TMEM167B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.79020861
2Golgi transport vesicle coating (GO:0048200)6.79020861
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.19727424
4protein retention in ER lumen (GO:0006621)4.65516688
5negative regulation of cell killing (GO:0031342)4.56174691
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.56174691
7positive regulation of gamma-delta T cell activation (GO:0046645)4.42394775
8response to peptidoglycan (GO:0032494)4.06315134
9neutrophil activation involved in immune response (GO:0002283)4.01595159
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.88739932
11regulation of B cell receptor signaling pathway (GO:0050855)3.76421201
12COPII vesicle coating (GO:0048208)3.73746420
13positive regulation of growth hormone secretion (GO:0060124)3.70532760
14cellular extravasation (GO:0045123)3.56163470
15detection of other organism (GO:0098543)3.54099958
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.53401500
17regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.53382293
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.51097111
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.51097111
20modulation by symbiont of host immune response (GO:0052553)3.51097111
21positive regulation by symbiont of host defense response (GO:0052509)3.51097111
22modulation by symbiont of host defense response (GO:0052031)3.51097111
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.51097111
24negative regulation of interleukin-12 production (GO:0032695)3.48368884
25growth hormone receptor signaling pathway (GO:0060396)3.43103065
26detection of molecule of bacterial origin (GO:0032490)3.36939909
27ER overload response (GO:0006983)3.34622603
28vesicle coating (GO:0006901)3.32858787
29positive regulation of nuclease activity (GO:0032075)3.25847625
30macrophage activation involved in immune response (GO:0002281)3.24761263
31detection of bacterium (GO:0016045)3.23271586
32regulation of gamma-delta T cell activation (GO:0046643)3.22884525
33neutrophil activation (GO:0042119)3.22374830
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.19387704
35detection of external biotic stimulus (GO:0098581)3.15809869
36antigen processing and presentation of endogenous antigen (GO:0019883)3.14910293
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.14770373
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.11527702
39regulation of mast cell activation (GO:0033003)3.11213245
40immunoglobulin mediated immune response (GO:0016064)3.10670552
41endoplasmic reticulum unfolded protein response (GO:0030968)3.08187042
42microglial cell activation (GO:0001774)3.03089914
43negative regulation of glycoprotein biosynthetic process (GO:0010561)3.02714820
44granulocyte activation (GO:0036230)3.01857258
45ER-nucleus signaling pathway (GO:0006984)3.01133381
46cellular response to growth hormone stimulus (GO:0071378)3.00311926
47cellular response to unfolded protein (GO:0034620)3.00098865
48regulation of growth hormone secretion (GO:0060123)2.99981120
49ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.99937766
50positive regulation of mast cell activation (GO:0033005)2.99723644
51neutrophil mediated immunity (GO:0002446)2.94694700
52macrophage activation (GO:0042116)2.94310249
53negative regulation of T cell mediated immunity (GO:0002710)2.92563591
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88001626
55regulation of nuclease activity (GO:0032069)2.86144650
56regulation of regulatory T cell differentiation (GO:0045589)2.85051336
57regulation of interferon-beta biosynthetic process (GO:0045357)2.84450432
58B cell receptor signaling pathway (GO:0050853)2.83716220
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83530959
60response to host immune response (GO:0052572)2.83530959
61UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83145253
62peptide hormone processing (GO:0016486)2.81402085
63detection of biotic stimulus (GO:0009595)2.80834232
64cellular response to topologically incorrect protein (GO:0035967)2.80422051
65germinal center formation (GO:0002467)2.80064936
66cellular response to ethanol (GO:0071361)2.79958263
67exocrine pancreas development (GO:0031017)2.79338354
68regulation of gamma-delta T cell differentiation (GO:0045586)2.77779946
69regulation of T-helper 2 cell differentiation (GO:0045628)2.76755274
70response to muramyl dipeptide (GO:0032495)2.76295610
71regulation of mast cell degranulation (GO:0043304)2.75847609
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74564507
73regulation of mast cell activation involved in immune response (GO:0033006)2.74543679
74macroautophagy (GO:0016236)2.73551602
75endocrine pancreas development (GO:0031018)2.71806712
76myeloid cell activation involved in immune response (GO:0002275)2.70820434
77response to endoplasmic reticulum stress (GO:0034976)2.70613075
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.69693648
79response to interleukin-15 (GO:0070672)2.68929726
80sequestering of metal ion (GO:0051238)2.66206655
81interferon-gamma-mediated signaling pathway (GO:0060333)2.64348827
82negative regulation of leukocyte mediated immunity (GO:0002704)2.63263218
83activated T cell proliferation (GO:0050798)2.63086776
84glycoprotein catabolic process (GO:0006516)2.63082407
85insulin-like growth factor receptor signaling pathway (GO:0048009)2.62056693
86toxin metabolic process (GO:0009404)2.61868916
87tolerance induction (GO:0002507)2.61835893
88alpha-linolenic acid metabolic process (GO:0036109)2.61123758
89valine metabolic process (GO:0006573)2.60923034
90negative regulation of interleukin-17 production (GO:0032700)2.60422701
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59904174
92positive regulation of mast cell activation involved in immune response (GO:0033008)2.59263196
93positive regulation of mast cell degranulation (GO:0043306)2.59263196
94regulation of memory T cell differentiation (GO:0043380)2.58106415
95regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56876030
96positive regulation of B cell differentiation (GO:0045579)2.54644870
97negative regulation of glycoprotein metabolic process (GO:1903019)2.54488811
98cellular response to vitamin D (GO:0071305)2.53952922
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53302204
100response to host (GO:0075136)2.53302204
101response to host defenses (GO:0052200)2.53302204
102negative regulation of T-helper cell differentiation (GO:0045623)2.52909897
103negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.52909897
104signal peptide processing (GO:0006465)2.52537962
105regulation of type B pancreatic cell apoptotic process (GO:2000674)2.52332988
106regulation of B cell differentiation (GO:0045577)2.51906049
107negative regulation of erythrocyte differentiation (GO:0045647)2.51714206
108leukocyte aggregation (GO:0070486)2.51596636
109intra-Golgi vesicle-mediated transport (GO:0006891)2.50853748
110negative regulation of type 2 immune response (GO:0002829)2.49814700
111interferon-gamma production (GO:0032609)2.49499725
112cellular response to interleukin-15 (GO:0071350)2.49095884
113production of molecular mediator involved in inflammatory response (GO:0002532)2.48136873
114negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.48104064
115lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47983595
116positive regulation of type 2 immune response (GO:0002830)2.47438628
117positive regulation of cellular amide metabolic process (GO:0034250)2.46242793
118regulation of protein glycosylation (GO:0060049)2.46006789
119regulation of tolerance induction (GO:0002643)2.44174514
120positive regulation of glycogen biosynthetic process (GO:0045725)2.43136124
121myeloid leukocyte mediated immunity (GO:0002444)2.43028696
122insulin secretion (GO:0030073)2.42135593
123positive regulation of insulin secretion (GO:0032024)2.41978603
124negative regulation of interleukin-6 production (GO:0032715)2.40353617
125positive regulation of glycolytic process (GO:0045821)2.40020751
126Golgi organization (GO:0007030)2.39871111
1274-hydroxyproline metabolic process (GO:0019471)2.39664727
128neutrophil chemotaxis (GO:0030593)2.39056733
129regulation of interleukin-17 production (GO:0032660)2.38248499
130regulation of type 2 immune response (GO:0002828)2.38203345
131leukocyte degranulation (GO:0043299)2.37805368
132erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.37688918
133L-phenylalanine catabolic process (GO:0006559)2.37688918
134nerve growth factor signaling pathway (GO:0038180)2.37512157
135leukocyte migration involved in inflammatory response (GO:0002523)2.37456449
136regulation of T cell mediated cytotoxicity (GO:0001914)2.37078123
137dorsal/ventral axis specification (GO:0009950)2.36625902
138positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.36515349
139defense response to protozoan (GO:0042832)2.36022831
140regulation of leukocyte degranulation (GO:0043300)2.36004261
141protein N-linked glycosylation via asparagine (GO:0018279)2.34534817
142intestinal cholesterol absorption (GO:0030299)2.33147800
143regulation of germinal center formation (GO:0002634)2.32970074
144neutrophil migration (GO:1990266)2.32913926
145peptidyl-asparagine modification (GO:0018196)2.32784114
146positive regulation of toll-like receptor signaling pathway (GO:0034123)2.31899208
147regulation of T cell tolerance induction (GO:0002664)2.31865841
148tricarboxylic acid metabolic process (GO:0072350)2.30617903
149negative regulation of immunoglobulin mediated immune response (GO:0002890)2.30012079
150negative regulation of B cell mediated immunity (GO:0002713)2.30012079
151endoplasmic reticulum organization (GO:0007029)2.29579994
152dendritic cell migration (GO:0036336)2.29236346
153regulation of antigen processing and presentation (GO:0002577)2.28775506
154cellular response to vitamin (GO:0071295)2.28503334
155response to unfolded protein (GO:0006986)2.28049836
156ER to Golgi vesicle-mediated transport (GO:0006888)2.25711523
157protein carboxylation (GO:0018214)2.25150351
158peptidyl-glutamic acid carboxylation (GO:0017187)2.25150351
159positive regulation of glucose import (GO:0046326)2.24478604
160protein N-linked glycosylation (GO:0006487)2.20100393
161response to topologically incorrect protein (GO:0035966)2.18482729
162keratan sulfate catabolic process (GO:0042340)2.16728127
163protein maturation by protein folding (GO:0022417)2.14350536
164type B pancreatic cell development (GO:0003323)2.13881940
165L-phenylalanine metabolic process (GO:0006558)2.13818964
166erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.13818964
167regulation of fatty acid beta-oxidation (GO:0031998)2.13753554
168sulfur amino acid catabolic process (GO:0000098)2.12451796
169positive regulation of peptide hormone secretion (GO:0090277)2.12212120
170regulation of glucose import in response to insulin stimulus (GO:2001273)2.12190503
171positive regulation of respiratory burst (GO:0060267)2.11348320
172regulation of glycogen biosynthetic process (GO:0005979)2.07134098
173regulation of glucan biosynthetic process (GO:0010962)2.07134098
174regulation of cholesterol homeostasis (GO:2000188)2.06830421
175homocysteine metabolic process (GO:0050667)2.06672369
176positive regulation of fatty acid beta-oxidation (GO:0032000)2.06550915
177regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.06472004
178regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.06258840
179positive regulation of peptide secretion (GO:0002793)2.04750221
180nitric oxide mediated signal transduction (GO:0007263)2.03806963
181positive regulation of glycogen metabolic process (GO:0070875)2.02440804
182negative regulation of fatty acid transport (GO:2000192)2.01923972
183transcytosis (GO:0045056)2.01688830
184positive regulation of vesicle fusion (GO:0031340)2.01386546
185chondrocyte development (GO:0002063)2.01022051
186phosphatidylinositol phosphorylation (GO:0046854)1.99466391
187regulation of polysaccharide biosynthetic process (GO:0032885)1.98525704
188regulation of insulin secretion (GO:0050796)1.98005339
189protein localization to endosome (GO:0036010)1.97417582
190peptide secretion (GO:0002790)1.96826855
191positive regulation of fatty acid oxidation (GO:0046321)1.96432560
192branched-chain amino acid metabolic process (GO:0009081)1.96054405
193positive regulation of glucose transport (GO:0010828)1.95808832
194regulation of ER to Golgi vesicle-mediated transport (GO:0060628)1.94961776
195hormone catabolic process (GO:0042447)1.94538291
196collagen fibril organization (GO:0030199)1.93925928
197Golgi vesicle transport (GO:0048193)1.93551351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12874444
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.40586558
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.10657256
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08517539
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04422944
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.82717356
7GATA1_22025678_ChIP-Seq_K562_Human2.73817971
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.66945787
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.55023854
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46609213
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45817346
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36469921
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.31783393
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.31240686
15CLOCK_20551151_ChIP-Seq_293T_Human2.28974501
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24410304
17RUNX_20019798_ChIP-Seq_JUKART_Human2.22566660
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11230537
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96814593
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96465414
21VDR_24787735_ChIP-Seq_THP-1_Human1.96154583
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93341577
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88187518
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87618289
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83836522
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.77716592
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.77716592
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71873212
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69954733
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.65215761
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64423798
32SCL_19346495_ChIP-Seq_HPC-7_Human1.62441366
33MYB_26560356_Chip-Seq_TH2_Human1.59944331
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57772076
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57444951
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.57286022
37SPI1_23127762_ChIP-Seq_K562_Human1.49803168
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44354264
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43996863
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43839438
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43391937
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.41710179
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.41641426
44SPI1_23547873_ChIP-Seq_NB4_Human1.40436340
45CJUN_26792858_Chip-Seq_BT549_Human1.38571699
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36745461
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.36452010
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36407481
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35792279
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35284785
51AHR_22903824_ChIP-Seq_MCF-7_Human1.32464641
52AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.31604355
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.30717581
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.29910803
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29520420
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29397314
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28070842
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27427118
59GBX2_23144817_ChIP-Seq_PC3_Human1.27168135
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.27130095
61GATA3_27048872_Chip-Seq_THYMUS_Human1.26680959
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26501308
63GATA3_26560356_Chip-Seq_TH2_Human1.26293524
64RXR_22108803_ChIP-Seq_LS180_Human1.24445890
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24427044
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24255936
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23638838
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23624118
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.23208369
70SOX2_20726797_ChIP-Seq_SW620_Human1.22995507
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21744849
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21635228
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21438792
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20922312
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20740154
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20028512
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.19081770
78* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18711111
79ER_23166858_ChIP-Seq_MCF-7_Human1.18286626
80* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.16785667
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12934754
82IGF1R_20145208_ChIP-Seq_DFB_Human1.12598097
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11966232
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11686348
85* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08919064
86SMRT_27268052_Chip-Seq_Bcells_Human1.08008274
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.07601716
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06801770
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06403445
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06383466
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06080642
92GATA1_19941826_ChIP-Seq_K562_Human1.05940948
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05856734
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05524197
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04600533
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.03922855
97BCAT_22108803_ChIP-Seq_LS180_Human1.03214699
98* MYB_26560356_Chip-Seq_TH1_Human1.03030488
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02885301
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02408368
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01917283
102JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01274275
103SMAD4_21799915_ChIP-Seq_A2780_Human1.01249554
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.00584293
105CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00345643
106PU_27001747_Chip-Seq_BMDM_Mouse0.99904581
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98417061
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97960347
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97510972
110TP63_23658742_ChIP-Seq_EP156T_Human0.97284905
111EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96939345
112RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96939345
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96231656
114* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95784368
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.95643247
116SOX2_21211035_ChIP-Seq_LN229_Gbm0.95573781
117VDR_24763502_ChIP-Seq_THP-1_Human0.95369899
118GATA2_19941826_ChIP-Seq_K562_Human0.93898409
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.93703395
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93284060
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92734886
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92475059
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91861624
124TP53_18474530_ChIP-ChIP_U2OS_Human0.90469265
125TAF15_26573619_Chip-Seq_HEK293_Human0.90247333
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90238501
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.89765149
128AR_21572438_ChIP-Seq_LNCaP_Human0.89621067
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89300061
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88291078
131AR_25329375_ChIP-Seq_VCAP_Human0.88287478
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88239726
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88083717
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87225437
135EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87180864
136DROSHA_22980978_ChIP-Seq_HELA_Human0.86646439
137P300_19829295_ChIP-Seq_ESCs_Human0.86629436
138FLI1_27457419_Chip-Seq_LIVER_Mouse0.86223511
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85412628
140* FOXA1_25552417_ChIP-Seq_VCAP_Human0.85395803
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85233984
142RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85122190
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84924250
144FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84899077
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84817027
146WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84520983
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84193411
148CRX_20693478_ChIP-Seq_RETINA_Mouse0.83567220
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83552311
150P53_22387025_ChIP-Seq_ESCs_Mouse0.83346027
151OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83301284
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82873697
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82529946
154* BRD4_25478319_ChIP-Seq_HGPS_Human0.82396450
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81740600
156IRF8_22096565_ChIP-ChIP_GC-B_Human0.81662026
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.81632283
158CDX2_22108803_ChIP-Seq_LS180_Human0.81386817
159CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81336973
160CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80233582
161ZNF274_21170338_ChIP-Seq_K562_Hela0.80111236
162NFE2_27457419_Chip-Seq_LIVER_Mouse0.79836424
163TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79769775
164JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79618805
165FLI1_21867929_ChIP-Seq_TH2_Mouse0.79411732
166JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79369670
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79247020
168TP63_17297297_ChIP-ChIP_HaCaT_Human0.78874125
169GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78110372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.74469163
2MP0009780_abnormal_chondrocyte_physiolo3.61292091
3MP0001835_abnormal_antigen_presentation3.49657615
4MP0002909_abnormal_adrenal_gland3.18033589
5MP0002139_abnormal_hepatobiliary_system3.13192043
6MP0008438_abnormal_cutaneous_collagen3.12179412
7MP0010386_abnormal_urinary_bladder2.88854217
8MP0003303_peritoneal_inflammation2.88528394
9MP0003436_decreased_susceptibility_to2.86480125
10MP0005365_abnormal_bile_salt2.77540146
11MP0006082_CNS_inflammation2.59392342
12MP0002419_abnormal_innate_immunity2.48029481
13MP0009785_altered_susceptibility_to2.45485387
14MP0003828_pulmonary_edema2.44221848
15MP0005000_abnormal_immune_tolerance2.41606849
16MP0005671_abnormal_response_to2.40555233
17MP0001790_abnormal_immune_system2.39017161
18MP0005387_immune_system_phenotype2.39017161
19MP0000685_abnormal_immune_system2.36110422
20MP0002148_abnormal_hypersensitivity_rea2.35144613
21MP0001800_abnormal_humoral_immune2.34713216
22MP0006054_spinal_hemorrhage2.26433640
23MP0000013_abnormal_adipose_tissue2.20781393
24MP0005464_abnormal_platelet_physiology2.14935537
25MP0002723_abnormal_immune_serum2.14498361
26MP0005220_abnormal_exocrine_pancreas2.13721933
27MP0001944_abnormal_pancreas_morphology2.12277141
28MP0003183_abnormal_peptide_metabolism2.12128488
29MP0004043_abnormal_pH_regulation2.11361577
30MP0003283_abnormal_digestive_organ2.09752520
31MP0005085_abnormal_gallbladder_physiolo2.06985342
32MP0002452_abnormal_antigen_presenting2.06885429
33MP0005025_abnormal_response_to2.04225019
34MP0005275_abnormal_skin_tensile2.00614922
35MP0002693_abnormal_pancreas_physiology2.00340156
36MP0002132_abnormal_respiratory_system1.99764190
37MP0003705_abnormal_hypodermis_morpholog1.95395580
38MP0003195_calcinosis1.95024308
39MP0001666_abnormal_nutrient_absorption1.93238349
40MP0002420_abnormal_adaptive_immunity1.88899094
41MP0009764_decreased_sensitivity_to1.87509782
42MP0002837_dystrophic_cardiac_calcinosis1.86929700
43MP0001819_abnormal_immune_cell1.86558359
44MP0002896_abnormal_bone_mineralization1.86286104
45MP0003252_abnormal_bile_duct1.85790727
46MP0010234_abnormal_vibrissa_follicle1.84271441
47MP0003300_gastrointestinal_ulcer1.83489903
48MP0010155_abnormal_intestine_physiology1.72059842
49MP0005503_abnormal_tendon_morphology1.70188439
50MP0005360_urolithiasis1.69788257
51MP0003868_abnormal_feces_composition1.69346510
52MP0004947_skin_inflammation1.66479328
53MP0002405_respiratory_system_inflammati1.64728207
54MP0005058_abnormal_lysosome_morphology1.64100040
55MP0010329_abnormal_lipoprotein_level1.61326418
56MP0005646_abnormal_pituitary_gland1.60281715
57MP0000003_abnormal_adipose_tissue1.59114591
58MP0001845_abnormal_inflammatory_respons1.57390047
59MP0004782_abnormal_surfactant_physiolog1.55695293
60MP0002876_abnormal_thyroid_physiology1.53487127
61MP0005397_hematopoietic_system_phenotyp1.52268750
62MP0001545_abnormal_hematopoietic_system1.52268750
63MP0008875_abnormal_xenobiotic_pharmacok1.49757279
64MP0000465_gastrointestinal_hemorrhage1.47948765
65MP0002078_abnormal_glucose_homeostasis1.47891290
66MP0004130_abnormal_muscle_cell1.42847415
67MP0004883_abnormal_blood_vessel1.41236735
68MP0009278_abnormal_bone_marrow1.40286473
69MP0005164_abnormal_response_to1.36048641
70MP0000716_abnormal_immune_system1.34269565
71MP0005310_abnormal_salivary_gland1.34197633
72MP0003763_abnormal_thymus_physiology1.32380829
73MP0001986_abnormal_taste_sensitivity1.30116459
74MP0004484_altered_response_of1.27477448
75MP0009643_abnormal_urine_homeostasis1.26245334
76MP0008961_abnormal_basal_metabolism1.24660477
77MP0001765_abnormal_ion_homeostasis1.23306307
78MP0008469_abnormal_protein_level1.22149738
79MP0002398_abnormal_bone_marrow1.22000236
80MP0001958_emphysema1.21640068
81MP0002118_abnormal_lipid_homeostasis1.21527610
82MP0001851_eye_inflammation1.20805159
83MP0000538_abnormal_urinary_bladder1.19077448
84MP0005379_endocrine/exocrine_gland_phen1.16425226
85MP0000689_abnormal_spleen_morphology1.15915890
86MP0003959_abnormal_lean_body1.14807546
87MP0001853_heart_inflammation1.13409242
88MP0009333_abnormal_splenocyte_physiolog1.11851244
89MP0009384_cardiac_valve_regurgitation1.11671182
90MP0002006_tumorigenesis1.11522785
91MP0000343_altered_response_to1.11464868
92MP0004510_myositis1.10507617
93MP0005167_abnormal_blood-brain_barrier1.10356821
94MP0003690_abnormal_glial_cell1.08824698
95MP0001299_abnormal_eye_distance/1.08586953
96MP0001756_abnormal_urination1.08025237
97MP0002090_abnormal_vision1.07750066
98MP0004858_abnormal_nervous_system1.07739301
99MP0005332_abnormal_amino_acid1.07255357
100MP0000537_abnormal_urethra_morphology1.05944074
101MP0004233_abnormal_muscle_weight1.04447052
102MP0004270_analgesia1.04197964
103MP0002138_abnormal_hepatobiliary_system1.03833691
104MP0005083_abnormal_biliary_tract1.03336572
105MP0002254_reproductive_system_inflammat0.98471155
106MP0003172_abnormal_lysosome_physiology0.98124785
107MP0003221_abnormal_cardiomyocyte_apopto0.96038057
108MP0002722_abnormal_immune_system0.95737412
109MP0001177_atelectasis0.95569107
110MP0003866_abnormal_defecation0.95460319
111MP0002429_abnormal_blood_cell0.95333245
112MP0003953_abnormal_hormone_level0.95134612
113MP0004272_abnormal_basement_membrane0.94801456
114MP0003191_abnormal_cellular_cholesterol0.94019094
115MP0005166_decreased_susceptibility_to0.93794338
116MP0002060_abnormal_skin_morphology0.93643702
117MP0003045_fibrosis0.92464808
118MP0002295_abnormal_pulmonary_circulatio0.90341377
119MP0005375_adipose_tissue_phenotype0.89313092
120MP0000604_amyloidosis0.89272777
121MP0005535_abnormal_body_temperature0.87661735
122MP0001661_extended_life_span0.86820052
123MP0001533_abnormal_skeleton_physiology0.86606044
124MP0000609_abnormal_liver_physiology0.85013243
125MP0002332_abnormal_exercise_endurance0.84550033
126MP0005248_abnormal_Harderian_gland0.83868608
127MP0008260_abnormal_autophagy0.83851978
128MP0000230_abnormal_systemic_arterial0.82608392
129MP0002277_abnormal_respiratory_mucosa0.82280164
130MP0003329_amyloid_beta_deposits0.82013660
131MP0005645_abnormal_hypothalamus_physiol0.80735845
132MP0002115_abnormal_skeleton_extremities0.80207967
133MP0000249_abnormal_blood_vessel0.79649023
134MP0001270_distended_abdomen0.79448375
135MP0005448_abnormal_energy_balance0.78996244
136MP0008004_abnormal_stomach_pH0.78534931
137MP0000920_abnormal_myelination0.77171357
138MP0008874_decreased_physiological_sensi0.75612222
139MP0005388_respiratory_system_phenotype0.75004484
140MP0002133_abnormal_respiratory_system0.75004484
141MP0002009_preneoplasia0.74993810
142MP0005334_abnormal_fat_pad0.74738259
143MP0000681_abnormal_thyroid_gland0.74538436
144MP0005636_abnormal_mineral_homeostasis0.74252368
145MP0001502_abnormal_circadian_rhythm0.74068728
146MP0009763_increased_sensitivity_to0.73897088
147MP0002166_altered_tumor_susceptibility0.73526202
148MP0005390_skeleton_phenotype0.73509855
149MP0003566_abnormal_cell_adhesion0.73171669
150MP0000163_abnormal_cartilage_morphology0.73080240
151MP0003795_abnormal_bone_structure0.72917557
152MP0003656_abnormal_erythrocyte_physiolo0.72378366
153MP0001542_abnormal_bone_strength0.71870487
154MP0003091_abnormal_cell_migration0.71080499
155MP0009765_abnormal_xenobiotic_induced0.70925707
156MP0003279_aneurysm0.70749920
157MP0002998_abnormal_bone_remodeling0.70516789
158MP0000569_abnormal_digit_pigmentation0.69573907
159MP0005451_abnormal_body_composition0.69458960
160MP0009840_abnormal_foam_cell0.68977949
161MP0004084_abnormal_cardiac_muscle0.68201692
162MP0002168_other_aberrant_phenotype0.68128709
163MP0003075_altered_response_to0.68027536
164MP0000516_abnormal_urinary_system0.65741040
165MP0005367_renal/urinary_system_phenotyp0.65741040
166MP0002928_abnormal_bile_duct0.65062915
167MP0001501_abnormal_sleep_pattern0.64307928
168MP0003724_increased_susceptibility_to0.61503306
169MP0004036_abnormal_muscle_relaxation0.59944093

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.35408446
2Hypoglycemic seizures (HP:0002173)4.03455780
3Eczematoid dermatitis (HP:0000976)4.02453608
4Myositis (HP:0100614)3.92602060
5Elevated erythrocyte sedimentation rate (HP:0003565)3.91761968
6Orchitis (HP:0100796)3.87652351
7Optic neuritis (HP:0100653)3.85152782
8Retrobulbar optic neuritis (HP:0100654)3.85152782
9Abnormality of macrophages (HP:0004311)3.81315933
10Hypoglycemic coma (HP:0001325)3.80359634
11T lymphocytopenia (HP:0005403)3.59137079
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.56177261
13Hyperinsulinemic hypoglycemia (HP:0000825)3.55310675
14Recurrent abscess formation (HP:0002722)3.51766228
15Recurrent bacterial skin infections (HP:0005406)3.51628511
16Abnormality of liposaccharide metabolism (HP:0010968)3.41846773
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.41846773
18Abnormality of glycolipid metabolism (HP:0010969)3.41846773
19Abnormality of T cell number (HP:0011839)3.39082577
20Recurrent fungal infections (HP:0002841)3.36675876
21Symptomatic seizures (HP:0011145)3.35039148
22Mediastinal lymphadenopathy (HP:0100721)3.33761426
23Hyperglycemia (HP:0003074)3.30869246
24Panhypogammaglobulinemia (HP:0003139)3.26223901
25Insulin-resistant diabetes mellitus (HP:0000831)3.23277900
26Abnormality of the intrinsic pathway (HP:0010989)3.19422220
27Ketoacidosis (HP:0001993)3.17580931
28Spontaneous hematomas (HP:0007420)3.14447212
29Testicular neoplasm (HP:0010788)2.95415573
30Urinary glycosaminoglycan excretion (HP:0003541)2.95065108
31Mucopolysacchariduria (HP:0008155)2.95065108
32Vasculitis (HP:0002633)2.92930479
33Episodic fever (HP:0001954)2.88767151
34Gastrointestinal infarctions (HP:0005244)2.86938475
35Meningitis (HP:0001287)2.86549483
36Prolonged bleeding time (HP:0003010)2.82936192
37Recurrent gram-negative bacterial infections (HP:0005420)2.72963140
38Keratoconjunctivitis sicca (HP:0001097)2.70542653
39Gingival bleeding (HP:0000225)2.69056159
40Leukocytosis (HP:0001974)2.66707246
41Abnormality of the common coagulation pathway (HP:0010990)2.66479245
42Dysostosis multiplex (HP:0000943)2.65432258
43Abnormality of B cell number (HP:0010975)2.65287260
44Eosinophilia (HP:0001880)2.65136860
45Thyroiditis (HP:0100646)2.64022061
46Keratoconjunctivitis (HP:0001096)2.63225962
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.62390874
48Abnormality of polysaccharide metabolism (HP:0011012)2.60313793
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60313793
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60313793
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60105536
52Pulmonary infiltrates (HP:0002113)2.59713895
53Gonadal dysgenesis (HP:0000133)2.59574503
54Hemoptysis (HP:0002105)2.58505786
55Recurrent skin infections (HP:0001581)2.57383110
56Premature rupture of membranes (HP:0001788)2.56480517
57Recurrent cutaneous fungal infections (HP:0011370)2.56142803
58Chronic mucocutaneous candidiasis (HP:0002728)2.56142803
59Type II lissencephaly (HP:0007260)2.50576868
60Cerebellar dysplasia (HP:0007033)2.49144685
61Chronic obstructive pulmonary disease (HP:0006510)2.48468662
62Obstructive lung disease (HP:0006536)2.48468662
63Amyloidosis (HP:0011034)2.48460435
64Epiphyseal dysplasia (HP:0002656)2.47773609
65Increased cerebral lipofuscin (HP:0011813)2.47196178
66B lymphocytopenia (HP:0010976)2.47181993
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.44972246
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.44972246
69Hypoproteinemia (HP:0003075)2.43396112
70Buphthalmos (HP:0000557)2.42232692
71Abnormality of endocrine pancreas physiology (HP:0012093)2.41605872
72Abnormality of the pancreatic islet cells (HP:0006476)2.41605872
73Hypoplasia of the thymus (HP:0000778)2.41250963
74Congenital glaucoma (HP:0001087)2.41072323
75Recurrent viral infections (HP:0004429)2.38880167
76Peritonitis (HP:0002586)2.38344825
77Encephalitis (HP:0002383)2.36670584
78Protuberant abdomen (HP:0001538)2.35338059
79Granulocytopenia (HP:0001913)2.34855647
80Large for gestational age (HP:0001520)2.33270068
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.33199898
82Epistaxis (HP:0000421)2.32955822
83Ketosis (HP:0001946)2.31103408
84Abnormality of T cells (HP:0002843)2.28930680
85Loss of speech (HP:0002371)2.26058492
86Conjugated hyperbilirubinemia (HP:0002908)2.24500567
87Deep venous thrombosis (HP:0002625)2.24084139
88Xanthomatosis (HP:0000991)2.23793058
89Urticaria (HP:0001025)2.23055866
90Abnormality of calcium-phosphate metabolism (HP:0100530)2.20823752
91Pulmonary embolism (HP:0002204)2.20625658
92Disinhibition (HP:0000734)2.19071804
93Abnormality of the peritoneum (HP:0002585)2.12324678
94Mitral stenosis (HP:0001718)2.11880035
95Abnormality of eosinophils (HP:0001879)2.10185894
96Abnormality of the corticospinal tract (HP:0002492)2.09590936
97Complement deficiency (HP:0004431)2.09300325
98Fat malabsorption (HP:0002630)2.09244443
99Severe combined immunodeficiency (HP:0004430)2.08629311
100Hematochezia (HP:0002573)2.08471201
101Intrahepatic cholestasis (HP:0001406)2.07777119
102Late onset (HP:0003584)2.06507031
103Mesangial abnormality (HP:0001966)2.06095902
104Insulin resistance (HP:0000855)2.05033571
105Abnormal foot bone ossification (HP:0010675)2.04998629
106Petechiae (HP:0000967)2.04328005
107Chest pain (HP:0100749)2.02489597
108Cervical subluxation (HP:0003308)2.02441056
109Abnormal tarsal ossification (HP:0008369)2.02284383
110Disproportionate short-trunk short stature (HP:0003521)2.02209598
111Gingivitis (HP:0000230)2.02134191
112Abnormality of the pleura (HP:0002103)2.01839007
113Arterial thrombosis (HP:0004420)2.01372382
114Skin nodule (HP:0200036)2.01055384
115Agitation (HP:0000713)1.99235205
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98810526
117Gangrene (HP:0100758)1.98565201
118Gout (HP:0001997)1.97999599
119Hydroxyprolinuria (HP:0003080)1.97837163
120Abnormality of proline metabolism (HP:0010907)1.97837163
121Pancreatic islet-cell hyperplasia (HP:0004510)1.97659734
122Pheochromocytoma (HP:0002666)1.95856272
123Polyneuropathy (HP:0001271)1.95510956
124Ovoid vertebral bodies (HP:0003300)1.95378521
125Beaking of vertebral bodies (HP:0004568)1.94438713
126Central scotoma (HP:0000603)1.94083179
127Autoimmune thrombocytopenia (HP:0001973)1.94005973
128Amyotrophic lateral sclerosis (HP:0007354)1.93915217
129Vacuolated lymphocytes (HP:0001922)1.92762103
130Stomach cancer (HP:0012126)1.91358363
131Joint swelling (HP:0001386)1.90124968
132Glomerulopathy (HP:0100820)1.89404758
133Hyperactive renin-angiotensin system (HP:0000841)1.89261416
134Bundle branch block (HP:0011710)1.86901136
135Thoracolumbar scoliosis (HP:0002944)1.86882425
136Anomalous pulmonary venous return (HP:0010772)1.86045092
137Abdominal distention (HP:0003270)1.85936754
138Hypercortisolism (HP:0001578)1.82720492
139Asymmetry of the thorax (HP:0001555)1.82569789
140Abolished electroretinogram (ERG) (HP:0000550)1.81585767
141Dysautonomia (HP:0002459)1.80772320
142Increased IgE level (HP:0003212)1.80751923
143Neoplasm of the tracheobronchial system (HP:0100552)1.79989666
144Irregular vertebral endplates (HP:0003301)1.79732678
145Osteomyelitis (HP:0002754)1.79526826
146Inflammation of the large intestine (HP:0002037)1.78074762
147Lymphangioma (HP:0100764)1.74353612
148Osteoarthritis (HP:0002758)1.74342143
149Increased CSF protein (HP:0002922)1.74198174
150Alveolar cell carcinoma (HP:0006519)1.73457776
151Abnormality of glutamine family amino acid metabolism (HP:0010902)1.71877551
152Abnormality of the pericardium (HP:0001697)1.70269345
153Agammaglobulinemia (HP:0004432)1.70207542
154Chronic diarrhea (HP:0002028)1.70019873
155Protrusio acetabuli (HP:0003179)1.69739655
156Bradycardia (HP:0001662)1.69690326
157Papillary thyroid carcinoma (HP:0002895)1.69239260
158Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68757730
159Hypoplastic ischia (HP:0003175)1.68590348
160Lower limb asymmetry (HP:0100559)1.68181108
161Abnormality of purine metabolism (HP:0004352)1.67292912
162Abnormality of the ischium (HP:0003174)1.67086343
163Hand muscle atrophy (HP:0009130)1.66589398
164Glucose intolerance (HP:0000833)1.66441248
165Termporal pattern (HP:0011008)1.66260841
166Insidious onset (HP:0003587)1.66260841
167Abnormal pancreas size (HP:0012094)1.65878748
168Craniofacial hyperostosis (HP:0004493)1.65343866
169Abnormality of the distal phalanges of the toes (HP:0010182)1.64365108
170Cortical dysplasia (HP:0002539)1.64215588
171Growth hormone excess (HP:0000845)1.64208393
172Atrophic scars (HP:0001075)1.63809126
173Myocardial infarction (HP:0001658)1.62289353
174Prolonged partial thromboplastin time (HP:0003645)1.61681595
175Neuroendocrine neoplasm (HP:0100634)1.61178633
176Macroorchidism (HP:0000053)1.60733086
177Abnormality of the vertebral endplates (HP:0005106)1.58816896
178Cupped ribs (HP:0000887)1.58307680
179Papilledema (HP:0001085)1.56533024
180Broad ribs (HP:0000885)1.55645584
181Platyspondyly (HP:0000926)1.55607879
182Ectopia lentis (HP:0001083)1.55462985
183Epidermoid cyst (HP:0200040)1.55309367
184Aortic dissection (HP:0002647)1.55024840
185Abnormality of complement system (HP:0005339)1.53313780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.68829723
2RIPK43.46126962
3BCKDK3.25548016
4PIK3CG3.04975945
5INSRR2.59329375
6TRIB32.53869161
7BMPR22.45926173
8TXK2.36359656
9LATS12.31984943
10TAOK32.25686345
11MAP3K22.25325229
12FLT32.14228128
13AKT32.13914330
14IRAK42.13376175
15EPHA32.09777303
16CAMKK11.86194923
17IKBKE1.85304533
18PDGFRA1.84793372
19FER1.80745550
20SIK11.79656849
21FES1.79137459
22MAP2K31.73404736
23BLK1.69714246
24CSK1.66396311
25ERN11.63278352
26SGK21.63000563
27GRK71.61400151
28SGK31.57942663
29MAP3K61.52636090
30RET1.50490106
31ERBB31.50263203
32DAPK21.48833207
33NTRK11.48084322
34KIT1.47038888
35FGFR31.46421303
36DDR21.44439686
37FGFR41.43746424
38TBK11.39816972
39YES11.38371731
40SYK1.37144376
41MAP3K31.35527032
42SCYL21.35487831
43CAMKK21.35167947
44MAP4K11.34937208
45IKBKB1.34344080
46BTK1.33017344
47DYRK1B1.32808755
48PTK61.31431149
49TNK21.30206807
50RIPK11.29818268
51UHMK11.29802118
52SGK2231.29793872
53SGK4941.29793872
54PIK3CA1.29460011
55IRAK21.27361693
56JAK11.25963903
57TEC1.23276750
58MET1.22460876
59PASK1.21949791
60WNK41.20018104
61PRKCH1.17767023
62SIK31.17256278
63FGFR21.17122675
64HCK1.13296550
65LYN1.12046209
66PINK11.11084431
67MAP3K131.10650078
68PRKD31.08294703
69PDGFRB1.06998202
70NTRK31.06906783
71HIPK21.06145125
72PKN21.05972271
73MAPK151.03537358
74ADRBK21.01131641
75IRAK11.00820588
76GRK61.00652027
77TESK11.00324075
78ACVR1B0.99761127
79EPHB10.95284240
80FGR0.93540858
81LMTK20.92854499
82PTK20.92690041
83ITK0.92568136
84PRKD20.91535598
85JAK20.91277728
86CSF1R0.91072016
87MAPK70.90108949
88STK380.89067843
89WNK10.87780819
90MAPK120.85804655
91LCK0.85371788
92MATK0.83618149
93NUAK10.82584957
94MAP3K50.82465758
95GSK3A0.81292185
96PRKCE0.80320942
97MARK10.77958436
98PAK30.73942304
99PRKCQ0.73509815
100TAOK10.73407364
101MARK30.72128856
102MARK20.71019500
103JAK30.68038614
104MAP3K140.65701865
105STK240.65371528
106CHUK0.64624229
107MAP2K10.63713286
108KSR20.63253066
109RPS6KA60.60492736
110GRK10.60151799
111MYLK0.58234024
112RPS6KC10.57823574
113RPS6KL10.57823574
114IGF1R0.56706283
115TYK20.55428770
116NEK90.55227879
117CASK0.54782992
118TRPM70.54280558
119ABL10.53930949
120BMPR1B0.53815890
121RPS6KA20.52196943
122TTN0.51091157
123LRRK20.49976429
124CDK190.49933308
125ROCK10.49695760
126IRAK30.48008561
127MAP3K70.47927772
128CDK50.44554764
129MAP3K10.44132246
130ADRBK10.43865881
131MAP2K60.43641797
132MST1R0.43429285
133MAP3K40.43388533
134FYN0.41766610
135PRKAA10.39429541
136DYRK1A0.38682158
137PRKD10.37399669
138SGK10.35925665
139ERBB40.35580987
140STK38L0.35298647
141PTK2B0.35288160
142PAK20.33753830
143PDPK10.32779936
144STK30.32773743
145WNK30.31980152
146MINK10.31582664
147MAP2K40.31188339
148ZAP700.29562217
149PRKG20.29365705
150RPS6KB10.29246388
151TGFBR20.29206349
152PRKACG0.28774967
153PDK10.28417118
154FGFR10.28206038
155NLK0.27734076
156MAP3K100.27209224
157PRPF4B0.26927084

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.75982979
2Sulfur metabolism_Homo sapiens_hsa009202.95991040
3Staphylococcus aureus infection_Homo sapiens_hsa051502.28458500
4Leishmaniasis_Homo sapiens_hsa051402.27621963
5Osteoclast differentiation_Homo sapiens_hsa043802.21723938
6Graft-versus-host disease_Homo sapiens_hsa053322.13025103
7Allograft rejection_Homo sapiens_hsa053302.09141615
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07932999
9Autoimmune thyroid disease_Homo sapiens_hsa053201.96531584
10Protein export_Homo sapiens_hsa030601.88816907
11Tuberculosis_Homo sapiens_hsa051521.86676917
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79366887
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78332165
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.74805455
15Nitrogen metabolism_Homo sapiens_hsa009101.74263641
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.70639264
17Asthma_Homo sapiens_hsa053101.69541205
18B cell receptor signaling pathway_Homo sapiens_hsa046621.65093263
19Rheumatoid arthritis_Homo sapiens_hsa053231.63960402
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56679461
21Type II diabetes mellitus_Homo sapiens_hsa049301.54078648
22Insulin secretion_Homo sapiens_hsa049111.51277727
23Hematopoietic cell lineage_Homo sapiens_hsa046401.47498349
24Primary immunodeficiency_Homo sapiens_hsa053401.46204461
25Fatty acid degradation_Homo sapiens_hsa000711.44660611
26Malaria_Homo sapiens_hsa051441.40961531
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40180461
28N-Glycan biosynthesis_Homo sapiens_hsa005101.36814673
29Tryptophan metabolism_Homo sapiens_hsa003801.35792056
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34556070
31Vibrio cholerae infection_Homo sapiens_hsa051101.34130328
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32832143
33Toxoplasmosis_Homo sapiens_hsa051451.30206424
34Legionellosis_Homo sapiens_hsa051341.28017331
35Lysosome_Homo sapiens_hsa041421.26883968
36Fatty acid metabolism_Homo sapiens_hsa012121.26818742
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.25426108
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25192266
39Chemokine signaling pathway_Homo sapiens_hsa040621.24391611
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24322706
41Insulin resistance_Homo sapiens_hsa049311.24321416
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24095952
43Other glycan degradation_Homo sapiens_hsa005111.23261795
44Butanoate metabolism_Homo sapiens_hsa006501.21748357
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21622813
46T cell receptor signaling pathway_Homo sapiens_hsa046601.21372660
47TNF signaling pathway_Homo sapiens_hsa046681.20478259
48Platelet activation_Homo sapiens_hsa046111.16805147
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.13540933
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11763429
51Measles_Homo sapiens_hsa051621.11683265
52Antigen processing and presentation_Homo sapiens_hsa046121.11023148
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10568836
54Pertussis_Homo sapiens_hsa051331.10212509
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09315139
56Arginine biosynthesis_Homo sapiens_hsa002201.07837413
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07138558
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05428815
59Protein digestion and absorption_Homo sapiens_hsa049741.05204012
60Influenza A_Homo sapiens_hsa051641.04173093
61Viral myocarditis_Homo sapiens_hsa054161.03130777
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02684290
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01410661
64Selenocompound metabolism_Homo sapiens_hsa004501.00349946
65Complement and coagulation cascades_Homo sapiens_hsa046101.00109961
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99068659
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97502198
68PPAR signaling pathway_Homo sapiens_hsa033200.94433616
69Collecting duct acid secretion_Homo sapiens_hsa049660.92874652
70Fat digestion and absorption_Homo sapiens_hsa049750.91892357
71Starch and sucrose metabolism_Homo sapiens_hsa005000.91477253
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91468451
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91066741
74Pancreatic secretion_Homo sapiens_hsa049720.88988645
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88610813
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88197346
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86414676
78Prolactin signaling pathway_Homo sapiens_hsa049170.84980089
79Synaptic vesicle cycle_Homo sapiens_hsa047210.82879961
80Fatty acid elongation_Homo sapiens_hsa000620.82643622
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82199825
82Hepatitis C_Homo sapiens_hsa051600.82081670
83Circadian rhythm_Homo sapiens_hsa047100.81651851
84Acute myeloid leukemia_Homo sapiens_hsa052210.80808790
85Type I diabetes mellitus_Homo sapiens_hsa049400.79074769
86Propanoate metabolism_Homo sapiens_hsa006400.78973442
87FoxO signaling pathway_Homo sapiens_hsa040680.77493570
88African trypanosomiasis_Homo sapiens_hsa051430.75806468
89Thyroid hormone synthesis_Homo sapiens_hsa049180.74685065
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.73596403
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72951663
92Focal adhesion_Homo sapiens_hsa045100.72453214
93Hepatitis B_Homo sapiens_hsa051610.71931820
94Long-term depression_Homo sapiens_hsa047300.71071331
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71059736
96ECM-receptor interaction_Homo sapiens_hsa045120.70714208
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70492499
98Salmonella infection_Homo sapiens_hsa051320.70201349
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70122711
100Dorso-ventral axis formation_Homo sapiens_hsa043200.69529638
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69070916
102AMPK signaling pathway_Homo sapiens_hsa041520.68871185
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.68640900
104Amoebiasis_Homo sapiens_hsa051460.68524444
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68451377
106Herpes simplex infection_Homo sapiens_hsa051680.68315313
107Prion diseases_Homo sapiens_hsa050200.67878542
108Bile secretion_Homo sapiens_hsa049760.67399258
109Peroxisome_Homo sapiens_hsa041460.67254934
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66468430
111VEGF signaling pathway_Homo sapiens_hsa043700.66137517
112mTOR signaling pathway_Homo sapiens_hsa041500.65664210
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.65289762
114Endometrial cancer_Homo sapiens_hsa052130.65282222
115Cholinergic synapse_Homo sapiens_hsa047250.64605259
116Cocaine addiction_Homo sapiens_hsa050300.64350610
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64163641
118Shigellosis_Homo sapiens_hsa051310.64079261
119MAPK signaling pathway_Homo sapiens_hsa040100.63304979
120Phenylalanine metabolism_Homo sapiens_hsa003600.63103993
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62874670
122Inositol phosphate metabolism_Homo sapiens_hsa005620.62724279
123Glucagon signaling pathway_Homo sapiens_hsa049220.60770005
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59660907
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59581964
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59258436
127ABC transporters_Homo sapiens_hsa020100.57858317
128Phagosome_Homo sapiens_hsa041450.57848250
129Ether lipid metabolism_Homo sapiens_hsa005650.57823215
130Estrogen signaling pathway_Homo sapiens_hsa049150.57506661
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57194593
132GnRH signaling pathway_Homo sapiens_hsa049120.56521474
133Linoleic acid metabolism_Homo sapiens_hsa005910.56512377
134Insulin signaling pathway_Homo sapiens_hsa049100.55436584
135GABAergic synapse_Homo sapiens_hsa047270.54966227
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53845924
137Dopaminergic synapse_Homo sapiens_hsa047280.53791882
138Glioma_Homo sapiens_hsa052140.53775545
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.53412022
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53305963
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51784727
142Renin secretion_Homo sapiens_hsa049240.51403532
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51266007
144Choline metabolism in cancer_Homo sapiens_hsa052310.50421253
145Arachidonic acid metabolism_Homo sapiens_hsa005900.49700465
146Taste transduction_Homo sapiens_hsa047420.49433990
147Circadian entrainment_Homo sapiens_hsa047130.49425001
148Renal cell carcinoma_Homo sapiens_hsa052110.47391023
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.47293663
150Ras signaling pathway_Homo sapiens_hsa040140.46758697
151Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46180135
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46027355
153Steroid biosynthesis_Homo sapiens_hsa001000.45697532
1542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45491193
155Amphetamine addiction_Homo sapiens_hsa050310.45136488
156Pancreatic cancer_Homo sapiens_hsa052120.45105102
157Vascular smooth muscle contraction_Homo sapiens_hsa042700.43986326
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43951304
159Non-small cell lung cancer_Homo sapiens_hsa052230.43812357
160Long-term potentiation_Homo sapiens_hsa047200.43419940
161Neurotrophin signaling pathway_Homo sapiens_hsa047220.42771156
162Caffeine metabolism_Homo sapiens_hsa002320.41789449
163Renin-angiotensin system_Homo sapiens_hsa046140.40816536
164Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40594982
165Sphingolipid metabolism_Homo sapiens_hsa006000.40507848
166Folate biosynthesis_Homo sapiens_hsa007900.39806950
167Central carbon metabolism in cancer_Homo sapiens_hsa052300.39684694
168Regulation of autophagy_Homo sapiens_hsa041400.39315539
169Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38897082
170Histidine metabolism_Homo sapiens_hsa003400.38864438
171Tyrosine metabolism_Homo sapiens_hsa003500.38337203
172Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38203325
173Endocytosis_Homo sapiens_hsa041440.36392797

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