TMEM175

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)4.38435653
2negative regulation of cell killing (GO:0031342)4.31796853
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.31796853
4antigen processing and presentation of endogenous antigen (GO:0019883)4.05244784
5neuron cell-cell adhesion (GO:0007158)4.02628269
6ionotropic glutamate receptor signaling pathway (GO:0035235)3.96349065
7neuronal action potential propagation (GO:0019227)3.96285233
8presynaptic membrane assembly (GO:0097105)3.91014797
9protein localization to cilium (GO:0061512)3.89144204
10synaptic vesicle exocytosis (GO:0016079)3.85015294
11glutamate receptor signaling pathway (GO:0007215)3.73380365
12positive regulation of gamma-delta T cell activation (GO:0046645)3.67443085
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66416876
14gamma-aminobutyric acid signaling pathway (GO:0007214)3.62526047
15synaptic transmission, glutamatergic (GO:0035249)3.62124488
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60126104
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.53206367
18negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52229981
19positive thymic T cell selection (GO:0045059)3.49737508
20regulation of neuron projection regeneration (GO:0070570)3.49444176
21regulation of axon regeneration (GO:0048679)3.49444176
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40983682
23postsynaptic membrane organization (GO:0001941)3.40055597
24chaperone-mediated protein transport (GO:0072321)3.39016261
25positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37192493
26presynaptic membrane organization (GO:0097090)3.35515176
27neuron-neuron synaptic transmission (GO:0007270)3.32775591
28energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.30276765
29ATP hydrolysis coupled proton transport (GO:0015991)3.30276765
30regulation of short-term neuronal synaptic plasticity (GO:0048172)3.30124902
31phosphatidylglycerol biosynthetic process (GO:0006655)3.28212740
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27449739
33vocalization behavior (GO:0071625)3.27334351
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.27330197
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27140493
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27082694
37immunoglobulin mediated immune response (GO:0016064)3.24680181
38protein localization to synapse (GO:0035418)3.23417413
39calcium ion-dependent exocytosis (GO:0017156)3.18290045
40neurotransmitter-gated ion channel clustering (GO:0072578)3.17599436
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.17321201
42transmission of nerve impulse (GO:0019226)3.16460874
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15707360
44negative regulation of type 2 immune response (GO:0002829)3.15419831
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.14090570
46NADH dehydrogenase complex assembly (GO:0010257)3.14090570
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14090570
48protein complex biogenesis (GO:0070271)3.09994748
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09758655
50detection of bacterium (GO:0016045)3.09409959
51NIK/NF-kappaB signaling (GO:0038061)3.09113443
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09009674
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06232154
54gamma-aminobutyric acid transport (GO:0015812)3.06109634
55response to histamine (GO:0034776)3.05640913
56negative thymic T cell selection (GO:0045060)3.03047061
57positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.03022379
58respiratory chain complex IV assembly (GO:0008535)3.00797437
59positive regulation by symbiont of host defense response (GO:0052509)3.00358446
60modulation by symbiont of host defense response (GO:0052031)3.00358446
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00358446
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00358446
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.00358446
64modulation by symbiont of host immune response (GO:0052553)3.00358446
65leukocyte aggregation (GO:0070486)2.98576957
66regulation of synaptic transmission, glutamatergic (GO:0051966)2.98357772
67fucose catabolic process (GO:0019317)2.98263104
68L-fucose metabolic process (GO:0042354)2.98263104
69L-fucose catabolic process (GO:0042355)2.98263104
70acrosome reaction (GO:0007340)2.96989604
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95172316
72detection of other organism (GO:0098543)2.94174847
73regulation of glutamate receptor signaling pathway (GO:1900449)2.94158559
74mannosylation (GO:0097502)2.94127106
75thymic T cell selection (GO:0045061)2.93190023
76regulation of T-helper 2 cell differentiation (GO:0045628)2.93130379
77neurotransmitter secretion (GO:0007269)2.92708489
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91968700
79regulation of interferon-beta biosynthetic process (GO:0045357)2.91007128
80regulation of gamma-delta T cell activation (GO:0046643)2.90883646
81macrophage activation involved in immune response (GO:0002281)2.89939247
82positive regulation of membrane potential (GO:0045838)2.89193568
83regulation of vesicle fusion (GO:0031338)2.89050749
84regulation of B cell receptor signaling pathway (GO:0050855)2.88503968
85ATP synthesis coupled proton transport (GO:0015986)2.88426842
86energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88426842
87glutamate secretion (GO:0014047)2.87884428
88negative regulation of erythrocyte differentiation (GO:0045647)2.86063515
89positive regulation of synapse assembly (GO:0051965)2.85570448
90transferrin transport (GO:0033572)2.84871317
91negative regulation of lymphocyte mediated immunity (GO:0002707)2.83225904
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82108760
93negative T cell selection (GO:0043383)2.81660298
94defense response to protozoan (GO:0042832)2.81493348
95neuromuscular process controlling posture (GO:0050884)2.81068257
96regulation of postsynaptic membrane potential (GO:0060078)2.80220408
97actin nucleation (GO:0045010)2.79812313
98regulation of long-term neuronal synaptic plasticity (GO:0048169)2.79123962
99regulation of gamma-delta T cell differentiation (GO:0045586)2.78055474
100activated T cell proliferation (GO:0050798)2.77732337
101regulation of synaptic vesicle exocytosis (GO:2000300)2.77185314
102platelet dense granule organization (GO:0060155)2.75587540
103T cell selection (GO:0045058)2.74935339
104response to muramyl dipeptide (GO:0032495)2.74297451
105synaptic vesicle docking involved in exocytosis (GO:0016081)2.72923659
106startle response (GO:0001964)2.71810696
107neurotransmitter uptake (GO:0001504)2.71338478
108epithelial cilium movement (GO:0003351)2.71001376
109positive T cell selection (GO:0043368)2.70139905
110regulation of type 2 immune response (GO:0002828)2.68868564
111regulation of ARF GTPase activity (GO:0032312)2.68687515
112response to type I interferon (GO:0034340)2.68553581
113cellular response to type I interferon (GO:0071357)2.67847402
114type I interferon signaling pathway (GO:0060337)2.67847402
115respiratory electron transport chain (GO:0022904)2.67515884
116L-serine transport (GO:0015825)2.67147343
117mitochondrial respiratory chain complex assembly (GO:0033108)2.65999490
118proline transport (GO:0015824)2.64754533
119electron transport chain (GO:0022900)2.64387285
120negative regulation of dendrite morphogenesis (GO:0050774)2.64058069
121membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63524158
122exploration behavior (GO:0035640)2.63522933
123neurotransmitter transport (GO:0006836)2.63467234
124long-term synaptic potentiation (GO:0060291)2.63051489
125adult walking behavior (GO:0007628)2.62962135
126regulation of synaptic vesicle transport (GO:1902803)2.62627767
127membrane depolarization (GO:0051899)2.61215450
128neuron recognition (GO:0008038)2.60761007
129regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60532037
130serine transport (GO:0032329)2.59783955
131ferric iron transport (GO:0015682)2.58388349
132trivalent inorganic cation transport (GO:0072512)2.58388349
133serotonin metabolic process (GO:0042428)2.58057647
134neuronal action potential (GO:0019228)2.57864281
135regulation of inositol phosphate biosynthetic process (GO:0010919)2.57138263
136membrane depolarization during action potential (GO:0086010)2.56270304
137negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.56117898
138response to protozoan (GO:0001562)2.55589418
139positive regulation of type 2 immune response (GO:0002830)2.55502255
140germinal center formation (GO:0002467)2.55157622
141cytochrome complex assembly (GO:0017004)2.54753347
142tolerance induction (GO:0002507)2.54270029
143regulation of neurotransmitter levels (GO:0001505)2.52441175
144negative regulation of leukocyte mediated immunity (GO:0002704)2.51985429
145B cell receptor signaling pathway (GO:0050853)2.50958132
146pH reduction (GO:0045851)2.50407487
147locomotory exploration behavior (GO:0035641)2.50216558
148fucosylation (GO:0036065)2.50176009
149phagosome maturation (GO:0090382)2.48968672
150regulation of cilium movement (GO:0003352)2.48901444
151intracellular pH reduction (GO:0051452)2.48652590
152regulation of beta-amyloid formation (GO:1902003)2.48540589
153response to peptidoglycan (GO:0032494)2.48289707
154regulation of neuronal synaptic plasticity (GO:0048168)2.47265705
155glycoside metabolic process (GO:0016137)2.46599242
156negative regulation of neurotransmitter transport (GO:0051589)2.45994856
157interferon-gamma-mediated signaling pathway (GO:0060333)2.44227829
158positive regulation of antigen processing and presentation (GO:0002579)2.41929391
159negative regulation of innate immune response (GO:0045824)2.41407739
160positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.41295307
161cellular response to interleukin-15 (GO:0071350)2.39182416
162regulation of antigen processing and presentation (GO:0002577)2.37856282
163neutrophil activation (GO:0042119)2.37462929
164regulation of T cell mediated cytotoxicity (GO:0001914)2.37005195
165neutrophil activation involved in immune response (GO:0002283)2.34883010
166negative regulation of T-helper cell differentiation (GO:0045623)2.31910226
167negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.31910226
168establishment of mitochondrion localization (GO:0051654)2.30916314
169positive regulation of T cell mediated cytotoxicity (GO:0001916)2.29874764
170response to interleukin-15 (GO:0070672)2.29468501
171detection of external biotic stimulus (GO:0098581)2.27039620
172negative regulation of alpha-beta T cell activation (GO:0046636)2.25078466
173regulation of ARF protein signal transduction (GO:0032012)2.24743053
174regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.24624377
175regulation of natural killer cell mediated immunity (GO:0002715)2.24624377
176regulation of amyloid precursor protein catabolic process (GO:1902991)2.23826555
177positive regulation of Rap GTPase activity (GO:0032854)2.22602498
178positive regulation of CREB transcription factor activity (GO:0032793)2.20227311
179regulation of hydrogen peroxide metabolic process (GO:0010310)2.19567208
180positive regulation of histone deacetylation (GO:0031065)2.17194559
181negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.17075467
182negative regulation of T cell mediated immunity (GO:0002710)2.17041014
183regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.16343951
184granulocyte activation (GO:0036230)2.15295504
185regulation of germinal center formation (GO:0002634)2.14650432
186regulation of B cell differentiation (GO:0045577)2.14507625
187negative regulation of glycoprotein biosynthetic process (GO:0010561)2.14126824
188regulation of mast cell degranulation (GO:0043304)2.13215285
189mitochondrion degradation (GO:0000422)2.10892578
190negative regulation of interleukin-6 production (GO:0032715)2.09680862
191positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.08984799
192neutrophil mediated immunity (GO:0002446)2.08419457
193phagocytosis (GO:0006909)2.07689352
194respiratory burst (GO:0045730)2.07684239
195response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.06320654
196response to host immune response (GO:0052572)2.06320654
197regulation of myeloid leukocyte mediated immunity (GO:0002886)2.05651488

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43047555
2GBX2_23144817_ChIP-Seq_PC3_Human4.70099355
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.70177677
4TAF15_26573619_Chip-Seq_HEK293_Human3.28370857
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.26963638
6IGF1R_20145208_ChIP-Seq_DFB_Human2.93931352
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87133519
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60372878
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53726363
10LXR_22292898_ChIP-Seq_THP-1_Human2.53131058
11VDR_21846776_ChIP-Seq_THP-1_Human2.46003630
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38840374
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.38080696
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35842213
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27928582
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27593999
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27188735
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.25507278
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23249920
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21652498
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19616218
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.17258440
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15703962
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07867330
25AR_21572438_ChIP-Seq_LNCaP_Human2.03730348
26REST_21632747_ChIP-Seq_MESCs_Mouse2.03108013
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01978024
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01292064
29KDM2B_26808549_Chip-Seq_DND41_Human1.98884158
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98827840
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97656332
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97005703
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95749700
34BCL6_27268052_Chip-Seq_Bcells_Human1.95470196
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93056155
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92679576
37P68_20966046_ChIP-Seq_HELA_Human1.91739938
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.88890325
39P300_19829295_ChIP-Seq_ESCs_Human1.87394917
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85929770
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85629600
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.83987444
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81617715
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.79992145
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77007535
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76845634
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76845634
48FUS_26573619_Chip-Seq_HEK293_Human1.75290279
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74493390
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.73870157
51VDR_24763502_ChIP-Seq_THP-1_Human1.72720932
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.71580653
53SMAD4_21799915_ChIP-Seq_A2780_Human1.68451744
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.67712372
55MAF_26560356_Chip-Seq_TH2_Human1.65890398
56BCOR_27268052_Chip-Seq_Bcells_Human1.65179676
57UTX_26944678_Chip-Seq_JUKART_Human1.63224291
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61890038
59* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61195088
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61120287
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.60996274
62ZNF274_21170338_ChIP-Seq_K562_Hela1.60468649
63MYC_22102868_ChIP-Seq_BL_Human1.58991074
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.58989484
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58395212
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.58097731
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.56229408
68TCF7_22412390_ChIP-Seq_EML_Mouse1.55392816
69SMC4_20622854_ChIP-Seq_HELA_Human1.54415234
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54104781
71MAF_26560356_Chip-Seq_TH1_Human1.53951842
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53860922
73* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53335182
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52735959
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.51352986
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.50515480
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50052082
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47428061
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47113658
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46345787
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45842908
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.44689020
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44598750
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43611713
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43124918
86CTCF_27219007_Chip-Seq_Bcells_Human1.42489447
87RUNX_20019798_ChIP-Seq_JUKART_Human1.42338785
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41953293
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.41336801
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.41118645
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.41025247
92KDM2B_26808549_Chip-Seq_K562_Human1.40737596
93ER_23166858_ChIP-Seq_MCF-7_Human1.40085637
94AR_25329375_ChIP-Seq_VCAP_Human1.40050320
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38175435
96DROSHA_22980978_ChIP-Seq_HELA_Human1.37923812
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37700083
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.37237777
99E2F1_20622854_ChIP-Seq_HELA_Human1.36890879
100* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36677931
101EWS_26573619_Chip-Seq_HEK293_Human1.36659297
102SPI1_23127762_ChIP-Seq_K562_Human1.36106264
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35396334
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34662470
105SCL_19346495_ChIP-Seq_HPC-7_Human1.33187640
106VDR_22108803_ChIP-Seq_LS180_Human1.32823677
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32545855
108PHF8_20622854_ChIP-Seq_HELA_Human1.31002515
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.30779665
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28647521
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27754788
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26861693
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25062024
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24423352
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23830929
116EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23758431
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22945778
118OCT4_19829295_ChIP-Seq_ESCs_Human1.22415699
119SA1_27219007_Chip-Seq_Bcells_Human1.22295748
120RNF2_27304074_Chip-Seq_NSC_Mouse1.22050278
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.21373433
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21140187
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20722502
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20473111
125RACK7_27058665_Chip-Seq_MCF-7_Human1.19413053
126ERG_21242973_ChIP-ChIP_JURKAT_Human1.19179068
127RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19036720
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.18873461
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18177053
130RARB_27405468_Chip-Seq_BRAIN_Mouse1.17837753
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.15479406
132SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14873543
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.14613969
134CTCF_20526341_ChIP-Seq_ESCs_Human1.14509906
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14497083
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14069762
137SMAD_19615063_ChIP-ChIP_OVARY_Human1.13973365
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13782140
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13231216
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12671211
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11341666
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11063013
143NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10456352
144KDM2B_26808549_Chip-Seq_REH_Human1.09146076
145RARB_24833708_ChIP-Seq_LIVER_Mouse1.08988101
146PRDM14_20953172_ChIP-Seq_ESCs_Human1.08888818
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08592407
148PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08419428
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08397538
150P53_22387025_ChIP-Seq_ESCs_Mouse1.08152306
151CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08014732
152TCF4_23295773_ChIP-Seq_U87_Human1.05809798
153MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05458832
154CREB1_26743006_Chip-Seq_LNCaP_Human1.05148194
155* TP63_22573176_ChIP-Seq_HFKS_Human1.05056631
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04668520
157RUNX2_22187159_ChIP-Seq_PCA_Human1.04582925
158CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03909079
159MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03301489
160RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03134778
161* JUN_21703547_ChIP-Seq_K562_Human1.02451134
162MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02176383
163SPI1_23547873_ChIP-Seq_NB4_Human1.02090695
164CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02041106
165FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01681336
166IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01194661
167CBP_20019798_ChIP-Seq_JUKART_Human1.01194661
168TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00924798
169ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00275731
170P300_27268052_Chip-Seq_Bcells_Human1.00180040
171SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99806499
172CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99680557
173CMYC_18555785_Chip-Seq_ESCs_Mouse0.99362188
174E2F1_18555785_Chip-Seq_ESCs_Mouse0.98502898
175NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98296699
176ERA_21632823_ChIP-Seq_H3396_Human0.98033959
177EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97413200
178STAT3_18555785_Chip-Seq_ESCs_Mouse0.97277955
179SOX2_21211035_ChIP-Seq_LN229_Gbm0.94867951
180NANOG_19829295_ChIP-Seq_ESCs_Human0.94582939
181SOX2_19829295_ChIP-Seq_ESCs_Human0.94582939
182FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94201582
183SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94179489
184AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94031380
185NMYC_18555785_Chip-Seq_ESCs_Mouse0.91811560
186P300_18555785_Chip-Seq_ESCs_Mouse0.90932713
187RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90799063
188STAT3_23295773_ChIP-Seq_U87_Human0.89900221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.84217910
2MP0004859_abnormal_synaptic_plasticity4.29228309
3MP0002736_abnormal_nociception_after3.42109393
4MP0003436_decreased_susceptibility_to3.42095628
5MP0001968_abnormal_touch/_nociception3.34184681
6MP0003635_abnormal_synaptic_transmissio3.15267104
7MP0003724_increased_susceptibility_to3.12891037
8MP0002735_abnormal_chemical_nociception3.01834029
9MP0009745_abnormal_behavioral_response2.94132375
10MP0009046_muscle_twitch2.85533727
11MP0002064_seizures2.76220919
12MP0002272_abnormal_nervous_system2.48794133
13MP0001835_abnormal_antigen_presentation2.47529071
14MP0002572_abnormal_emotion/affect_behav2.41309025
15MP0003303_peritoneal_inflammation2.40298685
16MP0005671_abnormal_response_to2.39388372
17MP0006276_abnormal_autonomic_nervous2.35319770
18MP0001986_abnormal_taste_sensitivity2.31146545
19MP0002063_abnormal_learning/memory/cond2.29496309
20MP0005058_abnormal_lysosome_morphology2.28970062
21MP0001790_abnormal_immune_system2.25847015
22MP0005387_immune_system_phenotype2.25847015
23MP0001501_abnormal_sleep_pattern2.25290026
24MP0005171_absent_coat_pigmentation2.24160209
25MP0005000_abnormal_immune_tolerance2.24012577
26MP0001800_abnormal_humoral_immune2.20827661
27MP0005025_abnormal_response_to2.17480854
28MP0005410_abnormal_fertilization2.15690524
29MP0001905_abnormal_dopamine_level2.13942141
30MP0004270_analgesia2.11706207
31MP0002419_abnormal_innate_immunity2.04659782
32MP0002734_abnormal_mechanical_nocicepti2.02820063
33MP0009278_abnormal_bone_marrow1.99969766
34MP0001188_hyperpigmentation1.97016321
35MP0002733_abnormal_thermal_nociception1.96200089
36MP0003136_yellow_coat_color1.96117338
37MP0002723_abnormal_immune_serum1.95460011
38MP0002067_abnormal_sensory_capabilities1.95326729
39MP0001529_abnormal_vocalization1.94513787
40MP0001970_abnormal_pain_threshold1.92566913
41MP0000685_abnormal_immune_system1.90054169
42MP0002876_abnormal_thyroid_physiology1.88621550
43MP0001486_abnormal_startle_reflex1.85583968
44MP0001440_abnormal_grooming_behavior1.83882871
45MP0009785_altered_susceptibility_to1.82546759
46MP0002420_abnormal_adaptive_immunity1.79707771
47MP0002452_abnormal_antigen_presenting1.78481618
48MP0001819_abnormal_immune_cell1.78462447
49MP0005423_abnormal_somatic_nervous1.77017844
50MP0004142_abnormal_muscle_tone1.71911772
51MP0001533_abnormal_skeleton_physiology1.70043190
52MP0002653_abnormal_ependyma_morphology1.69590573
53MP0001984_abnormal_olfaction1.62110879
54MP0008569_lethality_at_weaning1.60490449
55MP0001502_abnormal_circadian_rhythm1.58620576
56MP0006082_CNS_inflammation1.54824505
57MP0005379_endocrine/exocrine_gland_phen1.54114741
58MP0002148_abnormal_hypersensitivity_rea1.53891710
59MP0002557_abnormal_social/conspecific_i1.53775860
60MP0003763_abnormal_thymus_physiology1.45734689
61MP0000465_gastrointestinal_hemorrhage1.42634871
62MP0004510_myositis1.41791693
63MP0002822_catalepsy1.38186147
64MP0003329_amyloid_beta_deposits1.37425861
65MP0002405_respiratory_system_inflammati1.37138638
66MP0005174_abnormal_tail_pigmentation1.34972964
67MP0004147_increased_porphyrin_level1.34898456
68MP0002638_abnormal_pupillary_reflex1.33837746
69MP0010155_abnormal_intestine_physiology1.33647665
70MP0000372_irregular_coat_pigmentation1.33050883
71MP0000604_amyloidosis1.31332398
72MP0000716_abnormal_immune_system1.31042005
73MP0002138_abnormal_hepatobiliary_system1.29468415
74MP0002933_joint_inflammation1.27569628
75MP0009780_abnormal_chondrocyte_physiolo1.26857469
76MP0000015_abnormal_ear_pigmentation1.26735198
77MP0005386_behavior/neurological_phenoty1.23484958
78MP0004924_abnormal_behavior1.23484958
79MP0003866_abnormal_defecation1.23370292
80MP0003075_altered_response_to1.23345544
81MP0003191_abnormal_cellular_cholesterol1.21923009
82MP0003183_abnormal_peptide_metabolism1.21752468
83MP0001845_abnormal_inflammatory_respons1.21664515
84MP0004947_skin_inflammation1.19776338
85MP0009379_abnormal_foot_pigmentation1.19068876
86MP0005646_abnormal_pituitary_gland1.18540649
87MP0005645_abnormal_hypothalamus_physiol1.17497551
88MP0002398_abnormal_bone_marrow1.16892580
89MP0008260_abnormal_autophagy1.15807853
90MP0005409_darkened_coat_color1.14534653
91MP0004381_abnormal_hair_follicle1.13929687
92MP0002009_preneoplasia1.11107602
93MP0003633_abnormal_nervous_system1.11002878
94MP0001873_stomach_inflammation1.10818315
95MP0000920_abnormal_myelination1.10670746
96MP0009764_decreased_sensitivity_to1.10630227
97MP0002066_abnormal_motor_capabilities/c1.09871708
98MP0001664_abnormal_digestion1.08937712
99MP0003122_maternal_imprinting1.07069103
100MP0002229_neurodegeneration1.05666217
101MP0008469_abnormal_protein_level1.05160552
102MP0005464_abnormal_platelet_physiology1.03636738
103MP0002184_abnormal_innervation1.02340130
104MP0003631_nervous_system_phenotype1.01767579
105MP0001963_abnormal_hearing_physiology1.01429935
106MP0002882_abnormal_neuron_morphology1.00732594
107MP0009840_abnormal_foam_cell0.99207116
108MP0002163_abnormal_gland_morphology0.98635185
109MP0000689_abnormal_spleen_morphology0.98184560
110MP0004858_abnormal_nervous_system0.97804167
111MP0005397_hematopoietic_system_phenotyp0.97682294
112MP0001545_abnormal_hematopoietic_system0.97682294
113MP0002837_dystrophic_cardiac_calcinosis0.97390915
114MP0003172_abnormal_lysosome_physiology0.93352520
115MP0000955_abnormal_spinal_cord0.92975442
116MP0003300_gastrointestinal_ulcer0.92558928
117MP0000778_abnormal_nervous_system0.92204067
118MP0004215_abnormal_myocardial_fiber0.91560556
119MP0002429_abnormal_blood_cell0.91085645
120MP0003690_abnormal_glial_cell0.89712595
121MP0002909_abnormal_adrenal_gland0.89533927
122MP0003879_abnormal_hair_cell0.87061859
123MP0001765_abnormal_ion_homeostasis0.86988062
124MP0005551_abnormal_eye_electrophysiolog0.86512242
125MP0005167_abnormal_blood-brain_barrier0.86475200
126MP0002722_abnormal_immune_system0.86238273
127MP0005166_decreased_susceptibility_to0.85472420
128MP0003698_abnormal_male_reproductive0.85043994
129MP0004130_abnormal_muscle_cell0.84805394
130MP0005310_abnormal_salivary_gland0.84447099
131MP0005075_abnormal_melanosome_morpholog0.84390558
132MP0004811_abnormal_neuron_physiology0.83593681
133MP0002095_abnormal_skin_pigmentation0.83301509
134MP0008872_abnormal_physiological_respon0.83021264
135MP0008874_decreased_physiological_sensi0.82736231
136MP0000681_abnormal_thyroid_gland0.80700724
137MP0005390_skeleton_phenotype0.78696973
138MP0005535_abnormal_body_temperature0.78537971
139MP0006035_abnormal_mitochondrial_morpho0.78447218
140MP0003632_abnormal_nervous_system0.78224357
141MP0004484_altered_response_of0.77912545
142MP0004885_abnormal_endolymph0.76857443
143MP0003634_abnormal_glial_cell0.76807163
144MP0002998_abnormal_bone_remodeling0.76047877
145MP0009697_abnormal_copulation0.75290978
146MP0009333_abnormal_splenocyte_physiolog0.74621254
147MP0005595_abnormal_vascular_smooth0.73353775
148MP0001958_emphysema0.71537889
149MP0002132_abnormal_respiratory_system0.71125388
150MP0004145_abnormal_muscle_electrophysio0.70895179
151MP0001485_abnormal_pinna_reflex0.70421127
152MP0000678_abnormal_parathyroid_gland0.68912758
153MP0000230_abnormal_systemic_arterial0.68778414
154MP0009384_cardiac_valve_regurgitation0.68143607
155MP0005360_urolithiasis0.67064054
156MP0005365_abnormal_bile_salt0.66415557
157MP0000013_abnormal_adipose_tissue0.65894303
158MP0004883_abnormal_blood_vessel0.65685287
159MP0008004_abnormal_stomach_pH0.65174610
160MP0002069_abnormal_eating/drinking_beha0.64340560
161MP0004742_abnormal_vestibular_system0.63681397
162MP0004043_abnormal_pH_regulation0.63188889
163MP0010386_abnormal_urinary_bladder0.62717715
164MP0003787_abnormal_imprinting0.62379646

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.41034345
2Eczematoid dermatitis (HP:0000976)4.44683030
3Elevated erythrocyte sedimentation rate (HP:0003565)4.34578480
4Atonic seizures (HP:0010819)4.17335692
5Myositis (HP:0100614)3.85926285
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.84595189
7Absent/shortened dynein arms (HP:0200106)3.84595189
8Severe visual impairment (HP:0001141)3.72992672
9Myokymia (HP:0002411)3.68264240
10Epileptic encephalopathy (HP:0200134)3.58636537
11Stomatitis (HP:0010280)3.43205979
12Hepatocellular necrosis (HP:0001404)3.42136283
13Visual hallucinations (HP:0002367)3.41905737
14Hypothermia (HP:0002045)3.39728155
15J-shaped sella turcica (HP:0002680)3.39406525
16Febrile seizures (HP:0002373)3.33453712
17Agammaglobulinemia (HP:0004432)3.28991214
18Mitochondrial inheritance (HP:0001427)3.28671675
19Recurrent abscess formation (HP:0002722)3.26813538
20Abnormal hair whorl (HP:0010721)3.24318308
21Dysostosis multiplex (HP:0000943)3.22067170
22Focal seizures (HP:0007359)3.21724116
23Abnormality of macrophages (HP:0004311)3.21526005
24Acute necrotizing encephalopathy (HP:0006965)3.16746499
25Ankle clonus (HP:0011448)3.15599743
26Recurrent fungal infections (HP:0002841)3.14673811
27Obstructive sleep apnea (HP:0002870)3.13478861
28Recurrent bacterial skin infections (HP:0005406)3.13046581
29Abnormality of polysaccharide metabolism (HP:0011012)3.06648200
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.06648200
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.06648200
32Mediastinal lymphadenopathy (HP:0100721)2.97640514
33Orchitis (HP:0100796)2.96524697
34Obstructive lung disease (HP:0006536)2.96380892
35Chronic obstructive pulmonary disease (HP:0006510)2.96380892
36Meningitis (HP:0001287)2.95518586
37Increased IgE level (HP:0003212)2.94662627
38Gastrointestinal inflammation (HP:0004386)2.91495806
39Abnormal mitochondria in muscle tissue (HP:0008316)2.88651177
40Hyperventilation (HP:0002883)2.88358329
41Inflammation of the large intestine (HP:0002037)2.84520529
42Cellulitis (HP:0100658)2.84305183
43Urinary glycosaminoglycan excretion (HP:0003541)2.83037203
44Mucopolysacchariduria (HP:0008155)2.83037203
45Generalized aminoaciduria (HP:0002909)2.79664238
46Recurrent gram-negative bacterial infections (HP:0005420)2.77798742
47Dialeptic seizures (HP:0011146)2.77335306
48Colitis (HP:0002583)2.76410920
49Medial flaring of the eyebrow (HP:0010747)2.75081848
50Optic neuritis (HP:0100653)2.75044845
51Retrobulbar optic neuritis (HP:0100654)2.75044845
52Progressive macrocephaly (HP:0004481)2.74993865
53Increased CSF lactate (HP:0002490)2.72087433
54Abnormal respiratory epithelium morphology (HP:0012253)2.71039813
55Abnormal respiratory motile cilium morphology (HP:0005938)2.71039813
56Panhypogammaglobulinemia (HP:0003139)2.70522837
57Absence seizures (HP:0002121)2.69315442
58Papilledema (HP:0001085)2.66518671
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.59865910
60Hepatic necrosis (HP:0002605)2.59060587
61Vasculitis (HP:0002633)2.57487080
62Gait imbalance (HP:0002141)2.55659212
63Flat occiput (HP:0005469)2.54380852
64Renal Fanconi syndrome (HP:0001994)2.52572228
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.50263281
66Abnormality of liposaccharide metabolism (HP:0010968)2.48645915
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.48645915
68Abnormality of glycolipid metabolism (HP:0010969)2.48645915
69Congenital primary aphakia (HP:0007707)2.46980157
70Pustule (HP:0200039)2.46761571
71Progressive cerebellar ataxia (HP:0002073)2.44178387
72Nephronophthisis (HP:0000090)2.43694419
73Progressive inability to walk (HP:0002505)2.43366526
74Acute encephalopathy (HP:0006846)2.41020420
75Nonprogressive disorder (HP:0003680)2.40765050
76Nephrogenic diabetes insipidus (HP:0009806)2.40126998
77Polyphagia (HP:0002591)2.39624778
78Increased hepatocellular lipid droplets (HP:0006565)2.38304492
79Generalized tonic-clonic seizures (HP:0002069)2.37181194
80Recurrent cutaneous fungal infections (HP:0011370)2.36756231
81Chronic mucocutaneous candidiasis (HP:0002728)2.36756231
82Prolonged bleeding time (HP:0003010)2.35677104
83Abnormality of renal resorption (HP:0011038)2.34765652
84Clumsiness (HP:0002312)2.33809959
85Gastrointestinal infarctions (HP:0005244)2.33713292
86Broad-based gait (HP:0002136)2.33033712
87Gaze-evoked nystagmus (HP:0000640)2.33001402
88Stridor (HP:0010307)2.32566724
89Pulmonary infiltrates (HP:0002113)2.31431946
90Gingivitis (HP:0000230)2.29940451
91Encephalitis (HP:0002383)2.29785923
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28440956
93Mutism (HP:0002300)2.27738117
94Abnormal drinking behavior (HP:0030082)2.27051465
95Polydipsia (HP:0001959)2.27051465
96Gonadotropin excess (HP:0000837)2.24469146
97Poor suck (HP:0002033)2.23101280
98Type I transferrin isoform profile (HP:0003642)2.21654900
99Abnormal ciliary motility (HP:0012262)2.21501728
100Gastrointestinal stroma tumor (HP:0100723)2.21159557
101Neuronal loss in central nervous system (HP:0002529)2.20617226
102Loss of speech (HP:0002371)2.20470360
103Neurofibrillary tangles (HP:0002185)2.19836825
104Abnormal eating behavior (HP:0100738)2.19803856
105Hemoptysis (HP:0002105)2.19740410
106Pancreatic fibrosis (HP:0100732)2.19301500
107Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17758472
108Joint stiffness (HP:0001387)2.17115919
109Recurrent skin infections (HP:0001581)2.17050649
110Progressive neurologic deterioration (HP:0002344)2.16585526
111Abnormal respiratory motile cilium physiology (HP:0012261)2.15732247
112Inability to walk (HP:0002540)2.15089698
113Abnormality of the columella (HP:0009929)2.14644694
114Abnormality of alanine metabolism (HP:0010916)2.13155488
115Hyperalaninemia (HP:0003348)2.13155488
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13155488
117Systemic lupus erythematosus (HP:0002725)2.12951904
118Purpura (HP:0000979)2.11842297
119Lipid accumulation in hepatocytes (HP:0006561)2.10209761
120Abnormal protein glycosylation (HP:0012346)2.10001351
121Abnormal glycosylation (HP:0012345)2.10001351
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10001351
123Abnormal protein N-linked glycosylation (HP:0012347)2.10001351
124True hermaphroditism (HP:0010459)2.09924076
125Amblyopia (HP:0000646)2.09413750
126Chest pain (HP:0100749)2.09061402
127Neuroendocrine neoplasm (HP:0100634)2.09025983
128Recurrent sinusitis (HP:0011108)2.08575518
129Truncal ataxia (HP:0002078)2.08520388
130Diplopia (HP:0000651)2.08153742
131Abnormality of binocular vision (HP:0011514)2.08153742
132Hypergammaglobulinemia (HP:0010702)2.06922192
133Molar tooth sign on MRI (HP:0002419)2.05610633
134Abnormality of midbrain morphology (HP:0002418)2.05610633
135Methylmalonic acidemia (HP:0002912)2.04559210
136Cerebral palsy (HP:0100021)2.03756425
137Episodic fever (HP:0001954)2.03753301
138Abnormality of calcium-phosphate metabolism (HP:0100530)2.00506530
139Petechiae (HP:0000967)2.00374327
140Patchy hypopigmentation of hair (HP:0011365)1.99889076
141Supranuclear gaze palsy (HP:0000605)1.99617307
142Interstitial pulmonary disease (HP:0006530)1.98872055
143Papilloma (HP:0012740)1.98771957
144Verrucae (HP:0200043)1.98771957
145Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98246971
146Emphysema (HP:0002097)1.97911311
147Lactic acidosis (HP:0003128)1.96598279
148Spontaneous hematomas (HP:0007420)1.94131049
149Restrictive lung disease (HP:0002091)1.93383224
150White forelock (HP:0002211)1.92687261
151Respiratory difficulties (HP:0002880)1.92569602
152Easy fatigability (HP:0003388)1.92434137
153Amyloidosis (HP:0011034)1.91945302
154Autoamputation (HP:0001218)1.90990981
155Sepsis (HP:0100806)1.90396832
156Retinal dysplasia (HP:0007973)1.90329546
157Increased cerebral lipofuscin (HP:0011813)1.90287830
158Microvesicular hepatic steatosis (HP:0001414)1.90230439
159Esotropia (HP:0000565)1.86962394
160Hypoproteinemia (HP:0003075)1.86587184
161Neurodegeneration (HP:0002180)1.86286220
162Spinal canal stenosis (HP:0003416)1.85894378
163Poor coordination (HP:0002370)1.85802483
164Hemiparesis (HP:0001269)1.84870204
165Optic disc pallor (HP:0000543)1.84671221
166Hemorrhage of the eye (HP:0011885)1.84414176
167Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84355267
168Recurrent viral infections (HP:0004429)1.83721099
169Epistaxis (HP:0000421)1.83623964
170Vaginal atresia (HP:0000148)1.83389140
171Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82227349
172Leukocytosis (HP:0001974)1.81833465
173Genital tract atresia (HP:0001827)1.81503663
174Absent speech (HP:0001344)1.81412422
175Dysmetria (HP:0001310)1.81358864
176Hypomagnesemia (HP:0002917)1.81271777
177Urticaria (HP:0001025)1.81158259
178Methylmalonic aciduria (HP:0012120)1.80097920
179Polyuria (HP:0000103)1.80011442
180Increased intramyocellular lipid droplets (HP:0012240)1.79101833
181Reduced antithrombin III activity (HP:0001976)1.78446124
182Blue irides (HP:0000635)1.78384820
183Emotional lability (HP:0000712)1.78096650
184Lymphopenia (HP:0001888)1.77922772
185Global brain atrophy (HP:0002283)1.77135723
186Broad face (HP:0000283)1.76939355
187Hypertensive crisis (HP:0100735)1.75647219
188Granulocytopenia (HP:0001913)1.75023648
189Abnormality of the nasal mucosa (HP:0000433)1.74836743
190Growth hormone excess (HP:0000845)1.74617908
191Cervical subluxation (HP:0003308)1.73649393
192Progressive microcephaly (HP:0000253)1.70155909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.95124678
2TNIK3.68893647
3CASK3.64539884
4EPHA43.45609061
5NTRK33.36794953
6MAP4K13.30704672
7MAP2K73.01977087
8ERN12.82109202
9CDK192.75281425
10MAP3K132.43204745
11MAP3K112.23234979
12MUSK2.17904366
13MAP3K42.13757316
14PRKD32.08967815
15GRK62.06387620
16BLK1.98174831
17CAMKK21.97472154
18MAPK131.93185209
19MAPKAPK51.85339119
20RIPK41.85021287
21SIK31.80278155
22TBK11.80095889
23ARAF1.79599413
24STK161.78374588
25TAOK11.78035565
26EPHB11.77228560
27OXSR11.76362360
28PRPF4B1.74457920
29SIK11.74156942
30TESK21.66538526
31ZAP701.64353958
32TYK21.64151725
33CCNB11.54613558
34TXK1.53129142
35MAP2K41.49576974
36MINK11.46966795
37TRIB31.46864133
38IKBKE1.46725837
39BCKDK1.40842067
40MAP2K31.37185807
41STK391.35963049
42MAP3K91.33735065
43TESK11.33144081
44DAPK11.31412446
45MAP3K61.30090697
46FES1.28798046
47ADRBK21.24570273
48NME11.23469853
49BMPR21.21651706
50MAPK151.20403345
51BTK1.19835618
52HIPK21.19385918
53DAPK21.17555506
54KIT1.16527224
55CDK81.14644443
56GRK51.13852837
57TAOK31.12112616
58BRAF1.08916910
59CSK1.08448381
60NTRK21.07982659
61EPHA31.07331860
62CAMK2A1.06648764
63CSF1R1.05101172
64JAK31.04762606
65MYLK1.04434404
66PTK2B1.01961762
67CAMK2B0.97505975
68PAK60.96714114
69HCK0.94440218
70PRKCG0.94092561
71PRKD20.93022361
72CDK30.92866677
73GRK70.92213314
74MAP4K20.89062237
75DYRK1B0.88796713
76RPS6KA20.88685425
77ITK0.88578625
78NTRK10.87963087
79PNCK0.87373040
80CAMK10.86202024
81JAK10.85108911
82LCK0.84504804
83CDC42BPA0.84148812
84FLT30.81967931
85BMPR1B0.81877279
86KSR20.79726472
87MAP3K30.77719495
88PDK10.76570414
89MATK0.76503463
90PDK30.76481303
91PDK40.76481303
92PLK20.75607088
93MAPK70.75542115
94PIM20.74553976
95CDK50.73622268
96JAK20.73462808
97WNK40.72671395
98WNK30.72143884
99RAF10.70652284
100STK380.70318074
101IKBKB0.69481979
102PDPK10.68822068
103MAP2K60.66951461
104BRSK20.65900287
105IRAK10.65794639
106KDR0.64493573
107PHKG20.64113188
108PHKG10.64113188
109NEK60.63008879
110FYN0.62785829
111PRKD10.62622139
112RPS6KC10.62127777
113RPS6KL10.62127777
114SGK4940.61949451
115SGK2230.61949451
116PRKCE0.61880105
117MARK30.61877721
118MAP3K70.60600531
119BCR0.60436141
120TNK20.58086279
121UHMK10.57899074
122RPS6KA60.57818127
123PRKCH0.57682976
124SGK20.56423950
125CAMK2D0.55011601
126MAP2K20.54957992
127CDK180.54626908
128PINK10.54507479
129DYRK1A0.52922431
130IRAK20.52839250
131PRKCZ0.52520174
132CDK150.51403913
133CAMK2G0.51278305
134TEC0.51049990
135ADRBK10.49417731
136CDK11A0.48943871
137SIK20.48916086
138MAPK40.48223598
139SYK0.47684708
140MARK20.47539234
141CDK140.46448306
142TAOK20.46352340
143MARK10.44636922
144CAMKK10.44328335
145PKN10.43414847
146MAP3K140.42965503
147PTK60.42660705
148BRD40.41598845
149CSNK1G20.41280194
150IRAK40.40774750
151TLK10.40688776
152PRKCQ0.40187858
153PRKG20.40183078
154MAP3K10.39203210
155MAPK120.39007989
156CHUK0.38920627
157MST40.38374991
158PKN20.38301792
159FGR0.37259812
160LYN0.36898533
161CAMK40.35158258
162PRKACA0.34552511
163CSNK1G30.33979866

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.21016009
2Oxidative phosphorylation_Homo sapiens_hsa001903.28219825
3Collecting duct acid secretion_Homo sapiens_hsa049662.84330610
4Synaptic vesicle cycle_Homo sapiens_hsa047212.76270782
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69113235
6Primary immunodeficiency_Homo sapiens_hsa053402.47431063
7Morphine addiction_Homo sapiens_hsa050322.44489477
8Parkinsons disease_Homo sapiens_hsa050122.43639022
9GABAergic synapse_Homo sapiens_hsa047272.40636678
10Glutamatergic synapse_Homo sapiens_hsa047242.39489589
11Olfactory transduction_Homo sapiens_hsa047402.21632514
12Circadian entrainment_Homo sapiens_hsa047132.21412776
13Long-term potentiation_Homo sapiens_hsa047202.15683553
14Alzheimers disease_Homo sapiens_hsa050102.15519088
15Allograft rejection_Homo sapiens_hsa053302.10230807
16Amphetamine addiction_Homo sapiens_hsa050312.01277686
17Osteoclast differentiation_Homo sapiens_hsa043801.96181115
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.95818123
19Graft-versus-host disease_Homo sapiens_hsa053321.95520201
20Taste transduction_Homo sapiens_hsa047421.93694313
21Serotonergic synapse_Homo sapiens_hsa047261.90979486
22Autoimmune thyroid disease_Homo sapiens_hsa053201.88967746
23Staphylococcus aureus infection_Homo sapiens_hsa051501.84488394
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82414330
25Leishmaniasis_Homo sapiens_hsa051401.77772522
26Vibrio cholerae infection_Homo sapiens_hsa051101.76579057
27Huntingtons disease_Homo sapiens_hsa050161.75681125
28Calcium signaling pathway_Homo sapiens_hsa040201.69357397
29Salivary secretion_Homo sapiens_hsa049701.61115855
30Protein export_Homo sapiens_hsa030601.59220516
31B cell receptor signaling pathway_Homo sapiens_hsa046621.56683138
32Dopaminergic synapse_Homo sapiens_hsa047281.56160991
33Long-term depression_Homo sapiens_hsa047301.54487426
34Insulin secretion_Homo sapiens_hsa049111.50715135
35Tuberculosis_Homo sapiens_hsa051521.49875296
36Cardiac muscle contraction_Homo sapiens_hsa042601.46908060
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46627449
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42989716
39Asthma_Homo sapiens_hsa053101.40556564
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39516217
41Renin secretion_Homo sapiens_hsa049241.37249282
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32299557
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32008261
44Cocaine addiction_Homo sapiens_hsa050301.26072337
45Hematopoietic cell lineage_Homo sapiens_hsa046401.25811091
46Gastric acid secretion_Homo sapiens_hsa049711.25556850
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20863222
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16462436
49Antigen processing and presentation_Homo sapiens_hsa046121.16448911
50Sphingolipid metabolism_Homo sapiens_hsa006001.16342846
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16003634
52Cholinergic synapse_Homo sapiens_hsa047251.14996550
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14730946
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13281247
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10633049
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09531159
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.07977762
58T cell receptor signaling pathway_Homo sapiens_hsa046601.06088665
59Chemokine signaling pathway_Homo sapiens_hsa040621.04808299
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04148446
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03608045
62Notch signaling pathway_Homo sapiens_hsa043301.03515685
63Other glycan degradation_Homo sapiens_hsa005111.02600228
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01423926
65Toxoplasmosis_Homo sapiens_hsa051451.01346471
66Pertussis_Homo sapiens_hsa051331.00243698
67Viral myocarditis_Homo sapiens_hsa054160.99337570
68Oxytocin signaling pathway_Homo sapiens_hsa049210.99234755
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99203217
70Acute myeloid leukemia_Homo sapiens_hsa052210.99076849
71Rheumatoid arthritis_Homo sapiens_hsa053230.98010742
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94643938
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94009657
74N-Glycan biosynthesis_Homo sapiens_hsa005100.93224437
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92821989
76Endocytosis_Homo sapiens_hsa041440.89787115
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89224477
78VEGF signaling pathway_Homo sapiens_hsa043700.88822208
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.88753721
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87878420
81cAMP signaling pathway_Homo sapiens_hsa040240.87785500
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87253731
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.86746253
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83412995
85Regulation of autophagy_Homo sapiens_hsa041400.81634102
86Malaria_Homo sapiens_hsa051440.81569286
87Steroid biosynthesis_Homo sapiens_hsa001000.81134694
88Influenza A_Homo sapiens_hsa051640.80791621
89Ether lipid metabolism_Homo sapiens_hsa005650.80688558
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80368023
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.80154282
92TNF signaling pathway_Homo sapiens_hsa046680.80073664
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78989334
94ABC transporters_Homo sapiens_hsa020100.78567220
95Pancreatic secretion_Homo sapiens_hsa049720.76225081
96Fatty acid elongation_Homo sapiens_hsa000620.76117650
97GnRH signaling pathway_Homo sapiens_hsa049120.75950767
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74223927
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73597386
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.72649872
101Salmonella infection_Homo sapiens_hsa051320.71600685
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71438322
103Herpes simplex infection_Homo sapiens_hsa051680.71266280
104Platelet activation_Homo sapiens_hsa046110.70771355
105Gap junction_Homo sapiens_hsa045400.67818631
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.66688178
107Measles_Homo sapiens_hsa051620.66162224
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65700167
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.64732128
110Hepatitis C_Homo sapiens_hsa051600.64067597
111Type II diabetes mellitus_Homo sapiens_hsa049300.63020786
112Phagosome_Homo sapiens_hsa041450.61981993
113Choline metabolism in cancer_Homo sapiens_hsa052310.61764387
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57604463
115Pyruvate metabolism_Homo sapiens_hsa006200.57251140
116Sulfur metabolism_Homo sapiens_hsa009200.56047880
117Lysosome_Homo sapiens_hsa041420.54981525
118Proteasome_Homo sapiens_hsa030500.54944906
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54564747
120Ribosome_Homo sapiens_hsa030100.53974117
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53181785
122Circadian rhythm_Homo sapiens_hsa047100.52935760
123Prolactin signaling pathway_Homo sapiens_hsa049170.52450186
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52323394
125Linoleic acid metabolism_Homo sapiens_hsa005910.52177264
126Inositol phosphate metabolism_Homo sapiens_hsa005620.52172122
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.51566527
128Purine metabolism_Homo sapiens_hsa002300.50315403
129mTOR signaling pathway_Homo sapiens_hsa041500.49722199
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48531886
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47637404
132Ovarian steroidogenesis_Homo sapiens_hsa049130.47339403
133Oocyte meiosis_Homo sapiens_hsa041140.46106137
134Type I diabetes mellitus_Homo sapiens_hsa049400.43625671
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43066897
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42910645
137Arachidonic acid metabolism_Homo sapiens_hsa005900.40518361
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.38970953
139Metabolic pathways_Homo sapiens_hsa011000.38945271
140Ras signaling pathway_Homo sapiens_hsa040140.38729656
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38688853
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.38529987
143Phototransduction_Homo sapiens_hsa047440.37478334
144African trypanosomiasis_Homo sapiens_hsa051430.35479803
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.34518201
146Melanogenesis_Homo sapiens_hsa049160.32182785
147RNA polymerase_Homo sapiens_hsa030200.31932374
148Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29791784
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28472548
150MAPK signaling pathway_Homo sapiens_hsa040100.26707717
151Axon guidance_Homo sapiens_hsa043600.24848713
152Shigellosis_Homo sapiens_hsa051310.24079036
153Thyroid hormone synthesis_Homo sapiens_hsa049180.23417901
154Fructose and mannose metabolism_Homo sapiens_hsa000510.22806910

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