TMEM165

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skin morphogenesis (GO:0043589)4.03976661
2iron ion import (GO:0097286)3.99772513
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.95691470
4ribosomal small subunit assembly (GO:0000028)3.92122795
5hemidesmosome assembly (GO:0031581)3.84748565
6protein retention in ER lumen (GO:0006621)3.81053077
7viral transcription (GO:0019083)3.72513357
8peptidyl-proline hydroxylation (GO:0019511)3.69693331
9translational termination (GO:0006415)3.65777308
10hypotonic response (GO:0006971)3.55849528
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.49033466
12positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.47868507
13protein localization to endosome (GO:0036010)3.46981201
14protein targeting to ER (GO:0045047)3.42232681
15cotranslational protein targeting to membrane (GO:0006613)3.38969774
16protein hydroxylation (GO:0018126)3.32783650
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30599956
18DNA unwinding involved in DNA replication (GO:0006268)3.29884749
19barbed-end actin filament capping (GO:0051016)3.28759342
20establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26672065
21extracellular fibril organization (GO:0043206)3.23069010
22apoptotic cell clearance (GO:0043277)3.16729821
23translational elongation (GO:0006414)3.14806296
24membrane raft organization (GO:0031579)3.14397526
25protein localization to endoplasmic reticulum (GO:0070972)3.13967450
26fibril organization (GO:0097435)3.13443306
27surfactant homeostasis (GO:0043129)3.13139018
28collagen fibril organization (GO:0030199)3.08434098
29COPI coating of Golgi vesicle (GO:0048205)3.06711410
30Golgi transport vesicle coating (GO:0048200)3.06711410
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02549109
32cellular response to thyroid hormone stimulus (GO:0097067)3.01350050
33regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.01326572
34keratan sulfate catabolic process (GO:0042340)2.89085489
35UDP-N-acetylglucosamine metabolic process (GO:0006047)2.88070119
36cell-substrate junction assembly (GO:0007044)2.88040844
37regulation of protein heterodimerization activity (GO:0043497)2.86841656
38translational initiation (GO:0006413)2.86103248
39positive regulation of osteoblast proliferation (GO:0033690)2.85098424
40hyaluronan catabolic process (GO:0030214)2.84774984
41formation of translation preinitiation complex (GO:0001731)2.83899954
42neutrophil activation involved in immune response (GO:0002283)2.83476238
43import into cell (GO:0098657)2.83025297
44regulation of metalloenzyme activity (GO:0048552)2.82331201
45sequestering of extracellular ligand from receptor (GO:0035581)2.81253335
46viral life cycle (GO:0019058)2.81054236
47mesodermal cell differentiation (GO:0048333)2.78752171
48COPII vesicle coating (GO:0048208)2.77748105
49collagen metabolic process (GO:0032963)2.76809835
50mature B cell differentiation involved in immune response (GO:0002313)2.76200393
51Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75227147
52embryonic process involved in female pregnancy (GO:0060136)2.74540005
53folic acid-containing compound biosynthetic process (GO:0009396)2.74080936
54T cell apoptotic process (GO:0070231)2.72757127
55negative regulation of protein localization to plasma membrane (GO:1903077)2.72606832
56nuclear pore complex assembly (GO:0051292)2.71865205
573-UTR-mediated mRNA stabilization (GO:0070935)2.71843857
58endothelium development (GO:0003158)2.71051828
59wound healing, spreading of epidermal cells (GO:0035313)2.69186502
60response to thyroid hormone (GO:0097066)2.68897963
61maturation of SSU-rRNA (GO:0030490)2.67311235
62positive regulation of SMAD protein import into nucleus (GO:0060391)2.67276465
63membrane protein ectodomain proteolysis (GO:0006509)2.67041808
64cellular protein complex disassembly (GO:0043624)2.66628950
65extracellular matrix assembly (GO:0085029)2.66374551
66collagen catabolic process (GO:0030574)2.66144521
67desmosome organization (GO:0002934)2.65858201
68nuclear pore organization (GO:0006999)2.65720356
69extracellular matrix disassembly (GO:0022617)2.64252305
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62076087
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62076087
72pentose-phosphate shunt (GO:0006098)2.61470129
73protein maturation by protein folding (GO:0022417)2.60588373
74negative regulation of complement activation (GO:0045916)2.60221579
75cortical actin cytoskeleton organization (GO:0030866)2.60098443
76nucleobase-containing small molecule interconversion (GO:0015949)2.58407747
77retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57396348
78sequestering of metal ion (GO:0051238)2.55341364
79cell migration involved in heart development (GO:0060973)2.53737812
80regulation of SMAD protein import into nucleus (GO:0060390)2.53703937
81blood vessel maturation (GO:0001955)2.53675489
82multicellular organismal macromolecule metabolic process (GO:0044259)2.52891200
83regulation of glucocorticoid metabolic process (GO:0031943)2.52049565
84regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49554111
85type B pancreatic cell proliferation (GO:0044342)2.48433294
86IMP biosynthetic process (GO:0006188)2.47887684
87IMP metabolic process (GO:0046040)2.47693076
88positive regulation of endothelial cell apoptotic process (GO:2000353)2.47432662
89lymphocyte apoptotic process (GO:0070227)2.47283323
90ribosomal small subunit biogenesis (GO:0042274)2.47250676
91vascular endothelial growth factor signaling pathway (GO:0038084)2.46974277
92cellular response to vitamin (GO:0071295)2.46862481
93vesicle coating (GO:0006901)2.46563932
94DNA strand elongation involved in DNA replication (GO:0006271)2.45995723
952-deoxyribonucleotide biosynthetic process (GO:0009265)2.44222072
96deoxyribose phosphate biosynthetic process (GO:0046385)2.44222072
97dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44063565
98negative regulation of nitric oxide biosynthetic process (GO:0045019)2.42696701
99DNA replication initiation (GO:0006270)2.41614400
100multicellular organismal metabolic process (GO:0044236)2.40566012
101RNA stabilization (GO:0043489)2.40452995
102mRNA stabilization (GO:0048255)2.40452995
103multicellular organismal catabolic process (GO:0044243)2.40321621
104cyclooxygenase pathway (GO:0019371)2.39892126
105regulation of transforming growth factor beta1 production (GO:0032908)2.39232664
106positive regulation of blood vessel endothelial cell migration (GO:0043536)2.38289864
107endoplasmic reticulum unfolded protein response (GO:0030968)2.37677795
108protein complex disassembly (GO:0043241)2.37332118
109protein targeting to membrane (GO:0006612)2.36771114
110regulation of integrin-mediated signaling pathway (GO:2001044)2.36622906
111cellular response to vitamin D (GO:0071305)2.34311627
112protein N-linked glycosylation via asparagine (GO:0018279)2.33717194
113NADPH regeneration (GO:0006740)2.33686748
114mitotic nuclear envelope disassembly (GO:0007077)2.32949797
115phagocytosis, engulfment (GO:0006911)2.32699984
116protein localization to kinetochore (GO:0034501)2.32627143
117regulation of monocyte chemotaxis (GO:0090025)2.32342435
118DNA strand elongation (GO:0022616)2.31618953
119cortical cytoskeleton organization (GO:0030865)2.31172272
120peptidyl-asparagine modification (GO:0018196)2.30910211
121activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.30650765
122basement membrane organization (GO:0071711)2.30589494
123chemical homeostasis within a tissue (GO:0048875)2.29869979
124substrate-dependent cell migration (GO:0006929)2.29695044
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29577547
126antigen processing and presentation of endogenous antigen (GO:0019883)2.29091753
127positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28527553
128chondrocyte proliferation (GO:0035988)2.27930196
129negative regulation of smooth muscle cell migration (GO:0014912)2.27672333
130myeloid cell homeostasis (GO:0002262)2.27580664
131nucleotide-sugar biosynthetic process (GO:0009226)2.26950734
132regulation of translational fidelity (GO:0006450)2.26936618
133positive regulation of odontogenesis (GO:0042482)2.26791439
134negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.26743622
135regulation of necrotic cell death (GO:0010939)2.25621398
136positive regulation of receptor recycling (GO:0001921)2.25431462
137negative regulation of RNA splicing (GO:0033119)2.24993006
138zinc ion transmembrane transport (GO:0071577)2.24734793
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.24734630
140mammary gland epithelial cell proliferation (GO:0033598)2.24592836
141pinocytosis (GO:0006907)2.23601111
142positive regulation of nuclease activity (GO:0032075)2.22601064
143ER-nucleus signaling pathway (GO:0006984)2.22301446
144cellular response to zinc ion (GO:0071294)2.22200974
145regulation of mononuclear cell migration (GO:0071675)2.21972295
146negative regulation of cell fate specification (GO:0009996)2.21963951
147cell adhesion mediated by integrin (GO:0033627)2.21767898
148gland morphogenesis (GO:0022612)2.21668967
149ribosomal large subunit biogenesis (GO:0042273)2.21656934
150leukocyte apoptotic process (GO:0071887)2.20800707
151lipopolysaccharide biosynthetic process (GO:0009103)2.20578273
152telomere maintenance via semi-conservative replication (GO:0032201)2.20328375
153nuclear envelope disassembly (GO:0051081)2.19585258
154membrane disassembly (GO:0030397)2.19585258
155lipopolysaccharide metabolic process (GO:0008653)2.19153204
156B cell mediated immunity (GO:0019724)2.17173424
157macromolecular complex disassembly (GO:0032984)2.15787291
158DNA replication-dependent nucleosome organization (GO:0034723)2.15511954
159DNA replication-dependent nucleosome assembly (GO:0006335)2.15511954
160wound healing, spreading of cells (GO:0044319)2.14792499
161immunoglobulin mediated immune response (GO:0016064)2.14787057
162mRNA catabolic process (GO:0006402)2.13411202
163endodermal cell differentiation (GO:0035987)2.12729421
164morphogenesis of an endothelium (GO:0003159)2.12715215
165endothelial tube morphogenesis (GO:0061154)2.12715215
166antigen processing and presentation via MHC class Ib (GO:0002475)2.12574915
167regulation of RNA export from nucleus (GO:0046831)2.11751812
168pore complex assembly (GO:0046931)2.11445726
169response to interferon-alpha (GO:0035455)2.10287106
170RNA catabolic process (GO:0006401)2.09086530
171mitotic sister chromatid cohesion (GO:0007064)2.06819040
172response to peptidoglycan (GO:0032494)2.05912872
173negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.05133416
174positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.04973506
175definitive hemopoiesis (GO:0060216)2.04793439
176protein localization to chromosome, centromeric region (GO:0071459)2.04775359
177glucocorticoid receptor signaling pathway (GO:0042921)2.04195683
178corticosteroid receptor signaling pathway (GO:0031958)2.02897066
179neutrophil mediated immunity (GO:0002446)2.02660988
180telomere maintenance via recombination (GO:0000722)2.02092750
181negative regulation of mRNA splicing, via spliceosome (GO:0048025)1.99632393
182response to interferon-beta (GO:0035456)1.99601381
183polarized epithelial cell differentiation (GO:0030859)1.99547258
184negative regulation of phagocytosis (GO:0050765)1.97379392
185heterochromatin organization (GO:0070828)1.97311094
186maternal placenta development (GO:0001893)1.97237153
187modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.97029876
188modulation by symbiont of host immune response (GO:0052553)1.97029876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.46797570
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.11789651
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.15018455
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.07990534
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05101050
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.02093739
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.74745874
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73449170
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.70848495
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58029727
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28740719
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.25150196
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20187886
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.15783696
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09248127
16MYC_22102868_ChIP-Seq_BL_Human2.07445854
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05908346
18BRD4_25478319_ChIP-Seq_HGPS_Human2.04107931
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02891370
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.02175024
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94598173
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93987607
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.90126281
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88268255
25VDR_21846776_ChIP-Seq_THP-1_Human1.86799507
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84340204
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84281618
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81462262
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80614086
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79318603
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78658851
32AR_21909140_ChIP-Seq_LNCAP_Human1.78487731
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75051484
34GATA1_22025678_ChIP-Seq_K562_Human1.75017485
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63730068
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.63204448
37ELK1_19687146_ChIP-ChIP_HELA_Human1.62735200
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.62704079
39CLOCK_20551151_ChIP-Seq_293T_Human1.61036770
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58740818
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.57705169
42* SPI1_23547873_ChIP-Seq_NB4_Human1.57601258
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56015444
44XRN2_22483619_ChIP-Seq_HELA_Human1.55224425
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54780025
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53742457
47FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.53560864
48ZNF263_19887448_ChIP-Seq_K562_Human1.51444086
49SOX2_20726797_ChIP-Seq_SW620_Human1.50297332
50CJUN_26792858_Chip-Seq_BT549_Human1.48874430
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47534778
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47064274
53JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46213060
54* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44981683
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44699880
56VDR_24763502_ChIP-Seq_THP-1_Human1.44122679
57MYB_26560356_Chip-Seq_TH2_Human1.43055092
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.42762143
59TFEB_21752829_ChIP-Seq_HELA_Human1.42341714
60* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41566319
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.39832619
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39522537
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38871244
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38246174
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.36927343
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.35233986
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.34589638
68JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33540987
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33305096
70MAF_26560356_Chip-Seq_TH1_Human1.33037333
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32352480
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31688935
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31398751
74* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30753725
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30655094
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30655094
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.29301810
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29137962
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29091953
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27836249
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.27024487
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26909832
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26808455
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.26762107
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25753456
86DCP1A_22483619_ChIP-Seq_HELA_Human1.24902182
87* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24855624
88SCL_19346495_ChIP-Seq_HPC-7_Human1.23527733
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23506025
90VDR_23849224_ChIP-Seq_CD4+_Human1.23250839
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22697240
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22677907
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21885005
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21707295
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20826265
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20485811
97MYB_26560356_Chip-Seq_TH1_Human1.19920158
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19880189
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.19445444
100TCF7_22412390_ChIP-Seq_EML_Mouse1.18299887
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18266667
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17693277
103* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16450056
104UTX_26944678_Chip-Seq_JUKART_Human1.15392944
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15212589
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.14813045
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14750981
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14630399
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14182237
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.13487213
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13235149
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13119520
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12700617
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11928183
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10805835
116RACK7_27058665_Chip-Seq_MCF-7_Human1.10755601
117* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10490372
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10185831
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09992887
120BP1_19119308_ChIP-ChIP_Hs578T_Human1.09019453
121FOXO3_23340844_ChIP-Seq_DLD1_Human1.08517389
122ATF3_27146783_Chip-Seq_COLON_Human1.08468353
123RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07341548
124GATA1_19941826_ChIP-Seq_K562_Human1.06448204
125TTF2_22483619_ChIP-Seq_HELA_Human1.06222165
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05137863
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04073900
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04049441
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03939636
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03530912
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02983973
132TBX20_22080862_ChIP-Seq_HEART_Mouse1.02858266
133TBX20_22328084_ChIP-Seq_HEART_Mouse1.02858266
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02351957
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02351957
136ETS1_20019798_ChIP-Seq_JURKAT_Human1.02219014
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01826951
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01760678
139GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00652533
140TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99945360
141KDM5A_27292631_Chip-Seq_BREAST_Human0.97483342
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97116185
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.97041263
144KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96476088
145NCOR1_26117541_ChIP-Seq_K562_Human0.95198463
146* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95021116
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94805120
148CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88694784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps2.90586321
2MP0003705_abnormal_hypodermis_morpholog2.88605341
3MP0006054_spinal_hemorrhage2.83040607
4MP0008438_abnormal_cutaneous_collagen2.81031345
5MP0003303_peritoneal_inflammation2.54652093
6MP0003191_abnormal_cellular_cholesterol2.26042785
7MP0003950_abnormal_plasma_membrane2.21169248
8MP0002060_abnormal_skin_morphology1.95937066
9MP0004272_abnormal_basement_membrane1.90968494
10MP0005076_abnormal_cell_differentiation1.87412162
11MP0003566_abnormal_cell_adhesion1.87178208
12MP0005503_abnormal_tendon_morphology1.86942733
13MP0003300_gastrointestinal_ulcer1.85486573
14MP0003436_decreased_susceptibility_to1.80039850
15MP0003693_abnormal_embryo_hatching1.75028512
16MP0004957_abnormal_blastocyst_morpholog1.72307904
17MP0010234_abnormal_vibrissa_follicle1.72060948
18MP0000490_abnormal_crypts_of1.66818594
19MP0005165_increased_susceptibility_to1.63673603
20MP0001835_abnormal_antigen_presentation1.63220876
21MP0001881_abnormal_mammary_gland1.62874987
22MP0002396_abnormal_hematopoietic_system1.62577810
23MP0002877_abnormal_melanocyte_morpholog1.62331240
24MP0001542_abnormal_bone_strength1.56114092
25MP0004808_abnormal_hematopoietic_stem1.54198309
26MP0003123_paternal_imprinting1.53135223
27MP0009278_abnormal_bone_marrow1.52065286
28MP0010307_abnormal_tumor_latency1.47479772
29MP0005164_abnormal_response_to1.46817682
30MP0009840_abnormal_foam_cell1.45334959
31MP0003077_abnormal_cell_cycle1.45244679
32MP0005623_abnormal_meninges_morphology1.44131575
33MP0002796_impaired_skin_barrier1.43232044
34MP0000858_altered_metastatic_potential1.42407636
35MP0010368_abnormal_lymphatic_system1.41296753
36MP0000685_abnormal_immune_system1.41200651
37MP0003448_altered_tumor_morphology1.40156267
38MP0005275_abnormal_skin_tensile1.37077716
39MP0008004_abnormal_stomach_pH1.34742411
40MP0005023_abnormal_wound_healing1.33371629
41MP0009785_altered_susceptibility_to1.33208156
42MP0002148_abnormal_hypersensitivity_rea1.32984984
43MP0001958_emphysema1.32881862
44MP0005257_abnormal_intraocular_pressure1.30595561
45MP0002419_abnormal_innate_immunity1.30367648
46MP0000733_abnormal_muscle_development1.27556714
47MP0009333_abnormal_splenocyte_physiolog1.25325526
48MP0002166_altered_tumor_susceptibility1.24405975
49MP0003075_altered_response_to1.24016181
50MP0001545_abnormal_hematopoietic_system1.23511266
51MP0005397_hematopoietic_system_phenotyp1.23511266
52MP0000465_gastrointestinal_hemorrhage1.22866847
53MP0003279_aneurysm1.21506938
54MP0002452_abnormal_antigen_presenting1.20287106
55MP0002295_abnormal_pulmonary_circulatio1.19624871
56MP0008007_abnormal_cellular_replicative1.19200989
57MP0005000_abnormal_immune_tolerance1.18938330
58MP0004197_abnormal_fetal_growth/weight/1.18760804
59MP0002006_tumorigenesis1.18008688
60MP0001243_abnormal_dermal_layer1.17574148
61MP0000350_abnormal_cell_proliferation1.17114209
62MP0001533_abnormal_skeleton_physiology1.16893980
63MP0000537_abnormal_urethra_morphology1.15487782
64MP0001730_embryonic_growth_arrest1.15389310
65MP0005025_abnormal_response_to1.14776416
66MP0005508_abnormal_skeleton_morphology1.14726216
67MP0010094_abnormal_chromosome_stability1.12971936
68MP0002086_abnormal_extraembryonic_tissu1.11166827
69MP0005501_abnormal_skin_physiology1.09753237
70MP0003828_pulmonary_edema1.07963684
71MP0003111_abnormal_nucleus_morphology1.07045985
72MP0001915_intracranial_hemorrhage1.06837339
73MP0003724_increased_susceptibility_to1.06021084
74MP0003941_abnormal_skin_development1.05998141
75MP0002405_respiratory_system_inflammati1.04885935
76MP0003567_abnormal_fetal_cardiomyocyte1.04569969
77MP0004947_skin_inflammation1.04516530
78MP0001819_abnormal_immune_cell1.04417110
79MP0002420_abnormal_adaptive_immunity1.04411614
80MP0001853_heart_inflammation1.04078555
81MP0005621_abnormal_cell_physiology1.03455036
82MP0006082_CNS_inflammation1.03021336
83MP0003091_abnormal_cell_migration1.02153616
84MP0010155_abnormal_intestine_physiology1.01128872
85MP0005058_abnormal_lysosome_morphology0.99778726
86MP0001216_abnormal_epidermal_layer0.99027192
87MP0004264_abnormal_extraembryonic_tissu0.99020665
88MP0001293_anophthalmia0.98888605
89MP0002896_abnormal_bone_mineralization0.98823329
90MP0008260_abnormal_autophagy0.98681510
91MP0000627_abnormal_mammary_gland0.97858056
92MP0003984_embryonic_growth_retardation0.97626915
93MP0002398_abnormal_bone_marrow0.97351343
94MP0001873_stomach_inflammation0.96947439
95MP0002088_abnormal_embryonic_growth/wei0.96871330
96MP0000428_abnormal_craniofacial_morphol0.95778173
97MP0003186_abnormal_redox_activity0.95028306
98MP0004858_abnormal_nervous_system0.94980015
99MP0008057_abnormal_DNA_replication0.94683756
100MP0010386_abnormal_urinary_bladder0.94340640
101MP0002723_abnormal_immune_serum0.94140237
102MP0001849_ear_inflammation0.93704111
103MP0001697_abnormal_embryo_size0.93678892
104MP0003656_abnormal_erythrocyte_physiolo0.93140851
105MP0004782_abnormal_surfactant_physiolog0.93125938
106MP0002084_abnormal_developmental_patter0.93062825
107MP0008932_abnormal_embryonic_tissue0.92287681
108MP0003453_abnormal_keratinocyte_physiol0.91676196
109MP0000343_altered_response_to0.91511906
110MP0005380_embryogenesis_phenotype0.91125097
111MP0001672_abnormal_embryogenesis/_devel0.91125097
112MP0005451_abnormal_body_composition0.90421707
113MP0005595_abnormal_vascular_smooth0.90124792
114MP0002254_reproductive_system_inflammat0.89832460
115MP0002282_abnormal_trachea_morphology0.89542113
116MP0002019_abnormal_tumor_incidence0.89503545
117MP0009384_cardiac_valve_regurgitation0.89446777
118MP0003806_abnormal_nucleotide_metabolis0.89102255
119MP0001851_eye_inflammation0.88629340
120MP0010678_abnormal_skin_adnexa0.88524056
121MP0001800_abnormal_humoral_immune0.87639557
122MP0001879_abnormal_lymphatic_vessel0.87134999
123MP0005390_skeleton_phenotype0.86384966
124MP0010030_abnormal_orbit_morphology0.86186058
125MP0009053_abnormal_anal_canal0.85577917
126MP0000716_abnormal_immune_system0.85351709
127MP0002080_prenatal_lethality0.84785989
128MP0005671_abnormal_response_to0.84623034
129MP0000767_abnormal_smooth_muscle0.84078553
130MP0002998_abnormal_bone_remodeling0.82736324
131MP0005464_abnormal_platelet_physiology0.82506451
132MP0002722_abnormal_immune_system0.82439180
133MP0003795_abnormal_bone_structure0.82028109
134MP0002925_abnormal_cardiovascular_devel0.81398307
135MP0000604_amyloidosis0.81213508
136MP0010771_integument_phenotype0.80620954
137MP0004883_abnormal_blood_vessel0.78250307
138MP0001191_abnormal_skin_condition0.74358941
139MP0004510_myositis0.74111125
140MP0000013_abnormal_adipose_tissue0.73042308
141MP0002168_other_aberrant_phenotype0.71710239
142MP0004233_abnormal_muscle_weight0.70844607
143MP0003045_fibrosis0.69332546
144MP0005384_cellular_phenotype0.67731330
145MP0009931_abnormal_skin_appearance0.67566917
146MP0000003_abnormal_adipose_tissue0.67290498
147MP0000249_abnormal_blood_vessel0.66781591
148MP0001614_abnormal_blood_vessel0.65652706
149MP0000681_abnormal_thyroid_gland0.65444168

Predicted human phenotypes

RankGene SetZ-score
1Vascular tortuosity (HP:0004948)3.66609381
2Arterial tortuosity (HP:0005116)3.59238348
3Abnormality of liposaccharide metabolism (HP:0010968)3.33423145
4Abnormality of glycosphingolipid metabolism (HP:0004343)3.33423145
5Abnormality of glycolipid metabolism (HP:0010969)3.33423145
6Protrusio acetabuli (HP:0003179)3.29723644
7Follicular hyperkeratosis (HP:0007502)3.20987955
8Eczematoid dermatitis (HP:0000976)2.99240734
9Hematochezia (HP:0002573)2.97328350
10Cervical subluxation (HP:0003308)2.97184538
11Fragile skin (HP:0001030)2.97077081
12Recurrent abscess formation (HP:0002722)2.96023247
13Thrombocytosis (HP:0001894)2.95447455
14Ankle contracture (HP:0006466)2.93325303
15Bladder diverticulum (HP:0000015)2.90009709
16Abnormality of cells of the erythroid lineage (HP:0012130)2.88261417
17Premature rupture of membranes (HP:0001788)2.87936381
18Cerebral aneurysm (HP:0004944)2.80573267
19Osteolytic defects of the hand bones (HP:0009699)2.77671207
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.77671207
21Selective tooth agenesis (HP:0001592)2.76259277
22Dysostosis multiplex (HP:0000943)2.74562776
23Abnormal number of erythroid precursors (HP:0012131)2.58950238
24Reticulocytopenia (HP:0001896)2.57673285
25Elbow flexion contracture (HP:0002987)2.55627974
26Urinary glycosaminoglycan excretion (HP:0003541)2.51692142
27Mucopolysacchariduria (HP:0008155)2.51692142
28Recurrent bacterial skin infections (HP:0005406)2.50589764
29Shallow orbits (HP:0000586)2.48033154
30Elevated erythrocyte sedimentation rate (HP:0003565)2.43494772
31Spinal rigidity (HP:0003306)2.38237473
32Abnormality of polysaccharide metabolism (HP:0011012)2.37400539
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37400539
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37400539
35Radial bowing (HP:0002986)2.34698274
36Abnormality of macrophages (HP:0004311)2.33871166
37Aortic regurgitation (HP:0001659)2.33432517
38Asymmetry of the thorax (HP:0001555)2.29426111
39Tetraparesis (HP:0002273)2.29295139
40Nonimmune hydrops fetalis (HP:0001790)2.24981095
41Short nail (HP:0001799)2.24605754
42Colon cancer (HP:0003003)2.23321913
43Onycholysis (HP:0001806)2.22700673
44Subacute progressive viral hepatitis (HP:0006572)2.22522789
45Peritonitis (HP:0002586)2.22482445
46Aortic dissection (HP:0002647)2.22148451
47Abnormality of dentin (HP:0010299)2.19161237
48Interstitial pulmonary disease (HP:0006530)2.18715936
49Entropion (HP:0000621)2.18704111
50Natal tooth (HP:0000695)2.18499772
51Atrophic scars (HP:0001075)2.18192511
52Orthostatic hypotension (HP:0001278)2.15375709
53Broad face (HP:0000283)2.15099600
54Rectal prolapse (HP:0002035)2.13976033
55Aneurysm (HP:0002617)2.13588972
56Myocardial infarction (HP:0001658)2.13119692
57Broad metatarsal (HP:0001783)2.12168812
58Aortic aneurysm (HP:0004942)2.10929243
59Increased density of long bones (HP:0006392)2.06581896
60Abnormal delivery (HP:0001787)2.06233068
61Genu recurvatum (HP:0002816)2.05944327
62Persistence of primary teeth (HP:0006335)2.05775264
63Deviation of the thumb (HP:0009603)2.04272460
64Thick nail (HP:0001805)2.03969808
65Vertebral compression fractures (HP:0002953)2.03208538
66Cellulitis (HP:0100658)2.02388030
67Ulnar bowing (HP:0003031)2.02362005
68Myositis (HP:0100614)2.01815102
69Dilatation of the ascending aorta (HP:0005111)1.99259984
70Abnormality of the peritoneum (HP:0002585)1.99164334
71Mitral valve prolapse (HP:0001634)1.98773502
72Chronic otitis media (HP:0000389)1.98308363
73Alopecia of scalp (HP:0002293)1.97967274
74High pitched voice (HP:0001620)1.96965697
75Increased cerebral lipofuscin (HP:0011813)1.96455194
76Thoracolumbar scoliosis (HP:0002944)1.96269101
77Spinal cord lesions (HP:0100561)1.95617519
78Syringomyelia (HP:0003396)1.95617519
79Hepatosplenomegaly (HP:0001433)1.94598960
80Mediastinal lymphadenopathy (HP:0100721)1.94464830
81Mitral stenosis (HP:0001718)1.92939215
82Absent frontal sinuses (HP:0002688)1.91439178
83Abnormality of the acetabulum (HP:0003170)1.91163351
84Short 4th metacarpal (HP:0010044)1.89550654
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89550654
86Vacuolated lymphocytes (HP:0001922)1.89540832
87Proximal placement of thumb (HP:0009623)1.88139901
88Spondylolisthesis (HP:0003302)1.87650688
89Cardiovascular calcification (HP:0011915)1.86957483
90Right ventricular cardiomyopathy (HP:0011663)1.85963215
91Poor head control (HP:0002421)1.85089833
92Hyperextensible skin (HP:0000974)1.84239950
93Polycythemia (HP:0001901)1.84151735
94Abnormality of skull ossification (HP:0002703)1.83911832
95Delayed cranial suture closure (HP:0000270)1.83280594
96Micronodular cirrhosis (HP:0001413)1.82863917
97Ankyloglossia (HP:0010296)1.81473374
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.80999366
99Wormian bones (HP:0002645)1.80957635
100Short middle phalanx of the 5th finger (HP:0004220)1.80913507
101Thin bony cortex (HP:0002753)1.79756084
102Missing ribs (HP:0000921)1.79004910
103Chest pain (HP:0100749)1.78762898
104Achilles tendon contracture (HP:0001771)1.78648757
105Bicuspid aortic valve (HP:0001647)1.78472896
106Pallor (HP:0000980)1.77950352
107* Joint laxity (HP:0001388)1.77790773
108Abnormal platelet function (HP:0011869)1.77566946
109Impaired platelet aggregation (HP:0003540)1.77566946
110Bowed forearm bones (HP:0003956)1.76490255
111Bowing of the arm (HP:0006488)1.76490255
112Delayed closure of the anterior fontanelle (HP:0001476)1.75425777
113Spontaneous hematomas (HP:0007420)1.74472203
114Slender long bone (HP:0003100)1.73108246
115Joint stiffness (HP:0001387)1.73091323
116Blue sclerae (HP:0000592)1.72857517
117Abnormality of the calcaneus (HP:0008364)1.72817314
118Disinhibition (HP:0000734)1.72590477
119Agnosia (HP:0010524)1.72264400
120Knee flexion contracture (HP:0006380)1.71296989
121Scanning speech (HP:0002168)1.71296491
122Exostoses (HP:0100777)1.70882258
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.68327563
124Abnormality of the vasculature of the conjunctiva (HP:0008054)1.68271683
125Abnormality of oral frenula (HP:0000190)1.68134141
126Amaurosis fugax (HP:0100576)1.67942082
127Venous abnormality (HP:0002624)1.67210796
128Overgrowth (HP:0001548)1.66448509
129Abnormality of the distal phalanges of the toes (HP:0010182)1.66446290
130Abnormality of the lumbar spine (HP:0100712)1.66357455
131Reduced subcutaneous adipose tissue (HP:0003758)1.66181992
132Biconcave vertebral bodies (HP:0004586)1.66084682
133Soft skin (HP:0000977)1.65842732
134Autoimmune thrombocytopenia (HP:0001973)1.65324590
135Osteopenia (HP:0000938)1.63108862
136Chronic obstructive pulmonary disease (HP:0006510)1.62459716
137Obstructive lung disease (HP:0006536)1.62459716
138Long toe (HP:0010511)1.62416743
139Hallux valgus (HP:0001822)1.61606546
140Deviation of the hallux (HP:0010051)1.61585836
141Amyloidosis (HP:0011034)1.59745998
142Ovoid vertebral bodies (HP:0003300)1.59708566
143Distal lower limb muscle weakness (HP:0009053)1.59389835
144Trismus (HP:0000211)1.59233390
145Decreased skull ossification (HP:0004331)1.59160403
146Protruding ear (HP:0000411)1.58938086
147Sparse lateral eyebrow (HP:0005338)1.58892629
148Platyspondyly (HP:0000926)1.58705227
149Glossoptosis (HP:0000162)1.58069688
150Mitral regurgitation (HP:0001653)1.57840163
151Multiple enchondromatosis (HP:0005701)1.57801682
152Abnormality of the nasal mucosa (HP:0000433)1.57433514
153Cutaneous melanoma (HP:0012056)1.57335802
15411 pairs of ribs (HP:0000878)1.55955403
155Atresia of the external auditory canal (HP:0000413)1.54657641
156Recurrent viral infections (HP:0004429)1.53625098
157Coxa valga (HP:0002673)1.53170001
158Abnormality of the thoracic spine (HP:0100711)1.52647104
159Skin ulcer (HP:0200042)1.52307809
160Severe short stature (HP:0003510)1.52193972
161Petechiae (HP:0000967)1.52094654
162Periodontitis (HP:0000704)1.51420604
163Abnormality of the pericardium (HP:0001697)1.50829530
164Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.50386583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.60305059
2IRAK32.77887798
3TRIB32.75867330
4NME22.58042347
5SCYL22.56775433
6EEF2K2.49959748
7LRRK22.48951885
8MYLK2.42470904
9STK102.41845817
10AKT32.35545337
11ERN12.26739310
12TGFBR21.90427560
13FLT31.87568023
14MST41.86501062
15MST1R1.85274038
16CDC71.78517957
17PAK41.75746945
18PTK61.74223572
19RPS6KA41.72324863
20MAP3K131.72291536
21TTN1.70534702
22TESK11.70239899
23RPS6KB21.61047478
24WEE11.55414868
25MAP3K61.54587219
26CDK121.54548333
27TGFBR11.53378836
28PASK1.47237646
29MAP3K81.41944592
30MAP3K101.41374792
31BLK1.40054872
32NEK21.33948087
33DDR21.29490256
34LATS21.27345144
35JAK31.27211718
36ZAP701.26068271
37PDGFRA1.25740782
38SMG11.21791356
39PBK1.20619866
40LMTK21.19478504
41EIF2AK31.16734625
42CDK61.16395706
43MAP4K11.12964903
44CLK11.11600403
45STK31.11167379
46KDR1.10935300
47BTK1.10710312
48ERBB41.09196090
49RIPK11.08825923
50EPHA21.07675010
51TBK11.07641890
52DYRK31.06594613
53EIF2AK11.05137454
54NTRK11.04301573
55TESK21.02228514
56PIM21.01960552
57TYK21.00878778
58PIM11.00834444
59MAP3K110.98841265
60TAOK20.98663233
61MET0.98448586
62MKNK10.98376133
63CDK70.98209421
64BMX0.98006490
65MATK0.97560656
66FER0.97219697
67BMPR20.96616393
68TEC0.95440332
69DMPK0.95172524
70LATS10.93398457
71PAK20.93390432
72MAP2K30.93298549
73ARAF0.92112803
74TRPM70.91576974
75NEK90.91293848
76CDK40.88015839
77ALK0.86548779
78ACVR1B0.86066831
79NEK10.84525378
80RAF10.83391959
81STK40.82487820
82PDGFRB0.80900624
83CAMK1D0.78244071
84MAP3K10.77849993
85LIMK10.77792397
86FGFR10.76501202
87AURKB0.75775420
88KIT0.75336455
89ILK0.74160284
90PIK3CG0.73703651
91BRSK20.73530468
92MAP3K30.73427597
93ITK0.72560686
94IKBKB0.72476518
95IRAK40.71181073
96STK380.70695615
97PRPF4B0.67079788
98MAPKAPK30.65656616
99ATR0.64694507
100KSR20.63872914
101MAP3K140.62176597
102MAP2K20.61747959
103PTK20.61191822
104JAK20.57866595
105STK38L0.57866544
106EPHB10.57357054
107RIPK40.57076227
108TAOK30.56568859
109PRKD20.55308248
110PRKG20.55241117
111MELK0.53656638
112CSF1R0.53174841
113MTOR0.52558969
114MAP3K20.52242662
115TIE10.50884651
116EGFR0.50468568
117CSK0.49982417
118ABL20.48813471
119MARK30.47669487
120PAK10.46183888
121HCK0.46116852
122CDC42BPA0.45885414
123RET0.45666477
124PLK40.45140229
125STK240.44606231
126LCK0.44463177
127MOS0.44141562
128MAP3K120.43515565
129NLK0.43435456
130MAPKAPK20.43270894
131GSK3A0.43071299
132MAPK110.42454006
133CHUK0.42228590
134SIK10.41468004
135FGFR40.40270858
136JAK10.38825620
137ABL10.38407429
138BCKDK0.37215598
139CHEK10.37158263
140EPHA30.36846961
141PTK2B0.36743280

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.63378523
2Ribosome_Homo sapiens_hsa030102.38711316
3Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.16994418
4Leishmaniasis_Homo sapiens_hsa051401.93902680
5Legionellosis_Homo sapiens_hsa051341.69826980
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68860397
7Mismatch repair_Homo sapiens_hsa034301.65050756
8Spliceosome_Homo sapiens_hsa030401.60874134
9Antigen processing and presentation_Homo sapiens_hsa046121.59744960
10Small cell lung cancer_Homo sapiens_hsa052221.58551320
11Protein export_Homo sapiens_hsa030601.47942704
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46773645
13Cell cycle_Homo sapiens_hsa041101.43656745
14Chronic myeloid leukemia_Homo sapiens_hsa052201.38155661
15Base excision repair_Homo sapiens_hsa034101.37119341
16RNA transport_Homo sapiens_hsa030131.36897348
17Toxoplasmosis_Homo sapiens_hsa051451.35327514
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34763659
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.33070446
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.30674194
21Viral carcinogenesis_Homo sapiens_hsa052031.29840775
22Sphingolipid metabolism_Homo sapiens_hsa006001.29577788
23Herpes simplex infection_Homo sapiens_hsa051681.29484651
24Shigellosis_Homo sapiens_hsa051311.28022084
25One carbon pool by folate_Homo sapiens_hsa006701.27821719
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26792988
27p53 signaling pathway_Homo sapiens_hsa041151.26725460
28Osteoclast differentiation_Homo sapiens_hsa043801.26274307
29Systemic lupus erythematosus_Homo sapiens_hsa053221.26231764
30ECM-receptor interaction_Homo sapiens_hsa045121.26030243
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25635549
32Malaria_Homo sapiens_hsa051441.24948452
33N-Glycan biosynthesis_Homo sapiens_hsa005101.24556279
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23740913
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19571421
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19181583
37Measles_Homo sapiens_hsa051621.18537389
38Proteoglycans in cancer_Homo sapiens_hsa052051.16159938
39Hepatitis B_Homo sapiens_hsa051611.15576372
40Protein digestion and absorption_Homo sapiens_hsa049741.15560312
41Apoptosis_Homo sapiens_hsa042101.15474893
42Hepatitis C_Homo sapiens_hsa051601.14339482
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14121190
44Nucleotide excision repair_Homo sapiens_hsa034201.13972014
45Focal adhesion_Homo sapiens_hsa045101.13145531
46MicroRNAs in cancer_Homo sapiens_hsa052061.12313697
47Pertussis_Homo sapiens_hsa051331.11976265
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10833489
49HTLV-I infection_Homo sapiens_hsa051661.09170453
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08988521
51TNF signaling pathway_Homo sapiens_hsa046681.08810993
52Amoebiasis_Homo sapiens_hsa051461.08106137
53Viral myocarditis_Homo sapiens_hsa054161.05610823
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05031755
55Salmonella infection_Homo sapiens_hsa051321.04482006
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04465399
57Tuberculosis_Homo sapiens_hsa051521.03660373
58Thyroid cancer_Homo sapiens_hsa052161.01294266
59Sulfur metabolism_Homo sapiens_hsa009201.00539061
60Homologous recombination_Homo sapiens_hsa034401.00385956
61Lysosome_Homo sapiens_hsa041420.99957987
62Renin-angiotensin system_Homo sapiens_hsa046140.99031708
63Adherens junction_Homo sapiens_hsa045200.98812252
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97209289
65Fructose and mannose metabolism_Homo sapiens_hsa000510.95207199
66Glutathione metabolism_Homo sapiens_hsa004800.93091794
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92361290
68B cell receptor signaling pathway_Homo sapiens_hsa046620.92027929
69Proteasome_Homo sapiens_hsa030500.91672846
70Bladder cancer_Homo sapiens_hsa052190.91049277
71Hematopoietic cell lineage_Homo sapiens_hsa046400.90113909
72TGF-beta signaling pathway_Homo sapiens_hsa043500.89935174
73Pancreatic cancer_Homo sapiens_hsa052120.89496127
74Influenza A_Homo sapiens_hsa051640.89394765
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.88126947
76Acute myeloid leukemia_Homo sapiens_hsa052210.87845157
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.87098583
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85957454
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85436560
80Colorectal cancer_Homo sapiens_hsa052100.84598832
81Asthma_Homo sapiens_hsa053100.83033595
82Epstein-Barr virus infection_Homo sapiens_hsa051690.82854760
83Rheumatoid arthritis_Homo sapiens_hsa053230.82564440
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.81792266
85Platelet activation_Homo sapiens_hsa046110.80394108
86Allograft rejection_Homo sapiens_hsa053300.78377265
87Phagosome_Homo sapiens_hsa041450.77950296
88Prostate cancer_Homo sapiens_hsa052150.77929898
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77446248
90Mineral absorption_Homo sapiens_hsa049780.74941538
91Caffeine metabolism_Homo sapiens_hsa002320.74589188
92Non-homologous end-joining_Homo sapiens_hsa034500.73860417
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73105834
94Fatty acid biosynthesis_Homo sapiens_hsa000610.72867339
95Hippo signaling pathway_Homo sapiens_hsa043900.71932163
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71505049
97Graft-versus-host disease_Homo sapiens_hsa053320.71340092
98RNA degradation_Homo sapiens_hsa030180.70330755
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.70304495
100Vibrio cholerae infection_Homo sapiens_hsa051100.70126409
101Pathways in cancer_Homo sapiens_hsa052000.68339023
102Endocytosis_Homo sapiens_hsa041440.68229069
103HIF-1 signaling pathway_Homo sapiens_hsa040660.67896551
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67392059
105mRNA surveillance pathway_Homo sapiens_hsa030150.66138206
106Renal cell carcinoma_Homo sapiens_hsa052110.65799162
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.64183418
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.64006938
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63700715
110Galactose metabolism_Homo sapiens_hsa000520.62710636
111Melanoma_Homo sapiens_hsa052180.62236467
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61644585
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61159103
114Pyrimidine metabolism_Homo sapiens_hsa002400.60924755
115Notch signaling pathway_Homo sapiens_hsa043300.60114507
116Other glycan degradation_Homo sapiens_hsa005110.60112010
117Pentose phosphate pathway_Homo sapiens_hsa000300.58644867
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58577901
119Non-small cell lung cancer_Homo sapiens_hsa052230.58429302
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58046565
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57328409
122Prion diseases_Homo sapiens_hsa050200.56075252
123Folate biosynthesis_Homo sapiens_hsa007900.55716250
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51923749
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51669920
126Complement and coagulation cascades_Homo sapiens_hsa046100.51176499
127African trypanosomiasis_Homo sapiens_hsa051430.48074232
128Vitamin B6 metabolism_Homo sapiens_hsa007500.43766344
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41553657
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.40545918
131Staphylococcus aureus infection_Homo sapiens_hsa051500.39684170

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