TMEM167A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.96020159
2ribosome assembly (GO:0042255)4.49421265
3chromatin remodeling at centromere (GO:0031055)4.38413830
4CENP-A containing nucleosome assembly (GO:0034080)4.37582484
5DNA double-strand break processing (GO:0000729)4.23956906
6nuclear pore organization (GO:0006999)4.03972778
7nuclear pore complex assembly (GO:0051292)4.03121458
8mitotic metaphase plate congression (GO:0007080)3.90716398
9histone exchange (GO:0043486)3.86700623
10regulation of mitotic spindle checkpoint (GO:1903504)3.79270845
11regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.79270845
12DNA damage response, detection of DNA damage (GO:0042769)3.79116052
13proteasome assembly (GO:0043248)3.77117780
14protein neddylation (GO:0045116)3.71445855
15regulation of helicase activity (GO:0051095)3.65917696
16DNA replication checkpoint (GO:0000076)3.64290926
17negative regulation of DNA-dependent DNA replication (GO:2000104)3.63419941
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62434534
19establishment of viral latency (GO:0019043)3.61054592
20DNA replication-independent nucleosome organization (GO:0034724)3.59858502
21DNA replication-independent nucleosome assembly (GO:0006336)3.59858502
22spindle checkpoint (GO:0031577)3.53708614
23negative regulation of mitotic sister chromatid separation (GO:2000816)3.53383856
24negative regulation of sister chromatid segregation (GO:0033046)3.53383856
25negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.53383856
26negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.53383856
27negative regulation of mitotic sister chromatid segregation (GO:0033048)3.53383856
28cullin deneddylation (GO:0010388)3.52997239
29mitotic spindle checkpoint (GO:0071174)3.52576730
30metaphase plate congression (GO:0051310)3.51352492
31IMP biosynthetic process (GO:0006188)3.50591841
32regulation of centriole replication (GO:0046599)3.49831955
33protein localization to kinetochore (GO:0034501)3.48091475
34negative regulation of chromosome segregation (GO:0051985)3.44869978
35non-recombinational repair (GO:0000726)3.41970980
36double-strand break repair via nonhomologous end joining (GO:0006303)3.41970980
37negative regulation of DNA recombination (GO:0045910)3.37587113
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30915207
39regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28881901
40regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28881901
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28863922
42histone mRNA metabolic process (GO:0008334)3.24600040
43pre-miRNA processing (GO:0031054)3.24147603
44IMP metabolic process (GO:0046040)3.22896045
45protein deneddylation (GO:0000338)3.20531545
46mitotic spindle assembly checkpoint (GO:0007094)3.20378591
47purine nucleobase biosynthetic process (GO:0009113)3.19522476
48regulation of mitotic sister chromatid separation (GO:0010965)3.18838544
49regulation of mitotic sister chromatid segregation (GO:0033047)3.18838544
50regulation of sister chromatid segregation (GO:0033045)3.18838544
51spindle assembly checkpoint (GO:0071173)3.15513968
52DNA ligation (GO:0006266)3.12630030
53regulation of chromosome segregation (GO:0051983)3.10033861
54paraxial mesoderm development (GO:0048339)3.07005506
55chaperone-mediated protein transport (GO:0072321)3.05403004
56telomere maintenance via telomerase (GO:0007004)3.03367058
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01278001
58negative regulation of ligase activity (GO:0051352)3.01278001
59RNA-dependent DNA replication (GO:0006278)3.00590351
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99857947
61DNA replication-dependent nucleosome assembly (GO:0006335)2.99389322
62DNA replication-dependent nucleosome organization (GO:0034723)2.99389322
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97429893
64mitotic G2/M transition checkpoint (GO:0044818)2.96131388
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94575616
66establishment of chromosome localization (GO:0051303)2.91952106
67DNA catabolic process, exonucleolytic (GO:0000738)2.91324880
68nucleobase biosynthetic process (GO:0046112)2.90708726
69presynaptic membrane assembly (GO:0097105)2.90102852
70establishment of protein localization to mitochondrial membrane (GO:0090151)2.85912778
71protein complex localization (GO:0031503)2.85480665
72pore complex assembly (GO:0046931)2.85129710
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84576763
74response to X-ray (GO:0010165)2.82217465
75anterior/posterior axis specification, embryo (GO:0008595)2.82068763
76maturation of 5.8S rRNA (GO:0000460)2.80522161
77negative regulation of mitosis (GO:0045839)2.78762453
78positive regulation of SMAD protein import into nucleus (GO:0060391)2.76318216
79mitotic nuclear envelope disassembly (GO:0007077)2.74845169
80L-serine metabolic process (GO:0006563)2.70779618
81regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.66840067
82respiratory chain complex IV assembly (GO:0008535)2.65912451
83somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64316641
84somatic hypermutation of immunoglobulin genes (GO:0016446)2.64316641
85DNA strand elongation involved in DNA replication (GO:0006271)2.63411705
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.62756053
87regulation of coenzyme metabolic process (GO:0051196)2.62692511
88regulation of cofactor metabolic process (GO:0051193)2.62692511
89female gonad development (GO:0008585)2.62495620
90protein localization to chromosome, centromeric region (GO:0071459)2.62348756
91lactate metabolic process (GO:0006089)2.61884397
92regulation of ubiquitin-protein transferase activity (GO:0051438)2.61404115
93negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.61347517
94cellular protein complex localization (GO:0034629)2.61218676
95nuclear envelope disassembly (GO:0051081)2.60525104
96membrane disassembly (GO:0030397)2.60525104
97ATP-dependent chromatin remodeling (GO:0043044)2.60076792
98tRNA aminoacylation for protein translation (GO:0006418)2.60023308
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59960192
100ventricular cardiac muscle cell development (GO:0055015)2.59458526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.28457815
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79432142
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.20191161
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09592634
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.85231990
6ELK1_19687146_ChIP-ChIP_HELA_Human2.63203687
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.61049915
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47979955
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44303118
10FUS_26573619_Chip-Seq_HEK293_Human2.29835728
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.28841338
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21051254
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20270574
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19913490
15AR_21909140_ChIP-Seq_LNCAP_Human2.19045609
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16410025
17EWS_26573619_Chip-Seq_HEK293_Human2.15088478
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.01672099
19TAF15_26573619_Chip-Seq_HEK293_Human1.99081931
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90179202
21* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85717688
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85572780
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85039388
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83905018
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82727937
26VDR_22108803_ChIP-Seq_LS180_Human1.76477852
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.75379220
28P300_19829295_ChIP-Seq_ESCs_Human1.73428968
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67832248
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67791141
31NANOG_16153702_ChIP-ChIP_HESCs_Human1.66683230
32IGF1R_20145208_ChIP-Seq_DFB_Human1.64027894
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60392190
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58723784
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58581633
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57264842
37GBX2_23144817_ChIP-Seq_PC3_Human1.55739572
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55111152
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52753388
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52494334
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.47793877
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45838063
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44780935
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42504293
45VDR_23849224_ChIP-Seq_CD4+_Human1.42112325
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40607133
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.38506659
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38289856
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38179409
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36193164
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35638942
52ZNF274_21170338_ChIP-Seq_K562_Hela1.34954857
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34676662
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34430672
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33488587
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32263491
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29865166
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29686586
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.29110073
60* FOXP3_21729870_ChIP-Seq_TREG_Human1.25133705
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23272005
62MYC_18940864_ChIP-ChIP_HL60_Human1.20009489
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.18592624
64DCP1A_22483619_ChIP-Seq_HELA_Human1.18478831
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17973840
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16218509
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14286007
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13361122
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12656386
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11914885
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10830652
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10558468
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08404365
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08404365
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08404365
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08175173
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07944092
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.07540887
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06379348
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.06301546
81TTF2_22483619_ChIP-Seq_HELA_Human1.05774347
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05438971
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04736925
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04474469
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03344912
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02270652
87SOX17_20123909_ChIP-Seq_XEN_Mouse1.02153013
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01630984
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99296890
90SMAD3_21741376_ChIP-Seq_EPCs_Human0.98896845
91SMAD4_21799915_ChIP-Seq_A2780_Human0.98733209
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98361520
93ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98274167
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98009479
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97601314
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95251800
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95130366
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.94512549
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92337944
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.92198571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.27533061
2MP0004957_abnormal_blastocyst_morpholog3.29322296
3MP0003890_abnormal_embryonic-extraembry2.90998800
4MP0010094_abnormal_chromosome_stability2.90202445
5MP0008057_abnormal_DNA_replication2.87905154
6MP0008058_abnormal_DNA_repair2.84350898
7MP0003693_abnormal_embryo_hatching2.56189874
8MP0008932_abnormal_embryonic_tissue2.46561034
9MP0002102_abnormal_ear_morphology2.44531592
10MP0003111_abnormal_nucleus_morphology2.42521154
11MP0002254_reproductive_system_inflammat2.39297364
12MP0003077_abnormal_cell_cycle2.17679627
13MP0003718_maternal_effect2.16151318
14MP0009697_abnormal_copulation2.12962644
15MP0001188_hyperpigmentation2.10672330
16MP0008007_abnormal_cellular_replicative2.04851592
17MP0001529_abnormal_vocalization1.98049460
18MP0010352_gastrointestinal_tract_polyps1.94525390
19MP0001293_anophthalmia1.93719016
20MP0008877_abnormal_DNA_methylation1.90791301
21MP0003567_abnormal_fetal_cardiomyocyte1.84661352
22MP0009672_abnormal_birth_weight1.82913652
23MP0003119_abnormal_digestive_system1.76546149
24MP0003937_abnormal_limbs/digits/tail_de1.76134851
25MP0001177_atelectasis1.75374832
26MP0001730_embryonic_growth_arrest1.71597365
27MP0006054_spinal_hemorrhage1.67613019
28MP0006072_abnormal_retinal_apoptosis1.50849078
29MP0003121_genomic_imprinting1.50801025
30MP0003123_paternal_imprinting1.48019226
31MP0002084_abnormal_developmental_patter1.46329731
32MP0001672_abnormal_embryogenesis/_devel1.41701704
33MP0005380_embryogenesis_phenotype1.41701704
34MP0001984_abnormal_olfaction1.41435094
35MP0002233_abnormal_nose_morphology1.40266003
36MP0009703_decreased_birth_body1.39921042
37MP0001697_abnormal_embryo_size1.38681213
38MP0002085_abnormal_embryonic_tissue1.38461443
39MP0006035_abnormal_mitochondrial_morpho1.37591488
40MP0002697_abnormal_eye_size1.35333774
41MP0003122_maternal_imprinting1.34906728
42MP0002938_white_spotting1.34287107
43MP0002751_abnormal_autonomic_nervous1.33646191
44MP0001286_abnormal_eye_development1.33427859
45MP0005248_abnormal_Harderian_gland1.28259500
46MP0005367_renal/urinary_system_phenotyp1.27968883
47MP0000516_abnormal_urinary_system1.27968883
48MP0002090_abnormal_vision1.27064975
49MP0010386_abnormal_urinary_bladder1.24317761
50MP0000350_abnormal_cell_proliferation1.22953482
51MP0001299_abnormal_eye_distance/1.21056964
52MP0003984_embryonic_growth_retardation1.19009002
53MP0003195_calcinosis1.18881377
54MP0004270_analgesia1.18408565
55MP0002088_abnormal_embryonic_growth/wei1.18248121
56MP0004197_abnormal_fetal_growth/weight/1.14864831
57MP0000647_abnormal_sebaceous_gland1.12647458
58MP0003221_abnormal_cardiomyocyte_apopto1.11263710
59MP0002736_abnormal_nociception_after1.09107017
60MP0004133_heterotaxia1.08616795
61MP0002111_abnormal_tail_morphology1.04957216
62MP0010234_abnormal_vibrissa_follicle1.02423109
63MP0002080_prenatal_lethality1.01609025
64MP0004215_abnormal_myocardial_fiber0.99338349
65MP0010307_abnormal_tumor_latency0.99335564
66MP0000537_abnormal_urethra_morphology0.98356925
67MP0003880_abnormal_central_pattern0.97645961
68MP0005253_abnormal_eye_physiology0.94383987
69MP0004272_abnormal_basement_membrane0.92595608
70MP0002086_abnormal_extraembryonic_tissu0.90805571
71MP0000358_abnormal_cell_content/0.90791006
72MP0003787_abnormal_imprinting0.89613686
73MP0003861_abnormal_nervous_system0.88114731
74MP0000428_abnormal_craniofacial_morphol0.86271471
75MP0003755_abnormal_palate_morphology0.85840222
76MP0008789_abnormal_olfactory_epithelium0.84490544
77MP0003786_premature_aging0.81912472
78MP0003186_abnormal_redox_activity0.81478313
79MP0006292_abnormal_olfactory_placode0.81456948
80MP0003136_yellow_coat_color0.81269230
81MP0005187_abnormal_penis_morphology0.80652719
82MP0003385_abnormal_body_wall0.79087490
83MP0005391_vision/eye_phenotype0.78421132
84MP0000372_irregular_coat_pigmentation0.78300215
85MP0001486_abnormal_startle_reflex0.77501429
86MP0003935_abnormal_craniofacial_develop0.75088830
87MP0001915_intracranial_hemorrhage0.74350881
88MP0005395_other_phenotype0.73953581
89MP0005408_hypopigmentation0.73888509
90MP0003806_abnormal_nucleotide_metabolis0.73584023
91MP0000432_abnormal_head_morphology0.73057816
92MP0000579_abnormal_nail_morphology0.72029484
93MP0001324_abnormal_eye_pigmentation0.71936056
94MP0002184_abnormal_innervation0.69858201
95MP0002092_abnormal_eye_morphology0.69501080
96MP0002081_perinatal_lethality0.67024740
97MP0009046_muscle_twitch0.66821400
98MP0000631_abnormal_neuroendocrine_gland0.66632855
99MP0002734_abnormal_mechanical_nocicepti0.66457128
100MP0001485_abnormal_pinna_reflex0.65655156

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.89826462
2Colon cancer (HP:0003003)3.66254003
3Cortical dysplasia (HP:0002539)3.40441756
4Papillary thyroid carcinoma (HP:0002895)3.05854452
5Ependymoma (HP:0002888)3.04191956
6Rhabdomyosarcoma (HP:0002859)3.00860966
7Abnormal lung lobation (HP:0002101)3.00363995
8Abnormality of methionine metabolism (HP:0010901)2.94073596
9Medulloblastoma (HP:0002885)2.86597724
10Nephroblastoma (Wilms tumor) (HP:0002667)2.78360967
11Biliary tract neoplasm (HP:0100574)2.72744452
12Embryonal renal neoplasm (HP:0011794)2.72728060
13Absent eyebrow (HP:0002223)2.67947232
14Agnosia (HP:0010524)2.67789217
15Thyroid carcinoma (HP:0002890)2.65120737
16Methylmalonic acidemia (HP:0002912)2.60119828
17Glioma (HP:0009733)2.59027505
18Hypoglycemic seizures (HP:0002173)2.55207047
19Pancreatic islet-cell hyperplasia (HP:0004510)2.54708106
20Acute necrotizing encephalopathy (HP:0006965)2.49780593
21Increased hepatocellular lipid droplets (HP:0006565)2.49656904
22Abnormality of chromosome stability (HP:0003220)2.48721330
23Abnormality of the astrocytes (HP:0100707)2.42953512
24Astrocytoma (HP:0009592)2.42953512
25Increased serum pyruvate (HP:0003542)2.39801982
26Neoplasm of the small intestine (HP:0100833)2.39395057
27Acute encephalopathy (HP:0006846)2.36378464
28Neoplasm of the adrenal gland (HP:0100631)2.35140390
29Neoplasm of the colon (HP:0100273)2.34839551
30Progressive macrocephaly (HP:0004481)2.34296363
31Abnormality of serum amino acid levels (HP:0003112)2.33771574
32Postnatal microcephaly (HP:0005484)2.32258481
33Intestinal atresia (HP:0011100)2.32160961
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31815580
35Spastic diplegia (HP:0001264)2.27866388
36Meckel diverticulum (HP:0002245)2.25724317
37Stenosis of the external auditory canal (HP:0000402)2.25067242
38Septo-optic dysplasia (HP:0100842)2.24873998
39Hepatoblastoma (HP:0002884)2.23327215
40Hypoglycemic coma (HP:0001325)2.20322023
41Degeneration of anterior horn cells (HP:0002398)2.18160638
42Abnormality of the anterior horn cell (HP:0006802)2.18160638
43Bifid tongue (HP:0010297)2.16205943
44Impaired vibration sensation in the lower limbs (HP:0002166)2.14583616
45Ovarian neoplasm (HP:0100615)2.14107877
46Abnormality of glycolysis (HP:0004366)2.13693334
47Hyperinsulinemic hypoglycemia (HP:0000825)2.13600595
48Megaloblastic anemia (HP:0001889)2.13100754
49Abnormality of the ileum (HP:0001549)2.13072714
50Abnormal hair whorl (HP:0010721)2.12522755
51Birth length less than 3rd percentile (HP:0003561)2.11423666
52Lipid accumulation in hepatocytes (HP:0006561)2.10839567
53Breast carcinoma (HP:0003002)2.10609976
54Uterine neoplasm (HP:0010784)2.09281046
55Hyperglycinemia (HP:0002154)2.02342194
56Myelomeningocele (HP:0002475)2.00944472
57Neoplasm of striated muscle (HP:0009728)1.95693090
58Chromsome breakage (HP:0040012)1.93774766
59Supernumerary spleens (HP:0009799)1.91191913
60Volvulus (HP:0002580)1.90651546
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.90217278
62Abnormal mitochondria in muscle tissue (HP:0008316)1.89549142
63Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89407259
64Facial cleft (HP:0002006)1.88624709
65Neoplasm of the rectum (HP:0100743)1.87595958
66Shoulder girdle muscle weakness (HP:0003547)1.86853947
67Abnormality of endocrine pancreas physiology (HP:0012093)1.85810136
68Abnormality of the pancreatic islet cells (HP:0006476)1.85810136
69Genital tract atresia (HP:0001827)1.84509760
70Increased CSF lactate (HP:0002490)1.83130154
71Abnormality of the hip-girdle musculature (HP:0001445)1.83118209
72Abnormality of the musculature of the pelvis (HP:0001469)1.83118209
73Leukodystrophy (HP:0002415)1.82789526
74Absent hair (HP:0002298)1.80881898
75Neuroendocrine neoplasm (HP:0100634)1.80605451
76Small intestinal stenosis (HP:0012848)1.80343181
77Duodenal stenosis (HP:0100867)1.80343181
78Gonadotropin excess (HP:0000837)1.80126971
79Malignant gastrointestinal tract tumors (HP:0006749)1.80025871
80Gastrointestinal carcinoma (HP:0002672)1.80025871
81Cerebral edema (HP:0002181)1.79612771
82Neoplasm of the thyroid gland (HP:0100031)1.79286092
83Aqueductal stenosis (HP:0002410)1.79083717
84Abnormality of the duodenum (HP:0002246)1.78581011
85Methylmalonic aciduria (HP:0012120)1.78553537
86Vaginal atresia (HP:0000148)1.77197374
87Angiofibromas (HP:0010615)1.76725572
88Adenoma sebaceum (HP:0009720)1.76725572
89Neoplasm of the adrenal cortex (HP:0100641)1.76158385
90Multiple enchondromatosis (HP:0005701)1.75381722
91Progressive inability to walk (HP:0002505)1.75058704
92Homocystinuria (HP:0002156)1.72570779
93Abnormality of homocysteine metabolism (HP:0010919)1.72570779
94Gastrointestinal atresia (HP:0002589)1.71404460
95Symptomatic seizures (HP:0011145)1.71073528
96Renal Fanconi syndrome (HP:0001994)1.70006206
97Type I transferrin isoform profile (HP:0003642)1.69453933
98Mitochondrial inheritance (HP:0001427)1.68802824
99Scrotal hypoplasia (HP:0000046)1.68489850
100Abnormality of vitamin B metabolism (HP:0004340)1.68295165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.43493791
2SRPK13.33406398
3MKNK23.13493866
4TRIM283.04519373
5MKNK12.76576098
6BUB12.76242588
7TTK2.72243040
8EIF2AK32.63334810
9MST42.60500220
10PLK32.51661828
11TNIK2.44579035
12CDC72.25218474
13BCR2.19448067
14WNK32.14536586
15EIF2AK12.13451542
16NEK12.12591656
17PBK1.98365757
18ZAK1.87454632
19MAP3K41.83656341
20STK38L1.81228863
21PLK41.79403171
22ERBB31.67902291
23BRSK21.66678532
24TAF11.52623713
25MAP3K121.51209185
26CASK1.46274764
27WEE11.39009420
28ACVR1B1.35507062
29BMPR1B1.28437381
30MAP2K71.27754013
31NUAK11.26872875
32STK161.25790197
33PLK21.25391507
34PLK11.25277541
35CSNK1G11.24485699
36MAP4K21.21007216
37STK31.20774559
38CSNK1G21.17242255
39LATS11.12579961
40DYRK31.06207052
41ALK1.03784135
42VRK21.02461362
43CSNK1G31.02434046
44VRK11.02258387
45FRK1.00001104
46DYRK20.96839673
47STK240.96612979
48FGFR20.94916070
49CSNK1A1L0.94434746
50NME10.94301729
51FGFR10.93239443
52ERBB40.92039789
53LATS20.91132968
54PNCK0.88111233
55RPS6KA40.86420162
56PASK0.82058377
57PAK40.79090224
58YES10.77772595
59EIF2AK20.76695039
60OXSR10.75807456
61BRD40.68930178
62GRK10.68531747
63MINK10.68039139
64ATM0.66162667
65SIK30.65953219
66PDK20.65290282
67BRSK10.62338589
68NLK0.61239053
69ATR0.60930119
70PRKCE0.56970003
71FLT30.55202474
72CHEK20.54997809
73CDK60.54783678
74CSNK1E0.53623663
75PRKCG0.50092482
76AURKB0.47544547
77CDK30.47087168
78CDK190.46701030
79TGFBR10.45194076
80FER0.41530546
81NEK20.40589319
82PAK30.40462932
83CHEK10.38533022
84EPHA40.38405517
85STK40.36784894
86CSNK2A10.36693050
87CLK10.35040009
88DAPK10.34375358
89STK390.34125030
90CSNK2A20.33958977
91CDK10.33797145
92KSR10.32984230
93PRKDC0.32210582
94MAP3K50.31811592
95CDK180.31634412
96MAP2K40.29141658
97CDK140.28300559
98EGFR0.28299234
99TIE10.28187585
100MARK10.27847099

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.77293553
2Proteasome_Homo sapiens_hsa030503.77261816
3Mismatch repair_Homo sapiens_hsa034303.22861965
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02077972
5Non-homologous end-joining_Homo sapiens_hsa034502.83638895
6RNA transport_Homo sapiens_hsa030132.40675569
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36826757
8Basal transcription factors_Homo sapiens_hsa030222.29304185
9DNA replication_Homo sapiens_hsa030302.25684735
10Steroid biosynthesis_Homo sapiens_hsa001002.06691125
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03394303
12Vitamin B6 metabolism_Homo sapiens_hsa007502.02336508
13Spliceosome_Homo sapiens_hsa030402.00901725
14Propanoate metabolism_Homo sapiens_hsa006401.95064596
15RNA degradation_Homo sapiens_hsa030181.94381696
16RNA polymerase_Homo sapiens_hsa030201.92308436
17Homologous recombination_Homo sapiens_hsa034401.90842887
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89281937
19Cell cycle_Homo sapiens_hsa041101.86465315
20Oxidative phosphorylation_Homo sapiens_hsa001901.83742830
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78459396
22Parkinsons disease_Homo sapiens_hsa050121.68128049
23Nucleotide excision repair_Homo sapiens_hsa034201.65785358
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.65744168
25Fatty acid elongation_Homo sapiens_hsa000621.57377869
26One carbon pool by folate_Homo sapiens_hsa006701.55817588
27Pyruvate metabolism_Homo sapiens_hsa006201.53656949
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52920040
29Fanconi anemia pathway_Homo sapiens_hsa034601.46383823
30mRNA surveillance pathway_Homo sapiens_hsa030151.44737879
31Oocyte meiosis_Homo sapiens_hsa041141.28376395
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27016794
33Selenocompound metabolism_Homo sapiens_hsa004501.26768341
34Base excision repair_Homo sapiens_hsa034101.22130556
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20485623
36Huntingtons disease_Homo sapiens_hsa050161.20249974
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15846167
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11002087
39Alzheimers disease_Homo sapiens_hsa050101.01702062
40Pyrimidine metabolism_Homo sapiens_hsa002401.00149811
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99979995
42Folate biosynthesis_Homo sapiens_hsa007900.97729833
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95069686
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92108711
45Nicotine addiction_Homo sapiens_hsa050330.91065908
46Purine metabolism_Homo sapiens_hsa002300.88871224
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85759114
48Glutathione metabolism_Homo sapiens_hsa004800.85327150
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81367827
50Biosynthesis of amino acids_Homo sapiens_hsa012300.81346388
51TGF-beta signaling pathway_Homo sapiens_hsa043500.80670220
52p53 signaling pathway_Homo sapiens_hsa041150.79903964
53Sulfur metabolism_Homo sapiens_hsa009200.74239380
54Adherens junction_Homo sapiens_hsa045200.74207726
55Carbon metabolism_Homo sapiens_hsa012000.73546244
56Butanoate metabolism_Homo sapiens_hsa006500.73268128
57Wnt signaling pathway_Homo sapiens_hsa043100.72441262
58beta-Alanine metabolism_Homo sapiens_hsa004100.70341742
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70286441
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68732432
61Fatty acid metabolism_Homo sapiens_hsa012120.67057806
62Collecting duct acid secretion_Homo sapiens_hsa049660.66867058
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65621653
64Hippo signaling pathway_Homo sapiens_hsa043900.64517214
65Tight junction_Homo sapiens_hsa045300.59855325
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58487712
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57972399
68Metabolic pathways_Homo sapiens_hsa011000.57279395
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55875318
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52174297
71Thyroid cancer_Homo sapiens_hsa052160.51241279
72Hedgehog signaling pathway_Homo sapiens_hsa043400.50724664
73GABAergic synapse_Homo sapiens_hsa047270.49861141
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47936968
75Fatty acid degradation_Homo sapiens_hsa000710.47068386
76N-Glycan biosynthesis_Homo sapiens_hsa005100.44715793
77Vitamin digestion and absorption_Homo sapiens_hsa049770.42045912
78Taste transduction_Homo sapiens_hsa047420.41106541
79Regulation of autophagy_Homo sapiens_hsa041400.38862026
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38012017
81Ribosome_Homo sapiens_hsa030100.37602622
82Vibrio cholerae infection_Homo sapiens_hsa051100.36474136
83Peroxisome_Homo sapiens_hsa041460.34330744
84Basal cell carcinoma_Homo sapiens_hsa052170.32763938
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32142114
86Arginine and proline metabolism_Homo sapiens_hsa003300.32112462
87Colorectal cancer_Homo sapiens_hsa052100.31255330
88Serotonergic synapse_Homo sapiens_hsa047260.31212750
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31000442
90Cardiac muscle contraction_Homo sapiens_hsa042600.30681304
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29714430
92Long-term depression_Homo sapiens_hsa047300.26890530
93Circadian rhythm_Homo sapiens_hsa047100.26561152
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.23011802
95Gap junction_Homo sapiens_hsa045400.22384040
96Glutamatergic synapse_Homo sapiens_hsa047240.20764067
97Dopaminergic synapse_Homo sapiens_hsa047280.18093251
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17972884
99Retinol metabolism_Homo sapiens_hsa008300.16805960
100Starch and sucrose metabolism_Homo sapiens_hsa005000.14383074

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