TMEM176B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)5.81447480
2antigen processing and presentation of endogenous antigen (GO:0019883)4.93925925
3regulation of fibrinolysis (GO:0051917)4.78594097
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.61758009
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.61758009
6regulation of protein activation cascade (GO:2000257)4.58909210
7exogenous drug catabolic process (GO:0042738)4.57481690
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55335081
9phenylpropanoid metabolic process (GO:0009698)4.43867658
10regulation of complement activation (GO:0030449)4.43516491
11omega-hydroxylase P450 pathway (GO:0097267)4.13978873
12antigen processing and presentation via MHC class Ib (GO:0002475)4.07167771
13drug metabolic process (GO:0017144)4.06344512
14complement activation (GO:0006956)4.04660951
15negative regulation of protein activation cascade (GO:2000258)3.98613987
16negative regulation of complement activation (GO:0045916)3.98200259
17response to interferon-beta (GO:0035456)3.87171919
18protein activation cascade (GO:0072376)3.84246843
19urate metabolic process (GO:0046415)3.80888470
20valine metabolic process (GO:0006573)3.75016781
21drug transmembrane transport (GO:0006855)3.68939758
22nitrogen cycle metabolic process (GO:0071941)3.66570560
23cellular glucuronidation (GO:0052695)3.60760159
24regulation of triglyceride catabolic process (GO:0010896)3.56847896
25negative regulation of fibrinolysis (GO:0051918)3.56006203
26angiotensin maturation (GO:0002003)3.52570450
27glucuronate metabolic process (GO:0019585)3.51256474
28uronic acid metabolic process (GO:0006063)3.51256474
29L-phenylalanine metabolic process (GO:0006558)3.50901398
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.50901398
31L-phenylalanine catabolic process (GO:0006559)3.49672850
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.49672850
33ethanol metabolic process (GO:0006067)3.49319506
34fat-soluble vitamin biosynthetic process (GO:0042362)3.48766297
35phospholipid efflux (GO:0033700)3.46287985
36fibrinolysis (GO:0042730)3.37881748
37peptide catabolic process (GO:0043171)3.35619855
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.33502750
39aromatic amino acid family catabolic process (GO:0009074)3.33341541
40drug transport (GO:0015893)3.32982945
41response to interferon-alpha (GO:0035455)3.32697265
42plasma lipoprotein particle remodeling (GO:0034369)3.32667318
43protein-lipid complex remodeling (GO:0034368)3.32667318
44macromolecular complex remodeling (GO:0034367)3.32667318
45bile acid metabolic process (GO:0008206)3.31771523
46glyoxylate metabolic process (GO:0046487)3.30286558
47negative regulation of humoral immune response (GO:0002921)3.27398457
48blood coagulation, intrinsic pathway (GO:0007597)3.26152207
49positive regulation of triglyceride lipase activity (GO:0061365)3.25304341
50positive regulation of lipoprotein lipase activity (GO:0051006)3.25304341
51triglyceride homeostasis (GO:0070328)3.24775068
52acylglycerol homeostasis (GO:0055090)3.24775068
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23610247
54aminoglycoside antibiotic metabolic process (GO:0030647)3.23109614
55cholesterol efflux (GO:0033344)3.22890938
56peptide hormone processing (GO:0016486)3.20726610
57tryptophan catabolic process (GO:0006569)3.20012594
58indole-containing compound catabolic process (GO:0042436)3.20012594
59indolalkylamine catabolic process (GO:0046218)3.20012594
60toxin transport (GO:1901998)3.19130851
61ribosomal small subunit assembly (GO:0000028)3.18741599
62high-density lipoprotein particle remodeling (GO:0034375)3.17961250
63sulfur amino acid catabolic process (GO:0000098)3.14823341
64regulation of natural killer cell differentiation (GO:0032823)3.14133731
65bile acid and bile salt transport (GO:0015721)3.14000009
66negative regulation of cholesterol transport (GO:0032375)3.13942729
67negative regulation of sterol transport (GO:0032372)3.13942729
68tryptophan metabolic process (GO:0006568)3.11580737
69regulation of extracellular matrix disassembly (GO:0010715)3.11129751
70endosome to pigment granule transport (GO:0043485)3.08928710
71endosome to melanosome transport (GO:0035646)3.08928710
72positive regulation of natural killer cell differentiation (GO:0032825)3.07732013
73arginine metabolic process (GO:0006525)3.05251294
74platelet dense granule organization (GO:0060155)3.02827158
75cysteine metabolic process (GO:0006534)3.01165963
76negative regulation of erythrocyte differentiation (GO:0045647)2.99470901
77alkaloid metabolic process (GO:0009820)2.98966706
78cellular ketone body metabolic process (GO:0046950)2.97850825
79surfactant homeostasis (GO:0043129)2.97246163
80tricarboxylic acid metabolic process (GO:0072350)2.96446491
81glycosphingolipid catabolic process (GO:0046479)2.95716859
82negative regulation of hemostasis (GO:1900047)2.93132935
83negative regulation of blood coagulation (GO:0030195)2.93132935
84signal peptide processing (GO:0006465)2.91880288
85definitive hemopoiesis (GO:0060216)2.91155254
86oligosaccharide catabolic process (GO:0009313)2.90646652
87oxidative demethylation (GO:0070989)2.90574196
88regulation of humoral immune response (GO:0002920)2.89207717
89positive regulation of antigen processing and presentation (GO:0002579)2.88069684
90hormone catabolic process (GO:0042447)2.84363540
91branched-chain amino acid metabolic process (GO:0009081)2.82876841
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80745613
93eosinophil chemotaxis (GO:0048245)2.79630342
94regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.79622638
95nitric oxide biosynthetic process (GO:0006809)2.77622894
96negative regulation of coagulation (GO:0050819)2.76907932
97regulation of bile acid biosynthetic process (GO:0070857)2.75607286
98glycolipid catabolic process (GO:0019377)2.75218333
99vitamin D metabolic process (GO:0042359)2.74038452
100positive regulation of T cell mediated cytotoxicity (GO:0001916)2.73710944
101heme transport (GO:0015886)2.73071179
102sphingolipid catabolic process (GO:0030149)2.72643362
103renal absorption (GO:0070293)2.71851049
104ethanol oxidation (GO:0006069)2.68596472
105response to type I interferon (GO:0034340)2.66902956
106cellular response to type I interferon (GO:0071357)2.65732027
107type I interferon signaling pathway (GO:0060337)2.65732027
108negative regulation of wound healing (GO:0061045)2.64835600
109S-adenosylmethionine metabolic process (GO:0046500)2.64185222
110bile acid biosynthetic process (GO:0006699)2.62885699
111intestinal absorption (GO:0050892)2.61714357
112imidazole-containing compound metabolic process (GO:0052803)2.61388860
113mature B cell differentiation involved in immune response (GO:0002313)2.61287128
114response to thyroid hormone (GO:0097066)2.60807418
115xenobiotic catabolic process (GO:0042178)2.60606305
116positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.60243491
117membrane lipid catabolic process (GO:0046466)2.59393039
118plasma lipoprotein particle organization (GO:0071827)2.58722764
119kynurenine metabolic process (GO:0070189)2.57823327
120NIK/NF-kappaB signaling (GO:0038061)2.57724103
121acute inflammatory response (GO:0002526)2.57638178
122ketone body metabolic process (GO:1902224)2.56573640
123adhesion of symbiont to host cell (GO:0044650)2.56268956
124virion attachment to host cell (GO:0019062)2.56268956
125positive regulation of lipid catabolic process (GO:0050996)2.55456474
126complement activation, alternative pathway (GO:0006957)2.55256980
127amino-acid betaine metabolic process (GO:0006577)2.54975238
128L-alpha-amino acid transmembrane transport (GO:1902475)2.54914047
129lysine catabolic process (GO:0006554)2.54805690
130lysine metabolic process (GO:0006553)2.54805690
131positive regulation of fatty acid biosynthetic process (GO:0045723)2.54439561
132organic cation transport (GO:0015695)2.54095212
133primary alcohol metabolic process (GO:0034308)2.52404327
134macroautophagy (GO:0016236)2.52271533
135regulation of lipoprotein particle clearance (GO:0010984)2.51285983
136alpha-linolenic acid metabolic process (GO:0036109)2.50476062
137myeloid dendritic cell differentiation (GO:0043011)2.50438469
138response to nitrosative stress (GO:0051409)2.50149059
139benzene-containing compound metabolic process (GO:0042537)2.50084941
140T-helper 1 type immune response (GO:0042088)2.49494775
141regulation of natural killer cell activation (GO:0032814)2.48270032
142regulation of antigen processing and presentation (GO:0002577)2.47757788
143positive regulation of respiratory burst (GO:0060267)2.45832911
144phospholipid scrambling (GO:0017121)2.45762882
145dendritic cell differentiation (GO:0097028)2.45289896
146fatty acid oxidation (GO:0019395)2.43710215
147fatty acid beta-oxidation (GO:0006635)2.43684018
148flavonoid metabolic process (GO:0009812)2.42791730
149positive regulation of natural killer cell activation (GO:0032816)2.41972560
150branched-chain amino acid catabolic process (GO:0009083)2.41310074
151regulation of cholesterol esterification (GO:0010872)2.40520986
152lipid oxidation (GO:0034440)2.40405485
153myeloid dendritic cell activation (GO:0001773)2.40312221
154NAD biosynthetic process (GO:0009435)2.38218298
155aromatic amino acid family metabolic process (GO:0009072)2.34453055
156primary alcohol catabolic process (GO:0034310)2.34345736
157low-density lipoprotein particle remodeling (GO:0034374)2.34228984
158nicotinamide nucleotide biosynthetic process (GO:0019359)2.33709059
159pyridine nucleotide biosynthetic process (GO:0019363)2.33709059
160detection of other organism (GO:0098543)2.32175115
161protein carboxylation (GO:0018214)2.30699055
162peptidyl-glutamic acid carboxylation (GO:0017187)2.30699055
1632-oxoglutarate metabolic process (GO:0006103)2.30655396
164acute-phase response (GO:0006953)2.30551858
165complement activation, classical pathway (GO:0006958)2.30101559
166drug catabolic process (GO:0042737)2.30069622
167secretory granule organization (GO:0033363)2.29876868
168positive regulation of glycoprotein biosynthetic process (GO:0010560)2.29371404
169regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.28303820
170glycoside metabolic process (GO:0016137)2.27855898
171carnitine metabolic process (GO:0009437)2.27725493
172reverse cholesterol transport (GO:0043691)2.27170812
173urea cycle (GO:0000050)2.26039167
174urea metabolic process (GO:0019627)2.26039167
175growth hormone receptor signaling pathway (GO:0060396)2.25772832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.49125660
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.79226145
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.09913145
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.09616977
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.61368106
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.59338845
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.41507182
8SCL_19346495_ChIP-Seq_HPC-7_Human3.12249715
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.04726770
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.02215294
11LXR_22158963_ChIP-Seq_LIVER_Mouse3.00897912
12GATA1_22025678_ChIP-Seq_K562_Human2.93754791
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81603818
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.68508494
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.56714135
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.53201216
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.49187853
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.41312510
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19707540
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.19419832
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.15169467
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.13899526
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.12073808
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.11697094
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11258130
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10915655
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95251939
28* IRF8_27001747_Chip-Seq_BMDM_Mouse1.90038877
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89590726
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89502148
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.87718083
32CLOCK_20551151_ChIP-Seq_293T_Human1.84549320
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76051749
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75673536
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72627292
36GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.71799685
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69976952
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67424206
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67150947
40* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62567490
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59728039
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57106528
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52036668
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.50687766
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50226469
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48394395
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48280454
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46090459
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43792187
50VDR_24763502_ChIP-Seq_THP-1_Human1.38205411
51SOX2_20726797_ChIP-Seq_SW620_Human1.37770761
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.37379673
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36726860
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36304800
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.34564985
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34383313
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32897621
58HTT_18923047_ChIP-ChIP_STHdh_Human1.32063542
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30667047
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29830310
61SPI1_23547873_ChIP-Seq_NB4_Human1.25330147
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24655067
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23580001
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.22711589
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.22328073
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20304870
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19949592
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19518206
69MYB_26560356_Chip-Seq_TH2_Human1.18451314
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.17107012
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16914828
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.16842873
73MAF_26560356_Chip-Seq_TH1_Human1.16684104
74HNF4A_19822575_ChIP-Seq_HepG2_Human1.16297918
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13785135
76AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13105122
77VDR_21846776_ChIP-Seq_THP-1_Human1.10851526
78RUNX_20019798_ChIP-Seq_JUKART_Human1.10607298
79GATA4_25053715_ChIP-Seq_YYC3_Human1.10260317
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09062949
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08550566
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06414121
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05601092
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04336777
85MYB_26560356_Chip-Seq_TH1_Human1.03285530
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01059839
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.00222661
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99561528
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97573809
90LXR_22292898_ChIP-Seq_THP-1_Human0.96469163
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.95810310
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95103977
93P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94408457
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94395348
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.94127808
96GATA2_19941826_ChIP-Seq_K562_Human0.91085097
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91044554
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90021495
99SPI1_23127762_ChIP-Seq_K562_Human0.89871804
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89751909
101BCAT_22108803_ChIP-Seq_LS180_Human0.89630852
102TCF7_22412390_ChIP-Seq_EML_Mouse0.89482319
103GATA1_19941826_ChIP-Seq_K562_Human0.89461594
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88855420
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88717623
106FOXA1_25552417_ChIP-Seq_VCAP_Human0.88556360
107* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88292000
108VDR_24787735_ChIP-Seq_THP-1_Human0.88195838
109PU_27001747_Chip-Seq_BMDM_Mouse0.86353601
110GATA6_25053715_ChIP-Seq_YYC3_Human0.86072849
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.85635152
112STAT1_20625510_ChIP-Seq_HELA_Human0.85271215
113FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85101485
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85096386
115CDX2_22108803_ChIP-Seq_LS180_Human0.84780802
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83805933
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81484561
118EGR1_19032775_ChIP-ChIP_M12_Human0.80868840
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80439017
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80080688
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80012150
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79857048
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79834891
124AR_20517297_ChIP-Seq_VCAP_Human0.78906518
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77655449
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77591758
127EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75645526
128TAF2_19829295_ChIP-Seq_ESCs_Human0.73309013
129MYC_19829295_ChIP-Seq_ESCs_Human0.73083949
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.71869426
131* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71839608
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71806901
133FOXA1_21572438_ChIP-Seq_LNCaP_Human0.70412252
134HNFA_21074721_ChIP-Seq_CACO-2_Human0.70383096
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69670104
136GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.69245768
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69245519
138* BCOR_27268052_Chip-Seq_Bcells_Human0.67345327
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66710221
140CBP_21632823_ChIP-Seq_H3396_Human0.66010038
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65380115
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.64939258
143CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.64683661
144PU1_27457419_Chip-Seq_LIVER_Mouse0.63415858
145GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.63056662
146NFYA_21822215_ChIP-Seq_K562_Human0.62906556
147SA1_27219007_Chip-Seq_Bcells_Human0.62855937
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.62766387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.53316699
2MP0002254_reproductive_system_inflammat3.52953243
3MP0005360_urolithiasis3.31161955
4MP0001835_abnormal_antigen_presentation3.13519492
5MP0002138_abnormal_hepatobiliary_system3.11335474
6MP0000685_abnormal_immune_system3.07597796
7MP0005365_abnormal_bile_salt2.81653126
8MP0008875_abnormal_xenobiotic_pharmacok2.73718472
9MP0003724_increased_susceptibility_to2.57662085
10MP0005085_abnormal_gallbladder_physiolo2.57505684
11MP0002837_dystrophic_cardiac_calcinosis2.21013760
12MP0009785_altered_susceptibility_to2.17777581
13MP0003191_abnormal_cellular_cholesterol2.09353159
14MP0004019_abnormal_vitamin_homeostasis1.97995674
15MP0009643_abnormal_urine_homeostasis1.92903269
16MP0002876_abnormal_thyroid_physiology1.89419169
17MP0003252_abnormal_bile_duct1.87648571
18MP0003300_gastrointestinal_ulcer1.82892257
19MP0002148_abnormal_hypersensitivity_rea1.80952066
20MP0005332_abnormal_amino_acid1.79925186
21MP0010368_abnormal_lymphatic_system1.79356172
22MP0000604_amyloidosis1.74557844
23MP0001873_stomach_inflammation1.73555012
24MP0005025_abnormal_response_to1.66855526
25MP0002877_abnormal_melanocyte_morpholog1.64820592
26MP0005671_abnormal_response_to1.64020802
27MP0005464_abnormal_platelet_physiology1.63282161
28MP0001790_abnormal_immune_system1.61374801
29MP0005387_immune_system_phenotype1.61374801
30MP0005379_endocrine/exocrine_gland_phen1.59488152
31MP0003303_peritoneal_inflammation1.58988871
32MP0010234_abnormal_vibrissa_follicle1.58962017
33MP0009840_abnormal_foam_cell1.58943384
34MP0001853_heart_inflammation1.58709272
35MP0010155_abnormal_intestine_physiology1.54998275
36MP0002166_altered_tumor_susceptibility1.54494341
37MP0010329_abnormal_lipoprotein_level1.52180273
38MP0003195_calcinosis1.51887127
39MP0001666_abnormal_nutrient_absorption1.51405935
40MP0009764_decreased_sensitivity_to1.51281582
41MP0002909_abnormal_adrenal_gland1.50962256
42MP0003436_decreased_susceptibility_to1.49056015
43MP0004782_abnormal_surfactant_physiolog1.43106633
44MP0005083_abnormal_biliary_tract1.41835303
45MP0003186_abnormal_redox_activity1.41190356
46MP0002419_abnormal_innate_immunity1.40658464
47MP0008469_abnormal_protein_level1.40182531
48MP0003879_abnormal_hair_cell1.36774465
49MP0003183_abnormal_peptide_metabolism1.36580444
50MP0005310_abnormal_salivary_gland1.35488786
51MP0006054_spinal_hemorrhage1.31684068
52MP0005058_abnormal_lysosome_morphology1.31203828
53MP0005319_abnormal_enzyme/_coenzyme1.31156866
54MP0001845_abnormal_inflammatory_respons1.29372805
55MP0002396_abnormal_hematopoietic_system1.27667651
56MP0002136_abnormal_kidney_physiology1.25187876
57MP0005000_abnormal_immune_tolerance1.24909740
58MP0005166_decreased_susceptibility_to1.24395933
59MP0005084_abnormal_gallbladder_morpholo1.23973952
60MP0005636_abnormal_mineral_homeostasis1.23826570
61MP0000609_abnormal_liver_physiology1.23731088
62MP0003868_abnormal_feces_composition1.22809371
63MP0001800_abnormal_humoral_immune1.20410485
64MP0001545_abnormal_hematopoietic_system1.18719820
65MP0005397_hematopoietic_system_phenotyp1.18719820
66MP0001879_abnormal_lymphatic_vessel1.18307242
67MP0010386_abnormal_urinary_bladder1.18152173
68MP0002452_abnormal_antigen_presenting1.17451520
69MP0001348_abnormal_lacrimal_gland1.16854646
70MP0003690_abnormal_glial_cell1.16103696
71MP0009780_abnormal_chondrocyte_physiolo1.15729257
72MP0001756_abnormal_urination1.15355747
73MP0001958_emphysema1.14587342
74MP0002723_abnormal_immune_serum1.14571048
75MP0006082_CNS_inflammation1.13982071
76MP0000465_gastrointestinal_hemorrhage1.13499980
77MP0002693_abnormal_pancreas_physiology1.12820536
78MP0002928_abnormal_bile_duct1.11343255
79MP0001764_abnormal_homeostasis1.10592281
80MP0005220_abnormal_exocrine_pancreas1.10472975
81MP0005535_abnormal_body_temperature1.09929637
82MP0000013_abnormal_adipose_tissue1.09736151
83MP0002078_abnormal_glucose_homeostasis1.09487300
84MP0005584_abnormal_enzyme/coenzyme_acti1.09415799
85MP0003638_abnormal_response/metabolism_1.08533668
86MP0003866_abnormal_defecation1.06854505
87MP0003329_amyloid_beta_deposits1.02836233
88MP0002118_abnormal_lipid_homeostasis1.02743997
89MP0001819_abnormal_immune_cell1.01536110
90MP0005448_abnormal_energy_balance1.01432055
91MP0002420_abnormal_adaptive_immunity1.01203278
92MP0002405_respiratory_system_inflammati1.01092415
93MP0001944_abnormal_pancreas_morphology1.00342316
94MP0001765_abnormal_ion_homeostasis1.00272850
95MP0004510_myositis0.98844813
96MP0009278_abnormal_bone_marrow0.97667394
97MP0004264_abnormal_extraembryonic_tissu0.95618165
98MP0001501_abnormal_sleep_pattern0.95530354
99MP0001533_abnormal_skeleton_physiology0.95349633
100MP0003806_abnormal_nucleotide_metabolis0.92239486
101MP0004147_increased_porphyrin_level0.91488376
102MP0002006_tumorigenesis0.91464155
103MP0000598_abnormal_liver_morphology0.90907887
104MP0000343_altered_response_to0.90442184
105MP0009763_increased_sensitivity_to0.89878676
106MP0002971_abnormal_brown_adipose0.86990206
107MP0003763_abnormal_thymus_physiology0.86411404
108MP0001346_abnormal_lacrimal_gland0.85655330
109MP0003943_abnormal_hepatobiliary_system0.85276001
110MP0004808_abnormal_hematopoietic_stem0.84865432
111MP0004947_skin_inflammation0.84569342
112MP0000716_abnormal_immune_system0.84221297
113MP0005167_abnormal_blood-brain_barrier0.84150974
114MP0003075_altered_response_to0.81769398
115MP0000681_abnormal_thyroid_gland0.79006374
116MP0009379_abnormal_foot_pigmentation0.78381624
117MP0002998_abnormal_bone_remodeling0.77470790
118MP0003011_delayed_dark_adaptation0.76828082
119MP0009642_abnormal_blood_homeostasis0.75986305
120MP0005645_abnormal_hypothalamus_physiol0.75237669
121MP0005075_abnormal_melanosome_morpholog0.74967119
122MP0000689_abnormal_spleen_morphology0.74863485
123MP0009765_abnormal_xenobiotic_induced0.74553393
124MP0003172_abnormal_lysosome_physiology0.74437925
125MP0002135_abnormal_kidney_morphology0.73706627
126MP0004043_abnormal_pH_regulation0.69446336
127MP0005451_abnormal_body_composition0.66325636
128MP0005164_abnormal_response_to0.65894727
129MP0003953_abnormal_hormone_level0.65750625
130MP0000538_abnormal_urinary_bladder0.63044293
131MP0004270_analgesia0.62959561
132MP0005376_homeostasis/metabolism_phenot0.62001518
133MP0005408_hypopigmentation0.59711295
134MP0000230_abnormal_systemic_arterial0.58649329
135MP0001664_abnormal_digestion0.58523238
136MP0002163_abnormal_gland_morphology0.58252805
137MP0001663_abnormal_digestive_system0.57836067
138MP0000249_abnormal_blood_vessel0.56704866

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)4.24862853
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.14601202
3Abnormality of liposaccharide metabolism (HP:0010968)4.14186425
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.14186425
5Abnormality of glycolipid metabolism (HP:0010969)4.14186425
6Malnutrition (HP:0004395)3.62897645
7Hyperlipoproteinemia (HP:0010980)3.60629862
8Interstitial pulmonary disease (HP:0006530)3.45616556
9Myositis (HP:0100614)3.35748118
10Gout (HP:0001997)3.34513353
11Generalized aminoaciduria (HP:0002909)3.34024180
12Thrombocytosis (HP:0001894)3.30850713
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28087209
14Increased CSF protein (HP:0002922)3.09016832
15Nephritis (HP:0000123)3.05322843
16Hyperactive renin-angiotensin system (HP:0000841)3.05105508
17Elevated erythrocyte sedimentation rate (HP:0003565)3.05087300
18Systemic lupus erythematosus (HP:0002725)3.02499116
19Vacuolated lymphocytes (HP:0001922)2.92424579
20Conjugated hyperbilirubinemia (HP:0002908)2.88778481
21Abnormality of purine metabolism (HP:0004352)2.88336473
22Abnormality of fatty-acid metabolism (HP:0004359)2.77288836
23Hypokalemic alkalosis (HP:0001949)2.73154378
24Complement deficiency (HP:0004431)2.73066281
25Intrahepatic cholestasis (HP:0001406)2.71549982
26Progressive neurologic deterioration (HP:0002344)2.71241720
27Hypoglycemic coma (HP:0001325)2.71233284
28Abnormality of vitamin metabolism (HP:0100508)2.69596583
29Hypolipoproteinemia (HP:0010981)2.68380494
30Abnormality of proline metabolism (HP:0010907)2.67732162
31Hydroxyprolinuria (HP:0003080)2.67732162
32Abnormality of monocarboxylic acid metabolism (HP:0010996)2.64282557
33Ketoacidosis (HP:0001993)2.62418539
34Abnormality of pyrimidine metabolism (HP:0004353)2.60784740
35Ketosis (HP:0001946)2.58981729
36Loss of speech (HP:0002371)2.57142400
37Deep venous thrombosis (HP:0002625)2.54710195
38Abnormality of the intrinsic pathway (HP:0010989)2.53729003
39Xanthomatosis (HP:0000991)2.50186880
40Impaired platelet aggregation (HP:0003540)2.49506530
41Abnormal platelet function (HP:0011869)2.49506530
42Prolonged partial thromboplastin time (HP:0003645)2.49081116
43Alkalosis (HP:0001948)2.45331339
44Esophageal varix (HP:0002040)2.45052069
45Joint hemorrhage (HP:0005261)2.44212644
46Abnormality of chloride homeostasis (HP:0011422)2.43191361
47Nuclear cataract (HP:0100018)2.41357191
48Orchitis (HP:0100796)2.41276187
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.38641004
50Hyperglycinuria (HP:0003108)2.37878578
51Steatorrhea (HP:0002570)2.37599016
52Eczematoid dermatitis (HP:0000976)2.36984818
53Epistaxis (HP:0000421)2.36863551
54Renal salt wasting (HP:0000127)2.36803721
55Spontaneous hematomas (HP:0007420)2.35981782
56Hyperammonemia (HP:0001987)2.35924352
57Abnormality of vitamin B metabolism (HP:0004340)2.35026896
58Recurrent bacterial skin infections (HP:0005406)2.34491678
59Increased cerebral lipofuscin (HP:0011813)2.33847370
60Cardiovascular calcification (HP:0011915)2.32075689
61Proximal tubulopathy (HP:0000114)2.31071156
62Abnormality of nucleobase metabolism (HP:0010932)2.30816505
63Abnormality of renal excretion (HP:0011036)2.30774411
64Abnormality of the nasal mucosa (HP:0000433)2.30689848
65Abnormality of the common coagulation pathway (HP:0010990)2.30494123
66Hyperuricemia (HP:0002149)2.29879061
67Increased purine levels (HP:0004368)2.29879061
68Gingival bleeding (HP:0000225)2.27965914
69Congenital sensorineural hearing impairment (HP:0008527)2.27899917
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.27252996
71Chronic otitis media (HP:0000389)2.25429616
72Glomerulonephritis (HP:0000099)2.21721631
73Prolonged bleeding time (HP:0003010)2.17630571
74Mucopolysacchariduria (HP:0008155)2.17275764
75Urinary glycosaminoglycan excretion (HP:0003541)2.17275764
76Cardiomegaly (HP:0001640)2.16997587
77Irritability (HP:0000737)2.16821332
78Petechiae (HP:0000967)2.16224643
79Delayed CNS myelination (HP:0002188)2.16080034
80Thrombophlebitis (HP:0004418)2.14476347
81IgM deficiency (HP:0002850)2.14270696
82Reduced antithrombin III activity (HP:0001976)2.13130072
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.13029665
84Abnormal urine output (HP:0012590)2.11469233
85Dysostosis multiplex (HP:0000943)2.08737985
86Arterial thrombosis (HP:0004420)2.08380682
87Polyuria (HP:0000103)2.08285006
88Hyperaldosteronism (HP:0000859)2.08172614
89Renal tubular acidosis (HP:0001947)2.08138671
90Abnormality of complement system (HP:0005339)2.08054063
91Epidermoid cyst (HP:0200040)2.08051564
92Hematochezia (HP:0002573)2.07066018
93Prolonged neonatal jaundice (HP:0006579)2.05953607
94Late onset (HP:0003584)2.05077474
95Amyloidosis (HP:0011034)2.04929519
96Protuberant abdomen (HP:0001538)2.03472234
97Abnormality of urine glucose concentration (HP:0011016)2.02677220
98Glycosuria (HP:0003076)2.02677220
99Metabolic alkalosis (HP:0200114)2.02451009
100Dicarboxylic aciduria (HP:0003215)2.02035410
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02035410
102Abnormal delayed hypersensitivity skin test (HP:0002963)2.01392930
103Abnormality of renin-angiotensin system (HP:0000847)2.00685956
104Hypophosphatemia (HP:0002148)1.99655001
105Beaking of vertebral bodies (HP:0004568)1.98463772
106Pulmonary embolism (HP:0002204)1.98168863
107Recurrent skin infections (HP:0001581)1.97375948
108Recurrent abscess formation (HP:0002722)1.97265398
109Increased circulating renin level (HP:0000848)1.96184249
110Vascular calcification (HP:0004934)1.94296979
111Onycholysis (HP:0001806)1.93655813
112Hypoalphalipoproteinemia (HP:0003233)1.93156256
113Recurrent gram-negative bacterial infections (HP:0005420)1.93062910
114Abnormality of magnesium homeostasis (HP:0004921)1.92004231
115Colitis (HP:0002583)1.91661273
116Abnormality of iron homeostasis (HP:0011031)1.90768736
117Hyperglycemia (HP:0003074)1.89865790
118J-shaped sella turcica (HP:0002680)1.89309623
119Polycythemia (HP:0001901)1.89245616
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89205908
121Abnormality of polysaccharide metabolism (HP:0011012)1.89205908
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89205908
123Menorrhagia (HP:0000132)1.88811050
124Retinal atrophy (HP:0001105)1.88548853
125Skin nodule (HP:0200036)1.88462034
126Abnormality of serine family amino acid metabolism (HP:0010894)1.88273636
127Abnormality of glycine metabolism (HP:0010895)1.88273636
128Vertebral compression fractures (HP:0002953)1.88255246
129Fat malabsorption (HP:0002630)1.88036918
130Abnormality of macrophages (HP:0004311)1.87556439
131Hypomagnesemia (HP:0002917)1.87403710
132Pancreatitis (HP:0001733)1.86943438
133Mitral stenosis (HP:0001718)1.86314608
134Metabolic acidosis (HP:0001942)1.85172713
135Periodontitis (HP:0000704)1.85114842
136Optic neuritis (HP:0100653)1.84140484
137Retrobulbar optic neuritis (HP:0100654)1.84140484
138Purpura (HP:0000979)1.84052303
139Hypoglycemic seizures (HP:0002173)1.82875376
140Rickets (HP:0002748)1.82787644
141Hypothermia (HP:0002045)1.82665106
142Joint swelling (HP:0001386)1.81019596
143Potter facies (HP:0002009)1.80977409
144Facial shape deformation (HP:0011334)1.80977409
145Increased serum ferritin (HP:0003281)1.79430086
146Hemorrhage of the eye (HP:0011885)1.75769809
147Bone cyst (HP:0012062)1.75695103
148Abdominal distention (HP:0003270)1.74709705
149Chronic diarrhea (HP:0002028)1.72872430
150Axonal loss (HP:0003447)1.72629046
151Hyperphosphaturia (HP:0003109)1.71687149
152Abnormality of transition element cation homeostasis (HP:0011030)1.71381460
153Myocardial infarction (HP:0001658)1.71161457
154Hypotension (HP:0002615)1.71142740
155Stroke (HP:0001297)1.70600637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.25999604
2ERN13.20643500
3TIE13.16500849
4TGFBR22.77139208
5BCKDK2.73949052
6KIT2.53512979
7FLT32.52577814
8MAPK152.47452633
9TGFBR12.46561975
10MAP3K142.40723577
11TBK12.28696238
12FGFR42.12608934
13TAOK12.08830558
14TYK21.98806472
15JAK31.97447087
16TEC1.93222918
17EPHA31.92550385
18BTK1.91171107
19IRAK31.83519925
20IRAK41.77088534
21IKBKE1.76786143
22DAPK21.73412828
23EPHB11.65079599
24GRK71.65006251
25TNK21.62971958
26ZAP701.61433930
27TAOK31.56859885
28KDR1.56755246
29IKBKB1.56053160
30NLK1.50714263
31NME21.50681381
32INSRR1.49302092
33MAP2K31.43826375
34CDC42BPA1.43722901
35MAP3K21.41301688
36PIM21.39515583
37MATK1.39290967
38CHUK1.38792674
39SIK11.30653536
40PTK61.30638248
41MAP4K11.29469858
42MYLK1.29207146
43TRPM71.23168968
44LRRK21.19827833
45RIPK41.19608106
46DYRK1B1.18207074
47MAP3K31.13353677
48FRK1.13050178
49MAP2K21.10012773
50MAP3K121.09764010
51PIK3CG1.08061662
52DYRK31.07464392
53CSF1R1.06489166
54PRKG21.02572451
55TRIB31.01819180
56RIPK11.00971563
57EPHA20.99578225
58RPS6KB20.99132962
59BLK0.98379016
60IRAK10.98231675
61PHKG10.97438843
62PHKG20.97438843
63DDR20.96876118
64WNK40.96256911
65PDPK10.95375074
66JAK10.94941435
67MAP3K110.93040704
68NEK90.91817034
69STK160.91275388
70ADRBK20.91200498
71YES10.90384056
72TNIK0.89466666
73PINK10.87058607
74HIPK20.86170939
75FGFR20.86047145
76MUSK0.84706253
77MST40.83968366
78NTRK30.83210665
79ABL20.80411560
80BMPR20.79630053
81SYK0.78283930
82MAP2K60.78121427
83MAPKAPK30.77579528
84PKN20.75138678
85PDK10.75087991
86JAK20.74721567
87BMPR1B0.72955530
88FGFR30.72546495
89CAMK2D0.71562728
90WNK30.71105261
91MST1R0.70527530
92PRKACG0.70195604
93TXK0.69190548
94PAK40.68704229
95EEF2K0.67419457
96OXSR10.66191215
97TESK10.66089445
98PRKCE0.65870583
99MAPKAPK50.64088149
100PRKD20.62359733
101SIK30.61739501
102RPS6KA40.61103459
103CDK80.60331885
104PAK30.59427995
105PASK0.59424869
106TAOK20.58307665
107PRPF4B0.57992993
108CAMKK20.56578537
109LYN0.56291357
110ERBB30.55447021
111PRKAA20.54769135
112FGR0.54132722
113GRK60.53224819
114MAPK110.53162421
115MAP4K20.51751783
116MAPKAPK20.50035951
117PIK3CA0.49474650
118PIM10.49441241
119MAP3K10.49141718
120PTK20.48751018
121LCK0.47303484
122MAP3K40.47070418
123IRAK20.45135608
124MAP3K130.43964509
125ITK0.43330328
126PRKCA0.42547180
127FES0.42446331
128ILK0.42131875
129PRKCZ0.42023700
130PRKCD0.41728187
131IGF1R0.41577121
132LMTK20.41421860
133SCYL20.40909876
134PRKG10.40160131
135CSK0.39110656
136MAPK40.38955153
137MAP3K70.38024140
138GRK10.37981396
139GSK3A0.37554749
140FER0.37334421
141HCK0.35743528
142STK240.35038278

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90132547
2Pentose and glucuronate interconversions_Homo sapiens_hsa000402.82899186
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.58104502
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.47585090
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21965258
6Fatty acid degradation_Homo sapiens_hsa000712.21473043
7Caffeine metabolism_Homo sapiens_hsa002322.16404390
8Tryptophan metabolism_Homo sapiens_hsa003802.15430100
9Complement and coagulation cascades_Homo sapiens_hsa046101.99248907
10Peroxisome_Homo sapiens_hsa041461.95016137
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94410254
12Histidine metabolism_Homo sapiens_hsa003401.92578027
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92260130
14Sulfur metabolism_Homo sapiens_hsa009201.81690809
15Folate biosynthesis_Homo sapiens_hsa007901.78898660
16Staphylococcus aureus infection_Homo sapiens_hsa051501.77070368
17Chemical carcinogenesis_Homo sapiens_hsa052041.74819392
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69741139
19Protein export_Homo sapiens_hsa030601.64437132
20Linoleic acid metabolism_Homo sapiens_hsa005911.63098497
21Other glycan degradation_Homo sapiens_hsa005111.61035041
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58719332
23Sulfur relay system_Homo sapiens_hsa041221.52681809
24Selenocompound metabolism_Homo sapiens_hsa004501.44258547
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.40156869
26Propanoate metabolism_Homo sapiens_hsa006401.39504686
27Type I diabetes mellitus_Homo sapiens_hsa049401.36943781
28beta-Alanine metabolism_Homo sapiens_hsa004101.34352903
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.32033833
30Vitamin digestion and absorption_Homo sapiens_hsa049771.31508589
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.30577694
32Antigen processing and presentation_Homo sapiens_hsa046121.28396534
33Mineral absorption_Homo sapiens_hsa049781.28250807
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.27536835
35PPAR signaling pathway_Homo sapiens_hsa033201.25394737
36Nitrogen metabolism_Homo sapiens_hsa009101.24854901
37Leishmaniasis_Homo sapiens_hsa051401.24699645
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24695194
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.24649954
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.24446998
41Starch and sucrose metabolism_Homo sapiens_hsa005001.22981002
42ABC transporters_Homo sapiens_hsa020101.22757191
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20250552
44Retinol metabolism_Homo sapiens_hsa008301.19637482
45Arginine biosynthesis_Homo sapiens_hsa002201.18185412
46Renin-angiotensin system_Homo sapiens_hsa046141.15885512
47Fatty acid metabolism_Homo sapiens_hsa012121.15192150
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13467508
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12823203
50Phenylalanine metabolism_Homo sapiens_hsa003601.12211121
51Glutathione metabolism_Homo sapiens_hsa004801.08554574
52Asthma_Homo sapiens_hsa053101.07142563
53Butanoate metabolism_Homo sapiens_hsa006501.06896586
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03764657
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00023175
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97325226
57Vitamin B6 metabolism_Homo sapiens_hsa007500.96616804
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95692615
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95312674
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93416642
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92912331
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91644554
63Prion diseases_Homo sapiens_hsa050200.91194412
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89697569
65Pertussis_Homo sapiens_hsa051330.88534132
66Tyrosine metabolism_Homo sapiens_hsa003500.87406374
67Lysosome_Homo sapiens_hsa041420.86198963
68Arachidonic acid metabolism_Homo sapiens_hsa005900.85998244
69Rheumatoid arthritis_Homo sapiens_hsa053230.85625981
70Galactose metabolism_Homo sapiens_hsa000520.83426978
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82993793
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.82210272
73N-Glycan biosynthesis_Homo sapiens_hsa005100.81648901
74Autoimmune thyroid disease_Homo sapiens_hsa053200.80894272
75Ribosome_Homo sapiens_hsa030100.80307267
76Fructose and mannose metabolism_Homo sapiens_hsa000510.80199742
77Primary immunodeficiency_Homo sapiens_hsa053400.80047969
78Collecting duct acid secretion_Homo sapiens_hsa049660.80000121
79Graft-versus-host disease_Homo sapiens_hsa053320.78625329
80Sphingolipid metabolism_Homo sapiens_hsa006000.78487532
81Bile secretion_Homo sapiens_hsa049760.76808346
82Legionellosis_Homo sapiens_hsa051340.76594601
83Measles_Homo sapiens_hsa051620.74801133
84Malaria_Homo sapiens_hsa051440.73830606
85Pyruvate metabolism_Homo sapiens_hsa006200.73757814
86Toxoplasmosis_Homo sapiens_hsa051450.73482314
87Osteoclast differentiation_Homo sapiens_hsa043800.71376486
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71095675
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69734631
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69408469
91TNF signaling pathway_Homo sapiens_hsa046680.67899294
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66746336
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65795229
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62054960
95Ether lipid metabolism_Homo sapiens_hsa005650.61806792
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61294535
97Arginine and proline metabolism_Homo sapiens_hsa003300.57175970
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.55348469
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54864786
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54825211
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54810680
102Influenza A_Homo sapiens_hsa051640.54466071
103Pentose phosphate pathway_Homo sapiens_hsa000300.53845841
104Phagosome_Homo sapiens_hsa041450.53324806
105Fatty acid elongation_Homo sapiens_hsa000620.52287870
106Fat digestion and absorption_Homo sapiens_hsa049750.52201262
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50476606
108Hepatitis C_Homo sapiens_hsa051600.49076037
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48984858
110B cell receptor signaling pathway_Homo sapiens_hsa046620.48036956
111Tuberculosis_Homo sapiens_hsa051520.47905882
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47869422
113Allograft rejection_Homo sapiens_hsa053300.46231995
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45445401
115Hematopoietic cell lineage_Homo sapiens_hsa046400.44313391
116Insulin secretion_Homo sapiens_hsa049110.41500717
117Glycerolipid metabolism_Homo sapiens_hsa005610.40552840
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40462491
119Herpes simplex infection_Homo sapiens_hsa051680.40412531
120Apoptosis_Homo sapiens_hsa042100.39992576
121Insulin resistance_Homo sapiens_hsa049310.39733001
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.39689773
123Acute myeloid leukemia_Homo sapiens_hsa052210.39612667
124African trypanosomiasis_Homo sapiens_hsa051430.38418886
125Protein digestion and absorption_Homo sapiens_hsa049740.38020104
126Prolactin signaling pathway_Homo sapiens_hsa049170.37936793
127Vibrio cholerae infection_Homo sapiens_hsa051100.37807207
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.37342969
129Metabolic pathways_Homo sapiens_hsa011000.34048266
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.24748122
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24150225
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23813011
133Glucagon signaling pathway_Homo sapiens_hsa049220.23730691
134Carbon metabolism_Homo sapiens_hsa012000.22602660
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21242250
136Renin secretion_Homo sapiens_hsa049240.21014074

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »