TMEM168

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57683916
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.01438275
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01438275
4antigen processing and presentation of endogenous antigen (GO:0019883)5.00697469
5intestinal epithelial cell development (GO:0060576)4.89695155
6auditory receptor cell differentiation (GO:0042491)4.63408987
7signal peptide processing (GO:0006465)4.46095717
8regulation of interleukin-12 biosynthetic process (GO:0045075)4.32612373
9magnesium ion transport (GO:0015693)4.24811799
10neural tube formation (GO:0001841)4.09128299
11positive regulation of gamma-delta T cell activation (GO:0046645)4.01058418
12positive regulation of interferon-alpha production (GO:0032727)3.91792596
13regulation of protein glycosylation (GO:0060049)3.87371064
14prenylation (GO:0097354)3.85619632
15protein prenylation (GO:0018342)3.85619632
16regulation of interferon-beta biosynthetic process (GO:0045357)3.84423611
17interkinetic nuclear migration (GO:0022027)3.78578402
18positive regulation of glycoprotein biosynthetic process (GO:0010560)3.74280203
19branched-chain amino acid catabolic process (GO:0009083)3.73948089
20establishment of protein localization to Golgi (GO:0072600)3.71339178
21modulation by symbiont of host defense response (GO:0052031)3.70576887
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70576887
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70576887
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.70576887
25modulation by symbiont of host immune response (GO:0052553)3.70576887
26positive regulation by symbiont of host defense response (GO:0052509)3.70576887
27regulation of interferon-alpha production (GO:0032647)3.68547307
28neutrophil activation involved in immune response (GO:0002283)3.67596378
29negative regulation of mast cell activation (GO:0033004)3.63669874
30NIK/NF-kappaB signaling (GO:0038061)3.61711917
31T-helper 1 type immune response (GO:0042088)3.47143060
32bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44507692
33cellular response to zinc ion (GO:0071294)3.40586702
34positive regulation of natural killer cell differentiation (GO:0032825)3.40451360
35positive regulation of interleukin-12 production (GO:0032735)3.37625617
36immunoglobulin mediated immune response (GO:0016064)3.36515823
37response to muramyl dipeptide (GO:0032495)3.32903320
38protein targeting to vacuole (GO:0006623)3.29546849
39protein targeting to lysosome (GO:0006622)3.29546849
40establishment of protein localization to vacuole (GO:0072666)3.29546849
41natural killer cell mediated cytotoxicity (GO:0042267)3.29209680
42natural killer cell mediated immunity (GO:0002228)3.29209680
43DNA demethylation (GO:0080111)3.27474196
44regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.27345917
45prostate gland growth (GO:0060736)3.25989251
46negative regulation of systemic arterial blood pressure (GO:0003085)3.24675071
47myeloid dendritic cell differentiation (GO:0043011)3.22023662
48positive regulation of antigen processing and presentation (GO:0002579)3.21039538
49iron ion import (GO:0097286)3.19139195
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19101843
51myeloid dendritic cell activation (GO:0001773)3.17203591
52protein targeting to Golgi (GO:0000042)3.15679132
53JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.15652943
54ketone body metabolic process (GO:1902224)3.15179981
55regulation of T-helper 1 cell differentiation (GO:0045625)3.15110771
56regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.12321002
57positive regulation of interferon-beta production (GO:0032728)3.12202540
58pyrimidine-containing compound transmembrane transport (GO:0072531)3.12088792
59Arp2/3 complex-mediated actin nucleation (GO:0034314)3.11649151
60lipid translocation (GO:0034204)3.11447880
61phospholipid translocation (GO:0045332)3.11447880
62phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.08617735
63negative regulation of execution phase of apoptosis (GO:1900118)3.08203561
64cellular ketone body metabolic process (GO:0046950)3.07996341
65Golgi to endosome transport (GO:0006895)3.06428217
66preassembly of GPI anchor in ER membrane (GO:0016254)3.06233170
67hair cell differentiation (GO:0035315)3.05853749
68sulfate transmembrane transport (GO:1902358)3.05010385
69response to pheromone (GO:0019236)3.04734744
70regulation of B cell receptor signaling pathway (GO:0050855)3.04341850
71early endosome to late endosome transport (GO:0045022)3.02806613
72growth hormone receptor signaling pathway (GO:0060396)3.02267557
73positive regulation of glycoprotein metabolic process (GO:1903020)3.01713683
74regulation of B cell differentiation (GO:0045577)3.01500955
75neutrophil activation (GO:0042119)2.99742171
76positive regulation of B cell differentiation (GO:0045579)2.97379645
77production of molecular mediator involved in inflammatory response (GO:0002532)2.96964129
78response to type I interferon (GO:0034340)2.96841127
79type I interferon signaling pathway (GO:0060337)2.96383203
80cellular response to type I interferon (GO:0071357)2.96383203
81replication fork processing (GO:0031297)2.96274127
82DNA integration (GO:0015074)2.96032200
83histone mRNA catabolic process (GO:0071044)2.95136368
84cilium or flagellum-dependent cell motility (GO:0001539)2.94854792
85branched-chain amino acid metabolic process (GO:0009081)2.94757793
86phosphatidylserine acyl-chain remodeling (GO:0036150)2.93607640
87interferon-gamma-mediated signaling pathway (GO:0060333)2.93333309
88retrograde transport, vesicle recycling within Golgi (GO:0000301)2.92551127
89response to peptidoglycan (GO:0032494)2.91164097
90B cell mediated immunity (GO:0019724)2.90358824
91rRNA catabolic process (GO:0016075)2.89311039
92interleukin-6-mediated signaling pathway (GO:0070102)2.87594651
93regulation of antigen processing and presentation (GO:0002577)2.87373965
94low-density lipoprotein particle clearance (GO:0034383)2.85907716
95resolution of meiotic recombination intermediates (GO:0000712)2.85483416
96positive regulation of granulocyte differentiation (GO:0030854)2.85424363
97cytidine metabolic process (GO:0046087)2.85109856
98cytidine catabolic process (GO:0006216)2.85109856
99cytidine deamination (GO:0009972)2.85109856
100granulocyte activation (GO:0036230)2.84665510
101keratinocyte development (GO:0003334)2.84402725
102sulfate transport (GO:0008272)2.82414869
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81777263
104regulation of alpha-beta T cell proliferation (GO:0046640)2.81552978
105antigen processing and presentation via MHC class Ib (GO:0002475)2.80739071
106regulation of interleukin-12 production (GO:0032655)2.79911381
107regulation of cholesterol storage (GO:0010885)2.79673927
108regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.79196149
109regulation of gamma-delta T cell differentiation (GO:0045586)2.79195998
110retinal rod cell development (GO:0046548)2.78692347
111regulation of gamma-delta T cell activation (GO:0046643)2.78127288
112DNA deamination (GO:0045006)2.77527568
113artery development (GO:0060840)2.77506943
114positive regulation of glycolytic process (GO:0045821)2.77494758
115hepatocyte apoptotic process (GO:0097284)2.77373124
116response to interferon-alpha (GO:0035455)2.75967742
117regulation of keratinocyte proliferation (GO:0010837)2.75838675
118positive regulation of alpha-beta T cell proliferation (GO:0046641)2.74956236
119regulation of pigment cell differentiation (GO:0050932)2.74450614
120fatty acid elongation (GO:0030497)2.74346106
121DNA dealkylation (GO:0035510)2.73618765
122dendritic cell differentiation (GO:0097028)2.72791103
123piRNA metabolic process (GO:0034587)2.72227971
124regulation of T cell tolerance induction (GO:0002664)2.71573718
125positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.71221118
126macrophage activation involved in immune response (GO:0002281)2.70638178
127response to interferon-beta (GO:0035456)2.70203508
128negative regulation of interleukin-17 production (GO:0032700)2.69065556
129adenosine metabolic process (GO:0046085)2.68074030
130defense response to protozoan (GO:0042832)2.67440836
131replicative senescence (GO:0090399)2.67026839
132cytokine secretion (GO:0050663)2.66380516
133positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.66224867
134positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.65763908
135natural killer cell differentiation (GO:0001779)2.65460358
136DNA double-strand break processing (GO:0000729)2.65272360
137negative regulation of phagocytosis (GO:0050765)2.63887464
138terpenoid biosynthetic process (GO:0016114)2.63581952
139desmosome organization (GO:0002934)2.62902640
140pigment cell differentiation (GO:0050931)2.61810439
141positive regulation of phosphatase activity (GO:0010922)2.60366429
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.59335500
143melanocyte differentiation (GO:0030318)2.58624197
144cilium morphogenesis (GO:0060271)2.58539784
145cellular response to interferon-beta (GO:0035458)2.58275332
146pyrimidine ribonucleoside catabolic process (GO:0046133)2.58104486
147cellular response to growth hormone stimulus (GO:0071378)2.57019948
148sphingoid metabolic process (GO:0046519)2.55136605
149positive regulation of humoral immune response (GO:0002922)2.55069179
150negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53961354
151proline transport (GO:0015824)2.53671498
152UDP-N-acetylglucosamine metabolic process (GO:0006047)2.53531816
153water-soluble vitamin biosynthetic process (GO:0042364)2.52979454
154developmental pigmentation (GO:0048066)2.52638850
155negative thymic T cell selection (GO:0045060)2.51950024
156photoreceptor cell maintenance (GO:0045494)2.51907275
157sulfation (GO:0051923)2.51823482
158phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.51109523
159axoneme assembly (GO:0035082)2.50424533
160S-adenosylmethionine metabolic process (GO:0046500)2.50136369
161response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48824750
162response to host immune response (GO:0052572)2.48824750
163response to protozoan (GO:0001562)2.48608109
164phosphatidylinositol acyl-chain remodeling (GO:0036149)2.48569376
165positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48430264
166positive regulation of macrophage differentiation (GO:0045651)2.48416407
167ubiquinone biosynthetic process (GO:0006744)2.48266399
168inner ear receptor cell differentiation (GO:0060113)2.47902451
169respiratory burst (GO:0045730)2.47305387
170regulation of relaxation of muscle (GO:1901077)2.47258242
171pinocytosis (GO:0006907)2.47249905
172regulation of response to interferon-gamma (GO:0060330)2.47232571
173positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.47102193
174positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.46650348
175fucose catabolic process (GO:0019317)2.46302564
176L-fucose metabolic process (GO:0042354)2.46302564
177L-fucose catabolic process (GO:0042355)2.46302564
178regulation of hypersensitivity (GO:0002883)2.45853155
179positive regulation of developmental pigmentation (GO:0048087)2.44903918
180vascular smooth muscle contraction (GO:0014829)2.44862684
181retinal cone cell development (GO:0046549)2.44819866
182positive regulation of natural killer cell activation (GO:0032816)2.44681468
183cell adhesion mediated by integrin (GO:0033627)2.44563553
184positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.43971920
185RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.43788571
186positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.43045695
187B cell receptor signaling pathway (GO:0050853)2.42966055
188regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42954936
189regulation of memory T cell differentiation (GO:0043380)2.42083115
190response to host (GO:0075136)2.41796617
191response to host defenses (GO:0052200)2.41796617
192response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.41796617
193genitalia morphogenesis (GO:0035112)2.41501285
194regulation of tolerance induction (GO:0002643)2.41144298
195positive regulation of cytokine biosynthetic process (GO:0042108)2.40429090
196definitive hemopoiesis (GO:0060216)2.39987490
197regulation of natural killer cell differentiation (GO:0032823)2.39911255
198regulation of interferon-beta production (GO:0032648)2.39819452
199negative T cell selection (GO:0043383)2.39769196
200intra-Golgi vesicle-mediated transport (GO:0006891)2.39034143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.56821882
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.70491416
3* IRF8_21731497_ChIP-ChIP_J774_Mouse4.68113629
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.67786592
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.34463179
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.27300782
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16944733
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08624108
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03141246
10POU3F2_20337985_ChIP-ChIP_501MEL_Human3.02021484
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97682550
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96322217
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.83622366
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.80119871
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75892734
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.74316371
17VDR_22108803_ChIP-Seq_LS180_Human2.63225243
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56501839
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52166272
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.49483102
21IGF1R_20145208_ChIP-Seq_DFB_Human2.49337332
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.45610639
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40256583
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.40220576
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.26641503
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.25359714
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23018974
28* FUS_26573619_Chip-Seq_HEK293_Human2.22926259
29TP63_17297297_ChIP-ChIP_HaCaT_Human2.21236323
30GATA1_22025678_ChIP-Seq_K562_Human2.20934748
31TAF15_26573619_Chip-Seq_HEK293_Human2.18917627
32ZNF274_21170338_ChIP-Seq_K562_Hela2.18575566
33PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12921704
34GBX2_23144817_ChIP-Seq_PC3_Human2.10759625
35* ER_23166858_ChIP-Seq_MCF-7_Human2.10251461
36RUNX_20019798_ChIP-Seq_JUKART_Human2.06775672
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03065965
38BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02427743
39* MYB_26560356_Chip-Seq_TH2_Human1.99214824
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97981839
41* SPI1_23547873_ChIP-Seq_NB4_Human1.96858321
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94209394
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.91737321
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89746965
45EWS_26573619_Chip-Seq_HEK293_Human1.88356703
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87477547
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.86537070
48E2F7_22180533_ChIP-Seq_HELA_Human1.86509871
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84693831
50* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84417881
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78229874
52P300_19829295_ChIP-Seq_ESCs_Human1.75056173
53MYB_26560356_Chip-Seq_TH1_Human1.74835433
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74000925
55MAF_26560356_Chip-Seq_TH1_Human1.73779953
56CLOCK_20551151_ChIP-Seq_293T_Human1.71894963
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70327772
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69288427
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.67960298
60SCL_19346495_ChIP-Seq_HPC-7_Human1.67830008
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.66941554
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61185879
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61170697
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61011632
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.59574835
66SMAD4_21799915_ChIP-Seq_A2780_Human1.59389260
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.58690348
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57128112
69PU_27001747_Chip-Seq_BMDM_Mouse1.56647930
70STAT3_23295773_ChIP-Seq_U87_Human1.56351737
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55313075
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55313075
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53446619
74VDR_24763502_ChIP-Seq_THP-1_Human1.53220027
75VDR_21846776_ChIP-Seq_THP-1_Human1.52548894
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52536359
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52302113
78BCAT_22108803_ChIP-Seq_LS180_Human1.51506317
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.50796198
80CDX2_22108803_ChIP-Seq_LS180_Human1.50181969
81* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48484837
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.47830930
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45874681
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45517561
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45076394
86ELK1_19687146_ChIP-ChIP_HELA_Human1.44529842
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43384048
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42445564
89MYC_22102868_ChIP-Seq_BL_Human1.42426981
90P53_22387025_ChIP-Seq_ESCs_Mouse1.41278434
91SPI1_23127762_ChIP-Seq_K562_Human1.40884938
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39195983
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39140378
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.36239727
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.35760519
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35444087
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34459400
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33485029
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32757700
100* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32747603
101GATA3_27048872_Chip-Seq_THYMUS_Human1.32299935
102VDR_24787735_ChIP-Seq_THP-1_Human1.32060428
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31800582
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30877833
105RXR_22158963_ChIP-Seq_LIVER_Mouse1.29616259
106TCF4_23295773_ChIP-Seq_U87_Human1.29173405
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29115664
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28997960
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28550479
110OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28006493
111CBP_20019798_ChIP-Seq_JUKART_Human1.27126705
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27126705
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27034854
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26939351
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.26867601
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.25954340
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.25776749
118P300_18555785_Chip-Seq_ESCs_Mouse1.25360202
119AR_25329375_ChIP-Seq_VCAP_Human1.24224220
120TCF4_22108803_ChIP-Seq_LS180_Human1.23987103
121PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23708904
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.23361290
123AHR_22903824_ChIP-Seq_MCF-7_Human1.23297436
124UTX_26944678_Chip-Seq_JUKART_Human1.22790546
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21751684
126TCF7_22412390_ChIP-Seq_EML_Mouse1.19288703
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18923338
128TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17971558
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17938985
130SOX2_19829295_ChIP-Seq_ESCs_Human1.17643343
131NANOG_19829295_ChIP-Seq_ESCs_Human1.17643343
132OCT4_18555785_Chip-Seq_ESCs_Mouse1.17536738
133CJUN_26792858_Chip-Seq_BT549_Human1.17454713
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16868294
135FOXO3_23340844_ChIP-Seq_DLD1_Human1.16564018
136MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15982115
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15518617
138LXR_22158963_ChIP-Seq_LIVER_Mouse1.14036505
139TP53_16413492_ChIP-PET_HCT116_Human1.13807906
140FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13627736
141E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13267525
142EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12811931
143NOTCH1_21737748_ChIP-Seq_TLL_Human1.12723307
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12681367
145RUNX2_22187159_ChIP-Seq_PCA_Human1.12388037
146CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12278469
147TP63_23658742_ChIP-Seq_EP156T_Human1.12043473
148TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12037915
149SOX2_18555785_Chip-Seq_ESCs_Mouse1.12029510
150ARNT_22903824_ChIP-Seq_MCF-7_Human1.11956602
151GATA3_26560356_Chip-Seq_TH2_Human1.11834418
152BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11510309
153PRDM14_20953172_ChIP-Seq_ESCs_Human1.11452428
154E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11316492
155PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10899651
156RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09982891
157SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09612117
158SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09612117
159FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08670578
160SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08547626
161CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08016344
162EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07448054
163ELK3_25401928_ChIP-Seq_HUVEC_Human1.06063855
164MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05702639
165TFEB_21752829_ChIP-Seq_HELA_Human1.05403138
166* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04925124
167FLI1_21867929_ChIP-Seq_TH2_Mouse1.04600858
168ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02520630
169NMYC_18555785_Chip-Seq_ESCs_Mouse1.02399592
170TAL1_26923725_Chip-Seq_HPCs_Mouse1.02359822
171TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00049663
172HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99249490
173VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99108129
174GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98436519
175KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98148061
176KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97646534
177SMAD_19615063_ChIP-ChIP_OVARY_Human0.97587721
178WT1_19549856_ChIP-ChIP_CCG9911_Human0.96442006
179SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94106500
180RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93689537
181NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93239274
182RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92438554
183TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91837993
184MAF_26560356_Chip-Seq_TH2_Human0.91275696
185CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90453337
186ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90409340
187CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89204102
188EGR1_19032775_ChIP-ChIP_M12_Human0.87192030
189GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86014512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.95059183
2MP0000427_abnormal_hair_cycle3.44208471
3MP0000372_irregular_coat_pigmentation3.43442657
4MP0005075_abnormal_melanosome_morpholog3.24785008
5MP0000383_abnormal_hair_follicle3.12978639
6MP0010678_abnormal_skin_adnexa3.00572018
7MP0000685_abnormal_immune_system2.97370875
8MP0001986_abnormal_taste_sensitivity2.83033064
9MP0005174_abnormal_tail_pigmentation2.74824241
10MP0002095_abnormal_skin_pigmentation2.54134821
11MP0009785_altered_susceptibility_to2.52954448
12MP0005671_abnormal_response_to2.48079643
13MP0003436_decreased_susceptibility_to2.46244256
14MP0005387_immune_system_phenotype2.38378084
15MP0001790_abnormal_immune_system2.38378084
16MP0004147_increased_porphyrin_level2.37562951
17MP0005171_absent_coat_pigmentation2.31875131
18MP0001800_abnormal_humoral_immune2.30903250
19MP0002452_abnormal_antigen_presenting2.28063251
20MP0002166_altered_tumor_susceptibility2.27883292
21MP0005000_abnormal_immune_tolerance2.26303027
22MP0003303_peritoneal_inflammation2.25042372
23MP0002419_abnormal_innate_immunity2.22504669
24MP0003724_increased_susceptibility_to2.22232505
25MP0002148_abnormal_hypersensitivity_rea2.20066578
26MP0006082_CNS_inflammation2.17470550
27MP0002138_abnormal_hepatobiliary_system2.15225777
28MP0003300_gastrointestinal_ulcer2.10520419
29MP0008775_abnormal_heart_ventricle2.10295061
30MP0005025_abnormal_response_to2.09547910
31MP0002723_abnormal_immune_serum2.02753549
32MP0004484_altered_response_of2.01730318
33MP0001819_abnormal_immune_cell1.91565538
34MP0000015_abnormal_ear_pigmentation1.91395277
35MP0002420_abnormal_adaptive_immunity1.91240535
36MP0008438_abnormal_cutaneous_collagen1.88480186
37MP0002006_tumorigenesis1.83900055
38MP0005058_abnormal_lysosome_morphology1.83665403
39MP0003950_abnormal_plasma_membrane1.80917223
40MP0005464_abnormal_platelet_physiology1.77854235
41MP0005085_abnormal_gallbladder_physiolo1.76911947
42MP0004043_abnormal_pH_regulation1.72885344
43MP0003191_abnormal_cellular_cholesterol1.68503550
44MP0005397_hematopoietic_system_phenotyp1.68456080
45MP0001545_abnormal_hematopoietic_system1.68456080
46MP0001853_heart_inflammation1.66922882
47MP0000647_abnormal_sebaceous_gland1.66528822
48MP0004215_abnormal_myocardial_fiber1.64640159
49MP0010234_abnormal_vibrissa_follicle1.64387940
50MP0010155_abnormal_intestine_physiology1.64049272
51MP0004947_skin_inflammation1.63188001
52MP0004510_myositis1.61942842
53MP0002398_abnormal_bone_marrow1.54123386
54MP0002822_catalepsy1.53731713
55MP0002405_respiratory_system_inflammati1.53602436
56MP0010352_gastrointestinal_tract_polyps1.52701078
57MP0000716_abnormal_immune_system1.52549400
58MP0001873_stomach_inflammation1.50668688
59MP0001845_abnormal_inflammatory_respons1.50640318
60MP0005551_abnormal_eye_electrophysiolog1.46233383
61MP0001533_abnormal_skeleton_physiology1.46209486
62MP0002254_reproductive_system_inflammat1.42535563
63MP0008057_abnormal_DNA_replication1.41274452
64MP0000689_abnormal_spleen_morphology1.36396589
65MP0004084_abnormal_cardiac_muscle1.35714526
66MP0002396_abnormal_hematopoietic_system1.32719616
67MP0004808_abnormal_hematopoietic_stem1.32276293
68MP0009333_abnormal_splenocyte_physiolog1.32232382
69MP0003718_maternal_effect1.32078461
70MP0009840_abnormal_foam_cell1.32077802
71MP0005076_abnormal_cell_differentiation1.31204666
72MP0008469_abnormal_protein_level1.30566908
73MP0003448_altered_tumor_morphology1.27351342
74MP0002429_abnormal_blood_cell1.27310110
75MP0004885_abnormal_endolymph1.26697014
76MP0000465_gastrointestinal_hemorrhage1.25869952
77MP0003195_calcinosis1.25776000
78MP0005503_abnormal_tendon_morphology1.25002763
79MP0005253_abnormal_eye_physiology1.24931630
80MP0004381_abnormal_hair_follicle1.24820019
81MP0002722_abnormal_immune_system1.24722778
82MP0003566_abnormal_cell_adhesion1.24566334
83MP0002877_abnormal_melanocyte_morpholog1.23245354
84MP0010386_abnormal_urinary_bladder1.22394968
85MP0003705_abnormal_hypodermis_morpholog1.22378950
86MP0003136_yellow_coat_color1.20416295
87MP0002933_joint_inflammation1.20279975
88MP0009764_decreased_sensitivity_to1.18906632
89MP0003763_abnormal_thymus_physiology1.18240240
90MP0003091_abnormal_cell_migration1.15798230
91MP0000569_abnormal_digit_pigmentation1.15652330
92MP0002938_white_spotting1.15614917
93MP0001348_abnormal_lacrimal_gland1.15431288
94MP0000377_abnormal_hair_follicle1.15250343
95MP0009278_abnormal_bone_marrow1.14911302
96MP0005395_other_phenotype1.13299586
97MP0002098_abnormal_vibrissa_morphology1.12894348
98MP0010307_abnormal_tumor_latency1.12284917
99MP0002075_abnormal_coat/hair_pigmentati1.11497687
100MP0001958_emphysema1.08947317
101MP0006054_spinal_hemorrhage1.07681528
102MP0001764_abnormal_homeostasis1.06235480
103MP0003453_abnormal_keratinocyte_physiol1.06153106
104MP0005248_abnormal_Harderian_gland1.05399175
105MP0002168_other_aberrant_phenotype1.04860989
106MP0003283_abnormal_digestive_organ1.04397997
107MP0000613_abnormal_salivary_gland1.03395530
108MP0002234_abnormal_pharynx_morphology1.02880370
109MP0003567_abnormal_fetal_cardiomyocyte1.00366563
110MP0008877_abnormal_DNA_methylation1.00317490
111MP0000858_altered_metastatic_potential1.00147974
112MP0004036_abnormal_muscle_relaxation0.99135935
113MP0006072_abnormal_retinal_apoptosis0.98251343
114MP0000767_abnormal_smooth_muscle0.98145184
115MP0001879_abnormal_lymphatic_vessel0.97523967
116MP0000343_altered_response_to0.95494414
117MP0002998_abnormal_bone_remodeling0.95012414
118MP0003279_aneurysm0.94323310
119MP0003828_pulmonary_edema0.94312313
120MP0002796_impaired_skin_barrier0.93657774
121MP0005408_hypopigmentation0.93466991
122MP0008004_abnormal_stomach_pH0.93459540
123MP0003941_abnormal_skin_development0.93188258
124MP0005023_abnormal_wound_healing0.89893713
125MP0005389_reproductive_system_phenotype0.88982110
126MP0002837_dystrophic_cardiac_calcinosis0.88415765
127MP0005310_abnormal_salivary_gland0.88267150
128MP0001919_abnormal_reproductive_system0.88043644
129MP0000490_abnormal_crypts_of0.86239960
130MP0003252_abnormal_bile_duct0.85939490
131MP0002876_abnormal_thyroid_physiology0.85584402
132MP0003890_abnormal_embryonic-extraembry0.85215675
133MP0009763_increased_sensitivity_to0.85070065
134MP0000371_diluted_coat_color0.84544844
135MP0001851_eye_inflammation0.83342749
136MP0001666_abnormal_nutrient_absorption0.82704105
137MP0000538_abnormal_urinary_bladder0.81842996
138MP0001186_pigmentation_phenotype0.81516894
139MP0005390_skeleton_phenotype0.81282848
140MP0000249_abnormal_blood_vessel0.80841850
141MP0001915_intracranial_hemorrhage0.79406495
142MP0004782_abnormal_surfactant_physiolog0.78840193
143MP0009384_cardiac_valve_regurgitation0.78647235
144MP0000609_abnormal_liver_physiology0.78525285
145MP0001324_abnormal_eye_pigmentation0.78235083
146MP0003075_altered_response_to0.77782348
147MP0000703_abnormal_thymus_morphology0.77554047
148MP0005365_abnormal_bile_salt0.77296231
149MP0003045_fibrosis0.76071461
150MP0002136_abnormal_kidney_physiology0.75799760
151MP0004134_abnormal_chest_morphology0.75269569
152MP0001216_abnormal_epidermal_layer0.75055607
153MP0005275_abnormal_skin_tensile0.74515835
154MP0003806_abnormal_nucleotide_metabolis0.73319101
155MP0002009_preneoplasia0.72296656
156MP0005257_abnormal_intraocular_pressure0.71825019
157MP0005167_abnormal_blood-brain_barrier0.71235693
158MP0001661_extended_life_span0.70119419
159MP0003795_abnormal_bone_structure0.69541266
160MP0000230_abnormal_systemic_arterial0.69511855
161MP0001243_abnormal_dermal_layer0.69273815
162MP0005360_urolithiasis0.69117622
163MP0004924_abnormal_behavior0.68985006
164MP0005386_behavior/neurological_phenoty0.68985006
165MP0005595_abnormal_vascular_smooth0.68860500
166MP0002102_abnormal_ear_morphology0.68445489
167MP0005083_abnormal_biliary_tract0.68344671
168MP0005620_abnormal_muscle_contractility0.68145189
169MP0003186_abnormal_redox_activity0.68100285
170MP0001485_abnormal_pinna_reflex0.67233938
171MP0005165_increased_susceptibility_to0.65849154
172MP0003787_abnormal_imprinting0.65186516
173MP0009115_abnormal_fat_cell0.64764157
174MP0001191_abnormal_skin_condition0.62604603
175MP0001765_abnormal_ion_homeostasis0.61842368
176MP0004145_abnormal_muscle_electrophysio0.61503003
177MP0002972_abnormal_cardiac_muscle0.60850117

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.72321008
2Recurrent abscess formation (HP:0002722)4.37563778
3Recurrent bacterial skin infections (HP:0005406)4.17445097
4Hematochezia (HP:0002573)4.05419057
5Recurrent gram-negative bacterial infections (HP:0005420)3.79497737
6True hermaphroditism (HP:0010459)3.57995609
7Pancreatic cysts (HP:0001737)3.51727145
8Myocardial infarction (HP:0001658)3.50492653
9Myositis (HP:0100614)3.45331135
10Abnormality of macrophages (HP:0004311)3.35171780
11Renal cortical cysts (HP:0000803)3.33015700
12Elevated erythrocyte sedimentation rate (HP:0003565)3.30916128
13Osteolytic defects of the hand bones (HP:0009699)3.23596799
14Osteolytic defects of the phalanges of the hand (HP:0009771)3.23596799
15Generalized hypopigmentation of hair (HP:0011358)3.20062447
16Recurrent fungal infections (HP:0002841)3.17760081
17Abnormality of the renal cortex (HP:0011035)3.15861312
18Recurrent viral infections (HP:0004429)3.15611718
19Pancreatic fibrosis (HP:0100732)3.12296621
20Molar tooth sign on MRI (HP:0002419)3.12292372
21Abnormality of midbrain morphology (HP:0002418)3.12292372
22Vasculitis (HP:0002633)3.07223477
23Vacuolated lymphocytes (HP:0001922)3.07126792
24Fair hair (HP:0002286)3.04600570
25Recurrent skin infections (HP:0001581)3.03160605
26Arterial thrombosis (HP:0004420)3.03060692
27Abnormality of secondary sexual hair (HP:0009888)3.02574200
28Abnormality of the axillary hair (HP:0100134)3.02574200
29Mediastinal lymphadenopathy (HP:0100721)3.02265779
30Disinhibition (HP:0000734)2.98269330
31Thrombocytosis (HP:0001894)2.96671955
32Recurrent bronchitis (HP:0002837)2.94542377
33Periodontitis (HP:0000704)2.93462127
34Orchitis (HP:0100796)2.87060217
35Furrowed tongue (HP:0000221)2.87045219
36Conjunctival hamartoma (HP:0100780)2.85489752
37Chronic otitis media (HP:0000389)2.85371196
38Nephronophthisis (HP:0000090)2.84360428
39Chronic hepatic failure (HP:0100626)2.83054791
40Interstitial pulmonary disease (HP:0006530)2.74545892
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72420795
42Hyperventilation (HP:0002883)2.71703417
43Gastrointestinal infarctions (HP:0005244)2.70652297
44Ketoacidosis (HP:0001993)2.70145435
45Widely spaced teeth (HP:0000687)2.70134780
46Retrobulbar optic neuritis (HP:0100654)2.70004852
47Optic neuritis (HP:0100653)2.70004852
48Autoimmune thrombocytopenia (HP:0001973)2.68308169
49Decreased circulating renin level (HP:0003351)2.66665896
50Large for gestational age (HP:0001520)2.65132422
51Abnormality of the renal medulla (HP:0100957)2.64690048
52Increased cerebral lipofuscin (HP:0011813)2.63476303
53Spontaneous hematomas (HP:0007420)2.63217288
54Cellulitis (HP:0100658)2.61966780
55Abnormality of vitamin B metabolism (HP:0004340)2.61580498
56Systemic lupus erythematosus (HP:0002725)2.58685041
57Peritonitis (HP:0002586)2.56049785
58Congenital stationary night blindness (HP:0007642)2.54988803
59Abnormality of the vitamin B12 metabolism (HP:0004341)2.53193280
60Congenital sensorineural hearing impairment (HP:0008527)2.52245065
61Hamartoma of the eye (HP:0010568)2.51863611
62Abnormal biliary tract morphology (HP:0012440)2.51596113
63Abnormality of the nasal mucosa (HP:0000433)2.50875064
64Decreased central vision (HP:0007663)2.48480810
65Gingival bleeding (HP:0000225)2.48114741
66Gastrointestinal stroma tumor (HP:0100723)2.46780806
67Abnormality of T cell number (HP:0011839)2.46223009
68Abolished electroretinogram (ERG) (HP:0000550)2.43821885
69Loss of speech (HP:0002371)2.42206006
70Nasal polyposis (HP:0100582)2.41455986
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.40905535
72Vertebral compression fractures (HP:0002953)2.40797319
73Methylmalonic acidemia (HP:0002912)2.36909307
74Right ventricular cardiomyopathy (HP:0011663)2.35491139
75Esophageal varix (HP:0002040)2.35393138
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.35261248
77Aortic aneurysm (HP:0004942)2.34657916
78Medial flaring of the eyebrow (HP:0010747)2.33496698
79Inflammation of the large intestine (HP:0002037)2.33152531
80Keratoconus (HP:0000563)2.32883075
81Increased corneal curvature (HP:0100692)2.32883075
82Colitis (HP:0002583)2.32657876
83Pustule (HP:0200039)2.32219368
84Syncope (HP:0001279)2.31383841
85Glomerulonephritis (HP:0000099)2.31163699
86IgM deficiency (HP:0002850)2.30892712
87Subacute progressive viral hepatitis (HP:0006572)2.30159545
88Osteomyelitis (HP:0002754)2.29981315
89Stomatitis (HP:0010280)2.28055070
90T lymphocytopenia (HP:0005403)2.26771858
91Gastrointestinal inflammation (HP:0004386)2.24076467
92Recurrent cutaneous fungal infections (HP:0011370)2.23758536
93Chronic mucocutaneous candidiasis (HP:0002728)2.23758536
94Meningitis (HP:0001287)2.22429293
95Aortic dissection (HP:0002647)2.21843838
96Pulmonary infiltrates (HP:0002113)2.21400521
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.21210673
98Pheochromocytoma (HP:0002666)2.19624703
99Palmar hyperkeratosis (HP:0010765)2.18408543
100Emphysema (HP:0002097)2.18278613
101Metabolic alkalosis (HP:0200114)2.18170935
102Gingivitis (HP:0000230)2.17646643
103Leukocytosis (HP:0001974)2.14749825
104Blue irides (HP:0000635)2.14043808
105Chronic obstructive pulmonary disease (HP:0006510)2.13748559
106Obstructive lung disease (HP:0006536)2.13748559
107Abnormality of alanine metabolism (HP:0010916)2.11599129
108Hyperalaninemia (HP:0003348)2.11599129
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11599129
110Cone-rod dystrophy (HP:0000548)2.10843724
111Gaze-evoked nystagmus (HP:0000640)2.10125894
112Viral hepatitis (HP:0006562)2.09396148
113Abnormality of cells of the lymphoid lineage (HP:0012140)2.09002411
114Tubulointerstitial nephritis (HP:0001970)2.08196028
115Lymphopenia (HP:0001888)2.07771763
116Abnormality of T cells (HP:0002843)2.07676919
117Abnormal platelet volume (HP:0011876)2.07284785
118Alopecia of scalp (HP:0002293)2.07161496
119Attenuation of retinal blood vessels (HP:0007843)2.06343837
120Congenital, generalized hypertrichosis (HP:0004540)2.05120367
121Epistaxis (HP:0000421)2.04489564
122Abnormality of methionine metabolism (HP:0010901)2.04357587
123IgA deficiency (HP:0002720)2.04318554
124Congenital hepatic fibrosis (HP:0002612)2.03957120
125Protrusio acetabuli (HP:0003179)2.03855716
126Nephritis (HP:0000123)2.03323395
127Palpitations (HP:0001962)2.02672988
128Thyroiditis (HP:0100646)2.01742881
129Curly hair (HP:0002212)2.01391822
130Hyperactive renin-angiotensin system (HP:0000841)2.01203180
131Stomach cancer (HP:0012126)1.99962790
132Chronic diarrhea (HP:0002028)1.99647773
133Ketosis (HP:0001946)1.99310614
134Hemoptysis (HP:0002105)1.99111873
135Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98886638
136Abnormality of T cell physiology (HP:0011840)1.98615006
137Recurrent pneumonia (HP:0006532)1.98331089
138Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97815577
139Increased mean platelet volume (HP:0011877)1.96923746
140Cutaneous melanoma (HP:0012056)1.96476892
141Tachypnea (HP:0002789)1.95403445
142Gonadotropin excess (HP:0000837)1.95091443
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.93139594
144Facial diplegia (HP:0001349)1.93021315
145Autoimmune hemolytic anemia (HP:0001890)1.92685115
146Dysostosis multiplex (HP:0000943)1.92201406
147Methylmalonic aciduria (HP:0012120)1.91068931
148Neuroendocrine neoplasm (HP:0100634)1.90143083
149Premature rupture of membranes (HP:0001788)1.89867378
150Keratoconjunctivitis sicca (HP:0001097)1.89696758
151Mucosal telangiectasiae (HP:0100579)1.88656151
152Agammaglobulinemia (HP:0004432)1.88210828
153Hypoplastic labia majora (HP:0000059)1.88007923
154Tetraparesis (HP:0002273)1.87965747
155Fatigue (HP:0012378)1.87466715
156Woolly hair (HP:0002224)1.86811637
157Postaxial foot polydactyly (HP:0001830)1.86708060
158Abnormality of the lumbar spine (HP:0100712)1.86587175
159Pulmonary embolism (HP:0002204)1.86247423
160Aplasia/Hypoplasia of the fovea (HP:0008060)1.85636193
161Hypoplasia of the fovea (HP:0007750)1.85636193
162Abnormality of complement system (HP:0005339)1.85263670
163Palmoplantar hyperkeratosis (HP:0000972)1.84842829
164Hypergammaglobulinemia (HP:0010702)1.83260528
165Recurrent lower respiratory tract infections (HP:0002783)1.82893900
166Eosinophilia (HP:0001880)1.82663024
167Petechiae (HP:0000967)1.81621492
168Thyroid carcinoma (HP:0002890)1.81523057
169Macular degeneration (HP:0000608)1.81322186
170Protruding tongue (HP:0010808)1.79898000
171Biliary tract neoplasm (HP:0100574)1.79758860
172Chest pain (HP:0100749)1.79093995
173Polycythemia (HP:0001901)1.78447084
174Cystic liver disease (HP:0006706)1.77196604
175Complement deficiency (HP:0004431)1.77190089
176Plantar hyperkeratosis (HP:0007556)1.76328084
177Constricted visual fields (HP:0001133)1.75445455
178Papillary thyroid carcinoma (HP:0002895)1.74348041
179Abnormality of renin-angiotensin system (HP:0000847)1.71180076
180Portal hypertension (HP:0001409)1.70843217
181Albinism (HP:0001022)1.70265036
182Abnormality of the labia majora (HP:0012881)1.70063235
183Congenital primary aphakia (HP:0007707)1.67952027
184Erythroderma (HP:0001019)1.64074203
185Hemiparesis (HP:0001269)1.63594715
186Follicular hyperkeratosis (HP:0007502)1.62927462
187Hip dysplasia (HP:0001385)1.62500518
188Genital tract atresia (HP:0001827)1.62046812
189Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61259287
190Premature loss of primary teeth (HP:0006323)1.59609084
191Onycholysis (HP:0001806)1.59364132
192Clitoromegaly (HP:0000057)1.58057816
193Abnormal hair laboratory examination (HP:0003328)1.57956405
194Breast carcinoma (HP:0003002)1.55901453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.53407600
2BMPR1B3.15636262
3EIF2AK33.14526474
4TYK23.02916003
5ACVR1B3.01929036
6STK38L2.84904497
7MAP4K12.70495628
8TGFBR22.55948982
9TBK12.53753939
10JAK32.49524172
11BLK2.40596339
12IKBKB2.24229465
13KIT2.21459634
14STK102.12697732
15JAK12.08981125
16MAP4K22.05725544
17MKNK22.02247379
18MKNK11.90107574
19FRK1.89437180
20IKBKE1.87011834
21GRK11.81441801
22LRRK21.75934409
23CSF1R1.72122589
24FGFR31.69114562
25RIPK41.68861911
26MST1R1.68431466
27MAP3K101.64908885
28PIK3CA1.61108586
29CHUK1.61078295
30ZAP701.59997157
31PBK1.57105523
32STK391.56850460
33RPS6KA41.56554589
34MAPK131.53053615
35FGFR41.52833593
36EPHB11.52385016
37BTK1.51904477
38AKT31.51451229
39NEK91.50147719
40IRAK41.50075921
41NUAK11.49757710
42MST41.49648683
43TRIB31.47729037
44EPHA31.45647337
45PKN21.41053939
46PRKD31.40257885
47TEC1.37048573
48IRAK31.35142964
49MAPKAPK31.34978132
50CSK1.34344431
51PTK61.34126829
52FLT31.33745628
53STK31.31574362
54PIM11.26784396
55ITK1.26755355
56ERN11.21510055
57MAPKAPK51.19361305
58TRPM71.17558193
59TTN1.17367849
60TNIK1.16976478
61LCK1.14387615
62FER1.14346293
63TGFBR11.13671088
64MAP3K131.11226482
65CAMKK21.10024613
66PDK21.05251343
67JAK21.03238023
68OBSCN1.00962407
69TXK1.00332754
70ADRBK20.99857173
71CDK60.99087999
72ZAK0.98807485
73KDR0.97796980
74EEF2K0.96375097
75WNK30.95316203
76TRIM280.94762976
77PRKCE0.92930619
78PAK30.92488386
79SYK0.91735422
80STK40.91127491
81MARK30.88868895
82INSRR0.88799643
83TAF10.88193283
84LYN0.88185068
85HCK0.84595826
86MAPK70.84040676
87NEK60.83931308
88NME20.83111935
89CSNK1G20.81474275
90PRKAA20.81245682
91MAP3K40.80260912
92BMPR20.77707605
93MAP3K80.77534140
94CSNK1G10.77124283
95TAOK30.76105290
96MET0.75998125
97RIPK10.74757717
98VRK10.74392657
99OXSR10.74182753
100LATS10.70779124
101PIM20.70457290
102NLK0.70116913
103CCNB10.68083016
104MAP2K30.67759906
105ABL10.66852684
106STK240.65531771
107SCYL20.63070161
108TIE10.61183139
109SIK10.60316251
110CDK40.59789839
111EIF2AK10.58717423
112PLK20.58594658
113STK380.58463857
114CDK90.57837282
115MATK0.56632828
116MELK0.55756305
117CSNK1A1L0.55220627
118FGFR20.55079620
119BCKDK0.54507308
120EIF2AK20.53150760
121BRSK20.53082741
122YES10.52365986
123MYLK0.52077392
124BMX0.50782403
125MAPKAPK20.50426313
126MOS0.50151381
127PRKCQ0.49070648
128PIK3CG0.48543643
129PLK30.47799222
130CSNK1G30.47067025
131PAK40.46894273
132RPS6KA50.46505675
133EGFR0.45497678
134CLK10.45481975
135ERBB30.44777425
136IGF1R0.44269782
137PRKD20.40907311
138ABL20.40685120
139GSK3A0.38731021
140GRK60.38456037
141IRAK10.37971860
142BCR0.37930275
143SGK20.37269621
144WEE10.35078940
145PTK2B0.34155750
146WNK40.34142623
147MAP3K30.33932793
148INSR0.33756126
149ADRBK10.31822625
150FGR0.31381197
151HIPK20.30704003
152TNK20.30528650
153ATM0.29102102
154ERBB20.27144107
155DMPK0.25853360
156TLK10.25644424
157NEK10.23213373

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.37861850
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03734924
3Non-homologous end-joining_Homo sapiens_hsa034502.91340917
4Leishmaniasis_Homo sapiens_hsa051402.83643644
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64784912
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59261548
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.54078430
8Staphylococcus aureus infection_Homo sapiens_hsa051502.43798003
9Allograft rejection_Homo sapiens_hsa053302.36845297
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36125598
11Protein export_Homo sapiens_hsa030602.27898738
12Linoleic acid metabolism_Homo sapiens_hsa005912.25081235
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.22920942
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14095925
15Butanoate metabolism_Homo sapiens_hsa006502.09761763
16Osteoclast differentiation_Homo sapiens_hsa043802.07389369
17Legionellosis_Homo sapiens_hsa051342.07075068
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04625460
19Basal transcription factors_Homo sapiens_hsa030222.02637755
20Graft-versus-host disease_Homo sapiens_hsa053322.01955974
21Measles_Homo sapiens_hsa051622.00592413
22Malaria_Homo sapiens_hsa051442.00002454
23Antigen processing and presentation_Homo sapiens_hsa046121.99393058
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94024532
25B cell receptor signaling pathway_Homo sapiens_hsa046621.92347902
26Primary immunodeficiency_Homo sapiens_hsa053401.92075560
27Ether lipid metabolism_Homo sapiens_hsa005651.85637521
28Vitamin digestion and absorption_Homo sapiens_hsa049771.84519520
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84304770
30Toxoplasmosis_Homo sapiens_hsa051451.79890229
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79379674
32Pertussis_Homo sapiens_hsa051331.76034361
33Homologous recombination_Homo sapiens_hsa034401.74610450
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70975011
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69091746
36TNF signaling pathway_Homo sapiens_hsa046681.67934313
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65291442
38Mineral absorption_Homo sapiens_hsa049781.61387341
39Peroxisome_Homo sapiens_hsa041461.57321326
40Fatty acid elongation_Homo sapiens_hsa000621.53288708
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.51871712
42Tryptophan metabolism_Homo sapiens_hsa003801.51101267
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50577636
44Nitrogen metabolism_Homo sapiens_hsa009101.50061812
45Tuberculosis_Homo sapiens_hsa051521.49987587
46Herpes simplex infection_Homo sapiens_hsa051681.49558335
47Influenza A_Homo sapiens_hsa051641.45291043
48Shigellosis_Homo sapiens_hsa051311.45288788
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.44430931
50Apoptosis_Homo sapiens_hsa042101.43017985
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42730924
52Sphingolipid metabolism_Homo sapiens_hsa006001.40749642
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.38129038
54Fatty acid metabolism_Homo sapiens_hsa012121.35102724
55Hematopoietic cell lineage_Homo sapiens_hsa046401.34791564
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34499544
57Lysosome_Homo sapiens_hsa041421.32722461
58Viral myocarditis_Homo sapiens_hsa054161.32058244
59Complement and coagulation cascades_Homo sapiens_hsa046101.30236342
60Caffeine metabolism_Homo sapiens_hsa002321.28803404
61Hepatitis B_Homo sapiens_hsa051611.19950982
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19756403
63Salmonella infection_Homo sapiens_hsa051321.18984696
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18231511
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.18178878
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17235038
67Small cell lung cancer_Homo sapiens_hsa052221.17041563
68Fanconi anemia pathway_Homo sapiens_hsa034601.16117467
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14469960
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12937382
71Glycerolipid metabolism_Homo sapiens_hsa005611.12265930
72Circadian rhythm_Homo sapiens_hsa047101.12071050
73T cell receptor signaling pathway_Homo sapiens_hsa046601.08684970
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08013016
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07702119
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05995016
77Retinol metabolism_Homo sapiens_hsa008301.04939686
78Autoimmune thyroid disease_Homo sapiens_hsa053201.04655914
79Chemokine signaling pathway_Homo sapiens_hsa040621.04241789
80Chemical carcinogenesis_Homo sapiens_hsa052041.03856942
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03321242
82Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00953811
83Arachidonic acid metabolism_Homo sapiens_hsa005900.99075409
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95793879
85Protein digestion and absorption_Homo sapiens_hsa049740.94264684
86Dorso-ventral axis formation_Homo sapiens_hsa043200.93242479
87Hepatitis C_Homo sapiens_hsa051600.92448216
88Rheumatoid arthritis_Homo sapiens_hsa053230.92409061
89Platelet activation_Homo sapiens_hsa046110.92335084
90Asthma_Homo sapiens_hsa053100.90941678
91Viral carcinogenesis_Homo sapiens_hsa052030.90605975
92Chronic myeloid leukemia_Homo sapiens_hsa052200.89701633
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89700431
94Pancreatic cancer_Homo sapiens_hsa052120.85129444
95Amoebiasis_Homo sapiens_hsa051460.83110792
96Other glycan degradation_Homo sapiens_hsa005110.82864851
97Regulation of autophagy_Homo sapiens_hsa041400.80444361
98One carbon pool by folate_Homo sapiens_hsa006700.79679712
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79402781
100Phagosome_Homo sapiens_hsa041450.75023206
101p53 signaling pathway_Homo sapiens_hsa041150.74628352
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73990371
103Sulfur metabolism_Homo sapiens_hsa009200.72583275
104Ovarian steroidogenesis_Homo sapiens_hsa049130.72462330
105Renin secretion_Homo sapiens_hsa049240.71846336
106Acute myeloid leukemia_Homo sapiens_hsa052210.71080884
107African trypanosomiasis_Homo sapiens_hsa051430.71001402
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70657994
109Type I diabetes mellitus_Homo sapiens_hsa049400.70023386
110Epstein-Barr virus infection_Homo sapiens_hsa051690.69250453
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69081567
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.68243899
113Proteoglycans in cancer_Homo sapiens_hsa052050.67606089
114Prolactin signaling pathway_Homo sapiens_hsa049170.66518208
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.66463663
116beta-Alanine metabolism_Homo sapiens_hsa004100.66397319
117Systemic lupus erythematosus_Homo sapiens_hsa053220.66074887
118HTLV-I infection_Homo sapiens_hsa051660.65838599
119Focal adhesion_Homo sapiens_hsa045100.64785447
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64601634
121RNA degradation_Homo sapiens_hsa030180.64373700
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61178531
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60615922
124Selenocompound metabolism_Homo sapiens_hsa004500.59495223
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56929227
126Phototransduction_Homo sapiens_hsa047440.56829951
127MicroRNAs in cancer_Homo sapiens_hsa052060.56254298
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54521078
129Fatty acid biosynthesis_Homo sapiens_hsa000610.53900961
130Notch signaling pathway_Homo sapiens_hsa043300.53677780
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.52682743
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.52485666
133Nucleotide excision repair_Homo sapiens_hsa034200.51601380
134ECM-receptor interaction_Homo sapiens_hsa045120.51388394
135Insulin resistance_Homo sapiens_hsa049310.50803124
136Adherens junction_Homo sapiens_hsa045200.50572818
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.50517891
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49949004
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47760596
140Taste transduction_Homo sapiens_hsa047420.47721951
141Pyruvate metabolism_Homo sapiens_hsa006200.45308441
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44745745
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42918196
144HIF-1 signaling pathway_Homo sapiens_hsa040660.42369923
145ABC transporters_Homo sapiens_hsa020100.42241213
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40309689
147Fat digestion and absorption_Homo sapiens_hsa049750.38633433
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36824314
149Metabolic pathways_Homo sapiens_hsa011000.36329659
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36048781
151Renin-angiotensin system_Homo sapiens_hsa046140.35191020
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.33943115
153Pancreatic secretion_Homo sapiens_hsa049720.33710663
154PPAR signaling pathway_Homo sapiens_hsa033200.32770846
155Endocytosis_Homo sapiens_hsa041440.32617893
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31368328
157Prostate cancer_Homo sapiens_hsa052150.30724447
158Fatty acid degradation_Homo sapiens_hsa000710.30618120
159Steroid biosynthesis_Homo sapiens_hsa001000.30144571
160TGF-beta signaling pathway_Homo sapiens_hsa043500.28760028
161Histidine metabolism_Homo sapiens_hsa003400.27359350
162Sphingolipid signaling pathway_Homo sapiens_hsa040710.26355333
163N-Glycan biosynthesis_Homo sapiens_hsa005100.25803363
164Pentose phosphate pathway_Homo sapiens_hsa000300.25741145
165FoxO signaling pathway_Homo sapiens_hsa040680.25537766
166Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24174313
167Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23304721

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