TMEM174

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transport (GO:0015893)8.96307264
2organic cation transport (GO:0015695)8.69689733
3lysine metabolic process (GO:0006553)8.54305874
4lysine catabolic process (GO:0006554)8.54305874
5phosphate ion transport (GO:0006817)8.20094149
6glyoxylate metabolic process (GO:0046487)6.99838432
7quaternary ammonium group transport (GO:0015697)6.94709177
8phosphate ion transmembrane transport (GO:0035435)6.78391738
9cysteine metabolic process (GO:0006534)6.75040762
10exogenous drug catabolic process (GO:0042738)6.66944901
11drug catabolic process (GO:0042737)6.65082705
12response to mercury ion (GO:0046689)6.37986942
13tricarboxylic acid metabolic process (GO:0072350)6.11526199
14nonribosomal peptide biosynthetic process (GO:0019184)5.93597502
15excretion (GO:0007588)5.88807101
16aspartate family amino acid catabolic process (GO:0009068)5.73167249
17short-chain fatty acid metabolic process (GO:0046459)5.55527525
18renal absorption (GO:0070293)5.44377992
19vitamin D metabolic process (GO:0042359)5.43474154
20branched-chain amino acid metabolic process (GO:0009081)5.37252941
21glutathione biosynthetic process (GO:0006750)5.31523942
22toxin transport (GO:1901998)5.30957346
23metanephric tubule development (GO:0072170)5.23991375
24metanephric nephron tubule development (GO:0072234)5.23991375
25phosphate ion homeostasis (GO:0055062)5.08571032
26trivalent inorganic anion homeostasis (GO:0072506)5.08571032
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04709162
28amino-acid betaine transport (GO:0015838)5.01775029
29carnitine transport (GO:0015879)5.01775029
30valine metabolic process (GO:0006573)4.98454905
31aromatic amino acid family catabolic process (GO:0009074)4.94849973
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.94550670
33L-phenylalanine metabolic process (GO:0006558)4.94550670
34tryptophan catabolic process (GO:0006569)4.92236710
35indole-containing compound catabolic process (GO:0042436)4.92236710
36indolalkylamine catabolic process (GO:0046218)4.92236710
37homocysteine metabolic process (GO:0050667)4.89268588
38L-phenylalanine catabolic process (GO:0006559)4.86733085
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.86733085
40metanephric nephron epithelium development (GO:0072243)4.81742041
41proline metabolic process (GO:0006560)4.81579887
42serine family amino acid catabolic process (GO:0009071)4.79593500
43cellular modified amino acid catabolic process (GO:0042219)4.77824190
442-oxoglutarate metabolic process (GO:0006103)4.70431876
45modified amino acid transport (GO:0072337)4.69825412
46serine family amino acid metabolic process (GO:0009069)4.69145329
47glycoside metabolic process (GO:0016137)4.67221437
48tryptophan metabolic process (GO:0006568)4.66004307
49amino-acid betaine metabolic process (GO:0006577)4.48885281
50metanephric epithelium development (GO:0072207)4.43049320
51fructose metabolic process (GO:0006000)4.39863939
52fatty acid beta-oxidation (GO:0006635)4.37121440
53branched-chain amino acid catabolic process (GO:0009083)4.33591281
54peptide biosynthetic process (GO:0043043)4.28566700
55nephron tubule development (GO:0072080)4.18182782
56acetyl-CoA metabolic process (GO:0006084)4.15259696
57cellular ketone body metabolic process (GO:0046950)4.13793542
58fatty acid oxidation (GO:0019395)4.07711628
59carnitine metabolic process (GO:0009437)4.07629286
60peptide catabolic process (GO:0043171)4.06795907
61response to phenylpropanoid (GO:0080184)4.05273245
62lipid oxidation (GO:0034440)4.00040743
63glutamate metabolic process (GO:0006536)3.98805054
64oligosaccharide catabolic process (GO:0009313)3.98348855
65serine family amino acid biosynthetic process (GO:0009070)3.89463092
66NADH metabolic process (GO:0006734)3.85755089
67sodium-independent organic anion transport (GO:0043252)3.85528077
68cellular amino acid catabolic process (GO:0009063)3.82055595
69response to parathyroid hormone (GO:0071107)3.76607368
70response to growth hormone (GO:0060416)3.75846405
71indole-containing compound metabolic process (GO:0042430)3.71644623
72vitamin transport (GO:0051180)3.71129963
73renal tubule development (GO:0061326)3.70613768
74kynurenine metabolic process (GO:0070189)3.70612385
75alpha-amino acid catabolic process (GO:1901606)3.69608743
76glutathione metabolic process (GO:0006749)3.68374256
77aromatic amino acid family metabolic process (GO:0009072)3.66082245
78fatty acid catabolic process (GO:0009062)3.60911186
79ketone body metabolic process (GO:1902224)3.56041739
80glutathione derivative biosynthetic process (GO:1901687)3.47337958
81glutathione derivative metabolic process (GO:1901685)3.47337958
82sulfur amino acid catabolic process (GO:0000098)3.47247779
83carboxylic acid catabolic process (GO:0046395)3.46294838
84organic acid catabolic process (GO:0016054)3.46294838
85indolalkylamine metabolic process (GO:0006586)3.45997654
86polyol transport (GO:0015791)3.42210591
87beta-amyloid metabolic process (GO:0050435)3.42066292
88monocarboxylic acid catabolic process (GO:0072329)3.39388490
89nephron epithelium development (GO:0072009)3.38702916
90benzene-containing compound metabolic process (GO:0042537)3.36267988
91drug metabolic process (GO:0017144)3.34361737
92dicarboxylic acid metabolic process (GO:0043648)3.34216017
93nephron epithelium morphogenesis (GO:0072088)3.34137817
94nephron tubule morphogenesis (GO:0072078)3.34137817
95tricarboxylic acid cycle (GO:0006099)3.31837058
96succinate metabolic process (GO:0006105)3.30958693
97biotin metabolic process (GO:0006768)3.30840020
98urate metabolic process (GO:0046415)10.6821322
99aminoglycoside antibiotic metabolic process (GO:0030647)10.6148259
100drug transmembrane transport (GO:0006855)10.5821518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.38007610
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.37051206
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.50942408
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.32867309
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.87832942
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.70549533
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.93589251
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84186309
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.71005013
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.61553610
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57397097
12AR_21909140_ChIP-Seq_LNCAP_Human2.43281418
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.34898823
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.31652070
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.25866921
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.16951083
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.15208116
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07985885
19CLOCK_20551151_ChIP-Seq_293T_Human2.03514179
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99654660
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88017839
22VDR_22108803_ChIP-Seq_LS180_Human1.84008968
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82084593
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77974201
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.74405334
26HNF4A_19822575_ChIP-Seq_HepG2_Human1.66245727
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60731552
28LXR_22292898_ChIP-Seq_THP-1_Human1.55706722
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52574216
30GATA4_25053715_ChIP-Seq_YYC3_Human1.52366713
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48910213
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47165789
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46971925
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.46264540
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39776679
36RACK7_27058665_Chip-Seq_MCF-7_Human1.35519158
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33963726
38EGR1_19032775_ChIP-ChIP_M12_Human1.33540496
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29995851
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.29308769
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19396142
42GATA6_25053715_ChIP-Seq_YYC3_Human1.19374358
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18775946
44SMAD3_21741376_ChIP-Seq_HESCs_Human1.15519226
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.14887300
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.14887300
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10406664
48RXR_22108803_ChIP-Seq_LS180_Human1.07531382
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03910989
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01884303
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.00934310
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97917264
53PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95194683
54SOX2_20726797_ChIP-Seq_SW620_Human0.93485873
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93168421
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92028121
57ERG_21242973_ChIP-ChIP_JURKAT_Human0.91946145
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89427570
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88610963
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88490737
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87368488
62MYC_19915707_ChIP-ChIP_AK7_Human0.86946087
63SMAD4_21741376_ChIP-Seq_HESCs_Human0.86591852
64RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86263297
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85170199
66RAC3_21632823_ChIP-Seq_H3396_Human0.84696992
67GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83854074
68P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82726802
69EP300_21415370_ChIP-Seq_HL-1_Mouse0.82682399
70SMC4_20622854_ChIP-Seq_HELA_Human0.82571894
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81782425
72NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80861415
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79983139
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79517737
75* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78860113
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77165211
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76745110
78MTF2_20144788_ChIP-Seq_MESCs_Mouse0.75022452
79* CDX2_22108803_ChIP-Seq_LS180_Human0.73553848
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73354402
81SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71720358
82CSB_26484114_Chip-Seq_FIBROBLAST_Human0.71526212
83* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71280557
84P68_20966046_ChIP-Seq_HELA_Human0.69755878
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69691154
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69497360
87SOX11_22085726_ChIP-Seq_ESNs_Mouse0.69340670
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69239688
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.68998113
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68320509
91CREB1_26743006_Chip-Seq_LNCaP_Human0.67997312
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67751513
93* TP63_23658742_ChIP-Seq_EP156T_Human0.66924300
94EOMES_21245162_ChIP-Seq_HESCs_Human0.66637648
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66594840
96TP63_22573176_ChIP-Seq_HFKS_Human0.66552564
97VDR_24787735_ChIP-Seq_THP-1_Human0.66210508
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.65571759
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.65518219
100CTCF_27219007_Chip-Seq_Bcells_Human0.64905234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.89832602
2MP0004043_abnormal_pH_regulation6.40272645
3MP0005332_abnormal_amino_acid5.03589706
4MP0004019_abnormal_vitamin_homeostasis5.02489955
5MP0002139_abnormal_hepatobiliary_system4.91516094
6MP0003195_calcinosis4.02360120
7MP0002138_abnormal_hepatobiliary_system4.01082700
8MP0009643_abnormal_urine_homeostasis3.98111991
9MP0001765_abnormal_ion_homeostasis3.84827581
10MP0005636_abnormal_mineral_homeostasis3.16692640
11MP0001756_abnormal_urination3.09354979
12MP0002136_abnormal_kidney_physiology2.95398882
13MP0008875_abnormal_xenobiotic_pharmacok2.94458797
14MP0005377_hearing/vestibular/ear_phenot2.92874117
15MP0003878_abnormal_ear_physiology2.92874117
16MP0001958_emphysema2.67301571
17MP0003252_abnormal_bile_duct2.38006199
18MP0005365_abnormal_bile_salt2.30466029
19MP0005058_abnormal_lysosome_morphology2.17403214
20MP0005085_abnormal_gallbladder_physiolo2.16696100
21MP0003186_abnormal_redox_activity1.77541616
22MP0000538_abnormal_urinary_bladder1.72172123
23MP0008961_abnormal_basal_metabolism1.70547426
24MP0004885_abnormal_endolymph1.70121948
25MP0005584_abnormal_enzyme/coenzyme_acti1.65212087
26MP0005084_abnormal_gallbladder_morpholo1.48340394
27MP0005319_abnormal_enzyme/_coenzyme1.38434583
28MP0002876_abnormal_thyroid_physiology1.38122850
29MP0005451_abnormal_body_composition1.34323329
30MP0003300_gastrointestinal_ulcer1.30329294
31MP0003806_abnormal_nucleotide_metabolis1.29910553
32MP0002928_abnormal_bile_duct1.28947442
33MP0006036_abnormal_mitochondrial_physio1.26007543
34MP0002168_other_aberrant_phenotype1.23193148
35MP0000230_abnormal_systemic_arterial1.18671438
36MP0005670_abnormal_white_adipose1.14407625
37MP0002135_abnormal_kidney_morphology1.09408051
38MP0005535_abnormal_body_temperature1.06348255
39MP0004147_increased_porphyrin_level1.03495533
40MP0002089_abnormal_postnatal_growth/wei1.01962906
41MP0003283_abnormal_digestive_organ1.00523178
42MP0002896_abnormal_bone_mineralization0.99961397
43MP0005666_abnormal_adipose_tissue0.97662988
44MP0001764_abnormal_homeostasis0.97599274
45MP0001666_abnormal_nutrient_absorption0.96829064
46MP0003191_abnormal_cellular_cholesterol0.91294433
47MP0003172_abnormal_lysosome_physiology0.89888990
48MP0002118_abnormal_lipid_homeostasis0.87961591
49MP0003646_muscle_fatigue0.82480398
50MP0004264_abnormal_extraembryonic_tissu0.82375313
51MP0003638_abnormal_response/metabolism_0.80254450
52MP0001661_extended_life_span0.79710724
53MP0009642_abnormal_blood_homeostasis0.75633817
54MP0000747_muscle_weakness0.73132394
55MP0009764_decreased_sensitivity_to0.68644518
56MP0010234_abnormal_vibrissa_follicle0.65946743
57MP0002796_impaired_skin_barrier0.64397283
58MP0005395_other_phenotype0.63843822
59MP0000371_diluted_coat_color0.62543285
60MP0010329_abnormal_lipoprotein_level0.62128645
61MP0005220_abnormal_exocrine_pancreas0.62051851
62MP0000609_abnormal_liver_physiology0.61512209
63MP0001485_abnormal_pinna_reflex0.60559181
64MP0003959_abnormal_lean_body0.59067199
65MP0003879_abnormal_hair_cell0.58873253
66MP0003329_amyloid_beta_deposits0.53689349
67MP0008469_abnormal_protein_level0.53471816
68MP0002115_abnormal_skeleton_extremities0.51837199
69MP0000598_abnormal_liver_morphology0.51430034
70MP0004742_abnormal_vestibular_system0.50226434
71MP0005501_abnormal_skin_physiology0.49938153
72MP0006035_abnormal_mitochondrial_morpho0.48461447
73MP0005408_hypopigmentation0.47888848
74MP0000678_abnormal_parathyroid_gland0.47227379
75MP0003795_abnormal_bone_structure0.46671788
76MP0002078_abnormal_glucose_homeostasis0.46661127
77MP0002998_abnormal_bone_remodeling0.44622717
78MP0005165_increased_susceptibility_to0.44613670
79MP0003953_abnormal_hormone_level0.44349308
80MP0002069_abnormal_eating/drinking_beha0.43791639
81MP0005375_adipose_tissue_phenotype0.39953187
82MP0004858_abnormal_nervous_system0.39717762
83MP0000163_abnormal_cartilage_morphology0.38895668
84MP0010386_abnormal_urinary_bladder0.37611734
85MP0003221_abnormal_cardiomyocyte_apopto0.35710026
86MP0004484_altered_response_of0.35546270
87MP0001663_abnormal_digestive_system0.35201445
88MP0002098_abnormal_vibrissa_morphology0.34947758
89MP0004272_abnormal_basement_membrane0.34035191
90MP0001963_abnormal_hearing_physiology0.33465103
91MP0009672_abnormal_birth_weight0.33376411
92MP0005167_abnormal_blood-brain_barrier0.32929872
93MP0000534_abnormal_ureter_morphology0.32828907
94MP0003724_increased_susceptibility_to0.31108609
95MP0001731_abnormal_postnatal_growth0.30486249
96MP0003315_abnormal_perineum_morphology0.29831535
97MP0001664_abnormal_digestion0.27142643
98MP0009780_abnormal_chondrocyte_physiolo0.26134857
99MP0001177_atelectasis0.25960054
100MP0004233_abnormal_muscle_weight0.25029939

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.63733078
2Metabolic alkalosis (HP:0200114)7.23521145
3Hypokalemic alkalosis (HP:0001949)7.18176409
4Gout (HP:0001997)6.93272853
5Hypomagnesemia (HP:0002917)6.87569860
6Hyperactive renin-angiotensin system (HP:0000841)6.69909713
7Polyuria (HP:0000103)6.53796145
8Abnormality of chloride homeostasis (HP:0011422)6.18508320
9Abnormal urine output (HP:0012590)6.14814183
10Abnormality of renal excretion (HP:0011036)5.88268532
11Abnormality of magnesium homeostasis (HP:0004921)5.82493607
12Proximal tubulopathy (HP:0000114)5.50602321
13Polydipsia (HP:0001959)5.30247344
14Abnormal drinking behavior (HP:0030082)5.30247344
15Hyperuricemia (HP:0002149)5.05125907
16Increased purine levels (HP:0004368)5.05125907
17Hyperglycinuria (HP:0003108)4.77060979
18Tetany (HP:0001281)4.76341973
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.74076785
20Abnormality of renin-angiotensin system (HP:0000847)4.72581182
21Alkalosis (HP:0001948)4.71286793
22Renal salt wasting (HP:0000127)4.68215581
23Hyperaldosteronism (HP:0000859)4.60857988
24Abnormality of purine metabolism (HP:0004352)4.47093719
25Generalized aminoaciduria (HP:0002909)4.17321005
26Hypercalciuria (HP:0002150)4.07741476
27Abnormality of glycine metabolism (HP:0010895)3.92645604
28Abnormality of serine family amino acid metabolism (HP:0010894)3.92645604
29Ketoacidosis (HP:0001993)3.76108865
30Abnormality of urine glucose concentration (HP:0011016)3.69233003
31Glycosuria (HP:0003076)3.69233003
32Renal tubular acidosis (HP:0001947)3.63814146
33Hypokalemia (HP:0002900)3.60925004
34Ketosis (HP:0001946)3.30942822
35Abnormality of nucleobase metabolism (HP:0010932)3.29426669
36Hyperphosphaturia (HP:0003109)3.28466968
37Delayed epiphyseal ossification (HP:0002663)3.14897413
38Abnormal urine phosphate concentration (HP:0012599)3.10547135
39Abnormality of proline metabolism (HP:0010907)3.05830772
40Hydroxyprolinuria (HP:0003080)3.05830772
41Abnormality of potassium homeostasis (HP:0011042)3.03799648
42Nephrocalcinosis (HP:0000121)3.01069457
43Nephrolithiasis (HP:0000787)2.84596806
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.79939213
45Abnormality of fatty-acid metabolism (HP:0004359)2.78811964
46Delayed CNS myelination (HP:0002188)2.75770624
47Hypophosphatemia (HP:0002148)2.73617500
48Hyperglycinemia (HP:0002154)2.70691998
49Vascular calcification (HP:0004934)2.68059019
50Vacuolated lymphocytes (HP:0001922)2.60269047
51Rickets (HP:0002748)2.57954858
52Metaphyseal cupping (HP:0003021)2.57945775
53Widely patent fontanelles and sutures (HP:0004492)2.45798604
54Dehydration (HP:0001944)2.45502503
55Dicarboxylic aciduria (HP:0003215)2.41690622
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41690622
57Hyperammonemia (HP:0001987)2.40543128
58Cardiovascular calcification (HP:0011915)2.39052762
59Abnormality of sodium homeostasis (HP:0010931)2.35995952
60Hyponatremia (HP:0002902)2.32286973
61Metabolic acidosis (HP:0001942)2.30633654
62Vomiting (HP:0002013)2.28616646
63Abnormality of renal resorption (HP:0011038)2.27924325
64Enlarged kidneys (HP:0000105)2.26518735
65Renal tubular dysfunction (HP:0000124)2.23177654
66Abnormal enzyme/coenzyme activity (HP:0012379)2.22698915
67Confusion (HP:0001289)2.22340527
68Malnutrition (HP:0004395)2.18630806
69Abnormality of alkaline phosphatase activity (HP:0004379)2.16443029
70Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15889139
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.11329756
72Adrenal overactivity (HP:0002717)2.10495099
73Thin bony cortex (HP:0002753)2.10268924
74Methylmalonic aciduria (HP:0012120)2.10111051
75Abnormal tarsal ossification (HP:0008369)2.03998837
76Lethargy (HP:0001254)2.03670220
77Bilateral sensorineural hearing impairment (HP:0008619)2.02718239
78Tubular atrophy (HP:0000092)1.94695932
79Facial shape deformation (HP:0011334)1.93789282
80Potter facies (HP:0002009)1.93789282
81Tubulointerstitial fibrosis (HP:0005576)1.91738584
82Chondrocalcinosis (HP:0000934)1.89274644
83Lymphangioma (HP:0100764)1.89198899
84Bicornuate uterus (HP:0000813)1.86007393
85Abnormality of the costochondral junction (HP:0000919)1.82642333
86Nausea (HP:0002018)1.80539679
87Decreased circulating renin level (HP:0003351)1.79919837
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79244415
89Metaphyseal irregularity (HP:0003025)1.79166619
90Irritability (HP:0000737)1.78537621
91Abnormality of Sharpey fibers (HP:0100685)1.77934609
92Sensorimotor neuropathy (HP:0007141)1.75973236
93Elevated alkaline phosphatase (HP:0003155)1.73465123
94Metaphyseal dysplasia (HP:0100255)1.72349304
95Glomerulosclerosis (HP:0000096)1.68672428
96Abnormality of serum amino acid levels (HP:0003112)1.68662253
97Neonatal onset (HP:0003623)1.66704385
98Tachypnea (HP:0002789)1.65202750
99Abnormality of carpal bone ossification (HP:0006257)1.64025145
100Hypotension (HP:0002615)1.62815662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK49.07671823
2WNK38.13372515
3OXSR17.43008671
4STK394.37818819
5BCKDK3.12155528
6STK38L2.59843336
7NEK12.14199749
8PDK42.07996324
9PDK32.07996324
10WNK12.02893717
11SGK2231.87662763
12SGK4941.87662763
13PDK21.48431296
14STK381.39283269
15MST1R1.19261376
16MST41.14916037
17SGK20.99022517
18SGK30.97596099
19LRRK20.96812169
20FGFR40.96665222
21PINK10.90963628
22GRK60.84303966
23EPHB10.78833763
24GSK3A0.73588806
25MAP3K70.64719393
26SGK10.60904914
27DYRK1B0.59067069
28PTK20.56073996
29TIE10.55003442
30MAP3K30.49287986
31PRKAA10.48686150
32PAK40.48252533
33TGFBR20.48244006
34ABL20.47975391
35PDPK10.45112675
36MAPK110.45013998
37ERN10.40415494
38PTK60.40341462
39PRKCI0.37291127
40TRIB30.35897875
41PRKAA20.35101649
42INSRR0.34664855
43PAK30.34045832
44MET0.32398010
45PRKCZ0.31218427
46STK100.31126987
47PRKD20.31061731
48FER0.30858938
49PDK10.30271546
50PTK2B0.29960126
51IRAK20.27091318
52STK110.26304885
53NTRK10.23138718
54NME20.22667118
55PRKCD0.22509623
56MYLK0.21525648
57RIPK10.21085348
58MINK10.19423437
59PRKACG0.19345367
60EPHA40.19293317
61MAP3K140.18910713
62FRK0.18620591
63MAP3K20.16864780
64PRKCH0.16518067
65MAPK150.16280183
66IRAK30.15962755
67LATS10.15300036
68AKT20.15005867
69PRKCA0.13339499
70MAP2K30.13109863
71ERBB40.13098614
72IRAK10.12968415
73BMX0.12370016
74JAK20.11966591
75PRKACA0.11028547
76MAP2K40.10751202
77PIM10.10348171
78MAPK120.07345112
79PRKCG0.06845887
80ROCK10.05970294
81MAP3K110.05451912
82INSR0.05356531
83SCYL20.04907466
84NME10.02885466
85SRC0.02841816
86PRKCQ0.02662648
87MTOR0.00921041
88RPS6KA30.00096850
89CAMK40.00073386
90CAMK1G-0.0424300
91ITK-0.0400590
92ABL1-0.0368362
93DAPK2-0.0299030
94MAPK4-0.0263773
95TAOK1-0.0219789
96PRKD3-0.0197271
97CSNK1A1-0.0093772
98PRKACB-0.0079344
99CSK-0.0067552
100IGF1R-0.0024996

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.88556968
2Butanoate metabolism_Homo sapiens_hsa006503.79031475
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.59783802
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.41975548
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30555362
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.22452497
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.15231943
8Propanoate metabolism_Homo sapiens_hsa006403.09151056
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.92322999
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.83624542
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53396479
12Peroxisome_Homo sapiens_hsa041462.49260139
13Pyruvate metabolism_Homo sapiens_hsa006202.41862965
14Fatty acid degradation_Homo sapiens_hsa000712.30272549
15Tryptophan metabolism_Homo sapiens_hsa003802.23723072
16Collecting duct acid secretion_Homo sapiens_hsa049662.19000305
17Vitamin digestion and absorption_Homo sapiens_hsa049772.07900662
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06471487
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01041346
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97877620
21beta-Alanine metabolism_Homo sapiens_hsa004101.88829693
22Sulfur metabolism_Homo sapiens_hsa009201.77005882
23Fatty acid metabolism_Homo sapiens_hsa012121.73216938
24Carbon metabolism_Homo sapiens_hsa012001.67693424
25Bile secretion_Homo sapiens_hsa049761.62850013
26Glutathione metabolism_Homo sapiens_hsa004801.59020665
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57030055
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56086962
29Arginine and proline metabolism_Homo sapiens_hsa003301.44555253
30Other glycan degradation_Homo sapiens_hsa005111.30909065
31Lysine degradation_Homo sapiens_hsa003101.29869445
32Protein digestion and absorption_Homo sapiens_hsa049741.23883371
33Arginine biosynthesis_Homo sapiens_hsa002201.21921715
34Mineral absorption_Homo sapiens_hsa049781.19201676
35PPAR signaling pathway_Homo sapiens_hsa033201.18541561
36Starch and sucrose metabolism_Homo sapiens_hsa005001.13632955
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.12261325
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12239120
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10398363
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07072454
41Nitrogen metabolism_Homo sapiens_hsa009101.04970153
42Selenocompound metabolism_Homo sapiens_hsa004501.03942443
43Biosynthesis of amino acids_Homo sapiens_hsa012301.01826646
44Histidine metabolism_Homo sapiens_hsa003400.99937677
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98792988
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96585566
47Phenylalanine metabolism_Homo sapiens_hsa003600.90814959
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90119257
49Folate biosynthesis_Homo sapiens_hsa007900.89931886
50Glycerolipid metabolism_Homo sapiens_hsa005610.88204858
51Fructose and mannose metabolism_Homo sapiens_hsa000510.84105970
52Oxidative phosphorylation_Homo sapiens_hsa001900.75021846
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.72320151
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.68096156
55Fatty acid elongation_Homo sapiens_hsa000620.68072660
56Renin-angiotensin system_Homo sapiens_hsa046140.65408452
57Lysosome_Homo sapiens_hsa041420.64850448
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63681891
59Pentose phosphate pathway_Homo sapiens_hsa000300.60510243
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.59635413
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.58231823
62Chemical carcinogenesis_Homo sapiens_hsa052040.57310514
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.55696137
64Metabolic pathways_Homo sapiens_hsa011000.53669579
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53185663
66Thyroid hormone synthesis_Homo sapiens_hsa049180.51569698
67Gastric acid secretion_Homo sapiens_hsa049710.45427861
68Retinol metabolism_Homo sapiens_hsa008300.41649704
69Parkinsons disease_Homo sapiens_hsa050120.41148727
70Vibrio cholerae infection_Homo sapiens_hsa051100.34285856
71Arachidonic acid metabolism_Homo sapiens_hsa005900.33593713
72Synaptic vesicle cycle_Homo sapiens_hsa047210.31186652
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30140065
74Steroid biosynthesis_Homo sapiens_hsa001000.28297065
75Tyrosine metabolism_Homo sapiens_hsa003500.28186727
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27941371
77Sulfur relay system_Homo sapiens_hsa041220.23745271
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21347606
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21213801
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20641385
81ABC transporters_Homo sapiens_hsa020100.19946325
82Choline metabolism in cancer_Homo sapiens_hsa052310.18463254
83Sphingolipid metabolism_Homo sapiens_hsa006000.15234356
84Cardiac muscle contraction_Homo sapiens_hsa042600.14069396
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13677933
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11604129
87Alzheimers disease_Homo sapiens_hsa050100.10890725
88Insulin resistance_Homo sapiens_hsa049310.06086043
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.05684128
90Inositol phosphate metabolism_Homo sapiens_hsa005620.05154449
91Galactose metabolism_Homo sapiens_hsa000520.04404284
92Rheumatoid arthritis_Homo sapiens_hsa053230.04117507
93Huntingtons disease_Homo sapiens_hsa050160.00346766
94AMPK signaling pathway_Homo sapiens_hsa041520.00268732
95Hedgehog signaling pathway_Homo sapiens_hsa04340-0.1001319
96Bladder cancer_Homo sapiens_hsa05219-0.0707548
97One carbon pool by folate_Homo sapiens_hsa00670-0.0477355
98Glucagon signaling pathway_Homo sapiens_hsa04922-0.0461302
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0424175
100alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0304406

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »