ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	eosinophil chemotaxis (GO:0048245)	9.27165471
2	regulation of sister chromatid cohesion (GO:0007063)	9.09461020
3	negative regulation of T cell receptor signaling pathway (GO:0050860)	8.62481584
4	branch elongation of an epithelium (GO:0060602)	8.58424022
5	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	8.50816451
6	eosinophil migration (GO:0072677)	8.37385129
7	regulation of mononuclear cell migration (GO:0071675)	8.10297137
8	positive regulation of chromosome segregation (GO:0051984)	7.56286693
9	vesicle fusion (GO:0006906)	7.23499612
10	L-fucose catabolic process (GO:0042355)	7.11172563
11	fucose catabolic process (GO:0019317)	7.11172563
12	L-fucose metabolic process (GO:0042354)	7.11172563
13	peptidyl-lysine dimethylation (GO:0018027)	6.87670607
14	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	6.83628417
15	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	6.74652127
16	ribosomal small subunit assembly (GO:0000028)	6.35282458
17	axis elongation (GO:0003401)	6.34916777
18	autophagic vacuole fusion (GO:0000046)	6.12682577
19	coenzyme A biosynthetic process (GO:0015937)	5.94987456
20	organ growth (GO:0035265)	5.94888331
21	macrophage chemotaxis (GO:0048246)	5.81780974
22	negative regulation of circadian rhythm (GO:0042754)	5.62425011
23	localization within membrane (GO:0051668)	5.51259246
24	positive regulation of calcium ion import (GO:0090280)	5.47869421
25	protein import into peroxisome matrix (GO:0016558)	5.38355336
26	negative regulation of GTPase activity (GO:0034260)	5.24019294
27	negative regulation of GTP catabolic process (GO:0033125)	5.24019294
28	regulation of beta-amyloid formation (GO:1902003)	5.22064672
29	establishment of mitotic spindle orientation (GO:0000132)	5.13062860
30	regulation of T cell receptor signaling pathway (GO:0050856)	5.00521959
31	organelle membrane fusion (GO:0090174)	4.98763292
32	oxidative demethylation (GO:0070989)	4.98273219
33	regulation of autophagic vacuole assembly (GO:2000785)	4.98047195
34	sodium-independent organic anion transport (GO:0043252)	4.96611251
35	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	4.95094573
36	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.76979392
37	monocyte chemotaxis (GO:0002548)	4.76543327
38	establishment of spindle orientation (GO:0051294)	4.63488987
39	establishment of mitotic spindle localization (GO:0040001)	4.54978154
40	double-strand break repair via nonhomologous end joining (GO:0006303)	4.35173935
41	non-recombinational repair (GO:0000726)	4.35173935
42	histone H3-K9 methylation (GO:0051567)	4.26223580
43	branching involved in mammary gland duct morphogenesis (GO:0060444)	4.25266397
44	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.21162420
45	organelle fusion (GO:0048284)	4.15666684
46	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	4.09056339
47	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.08137059
48	regulation of vacuole organization (GO:0044088)	4.01032206
49	pantothenate metabolic process (GO:0015939)	3.94200575
50	positive chemotaxis (GO:0050918)	3.89612252
51	negative regulation of macroautophagy (GO:0016242)	3.86853830
52	regulation of stem cell maintenance (GO:2000036)	3.79156964
53	acrosome assembly (GO:0001675)	3.78880171
54	fucose metabolic process (GO:0006004)	3.77259136
55	3-UTR-mediated mRNA stabilization (GO:0070935)	3.76520357
56	seminiferous tubule development (GO:0072520)	3.74781037
57	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.73387425
58	fucosylation (GO:0036065)	3.67740863
59	membrane budding (GO:0006900)	3.59465100
60	single-organism membrane fusion (GO:0044801)	3.51641539
61	regulation of calcium ion import (GO:0090279)	3.51516095
62	early endosome to late endosome transport (GO:0045022)	3.47078790
63	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	3.46111353
64	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.45838027
65	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.45838027
66	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.45838027
67	negative regulation of purine nucleotide catabolic process (GO:0033122)	3.45450175
68	establishment of spindle localization (GO:0051293)	3.44514263
69	protein targeting to lysosome (GO:0006622)	3.43977646
70	establishment of protein localization to vacuole (GO:0072666)	3.43977646
71	protein targeting to vacuole (GO:0006623)	3.43977646
72	histone H3-K9 modification (GO:0061647)	3.41132080
73	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	3.41070372
74	Golgi transport vesicle coating (GO:0048200)	3.37990867
75	COPI coating of Golgi vesicle (GO:0048205)	3.37990867
76	coenzyme A metabolic process (GO:0015936)	3.34155244
77	ER to Golgi vesicle-mediated transport (GO:0006888)	3.31463683
78	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.28565836
79	negative regulation of nucleotide catabolic process (GO:0030812)	3.27495544
80	vesicle targeting (GO:0006903)	3.24822108
81	protein localization to peroxisome (GO:0072662)	3.24183638
82	protein targeting to peroxisome (GO:0006625)	3.24183638
83	establishment of protein localization to peroxisome (GO:0072663)	3.24183638
84	imidazole-containing compound metabolic process (GO:0052803)	3.24141218
85	negative regulation of nucleoside metabolic process (GO:0045978)	3.22781950
86	DNA integration (GO:0015074)	3.20265434
87	hair cycle (GO:0042633)	3.19415209
88	molting cycle (GO:0042303)	3.19415209
89	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.17228369
90	DNA demethylation (GO:0080111)	3.14439342
91	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14356848
92	preassembly of GPI anchor in ER membrane (GO:0016254)	3.04910807
93	regulation of cellular amide metabolic process (GO:0034248)	3.04652837
94	peroxisomal transport (GO:0043574)	2.95188457
95	protein prenylation (GO:0018342)	11.6168920
96	prenylation (GO:0097354)	11.6168920
97	negative regulation of Ras GTPase activity (GO:0034261)	11.2396568
98	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	11.2247429
99	positive regulation of mitotic sister chromatid separation (GO:1901970)	11.2247429
100	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	11.2247429

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	9.38947057
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.98047416
3	VDR_22108803_ChIP-Seq_LS180_Human	6.29559063
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.87512144
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.78747512
6	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.51840151
7	AR_21572438_ChIP-Seq_LNCaP_Human	2.84874943
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50917295
9	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.39385359
10	RXR_22108803_ChIP-Seq_LS180_Human	2.33587344
11	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.28801362
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.27902954
13	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.07224395
14	BCAT_22108803_ChIP-Seq_LS180_Human	2.03535436
15	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.00137741
16	ZNF263_19887448_ChIP-Seq_K562_Human	1.98299640
17	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.80045738
18	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.66787570
19	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.64402504
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61829411
21	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.61486432
22	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.61009348
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.60896162
24	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.59153081
25	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.57908943
26	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.57784581
27	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.54634309
28	AHR_22903824_ChIP-Seq_MCF-7_Human	1.52374839
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47470713
30	GATA3_26560356_Chip-Seq_TH1_Human	1.44547445
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43243696
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43243696
33	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.43098141
34	TP53_16413492_ChIP-PET_HCT116_Human	1.42370917
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36450865
36	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.34368286
37	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32691255
38	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.25823314
39	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.22367959
40	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.21841375
41	ZNF274_21170338_ChIP-Seq_K562_Hela	1.19887698
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.18895509
43	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.18310057
44	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16292509
45	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.15267132
46	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.15267132
47	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.15267132
48	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.13157962
49	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.12300022
50	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.10339737
51	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09956618
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06243487
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06077568
54	FUS_26573619_Chip-Seq_HEK293_Human	1.03926396
55	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.01829980
56	RUNX_20019798_ChIP-Seq_JUKART_Human	1.01559286
57	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96278980
58	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95432616
59	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.94802779
60	CBP_21632823_ChIP-Seq_H3396_Human	0.93216537
61	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.91229007
62	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.89936157
63	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.88715169
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.88651588
65	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.88522045
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88096837
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88096837
68	CDX2_22108803_ChIP-Seq_LS180_Human	0.86963279
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.86754129
70	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85674480
71	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.85177933
72	CBP_20019798_ChIP-Seq_JUKART_Human	0.84974997
73	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.84974997
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.84071992
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.82675097
76	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.80942868
77	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.79925492
78	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.78239011
79	TP53_22573176_ChIP-Seq_HFKS_Human	0.77678879
80	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.77200426
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.76768267
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.76695181
83	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.75859134
84	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.75798723
85	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.75698706
86	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.75635864
87	GATA4_25053715_ChIP-Seq_YYC3_Human	0.75374657
88	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.75250392
89	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.75248736
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.74608998
91	P300_19829295_ChIP-Seq_ESCs_Human	0.74280979
92	GATA2_19941826_ChIP-Seq_K562_Human	0.74069635
93	TCF4_23295773_ChIP-Seq_U87_Human	0.73595838
94	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.73341838
95	AR_25329375_ChIP-Seq_VCAP_Human	0.73272818
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.73268481
97	DROSHA_22980978_ChIP-Seq_HELA_Human	0.72785714
98	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.72418063
99	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.70442282
100	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.70124966

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	7.86955948
2	MP0006082_CNS_inflammation	4.65853835
3	MP0004381_abnormal_hair_follicle	3.47946179
4	MP0001919_abnormal_reproductive_system	3.04851971
5	MP0002751_abnormal_autonomic_nervous	2.74928740
6	MP0001663_abnormal_digestive_system	2.69777631
7	MP0000467_abnormal_esophagus_morphology	2.60936910
8	MP0000383_abnormal_hair_follicle	2.60000815
9	MP0001664_abnormal_digestion	2.52593600
10	MP0005646_abnormal_pituitary_gland	2.46616194
11	MP0005645_abnormal_hypothalamus_physiol	2.34047828
12	MP0000566_synostosis	10.9311998
13	MP0005389_reproductive_system_phenotype	1.95102859
14	MP0001485_abnormal_pinna_reflex	1.94582321
15	MP0005381_digestive/alimentary_phenotyp	1.91895378
16	MP0009697_abnormal_copulation	1.90893932
17	MP0009780_abnormal_chondrocyte_physiolo	1.90396941
18	MP0008995_early_reproductive_senescence	1.85273483
19	MP0000465_gastrointestinal_hemorrhage	1.78355785
20	MP0010678_abnormal_skin_adnexa	1.75354777
21	MP0002876_abnormal_thyroid_physiology	1.67339062
22	MP0008004_abnormal_stomach_pH	1.56586690
23	MP0003115_abnormal_respiratory_system	1.54692013
24	MP0008057_abnormal_DNA_replication	1.47503298
25	MP0002282_abnormal_trachea_morphology	1.45807550
26	MP0000534_abnormal_ureter_morphology	1.45206248
27	MP0003937_abnormal_limbs/digits/tail_de	1.44628407
28	MP0002254_reproductive_system_inflammat	1.43957270
29	MP0003724_increased_susceptibility_to	1.37887177
30	MP0000427_abnormal_hair_cycle	1.35832800
31	MP0005166_decreased_susceptibility_to	1.34495304
32	MP0003878_abnormal_ear_physiology	1.33261925
33	MP0005377_hearing/vestibular/ear_phenot	1.33261925
34	MP0003763_abnormal_thymus_physiology	1.31188075
35	MP0003868_abnormal_feces_composition	1.26618839
36	MP0001915_intracranial_hemorrhage	1.16545775
37	MP0000377_abnormal_hair_follicle	1.10597994
38	MP0001963_abnormal_hearing_physiology	1.09632179
39	MP0000372_irregular_coat_pigmentation	1.08730460
40	MP0002009_preneoplasia	1.08468936
41	MP0004043_abnormal_pH_regulation	0.99322888
42	MP0003638_abnormal_response/metabolism_	0.98086390
43	MP0006072_abnormal_retinal_apoptosis	0.96635447
44	MP0000490_abnormal_crypts_of	0.94336457
45	MP0000026_abnormal_inner_ear	0.93877743
46	MP0003453_abnormal_keratinocyte_physiol	0.92373949
47	MP0005508_abnormal_skeleton_morphology	0.90149080
48	MP0000358_abnormal_cell_content/	0.89864385
49	MP0002115_abnormal_skeleton_extremities	0.85996244
50	MP0003786_premature_aging	0.85471664
51	MP0003942_abnormal_urinary_system	0.84008168
52	MP0003279_aneurysm	0.79562386
53	MP0000470_abnormal_stomach_morphology	0.79381153
54	MP0000477_abnormal_intestine_morphology	0.78917720
55	MP0002277_abnormal_respiratory_mucosa	0.77681460
56	MP0004147_increased_porphyrin_level	0.77502608
57	MP0010155_abnormal_intestine_physiology	0.76195772
58	MP0002160_abnormal_reproductive_system	0.74748188
59	MP0000428_abnormal_craniofacial_morphol	0.73436335
60	MP0005076_abnormal_cell_differentiation	0.73274709
61	MP0004885_abnormal_endolymph	0.73035830
62	MP0002736_abnormal_nociception_after	0.72807696
63	MP0000627_abnormal_mammary_gland	0.71361862
64	MP0002109_abnormal_limb_morphology	0.68707212
65	MP0002019_abnormal_tumor_incidence	0.68307290
66	MP0008872_abnormal_physiological_respon	0.66852654
67	MP0005253_abnormal_eye_physiology	0.66365854
68	MP0001873_stomach_inflammation	0.64318199
69	MP0010030_abnormal_orbit_morphology	0.64157003
70	MP0001293_anophthalmia	0.62682707
71	MP0003045_fibrosis	0.61855581
72	MP0002113_abnormal_skeleton_development	0.60759887
73	MP0001764_abnormal_homeostasis	0.60724849
74	MP0005501_abnormal_skin_physiology	0.57628379
75	MP0003936_abnormal_reproductive_system	0.56964690
76	MP0005397_hematopoietic_system_phenotyp	0.56018316
77	MP0001545_abnormal_hematopoietic_system	0.56018316
78	MP0000858_altered_metastatic_potential	0.55732211
79	MP0000163_abnormal_cartilage_morphology	0.55011296
80	MP0002168_other_aberrant_phenotype	0.54551250
81	MP0001501_abnormal_sleep_pattern	0.54493591
82	MP0001286_abnormal_eye_development	0.53573794
83	MP0008875_abnormal_xenobiotic_pharmacok	0.53258493
84	MP0002210_abnormal_sex_determination	0.52280170
85	MP0004484_altered_response_of	0.52098901
86	MP0001666_abnormal_nutrient_absorption	0.49862548
87	MP0000432_abnormal_head_morphology	0.49593099
88	MP0010307_abnormal_tumor_latency	0.49380153
89	MP0003329_amyloid_beta_deposits	0.48526409
90	MP0000613_abnormal_salivary_gland	0.47488522
91	MP0005647_abnormal_sex_gland	0.47336136
92	MP0005275_abnormal_skin_tensile	0.46935770
93	MP0005310_abnormal_salivary_gland	0.46838478
94	MP0009763_increased_sensitivity_to	0.46102973
95	MP0005197_abnormal_uvea_morphology	0.46022646
96	MP0002108_abnormal_muscle_morphology	0.45713491
97	MP0001881_abnormal_mammary_gland	0.42935871
98	MP0003938_abnormal_ear_development	0.42646153
99	MP0001175_abnormal_lung_morphology	0.41900819
100	MP0003195_calcinosis	0.40982259

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	9.73933398
2	Duplicated collecting system (HP:0000081)	7.64408922
3	Pulmonary artery stenosis (HP:0004415)	7.04115786
4	Long foot (HP:0001833)	6.89680392
5	Abnormality of the renal collecting system (HP:0004742)	6.89649615
6	Acute lymphatic leukemia (HP:0006721)	5.65177088
7	Large for gestational age (HP:0001520)	5.34042323
8	Hypoplastic pelvis (HP:0008839)	5.16926006
9	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	5.15072472
10	Brushfield spots (HP:0001088)	4.92139627
11	Adactyly (HP:0009776)	4.84886891
12	Dry hair (HP:0011359)	4.62016808
13	Autoamputation (HP:0001218)	4.61923408
14	Abnormality of fatty-acid metabolism (HP:0004359)	4.60805802
15	Progressive muscle weakness (HP:0003323)	4.56944072
16	Abnormality of the epiphyses of the hand (HP:0005924)	4.38550553
17	Steatorrhea (HP:0002570)	4.26952800
18	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	4.10556431
19	Ureteral duplication (HP:0000073)	4.06110198
20	Hypoplastic nipples (HP:0002557)	3.94195816
21	Spontaneous abortion (HP:0005268)	3.84723524
22	Reduced subcutaneous adipose tissue (HP:0003758)	3.83606306
23	Severe muscular hypotonia (HP:0006829)	3.77838986
24	Ureteral stenosis (HP:0000071)	3.70146083
25	Epiphyseal stippling (HP:0010655)	3.67510350
26	Increased number of teeth (HP:0011069)	3.60626719
27	Broad nasal tip (HP:0000455)	3.58206650
28	Abnormal auditory evoked potentials (HP:0006958)	3.57173408
29	Ureteral obstruction (HP:0006000)	3.54842422
30	Menstrual irregularities (HP:0000858)	3.47229322
31	Fat malabsorption (HP:0002630)	3.42234974
32	Anhidrosis (HP:0000970)	3.39387565
33	Generalized amyotrophy (HP:0003700)	3.37015891
34	Broad-based gait (HP:0002136)	3.21507834
35	Sudden death (HP:0001699)	3.05309728
36	Polymicrogyria (HP:0002126)	3.04579879
37	Concave nail (HP:0001598)	3.00949551
38	Abnormal ventriculo-arterial connection (HP:0011563)	2.92517731
39	Transposition of the great arteries (HP:0001669)	2.92517731
40	Abnormal connection of the cardiac segments (HP:0011545)	2.92517731
41	Palmoplantar hyperkeratosis (HP:0000972)	2.81713051
42	Chronic hepatic failure (HP:0100626)	2.74261937
43	Flat face (HP:0012368)	2.63180434
44	Palmar hyperkeratosis (HP:0010765)	2.62584447
45	Decreased lacrimation (HP:0000633)	2.62570479
46	Wide intermamillary distance (HP:0006610)	2.61964807
47	Short hallux (HP:0010109)	2.57845356
48	Sparse lateral eyebrow (HP:0005338)	2.51982482
49	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.50990068
50	Small epiphyses (HP:0010585)	2.50548723
51	Abnormal tarsal ossification (HP:0008369)	2.48947874
52	Absent toe (HP:0010760)	2.48407965
53	Polyneuropathy (HP:0001271)	2.47490551
54	Steppage gait (HP:0003376)	2.46065391
55	Abnormal epiphyseal ossification (HP:0010656)	2.43036008
56	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.34447785
57	Decreased muscle mass (HP:0003199)	2.32037751
58	Clubbing of toes (HP:0100760)	2.31027361
59	Abnormality of vision evoked potentials (HP:0000649)	2.28561746
60	Chronic sinusitis (HP:0011109)	2.28162314
61	Plantar hyperkeratosis (HP:0007556)	2.18261758
62	Chorioretinal coloboma (HP:0000567)	2.17269690
63	Aqueductal stenosis (HP:0002410)	2.15997921
64	Abnormal pancreas size (HP:0012094)	2.15806077
65	Myoglobinuria (HP:0002913)	2.11793558
66	Widely spaced teeth (HP:0000687)	2.07983675
67	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.06797336
68	Abnormal cartilage morphology (HP:0002763)	2.04722906
69	Hypoplastic iliac wings (HP:0002866)	2.04352850
70	Basal ganglia calcification (HP:0002135)	2.04082606
71	Female pseudohermaphroditism (HP:0010458)	2.02932908
72	Large hands (HP:0001176)	1.98793631
73	Hyporeflexia of lower limbs (HP:0002600)	1.98115575
74	Gangrene (HP:0100758)	1.91442985
75	Lip pit (HP:0100267)	1.89069523
76	Hypothermia (HP:0002045)	1.86919657
77	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.81122657
78	Hyperlipoproteinemia (HP:0010980)	1.77037023
79	Recurrent bronchitis (HP:0002837)	1.76404361
80	Carpal bone hypoplasia (HP:0001498)	1.72728811
81	Deep philtrum (HP:0002002)	1.69974368
82	Arterial thrombosis (HP:0004420)	1.68112540
83	Flat capital femoral epiphysis (HP:0003370)	1.68054622
84	External ear malformation (HP:0008572)	1.67752615
85	Alveolar cell carcinoma (HP:0006519)	1.67128712
86	Thickened nuchal skin fold (HP:0000474)	1.65676623
87	Purpura (HP:0000979)	1.64388101
88	Large eyes (HP:0001090)	1.63556283
89	Prenatal maternal abnormality (HP:0002686)	1.62286655
90	Preauricular pit (HP:0004467)	1.60270569
91	Periauricular skin pits (HP:0100277)	1.60270569
92	Posterior embryotoxon (HP:0000627)	1.60202696
93	Abnormality of nail color (HP:0100643)	1.57992877
94	Abnormality of the line of Schwalbe (HP:0008048)	1.57313492
95	Dyschromatopsia (HP:0007641)	1.54564464
96	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.54313147
97	Stereotypic behavior (HP:0000733)	1.53962787
98	Rhabdomyolysis (HP:0003201)	1.53798932
99	Neoplasm of the tracheobronchial system (HP:0100552)	1.52970776
100	Overfolded helix (HP:0000396)	1.51796426

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.19598950
2	TAOK2	4.78150387
3	TAOK1	4.63200403
4	MAP3K11	3.99872655
5	MAP3K3	3.43283762
6	MAP2K3	3.26158905
7	MST4	3.23178269
8	STK39	3.11060931
9	OXSR1	2.42952142
10	EIF2AK3	2.02461080
11	MKNK2	10.7868228
12	JAK3	1.99548702
13	ABL2	1.68049904
14	FER	1.62476253
15	MAP3K5	1.52528964
16	DYRK1A	1.49554428
17	PAK3	1.23087917
18	MAP3K1	0.97351254
19	PRKCI	0.92297302
20	MAP3K12	0.87952193
21	SRPK1	0.86213137
22	STK24	0.73215739
23	STK10	0.69742519
24	MAP3K8	0.68002597
25	CHEK2	0.59705246
26	EEF2K	0.58836707
27	FGFR1	0.57260909
28	AKT3	0.55392103
29	PRKCQ	0.55289208
30	INSRR	0.54408438
31	PINK1	0.49517696
32	BMPR2	0.45979548
33	MAPKAPK3	0.40787212
34	PTK2	0.37963318
35	EPHA3	0.35685508
36	MAP2K1	0.33295106
37	ABL1	0.32725333
38	CASK	0.30166361
39	JAK1	0.29827153
40	SGK2	0.28209338
41	FRK	0.26746997
42	GRK1	0.24017788
43	LRRK2	0.23932458
44	PIK3CG	0.23746082
45	AKT2	0.23628601
46	MAPKAPK5	0.23074572
47	TNK2	0.21463808
48	IGF1R	0.18152674
49	IKBKE	0.17323409
50	MELK	0.16809086
51	TLK1	0.16373230
52	BMX	0.13938182
53	SGK3	0.13663507
54	SGK223	0.12430533
55	SGK494	0.12430533
56	TRPM7	0.11589261
57	ADRBK1	0.09702906
58	CSNK1A1	0.09022922
59	RPS6KB2	0.08460642
60	PHKG2	0.08353474
61	PHKG1	0.08353474
62	PRKCE	0.06256275
63	AURKA	0.04692440
64	WEE1	0.03982358
65	TEC	0.03860872
66	IRAK1	0.02490961
67	GRK5	0.01567312
68	RPS6KB1	0.01218047
69	RPS6KA2	0.01114152
70	CSNK2A2	0.01048688
71	CSNK1E	0.00550496
72	CHUK	0.00434666
73	WNK3	-0.0793798
74	SGK1	-0.0767903
75	PLK2	-0.0759920
76	EGFR	-0.0738353
77	MUSK	-0.0730970
78	PRKACA	-0.0727966
79	EPHB1	-0.0686459
80	NEK6	-0.0637578
81	SRC	-0.0621547
82	ERBB3	-0.0610402
83	PRKCA	-0.0579962
84	PRKD1	-0.0546542
85	IKBKB	-0.0517949
86	ADRBK2	-0.0506541
87	MATK	-0.0485460
88	BRSK2	-0.0475861
89	BMPR1B	-0.0473531
90	MYLK	-0.0454099
91	CSNK2A1	-0.0324506
92	GSK3A	-0.0314369
93	WNK4	-0.0301815
94	TIE1	-0.0280671
95	OBSCN	-0.0127358
96	PAK1	-0.0073481
97	ACVR1B	-0.0065258
98	GRK7	-0.0048159
99	MAPK13	-0.0044903
100	PRKCD	-0.0002915

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	7.31993494
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	5.89521148
3	Fatty acid elongation_Homo sapiens_hsa00062	3.54950508
4	RNA polymerase_Homo sapiens_hsa03020	3.33511768
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.03591631
6	Proteasome_Homo sapiens_hsa03050	3.03527962
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.78078858
8	Lysine degradation_Homo sapiens_hsa00310	2.62553426
9	Butanoate metabolism_Homo sapiens_hsa00650	2.56993354
10	Taste transduction_Homo sapiens_hsa04742	2.48973382
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.08450325
12	Peroxisome_Homo sapiens_hsa04146	1.95246972
13	One carbon pool by folate_Homo sapiens_hsa00670	1.85411889
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.81183746
15	beta-Alanine metabolism_Homo sapiens_hsa00410	1.70057888
16	Propanoate metabolism_Homo sapiens_hsa00640	1.57701713
17	Glycerolipid metabolism_Homo sapiens_hsa00561	1.56881011
18	Caffeine metabolism_Homo sapiens_hsa00232	1.36815740
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.34767655
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.25021581
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.19916762
22	Amoebiasis_Homo sapiens_hsa05146	1.19521368
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12709672
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12240986
25	Fatty acid degradation_Homo sapiens_hsa00071	1.10017879
26	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.04965397
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03569560
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.01233490
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99185156
30	Linoleic acid metabolism_Homo sapiens_hsa00591	0.98474499
31	Protein export_Homo sapiens_hsa03060	0.95236392
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.92490896
33	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89662708
34	Glutathione metabolism_Homo sapiens_hsa00480	0.89088667
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84918529
36	Folate biosynthesis_Homo sapiens_hsa00790	0.81438419
37	Pancreatic secretion_Homo sapiens_hsa04972	0.79304605
38	Complement and coagulation cascades_Homo sapiens_hsa04610	0.78949934
39	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.77499944
40	Phototransduction_Homo sapiens_hsa04744	0.74491955
41	Retinol metabolism_Homo sapiens_hsa00830	0.73251222
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70852274
43	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70475572
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.68887978
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.61893006
46	TNF signaling pathway_Homo sapiens_hsa04668	0.61204578
47	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.61099853
48	Salivary secretion_Homo sapiens_hsa04970	0.57169852
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52307519
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.52165894
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51748171
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51464683
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.51330273
54	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51313801
55	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.51013233
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50446965
57	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47798116
58	Viral myocarditis_Homo sapiens_hsa05416	0.46980875
59	AMPK signaling pathway_Homo sapiens_hsa04152	0.46714977
60	MicroRNAs in cancer_Homo sapiens_hsa05206	0.45532925
61	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.45292784
62	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.41280146
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.39661136
64	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39406405
65	Olfactory transduction_Homo sapiens_hsa04740	0.38635151
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38084922
67	ABC transporters_Homo sapiens_hsa02010	0.35466095
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33268914
69	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.33023906
70	Mineral absorption_Homo sapiens_hsa04978	0.32532713
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.31886907
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.31421432
73	Asthma_Homo sapiens_hsa05310	0.30428582
74	Metabolic pathways_Homo sapiens_hsa01100	0.28663639
75	RNA transport_Homo sapiens_hsa03013	0.25661334
76	Huntingtons disease_Homo sapiens_hsa05016	0.25258473
77	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.24557213
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24258878
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.21845554
80	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.18737747
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.18522405
82	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.18286956
83	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.17953951
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.17760892
85	Protein digestion and absorption_Homo sapiens_hsa04974	0.17525231
86	Cholinergic synapse_Homo sapiens_hsa04725	0.16821581
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.16451293
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.15503227
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.15137900
90	Nucleotide excision repair_Homo sapiens_hsa03420	0.13799605
91	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.13306257
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.13182761
93	Sulfur metabolism_Homo sapiens_hsa00920	0.12249967
94	Purine metabolism_Homo sapiens_hsa00230	0.11942663
95	Nicotine addiction_Homo sapiens_hsa05033	0.11474119
96	ECM-receptor interaction_Homo sapiens_hsa04512	0.11247580
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.10533750
98	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.10130976
99	Malaria_Homo sapiens_hsa05144	0.09613543
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.08875312

TMEM161BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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