TMEM163

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.30770531
2central nervous system myelination (GO:0022010)7.30770531
3myelination (GO:0042552)5.66826846
4axon ensheathment (GO:0008366)5.64384376
5ensheathment of neurons (GO:0007272)5.64384376
6fatty acid elongation (GO:0030497)5.59975862
7pyrimidine nucleobase catabolic process (GO:0006208)4.99432774
8behavioral response to nicotine (GO:0035095)4.96145981
9synaptic vesicle maturation (GO:0016188)4.75402874
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73754944
11neuron cell-cell adhesion (GO:0007158)4.72293710
12negative regulation of neurotransmitter secretion (GO:0046929)4.66136191
13presynaptic membrane assembly (GO:0097105)4.57522233
14cholesterol biosynthetic process (GO:0006695)4.53117636
15long-chain fatty acid biosynthetic process (GO:0042759)4.49066276
16substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.45313762
17substrate-independent telencephalic tangential migration (GO:0021826)4.45313762
18response to hepatocyte growth factor (GO:0035728)4.44721210
19cellular response to hepatocyte growth factor stimulus (GO:0035729)4.44721210
20substantia nigra development (GO:0021762)4.44665759
21response to redox state (GO:0051775)4.40007343
22transmission of nerve impulse (GO:0019226)4.28378230
23activated T cell proliferation (GO:0050798)4.26214655
24locomotory exploration behavior (GO:0035641)4.15005999
25presynaptic membrane organization (GO:0097090)4.14892840
26nucleobase catabolic process (GO:0046113)4.08842517
27L-amino acid import (GO:0043092)4.04488879
28negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.04356932
29regulation of collateral sprouting (GO:0048670)4.01950772
30auditory behavior (GO:0031223)3.98691648
31mitochondrion transport along microtubule (GO:0047497)3.97736543
32establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.97736543
33cellular response to epinephrine stimulus (GO:0071872)3.97127532
34oligodendrocyte differentiation (GO:0048709)3.95859152
35negative regulation of axon extension (GO:0030517)3.89415977
36sterol biosynthetic process (GO:0016126)3.88498153
37negative regulation of neurotransmitter transport (GO:0051589)3.86510263
38photoreceptor cell differentiation (GO:0046530)3.83413636
39eye photoreceptor cell differentiation (GO:0001754)3.83413636
40regulation of synapse structural plasticity (GO:0051823)3.81906966
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80991171
42amino acid import (GO:0043090)3.79101931
43myelination in peripheral nervous system (GO:0022011)3.77189542
44peripheral nervous system axon ensheathment (GO:0032292)3.77189542
45adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.67704620
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.67278936
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.65641549
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.64863727
49neuronal ion channel clustering (GO:0045161)3.61801269
50glycerophospholipid catabolic process (GO:0046475)3.60356694
51mechanosensory behavior (GO:0007638)3.59167296
52response to epinephrine (GO:0071871)3.58824121
53neurofilament cytoskeleton organization (GO:0060052)3.58371661
54cell migration in hindbrain (GO:0021535)3.56315411
55positive regulation of actin filament depolymerization (GO:0030836)3.51966176
56cerebellar Purkinje cell differentiation (GO:0021702)3.49942368
57negative regulation of axonogenesis (GO:0050771)3.45519546
58glutamate secretion (GO:0014047)3.43650700
59regulation of glutamate receptor signaling pathway (GO:1900449)3.41118031
60regulation of microtubule-based movement (GO:0060632)3.35626838
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35146864
62synapse assembly (GO:0007416)3.32663227
63regulation of synaptic vesicle transport (GO:1902803)3.31474105
64protein localization to synapse (GO:0035418)3.30466600
65positive regulation of gastrulation (GO:2000543)3.28166994
66isoprenoid biosynthetic process (GO:0008299)3.27415968
67neural nucleus development (GO:0048857)3.26896180
68neuron recognition (GO:0008038)3.24262890
69asymmetric protein localization (GO:0008105)3.24239183
70neuronal action potential propagation (GO:0019227)3.23213206
71neurotransmitter-gated ion channel clustering (GO:0072578)3.20118851
72Rap protein signal transduction (GO:0032486)3.19079430
73positive regulation of neurological system process (GO:0031646)3.19012746
74regulation of cilium movement (GO:0003352)3.18797944
75regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.18200604
76parturition (GO:0007567)3.17978887
77dendritic spine morphogenesis (GO:0060997)3.17615674
78apical protein localization (GO:0045176)3.16005290
79negative regulation of cytosolic calcium ion concentration (GO:0051481)3.14545112
80synaptic transmission, glutamatergic (GO:0035249)3.14025559
81cerebellar granule cell differentiation (GO:0021707)3.13597772
82protein palmitoylation (GO:0018345)3.10496915
83limb bud formation (GO:0060174)3.09297444
84positive regulation of growth hormone secretion (GO:0060124)3.09187927
85peptidyl-tyrosine autophosphorylation (GO:0038083)3.09157830
86long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.08160526
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08009053
88positive regulation of action potential (GO:0045760)3.06178993
89behavioral response to ethanol (GO:0048149)3.03515513
90ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.02834820
91neuron-neuron synaptic transmission (GO:0007270)3.00002034
92regulation of synaptic vesicle exocytosis (GO:2000300)2.99725403
93axonal fasciculation (GO:0007413)2.98467824
94brain morphogenesis (GO:0048854)2.96931232
95negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94368328
96positive regulation of neurotransmitter transport (GO:0051590)2.91641529
97cerebral cortex radially oriented cell migration (GO:0021799)2.91387950
98dendrite morphogenesis (GO:0048813)2.91322579
99cellular response to monoamine stimulus (GO:0071868)2.90409955
100cellular response to catecholamine stimulus (GO:0071870)2.90409955
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.88806618
102adult walking behavior (GO:0007628)2.88797514
103positive regulation of meiosis (GO:0045836)2.87929945
104nucleotide transmembrane transport (GO:1901679)2.87548094
105neurotransmitter secretion (GO:0007269)2.87535683
106axon extension (GO:0048675)2.87478576
107protein polyglutamylation (GO:0018095)2.86978307
108glutamate receptor signaling pathway (GO:0007215)2.84174502
109creatine metabolic process (GO:0006600)2.83655074
110positive regulation of oligodendrocyte differentiation (GO:0048714)2.83619631
111magnesium ion transport (GO:0015693)2.83122439
112response to methylmercury (GO:0051597)2.81902554
113spinal cord association neuron differentiation (GO:0021527)2.81732182
114regulation of female receptivity (GO:0045924)2.81306425
115astrocyte development (GO:0014002)2.79631408
116vocalization behavior (GO:0071625)2.79229891
117neuron maturation (GO:0042551)2.78247720
118response to auditory stimulus (GO:0010996)2.76322310
119tachykinin receptor signaling pathway (GO:0007217)2.76097397
120adhesion of symbiont to host cell (GO:0044650)2.75484913
121virion attachment to host cell (GO:0019062)2.75484913
122regulation of neurotransmitter secretion (GO:0046928)2.75224847
123forebrain neuron differentiation (GO:0021879)2.74244171
124regulation of calcium ion-dependent exocytosis (GO:0017158)2.74211503
125long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.72774131
126response to catecholamine (GO:0071869)2.72146363
127response to monoamine (GO:0071867)2.72146363
128membrane depolarization during action potential (GO:0086010)2.71989011
129cranial nerve development (GO:0021545)2.71428886
130neuron remodeling (GO:0016322)2.71424766
131import into cell (GO:0098657)2.70811400
132regulation of neuronal synaptic plasticity (GO:0048168)2.69347142
133myelin maintenance (GO:0043217)2.69346639
134exploration behavior (GO:0035640)2.68370468
135negative regulation of catecholamine secretion (GO:0033604)2.67955495
136negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66749735
137G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65876211
138establishment of mitochondrion localization (GO:0051654)2.65805828
139response to lipoprotein particle (GO:0055094)2.64640957
140negative regulation of axon guidance (GO:1902668)2.64414806
141neuromuscular synaptic transmission (GO:0007274)2.63821883
142regulation of neurotransmitter transport (GO:0051588)2.63333506
143negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62757563
144retinal ganglion cell axon guidance (GO:0031290)2.62151485
145positive regulation of meiotic cell cycle (GO:0051446)2.61048922
146cell differentiation in hindbrain (GO:0021533)2.60883060
147regulation of synaptic transmission, glutamatergic (GO:0051966)2.58497115
148positive regulation of dendritic spine development (GO:0060999)2.57944883
149microtubule bundle formation (GO:0001578)2.57736466
150positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57480043
151dopamine receptor signaling pathway (GO:0007212)2.57141353
152negative regulation of protein localization to cell surface (GO:2000009)2.56893609
153fatty-acyl-CoA biosynthetic process (GO:0046949)2.56245372
154gamma-aminobutyric acid transport (GO:0015812)2.55856060
155striatum development (GO:0021756)2.53394053
156membrane repolarization (GO:0086009)2.52657630
157synaptic transmission, dopaminergic (GO:0001963)2.50548579
158gamma-aminobutyric acid signaling pathway (GO:0007214)2.50254127
159nerve growth factor signaling pathway (GO:0038180)2.49249816
160positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.48857952
161negative regulation of interleukin-10 production (GO:0032693)2.48018046
162synaptic vesicle exocytosis (GO:0016079)2.44855118
163negative regulation of axon extension involved in axon guidance (GO:0048843)2.44306571
164peripheral nervous system development (GO:0007422)2.44146702
165semaphorin-plexin signaling pathway (GO:0071526)2.43856483
166postsynaptic membrane organization (GO:0001941)2.43306876
167regulation of myelination (GO:0031641)2.42153715
168ER overload response (GO:0006983)2.41783702
169positive regulation of synapse assembly (GO:0051965)2.40966116
170neurotransmitter catabolic process (GO:0042135)2.40704101
171ionotropic glutamate receptor signaling pathway (GO:0035235)2.39538469
172synapse organization (GO:0050808)2.39101425
173regulation of transmission of nerve impulse (GO:0051969)2.38818371
174spinal cord motor neuron differentiation (GO:0021522)2.37944057
175regulation of extent of cell growth (GO:0061387)2.35703910
176membrane assembly (GO:0071709)2.34819293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.66552805
2GBX2_23144817_ChIP-Seq_PC3_Human3.45649720
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61376382
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55135218
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52346749
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41529874
7TAF15_26573619_Chip-Seq_HEK293_Human2.38002210
8* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.35703668
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.33254377
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11854291
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10606832
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10606832
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.09566400
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09086260
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07736903
16AR_21572438_ChIP-Seq_LNCaP_Human2.05166132
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05113889
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04887315
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03673090
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98106036
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97799322
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95439121
23* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95322922
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92702622
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91395630
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90433318
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89944159
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89283628
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.89117677
30DROSHA_22980978_ChIP-Seq_HELA_Human1.88786342
31* RNF2_27304074_Chip-Seq_ESCs_Mouse1.88757016
32* REST_21632747_ChIP-Seq_MESCs_Mouse1.85615338
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83289203
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80231770
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77531395
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74028325
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63172122
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62271755
39P300_19829295_ChIP-Seq_ESCs_Human1.59983101
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.58979490
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.58922314
42* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54062476
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52719071
44ER_23166858_ChIP-Seq_MCF-7_Human1.52453120
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50726353
46VDR_22108803_ChIP-Seq_LS180_Human1.49280234
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.47010322
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44116050
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43040907
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42918193
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.42717235
52* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41047066
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39974348
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36837892
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36159362
56FUS_26573619_Chip-Seq_HEK293_Human1.34957932
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31546160
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.29859860
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29614037
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.28810042
61ZNF274_21170338_ChIP-Seq_K562_Hela1.28760794
62* RNF2_27304074_Chip-Seq_NSC_Mouse1.28066352
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25813203
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25512450
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25274368
66STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24313821
67* STAT3_23295773_ChIP-Seq_U87_Human1.24240400
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24108911
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24108911
70* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22770688
71* NANOG_18555785_Chip-Seq_ESCs_Mouse1.21020805
72LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20889777
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20542437
74* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16073532
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15313028
76TCF4_23295773_ChIP-Seq_U87_Human1.14049051
77* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13807680
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12116476
79* RUNX2_22187159_ChIP-Seq_PCA_Human1.11987457
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11965302
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10043961
82* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09736148
83* CMYC_18555785_Chip-Seq_ESCs_Mouse1.09619473
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.08020622
85* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06732827
86* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02070816
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01495715
88* EP300_21415370_ChIP-Seq_HL-1_Mouse1.01312737
89IGF1R_20145208_ChIP-Seq_DFB_Human1.01069367
90TAL1_26923725_Chip-Seq_HPCs_Mouse0.99973133
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99528140
92* P53_22387025_ChIP-Seq_ESCs_Mouse0.98613966
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98240394
94* P300_18555785_Chip-Seq_ESCs_Mouse0.97723780
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97487343
96* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97136991
97ERG_21242973_ChIP-ChIP_JURKAT_Human0.96519949
98AHR_22903824_ChIP-Seq_MCF-7_Human0.96117491
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.95723637
100* RING1B_27294783_Chip-Seq_ESCs_Mouse0.95527314
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94991207
102ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94886702
103* RING1B_27294783_Chip-Seq_NPCs_Mouse0.94603832
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94438813
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94371875
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93751734
107* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93525117
108* E2F1_18555785_Chip-Seq_ESCs_Mouse0.93020963
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92912233
110IRF1_19129219_ChIP-ChIP_H3396_Human0.91442161
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.91438537
112SOX9_26525672_Chip-Seq_HEART_Mouse0.90872407
113AR_25329375_ChIP-Seq_VCAP_Human0.90493872
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.88374560
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88254140
116* TP53_22573176_ChIP-Seq_HFKS_Human0.88247102
117BP1_19119308_ChIP-ChIP_Hs578T_Human0.87720026
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86937070
119CBP_20019798_ChIP-Seq_JUKART_Human0.86937070
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.85697515
121AR_19668381_ChIP-Seq_PC3_Human0.84884090
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84316709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.38459395
2MP0000920_abnormal_myelination3.99281947
3MP0003123_paternal_imprinting3.13805749
4MP0004270_analgesia3.00017657
5MP0004742_abnormal_vestibular_system2.88842721
6MP0003690_abnormal_glial_cell2.67171490
7MP0001529_abnormal_vocalization2.61612700
8MP0002272_abnormal_nervous_system2.58112841
9MP0001486_abnormal_startle_reflex2.50065677
10MP0004859_abnormal_synaptic_plasticity2.47746280
11MP0002064_seizures2.45917728
12MP0008877_abnormal_DNA_methylation2.45264515
13MP0000778_abnormal_nervous_system2.43430548
14MP0003121_genomic_imprinting2.36230082
15MP0002822_catalepsy2.33040762
16MP0003635_abnormal_synaptic_transmissio2.33015920
17MP0000462_abnormal_digestive_system2.27865076
18MP0005171_absent_coat_pigmentation2.24166723
19MP0001485_abnormal_pinna_reflex2.20646559
20MP0004885_abnormal_endolymph2.20333292
21MP0001905_abnormal_dopamine_level2.16771615
22MP0009046_muscle_twitch2.16675790
23MP0003329_amyloid_beta_deposits2.14604202
24MP0009745_abnormal_behavioral_response2.10458151
25MP0005423_abnormal_somatic_nervous2.05891831
26MP0001440_abnormal_grooming_behavior2.00930752
27MP0002734_abnormal_mechanical_nocicepti2.00815166
28MP0003634_abnormal_glial_cell2.00631801
29MP0002572_abnormal_emotion/affect_behav1.91385705
30MP0005499_abnormal_olfactory_system1.88233635
31MP0005394_taste/olfaction_phenotype1.88233635
32MP0003879_abnormal_hair_cell1.82923733
33MP0004142_abnormal_muscle_tone1.82617344
34MP0004145_abnormal_muscle_electrophysio1.81271603
35MP0005409_darkened_coat_color1.78056493
36MP0002063_abnormal_learning/memory/cond1.73630249
37MP0006276_abnormal_autonomic_nervous1.72663125
38MP0008789_abnormal_olfactory_epithelium1.65597670
39MP0002067_abnormal_sensory_capabilities1.64189176
40MP0002229_neurodegeneration1.63502556
41MP0000955_abnormal_spinal_cord1.62622174
42MP0003890_abnormal_embryonic-extraembry1.61694388
43MP0003136_yellow_coat_color1.61417785
44MP0002882_abnormal_neuron_morphology1.57544385
45MP0002163_abnormal_gland_morphology1.49807239
46MP0002733_abnormal_thermal_nociception1.49591295
47MP0004134_abnormal_chest_morphology1.48341618
48MP0002876_abnormal_thyroid_physiology1.47210917
49MP0002184_abnormal_innervation1.46432833
50MP0003632_abnormal_nervous_system1.46277088
51MP0004043_abnormal_pH_regulation1.45406995
52MP0005551_abnormal_eye_electrophysiolog1.43082324
53MP0008569_lethality_at_weaning1.42391898
54MP0005386_behavior/neurological_phenoty1.41353348
55MP0004924_abnormal_behavior1.41353348
56MP0006292_abnormal_olfactory_placode1.40939994
57MP0001299_abnormal_eye_distance/1.40845912
58MP0006072_abnormal_retinal_apoptosis1.40806900
59MP0001968_abnormal_touch/_nociception1.38522513
60MP0001970_abnormal_pain_threshold1.37920396
61MP0002638_abnormal_pupillary_reflex1.37762080
62MP0002066_abnormal_motor_capabilities/c1.37722258
63MP0005645_abnormal_hypothalamus_physiol1.35622582
64MP0002557_abnormal_social/conspecific_i1.31906960
65MP0002735_abnormal_chemical_nociception1.31045586
66MP0001963_abnormal_hearing_physiology1.30466334
67MP0000566_synostosis1.28863059
68MP0002752_abnormal_somatic_nervous1.25327542
69MP0001986_abnormal_taste_sensitivity1.18267161
70MP0000631_abnormal_neuroendocrine_gland1.17791084
71MP0005379_endocrine/exocrine_gland_phen1.16641140
72MP0003195_calcinosis1.16493960
73MP0009780_abnormal_chondrocyte_physiolo1.13452241
74MP0003122_maternal_imprinting1.13018159
75MP0001502_abnormal_circadian_rhythm1.10486427
76MP0005253_abnormal_eye_physiology1.07463632
77MP0001984_abnormal_olfaction1.05050409
78MP0001501_abnormal_sleep_pattern1.04848636
79MP0005646_abnormal_pituitary_gland1.04293738
80MP0003950_abnormal_plasma_membrane1.01912850
81MP0002653_abnormal_ependyma_morphology1.00861783
82MP0008995_early_reproductive_senescence1.00852630
83MP0002152_abnormal_brain_morphology1.00534709
84MP0003283_abnormal_digestive_organ1.00124993
85MP0002160_abnormal_reproductive_system0.98771045
86MP0003011_delayed_dark_adaptation0.98736950
87MP0001661_extended_life_span0.97945349
88MP0005187_abnormal_penis_morphology0.96346734
89MP0002736_abnormal_nociception_after0.96307753
90MP0000026_abnormal_inner_ear0.94901367
91MP0002909_abnormal_adrenal_gland0.93725077
92MP0003631_nervous_system_phenotype0.93050352
93MP0002928_abnormal_bile_duct0.92450869
94MP0002090_abnormal_vision0.91525341
95MP0005195_abnormal_posterior_eye0.90921535
96MP0002693_abnormal_pancreas_physiology0.89167522
97MP0002751_abnormal_autonomic_nervous0.87518705
98MP0005310_abnormal_salivary_gland0.87456111
99MP0005410_abnormal_fertilization0.86421729
100MP0000604_amyloidosis0.85458372
101MP0004133_heterotaxia0.85379064
102MP0001177_atelectasis0.83269013
103MP0003868_abnormal_feces_composition0.82478942
104MP0004811_abnormal_neuron_physiology0.82378494
105MP0000013_abnormal_adipose_tissue0.81349630
106MP0001919_abnormal_reproductive_system0.79549975
107MP0005389_reproductive_system_phenotype0.79241785
108MP0003172_abnormal_lysosome_physiology0.78532637
109MP0005535_abnormal_body_temperature0.78216816
110MP0003938_abnormal_ear_development0.77164547
111MP0010386_abnormal_urinary_bladder0.76458082
112MP0003137_abnormal_impulse_conducting0.76291767
113MP0003861_abnormal_nervous_system0.75700317
114MP0003633_abnormal_nervous_system0.75672343
115MP0002837_dystrophic_cardiac_calcinosis0.74422394
116MP0003937_abnormal_limbs/digits/tail_de0.74357989
117MP0000230_abnormal_systemic_arterial0.73395591
118MP0002938_white_spotting0.72847283
119MP0002069_abnormal_eating/drinking_beha0.72444040
120MP0004085_abnormal_heartbeat0.72055562
121MP0005451_abnormal_body_composition0.71471219
122MP0003787_abnormal_imprinting0.70762520
123MP0001188_hyperpigmentation0.69468238
124MP0002102_abnormal_ear_morphology0.69012820
125MP0005623_abnormal_meninges_morphology0.68409324
126MP0001756_abnormal_urination0.68185051
127MP0005084_abnormal_gallbladder_morpholo0.67958420
128MP0001944_abnormal_pancreas_morphology0.67539357
129MP0000427_abnormal_hair_cycle0.66654561
130MP0008872_abnormal_physiological_respon0.65753206
131MP0008775_abnormal_heart_ventricle0.62951689
132MP0005448_abnormal_energy_balance0.62746776

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.71080578
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.71080578
3Sensory axonal neuropathy (HP:0003390)5.26961186
4Neurofibrillary tangles (HP:0002185)4.91559190
5Abnormality of the corticospinal tract (HP:0002492)4.54883690
6Polyphagia (HP:0002591)4.46286047
7Agitation (HP:0000713)4.04111200
8Parakeratosis (HP:0001036)4.03283247
9Abnormal pancreas size (HP:0012094)3.97013306
10Atonic seizures (HP:0010819)3.88276296
11Peripheral hypomyelination (HP:0007182)3.52639214
12Cerebral inclusion bodies (HP:0100314)3.42007519
13Akinesia (HP:0002304)3.41629548
14Spastic gait (HP:0002064)3.33283819
15Abnormality of the parathyroid morphology (HP:0011766)3.32818472
16Supranuclear gaze palsy (HP:0000605)3.26141694
17Abnormal eating behavior (HP:0100738)3.14305622
18Alacrima (HP:0000522)3.05253124
19Gait imbalance (HP:0002141)3.04161665
20Medial flaring of the eyebrow (HP:0010747)3.02677453
21Intention tremor (HP:0002080)3.01507190
22Drooling (HP:0002307)2.97726516
23Small epiphyses (HP:0010585)2.95903862
24Pheochromocytoma (HP:0002666)2.92695624
25Neoplasm of the adrenal cortex (HP:0100641)2.91648362
26Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.88929859
27Hyperthyroidism (HP:0000836)2.87807874
28Nephronophthisis (HP:0000090)2.86102283
29Febrile seizures (HP:0002373)2.84653573
30Dysmetria (HP:0001310)2.78715831
31Abnormality of glycolysis (HP:0004366)2.76407718
32Increased serum pyruvate (HP:0003542)2.76407718
33Hepatoblastoma (HP:0002884)2.72641698
34Cerebral hypomyelination (HP:0006808)2.72246003
35Congenital stationary night blindness (HP:0007642)2.72020479
36Excessive salivation (HP:0003781)2.71023941
37Anteriorly placed anus (HP:0001545)2.68593334
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.67481576
39Increased circulating renin level (HP:0000848)2.63964566
40Scanning speech (HP:0002168)2.61444761
41Retinal dysplasia (HP:0007973)2.60754032
42Premature skin wrinkling (HP:0100678)2.60248085
43Molar tooth sign on MRI (HP:0002419)2.56928355
44Abnormality of midbrain morphology (HP:0002418)2.56928355
45Pachygyria (HP:0001302)2.55804832
46Neuroendocrine neoplasm (HP:0100634)2.55172207
47Impaired vibration sensation in the lower limbs (HP:0002166)2.52363094
48Cupped ear (HP:0000378)2.50292724
49Decreased lacrimation (HP:0000633)2.50183177
50Metaphyseal dysplasia (HP:0100255)2.49664720
51Abnormality of macular pigmentation (HP:0008002)2.44997136
52Leukodystrophy (HP:0002415)2.42227299
53Abnormality of the renal medulla (HP:0100957)2.40979394
54Congenital primary aphakia (HP:0007707)2.39481286
55Bony spicule pigmentary retinopathy (HP:0007737)2.38702755
56Spastic tetraplegia (HP:0002510)2.35382554
57Nephrogenic diabetes insipidus (HP:0009806)2.35051958
58Focal motor seizures (HP:0011153)2.33460530
59Epileptiform EEG discharges (HP:0011182)2.31911113
60Amyotrophic lateral sclerosis (HP:0007354)2.28049760
61Hemiparesis (HP:0001269)2.26973455
62Enlarged penis (HP:0000040)2.26731117
63Cerebral hemorrhage (HP:0001342)2.26196410
64EEG with generalized epileptiform discharges (HP:0011198)2.25740082
65Growth hormone deficiency (HP:0000824)2.24884267
66Renal Fanconi syndrome (HP:0001994)2.24283978
67Hypsarrhythmia (HP:0002521)2.22489784
68Termporal pattern (HP:0011008)2.21782139
69Insidious onset (HP:0003587)2.21782139
70Slow saccadic eye movements (HP:0000514)2.20028123
71Onion bulb formation (HP:0003383)2.19206150
72Urinary bladder sphincter dysfunction (HP:0002839)2.19159570
73Poor suck (HP:0002033)2.18233142
74Abnormality of the labia minora (HP:0012880)2.17299239
75Abnormal rod and cone electroretinograms (HP:0008323)2.17139761
76Anomalous pulmonary venous return (HP:0010772)2.16810485
77Fetal akinesia sequence (HP:0001989)2.16673861
78Generalized tonic-clonic seizures (HP:0002069)2.15908584
79Failure to thrive in infancy (HP:0001531)2.15734602
80True hermaphroditism (HP:0010459)2.15486578
81Genetic anticipation (HP:0003743)2.14721808
82Hypoplastic pelvis (HP:0008839)2.11927113
83Pancreatic fibrosis (HP:0100732)2.11763932
84Ankle clonus (HP:0011448)2.11566178
85Focal seizures (HP:0007359)2.11403772
86Myokymia (HP:0002411)2.09905696
87Abnormal drinking behavior (HP:0030082)2.09312271
88Polydipsia (HP:0001959)2.09312271
89Hypomagnesemia (HP:0002917)2.08730957
90Poor speech (HP:0002465)2.06861028
91Abnormality of calcium-phosphate metabolism (HP:0100530)2.05918333
92Oligodactyly (hands) (HP:0001180)2.05319236
93Lissencephaly (HP:0001339)2.05049969
94Action tremor (HP:0002345)2.04126342
95Acute necrotizing encephalopathy (HP:0006965)2.03922803
96Hypogonadotrophic hypogonadism (HP:0000044)2.03906956
97Deep palmar crease (HP:0006191)2.03685356
98Focal dystonia (HP:0004373)2.00270228
99Thickened helices (HP:0000391)1.99957778
100Thyroid-stimulating hormone excess (HP:0002925)1.97815235
101Broad-based gait (HP:0002136)1.97809641
102Lower limb muscle weakness (HP:0007340)1.97306693
103Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97296491
104Hypoplasia of the brainstem (HP:0002365)1.97296491
105Abnormal auditory evoked potentials (HP:0006958)1.97255844
106Epileptic encephalopathy (HP:0200134)1.96597986
107Progressive inability to walk (HP:0002505)1.96040222
108Sleep apnea (HP:0010535)1.95952006
109Tubular atrophy (HP:0000092)1.94423678
110Tubulointerstitial nephritis (HP:0001970)1.94336506
111Amblyopia (HP:0000646)1.93926466
112Clumsiness (HP:0002312)1.93718308
113Type II lissencephaly (HP:0007260)1.93346739
114Vaginal atresia (HP:0000148)1.92801336
115Restlessness (HP:0000711)1.92528437
116Torticollis (HP:0000473)1.91581628
117Widely spaced teeth (HP:0000687)1.91318064
118Progressive cerebellar ataxia (HP:0002073)1.91148498
119Congenital ichthyosiform erythroderma (HP:0007431)1.90664482
120Chronic hepatic failure (HP:0100626)1.90037481
121Synostosis involving the elbow (HP:0003938)1.89580075
122Humeroradial synostosis (HP:0003041)1.89580075
123Specific learning disability (HP:0001328)1.88714269
124Epiphyseal dysplasia (HP:0002656)1.88526336
125Absent septum pellucidum (HP:0001331)1.87867480
126Chin dimple (HP:0010751)1.87451363
127Dialeptic seizures (HP:0011146)1.86971026
128Hyperphosphatemia (HP:0002905)1.86290263
129Pancreatic cysts (HP:0001737)1.86184839
130Anxiety (HP:0000739)1.85456805
131Mixed hearing impairment (HP:0000410)1.83858243
132Genital tract atresia (HP:0001827)1.83478304
133White forelock (HP:0002211)1.82636772
134Limb dystonia (HP:0002451)1.82327473
135Adrenal hypoplasia (HP:0000835)1.81436105
136Autoamputation (HP:0001218)1.81216240
137Split foot (HP:0001839)1.81054425
138Abnormality of the pulmonary veins (HP:0011718)1.80278473
139Anosmia (HP:0000458)1.80249325
140Abnormality of the lower motor neuron (HP:0002366)1.79804103
141Bowel incontinence (HP:0002607)1.79722359
142Poor coordination (HP:0002370)1.79564652
143Abnormality of the renal cortex (HP:0011035)1.79383118
144Spastic paraparesis (HP:0002313)1.78959654
145Patchy hypopigmentation of hair (HP:0011365)1.78670710
146Septo-optic dysplasia (HP:0100842)1.78332403
147Blue irides (HP:0000635)1.77837875
148Gaze-evoked nystagmus (HP:0000640)1.77485973
149Congenital malformation of the right heart (HP:0011723)1.77358223
150Double outlet right ventricle (HP:0001719)1.77358223
151Clonus (HP:0002169)1.75603243
152Congenital sensorineural hearing impairment (HP:0008527)1.75523469
153Status epilepticus (HP:0002133)1.75484965
154Morphological abnormality of the pyramidal tract (HP:0002062)1.75459848
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75392360
1563-Methylglutaconic aciduria (HP:0003535)1.75346473
157Severe visual impairment (HP:0001141)1.74682571
158Abnormality of renin-angiotensin system (HP:0000847)1.74569368
159Abolished electroretinogram (ERG) (HP:0000550)1.73978521
160Abnormality of incisor morphology (HP:0011063)1.71941877
161Partial agenesis of the corpus callosum (HP:0001338)1.68994109
162Absent speech (HP:0001344)1.68494259
163Hyperventilation (HP:0002883)1.67740893
164Visual hallucinations (HP:0002367)1.67239985
165Decreased central vision (HP:0007663)1.66818834
166Absent/shortened dynein arms (HP:0200106)1.65964381
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.65964381
168Absence seizures (HP:0002121)1.65544907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.20862841
2TNIK4.57418296
3OXSR13.49866039
4EPHB13.14432159
5PINK12.85268146
6BCR2.84903631
7UHMK12.55528125
8WNK42.54434454
9DAPK22.50591190
10PKN12.43709062
11TYRO32.41799414
12CASK2.39880128
13FRK2.04639912
14MAPK132.01359915
15IRAK22.00837657
16ICK1.92527144
17MARK11.87844584
18LIMK11.81975985
19PRPF4B1.79359136
20NTRK11.79330087
21FES1.77984441
22ZAK1.70764694
23WNK11.68968975
24CDK191.62089822
25IRAK11.57384676
26FGFR21.49796432
27SGK21.48466611
28SIK21.47840911
29CSNK1G31.47107687
30NEK61.42845891
31NTRK31.37150823
32MET1.36962828
33INSRR1.34002221
34PNCK1.33545309
35ROCK21.32913911
36CSNK1A1L1.32148484
37PAK61.24035283
38IRAK41.23787530
39FGR1.20535166
40CAMKK11.19433477
41CSNK1G21.16464942
42CSNK1G11.14196568
43DYRK21.12877019
44MAP3K21.12450325
45PAK31.07834370
46MAP2K41.06625768
47MST41.05203061
48GRK11.05197978
49DYRK31.05112942
50CAMK2B1.04497821
51MAPK151.02990418
52CAMK2D1.01681354
53EPHA41.00707308
54BRAF0.89503837
55SGK30.89252646
56CDK50.88585739
57PRKCQ0.86932521
58CLK10.85802199
59NTRK20.85223890
60SGK4940.80791099
61SGK2230.80791099
62PBK0.80501405
63CAMK2A0.79429712
64AKT30.78497834
65RPS6KA20.78338060
66TAOK30.74950072
67MAP3K110.73496804
68HIPK20.72761577
69TIE10.70271080
70ROCK10.69572118
71CDK140.68074165
72PRKCE0.67988724
73MINK10.67934192
74MAP3K40.67770669
75FYN0.67655678
76WNK30.67240684
77PLK20.66500945
78MARK20.66023208
79EPHB20.64728588
80PDGFRB0.63563851
81PRKCZ0.61059407
82MAP2K70.60461657
83PRKD30.56982706
84CSNK1E0.56353860
85PRKCH0.55882124
86TRIM280.54987381
87CAMK2G0.54511835
88MAP3K90.52172672
89LMTK20.51680481
90MAPKAPK50.50573384
91GRK50.50427496
92CDK150.49321764
93PTK20.49146808
94CSK0.49131131
95MAP3K60.49008006
96CAMK10.48886600
97SGK10.48871659
98CDK180.48528339
99ADRBK10.47783098
100ADRBK20.46507013
101PHKG20.46305578
102PHKG10.46305578
103BMPR1B0.46287963
104GSK3A0.46284619
105NUAK10.45227747
106ERBB40.45190387
107PDPK10.44643513
108PRKG10.44567197
109ARAF0.44246087
110TNK20.43928086
111CDC42BPA0.43856934
112PRKACA0.43071578
113OBSCN0.42841822
114CDK11A0.42741302
115CAMK1G0.41009640
116KSR10.40753510
117PRKCG0.40735514
118INSR0.40268957
119CSNK1A10.40182730
120DYRK1B0.39812715
121EPHA30.38910564
122BMPR20.38589495
123STK160.38251925
124BRD40.38077336
125DYRK1A0.37803971
126PRKCA0.37089408
127GRK70.36749051
128CAMKK20.36234000
129RPS6KA30.35486604
130ITK0.35343748
131ABL20.35022992
132MAP3K130.34751574
133CSNK1D0.34232582
134DMPK0.34088360
135KSR20.33616200
136PRKD10.32443794
137MUSK0.30858034
138STK110.28632738

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.83604790
2Steroid biosynthesis_Homo sapiens_hsa001004.00434657
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28820827
4Fatty acid elongation_Homo sapiens_hsa000622.74019434
5Protein export_Homo sapiens_hsa030602.49437676
6Ether lipid metabolism_Homo sapiens_hsa005652.46625890
7Oxidative phosphorylation_Homo sapiens_hsa001902.28972050
8Axon guidance_Homo sapiens_hsa043602.12625797
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.04157638
10Collecting duct acid secretion_Homo sapiens_hsa049662.02588867
11Sulfur metabolism_Homo sapiens_hsa009202.01438315
12Serotonergic synapse_Homo sapiens_hsa047261.88715446
13Glutamatergic synapse_Homo sapiens_hsa047241.87113922
14Vibrio cholerae infection_Homo sapiens_hsa051101.81999956
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72958429
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70479318
17Synaptic vesicle cycle_Homo sapiens_hsa047211.67876120
18GABAergic synapse_Homo sapiens_hsa047271.66788898
19Alzheimers disease_Homo sapiens_hsa050101.61877011
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.61140397
21Nicotine addiction_Homo sapiens_hsa050331.60506087
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56974179
23Sphingolipid metabolism_Homo sapiens_hsa006001.55775470
24Long-term depression_Homo sapiens_hsa047301.49260091
25Cholinergic synapse_Homo sapiens_hsa047251.44810338
26Parkinsons disease_Homo sapiens_hsa050121.42789757
27Morphine addiction_Homo sapiens_hsa050321.40621822
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29241681
29Insulin secretion_Homo sapiens_hsa049111.28368122
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28215834
31Dopaminergic synapse_Homo sapiens_hsa047281.27127219
32Circadian entrainment_Homo sapiens_hsa047131.25990794
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24790285
34Butanoate metabolism_Homo sapiens_hsa006501.24495664
35Renal cell carcinoma_Homo sapiens_hsa052111.12058537
36Cocaine addiction_Homo sapiens_hsa050301.08281306
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07969647
38Taste transduction_Homo sapiens_hsa047421.03574148
39Long-term potentiation_Homo sapiens_hsa047201.02552144
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02400663
41Cardiac muscle contraction_Homo sapiens_hsa042601.02145469
42Amphetamine addiction_Homo sapiens_hsa050310.98258213
43Rheumatoid arthritis_Homo sapiens_hsa053230.96677522
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96561648
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95193127
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91314741
47Type II diabetes mellitus_Homo sapiens_hsa049300.89799859
48Salivary secretion_Homo sapiens_hsa049700.87973616
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87933405
50Huntingtons disease_Homo sapiens_hsa050160.82221246
51Pancreatic secretion_Homo sapiens_hsa049720.82025660
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.79528599
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.79188160
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74325651
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.73733490
56Dilated cardiomyopathy_Homo sapiens_hsa054140.73336682
57Renin secretion_Homo sapiens_hsa049240.72766617
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71965413
59Gastric acid secretion_Homo sapiens_hsa049710.71962613
60Phagosome_Homo sapiens_hsa041450.71080911
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70205788
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69829530
63Linoleic acid metabolism_Homo sapiens_hsa005910.69746553
64Ras signaling pathway_Homo sapiens_hsa040140.67716248
65Ovarian steroidogenesis_Homo sapiens_hsa049130.67471877
66Circadian rhythm_Homo sapiens_hsa047100.65816272
67ErbB signaling pathway_Homo sapiens_hsa040120.64795938
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64031970
69Oxytocin signaling pathway_Homo sapiens_hsa049210.63411334
70Bile secretion_Homo sapiens_hsa049760.63032863
71Gap junction_Homo sapiens_hsa045400.62056359
72Lysosome_Homo sapiens_hsa041420.61848014
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61174059
74Choline metabolism in cancer_Homo sapiens_hsa052310.60704664
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60092354
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58676447
77Tight junction_Homo sapiens_hsa045300.57927367
78Endocytosis_Homo sapiens_hsa041440.57774617
79Phototransduction_Homo sapiens_hsa047440.57098121
80Prion diseases_Homo sapiens_hsa050200.55396376
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54582003
82VEGF signaling pathway_Homo sapiens_hsa043700.53853026
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53517224
84Dorso-ventral axis formation_Homo sapiens_hsa043200.53446851
85cAMP signaling pathway_Homo sapiens_hsa040240.48814509
86Olfactory transduction_Homo sapiens_hsa047400.47632433
87Oocyte meiosis_Homo sapiens_hsa041140.47275624
88Basal transcription factors_Homo sapiens_hsa030220.46797756
89Autoimmune thyroid disease_Homo sapiens_hsa053200.46085680
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46004323
91Thyroid hormone synthesis_Homo sapiens_hsa049180.45887252
92GnRH signaling pathway_Homo sapiens_hsa049120.45692405
93Rap1 signaling pathway_Homo sapiens_hsa040150.45526607
94Fatty acid metabolism_Homo sapiens_hsa012120.44055579
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42869034
96Calcium signaling pathway_Homo sapiens_hsa040200.42570977
97Glucagon signaling pathway_Homo sapiens_hsa049220.41891563
98Alcoholism_Homo sapiens_hsa050340.41881654
99Estrogen signaling pathway_Homo sapiens_hsa049150.41481548
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.40499245
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39522580
102Type I diabetes mellitus_Homo sapiens_hsa049400.39246088
103Peroxisome_Homo sapiens_hsa041460.36648606
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36476965
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36293570
106MAPK signaling pathway_Homo sapiens_hsa040100.34836500
107T cell receptor signaling pathway_Homo sapiens_hsa046600.34522039
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34175360
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33870822
110Hedgehog signaling pathway_Homo sapiens_hsa043400.33636789
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33174646
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33117487
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31917872
114Regulation of autophagy_Homo sapiens_hsa041400.30821205
115Arginine and proline metabolism_Homo sapiens_hsa003300.30351874
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.30111779
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29507483
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29012325
119Tryptophan metabolism_Homo sapiens_hsa003800.28251377
120Melanogenesis_Homo sapiens_hsa049160.28107488
121Chemokine signaling pathway_Homo sapiens_hsa040620.27902576
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27456365
123Inositol phosphate metabolism_Homo sapiens_hsa005620.27061712
124Notch signaling pathway_Homo sapiens_hsa043300.26005081
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24143212

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