ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fucose catabolic process (GO:0019317)	4.26659318
2	L-fucose metabolic process (GO:0042354)	4.26659318
3	L-fucose catabolic process (GO:0042355)	4.26659318
4	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.16808873
5	replication fork processing (GO:0031297)	4.13887035
6	DNA double-strand break processing (GO:0000729)	4.09779705
7	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.08038184
8	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.08038184
9	chromatin remodeling at centromere (GO:0031055)	3.46275205
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.41674914
11	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.39002749
12	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.39002749
13	regulation of translation, ncRNA-mediated (GO:0045974)	3.39002749
14	DNA deamination (GO:0045006)	3.38322135
15	behavioral response to nicotine (GO:0035095)	3.36326238
16	kidney morphogenesis (GO:0060993)	3.33778933
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.30973317
18	recombinational repair (GO:0000725)	3.26485886
19	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.24239945
20	CENP-A containing nucleosome assembly (GO:0034080)	3.23977562
21	double-strand break repair via homologous recombination (GO:0000724)	3.23340182
22	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.22209894
23	respiratory chain complex IV assembly (GO:0008535)	3.19886575
24	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.18295854
25	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.18295854
26	isotype switching (GO:0045190)	3.18295854
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.11824116
28	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.11593378
29	neural tube formation (GO:0001841)	3.10371901
30	resolution of meiotic recombination intermediates (GO:0000712)	3.07974468
31	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.07581776
32	regulation of mitotic spindle checkpoint (GO:1903504)	3.07581776
33	centriole replication (GO:0007099)	3.07457645
34	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.05586215
35	presynaptic membrane assembly (GO:0097105)	3.05324672
36	regulation of meiosis I (GO:0060631)	3.05062854
37	synapsis (GO:0007129)	2.99231496
38	protein-cofactor linkage (GO:0018065)	2.98590938
39	regulation of DNA endoreduplication (GO:0032875)	2.97524837
40	somatic diversification of immunoglobulins (GO:0016445)	2.96464324
41	histone exchange (GO:0043486)	2.96160292
42	response to pheromone (GO:0019236)	2.96123116
43	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.94238526
44	neuron fate determination (GO:0048664)	2.90766754
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.86824832
46	regulation of mesoderm development (GO:2000380)	2.83957068
47	limb bud formation (GO:0060174)	2.82970828
48	negative regulation of DNA recombination (GO:0045910)	2.78289878
49	DNA catabolic process, exonucleolytic (GO:0000738)	2.74113609
50	proteasome assembly (GO:0043248)	2.73711985
51	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.73465569
52	protein neddylation (GO:0045116)	2.71912623
53	cytochrome complex assembly (GO:0017004)	2.62494544
54	somite rostral/caudal axis specification (GO:0032525)	2.61654835
55	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.61640705
56	reciprocal meiotic recombination (GO:0007131)	2.61535963
57	reciprocal DNA recombination (GO:0035825)	2.61535963
58	intra-S DNA damage checkpoint (GO:0031573)	2.58344236
59	nonmotile primary cilium assembly (GO:0035058)	2.57745184
60	protein K6-linked ubiquitination (GO:0085020)	2.57598014
61	protein K11-linked deubiquitination (GO:0035871)	2.56754426
62	somatic diversification of immune receptors (GO:0002200)	2.56157443
63	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.55996956
64	DNA replication-dependent nucleosome organization (GO:0034723)	2.55810749
65	DNA replication-dependent nucleosome assembly (GO:0006335)	2.55810749
66	DNA replication checkpoint (GO:0000076)	2.54978412
67	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.53995253
68	dorsal/ventral axis specification (GO:0009950)	2.53826911
69	presynaptic membrane organization (GO:0097090)	2.53561290
70	signal peptide processing (GO:0006465)	2.51199121
71	cilium morphogenesis (GO:0060271)	2.50065113
72	photoreceptor cell maintenance (GO:0045494)	2.49481320
73	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.49000526
74	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.49000526
75	meiotic chromosome segregation (GO:0045132)	2.48397603
76	epithelial cilium movement (GO:0003351)	2.48092864
77	histone mRNA metabolic process (GO:0008334)	2.47611034
78	postreplication repair (GO:0006301)	2.45131122
79	sulfation (GO:0051923)	2.44332690
80	regulation of timing of cell differentiation (GO:0048505)	2.43251434
81	mitotic sister chromatid cohesion (GO:0007064)	2.43163862
82	platelet dense granule organization (GO:0060155)	2.42965611
83	regulation of gene silencing by RNA (GO:0060966)	2.42690779
84	regulation of posttranscriptional gene silencing (GO:0060147)	2.42690779
85	regulation of gene silencing by miRNA (GO:0060964)	2.42690779
86	nucleobase biosynthetic process (GO:0046112)	2.42435735
87	axoneme assembly (GO:0035082)	2.42362238
88	pseudouridine synthesis (GO:0001522)	2.41296911
89	otic vesicle formation (GO:0030916)	2.41073894
90	ncRNA catabolic process (GO:0034661)	2.40751010
91	intraciliary transport (GO:0042073)	2.40431037
92	protein prenylation (GO:0018342)	2.40249752
93	prenylation (GO:0097354)	2.40249752
94	somite development (GO:0061053)	2.39591753
95	piRNA metabolic process (GO:0034587)	2.39410034
96	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.38860646
97	regulation of telomere maintenance (GO:0032204)	2.38815498
98	regulation of development, heterochronic (GO:0040034)	2.38533269
99	activated T cell proliferation (GO:0050798)	2.37488577
100	regulation of centriole replication (GO:0046599)	2.37262133

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.37738642
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.32928185
3	VDR_22108803_ChIP-Seq_LS180_Human	2.96736300
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.83374963
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60336143
6	EWS_26573619_Chip-Seq_HEK293_Human	2.51919624
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.48839004
8	FUS_26573619_Chip-Seq_HEK293_Human	2.47426274
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.43201771
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.42185952
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.39575887
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38854155
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.28706390
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.26385561
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25038016
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.22789630
17	P300_19829295_ChIP-Seq_ESCs_Human	2.20802637
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.15125484
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.14742929
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.12858408
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.09993808
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.04142219
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.02702904
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.98202635
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96679349
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89513377
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86807369
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83785649
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.83391515
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72719119
31	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.66880393
32	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.60242241
33	* VDR_23849224_ChIP-Seq_CD4+_Human	1.58991003
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58707488
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.52631755
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49413136
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.46424809
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43193945
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43022559
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.39555873
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38295913
42	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36766674
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36506262
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36506262
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.36319096
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35541948
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35330828
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.35172589
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34800185
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34756181
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34542208
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.34050039
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34050039
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.33758098
55	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.33694228
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32748128
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31311348
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31029784
59	E2F7_22180533_ChIP-Seq_HELA_Human	1.30382392
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30362816
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30217042
62	STAT3_23295773_ChIP-Seq_U87_Human	1.29500272
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27717021
64	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.27131067
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.25738053
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24260237
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.23878486
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22996235
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22996235
70	FOXP3_21729870_ChIP-Seq_TREG_Human	1.22283437
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21003992
72	AR_25329375_ChIP-Seq_VCAP_Human	1.16565641
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16089698
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16089698
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13753162
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13129401
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12107583
78	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11400723
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10554360
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09864721
81	TCF4_23295773_ChIP-Seq_U87_Human	1.09845311
82	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.09719012
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08930532
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08314404
85	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.07207388
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05676082
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.03011898
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01724377
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00460655
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00306189
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99606737
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98235392
93	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.97845061
94	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.96673043
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96650179
96	P300_18555785_Chip-Seq_ESCs_Mouse	0.94616258
97	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.93528246
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93337619
99	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.93095726
100	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.91916082

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.73777184
2	MP0000569_abnormal_digit_pigmentation	3.60751793
3	MP0003136_yellow_coat_color	2.83694090
4	MP0003890_abnormal_embryonic-extraembry	2.79157422
5	MP0004147_increased_porphyrin_level	2.62726771
6	MP0008058_abnormal_DNA_repair	2.60299334
7	MP0003195_calcinosis	2.51190157
8	MP0008057_abnormal_DNA_replication	2.44340947
9	MP0010094_abnormal_chromosome_stability	2.29775593
10	MP0006292_abnormal_olfactory_placode	2.29418230
11	MP0003787_abnormal_imprinting	2.27780474
12	MP0002254_reproductive_system_inflammat	2.22272540
13	MP0002938_white_spotting	2.19491050
14	MP0002102_abnormal_ear_morphology	2.03408974
15	MP0005084_abnormal_gallbladder_morpholo	1.98558282
16	MP0002638_abnormal_pupillary_reflex	1.94613685
17	MP0005174_abnormal_tail_pigmentation	1.93131656
18	MP0006072_abnormal_retinal_apoptosis	1.92133648
19	MP0003121_genomic_imprinting	1.89339668
20	MP0002736_abnormal_nociception_after	1.86368162
21	MP0002653_abnormal_ependyma_morphology	1.86263816
22	MP0001293_anophthalmia	1.84616097
23	MP0003567_abnormal_fetal_cardiomyocyte	1.82880380
24	MP0001485_abnormal_pinna_reflex	1.74407425
25	MP0003693_abnormal_embryo_hatching	1.71036897
26	MP0005551_abnormal_eye_electrophysiolog	1.65855288
27	MP0001529_abnormal_vocalization	1.59382755
28	MP0003122_maternal_imprinting	1.59046383
29	MP0004133_heterotaxia	1.54631571
30	MP0004885_abnormal_endolymph	1.51812490
31	MP0005253_abnormal_eye_physiology	1.47256734
32	MP0001968_abnormal_touch/_nociception	1.44171180
33	MP0002928_abnormal_bile_duct	1.44055108
34	MP0000631_abnormal_neuroendocrine_gland	1.43129630
35	MP0008872_abnormal_physiological_respon	1.42701229
36	MP0001984_abnormal_olfaction	1.37564769
37	MP0004957_abnormal_blastocyst_morpholog	1.34221707
38	MP0003937_abnormal_limbs/digits/tail_de	1.33431417
39	MP0003718_maternal_effect	1.32660172
40	MP0002277_abnormal_respiratory_mucosa	1.28352457
41	MP0000516_abnormal_urinary_system	1.25047885
42	MP0005367_renal/urinary_system_phenotyp	1.25047885
43	MP0000383_abnormal_hair_follicle	1.24357910
44	MP0000427_abnormal_hair_cycle	1.20865822
45	MP0001286_abnormal_eye_development	1.15677534
46	MP0002095_abnormal_skin_pigmentation	1.13766181
47	MP0000372_irregular_coat_pigmentation	1.13684531
48	MP0001486_abnormal_startle_reflex	1.11674262
49	MP0005645_abnormal_hypothalamus_physiol	1.10154785
50	MP0005075_abnormal_melanosome_morpholog	1.10141158
51	MP0002751_abnormal_autonomic_nervous	1.08505877
52	MP0008995_early_reproductive_senescence	1.07523426
53	MP0001188_hyperpigmentation	1.05284396
54	MP0001929_abnormal_gametogenesis	1.04915730
55	MP0004142_abnormal_muscle_tone	1.03777023
56	MP0003111_abnormal_nucleus_morphology	1.02854074
57	MP0003119_abnormal_digestive_system	0.99557044
58	MP0003077_abnormal_cell_cycle	0.98220853
59	MP0000647_abnormal_sebaceous_gland	0.96703997
60	MP0001324_abnormal_eye_pigmentation	0.96395563
61	MP0003880_abnormal_central_pattern	0.96312971
62	MP0002210_abnormal_sex_determination	0.95737900
63	MP0000778_abnormal_nervous_system	0.95236438
64	MP0005195_abnormal_posterior_eye	0.93217141
65	MP0003011_delayed_dark_adaptation	0.91920759
66	MP0001145_abnormal_male_reproductive	0.91670685
67	MP0004742_abnormal_vestibular_system	0.91336392
68	MP0009745_abnormal_behavioral_response	0.91275997
69	MP0000653_abnormal_sex_gland	0.90406087
70	MP0003943_abnormal_hepatobiliary_system	0.87754752
71	MP0003786_premature_aging	0.87187091
72	MP0005391_vision/eye_phenotype	0.86999562
73	MP0010678_abnormal_skin_adnexa	0.86646266
74	MP0008007_abnormal_cellular_replicative	0.85462066
75	MP0001501_abnormal_sleep_pattern	0.84962838
76	MP0003283_abnormal_digestive_organ	0.83292252
77	MP0005379_endocrine/exocrine_gland_phen	0.79818412
78	MP0002272_abnormal_nervous_system	0.79795231
79	MP0003698_abnormal_male_reproductive	0.79774638
80	MP0005377_hearing/vestibular/ear_phenot	0.79260096
81	MP0003878_abnormal_ear_physiology	0.79260096
82	MP0001119_abnormal_female_reproductive	0.78758398
83	MP0002233_abnormal_nose_morphology	0.77932949
84	MP0009046_muscle_twitch	0.77317733
85	MP0002090_abnormal_vision	0.77034896
86	MP0001986_abnormal_taste_sensitivity	0.76332952
87	MP0008875_abnormal_xenobiotic_pharmacok	0.75857614
88	MP0002163_abnormal_gland_morphology	0.75809113
89	MP0002067_abnormal_sensory_capabilities	0.75178781
90	MP0009697_abnormal_copulation	0.73167472
91	MP0005085_abnormal_gallbladder_physiolo	0.70482531
92	MP0001919_abnormal_reproductive_system	0.70030866
93	MP0002837_dystrophic_cardiac_calcinosis	0.69418153
94	MP0002111_abnormal_tail_morphology	0.68807207
95	MP0006035_abnormal_mitochondrial_morpho	0.67733024
96	MP0005646_abnormal_pituitary_gland	0.67670751
97	MP0002557_abnormal_social/conspecific_i	0.65961343
98	MP0008932_abnormal_embryonic_tissue	0.65092856
99	MP0004019_abnormal_vitamin_homeostasis	0.64321917
100	MP0003936_abnormal_reproductive_system	0.63705786

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.62666324
2	Abnormality of midbrain morphology (HP:0002418)	3.36509994
3	Molar tooth sign on MRI (HP:0002419)	3.36509994
4	True hermaphroditism (HP:0010459)	3.35625732
5	Pancreatic fibrosis (HP:0100732)	3.33307826
6	Abnormality of the labia minora (HP:0012880)	3.01183794
7	Nephronophthisis (HP:0000090)	2.90970139
8	Congenital stationary night blindness (HP:0007642)	2.76761412
9	Abnormality of the pons (HP:0007361)	2.69410926
10	Abnormality of the renal medulla (HP:0100957)	2.64237629
11	Colon cancer (HP:0003003)	2.62231397
12	Abnormality of the renal cortex (HP:0011035)	2.61268538
13	Hypoplasia of the pons (HP:0012110)	2.60294451
14	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.48929776
15	Meckel diverticulum (HP:0002245)	2.48315747
16	Oligodactyly (hands) (HP:0001180)	2.45957532
17	Abnormality of chromosome stability (HP:0003220)	2.43040849
18	Abnormality of the ileum (HP:0001549)	2.42040122
19	Septo-optic dysplasia (HP:0100842)	2.39846214
20	Medial flaring of the eyebrow (HP:0010747)	2.39029969
21	Volvulus (HP:0002580)	2.33416589
22	Chronic hepatic failure (HP:0100626)	2.32392775
23	Methylmalonic acidemia (HP:0002912)	2.28354825
24	Tubular atrophy (HP:0000092)	2.26120638
25	Intestinal atresia (HP:0011100)	2.24643381
26	Abolished electroretinogram (ERG) (HP:0000550)	2.15223134
27	Hyperglycinuria (HP:0003108)	2.08664872
28	Hyperglycinemia (HP:0002154)	2.07803386
29	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.06039759
30	Abnormal biliary tract physiology (HP:0012439)	2.05930097
31	Bile duct proliferation (HP:0001408)	2.05930097
32	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.04095357
33	Asplenia (HP:0001746)	2.03668799
34	Hyperventilation (HP:0002883)	2.02799875
35	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01142103
36	Sclerocornea (HP:0000647)	2.00762334
37	Anophthalmia (HP:0000528)	1.97853086
38	Genital tract atresia (HP:0001827)	1.97639353
39	Progressive inability to walk (HP:0002505)	1.97550912
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.96129988
41	Chromsome breakage (HP:0040012)	1.95786080
42	Optic nerve hypoplasia (HP:0000609)	1.95190425
43	Stomach cancer (HP:0012126)	1.88301003
44	Type II lissencephaly (HP:0007260)	1.88185438
45	Vaginal atresia (HP:0000148)	1.88024947
46	Hypoplasia of the fovea (HP:0007750)	1.87505283
47	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.87505283
48	Gastrointestinal atresia (HP:0002589)	1.87454045
49	Postaxial foot polydactyly (HP:0001830)	1.86606413
50	Rhabdomyosarcoma (HP:0002859)	1.86113196
51	Renal cortical cysts (HP:0000803)	1.85984245
52	Congenital primary aphakia (HP:0007707)	1.85864601
53	Pendular nystagmus (HP:0012043)	1.85744543
54	Bilateral microphthalmos (HP:0007633)	1.83998047
55	Abnormality of serine family amino acid metabolism (HP:0010894)	1.83569422
56	Abnormality of glycine metabolism (HP:0010895)	1.83569422
57	Gait imbalance (HP:0002141)	1.82881441
58	Cystic liver disease (HP:0006706)	1.82806894
59	Sloping forehead (HP:0000340)	1.82440622
60	Anencephaly (HP:0002323)	1.82059921
61	Abnormality of the preputium (HP:0100587)	1.81395854
62	Methylmalonic aciduria (HP:0012120)	1.81004362
63	Clubbing of toes (HP:0100760)	1.80827773
64	Preaxial hand polydactyly (HP:0001177)	1.80604319
65	Nephrogenic diabetes insipidus (HP:0009806)	1.79113478
66	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78755202
67	Abnormality of the duodenum (HP:0002246)	1.77885195
68	Glioma (HP:0009733)	1.75937225
69	Large for gestational age (HP:0001520)	1.74481024
70	Abnormality of vitamin B metabolism (HP:0004340)	1.73833299
71	Abnormality of the fovea (HP:0000493)	1.73435524
72	Birth length less than 3rd percentile (HP:0003561)	1.72904504
73	Male pseudohermaphroditism (HP:0000037)	1.72377603
74	Duodenal stenosis (HP:0100867)	1.72251404
75	Small intestinal stenosis (HP:0012848)	1.72251404
76	Postaxial hand polydactyly (HP:0001162)	1.72043002
77	Abnormal hair whorl (HP:0010721)	1.71374281
78	Polydipsia (HP:0001959)	1.70845108
79	Abnormal drinking behavior (HP:0030082)	1.70845108
80	Abnormality of serum amino acid levels (HP:0003112)	1.70421865
81	Abnormal lung lobation (HP:0002101)	1.70207659
82	Supernumerary spleens (HP:0009799)	1.70135410
83	Narrow forehead (HP:0000341)	1.70030363
84	Abnormality of B cell number (HP:0010975)	1.69693675
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.69031238
86	Abnormality of alanine metabolism (HP:0010916)	1.69031238
87	Hyperalaninemia (HP:0003348)	1.69031238
88	Short tibia (HP:0005736)	1.69010986
89	Triphalangeal thumb (HP:0001199)	1.68926898
90	Congenital hepatic fibrosis (HP:0002612)	1.68890880
91	Dandy-Walker malformation (HP:0001305)	1.67470296
92	Scrotal hypoplasia (HP:0000046)	1.67411643
93	Increased hepatocellular lipid droplets (HP:0006565)	1.67062207
94	Stenosis of the external auditory canal (HP:0000402)	1.66036442
95	B lymphocytopenia (HP:0010976)	1.65949597
96	Lipid accumulation in hepatocytes (HP:0006561)	1.65948527
97	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.65717893
98	Lissencephaly (HP:0001339)	1.64779430
99	Pancreatic islet-cell hyperplasia (HP:0004510)	1.64405146
100	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.62132238

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.62379665
2	PNCK	3.56429893
3	ACVR1B	3.19698055
4	TSSK6	3.12542619
5	TNIK	3.08920080
6	MKNK2	2.95670586
7	BMPR1B	2.81149611
8	WNK3	2.59549329
9	WEE1	2.57830067
10	ZAK	2.55625179
11	NUAK1	2.26988255
12	CASK	2.08913791
13	MST4	2.08826560
14	MKNK1	2.03763747
15	TRIM28	1.96233480
16	MAPK15	1.83845894
17	ADRBK2	1.71536584
18	MAP4K2	1.70221258
19	EIF2AK3	1.69474540
20	PLK3	1.68717333
21	BRSK2	1.51226860
22	VRK1	1.49851100
23	STK39	1.49517876
24	GRK1	1.47484320
25	BUB1	1.45730547
26	WNK4	1.40812324
27	PLK4	1.36027918
28	MAP3K4	1.33997968
29	SRPK1	1.31381745
30	OXSR1	1.30878865
31	NEK1	1.29082963
32	NLK	1.16596457
33	TTK	1.16014102
34	TXK	1.13431259
35	PBK	1.08345294
36	PLK2	1.08086428
37	FGFR2	1.07117507
38	STK38L	1.05441439
39	TAF1	1.04718163
40	INSRR	1.04168506
41	MAPK13	1.03502414
42	TGFBR1	1.02966433
43	TLK1	1.02815225
44	BCR	0.97394890
45	CSNK1G1	0.96351167
46	BRD4	0.89553006
47	CDC7	0.89479634
48	PASK	0.87248685
49	CSNK1G2	0.85446728
50	PLK1	0.83347158
51	EIF2AK1	0.82332367
52	STK3	0.78068088
53	ERBB3	0.76906746
54	FGFR1	0.74357690
55	CDK3	0.71755530
56	CAMKK2	0.70574401
57	DYRK2	0.69668187
58	EIF2AK2	0.68980774
59	PRKCG	0.66832674
60	PINK1	0.65664712
61	PRKCE	0.61771615
62	STK24	0.61421992
63	ATR	0.60819592
64	PIK3CA	0.59280719
65	ATM	0.58698468
66	TEC	0.57025982
67	STK16	0.55720217
68	YES1	0.55710003
69	NEK2	0.52010648
70	AKT3	0.51307466
71	CSNK1G3	0.50308751
72	PAK3	0.48733899
73	ADRBK1	0.44557196
74	CHEK2	0.43907557
75	IRAK1	0.40173247
76	PRKCQ	0.39803798
77	MAP2K6	0.39328662
78	CSNK1A1L	0.39173005
79	CAMK1G	0.37745865
80	ERBB2	0.36154822
81	RPS6KA4	0.36114447
82	BCKDK	0.33811934
83	CSNK1A1	0.33531238
84	TAOK3	0.32001537
85	DYRK3	0.31302362
86	CSNK2A1	0.27974929
87	MAP2K7	0.27089524
88	PRKCI	0.26921212
89	NTRK2	0.26734329
90	DAPK2	0.26683621
91	CSNK1E	0.25614417
92	PRKDC	0.25122158
93	ITK	0.24493666
94	CAMK2A	0.22937265
95	VRK2	0.22632412
96	PIM1	0.21731843
97	FLT3	0.21674522
98	STK4	0.21311161
99	PKN1	0.21284745
100	PRKG1	0.20964415

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.17719229
2	Homologous recombination_Homo sapiens_hsa03440	2.86296802
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.84725003
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.78263214
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.72514397
6	Basal transcription factors_Homo sapiens_hsa03022	2.59313675
7	Propanoate metabolism_Homo sapiens_hsa00640	2.33800289
8	RNA polymerase_Homo sapiens_hsa03020	2.28023714
9	Mismatch repair_Homo sapiens_hsa03430	2.20984375
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.20611427
11	Butanoate metabolism_Homo sapiens_hsa00650	2.13062416
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.07852473
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.03928191
14	RNA degradation_Homo sapiens_hsa03018	2.03719618
15	Steroid biosynthesis_Homo sapiens_hsa00100	2.00668478
16	Proteasome_Homo sapiens_hsa03050	1.99716009
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.99498806
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83458237
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.82558892
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.82140016
21	One carbon pool by folate_Homo sapiens_hsa00670	1.77939202
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77370913
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.77249741
24	Phototransduction_Homo sapiens_hsa04744	1.64596116
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64191007
26	Caffeine metabolism_Homo sapiens_hsa00232	1.51777128
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.46409098
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.44312593
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42676600
30	RNA transport_Homo sapiens_hsa03013	1.39556390
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37982450
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29948345
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.28272915
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.26160659
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18863948
36	Spliceosome_Homo sapiens_hsa03040	1.17389330
37	Parkinsons disease_Homo sapiens_hsa05012	1.17058384
38	DNA replication_Homo sapiens_hsa03030	1.16555621
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06752453
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.03881882
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02320635
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.01333209
43	Base excision repair_Homo sapiens_hsa03410	0.98759988
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.97476551
45	Peroxisome_Homo sapiens_hsa04146	0.96482877
46	Purine metabolism_Homo sapiens_hsa00230	0.91521574
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89264590
48	Huntingtons disease_Homo sapiens_hsa05016	0.87577287
49	Nicotine addiction_Homo sapiens_hsa05033	0.87257291
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84976060
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84003901
52	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83404771
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.81232145
54	Cell cycle_Homo sapiens_hsa04110	0.80496718
55	Regulation of autophagy_Homo sapiens_hsa04140	0.79805079
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77464018
57	Retinol metabolism_Homo sapiens_hsa00830	0.76689627
58	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76129701
59	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.75282146
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71361566
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.71034157
62	mRNA surveillance pathway_Homo sapiens_hsa03015	0.70712090
63	Folate biosynthesis_Homo sapiens_hsa00790	0.70436424
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.69728071
65	Taste transduction_Homo sapiens_hsa04742	0.69266696
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68576089
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67537014
68	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.67459981
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64890570
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.64257627
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.62728226
72	p53 signaling pathway_Homo sapiens_hsa04115	0.61915557
73	Olfactory transduction_Homo sapiens_hsa04740	0.58225258
74	Fatty acid degradation_Homo sapiens_hsa00071	0.57977288
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57371448
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56219104
77	Metabolic pathways_Homo sapiens_hsa01100	0.56172979
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.53167017
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.51782654
80	Sulfur metabolism_Homo sapiens_hsa00920	0.50184813
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48381843
82	Mineral absorption_Homo sapiens_hsa04978	0.48065959
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46713871
84	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46252150
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.46249530
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45030433
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.43403665
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42206864
89	Ribosome_Homo sapiens_hsa03010	0.41985174
90	Alzheimers disease_Homo sapiens_hsa05010	0.41802008
91	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.39689078
92	Glutathione metabolism_Homo sapiens_hsa00480	0.39448316
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38257316
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.36996936
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.35273855
96	Type I diabetes mellitus_Homo sapiens_hsa04940	0.34137020
97	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.31640763
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30333370
99	Circadian rhythm_Homo sapiens_hsa04710	0.28323815
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.26497913

TMEM170A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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