (GO:0050774)2.59358945
120histone H3-K9 methylation (GO:0051567)2.59096349
121attachment of spindle microtubules to kinetochore (GO:0008608)2.58431910
122neurotransmitter uptake (GO:0001504)2.57478910
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.57136700
124protein localization to kinetochore (GO:0034501)2.57013830
125mitochondrial respiratory chain complex I assembly (GO:0032981)2.56306339
126NADH dehydrogenase complex assembly (GO:0010257)2.56306339
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56306339
128regulation of sister chromatid segregation (GO:0033045)2.55676100
129regulation of mitotic sister chromatid separation (GO:0010965)2.55676100
130regulation of mitotic sister chromatid segregation (GO:0033047)2.55676100
131regulation of mitotic metaphase/anaphase transition (GO:0030071)2.54482964
132regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54482964
133protein localization to synapse (GO:0035418)2.53491243
134mitotic G2/M transition checkpoint (GO:0044818)2.52239306
135DNA replication-dependent nucleosome assembly (GO:0006335)2.52228684
136DNA replication-dependent nucleosome organization (GO:0034723)2.52228684
137ribosomal small subunit assembly (GO:0000028)2.51890759
138mitotic sister chromatid cohesion (GO:0007064)2.51867624
139transcription from mitochondrial promoter (GO:0006390)2.51693524
140ribonucleoprotein complex disassembly (GO:0032988)2.51517932
141otic vesicle formation (GO:0030916)2.51278405
142protein complex biogenesis (GO:0070271)2.51184050
143positive regulation of lymphocyte migration (GO:2000403)2.50880855
144regulation of synaptic transmission, glutamatergic (GO:0051966)2.50648214
145respiratory chain complex IV assembly (GO:0008535)2.49828228
146regulation of glutamate receptor signaling pathway (GO:1900449)2.49680577
147regulation of inositol phosphate biosynthetic process (GO:0010919)2.49295299
148positive regulation by symbiont of host defense response (GO:0052509)2.48033728
149modulation by symbiont of host defense response (GO:0052031)2.48033728
150modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48033728
151modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.48033728
152positive regulation by organism of defense response of other organism involved in symbiotic interact2.48033728
153modulation by symbiont of host immune response (GO:0052553)2.48033728
154vocalization behavior (GO:0071625)2.47606751
155regulation of heat generation (GO:0031650)2.47555956
156chaperone-mediated protein transport (GO:0072321)2.47454354
157dopamine transport (GO:0015872)2.47356920
158aggressive behavior (GO:0002118)2.46865950
159peptidyl-histidine modification (GO:0018202)2.46859500
160regulation of hexokinase activity (GO:1903299)2.46470614
161regulation of glucokinase activity (GO:0033131)2.46470614
162positive regulation of membrane potential (GO:0045838)2.45880365
163DNA replication-independent nucleosome organization (GO:0034724)2.45425258
164DNA replication-independent nucleosome assembly (GO:0006336)2.45425258
165centrosome organization (GO:0051297)2.45305651
166positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.44822496
167regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.44822496
168telomere maintenance (GO:0000723)2.44724889
169positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.44348278
170negative regulation of astrocyte differentiation (GO:0048712)2.43766014
171negative regulation of homotypic cell-cell adhesion (GO:0034111)2.43618079
172regulation of histone H3-K4 methylation (GO:0051569)2.43421376
173regulation of timing of cell differentiation (GO:0048505)2.43052452
174peptidyl-lysine trimethylation (GO:0018023)2.42945812
175double-strand break repair (GO:0006302)2.42525791
1767-methylguanosine RNA capping (GO:0009452)2.41885748
177RNA capping (GO:0036260)2.41885748
178regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41846814
179terpenoid biosynthetic process (GO:0016114)2.41616335
180negative regulation of DNA recombination (GO:0045910)2.40999712
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40669791
182synaptic vesicle endocytosis (GO:0048488)2.40659143
183folic acid-containing compound biosynthetic process (GO:0009396)2.40619780
184microtubule organizing center organization (GO:0031023)2.40615711
185central nervous system myelination (GO:0022010)2.40118024
186axon ensheathment in central nervous system (GO:0032291)2.40118024
187telomere organization (GO:0032200)2.39996066
188postreplication repair (GO:0006301)2.39938204
189regulation of neuron projection regeneration (GO:0070570)2.39346541
190regulation of axon regeneration (GO:0048679)2.39346541
191limb bud formation (GO:0060174)2.39174985
192eosinophil migration (GO:0072677)2.37576755
1937-methylguanosine mRNA capping (GO:0006370)2.36403566
194transferrin transport (GO:0033572)2.36018677
195regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.34875730
196negative regulation of dendrite development (GO:2000171)2.34875057
197cellular response to exogenous dsRNA (GO:0071360)2.34228129
198keratinocyte development (GO:0003334)2.34061976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.27507596
2E2F7_22180533_ChIP-Seq_HELA_Human4.15724563
3TAF15_26573619_Chip-Seq_HEK293_Human3.47766397
4EZH2_22144423_ChIP-Seq_EOC_Human3.36934422
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16926291
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.02265111
7* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86357152
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75731440
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.71435735
10GATA1_22025678_ChIP-Seq_K562_Human2.70139636
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62568454
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.60879168
13* FUS_26573619_Chip-Seq_HEK293_Human2.59241564
14ELK1_19687146_ChIP-ChIP_HELA_Human2.55653496
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46522678
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.43877273
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.37020020
18* P300_19829295_ChIP-Seq_ESCs_Human2.29421926
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.24765544
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20467771
21* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18520089
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15309766
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12348602
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.05074808
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03627230
26VDR_22108803_ChIP-Seq_LS180_Human2.01716563
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98685049
28EWS_26573619_Chip-Seq_HEK293_Human1.98670625
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.94491616
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89125239
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88306290
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84847096
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.83738304
34VDR_23849224_ChIP-Seq_CD4+_Human1.81744657
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77182893
36E2F1_18555785_Chip-Seq_ESCs_Mouse1.74394045
37AR_21572438_ChIP-Seq_LNCaP_Human1.73577222
38SMAD4_21799915_ChIP-Seq_A2780_Human1.73026285
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.69121289
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67747805
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67255213
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66468017
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66322953
44P53_22387025_ChIP-Seq_ESCs_Mouse1.64635955
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64157036
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.63302324
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62475330
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61223480
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.60809433
50ER_23166858_ChIP-Seq_MCF-7_Human1.60345847
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60264451
52STAT3_18555785_Chip-Seq_ESCs_Mouse1.59947279
53* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58053923
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56590706
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55814012
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.55728288
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.53409283
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50431203
59* AR_25329375_ChIP-Seq_VCAP_Human1.50146268
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49453491
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.48841890
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.48792163
63IGF1R_20145208_ChIP-Seq_DFB_Human1.48371226
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48244626
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48058934
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.46497447
67* MYC_18940864_ChIP-ChIP_HL60_Human1.46482415
68P300_18555785_Chip-Seq_ESCs_Mouse1.44422029
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43782319
70STAT3_23295773_ChIP-Seq_U87_Human1.41957937
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41344513
72* ETS1_20019798_ChIP-Seq_JURKAT_Human1.40158580
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.38338410
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38081210
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37947470
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.37744381
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37148561
78RNF2_27304074_Chip-Seq_NSC_Mouse1.36466562
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.36133597
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.36028688
81FOXP3_21729870_ChIP-Seq_TREG_Human1.35683274
82TP53_18474530_ChIP-ChIP_U2OS_Human1.35469318
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35283356
84JUN_21703547_ChIP-Seq_K562_Human1.35038002
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.33512213
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33409758
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33146336
88CBP_20019798_ChIP-Seq_JUKART_Human1.31778148
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31778148
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30411315
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29396748
92IRF1_19129219_ChIP-ChIP_H3396_Human1.29229717
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.28523717
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28190052
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27751650
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27716223
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.27457286
98* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26541029
99TCF4_23295773_ChIP-Seq_U87_Human1.25752864
100EED_16625203_ChIP-ChIP_MESCs_Mouse1.24657496
101CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24597289
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23594139
103REST_21632747_ChIP-Seq_MESCs_Mouse1.23126907
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21033483
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20958581
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19593591
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19441128
108* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18645612
109* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18645612
110PU1_27457419_Chip-Seq_LIVER_Mouse1.18551443
111KLF4_18555785_Chip-Seq_ESCs_Mouse1.15763076
112ZNF274_21170338_ChIP-Seq_K562_Hela1.15188867
113ZFX_18555785_Chip-Seq_ESCs_Mouse1.14020406
114* SOX9_26525672_Chip-Seq_HEART_Mouse1.13633004
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13628192
116ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12555273
117SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12464229
118CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12236287
119TP53_16413492_ChIP-PET_HCT116_Human1.11591857
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11232634
121CTCF_18555785_Chip-Seq_ESCs_Mouse1.10778525
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09132439
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09113618
124KDM2B_26808549_Chip-Seq_REH_Human1.09021512
125RUNX2_22187159_ChIP-Seq_PCA_Human1.08705372
126IRF8_21731497_ChIP-ChIP_J774_Mouse1.08314839
127* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07422251
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06220965
129BCAT_22108803_ChIP-Seq_LS180_Human1.06031812
130SRF_21415370_ChIP-Seq_HL-1_Mouse1.04939551
131EZH2_27304074_Chip-Seq_ESCs_Mouse1.03970390
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02750280
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02628569
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01403858
135FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00941463
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00923913
137TCF4_22108803_ChIP-Seq_LS180_Human1.00273437
138HTT_18923047_ChIP-ChIP_STHdh_Human0.99403719
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.98396947
140MYC_18555785_ChIP-Seq_MESCs_Mouse0.98272238
141* NANOG_19829295_ChIP-Seq_ESCs_Human0.97236104
142* SOX2_19829295_ChIP-Seq_ESCs_Human0.97236104
143PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97233546
144PHF8_20622853_ChIP-Seq_HELA_Human0.96673118
145TP53_22573176_ChIP-Seq_HFKS_Human0.96471114
146NFYB_21822215_ChIP-Seq_K562_Human0.96209669
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95827962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.11814320
2MP0000569_abnormal_digit_pigmentation3.22084865
3MP0001188_hyperpigmentation3.05364186
4MP0010094_abnormal_chromosome_stability2.90133167
5MP0009745_abnormal_behavioral_response2.81749453
6MP0002876_abnormal_thyroid_physiology2.81540238
7MP0006292_abnormal_olfactory_placode2.70583869
8MP0005171_absent_coat_pigmentation2.66184712
9MP0004859_abnormal_synaptic_plasticity2.60272106
10MP0005646_abnormal_pituitary_gland2.44682436
11MP0002572_abnormal_emotion/affect_behav2.39599348
12MP0003787_abnormal_imprinting2.37636190
13MP0003635_abnormal_synaptic_transmissio2.37241152
14MP0008007_abnormal_cellular_replicative2.33481958
15MP0009046_muscle_twitch2.32504770
16MP0001905_abnormal_dopamine_level2.27772183
17MP0004885_abnormal_endolymph2.23845453
18MP0003890_abnormal_embryonic-extraembry2.22885201
19MP0002064_seizures2.22253428
20MP0001529_abnormal_vocalization2.21166438
21MP0003878_abnormal_ear_physiology2.19950940
22MP0005377_hearing/vestibular/ear_phenot2.19950940
23MP0001501_abnormal_sleep_pattern2.19254583
24MP0002736_abnormal_nociception_after2.18899604
25MP0003136_yellow_coat_color2.17608223
26MP0002063_abnormal_learning/memory/cond2.13971191
27MP0003950_abnormal_plasma_membrane2.12319451
28MP0002009_preneoplasia2.12124137
29MP0001485_abnormal_pinna_reflex2.10780834
30MP0001968_abnormal_touch/_nociception2.08660967
31MP0004957_abnormal_blastocyst_morpholog2.02591209
32MP0003693_abnormal_embryo_hatching2.00906818
33MP0006072_abnormal_retinal_apoptosis1.96453369
34MP0008260_abnormal_autophagy1.95425426
35MP0002272_abnormal_nervous_system1.95374876
36MP0001486_abnormal_startle_reflex1.92262809
37MP0003937_abnormal_limbs/digits/tail_de1.89997429
38MP0003111_abnormal_nucleus_morphology1.89944768
39MP0001440_abnormal_grooming_behavior1.87886968
40MP0002067_abnormal_sensory_capabilities1.86466632
41MP0005253_abnormal_eye_physiology1.86250732
42MP0000383_abnormal_hair_follicle1.85874517
43MP0003195_calcinosis1.85258836
44MP0002938_white_spotting1.71732301
45MP0004270_analgesia1.68469727
46MP0002282_abnormal_trachea_morphology1.66342811
47MP0003077_abnormal_cell_cycle1.65596185
48MP0001661_extended_life_span1.57759679
49MP0000647_abnormal_sebaceous_gland1.53013298
50MP0000427_abnormal_hair_cycle1.51819030
51MP0000372_irregular_coat_pigmentation1.49953755
52MP0004043_abnormal_pH_regulation1.49477580
53MP0005645_abnormal_hypothalamus_physiol1.49258762
54MP0003646_muscle_fatigue1.46574239
55MP0005174_abnormal_tail_pigmentation1.44372549
56MP0002735_abnormal_chemical_nociception1.43898152
57MP0001919_abnormal_reproductive_system1.43826467
58MP0000778_abnormal_nervous_system1.43334087
59MP0009697_abnormal_copulation1.43109031
60MP0010678_abnormal_skin_adnexa1.42741423
61MP0005386_behavior/neurological_phenoty1.39874429
62MP0004924_abnormal_behavior1.39874429
63MP0001293_anophthalmia1.38536063
64MP0005409_darkened_coat_color1.37394057
65MP0000566_synostosis1.37071299
66MP0002734_abnormal_mechanical_nocicepti1.36773846
67MP0002557_abnormal_social/conspecific_i1.34171626
68MP0001502_abnormal_circadian_rhythm1.33022249
69MP0005187_abnormal_penis_morphology1.32615447
70MP0002102_abnormal_ear_morphology1.32317080
71MP0004142_abnormal_muscle_tone1.25743262
72MP0005410_abnormal_fertilization1.24183502
73MP0002396_abnormal_hematopoietic_system1.24102862
74MP0002095_abnormal_skin_pigmentation1.22770599
75MP0009379_abnormal_foot_pigmentation1.22278216
76MP0001963_abnormal_hearing_physiology1.21350421
77MP0008877_abnormal_DNA_methylation1.20500243
78MP0004145_abnormal_muscle_electrophysio1.17653473
79MP0003718_maternal_effect1.15528008
80MP0008932_abnormal_embryonic_tissue1.14415391
81MP0000026_abnormal_inner_ear1.13825501
82MP0005551_abnormal_eye_electrophysiolog1.12937347
83MP0008058_abnormal_DNA_repair1.12891813
84MP0000015_abnormal_ear_pigmentation1.12343338
85MP0002751_abnormal_autonomic_nervous1.12225908
86MP0001986_abnormal_taste_sensitivity1.11796516
87MP0001286_abnormal_eye_development1.10862909
88MP0003252_abnormal_bile_duct1.09325253
89MP0001984_abnormal_olfaction1.02815794
90MP0003786_premature_aging1.01272842
91MP0008569_lethality_at_weaning1.00840239
92MP0003690_abnormal_glial_cell1.00704721
93MP0003631_nervous_system_phenotype1.00585893
94MP0005391_vision/eye_phenotype1.00554743
95MP0000653_abnormal_sex_gland0.99701202
96MP0001177_atelectasis0.99481290
97MP0002148_abnormal_hypersensitivity_rea0.97188082
98MP0004147_increased_porphyrin_level0.96513820
99MP0001145_abnormal_male_reproductive0.96369623
100MP0004742_abnormal_vestibular_system0.93335152
101MP0002160_abnormal_reproductive_system0.93253723
102MP0000579_abnormal_nail_morphology0.93149150
103MP0002277_abnormal_respiratory_mucosa0.92833582
104MP0002254_reproductive_system_inflammat0.92114924
105MP0004381_abnormal_hair_follicle0.91979915
106MP0005408_hypopigmentation0.91937852
107MP0002066_abnormal_motor_capabilities/c0.90452098
108MP0003633_abnormal_nervous_system0.88692327
109MP0003632_abnormal_nervous_system0.88003048
110MP0002928_abnormal_bile_duct0.86094766
111MP0002132_abnormal_respiratory_system0.84585311
112MP0002184_abnormal_innervation0.83951522
113MP0003698_abnormal_male_reproductive0.82358148
114MP0002882_abnormal_neuron_morphology0.81462543
115MP0001697_abnormal_embryo_size0.80623005
116MP0002088_abnormal_embryonic_growth/wei0.80609732
117MP0005671_abnormal_response_to0.80452747
118MP0002733_abnormal_thermal_nociception0.80438630
119MP0002229_neurodegeneration0.80035905
120MP0005451_abnormal_body_composition0.79949827
121MP0003984_embryonic_growth_retardation0.79219324
122MP0004134_abnormal_chest_morphology0.78583445
123MP0005389_reproductive_system_phenotype0.78449582
124MP0000631_abnormal_neuroendocrine_gland0.78377222
125MP0005075_abnormal_melanosome_morpholog0.78372458
126MP0004215_abnormal_myocardial_fiber0.78085992
127MP0005380_embryogenesis_phenotype0.77665634
128MP0001672_abnormal_embryogenesis/_devel0.77665634
129MP0001853_heart_inflammation0.77505563
130MP0001764_abnormal_homeostasis0.77296501
131MP0002234_abnormal_pharynx_morphology0.76580487
132MP0000350_abnormal_cell_proliferation0.76066478
133MP0006276_abnormal_autonomic_nervous0.75993518
134MP0008961_abnormal_basal_metabolism0.75303036
135MP0001970_abnormal_pain_threshold0.75218937
136MP0002163_abnormal_gland_morphology0.74280187
137MP0000920_abnormal_myelination0.73976044
138MP0010307_abnormal_tumor_latency0.73644173
139MP0008995_early_reproductive_senescence0.72736065
140MP0000428_abnormal_craniofacial_morphol0.72647551
141MP0001119_abnormal_female_reproductive0.72446343
142MP0002638_abnormal_pupillary_reflex0.72423756
143MP0000371_diluted_coat_color0.72175719
144MP0000681_abnormal_thyroid_gland0.71592358
145MP0003656_abnormal_erythrocyte_physiolo0.70736075
146MP0005085_abnormal_gallbladder_physiolo0.69935142
147MP0005379_endocrine/exocrine_gland_phen0.69927293
148MP0005266_abnormal_metabolism0.69465220
149MP0001664_abnormal_digestion0.69351589
150MP0005423_abnormal_somatic_nervous0.69339979
151MP0008872_abnormal_physiological_respon0.68792693
152MP0002084_abnormal_developmental_patter0.68777074
153MP0003879_abnormal_hair_cell0.68464635
154MP0002152_abnormal_brain_morphology0.67740224
155MP0001929_abnormal_gametogenesis0.67659223
156MP0002109_abnormal_limb_morphology0.66367420
157MP0002332_abnormal_exercise_endurance0.66283238
158MP0008057_abnormal_DNA_replication0.66201637
159MP0002822_catalepsy0.65832146
160MP0006035_abnormal_mitochondrial_morpho0.65498596
161MP0002210_abnormal_sex_determination0.65434436

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.09569501
2Abnormal hair whorl (HP:0010721)4.80232261
3Epileptic encephalopathy (HP:0200134)4.32037917
4Abnormality of secondary sexual hair (HP:0009888)4.16292372
5Abnormality of the axillary hair (HP:0100134)4.16292372
6Atonic seizures (HP:0010819)3.56812162
7Febrile seizures (HP:0002373)3.53956492
8Pancreatic fibrosis (HP:0100732)3.50594926
9Hyperventilation (HP:0002883)3.43099276
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.31609813
11Abnormality of alanine metabolism (HP:0010916)3.31609813
12Hyperalaninemia (HP:0003348)3.31609813
13Abnormality of chromosome stability (HP:0003220)3.26682013
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.06104027
15Onycholysis (HP:0001806)2.91031326
16True hermaphroditism (HP:0010459)2.85516806
17Increased serum pyruvate (HP:0003542)2.82689399
18Abnormality of glycolysis (HP:0004366)2.82689399
19Birth length less than 3rd percentile (HP:0003561)2.74094786
20Medial flaring of the eyebrow (HP:0010747)2.73741490
21Acute necrotizing encephalopathy (HP:0006965)2.73712044
22Aplasia cutis congenita (HP:0001057)2.63569237
23Congenital, generalized hypertrichosis (HP:0004540)2.60967082
24Dialeptic seizures (HP:0011146)2.59331810
25Progressive macrocephaly (HP:0004481)2.58901233
26Absent/shortened dynein arms (HP:0200106)2.57033753
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.57033753
28Abnormality of the pons (HP:0007361)2.56470928
29Meckel diverticulum (HP:0002245)2.52898945
30Increased hepatocellular lipid droplets (HP:0006565)2.48433044
31Chronic hepatic failure (HP:0100626)2.48242083
32Hypoplasia of the pons (HP:0012110)2.45671140
33Autoamputation (HP:0001218)2.44644739
34Nephrogenic diabetes insipidus (HP:0009806)2.44375258
35Focal seizures (HP:0007359)2.43175010
36Abnormality of the ileum (HP:0001549)2.41116520
37Hypoplastic left heart (HP:0004383)2.36176803
38Renal cortical cysts (HP:0000803)2.35361429
39Abnormality of the preputium (HP:0100587)2.34865021
40Abnormality of incisor morphology (HP:0011063)2.32703289
41Slow-growing hair (HP:0002217)2.30624411
42Abnormality of hair growth rate (HP:0011363)2.30624411
43Gait imbalance (HP:0002141)2.30380805
44Absence seizures (HP:0002121)2.29692752
45Abnormal mitochondria in muscle tissue (HP:0008316)2.29431421
46Congenital primary aphakia (HP:0007707)2.28879482
47Duodenal stenosis (HP:0100867)2.28846880
48Small intestinal stenosis (HP:0012848)2.28846880
49Type II lissencephaly (HP:0007260)2.26701512
50Pancreatic cysts (HP:0001737)2.26302084
51Lipid accumulation in hepatocytes (HP:0006561)2.26139156
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25294351
53Progressive cerebellar ataxia (HP:0002073)2.23313432
54Clubbing of toes (HP:0100760)2.21441348
55Protruding tongue (HP:0010808)2.19589370
56Duplicated collecting system (HP:0000081)2.19480101
57Absent septum pellucidum (HP:0001331)2.19426715
58Poor coordination (HP:0002370)2.18724774
59Sloping forehead (HP:0000340)2.18423565
60Molar tooth sign on MRI (HP:0002419)2.17667841
61Abnormality of midbrain morphology (HP:0002418)2.17667841
62Fair hair (HP:0002286)2.17551904
63Abnormality of binocular vision (HP:0011514)2.16212361
64Diplopia (HP:0000651)2.16212361
65Volvulus (HP:0002580)2.15744666
66Abnormality of the renal collecting system (HP:0004742)2.15572323
67Abnormality of the labia minora (HP:0012880)2.15221828
68Broad-based gait (HP:0002136)2.12332782
69Abnormality of the duodenum (HP:0002246)2.11085499
70Abnormality of the septum pellucidum (HP:0007375)2.09030087
713-Methylglutaconic aciduria (HP:0003535)2.06544768
72Preaxial hand polydactyly (HP:0001177)2.06280858
73Cerebellar dysplasia (HP:0007033)2.03895652
74Median cleft lip (HP:0000161)2.00833513
75Intestinal atresia (HP:0011100)2.00089993
76Acute encephalopathy (HP:0006846)1.99624243
77Congenital stationary night blindness (HP:0007642)1.98788894
78Abnormality of methionine metabolism (HP:0010901)1.98604489
79Absent hair (HP:0002298)1.98430068
80Microvesicular hepatic steatosis (HP:0001414)1.98416864
81Acute lymphatic leukemia (HP:0006721)1.97944589
82Abnormality of DNA repair (HP:0003254)1.97745139
83Hypoplastic labia majora (HP:0000059)1.97165444
84White forelock (HP:0002211)1.96913866
85Agnosia (HP:0010524)1.96892028
86Aplasia/Hypoplasia of the tibia (HP:0005772)1.96472552
87Hypoplastic heart (HP:0001961)1.94240196
88Patchy hypopigmentation of hair (HP:0011365)1.93651382
89Large for gestational age (HP:0001520)1.90027991
90Medulloblastoma (HP:0002885)1.89972725
91Sclerocornea (HP:0000647)1.89904357
92Abnormal lung lobation (HP:0002101)1.89789882
93Dry hair (HP:0011359)1.89605445
94Abnormality of the renal medulla (HP:0100957)1.89446077
95Acute myeloid leukemia (HP:0004808)1.89000919
96Hypoplastic iliac wings (HP:0002866)1.88511070
97Nephronophthisis (HP:0000090)1.87565866
98Optic neuritis (HP:0100653)1.87548358
99Retrobulbar optic neuritis (HP:0100654)1.87548358
100Cystic liver disease (HP:0006706)1.85858048
101Gaze-evoked nystagmus (HP:0000640)1.85598130
102Colon cancer (HP:0003003)1.84550951
103Mitochondrial inheritance (HP:0001427)1.84376437
104Chromsome breakage (HP:0040012)1.83872643
105Methylmalonic acidemia (HP:0002912)1.83837011
106Homocystinuria (HP:0002156)1.82961766
107Abnormality of homocysteine metabolism (HP:0010919)1.82961766
108Abnormality of nail color (HP:0100643)1.81954078
109Triphalangeal thumb (HP:0001199)1.81764985
110Myelodysplasia (HP:0002863)1.80209340
111Absent radius (HP:0003974)1.79745612
112Attenuation of retinal blood vessels (HP:0007843)1.79370778
113Stomach cancer (HP:0012126)1.79065250
114Abnormality of the labia majora (HP:0012881)1.78283596
115Oligodactyly (hands) (HP:0001180)1.77868985
116Furrowed tongue (HP:0000221)1.76860818
117Cupped ear (HP:0000378)1.76322150
118Midline defect of the nose (HP:0004122)1.75659587
119Gastrointestinal atresia (HP:0002589)1.75219976
120Generalized hypopigmentation of hair (HP:0011358)1.74101138
121Aplasia involving bones of the extremities (HP:0009825)1.73769484
122Aplasia involving bones of the upper limbs (HP:0009823)1.73769484
123Aplasia of the phalanges of the hand (HP:0009802)1.73769484
124Neoplasm of the oral cavity (HP:0100649)1.73686120
125Abnormal biliary tract morphology (HP:0012440)1.72983886
126Tubular atrophy (HP:0000092)1.72201728
127Aplasia involving forearm bones (HP:0009822)1.71946171
128Absent forearm bone (HP:0003953)1.71946171
129Depressed nasal tip (HP:0000437)1.71102093
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.70897064
131Aganglionic megacolon (HP:0002251)1.70339723
132Decreased lacrimation (HP:0000633)1.67622261
133Generalized tonic-clonic seizures (HP:0002069)1.67602303
134Absent speech (HP:0001344)1.66378974
135Abnormality of the renal cortex (HP:0011035)1.65783650
136Pheochromocytoma (HP:0002666)1.65497022
137Genital tract atresia (HP:0001827)1.65469486
138Increased CSF lactate (HP:0002490)1.64439201
139Tubulointerstitial nephritis (HP:0001970)1.64276157
140Optic disc pallor (HP:0000543)1.64066905
141Abnormal biliary tract physiology (HP:0012439)1.63835682
142Bile duct proliferation (HP:0001408)1.63835682
143Abnormal respiratory epithelium morphology (HP:0012253)1.63726662
144Abnormal respiratory motile cilium morphology (HP:0005938)1.63726662
145Hypothermia (HP:0002045)1.63368231
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63172476
147Abnormality of sulfur amino acid metabolism (HP:0004339)1.62829969
148Abnormality of vitamin B metabolism (HP:0004340)1.61356792
149Abnormality of the vitamin B12 metabolism (HP:0004341)1.61337975
150Vaginal atresia (HP:0000148)1.61246787
151Male pseudohermaphroditism (HP:0000037)1.61210097
152Increased number of teeth (HP:0011069)1.60831736
153Abnormality of the carotid arteries (HP:0005344)1.60701633
154Nephroblastoma (Wilms tumor) (HP:0002667)1.60644384
155Calf muscle hypertrophy (HP:0008981)1.60352252
156Occipital encephalocele (HP:0002085)1.60162912
157Abnormality of the columella (HP:0009929)1.59632402
158Esophageal atresia (HP:0002032)1.59049230
159Congenital hepatic fibrosis (HP:0002612)1.58742971
160Inability to walk (HP:0002540)1.58654711
161Prostate neoplasm (HP:0100787)1.58488614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK5.00207779
2CASK3.72489127
3EPHA42.91458199
4MAP2K72.87733766
5BRSK22.67394389
6PRPF4B2.36530518
7AKT32.32017025
8PLK22.23637650
9TNIK2.21924882
10BMPR1B2.11316415
11CDC72.07147472
12NTRK32.04459404
13SIK31.89888786
14ACVR1B1.89505217
15MKNK11.75132122
16TRIM281.74323563
17IRAK31.72156387
18BMPR21.67239254
19MKNK21.65094374
20MST41.63168445
21WNK31.62929127
22ARAF1.61485587
23ZAK1.59610934
24BUB11.49586573
25MAP3K141.47910994
26NUAK11.47725777
27FRK1.47275522
28MAP3K121.46823399
29BRAF1.45979923
30RIPK41.44077023
31EIF2AK11.43131910
32SGK21.39736321
33NEK61.38346811
34ERBB31.38148333
35TSSK61.32598135
36CDK191.30505099
37CDK31.29676686
38TGFBR11.23406124
39STK241.22978942
40OXSR11.22971959
41PASK1.20966719
42PNCK1.20791911
43MAPK131.20609269
44STK31.19274169
45NTRK21.18022883
46GRK11.17733548
47CHEK21.15450806
48MAP3K41.11055858
49STK161.10591202
50TAOK31.10419814
51RAF11.08221998
52PBK1.06212195
53GRK71.05552757
54MAP4K21.05114140
55STK38L1.04651971
56LATS11.04635384
57CLK11.04498334
58NLK1.03445365
59SGK2231.02958352
60SGK4941.02958352
61PLK31.02448829
62WNK41.02293315
63TXK1.02149422
64BCR1.01980256
65EIF2AK31.00033280
66NEK10.97306066
67YES10.96198427
68PDK20.94938191
69BRD40.94667548
70NME10.91429262
71TEC0.87778944
72CCNB10.86971762
73FGR0.86816254
74PRKCE0.84825275
75VRK10.84236870
76PLK10.81939043
77IRAK10.79823604
78ATR0.79461977
79ATM0.78026882
80CAMK2A0.77842338
81DAPK10.77837860
82PRKCG0.75739714
83PLK40.73520586
84MAP3K20.72857932
85FES0.72506502
86FGFR10.70626429
87NEK20.70289926
88DAPK20.70030301
89PTK2B0.69992524
90ADRBK20.69497860
91FGFR20.68085285
92PDK30.68022827
93PDK40.68022827
94SRPK10.67674091
95PIM20.66450081
96IRAK40.63710631
97DYRK1A0.62544963
98MARK30.62134250
99MAP3K60.61022582
100PRKCQ0.60012547
101PINK10.59260255
102CAMKK20.58933236
103IKBKE0.58177483
104CAMK2B0.57614104
105SGK10.56494799
106EIF2AK20.56205315
107TLK10.55880301
108JAK30.55670023
109TRPM70.53076432
110STK390.52808856
111SGK30.51027763
112MARK10.50239340
113CHEK10.49361886
114MAP3K70.49293434
115CSNK1G20.48886443
116PIK3CG0.48216656
117PAK30.48183498
118RPS6KB10.48148917
119FGFR30.46357180
120MAPK70.46130331
121MINK10.46009055
122FLT30.45577911
123TAOK10.44276285
124IKBKB0.42459964
125CSNK1G10.42208446
126OBSCN0.42137118
127MAPKAPK50.41822704
128INSRR0.41215046
129KSR10.41065730
130RPS6KB20.40344874
131CSNK1E0.40059413
132BRSK10.39705683
133CDK80.39464871
134CDK10.38826522
135CSNK2A20.38220056
136AURKB0.37746263
137ERBB40.36532577
138CAMK2D0.34837597
139SCYL20.34455780
140IRAK20.33300292
141CSNK1A10.32906304
142MAP2K40.32762407
143WEE10.32201259
144CSNK1D0.32187995
145RPS6KA50.31821218
146TTK0.30315178
147CDK50.29537155
148PRKG10.29253071
149PKN10.28884295

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.18840195
2One carbon pool by folate_Homo sapiens_hsa006702.88317530
3Collecting duct acid secretion_Homo sapiens_hsa049662.61060383
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56498977
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36701053
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.28408305
7RNA polymerase_Homo sapiens_hsa030202.27432937
8Butanoate metabolism_Homo sapiens_hsa006502.23683558
9Propanoate metabolism_Homo sapiens_hsa006402.16396398
10Rheumatoid arthritis_Homo sapiens_hsa053232.11668904
11Glutamatergic synapse_Homo sapiens_hsa047242.06498860
12Nitrogen metabolism_Homo sapiens_hsa009102.01061065
13RNA transport_Homo sapiens_hsa030131.98233720
14DNA replication_Homo sapiens_hsa030301.96425325
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94039610
16Circadian entrainment_Homo sapiens_hsa047131.91391730
17Serotonergic synapse_Homo sapiens_hsa047261.87892091
18GABAergic synapse_Homo sapiens_hsa047271.86215561
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85334367
20Oxidative phosphorylation_Homo sapiens_hsa001901.84970602
21Morphine addiction_Homo sapiens_hsa050321.83042845
22Synaptic vesicle cycle_Homo sapiens_hsa047211.82540737
23Taste transduction_Homo sapiens_hsa047421.78216137
24Vitamin B6 metabolism_Homo sapiens_hsa007501.73151728
25Selenocompound metabolism_Homo sapiens_hsa004501.70412279
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.69325939
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62370902
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60336431
29Sphingolipid metabolism_Homo sapiens_hsa006001.58719497
30Ribosome_Homo sapiens_hsa030101.58216568
31Basal transcription factors_Homo sapiens_hsa030221.57843856
32Allograft rejection_Homo sapiens_hsa053301.56288005
33Cell cycle_Homo sapiens_hsa041101.54357109
34Graft-versus-host disease_Homo sapiens_hsa053321.53817916
35Proteasome_Homo sapiens_hsa030501.53394472
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49609711
37Phototransduction_Homo sapiens_hsa047441.47988724
38Type I diabetes mellitus_Homo sapiens_hsa049401.47161842
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.47055875
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46913912
41Amphetamine addiction_Homo sapiens_hsa050311.43578767
42Long-term potentiation_Homo sapiens_hsa047201.43140828
43Autoimmune thyroid disease_Homo sapiens_hsa053201.40479608
44Non-homologous end-joining_Homo sapiens_hsa034501.38234077
45African trypanosomiasis_Homo sapiens_hsa051431.35403676
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34897331
47Circadian rhythm_Homo sapiens_hsa047101.32969173
48Long-term depression_Homo sapiens_hsa047301.29790094
49mRNA surveillance pathway_Homo sapiens_hsa030151.29649652
50Fanconi anemia pathway_Homo sapiens_hsa034601.28024684
51Steroid biosynthesis_Homo sapiens_hsa001001.22300900
52Calcium signaling pathway_Homo sapiens_hsa040201.19946049
53Alzheimers disease_Homo sapiens_hsa050101.18892531
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17228761
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16694757
56RNA degradation_Homo sapiens_hsa030181.15570164
57Lysine degradation_Homo sapiens_hsa003101.15162227
58Vibrio cholerae infection_Homo sapiens_hsa051101.11354849
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09177624
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07500697
61Huntingtons disease_Homo sapiens_hsa050161.04030850
62Vitamin digestion and absorption_Homo sapiens_hsa049771.02104648
63Dopaminergic synapse_Homo sapiens_hsa047281.01526971
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01185159
65Parkinsons disease_Homo sapiens_hsa050121.00365210
66Olfactory transduction_Homo sapiens_hsa047400.99388988
67Tryptophan metabolism_Homo sapiens_hsa003800.99383408
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98992244
69Nucleotide excision repair_Homo sapiens_hsa034200.97607397
70Salivary secretion_Homo sapiens_hsa049700.97218798
71Ether lipid metabolism_Homo sapiens_hsa005650.97113897
72ABC transporters_Homo sapiens_hsa020100.96053532
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95631824
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.90145737
75Pyruvate metabolism_Homo sapiens_hsa006200.89700284
76Homologous recombination_Homo sapiens_hsa034400.89301851
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.88091008
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87371473
79Purine metabolism_Homo sapiens_hsa002300.86916024
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.84941722
81Regulation of autophagy_Homo sapiens_hsa041400.84002261
82Renin secretion_Homo sapiens_hsa049240.82741847
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82123673
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81666161
85Systemic lupus erythematosus_Homo sapiens_hsa053220.81272834
86Mismatch repair_Homo sapiens_hsa034300.81133791
87Retinol metabolism_Homo sapiens_hsa008300.80839731
88Linoleic acid metabolism_Homo sapiens_hsa005910.78647594
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77727888
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77540796
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77422186
92Protein export_Homo sapiens_hsa030600.74647208
93Tuberculosis_Homo sapiens_hsa051520.73268551
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70456925
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70221989
96p53 signaling pathway_Homo sapiens_hsa041150.69732844
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67460120
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67220213
99Oocyte meiosis_Homo sapiens_hsa041140.67122162
100Hematopoietic cell lineage_Homo sapiens_hsa046400.66673718
101Peroxisome_Homo sapiens_hsa041460.65165338
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.64210942
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63584259
104Chemical carcinogenesis_Homo sapiens_hsa052040.63464099
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.63174022
106Glycerolipid metabolism_Homo sapiens_hsa005610.62997964
107Caffeine metabolism_Homo sapiens_hsa002320.62411506
108Primary immunodeficiency_Homo sapiens_hsa053400.62120117
109Influenza A_Homo sapiens_hsa051640.62005240
110TGF-beta signaling pathway_Homo sapiens_hsa043500.60087487
111Phagosome_Homo sapiens_hsa041450.59780664
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58894984
113Asthma_Homo sapiens_hsa053100.55988756
114Cholinergic synapse_Homo sapiens_hsa047250.55575092
115Fatty acid elongation_Homo sapiens_hsa000620.55392939
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54589993
117Fatty acid biosynthesis_Homo sapiens_hsa000610.54160953
118Fructose and mannose metabolism_Homo sapiens_hsa000510.53568650
119Measles_Homo sapiens_hsa051620.53364428
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53316703
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53314531
122Malaria_Homo sapiens_hsa051440.53002337
123Mineral absorption_Homo sapiens_hsa049780.52883092
124Metabolic pathways_Homo sapiens_hsa011000.52247749
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52099917
126Pyrimidine metabolism_Homo sapiens_hsa002400.50553920
127Oxytocin signaling pathway_Homo sapiens_hsa049210.50216870
128Gastric acid secretion_Homo sapiens_hsa049710.49677611
129Insulin secretion_Homo sapiens_hsa049110.49336442
130Cocaine addiction_Homo sapiens_hsa050300.49335719
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48833166
132cAMP signaling pathway_Homo sapiens_hsa040240.44549613
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44080731
134Herpes simplex infection_Homo sapiens_hsa051680.43919823
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42452451
136Spliceosome_Homo sapiens_hsa030400.42378412
137beta-Alanine metabolism_Homo sapiens_hsa004100.42378231
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42357763
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39928277
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39870798
141Hedgehog signaling pathway_Homo sapiens_hsa043400.39400051
142Base excision repair_Homo sapiens_hsa034100.39188436
143Alcoholism_Homo sapiens_hsa050340.38686669
144Basal cell carcinoma_Homo sapiens_hsa052170.37725436
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37181106
146Epstein-Barr virus infection_Homo sapiens_hsa051690.36012886
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34332424
148Axon guidance_Homo sapiens_hsa043600.32495087
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29398252
150Arachidonic acid metabolism_Homo sapiens_hsa005900.29164432
151Fatty acid metabolism_Homo sapiens_hsa012120.28963422
152Type II diabetes mellitus_Homo sapiens_hsa049300.23422387
153Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23247787
154MicroRNAs in cancer_Homo sapiens_hsa052060.19910694
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19098985
156Fat digestion and absorption_Homo sapiens_hsa049750.16405441
157Drug metabolism - other enzymes_Homo sapiens_hsa009830.15451682
158Fatty acid degradation_Homo sapiens_hsa000710.15235680

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