TMEM169

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.70997203
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59591408
3nucleobase catabolic process (GO:0046113)5.40685878
4vocalization behavior (GO:0071625)5.20667302
5synaptic vesicle exocytosis (GO:0016079)5.10746650
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98850284
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89162305
8protein localization to synapse (GO:0035418)4.74039423
9neuron recognition (GO:0008038)4.56857300
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.52808551
11regulation of synaptic vesicle exocytosis (GO:2000300)4.47855796
12regulation of glutamate receptor signaling pathway (GO:1900449)4.45521581
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.37505060
14glutamate receptor signaling pathway (GO:0007215)4.36927025
15neuron-neuron synaptic transmission (GO:0007270)4.35861154
16synaptic transmission, glutamatergic (GO:0035249)4.35422149
17axonal fasciculation (GO:0007413)4.27577524
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24617236
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.19522032
20glutamate secretion (GO:0014047)4.16844620
21positive regulation of synapse maturation (GO:0090129)4.07515921
22positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.07173537
23regulation of synaptic vesicle transport (GO:1902803)3.98589463
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98555623
25synaptic vesicle maturation (GO:0016188)3.90201778
26layer formation in cerebral cortex (GO:0021819)3.88897059
27dendritic spine morphogenesis (GO:0060997)3.82672820
28neurotransmitter secretion (GO:0007269)3.80595902
29cell migration in hindbrain (GO:0021535)3.79252661
30presynaptic membrane assembly (GO:0097105)3.78879891
31central nervous system projection neuron axonogenesis (GO:0021952)3.76864232
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72485293
33transmission of nerve impulse (GO:0019226)3.71716507
34locomotory exploration behavior (GO:0035641)3.70733196
35exploration behavior (GO:0035640)3.68088498
36regulation of neuronal synaptic plasticity (GO:0048168)3.67306880
37postsynaptic membrane organization (GO:0001941)3.66785746
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64939388
39neuronal action potential propagation (GO:0019227)3.60981495
40synaptic transmission, cholinergic (GO:0007271)3.60164226
41regulation of synapse maturation (GO:0090128)3.58336057
42gamma-aminobutyric acid transport (GO:0015812)3.57293372
43auditory behavior (GO:0031223)3.57276285
44establishment of mitochondrion localization (GO:0051654)3.56315493
45synapse assembly (GO:0007416)3.56219786
46retinal ganglion cell axon guidance (GO:0031290)3.55619142
47presynaptic membrane organization (GO:0097090)3.53242720
48proline transport (GO:0015824)3.52009414
49neurofilament cytoskeleton organization (GO:0060052)3.51051285
50behavioral response to ethanol (GO:0048149)3.49266806
51dendrite morphogenesis (GO:0048813)3.47566162
52neural tube formation (GO:0001841)3.44343828
53mating behavior (GO:0007617)3.44145666
54neurotransmitter-gated ion channel clustering (GO:0072578)3.42909534
55nonmotile primary cilium assembly (GO:0035058)3.42315857
56neurotransmitter transport (GO:0006836)3.41333937
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39539359
58sequestering of actin monomers (GO:0042989)3.39457491
59regulation of synapse structural plasticity (GO:0051823)3.38269448
60behavioral fear response (GO:0001662)3.37752529
61behavioral defense response (GO:0002209)3.37752529
62synaptic vesicle endocytosis (GO:0048488)3.36708679
63cellular potassium ion homeostasis (GO:0030007)3.33099975
64long-term memory (GO:0007616)3.31812479
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31750886
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30743452
67mechanosensory behavior (GO:0007638)3.29693198
68positive regulation of synapse assembly (GO:0051965)3.27321421
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.25677758
70innervation (GO:0060384)3.25386603
71substrate-independent telencephalic tangential migration (GO:0021826)3.24868323
72substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.24868323
73regulation of neurotransmitter secretion (GO:0046928)3.23414110
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23043053
75startle response (GO:0001964)3.22374434
76regulation of postsynaptic membrane potential (GO:0060078)3.22017268
77fear response (GO:0042596)3.18490050
78regulation of vesicle fusion (GO:0031338)3.17309977
79membrane hyperpolarization (GO:0060081)3.17165657
80cerebellar Purkinje cell differentiation (GO:0021702)3.15783371
81protein polyglutamylation (GO:0018095)3.13554834
82synaptic vesicle docking involved in exocytosis (GO:0016081)3.13387525
83detection of calcium ion (GO:0005513)3.13279011
84limb bud formation (GO:0060174)3.12458959
85pyrimidine nucleobase catabolic process (GO:0006208)3.12065990
86central nervous system neuron axonogenesis (GO:0021955)3.11273040
87positive regulation of membrane potential (GO:0045838)3.08677219
88response to histamine (GO:0034776)3.08295713
89adult walking behavior (GO:0007628)3.08239939
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07269176
91mitochondrial respiratory chain complex I assembly (GO:0032981)3.07269176
92NADH dehydrogenase complex assembly (GO:0010257)3.07269176
93negative regulation of neurotransmitter transport (GO:0051589)3.05658933
94regulation of neurotransmitter levels (GO:0001505)3.05510107
95dendrite development (GO:0016358)3.05302507
96behavioral response to nicotine (GO:0035095)3.03283801
97positive regulation of mitochondrial fission (GO:0090141)3.02849737
98protein localization to cilium (GO:0061512)3.02749097
99negative regulation of dendrite development (GO:2000171)3.02663710
100regulation of dendritic spine morphogenesis (GO:0061001)3.02305360
101synapse organization (GO:0050808)2.99999995
102long-term synaptic potentiation (GO:0060291)2.99956826
103prepulse inhibition (GO:0060134)2.99633301
104gonadal mesoderm development (GO:0007506)2.99465095
105synaptic transmission (GO:0007268)2.99439442
106regulation of neurotransmitter transport (GO:0051588)2.98193861
107epithelial cilium movement (GO:0003351)2.98175872
108positive regulation of neurotransmitter secretion (GO:0001956)2.97730721
109regulation of synaptic plasticity (GO:0048167)2.95992396
110membrane depolarization during action potential (GO:0086010)2.95231750
111response to pheromone (GO:0019236)2.94567090
112righting reflex (GO:0060013)2.94354979
113membrane depolarization (GO:0051899)2.94144825
114behavioral response to cocaine (GO:0048148)2.92244186
115negative regulation of microtubule polymerization (GO:0031115)2.90602041
116regulation of respiratory system process (GO:0044065)2.89426887
117neuromuscular synaptic transmission (GO:0007274)2.89160047
118organelle transport along microtubule (GO:0072384)2.89012044
119positive regulation of potassium ion transmembrane transport (GO:1901381)2.88686790
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88023144
121positive regulation of fibroblast migration (GO:0010763)2.87736940
122olfactory bulb development (GO:0021772)2.86332444
123calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84181547
124protein complex biogenesis (GO:0070271)2.83679078
125intraciliary transport (GO:0042073)2.80666456
126short-term memory (GO:0007614)2.80129809
127response to auditory stimulus (GO:0010996)2.79518217
128cerebral cortex radially oriented cell migration (GO:0021799)2.78110161
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78003489
130somite development (GO:0061053)2.76057652
131forebrain neuron differentiation (GO:0021879)2.75662922
132head development (GO:0060322)2.74613766
133mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.74035275
134positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.74035275
135sympathetic nervous system development (GO:0048485)2.73725686
136cell proliferation in forebrain (GO:0021846)2.73072508
137negative regulation of telomere maintenance (GO:0032205)2.72367180
138neuronal action potential (GO:0019228)2.72095448
139epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71147468
140neuron fate determination (GO:0048664)2.69867969
141regulation of cilium movement (GO:0003352)2.68714355
142spinal cord association neuron differentiation (GO:0021527)2.65683366
143platelet dense granule organization (GO:0060155)2.65527352
144RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63033400
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63033400
146protein neddylation (GO:0045116)2.62417557
147hippocampus development (GO:0021766)2.61596721
148regulation of collateral sprouting (GO:0048670)2.59074683
149spinal cord development (GO:0021510)2.56217863
150glycosphingolipid biosynthetic process (GO:0006688)2.52834424
151mitochondrial respiratory chain complex assembly (GO:0033108)2.51813729
152glycerophospholipid catabolic process (GO:0046475)2.51775378
153protein-cofactor linkage (GO:0018065)2.50737609
154cornea development in camera-type eye (GO:0061303)2.49752315
155kidney morphogenesis (GO:0060993)2.49296865
156indolalkylamine metabolic process (GO:0006586)2.48680852
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47929556
158positive regulation of oligodendrocyte differentiation (GO:0048714)2.46833876
159retinal cone cell development (GO:0046549)2.45832086
160establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.45473645
161mitochondrion transport along microtubule (GO:0047497)2.45473645
162neuron migration (GO:0001764)2.44335608
163positive regulation of gastrulation (GO:2000543)2.42397829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94291877
2GBX2_23144817_ChIP-Seq_PC3_Human4.12942428
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98627779
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94127434
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79237102
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59985449
7TAF15_26573619_Chip-Seq_HEK293_Human2.56469880
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55215042
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55215042
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53813343
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.53768137
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50006407
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47422850
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46935493
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45997727
16REST_21632747_ChIP-Seq_MESCs_Mouse2.42592279
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.34643794
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28351671
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28013447
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25724850
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25439694
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14862470
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.12996811
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10235130
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09794445
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03306896
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02480006
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99828195
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.99639638
30DROSHA_22980978_ChIP-Seq_HELA_Human1.97073781
31AR_21572438_ChIP-Seq_LNCaP_Human1.92865033
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.92134319
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90832286
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88922804
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.87953768
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86498495
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83767413
38VDR_22108803_ChIP-Seq_LS180_Human1.82590318
39SMAD4_21799915_ChIP-Seq_A2780_Human1.81688565
40P300_19829295_ChIP-Seq_ESCs_Human1.77543191
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75471617
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74692286
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72230020
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.70613190
45IGF1R_20145208_ChIP-Seq_DFB_Human1.69177333
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.61669557
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.56741459
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56235213
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53649366
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52861007
51ZNF274_21170338_ChIP-Seq_K562_Hela1.51399976
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51014590
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46849588
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46544873
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.46208689
56FUS_26573619_Chip-Seq_HEK293_Human1.44990057
57RNF2_27304074_Chip-Seq_NSC_Mouse1.44987656
58AR_25329375_ChIP-Seq_VCAP_Human1.41765312
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41444968
60CBP_20019798_ChIP-Seq_JUKART_Human1.41444968
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40683202
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40591191
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39432157
64IRF1_19129219_ChIP-ChIP_H3396_Human1.38509161
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36826705
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.36476011
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36444880
68* STAT3_23295773_ChIP-Seq_U87_Human1.35684537
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35393408
70TP53_22573176_ChIP-Seq_HFKS_Human1.31427661
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30699309
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23441135
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23100892
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22196144
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21476001
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.21077276
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19728090
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.19155404
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.19065319
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18623766
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18515286
82* TCF4_23295773_ChIP-Seq_U87_Human1.18426795
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16799668
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16204271
85* RUNX2_22187159_ChIP-Seq_PCA_Human1.15958110
86ER_23166858_ChIP-Seq_MCF-7_Human1.15376485
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14942018
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14070198
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13428678
90JUN_21703547_ChIP-Seq_K562_Human1.12808824
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.12535381
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.12221545
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11207187
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10820981
95MYC_18940864_ChIP-ChIP_HL60_Human1.10275757
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10183968
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.10075668
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09931578
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09931578
100AR_19668381_ChIP-Seq_PC3_Human1.09100344
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08524749
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.07618668
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07084937
104* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05856013
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05232313
106TP53_18474530_ChIP-ChIP_U2OS_Human1.05134452
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.04542039
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03726430
109KDM2B_26808549_Chip-Seq_REH_Human1.03678660
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03304304
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03147030
112* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03071847
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.03029607
114SOX2_19829295_ChIP-Seq_ESCs_Human1.00358863
115NANOG_19829295_ChIP-Seq_ESCs_Human1.00358863
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00292608
117AHR_22903824_ChIP-Seq_MCF-7_Human0.99102748
118NCOR_22424771_ChIP-Seq_293T_Human0.98360315
119* P53_22387025_ChIP-Seq_ESCs_Mouse0.97524163
120TCF4_22108803_ChIP-Seq_LS180_Human0.97440386
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.97383218
122* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97192593
123EST1_17652178_ChIP-ChIP_JURKAT_Human0.96536887
124EWS_26573619_Chip-Seq_HEK293_Human0.96348690
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.95369039
126BCAT_22108803_ChIP-Seq_LS180_Human0.93034549
127* CMYC_18555785_Chip-Seq_ESCs_Mouse0.92704334
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.92126994
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91854133
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90825663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.12742103
2MP0004859_abnormal_synaptic_plasticity5.07012997
3MP0003635_abnormal_synaptic_transmissio3.73818617
4MP0004270_analgesia3.30267265
5MP0001968_abnormal_touch/_nociception3.14788980
6MP0009745_abnormal_behavioral_response3.04794851
7MP0002063_abnormal_learning/memory/cond3.02240706
8MP0002734_abnormal_mechanical_nocicepti2.81271683
9MP0002064_seizures2.81251798
10MP0002572_abnormal_emotion/affect_behav2.73764777
11MP0002735_abnormal_chemical_nociception2.64865380
12MP0002736_abnormal_nociception_after2.59441590
13MP0009046_muscle_twitch2.57292397
14MP0006276_abnormal_autonomic_nervous2.53680905
15MP0002272_abnormal_nervous_system2.51555781
16MP0001486_abnormal_startle_reflex2.49209503
17MP0005423_abnormal_somatic_nervous2.40390691
18MP0000778_abnormal_nervous_system2.39049383
19MP0001440_abnormal_grooming_behavior2.24237489
20MP0002653_abnormal_ependyma_morphology2.21241529
21MP0002184_abnormal_innervation2.20648206
22MP0002733_abnormal_thermal_nociception2.15609770
23MP0002067_abnormal_sensory_capabilities2.14667957
24MP0001188_hyperpigmentation2.13715457
25MP0001529_abnormal_vocalization2.03566474
26MP0001970_abnormal_pain_threshold2.00687466
27MP0001501_abnormal_sleep_pattern1.98716802
28MP0002837_dystrophic_cardiac_calcinosis1.95025096
29MP0010386_abnormal_urinary_bladder1.92379270
30MP0001984_abnormal_olfaction1.86556474
31MP0008877_abnormal_DNA_methylation1.85027487
32MP0002557_abnormal_social/conspecific_i1.80329319
33MP0002102_abnormal_ear_morphology1.80067763
34MP0004924_abnormal_behavior1.80006506
35MP0005386_behavior/neurological_phenoty1.80006506
36MP0003329_amyloid_beta_deposits1.71742154
37MP0001905_abnormal_dopamine_level1.70141265
38MP0004133_heterotaxia1.66781944
39MP0002638_abnormal_pupillary_reflex1.58174317
40MP0000955_abnormal_spinal_cord1.56971165
41MP0002822_catalepsy1.55510500
42MP0005646_abnormal_pituitary_gland1.55405513
43MP0005551_abnormal_eye_electrophysiolog1.53361822
44MP0004811_abnormal_neuron_physiology1.52074072
45MP0002882_abnormal_neuron_morphology1.49888443
46MP0003890_abnormal_embryonic-extraembry1.47345418
47MP0008995_early_reproductive_senescence1.46756897
48MP0004858_abnormal_nervous_system1.45743896
49MP0003787_abnormal_imprinting1.43020166
50MP0002938_white_spotting1.40880719
51MP0004142_abnormal_muscle_tone1.40506452
52MP0006072_abnormal_retinal_apoptosis1.39242355
53MP0001502_abnormal_circadian_rhythm1.38499427
54MP0002066_abnormal_motor_capabilities/c1.36562338
55MP0008569_lethality_at_weaning1.35546147
56MP0002234_abnormal_pharynx_morphology1.34356206
57MP0004742_abnormal_vestibular_system1.27308067
58MP0005645_abnormal_hypothalamus_physiol1.23682481
59MP0000049_abnormal_middle_ear1.21614262
60MP0002876_abnormal_thyroid_physiology1.21363736
61MP0003879_abnormal_hair_cell1.19881536
62MP0002909_abnormal_adrenal_gland1.19369018
63MP0003122_maternal_imprinting1.17957411
64MP0001986_abnormal_taste_sensitivity1.17475232
65MP0005084_abnormal_gallbladder_morpholo1.16018396
66MP0002152_abnormal_brain_morphology1.14397543
67MP0004885_abnormal_endolymph1.12294494
68MP0002752_abnormal_somatic_nervous1.10405282
69MP0004215_abnormal_myocardial_fiber1.10132886
70MP0003011_delayed_dark_adaptation1.08983531
71MP0003938_abnormal_ear_development1.07097076
72MP0000631_abnormal_neuroendocrine_gland1.03841680
73MP0005499_abnormal_olfactory_system0.99185567
74MP0005394_taste/olfaction_phenotype0.99185567
75MP0009780_abnormal_chondrocyte_physiolo0.98359977
76MP0000566_synostosis0.97895162
77MP0003136_yellow_coat_color0.96518671
78MP0003119_abnormal_digestive_system0.95124515
79MP0003633_abnormal_nervous_system0.93627959
80MP0002233_abnormal_nose_morphology0.93485341
81MP0002229_neurodegeneration0.93203637
82MP0001293_anophthalmia0.90896914
83MP0004145_abnormal_muscle_electrophysio0.89424630
84MP0002069_abnormal_eating/drinking_beha0.89374335
85MP0003631_nervous_system_phenotype0.88675963
86MP0004484_altered_response_of0.87512299
87MP0002160_abnormal_reproductive_system0.87342429
88MP0000569_abnormal_digit_pigmentation0.86949823
89MP0003646_muscle_fatigue0.86777087
90MP0001963_abnormal_hearing_physiology0.86751987
91MP0002163_abnormal_gland_morphology0.86680867
92MP0000647_abnormal_sebaceous_gland0.86331892
93MP0000372_irregular_coat_pigmentation0.84779490
94MP0005391_vision/eye_phenotype0.84390478
95MP0004043_abnormal_pH_regulation0.83815593
96MP0003937_abnormal_limbs/digits/tail_de0.83407256
97MP0001177_atelectasis0.83360391
98MP0000751_myopathy0.82495494
99MP0008874_decreased_physiological_sensi0.82074566
100MP0004085_abnormal_heartbeat0.81444778
101MP0006292_abnormal_olfactory_placode0.80672231
102MP0002928_abnormal_bile_duct0.80501706
103MP0003567_abnormal_fetal_cardiomyocyte0.79990994
104MP0008872_abnormal_physiological_respon0.79601591
105MP0003861_abnormal_nervous_system0.78470941
106MP0005535_abnormal_body_temperature0.77822413
107MP0004147_increased_porphyrin_level0.77799224
108MP0005253_abnormal_eye_physiology0.77684337
109MP0003632_abnormal_nervous_system0.73127012
110MP0003634_abnormal_glial_cell0.72089132
111MP0000026_abnormal_inner_ear0.71748858
112MP0008789_abnormal_olfactory_epithelium0.70271375
113MP0005187_abnormal_penis_morphology0.69876958
114MP0002090_abnormal_vision0.68719232
115MP0005409_darkened_coat_color0.68622942
116MP0000538_abnormal_urinary_bladder0.67321032
117MP0005195_abnormal_posterior_eye0.66462973
118MP0001664_abnormal_digestion0.63429008
119MP0002751_abnormal_autonomic_nervous0.63252543
120MP0003121_genomic_imprinting0.63038565
121MP0000604_amyloidosis0.61851037
122MP0004233_abnormal_muscle_weight0.61454034
123MP0001485_abnormal_pinna_reflex0.58276175
124MP0003137_abnormal_impulse_conducting0.56934966
125MP0010770_preweaning_lethality0.55147439
126MP0002082_postnatal_lethality0.55147439
127MP0001299_abnormal_eye_distance/0.53247226

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.41475798
2Myokymia (HP:0002411)5.46405172
3Focal seizures (HP:0007359)5.09441528
4Visual hallucinations (HP:0002367)4.94470305
5Febrile seizures (HP:0002373)4.70770904
6Epileptic encephalopathy (HP:0200134)4.48611454
7Atonic seizures (HP:0010819)4.42788754
8Progressive cerebellar ataxia (HP:0002073)4.27211543
9Absence seizures (HP:0002121)3.74478980
10Generalized tonic-clonic seizures (HP:0002069)3.67687178
11Hyperventilation (HP:0002883)3.64367841
12Dialeptic seizures (HP:0011146)3.48869241
13Pancreatic cysts (HP:0001737)3.27814408
14Broad-based gait (HP:0002136)3.24847107
15Limb dystonia (HP:0002451)3.21931955
16True hermaphroditism (HP:0010459)3.21791668
17Amblyopia (HP:0000646)3.18187933
18Molar tooth sign on MRI (HP:0002419)3.11460639
19Abnormality of midbrain morphology (HP:0002418)3.11460639
20Pancreatic fibrosis (HP:0100732)3.11411056
21Drooling (HP:0002307)3.10596147
22Excessive salivation (HP:0003781)3.10596147
23Abnormality of the labia minora (HP:0012880)3.08211794
24Action tremor (HP:0002345)3.02167646
25Insidious onset (HP:0003587)2.98927872
26Termporal pattern (HP:0011008)2.98927872
27Gaze-evoked nystagmus (HP:0000640)2.93716758
28Agitation (HP:0000713)2.90683546
29Nephronophthisis (HP:0000090)2.89459577
30Akinesia (HP:0002304)2.87708046
31Epileptiform EEG discharges (HP:0011182)2.83036668
32Truncal ataxia (HP:0002078)2.82560835
33Cerebral inclusion bodies (HP:0100314)2.77600773
34Abnormality of macular pigmentation (HP:0008002)2.77200086
35Lissencephaly (HP:0001339)2.76672615
36Supranuclear gaze palsy (HP:0000605)2.75911443
37Nephrogenic diabetes insipidus (HP:0009806)2.73448464
38EEG with generalized epileptiform discharges (HP:0011198)2.72929690
39Progressive inability to walk (HP:0002505)2.70714817
40Depression (HP:0000716)2.69988445
41Absent speech (HP:0001344)2.68936733
42Intestinal atresia (HP:0011100)2.64715002
43Pheochromocytoma (HP:0002666)2.60777552
44Anxiety (HP:0000739)2.60686686
45Fetal akinesia sequence (HP:0001989)2.60160514
46Inability to walk (HP:0002540)2.59995650
47Diplopia (HP:0000651)2.59358497
48Abnormality of binocular vision (HP:0011514)2.59358497
49Dysdiadochokinesis (HP:0002075)2.58835789
50Genetic anticipation (HP:0003743)2.55542107
51Polyphagia (HP:0002591)2.53641464
52Neurofibrillary tangles (HP:0002185)2.53427333
53Hemiparesis (HP:0001269)2.51987300
54Abnormality of the corticospinal tract (HP:0002492)2.51908119
55Pachygyria (HP:0001302)2.51445694
56Poor eye contact (HP:0000817)2.50604072
57Abnormality of the renal medulla (HP:0100957)2.47678850
58Rib fusion (HP:0000902)2.46966819
59Hypsarrhythmia (HP:0002521)2.46857369
60Chronic hepatic failure (HP:0100626)2.45874472
61Abnormal eating behavior (HP:0100738)2.45065459
62Mutism (HP:0002300)2.43946282
63Dysmetria (HP:0001310)2.43787682
64Urinary bladder sphincter dysfunction (HP:0002839)2.43438951
65Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.41700935
66Pendular nystagmus (HP:0012043)2.41461250
67Hyperalaninemia (HP:0003348)2.39463427
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39463427
69Abnormality of alanine metabolism (HP:0010916)2.39463427
70Gait imbalance (HP:0002141)2.35699328
71Severe visual impairment (HP:0001141)2.34500880
72Abnormal social behavior (HP:0012433)2.33061834
73Impaired social interactions (HP:0000735)2.33061834
74Spastic gait (HP:0002064)2.33053100
75Ankle clonus (HP:0011448)2.29961849
76Impaired vibration sensation in the lower limbs (HP:0002166)2.26558924
77Oligodactyly (hands) (HP:0001180)2.25508629
78Amyotrophic lateral sclerosis (HP:0007354)2.24174681
79Neuroendocrine neoplasm (HP:0100634)2.23500102
80Acute necrotizing encephalopathy (HP:0006965)2.22795401
81Sclerocornea (HP:0000647)2.22603621
82Thyroid-stimulating hormone excess (HP:0002925)2.19214341
83Anencephaly (HP:0002323)2.18959042
84Hyperglycinemia (HP:0002154)2.17866887
85Retinal dysplasia (HP:0007973)2.16793626
86Cortical dysplasia (HP:0002539)2.16213205
87Abolished electroretinogram (ERG) (HP:0000550)2.16091968
88Anophthalmia (HP:0000528)2.15571730
89Peripheral hypomyelination (HP:0007182)2.14672163
90Type II lissencephaly (HP:0007260)2.13625815
91Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12912014
92Hypoplasia of the brainstem (HP:0002365)2.12912014
93Horizontal nystagmus (HP:0000666)2.12512300
94Exotropia (HP:0000577)2.12481917
95Generalized myoclonic seizures (HP:0002123)2.11016652
96Abnormality of salivation (HP:0100755)2.10938336
97Bradykinesia (HP:0002067)2.10484694
98Scanning speech (HP:0002168)2.09306621
99Incomplete penetrance (HP:0003829)2.07977791
100Optic nerve hypoplasia (HP:0000609)2.05763112
101Hypothermia (HP:0002045)2.05719711
102Postaxial hand polydactyly (HP:0001162)2.03729643
103Urinary urgency (HP:0000012)2.03422452
104Central scotoma (HP:0000603)2.02484486
105Abnormality of the renal cortex (HP:0011035)2.00697833
106Growth hormone deficiency (HP:0000824)2.00690086
107Genital tract atresia (HP:0001827)1.99490660
108Cystic liver disease (HP:0006706)1.98824567
109Protruding tongue (HP:0010808)1.98040115
110Poor suck (HP:0002033)1.97819729
111Mitochondrial inheritance (HP:0001427)1.97240733
112Esotropia (HP:0000565)1.96867892
113Poor coordination (HP:0002370)1.96187750
114Acute encephalopathy (HP:0006846)1.95700467
115Split foot (HP:0001839)1.95287438
116Impaired smooth pursuit (HP:0007772)1.95238265
117Congenital stationary night blindness (HP:0007642)1.94984104
118Progressive macrocephaly (HP:0004481)1.93529200
119Narrow forehead (HP:0000341)1.92858118
120Vaginal atresia (HP:0000148)1.92066283
121Hepatoblastoma (HP:0002884)1.90677625
122Delusions (HP:0000746)1.90667350
123Stereotypic behavior (HP:0000733)1.88901382
124Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88831234
125Cholecystitis (HP:0001082)1.88727787
126Abnormal gallbladder physiology (HP:0012438)1.88727787
127Disproportionate short-trunk short stature (HP:0003521)1.85954814
128Lower limb muscle weakness (HP:0007340)1.85261739
129Oligodactyly (HP:0012165)1.85042749
130Failure to thrive in infancy (HP:0001531)1.84650824
131Status epilepticus (HP:0002133)1.84439001
132Methylmalonic acidemia (HP:0002912)1.83201843
133Specific learning disability (HP:0001328)1.83154248
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.83126021
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83126021
136Medial flaring of the eyebrow (HP:0010747)1.83029748
137Abnormal mitochondria in muscle tissue (HP:0008316)1.82598892
138Postural instability (HP:0002172)1.82482696
1393-Methylglutaconic aciduria (HP:0003535)1.82289733
140Spastic tetraplegia (HP:0002510)1.81729258
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81343267
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.80927449
143Congenital primary aphakia (HP:0007707)1.80321728
144Inappropriate behavior (HP:0000719)1.79534663
145Focal dystonia (HP:0004373)1.79340789
146Increased CSF lactate (HP:0002490)1.79308802
147Occipital encephalocele (HP:0002085)1.79019339
148Abnormal rod and cone electroretinograms (HP:0008323)1.78069903
149Septo-optic dysplasia (HP:0100842)1.77984183
150Attenuation of retinal blood vessels (HP:0007843)1.75655994
151Patellar aplasia (HP:0006443)1.75651597
152Postaxial foot polydactyly (HP:0001830)1.75490392
153Absent eyebrow (HP:0002223)1.75351867
154Colon cancer (HP:0003003)1.75310428
155Widely spaced teeth (HP:0000687)1.74918969
156Blue irides (HP:0000635)1.74778026
157Abnormality of ocular smooth pursuit (HP:0000617)1.74558422
158Labial hypoplasia (HP:0000066)1.74165159
159Bony spicule pigmentary retinopathy (HP:0007737)1.73470051
160Renal cortical cysts (HP:0000803)1.73189013
161Chorioretinal atrophy (HP:0000533)1.71196802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.40389997
2MARK14.22433065
3EPHA44.10278437
4MAP3K43.79945516
5MAP2K73.46006600
6CASK2.89649770
7MAP3K92.88266418
8TRIM282.71972128
9FRK2.51397810
10MINK12.41536977
11PNCK2.36497556
12MAP4K22.28892703
13MAP2K42.12464257
14KSR11.90338057
15PAK61.86379544
16MAP3K121.84841773
17NTRK21.81928286
18MAP3K61.74158485
19PLK21.73634102
20KSR21.72969670
21MAPK131.63005935
22GRK51.53170818
23RIPK41.51088523
24DYRK31.49444611
25FES1.47728438
26NTRK11.47724083
27EPHA31.47380884
28LATS21.47156495
29INSRR1.41378305
30DAPK21.41256678
31TNIK1.37884707
32GRK11.34065174
33CDK51.28144423
34SIK21.24872573
35CAMK2A1.24191846
36PRKCG1.18411671
37EPHB21.15659379
38WNK31.14143110
39OXSR11.13625017
40STK161.11828209
41DYRK21.08950154
42SGK2231.07444927
43SGK4941.07444927
44PRPF4B1.06193403
45NUAK11.05953685
46CAMK2B1.04990938
47CSNK1G21.04249542
48DYRK1B1.03424934
49BMPR20.98637571
50CDK190.97930050
51PAK30.97019733
52PHKG10.96042861
53PHKG20.96042861
54TAOK30.95535704
55MKNK20.93874806
56STK380.90838000
57NME10.90787928
58FER0.90554007
59DYRK1A0.89557061
60RET0.88942285
61UHMK10.88890591
62DAPK10.85569753
63SRPK10.85262109
64MAP3K20.85123466
65CDK140.84687058
66CAMKK10.83984393
67PTK2B0.83851178
68ACVR1B0.83460630
69CDK180.82124258
70ARAF0.81762793
71PRKCE0.81513066
72AKT30.80487319
73CAMK2D0.80317581
74CDK150.79598903
75BCKDK0.78788300
76SGK20.78684614
77FGFR20.77771311
78FGR0.75800941
79MKNK10.75351004
80STK390.75221712
81CSNK1G30.74649154
82PIK3CA0.74305396
83VRK10.73543718
84WNK40.71093919
85ADRBK20.70805999
86TLK10.69717251
87BCR0.69575847
88BRAF0.68901435
89ZAK0.68347979
90CDK11A0.67146544
91ERBB40.67091236
92SIK30.66035971
93STK110.62658215
94ERBB30.62439715
95SGK10.59978649
96CSNK1A10.57741772
97MUSK0.57483965
98RPS6KA40.56842417
99RAF10.55019474
100MAP2K10.51129824
101CAMK2G0.50436204
102MARK20.50393881
103BMPR1B0.48479636
104ADRBK10.48143000
105PRKCZ0.46897710
106PKN10.45903473
107STK38L0.45664606
108CSNK1D0.45292658
109ROCK20.44333620
110CAMKK20.44329294
111CAMK1G0.42660904
112PLK30.42630510
113GRK70.42397995
114CAMK40.41143719
115CAMK10.39190033
116PRKACA0.38441318
117TNK20.38298075
118MAPKAPK50.37997822
119CSNK1G10.37472453
120CSNK1A1L0.37028084
121PINK10.36823489
122TYRO30.36700797
123PRKAA10.36599846
124PRKG10.35879454
125MAPK100.34663075
126ERBB20.34642597
127RPS6KA50.33878316
128RPS6KA20.33175900
129RPS6KA30.32050052
130LIMK10.31970663
131SGK30.31791530
132CSNK1E0.31668458
133CDK80.31652859
134PRKACB0.30156638
135CDK30.27744089
136PRKCA0.27691026

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.32281128
2Synaptic vesicle cycle_Homo sapiens_hsa047213.47654330
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90076791
4GABAergic synapse_Homo sapiens_hsa047272.74000727
5Morphine addiction_Homo sapiens_hsa050322.65078748
6Glutamatergic synapse_Homo sapiens_hsa047242.56626381
7Circadian entrainment_Homo sapiens_hsa047132.50736288
8Long-term potentiation_Homo sapiens_hsa047202.46150302
9Taste transduction_Homo sapiens_hsa047422.32569337
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26374238
11Dopaminergic synapse_Homo sapiens_hsa047282.24371254
12Amphetamine addiction_Homo sapiens_hsa050312.22627171
13Serotonergic synapse_Homo sapiens_hsa047262.21032609
14Collecting duct acid secretion_Homo sapiens_hsa049662.18087224
15Olfactory transduction_Homo sapiens_hsa047402.17326295
16Protein export_Homo sapiens_hsa030602.15481772
17Insulin secretion_Homo sapiens_hsa049111.98622561
18Cholinergic synapse_Homo sapiens_hsa047251.93670484
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92064153
20Long-term depression_Homo sapiens_hsa047301.91842147
21Salivary secretion_Homo sapiens_hsa049701.81931168
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75031348
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.69151274
24Cocaine addiction_Homo sapiens_hsa050301.65622864
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.65577826
26Renin secretion_Homo sapiens_hsa049241.63066802
27Linoleic acid metabolism_Homo sapiens_hsa005911.56728216
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54700146
29Calcium signaling pathway_Homo sapiens_hsa040201.51456158
30Steroid biosynthesis_Homo sapiens_hsa001001.49941109
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47738432
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47353937
33Axon guidance_Homo sapiens_hsa043601.41828090
34Gastric acid secretion_Homo sapiens_hsa049711.41175348
35Oxytocin signaling pathway_Homo sapiens_hsa049211.40784354
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40614421
37Basal transcription factors_Homo sapiens_hsa030221.39720937
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39021169
39Gap junction_Homo sapiens_hsa045401.35526705
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34032864
41Ether lipid metabolism_Homo sapiens_hsa005651.31576333
42Nitrogen metabolism_Homo sapiens_hsa009101.29771462
43Propanoate metabolism_Homo sapiens_hsa006401.28882674
44GnRH signaling pathway_Homo sapiens_hsa049121.28485127
45Cardiac muscle contraction_Homo sapiens_hsa042601.27763136
46Vibrio cholerae infection_Homo sapiens_hsa051101.22777510
47Oxidative phosphorylation_Homo sapiens_hsa001901.20363735
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18509891
49cAMP signaling pathway_Homo sapiens_hsa040241.17726854
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17632911
51Caffeine metabolism_Homo sapiens_hsa002321.17631285
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15955686
53Type II diabetes mellitus_Homo sapiens_hsa049301.14906111
54Regulation of autophagy_Homo sapiens_hsa041401.14644022
55RNA degradation_Homo sapiens_hsa030181.14363562
56Fanconi anemia pathway_Homo sapiens_hsa034601.12040684
57Phototransduction_Homo sapiens_hsa047441.12012979
58Peroxisome_Homo sapiens_hsa041461.10821420
59Tryptophan metabolism_Homo sapiens_hsa003801.07396665
60Selenocompound metabolism_Homo sapiens_hsa004501.07044211
61Alzheimers disease_Homo sapiens_hsa050101.04961375
62Estrogen signaling pathway_Homo sapiens_hsa049151.04164353
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04008326
64ErbB signaling pathway_Homo sapiens_hsa040121.03777363
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98047663
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.97796703
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97274379
68Dorso-ventral axis formation_Homo sapiens_hsa043200.91712568
69Melanogenesis_Homo sapiens_hsa049160.90340914
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90006730
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87097264
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86971771
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86309728
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85627143
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.84931474
76Choline metabolism in cancer_Homo sapiens_hsa052310.84251877
77Glioma_Homo sapiens_hsa052140.83201826
78Parkinsons disease_Homo sapiens_hsa050120.83012264
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82511910
80Oocyte meiosis_Homo sapiens_hsa041140.80537394
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80110092
82RNA polymerase_Homo sapiens_hsa030200.74485813
83Basal cell carcinoma_Homo sapiens_hsa052170.69123488
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66183171
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.64898635
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64684930
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64630021
88Retinol metabolism_Homo sapiens_hsa008300.61944171
89MAPK signaling pathway_Homo sapiens_hsa040100.61585498
90Pancreatic secretion_Homo sapiens_hsa049720.61387527
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61024615
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.60497824
93Colorectal cancer_Homo sapiens_hsa052100.59661203
94Metabolic pathways_Homo sapiens_hsa011000.59571221
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58476584
96Fat digestion and absorption_Homo sapiens_hsa049750.57190066
97Ras signaling pathway_Homo sapiens_hsa040140.56778590
98Huntingtons disease_Homo sapiens_hsa050160.55666655
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55023295
100Circadian rhythm_Homo sapiens_hsa047100.54757004
101Thyroid hormone synthesis_Homo sapiens_hsa049180.54706858
102Butanoate metabolism_Homo sapiens_hsa006500.54570366
103Hippo signaling pathway_Homo sapiens_hsa043900.54490079
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54235901
105beta-Alanine metabolism_Homo sapiens_hsa004100.53991564
106Dilated cardiomyopathy_Homo sapiens_hsa054140.53946186
107Alcoholism_Homo sapiens_hsa050340.53064641
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52622760
109Chemical carcinogenesis_Homo sapiens_hsa052040.52268214
110Ovarian steroidogenesis_Homo sapiens_hsa049130.52194292
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51512693
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49559256
113Endometrial cancer_Homo sapiens_hsa052130.49128159
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48200470
115Renal cell carcinoma_Homo sapiens_hsa052110.46222766
116Fatty acid elongation_Homo sapiens_hsa000620.45222529
117Wnt signaling pathway_Homo sapiens_hsa043100.44794434
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.42200132
119Rheumatoid arthritis_Homo sapiens_hsa053230.40955511
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40616384
121Phagosome_Homo sapiens_hsa041450.38421918
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37980511
123Glucagon signaling pathway_Homo sapiens_hsa049220.37348303
124Rap1 signaling pathway_Homo sapiens_hsa040150.37167161
125Fatty acid metabolism_Homo sapiens_hsa012120.37044327
126One carbon pool by folate_Homo sapiens_hsa006700.35851983
127Sulfur relay system_Homo sapiens_hsa041220.35481254
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.35358463
129Inositol phosphate metabolism_Homo sapiens_hsa005620.35217703
130Hedgehog signaling pathway_Homo sapiens_hsa043400.34865525
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34589683
132VEGF signaling pathway_Homo sapiens_hsa043700.34078314
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32310973
134Arachidonic acid metabolism_Homo sapiens_hsa005900.31833888
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31200819
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.30776318
137Sulfur metabolism_Homo sapiens_hsa009200.30445251
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30405026
139Homologous recombination_Homo sapiens_hsa034400.30200952
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28770438
141Insulin signaling pathway_Homo sapiens_hsa049100.28710135
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28499810
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28298634
144Arginine and proline metabolism_Homo sapiens_hsa003300.28212543
145mTOR signaling pathway_Homo sapiens_hsa041500.27921215
146Type I diabetes mellitus_Homo sapiens_hsa049400.26731525
147Bile secretion_Homo sapiens_hsa049760.26662604
148African trypanosomiasis_Homo sapiens_hsa051430.25253636

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