TMEM171

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)6.32035586
2positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.90495689
3positive regulation of interferon-alpha production (GO:0032727)5.47496020
4protein maturation by protein folding (GO:0022417)5.35608184
5regulation of interferon-alpha production (GO:0032647)5.22194804
6cellular response to virus (GO:0098586)5.03843071
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.96666486
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.96666486
9modulation by symbiont of host immune response (GO:0052553)4.96666486
10positive regulation by symbiont of host defense response (GO:0052509)4.96666486
11modulation by symbiont of host defense response (GO:0052031)4.96666486
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.96666486
13proteasome assembly (GO:0043248)4.74395982
14regulation of mononuclear cell migration (GO:0071675)4.72813214
15positive regulation of actin filament depolymerization (GO:0030836)4.65591753
16lymphocyte chemotaxis (GO:0048247)4.49973628
17Golgi transport vesicle coating (GO:0048200)4.49920801
18COPI coating of Golgi vesicle (GO:0048205)4.49920801
19actin filament depolymerization (GO:0030042)4.44458354
20type B pancreatic cell proliferation (GO:0044342)4.42237505
21positive regulation of pseudopodium assembly (GO:0031274)4.40378076
22maintenance of gastrointestinal epithelium (GO:0030277)4.26343761
23extracellular fibril organization (GO:0043206)4.23555664
24eosinophil migration (GO:0072677)4.22488316
25lipopolysaccharide biosynthetic process (GO:0009103)4.13668883
26barbed-end actin filament capping (GO:0051016)4.13238368
27skin morphogenesis (GO:0043589)4.06205627
28macrophage chemotaxis (GO:0048246)4.04510456
29response to type I interferon (GO:0034340)4.03065010
30regulation of RIG-I signaling pathway (GO:0039535)3.98736362
31positive regulation of interleukin-1 secretion (GO:0050716)3.95391368
32regulation of pseudopodium assembly (GO:0031272)3.91370207
33muscle cell migration (GO:0014812)3.91364616
34fibril organization (GO:0097435)3.89676289
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.88303460
36hepatocyte apoptotic process (GO:0097284)3.86460329
37membrane raft organization (GO:0031579)3.85178347
38protein retention in ER lumen (GO:0006621)3.84077122
39cellular response to type I interferon (GO:0071357)3.83627542
40type I interferon signaling pathway (GO:0060337)3.83627542
41regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.80072639
42immunoglobulin mediated immune response (GO:0016064)3.75121865
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74459778
44virion attachment to host cell (GO:0019062)3.73930217
45adhesion of symbiont to host cell (GO:0044650)3.73930217
46positive regulation of interferon-beta production (GO:0032728)3.73664819
47nucleotide-sugar biosynthetic process (GO:0009226)3.68783480
48neutrophil activation involved in immune response (GO:0002283)3.67851621
49regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.56392220
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.52630954
51endothelial tube morphogenesis (GO:0061154)3.51114646
52morphogenesis of an endothelium (GO:0003159)3.51114646
53desmosome organization (GO:0002934)3.50008384
54lipopolysaccharide metabolic process (GO:0008653)3.47934325
55cellular response to interferon-alpha (GO:0035457)3.47627453
56regulation of interleukin-1 secretion (GO:0050704)3.44627253
57cellular response to zinc ion (GO:0071294)3.42542235
58negative regulation of viral genome replication (GO:0045071)3.41645562
59regulation of viral entry into host cell (GO:0046596)3.36848060
60interferon-gamma-mediated signaling pathway (GO:0060333)3.36836496
61response to peptidoglycan (GO:0032494)3.36596692
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33181007
63response to host immune response (GO:0052572)3.33181007
64GDP-mannose metabolic process (GO:0019673)3.30920602
65negative regulation of protein tyrosine kinase activity (GO:0061099)3.30535146
66positive regulation of Cdc42 GTPase activity (GO:0043089)3.29537138
67negative regulation of viral entry into host cell (GO:0046597)3.28281321
68nuclear envelope reassembly (GO:0031468)3.24356690
69mitotic nuclear envelope reassembly (GO:0007084)3.24356690
70positive regulation of glycoprotein biosynthetic process (GO:0010560)3.24234358
71regulation of respiratory burst (GO:0060263)3.24066604
72regulation of interferon-beta production (GO:0032648)3.21935759
73intestinal epithelial cell development (GO:0060576)3.19847003
74chondrocyte proliferation (GO:0035988)3.19453709
75bile acid and bile salt transport (GO:0015721)3.18973798
76positive regulation of chemokine biosynthetic process (GO:0045080)3.18364006
77diol metabolic process (GO:0034311)3.16525125
78positive regulation of interleukin-1 production (GO:0032732)3.16147736
79regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.15011111
80cellular response to exogenous dsRNA (GO:0071360)3.14305434
81renal system process involved in regulation of blood volume (GO:0001977)3.14267410
82response to interferon-alpha (GO:0035455)3.12781985
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11213911
84response to host (GO:0075136)3.11213911
85response to host defenses (GO:0052200)3.11213911
86regulation of viral release from host cell (GO:1902186)3.10970372
87oligosaccharide biosynthetic process (GO:0009312)3.10214214
88epithelial structure maintenance (GO:0010669)3.09357633
89nucleoside diphosphate biosynthetic process (GO:0009133)3.08845327
90cellular copper ion homeostasis (GO:0006878)3.06582569
91establishment of viral latency (GO:0019043)3.06083778
92adhesion of symbiont to host (GO:0044406)3.04244010
93cytidine metabolic process (GO:0046087)3.03977685
94cytidine catabolic process (GO:0006216)3.03977685
95cytidine deamination (GO:0009972)3.03977685
96cellular extravasation (GO:0045123)3.03624873
97Arp2/3 complex-mediated actin nucleation (GO:0034314)3.02766338
98macrophage activation involved in immune response (GO:0002281)3.02764117
99positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.98860807
100regulation of extracellular matrix disassembly (GO:0010715)2.96799085
101striated muscle atrophy (GO:0014891)2.95532927
102positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94926194
103intestinal absorption (GO:0050892)2.94608022
104positive regulation of glycoprotein metabolic process (GO:1903020)2.94598656
105positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.90790009
106nucleotide transmembrane transport (GO:1901679)2.90776990
107fibrinolysis (GO:0042730)2.89825608
108monocyte chemotaxis (GO:0002548)2.88724495
109B cell mediated immunity (GO:0019724)2.88679112
110galactose metabolic process (GO:0006012)2.88164322
111regulation of protein glycosylation (GO:0060049)2.87943214
112neutrophil chemotaxis (GO:0030593)2.86674150
113calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.85823941
114UDP-N-acetylglucosamine metabolic process (GO:0006047)2.84547153
115thrombin receptor signaling pathway (GO:0070493)2.83388887
116negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.83379363
117regulation of metalloenzyme activity (GO:0048552)2.83180987
118regulation of podosome assembly (GO:0071801)2.83028682
119neutrophil migration (GO:1990266)2.82850003
120negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.82537550
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81999545
122regulation of defense response to virus by host (GO:0050691)2.81771535
123positive regulation of response to cytokine stimulus (GO:0060760)2.81760746
124positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.81731877
125regulation of guanylate cyclase activity (GO:0031282)2.81690170
126regulation of integrin activation (GO:0033623)2.80253565
127positive regulation of toll-like receptor signaling pathway (GO:0034123)2.79844876
128eosinophil chemotaxis (GO:0048245)2.78997570
129positive regulation of interleukin-1 beta secretion (GO:0050718)2.77163858
130response to interferon-beta (GO:0035456)2.75652605
131cellular response to interferon-beta (GO:0035458)2.74934021
132regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73397397
133regulation of vitamin metabolic process (GO:0030656)2.72262261
134negative regulation of defense response to virus (GO:0050687)2.71736310
135endocardial cushion development (GO:0003197)2.68816992
136positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.68074617
137positive regulation of monocyte chemotaxis (GO:0090026)2.67839988
138glomerular visceral epithelial cell development (GO:0072015)2.67427639
139regulation of cellular amino acid metabolic process (GO:0006521)2.66066515
140positive regulation of interleukin-8 secretion (GO:2000484)2.66037327
141cell adhesion mediated by integrin (GO:0033627)2.65215530
142cellular response to interferon-gamma (GO:0071346)2.65188186
143positive regulation of type 2 immune response (GO:0002830)2.64259808
144regulation of integrin-mediated signaling pathway (GO:2001044)2.63669904
145negative regulation of viral process (GO:0048525)2.63148858
146actin nucleation (GO:0045010)2.61584360
147protein localization to endosome (GO:0036010)2.61322337
148granulocyte activation (GO:0036230)2.60755436
149natural killer cell mediated cytotoxicity (GO:0042267)2.60091817
150natural killer cell mediated immunity (GO:0002228)2.60091817
151negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59330570
152establishment of integrated proviral latency (GO:0075713)2.59013703
153response to copper ion (GO:0046688)2.58016235
154ventricular cardiac muscle cell development (GO:0055015)2.57838928
155angiotensin maturation (GO:0002003)2.56398317
156sulfate transmembrane transport (GO:1902358)2.56052519
157mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55984771
158mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55984771
159T-helper 1 type immune response (GO:0042088)2.55930549
160positive regulation of actin cytoskeleton reorganization (GO:2000251)2.55514001
161positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55499114
162positive regulation of interleukin-6 production (GO:0032755)2.55291257
163substrate-dependent cell migration (GO:0006929)2.54635346
164antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.53899049
165regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53879327
166NADH metabolic process (GO:0006734)2.53832227
167cellular response to cadmium ion (GO:0071276)2.53640938
168lymphocyte migration (GO:0072676)2.53596369
169galactose catabolic process (GO:0019388)2.53029122
170anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51382696
171negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.51006402
172pyrimidine-containing compound transmembrane transport (GO:0072531)2.50334388
173protein hydroxylation (GO:0018126)2.49922933
174glucuronate metabolic process (GO:0019585)2.46599571
175uronic acid metabolic process (GO:0006063)2.46599571
176membrane budding (GO:0006900)2.46090715
177cellular glucuronidation (GO:0052695)2.45699260
178decidualization (GO:0046697)2.44627110
179retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42527177
180positive regulation of endothelial cell differentiation (GO:0045603)2.42491609
181detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.41735576
182negative regulation of ligase activity (GO:0051352)2.40603240
183negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.40603240
184cellular response to pH (GO:0071467)2.40147895
185regulation of actin filament depolymerization (GO:0030834)2.39697960
186regulation of cellular extravasation (GO:0002691)2.39177044
187regulation of interleukin-8 secretion (GO:2000482)2.38704783
188negative regulation of protein autophosphorylation (GO:0031953)2.38008099
189hyaluronan catabolic process (GO:0030214)2.37890886
190regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.36805989
191negative regulation of chondrocyte differentiation (GO:0032331)2.36693479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.45900821
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.99304311
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.84640645
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.81924839
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.13938172
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.70497043
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.92312227
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.91861115
9STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.78438677
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.63414970
11SOX2_20726797_ChIP-Seq_SW620_Human2.62322271
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.46775476
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.45286512
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.43566443
15* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.39623431
16* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35365124
17* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.31945929
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31563478
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28739055
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21059989
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20403454
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.20076039
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18665229
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.17886512
25AR_21909140_ChIP-Seq_LNCAP_Human2.08914480
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99699347
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97706371
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96347350
29GATA4_25053715_ChIP-Seq_YYC3_Human1.94403196
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.94304491
31GATA6_25053715_ChIP-Seq_YYC3_Human1.88649921
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88013777
33* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.84011663
34CLOCK_20551151_ChIP-Seq_293T_Human1.79134368
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77556614
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77545668
37ZNF263_19887448_ChIP-Seq_K562_Human1.73613592
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71274397
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.69977751
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66490662
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63999470
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.63557978
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60450041
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57785442
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55942148
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50521209
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47747605
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46649670
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.46456384
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44964440
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43792457
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43229237
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40075486
54BRD4_25478319_ChIP-Seq_HGPS_Human1.39073719
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37381754
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36909413
57ATF3_27146783_Chip-Seq_COLON_Human1.35946021
58JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35233558
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35029111
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35029111
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33672467
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.33137013
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30950765
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.30810384
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28685715
66* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28333368
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27101892
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.26685973
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26318997
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25071751
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24439664
72RACK7_27058665_Chip-Seq_MCF-7_Human1.23589775
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23174601
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21717552
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21044137
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20488692
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20268805
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.19779309
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19359131
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18939158
81EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18430881
82CSB_26484114_Chip-Seq_FIBROBLAST_Human1.17854166
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17813322
84TFEB_21752829_ChIP-Seq_HELA_Human1.17553859
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17162366
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15120752
87KLF5_25053715_ChIP-Seq_YYC3_Human1.13660561
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12953549
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12509603
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11100047
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10553931
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10344124
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09648692
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09519310
95GABP_17652178_ChIP-ChIP_JURKAT_Human1.09510066
96* RXR_22158963_ChIP-Seq_LIVER_Mouse1.09381035
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08721996
98SPI1_23547873_ChIP-Seq_NB4_Human1.07911430
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.06620094
100CJUN_26792858_Chip-Seq_BT549_Human1.05992829
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04857840
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04830010
103FOXM1_23109430_ChIP-Seq_U2OS_Human1.04701841
104TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03596020
105CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02569331
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02470683
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02314041
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02190320
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01836492
110SPI1_23127762_ChIP-Seq_K562_Human0.98727635
111* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98592973
112UBF1/2_26484160_Chip-Seq_HMECs_Human0.98556528
113NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98507082
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.97726442
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97339558
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96094143
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95359564
118EOMES_21245162_ChIP-Seq_HESCs_Human0.95009738
119LXR_22158963_ChIP-Seq_LIVER_Mouse0.94768694
120DCP1A_22483619_ChIP-Seq_HELA_Human0.94599102
121FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94404576
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94396296
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94393140
124* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94292322
125* RUNX1_22412390_ChIP-Seq_EML_Mouse0.93980138
126SRF_21415370_ChIP-Seq_HL-1_Mouse0.92122562
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92094321
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91066611
129* GATA3_24758297_ChIP-Seq_MCF-7_Human0.90898066
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90301202
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90257220
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.89743585
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87830996
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86084420
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85296317
136SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85258870
137CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83505678
138RUNX1_27514584_Chip-Seq_MCF-7_Human0.83230723
139NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82222083
140PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81018428
141* VDR_24787735_ChIP-Seq_THP-1_Human0.80661275
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79830364
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.79328333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.21864509
2MP0008438_abnormal_cutaneous_collagen4.04297734
3MP0003950_abnormal_plasma_membrane3.69288347
4MP0009840_abnormal_foam_cell3.07231935
5MP0006082_CNS_inflammation2.94421394
6MP0009785_altered_susceptibility_to2.92768752
7MP0004272_abnormal_basement_membrane2.87780802
8MP0002148_abnormal_hypersensitivity_rea2.51782468
9MP0001835_abnormal_antigen_presentation2.46919966
10MP0000462_abnormal_digestive_system2.43652605
11MP0010155_abnormal_intestine_physiology2.42484690
12MP0010030_abnormal_orbit_morphology2.40287769
13MP0000490_abnormal_crypts_of2.39499006
14MP0003436_decreased_susceptibility_to2.38205494
15MP0005167_abnormal_blood-brain_barrier2.37430454
16MP0002139_abnormal_hepatobiliary_system2.32809395
17MP0010352_gastrointestinal_tract_polyps2.31033187
18MP0005670_abnormal_white_adipose2.28000486
19MP0005058_abnormal_lysosome_morphology2.25656867
20MP0001542_abnormal_bone_strength2.13218316
21MP0010368_abnormal_lymphatic_system2.11152910
22MP0003303_peritoneal_inflammation2.09843055
23MP0003866_abnormal_defecation2.08620617
24MP0005025_abnormal_response_to2.08310530
25MP0008004_abnormal_stomach_pH2.07206873
26MP0003300_gastrointestinal_ulcer2.06069006
27MP0005310_abnormal_salivary_gland2.05209851
28MP0003315_abnormal_perineum_morphology2.03240073
29MP0005275_abnormal_skin_tensile2.02107463
30MP0004947_skin_inflammation2.00712484
31MP0005000_abnormal_immune_tolerance1.97469530
32MP0005165_increased_susceptibility_to1.92389070
33MP0001663_abnormal_digestive_system1.90347492
34MP0005381_digestive/alimentary_phenotyp1.89472518
35MP0002102_abnormal_ear_morphology1.89379817
36MP0003724_increased_susceptibility_to1.87029548
37MP0001873_stomach_inflammation1.85177435
38MP0006054_spinal_hemorrhage1.83663105
39MP0003279_aneurysm1.81160177
40MP0005360_urolithiasis1.79949263
41MP0009780_abnormal_chondrocyte_physiolo1.79080587
42MP0002419_abnormal_innate_immunity1.78119095
43MP0003191_abnormal_cellular_cholesterol1.77994794
44MP0004043_abnormal_pH_regulation1.77232181
45MP0004264_abnormal_extraembryonic_tissu1.77178420
46MP0004782_abnormal_surfactant_physiolog1.76189019
47MP0003705_abnormal_hypodermis_morpholog1.66173475
48MP0001958_emphysema1.64809245
49MP0002877_abnormal_melanocyte_morpholog1.62567543
50MP0005085_abnormal_gallbladder_physiolo1.61297231
51MP0005377_hearing/vestibular/ear_phenot1.60958686
52MP0003878_abnormal_ear_physiology1.60958686
53MP0003806_abnormal_nucleotide_metabolis1.60302134
54MP0004510_myositis1.57768828
55MP0001790_abnormal_immune_system1.54477822
56MP0005387_immune_system_phenotype1.54477822
57MP0003283_abnormal_digestive_organ1.50726568
58MP0002452_abnormal_antigen_presenting1.50634352
59MP0001533_abnormal_skeleton_physiology1.50340746
60MP0003453_abnormal_keratinocyte_physiol1.49363451
61MP0002060_abnormal_skin_morphology1.45015249
62MP0000751_myopathy1.43545434
63MP0000604_amyloidosis1.43011637
64MP0010678_abnormal_skin_adnexa1.41822595
65MP0000343_altered_response_to1.40628574
66MP0005197_abnormal_uvea_morphology1.37217519
67MP0001845_abnormal_inflammatory_respons1.36940699
68MP0000749_muscle_degeneration1.36772170
69MP0000477_abnormal_intestine_morphology1.35112324
70MP0002723_abnormal_immune_serum1.33594467
71MP0001666_abnormal_nutrient_absorption1.33027707
72MP0003693_abnormal_embryo_hatching1.32821961
73MP0000685_abnormal_immune_system1.32684091
74MP0005330_cardiomyopathy1.31053319
75MP0005451_abnormal_body_composition1.30849836
76MP0005501_abnormal_skin_physiology1.30447658
77MP0002822_catalepsy1.28859994
78MP0001800_abnormal_humoral_immune1.27635201
79MP0001243_abnormal_dermal_layer1.25707074
80MP0001881_abnormal_mammary_gland1.24920431
81MP0003091_abnormal_cell_migration1.23360350
82MP0001819_abnormal_immune_cell1.21424189
83MP0002896_abnormal_bone_mineralization1.20937793
84MP0009333_abnormal_splenocyte_physiolog1.20099258
85MP0009643_abnormal_urine_homeostasis1.20059757
86MP0008469_abnormal_protein_level1.18917874
87MP0003183_abnormal_peptide_metabolism1.18629224
88MP0000762_abnormal_tongue_morphology1.15780007
89MP0005395_other_phenotype1.15643248
90MP0002420_abnormal_adaptive_immunity1.15410009
91MP0003718_maternal_effect1.15273901
92MP0005408_hypopigmentation1.14435677
93MP0003186_abnormal_redox_activity1.13832126
94MP0005671_abnormal_response_to1.12100996
95MP0009764_decreased_sensitivity_to1.10864947
96MP0000538_abnormal_urinary_bladder1.10706947
97MP0002006_tumorigenesis1.10279908
98MP0005166_decreased_susceptibility_to1.08729744
99MP0002277_abnormal_respiratory_mucosa1.08347926
100MP0008775_abnormal_heart_ventricle1.08290242
101MP0008260_abnormal_autophagy1.05836179
102MP0005023_abnormal_wound_healing1.05387374
103MP0002136_abnormal_kidney_physiology1.03309431
104MP0004858_abnormal_nervous_system1.02366885
105MP0005365_abnormal_bile_salt1.01682533
106MP0003448_altered_tumor_morphology1.01605662
107MP0002405_respiratory_system_inflammati1.00405197
108MP0001853_heart_inflammation0.97666623
109MP0002796_impaired_skin_barrier0.95039341
110MP0008875_abnormal_xenobiotic_pharmacok0.94842111
111MP0009379_abnormal_foot_pigmentation0.94527643
112MP0003566_abnormal_cell_adhesion0.92840320
113MP0005257_abnormal_intraocular_pressure0.92553226
114MP0000750_abnormal_muscle_regeneration0.90917345
115MP0005508_abnormal_skeleton_morphology0.90226119
116MP0004147_increased_porphyrin_level0.89610515
117MP0003075_altered_response_to0.89035942
118MP0005464_abnormal_platelet_physiology0.88981076
119MP0003941_abnormal_skin_development0.88376040
120MP0003646_muscle_fatigue0.87870019
121MP0001299_abnormal_eye_distance/0.86596508
122MP0001216_abnormal_epidermal_layer0.86559156
123MP0010386_abnormal_urinary_bladder0.84729987
124MP0005503_abnormal_tendon_morphology0.83158788
125MP0005367_renal/urinary_system_phenotyp0.81808604
126MP0000516_abnormal_urinary_system0.81808604
127MP0000627_abnormal_mammary_gland0.81325803
128MP0000858_altered_metastatic_potential0.81306343
129MP0001849_ear_inflammation0.81176684
130MP0005164_abnormal_response_to0.80826110
131MP0001765_abnormal_ion_homeostasis0.80781695
132MP0004185_abnormal_adipocyte_glucose0.80647773
133MP0002295_abnormal_pulmonary_circulatio0.79912284
134MP0002332_abnormal_exercise_endurance0.78971254
135MP0005076_abnormal_cell_differentiation0.78413650
136MP0002098_abnormal_vibrissa_morphology0.76630315
137MP0001756_abnormal_urination0.76332989
138MP0000383_abnormal_hair_follicle0.76030304
139MP0005171_absent_coat_pigmentation0.75673715
140MP0001664_abnormal_digestion0.74103527
141MP0002138_abnormal_hepatobiliary_system0.74035128
142MP0010307_abnormal_tumor_latency0.73730960
143MP0000470_abnormal_stomach_morphology0.73612862
144MP0005083_abnormal_biliary_tract0.73417313
145MP0000537_abnormal_urethra_morphology0.73230578
146MP0001879_abnormal_lymphatic_vessel0.72877078
147MP0003252_abnormal_bile_duct0.72683332
148MP0004019_abnormal_vitamin_homeostasis0.72422530
149MP0000681_abnormal_thyroid_gland0.70849648
150MP0002168_other_aberrant_phenotype0.70043088
151MP0000767_abnormal_smooth_muscle0.70039593
152MP0009278_abnormal_bone_marrow0.70032030
153MP0005390_skeleton_phenotype0.69780470
154MP0002166_altered_tumor_susceptibility0.69567429
155MP0005584_abnormal_enzyme/coenzyme_acti0.68890116
156MP0002177_abnormal_outer_ear0.68532860
157MP0003868_abnormal_feces_composition0.67701044

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.33238138
2Recurrent abscess formation (HP:0002722)4.84258019
3Recurrent bacterial skin infections (HP:0005406)4.73954658
4Vacuolated lymphocytes (HP:0001922)4.70317503
5Pustule (HP:0200039)4.37790191
6Osteolytic defects of the phalanges of the hand (HP:0009771)4.16219319
7Reduced subcutaneous adipose tissue (HP:0003758)4.01380129
8Ileus (HP:0002595)3.99403169
9Cupped ribs (HP:0000887)3.91094236
10Eczematoid dermatitis (HP:0000976)3.77927748
11Abnormality of macrophages (HP:0004311)3.71098676
12Follicular hyperkeratosis (HP:0007502)3.66257070
13Villous atrophy (HP:0011473)3.63420722
14Abnormality of small intestinal villus morphology (HP:0011472)3.63420722
15Prostate neoplasm (HP:0100787)3.61496391
16Autoimmune thrombocytopenia (HP:0001973)3.60815543
17Cardiovascular calcification (HP:0011915)3.45707948
18Vertebral compression fractures (HP:0002953)3.44744431
19Protrusio acetabuli (HP:0003179)3.43534065
20Vascular calcification (HP:0004934)3.37244229
21Systemic lupus erythematosus (HP:0002725)3.29409426
22Cervical subluxation (HP:0003308)3.26784942
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.22064286
24Hyperactive renin-angiotensin system (HP:0000841)3.21294100
25Male infertility (HP:0003251)3.19359303
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.16447427
27Flat acetabular roof (HP:0003180)3.15327435
28Congenital sensorineural hearing impairment (HP:0008527)3.14866427
29Recurrent gram-negative bacterial infections (HP:0005420)3.06432835
30Metabolic alkalosis (HP:0200114)3.03225775
31Abnormality of chloride homeostasis (HP:0011422)3.02892637
32Axonal loss (HP:0003447)3.01013883
33Abnormality of the distal phalanges of the toes (HP:0010182)2.99664863
34Intrahepatic cholestasis (HP:0001406)2.94814400
35Elevated erythrocyte sedimentation rate (HP:0003565)2.89726602
36Glucose intolerance (HP:0000833)2.88266461
37Orchitis (HP:0100796)2.83530935
38Atrophic scars (HP:0001075)2.77713351
39Short nail (HP:0001799)2.73300132
40Pili torti (HP:0003777)2.71600384
41Dysostosis multiplex (HP:0000943)2.70912338
42Recurrent skin infections (HP:0001581)2.70633330
43Entropion (HP:0000621)2.68044160
44Rough bone trabeculation (HP:0100670)2.67360173
45Esophageal varix (HP:0002040)2.64792809
46Right ventricular cardiomyopathy (HP:0011663)2.64523663
47Interstitial pulmonary disease (HP:0006530)2.63294453
48Micronodular cirrhosis (HP:0001413)2.60418653
49Spinal cord compression (HP:0002176)2.57924001
50Myositis (HP:0100614)2.57278296
51Hypokinesia (HP:0002375)2.53560591
52Abdominal distention (HP:0003270)2.49152539
53Sensorimotor neuropathy (HP:0007141)2.48309010
54Gingivitis (HP:0000230)2.46803430
55Tongue fasciculations (HP:0001308)2.45763562
56Ankle contracture (HP:0006466)2.45685079
57Increased cerebral lipofuscin (HP:0011813)2.45224964
58Amyloidosis (HP:0011034)2.45097580
59Gastrointestinal dysmotility (HP:0002579)2.44211078
60Neonatal short-limb short stature (HP:0008921)2.43858709
61Periodontitis (HP:0000704)2.43746681
62Nausea (HP:0002018)2.43715027
63Abnormality of the costochondral junction (HP:0000919)2.42721807
64Optic neuritis (HP:0100653)2.40319015
65Retrobulbar optic neuritis (HP:0100654)2.40319015
66Ventricular fibrillation (HP:0001663)2.39825526
67Distal lower limb muscle weakness (HP:0009053)2.39656541
68Adrenal hypoplasia (HP:0000835)2.39498675
69Abnormal tarsal ossification (HP:0008369)2.39422106
70Spinal rigidity (HP:0003306)2.38029190
71Alopecia of scalp (HP:0002293)2.36622959
72Disinhibition (HP:0000734)2.35327339
73Microglossia (HP:0000171)2.35135760
74Septate vagina (HP:0001153)2.35039682
75Abnormality of the 1st metacarpal (HP:0010009)2.34951957
76Wormian bones (HP:0002645)2.34519910
77Ureteral stenosis (HP:0000071)2.34124728
78Glomerulonephritis (HP:0000099)2.33536432
79Cholecystitis (HP:0001082)2.33180717
80Abnormal gallbladder physiology (HP:0012438)2.33180717
81Distal upper limb amyotrophy (HP:0007149)2.32071106
82Upper limb amyotrophy (HP:0009129)2.32071106
83Hydroxyprolinuria (HP:0003080)2.31708577
84Abnormality of proline metabolism (HP:0010907)2.31708577
85Petechiae (HP:0000967)2.31533176
86Abnormal glucose tolerance (HP:0001952)2.29520569
87Increased serum pyruvate (HP:0003542)2.29382846
88Abnormal trabecular bone morphology (HP:0100671)2.28442243
89Sparse eyelashes (HP:0000653)2.28285316
90Cheilitis (HP:0100825)2.26604938
91Polycythemia (HP:0001901)2.26450371
92Muscle fibrillation (HP:0010546)2.25269256
93Conjugated hyperbilirubinemia (HP:0002908)2.25037154
94Upper limb muscle weakness (HP:0003484)2.24887415
95Increased connective tissue (HP:0009025)2.23000239
96Breech presentation (HP:0001623)2.22555113
97Rectal prolapse (HP:0002035)2.21799032
98Abnormality of carpal bone ossification (HP:0006257)2.21352348
99Ureteral obstruction (HP:0006000)2.19576837
100Abnormality of glycolysis (HP:0004366)2.19334917
101Flat capital femoral epiphysis (HP:0003370)2.19235251
102Abnormality of the distal phalanx of the thumb (HP:0009617)2.19076012
103Distal lower limb amyotrophy (HP:0008944)2.18431125
104Abnormality of the umbilical cord (HP:0010881)2.16498036
105Mediastinal lymphadenopathy (HP:0100721)2.14657125
106Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11861768
107Focal segmental glomerulosclerosis (HP:0000097)2.09918062
108Hand muscle atrophy (HP:0009130)2.08967585
109Arterial tortuosity (HP:0005116)2.08171987
110Mildly elevated creatine phosphokinase (HP:0008180)2.07613694
111Abnormal hair laboratory examination (HP:0003328)2.07564718
112Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07533257
113Alkalosis (HP:0001948)2.07424154
114Metaphyseal cupping (HP:0003021)2.06336494
115Premature loss of primary teeth (HP:0006323)2.05967353
116Fat malabsorption (HP:0002630)2.03920116
117Cone-rod dystrophy (HP:0000548)2.03747942
118Basal ganglia calcification (HP:0002135)2.03684212
119Abnormalities of placenta or umbilical cord (HP:0001194)2.02620438
120Increased neuronal autofluorescent lipopigment (HP:0002074)2.02322218
121Insulin resistance (HP:0000855)2.02264038
122Ovoid vertebral bodies (HP:0003300)2.02085079
123Multiple lipomas (HP:0001012)2.01809480
124Recurrent fungal infections (HP:0002841)2.00297428
125Tetany (HP:0001281)1.99197658
126Type I transferrin isoform profile (HP:0003642)1.99083838
127Abnormality of renin-angiotensin system (HP:0000847)1.98255880
128Abnormality of glycolipid metabolism (HP:0010969)1.98137946
129Abnormality of liposaccharide metabolism (HP:0010968)1.98137946
130Abnormality of glycosphingolipid metabolism (HP:0004343)1.98137946
131Blue sclerae (HP:0000592)1.96119325
132Congenital ichthyosiform erythroderma (HP:0007431)1.95703987
133Progressive hearing impairment (HP:0001730)1.95473113
134Decreased circulating renin level (HP:0003351)1.95378285
135Nephritis (HP:0000123)1.94432512
136Generalized amyotrophy (HP:0003700)1.93120552
137Elbow flexion contracture (HP:0002987)1.91373347
138Anorexia (HP:0002039)1.90356292
139Urinary glycosaminoglycan excretion (HP:0003541)1.87292930
140Mucopolysacchariduria (HP:0008155)1.87292930
141Myocardial infarction (HP:0001658)1.87104345
142Thick nail (HP:0001805)1.86665304
143Prolonged neonatal jaundice (HP:0006579)1.85716140
144Natal tooth (HP:0000695)1.84180340
145Hyperparathyroidism (HP:0000843)1.83909961
146Abnormality of polysaccharide metabolism (HP:0011012)1.83868199
147Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83868199
148Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83868199
149Flattened epiphyses (HP:0003071)1.83775212
150Coxa vara (HP:0002812)1.83640623
151Malnutrition (HP:0004395)1.82730470
152Patchy hypopigmentation of hair (HP:0011365)1.82103519
153Abnormal ossification of hand bones (HP:0005921)1.82013229
154Abnormality of the phalanges of the hallux (HP:0010057)1.81255375
155Muscle stiffness (HP:0003552)1.81231432
156Delayed CNS myelination (HP:0002188)1.81191046
157Hyponatremia (HP:0002902)1.80561315
158Overlapping toe (HP:0001845)1.79916819
159Vascular tortuosity (HP:0004948)1.79364549
160Abnormal delivery (HP:0001787)1.78876150
161Colitis (HP:0002583)1.78246918
162Vasculitis (HP:0002633)1.77933538
163Amniotic constriction ring (HP:0009775)1.77004287
164Abnormality of placental membranes (HP:0011409)1.77004287
165White forelock (HP:0002211)1.76710442
166Pulmonary fibrosis (HP:0002206)1.76596520
167Agnosia (HP:0010524)1.75635794
168Xerostomia (HP:0000217)1.75166515
169Curly hair (HP:0002212)1.75006584
170Abnormal hand bone ossification (HP:0010660)1.74011576
171Neoplasm of head and neck (HP:0012288)1.73437603
172Esophageal neoplasm (HP:0100751)1.73437603
173Urticaria (HP:0001025)1.73432897
174Progressive visual loss (HP:0000529)1.72374907
175Aortic dissection (HP:0002647)1.70341908
176Recurrent cutaneous fungal infections (HP:0011370)1.68912994
177Chronic mucocutaneous candidiasis (HP:0002728)1.68912994
178Inflammation of the large intestine (HP:0002037)1.68373553
179Osteolytic defects of the hand bones (HP:0009699)1.65619491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK14.30525745
2LIMK13.58971515
3TAOK13.15386972
4PIK3CA2.98126061
5LMTK22.95685500
6ARAF2.88280341
7IKBKE2.75400463
8KSR22.61473208
9MST1R2.55243759
10MST42.54330556
11EPHA22.45155213
12PBK2.38112738
13EIF2AK12.35411486
14RIPK12.22932648
15BUB12.19989332
16VRK22.17492474
17MAP3K142.00918704
18MAP2K21.87887515
19MAP3K91.84375005
20PIM21.84292502
21FRK1.82405296
22STK101.81272256
23DDR21.78680161
24PDK21.72765491
25TAOK31.65136624
26PRKG21.58576393
27RIPK41.56389259
28ERN11.55974943
29MAP3K111.53973667
30TYK21.53844141
31MOS1.53519099
32TESK11.47850840
33IKBKB1.47410622
34NEK11.43209772
35TGFBR21.36681101
36TTK1.34087282
37MAP3K81.29890991
38EPHB21.28393935
39MAP3K131.25969736
40MAPKAPK31.22798743
41MAP3K31.19693611
42RAF11.19509228
43BRAF1.19243768
44ERBB41.10167664
45NEK91.06127456
46ACVR1B1.05667405
47STK38L1.05322222
48ABL21.00288926
49NME10.99085338
50MYLK0.97793973
51TTN0.93781593
52KDR0.92506766
53GRK60.91268506
54KIT0.90456651
55TAOK20.89811553
56BCKDK0.88202360
57CHUK0.87464427
58STK30.86024972
59MAP2K60.85843033
60MUSK0.85479270
61DAPK10.85059313
62DMPK0.83337241
63IRAK30.82979999
64RPS6KA40.81498308
65BMPR20.81386135
66MELK0.80802543
67STK160.79889770
68LATS10.79453201
69FER0.77684568
70MAP2K30.76559594
71MAP2K10.75728420
72TRIM280.75322395
73PTK20.74713715
74TRPM70.74654196
75ILK0.73722090
76TESK20.72281685
77BLK0.70384359
78MAP3K10.69130798
79SIK30.68979850
80NME20.67294131
81PKN20.64139191
82CSK0.63953443
83TLK10.63723570
84MAP3K20.62743771
85STK390.62509474
86JAK10.61578459
87PIM10.60271303
88PDPK10.59940402
89MAP3K50.59511398
90MAP4K10.58575928
91AURKB0.56696629
92BRSK10.56564365
93PDGFRA0.56203339
94MATK0.54877366
95PTK60.54310174
96STK380.52245597
97CAMK2D0.52067070
98GSK3A0.49205022
99PRKCI0.48794206
100AURKA0.48657358
101KSR10.48556827
102IRAK40.47764614
103PTK2B0.47672144
104BCR0.47598349
105SCYL20.46918718
106MAPKAPK20.46860003
107JAK30.46575344
108CDK80.46467125
109PAK40.45215268
110MET0.43887482
111ROCK10.43866504
112PAK10.43002721
113TXK0.42759067
114MAP3K120.42284353
115PHKG10.40986347
116PHKG20.40986347
117DAPK30.40832369
118LRRK20.40740949
119ERBB30.40501442
120LYN0.40036457
121NLK0.39988377
122EPHB10.39741321
123CDK90.39492710
124HCK0.38753732
125BMX0.38506886
126FGR0.38262604
127ROCK20.38096723
128OXSR10.37929246
129MAPKAPK50.36976558
130PRKCD0.36922584
131TRIB30.36780392
132ABL10.36739159
133VRK10.36325853
134GRK50.35764089
135ADRBK10.35736204
136NUAK10.35530634
137NEK60.33592438
138NTRK10.33341297
139MAP3K60.33339615
140CAMK2G0.33332513
141PLK10.32433424
142CDK70.31875944
143ZAP700.31268512
144STK240.29240517
145FLT30.27244011
146MAPK110.27222946
147CDK140.23978648
148PRKD20.22878765
149CSNK1G30.22818333
150CDK180.22764722
151SRC0.21945326
152GRK70.21748870

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.81946526
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.18743409
3Mineral absorption_Homo sapiens_hsa049783.03846857
4Leishmaniasis_Homo sapiens_hsa051402.80628457
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.79700321
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.67388843
7Sulfur metabolism_Homo sapiens_hsa009202.67072860
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.65104149
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.57657192
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.50389874
11Pertussis_Homo sapiens_hsa051332.38021317
12Fatty acid elongation_Homo sapiens_hsa000622.19157142
13Influenza A_Homo sapiens_hsa051642.16246445
14Other glycan degradation_Homo sapiens_hsa005112.06513874
15Salmonella infection_Homo sapiens_hsa051322.04887214
16Hepatitis C_Homo sapiens_hsa051601.93010073
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92410950
18Staphylococcus aureus infection_Homo sapiens_hsa051501.92324175
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.91105313
20Malaria_Homo sapiens_hsa051441.89395382
21Legionellosis_Homo sapiens_hsa051341.88199715
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79779373
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.77664708
24Graft-versus-host disease_Homo sapiens_hsa053321.77296546
25Tuberculosis_Homo sapiens_hsa051521.69434818
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68583466
27TNF signaling pathway_Homo sapiens_hsa046681.67609620
28Allograft rejection_Homo sapiens_hsa053301.59624651
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.57587779
30Shigellosis_Homo sapiens_hsa051311.50395348
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50053260
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49428236
33Vibrio cholerae infection_Homo sapiens_hsa051101.48428768
34Toxoplasmosis_Homo sapiens_hsa051451.47211325
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47107737
36Osteoclast differentiation_Homo sapiens_hsa043801.45113743
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41212321
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.41174043
39Sulfur relay system_Homo sapiens_hsa041221.38103141
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37975581
41Starch and sucrose metabolism_Homo sapiens_hsa005001.37208044
42Measles_Homo sapiens_hsa051621.37059386
43N-Glycan biosynthesis_Homo sapiens_hsa005101.36818154
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.35163035
45Asthma_Homo sapiens_hsa053101.32422496
46Nitrogen metabolism_Homo sapiens_hsa009101.30902033
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26629237
48Protein digestion and absorption_Homo sapiens_hsa049741.25178588
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23528604
50Rheumatoid arthritis_Homo sapiens_hsa053231.22495838
51Herpes simplex infection_Homo sapiens_hsa051681.22108870
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.17106253
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17022382
54Antigen processing and presentation_Homo sapiens_hsa046121.15673926
55Lysosome_Homo sapiens_hsa041421.14575458
56Chemical carcinogenesis_Homo sapiens_hsa052041.13599981
57Histidine metabolism_Homo sapiens_hsa003401.12075870
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12017005
59Pyrimidine metabolism_Homo sapiens_hsa002401.09157133
60Biosynthesis of amino acids_Homo sapiens_hsa012301.08896018
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06777630
62Apoptosis_Homo sapiens_hsa042101.06604375
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05926028
64Bile secretion_Homo sapiens_hsa049761.04061158
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.02122020
66Pancreatic cancer_Homo sapiens_hsa052121.01933807
67Hematopoietic cell lineage_Homo sapiens_hsa046400.99412800
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98826331
69Base excision repair_Homo sapiens_hsa034100.96804172
70Arginine biosynthesis_Homo sapiens_hsa002200.95723519
71African trypanosomiasis_Homo sapiens_hsa051430.95093844
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93831396
73Hepatitis B_Homo sapiens_hsa051610.93741230
74Tight junction_Homo sapiens_hsa045300.86444275
75Carbon metabolism_Homo sapiens_hsa012000.86360440
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86292104
77Sphingolipid metabolism_Homo sapiens_hsa006000.84195618
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84139361
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81963665
80PPAR signaling pathway_Homo sapiens_hsa033200.79678965
81Amoebiasis_Homo sapiens_hsa051460.79387912
82Renin-angiotensin system_Homo sapiens_hsa046140.78512262
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78010388
84Retinol metabolism_Homo sapiens_hsa008300.77507358
85Caffeine metabolism_Homo sapiens_hsa002320.76345360
86Pyruvate metabolism_Homo sapiens_hsa006200.76306731
87Fat digestion and absorption_Homo sapiens_hsa049750.75789369
88Type I diabetes mellitus_Homo sapiens_hsa049400.72471688
89Galactose metabolism_Homo sapiens_hsa000520.71799061
90ECM-receptor interaction_Homo sapiens_hsa045120.70856090
91Viral myocarditis_Homo sapiens_hsa054160.70413366
92Vitamin digestion and absorption_Homo sapiens_hsa049770.67799616
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66408798
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65960161
95Bladder cancer_Homo sapiens_hsa052190.65544212
96Alzheimers disease_Homo sapiens_hsa050100.65196159
97Fructose and mannose metabolism_Homo sapiens_hsa000510.64939617
98DNA replication_Homo sapiens_hsa030300.64859575
99Huntingtons disease_Homo sapiens_hsa050160.64828354
100Parkinsons disease_Homo sapiens_hsa050120.62857469
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.61589684
102Proteoglycans in cancer_Homo sapiens_hsa052050.61462386
103Metabolic pathways_Homo sapiens_hsa011000.61080275
104Glutathione metabolism_Homo sapiens_hsa004800.59571327
105Linoleic acid metabolism_Homo sapiens_hsa005910.59181523
106Folate biosynthesis_Homo sapiens_hsa007900.58712861
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57398932
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56725153
109Chronic myeloid leukemia_Homo sapiens_hsa052200.56204951
110Adherens junction_Homo sapiens_hsa045200.56163090
111p53 signaling pathway_Homo sapiens_hsa041150.55968082
112Arginine and proline metabolism_Homo sapiens_hsa003300.55896173
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55658805
114Tyrosine metabolism_Homo sapiens_hsa003500.55658042
115Fatty acid degradation_Homo sapiens_hsa000710.55555564
116Arachidonic acid metabolism_Homo sapiens_hsa005900.53003392
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52523896
118Phagosome_Homo sapiens_hsa041450.52254750
119Focal adhesion_Homo sapiens_hsa045100.48895517
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48304683
121VEGF signaling pathway_Homo sapiens_hsa043700.47914838
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47410379
123Chemokine signaling pathway_Homo sapiens_hsa040620.47233928
124Endocytosis_Homo sapiens_hsa041440.46483260
125Small cell lung cancer_Homo sapiens_hsa052220.46453342
126Nucleotide excision repair_Homo sapiens_hsa034200.45612081
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44324935
128Pentose phosphate pathway_Homo sapiens_hsa000300.44185920
129Complement and coagulation cascades_Homo sapiens_hsa046100.43537438
130Mismatch repair_Homo sapiens_hsa034300.43457785
131Ether lipid metabolism_Homo sapiens_hsa005650.41078040
132Autoimmune thyroid disease_Homo sapiens_hsa053200.40968997
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40901662
134Steroid biosynthesis_Homo sapiens_hsa001000.39996424
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.39767266
136Glycerolipid metabolism_Homo sapiens_hsa005610.39162395
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38952354
138HIF-1 signaling pathway_Homo sapiens_hsa040660.38801286
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38609497
140RNA polymerase_Homo sapiens_hsa030200.38575068
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38447248
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38256130
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38108634
144Pancreatic secretion_Homo sapiens_hsa049720.37796849
145Ovarian steroidogenesis_Homo sapiens_hsa049130.37277140
146Oxidative phosphorylation_Homo sapiens_hsa001900.37057309
147B cell receptor signaling pathway_Homo sapiens_hsa046620.33613895
148Peroxisome_Homo sapiens_hsa041460.32129356
149Phenylalanine metabolism_Homo sapiens_hsa003600.32049584
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31978295
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31480968
152Prolactin signaling pathway_Homo sapiens_hsa049170.30923721

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