TMEM178A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.14924962
2synaptic vesicle docking involved in exocytosis (GO:0016081)6.90241882
3glutamate secretion (GO:0014047)6.37841338
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.16914953
5synaptic vesicle exocytosis (GO:0016079)5.84183807
6regulation of synaptic vesicle exocytosis (GO:2000300)5.66136085
7cellular potassium ion homeostasis (GO:0030007)5.47914220
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.47302364
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.36787486
10vocalization behavior (GO:0071625)5.19407424
11neurotransmitter secretion (GO:0007269)5.10936742
12regulation of synaptic vesicle transport (GO:1902803)5.00203475
13sodium ion export (GO:0071436)4.99102844
14neuronal action potential propagation (GO:0019227)4.87362828
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.85637813
16neuronal ion channel clustering (GO:0045161)4.84868158
17postsynaptic membrane organization (GO:0001941)4.73111013
18cerebellar granule cell differentiation (GO:0021707)4.66835898
19locomotory exploration behavior (GO:0035641)4.65262217
20positive regulation of synapse maturation (GO:0090129)4.57130680
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.55146044
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.49106800
23neurotransmitter-gated ion channel clustering (GO:0072578)4.44931213
24gamma-aminobutyric acid transport (GO:0015812)4.39704318
25axon ensheathment in central nervous system (GO:0032291)4.37427468
26central nervous system myelination (GO:0022010)4.37427468
27regulation of neuronal synaptic plasticity (GO:0048168)4.35648698
28neuron cell-cell adhesion (GO:0007158)4.34374540
29protein localization to synapse (GO:0035418)4.32086759
30dendritic spine morphogenesis (GO:0060997)4.21313487
31auditory behavior (GO:0031223)4.16530307
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.15186567
33regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.15051074
34presynaptic membrane organization (GO:0097090)4.14850733
35neurotransmitter transport (GO:0006836)4.14640295
36synaptic transmission, glutamatergic (GO:0035249)4.06920405
37exploration behavior (GO:0035640)3.99498885
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97896616
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.91901250
40presynaptic membrane assembly (GO:0097105)3.91095682
41L-amino acid import (GO:0043092)3.89922077
42regulation of synapse structural plasticity (GO:0051823)3.84733621
43cerebellar Purkinje cell differentiation (GO:0021702)3.83673048
44regulation of neurotransmitter levels (GO:0001505)3.81427542
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80796758
46regulation of glutamate receptor signaling pathway (GO:1900449)3.79726866
47potassium ion homeostasis (GO:0055075)3.79127591
48regulation of synapse maturation (GO:0090128)3.77312490
49glutamate receptor signaling pathway (GO:0007215)3.76474421
50transmission of nerve impulse (GO:0019226)3.74030175
51layer formation in cerebral cortex (GO:0021819)3.71953648
52neuron-neuron synaptic transmission (GO:0007270)3.71026803
53synaptic vesicle endocytosis (GO:0048488)3.70345315
54cellular sodium ion homeostasis (GO:0006883)3.61560240
55positive regulation of membrane potential (GO:0045838)3.61485613
56potassium ion import (GO:0010107)3.59421179
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.58575080
58positive regulation of dendritic spine development (GO:0060999)3.57219218
59regulation of neurotransmitter secretion (GO:0046928)3.57195600
60amino acid import (GO:0043090)3.56384732
61cell communication by electrical coupling (GO:0010644)3.51263339
62regulation of voltage-gated calcium channel activity (GO:1901385)3.50855338
63axonal fasciculation (GO:0007413)3.45107600
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.42910676
65neurotransmitter uptake (GO:0001504)3.42752409
66cell migration in hindbrain (GO:0021535)3.39628484
67response to auditory stimulus (GO:0010996)3.38086317
68mechanosensory behavior (GO:0007638)3.37653487
69gamma-aminobutyric acid signaling pathway (GO:0007214)3.37106144
70regulation of postsynaptic membrane potential (GO:0060078)3.35775534
71regulation of dendritic spine morphogenesis (GO:0061001)3.35376683
72neuromuscular process controlling balance (GO:0050885)3.33782942
73neuron recognition (GO:0008038)3.29562150
74regulation of neurotransmitter transport (GO:0051588)3.26985845
75membrane depolarization during action potential (GO:0086010)3.26245329
76cell differentiation in hindbrain (GO:0021533)3.24632190
77regulation of synaptic plasticity (GO:0048167)3.21983684
78long-term memory (GO:0007616)3.20787318
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20467969
80establishment of mitochondrion localization (GO:0051654)3.16046889
81regulation of vesicle fusion (GO:0031338)3.14200114
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13207277
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11063666
84acidic amino acid transport (GO:0015800)3.07809936
85membrane depolarization (GO:0051899)3.07479898
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.06412449
87proline transport (GO:0015824)3.05754958
88neuromuscular synaptic transmission (GO:0007274)3.04507083
89dendritic spine organization (GO:0097061)3.02929425
90regulation of dendritic spine development (GO:0060998)3.02690987
91pyrimidine nucleobase catabolic process (GO:0006208)3.01569200
92synaptic vesicle transport (GO:0048489)2.97541059
93establishment of synaptic vesicle localization (GO:0097480)2.97541059
94adult walking behavior (GO:0007628)2.97419734
95neuromuscular process controlling posture (GO:0050884)2.95239137
96synaptic transmission (GO:0007268)2.94707741
97positive regulation of neurotransmitter transport (GO:0051590)2.93772534
98positive regulation of neurotransmitter secretion (GO:0001956)2.92885247
99negative regulation of dendrite morphogenesis (GO:0050774)2.92883527
100C4-dicarboxylate transport (GO:0015740)2.90681982

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58997592
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.10209709
3REST_21632747_ChIP-Seq_MESCs_Mouse3.08507393
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04022290
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98463038
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96216911
7GBX2_23144817_ChIP-Seq_PC3_Human2.80528332
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.78423881
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.70018800
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65086645
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65086645
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64038581
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52808014
14DROSHA_22980978_ChIP-Seq_HELA_Human2.52515865
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.49664839
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.46434556
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.43865386
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43073660
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.41857580
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38159483
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37071805
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36572826
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34817350
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.31750610
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08912314
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04115654
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.88811450
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83211636
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74107580
30RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.67662677
31RNF2_27304074_Chip-Seq_NSC_Mouse1.63931157
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.57225689
33RING1B_27294783_Chip-Seq_ESCs_Mouse1.56611406
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.48943466
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48796027
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46785553
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46702827
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46585491
39AR_21572438_ChIP-Seq_LNCaP_Human1.44451219
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38870550
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37792358
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37159840
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36955809
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36768795
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30146799
46SMAD4_21799915_ChIP-Seq_A2780_Human1.26918859
47TAF15_26573619_Chip-Seq_HEK293_Human1.25767203
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.24394501
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23994607
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.23985348
51OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21906694
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19756873
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19621421
54WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18194642
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17626104
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17626104
57AR_19668381_ChIP-Seq_PC3_Human1.16607452
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15966293
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15249262
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.14323900
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.13904011
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08546274
63KDM2B_26808549_Chip-Seq_K562_Human1.08494270
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.07380463
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06302224
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06195132
67P300_19829295_ChIP-Seq_ESCs_Human1.05639029
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05063524
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04722452
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03917718
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03465030
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03341906
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02688667
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02397620
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02273197
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01144603
77CTCF_27219007_Chip-Seq_Bcells_Human0.97523450
78P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95072798
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94753950
80IGF1R_20145208_ChIP-Seq_DFB_Human0.91758321
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91217904
82TP53_20018659_ChIP-ChIP_R1E_Mouse0.90991420
83SMAD3_21741376_ChIP-Seq_ESCs_Human0.90904110
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90624372
85TCF4_23295773_ChIP-Seq_U87_Human0.90410391
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90298332
87STAT3_23295773_ChIP-Seq_U87_Human0.89744831
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89105488
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88948795
90SOX9_26525672_Chip-Seq_HEART_Mouse0.88555316
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87030375
92TET1_21490601_ChIP-Seq_MESCs_Mouse0.86840451
93AR_25329375_ChIP-Seq_VCAP_Human0.86659803
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86448896
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85676897
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83877519
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83415564
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83121357
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.82909721
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80590039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.53382742
2MP0003880_abnormal_central_pattern5.17955333
3MP0004270_analgesia3.91343912
4MP0005423_abnormal_somatic_nervous3.86901864
5MP0003635_abnormal_synaptic_transmissio3.58313118
6MP0002064_seizures3.22237153
7MP0009745_abnormal_behavioral_response2.99312868
8MP0002063_abnormal_learning/memory/cond2.95175254
9MP0009046_muscle_twitch2.86785334
10MP0001486_abnormal_startle_reflex2.82890978
11MP0002272_abnormal_nervous_system2.82021719
12MP0002734_abnormal_mechanical_nocicepti2.63980565
13MP0001968_abnormal_touch/_nociception2.58207976
14MP0002572_abnormal_emotion/affect_behav2.48616204
15MP0004885_abnormal_endolymph2.19927611
16MP0000778_abnormal_nervous_system2.19052904
17MP0008569_lethality_at_weaning2.18689001
18MP0001501_abnormal_sleep_pattern1.98678417
19MP0002735_abnormal_chemical_nociception1.97769015
20MP0002736_abnormal_nociception_after1.96320403
21MP0003122_maternal_imprinting1.96124741
22MP0003787_abnormal_imprinting1.85431303
23MP0003329_amyloid_beta_deposits1.83267517
24MP0001970_abnormal_pain_threshold1.82048736
25MP0003879_abnormal_hair_cell1.76691662
26MP0006276_abnormal_autonomic_nervous1.75646855
27MP0002557_abnormal_social/conspecific_i1.74411845
28MP0002067_abnormal_sensory_capabilities1.72780286
29MP0002733_abnormal_thermal_nociception1.71356074
30MP0003878_abnormal_ear_physiology1.67032384
31MP0005377_hearing/vestibular/ear_phenot1.67032384
32MP0001984_abnormal_olfaction1.66490171
33MP0001529_abnormal_vocalization1.63757669
34MP0001440_abnormal_grooming_behavior1.63040469
35MP0004811_abnormal_neuron_physiology1.62207643
36MP0002184_abnormal_innervation1.61498900
37MP0004742_abnormal_vestibular_system1.60153587
38MP0001502_abnormal_circadian_rhythm1.54459027
39MP0000955_abnormal_spinal_cord1.53013714
40MP0002882_abnormal_neuron_morphology1.50218548
41MP0005386_behavior/neurological_phenoty1.44635153
42MP0004924_abnormal_behavior1.44635153
43MP0002066_abnormal_motor_capabilities/c1.42283608
44MP0000566_synostosis1.38982659
45MP0003633_abnormal_nervous_system1.37259472
46MP0002102_abnormal_ear_morphology1.30722272
47MP0001177_atelectasis1.29907189
48MP0003690_abnormal_glial_cell1.25183427
49MP0005646_abnormal_pituitary_gland1.24139650
50MP0002822_catalepsy1.21842850
51MP0003123_paternal_imprinting1.20102221
52MP0002152_abnormal_brain_morphology1.20051925
53MP0000920_abnormal_myelination1.19921010
54MP0003631_nervous_system_phenotype1.19742446
55MP0001963_abnormal_hearing_physiology1.16093988
56MP0006292_abnormal_olfactory_placode1.11180859
57MP0001485_abnormal_pinna_reflex1.10831774
58MP0005551_abnormal_eye_electrophysiolog1.10376649
59MP0002653_abnormal_ependyma_morphology1.07400703
60MP0001905_abnormal_dopamine_level1.06250444
61MP0002638_abnormal_pupillary_reflex1.06058997
62MP0001188_hyperpigmentation1.05728739
63MP0004142_abnormal_muscle_tone1.02270975
64MP0005499_abnormal_olfactory_system1.00561532
65MP0005394_taste/olfaction_phenotype1.00561532
66MP0009780_abnormal_chondrocyte_physiolo0.98725428
67MP0003121_genomic_imprinting0.97255750
68MP0003632_abnormal_nervous_system0.96453432
69MP0003634_abnormal_glial_cell0.95157296
70MP0001346_abnormal_lacrimal_gland0.94227507
71MP0002752_abnormal_somatic_nervous0.93391650
72MP0002229_neurodegeneration0.92266022
73MP0000569_abnormal_digit_pigmentation0.91163631
74MP0002909_abnormal_adrenal_gland0.90503270
75MP0000026_abnormal_inner_ear0.90448626
76MP0003938_abnormal_ear_development0.89237037
77MP0000579_abnormal_nail_morphology0.87029180
78MP0005248_abnormal_Harderian_gland0.81206833
79MP0003861_abnormal_nervous_system0.80105523
80MP0005645_abnormal_hypothalamus_physiol0.77721759
81MP0001299_abnormal_eye_distance/0.77037581
82MP0002069_abnormal_eating/drinking_beha0.75340115
83MP0008877_abnormal_DNA_methylation0.74920437
84MP0004145_abnormal_muscle_electrophysio0.72950515
85MP0000631_abnormal_neuroendocrine_gland0.72630177
86MP0004147_increased_porphyrin_level0.72489001
87MP0005167_abnormal_blood-brain_barrier0.72354641
88MP0008872_abnormal_physiological_respon0.72241738
89MP0003137_abnormal_impulse_conducting0.69906930
90MP0006072_abnormal_retinal_apoptosis0.66827846
91MP0001986_abnormal_taste_sensitivity0.65438631
92MP0004858_abnormal_nervous_system0.65301201
93MP0005623_abnormal_meninges_morphology0.65071131
94MP0000604_amyloidosis0.64908865
95MP0004133_heterotaxia0.62953984
96MP0005253_abnormal_eye_physiology0.59317641
97MP0010769_abnormal_survival0.58502646
98MP0003283_abnormal_digestive_organ0.57631922
99MP0003119_abnormal_digestive_system0.57324109
100MP0010770_preweaning_lethality0.57032740

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.29896435
2Myokymia (HP:0002411)7.29879532
3Focal seizures (HP:0007359)5.80295263
4Febrile seizures (HP:0002373)5.23840896
5Atonic seizures (HP:0010819)5.04771144
6Epileptic encephalopathy (HP:0200134)4.77244166
7Action tremor (HP:0002345)4.52186608
8Supranuclear gaze palsy (HP:0000605)3.97758952
9Diplopia (HP:0000651)3.91308241
10Abnormality of binocular vision (HP:0011514)3.91308241
11Generalized tonic-clonic seizures (HP:0002069)3.89238967
12Abnormal eating behavior (HP:0100738)3.72294066
13Limb dystonia (HP:0002451)3.70687788
14Progressive cerebellar ataxia (HP:0002073)3.51847673
15Dialeptic seizures (HP:0011146)3.47052006
16Spastic gait (HP:0002064)3.46700420
17Absence seizures (HP:0002121)3.46587730
18Ankle clonus (HP:0011448)3.45765646
19Cerebral hypomyelination (HP:0006808)3.35412272
20Postural instability (HP:0002172)3.31611172
21Neurofibrillary tangles (HP:0002185)3.27819621
22Visual hallucinations (HP:0002367)3.09920391
23Status epilepticus (HP:0002133)3.03010378
24Annular pancreas (HP:0001734)3.02788797
25Aplasia involving bones of the upper limbs (HP:0009823)2.95523682
26Aplasia of the phalanges of the hand (HP:0009802)2.95523682
27Aplasia involving bones of the extremities (HP:0009825)2.95523682
28Abnormality of the corticospinal tract (HP:0002492)2.94796115
29Polyphagia (HP:0002591)2.88386442
30Hemiparesis (HP:0001269)2.87312036
31Abnormality of the lower motor neuron (HP:0002366)2.84365481
32Torticollis (HP:0000473)2.79977581
33Urinary bladder sphincter dysfunction (HP:0002839)2.76349128
34Impaired vibration sensation in the lower limbs (HP:0002166)2.76176772
35Dysmetria (HP:0001310)2.75932804
36Sleep apnea (HP:0010535)2.75173695
37Hemiplegia (HP:0002301)2.70703521
38Urinary urgency (HP:0000012)2.62953278
39Epileptiform EEG discharges (HP:0011182)2.59214707
40Mutism (HP:0002300)2.58745034
41Akinesia (HP:0002304)2.58587933
42Intention tremor (HP:0002080)2.55202726
43Truncal ataxia (HP:0002078)2.49502038
44Tetraplegia (HP:0002445)2.44527496
45Amblyopia (HP:0000646)2.44401600
46Papilledema (HP:0001085)2.41974645
47Gait imbalance (HP:0002141)2.39999010
48Abnormality of the labia minora (HP:0012880)2.37217959
49Focal dystonia (HP:0004373)2.35805266
50Poor eye contact (HP:0000817)2.35157588
51Cerebral inclusion bodies (HP:0100314)2.34115077
52EEG with generalized epileptiform discharges (HP:0011198)2.33236989
53Anxiety (HP:0000739)2.28042077
54Depression (HP:0000716)2.27584033
55Morphological abnormality of the pyramidal tract (HP:0002062)2.27043559
56Obstructive sleep apnea (HP:0002870)2.26594450
57Dysdiadochokinesis (HP:0002075)2.26209243
58CNS hypomyelination (HP:0003429)2.25602537
59Alacrima (HP:0000522)2.25502528
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.25060051
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.25060051
62Bradykinesia (HP:0002067)2.24760898
63Delusions (HP:0000746)2.24752000
64Lower limb muscle weakness (HP:0007340)2.24222061
65Peripheral hypomyelination (HP:0007182)2.23487872
66Hypsarrhythmia (HP:0002521)2.22707962
67Megalencephaly (HP:0001355)2.22596082
68Broad-based gait (HP:0002136)2.16183717
69Drooling (HP:0002307)2.14929181
70Impaired social interactions (HP:0000735)2.12820359
71Abnormal social behavior (HP:0012433)2.12820359
72Specific learning disability (HP:0001328)2.10313608
73Craniofacial dystonia (HP:0012179)2.06197517
74Impaired smooth pursuit (HP:0007772)2.02087077
75Partial duplication of thumb phalanx (HP:0009944)2.01370312
76Amyotrophic lateral sclerosis (HP:0007354)2.00949788
77Scanning speech (HP:0002168)2.00598087
78Clonus (HP:0002169)1.95500503
79Spastic tetraparesis (HP:0001285)1.95498333
80Excessive salivation (HP:0003781)1.93643884
81Gaze-evoked nystagmus (HP:0000640)1.91841860
82Neuronal loss in central nervous system (HP:0002529)1.90135324
83Failure to thrive in infancy (HP:0001531)1.89426434
84Incomplete penetrance (HP:0003829)1.89296168
85Turricephaly (HP:0000262)1.87086654
86Partial duplication of the phalanx of hand (HP:0009999)1.86851535
87Choreoathetosis (HP:0001266)1.86567569
88Poor suck (HP:0002033)1.81880534
89Decreased lacrimation (HP:0000633)1.80006700
90Rapidly progressive (HP:0003678)1.79354131
91Abnormality of ocular smooth pursuit (HP:0000617)1.78371011
92Increased circulating renin level (HP:0000848)1.78088798
93Apathy (HP:0000741)1.77547782
94Lower limb asymmetry (HP:0100559)1.75938511
95Stereotypic behavior (HP:0000733)1.74653870
96Dyskinesia (HP:0100660)1.74314091
97Mixed hearing impairment (HP:0000410)1.74210587
98Congenital primary aphakia (HP:0007707)1.73756055
99Spastic tetraplegia (HP:0002510)1.73562716
100Impaired vibratory sensation (HP:0002495)1.72388729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.72168768
2MARK14.43564132
3NTRK33.66116010
4PAK63.28330453
5DAPK23.27759007
6NTRK23.12560375
7CASK2.81812048
8UHMK12.73089764
9MAP3K92.48200931
10MINK12.36859760
11PRKD32.33945098
12CAMKK12.23865539
13MAPK132.08076644
14NTRK12.01243751
15PINK11.87803335
16RIPK11.77407535
17CDK191.73451348
18PLK21.72009463
19CAMKK21.55878694
20GRK51.55250407
21CDK51.49179570
22PRKCG1.48788888
23CAMK2B1.46958973
24CAMK11.46795745
25MAP3K41.45094589
26SGK4941.43741552
27SGK2231.43741552
28ARAF1.38970304
29SIK21.34734638
30FGFR21.33990702
31TYRO31.29367465
32DYRK1A1.28709117
33PHKG21.27831812
34PHKG11.27831812
35LATS21.19050123
36TNIK1.17789407
37CDK151.12769949
38PAK31.12042657
39CDK181.11422185
40PKN11.07241480
41PRKCH1.04914789
42CDK11A1.04233921
43SGK21.04204476
44STK111.04081599
45KSR21.03804237
46DAPK11.01218983
47CDK141.00981842
48CAMK2A1.00602194
49DYRK20.88024291
50OXSR10.82431977
51MAP2K70.79722213
52CAMK2G0.79000584
53MARK20.77720183
54SGK30.75520699
55STK380.75262305
56CSNK1G20.73133610
57KSR10.72373825
58SGK10.70981389
59CAMK40.70585034
60MAP2K40.69346399
61PNCK0.65540216
62ROCK20.63778637
63NEK60.62641327
64ALK0.62130590
65PRKCZ0.61930562
66BRSK10.61916558
67MAPK100.57700098
68BCR0.55978006
69CAMK2D0.55907330
70RPS6KA30.54312987
71WNK10.53713805
72LMTK20.52175917
73WNK30.50523594
74ERBB20.48365888
75MAPKAPK50.45037630
76MAPK120.43685096
77MAPK150.43656650
78BRAF0.42780969
79PRKCE0.40693435
80DAPK30.39561592
81PRKACA0.38810681
82RAF10.36341602
83CSNK1G30.35351227
84LIMK10.35028399
85FYN0.34052290
86PRKG10.33669151
87DYRK1B0.33647897
88PRKCA0.33170526
89ROCK10.33050751
90CSNK1E0.31956245
91CSNK1A1L0.31656335
92CSNK1D0.30559489
93PDK10.30509407
94MOS0.30005304
95MAPK80.29317619
96MAP3K130.28621940
97CSNK1G10.26796212
98RET0.26548763
99DMPK0.26178374
100CSNK1A10.25963421

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.57052287
2Synaptic vesicle cycle_Homo sapiens_hsa047213.79100842
3GABAergic synapse_Homo sapiens_hsa047272.90744573
4Glutamatergic synapse_Homo sapiens_hsa047242.77852988
5Circadian entrainment_Homo sapiens_hsa047132.72775855
6Amphetamine addiction_Homo sapiens_hsa050312.67002673
7Morphine addiction_Homo sapiens_hsa050322.64798866
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64330725
9Long-term potentiation_Homo sapiens_hsa047202.57482007
10Insulin secretion_Homo sapiens_hsa049112.40977633
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.35371468
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10503825
13Dopaminergic synapse_Homo sapiens_hsa047282.09687338
14Cocaine addiction_Homo sapiens_hsa050302.08036301
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.90387855
16Gastric acid secretion_Homo sapiens_hsa049711.87077169
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79142163
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71313078
19Cholinergic synapse_Homo sapiens_hsa047251.71153107
20Salivary secretion_Homo sapiens_hsa049701.68630146
21Taste transduction_Homo sapiens_hsa047421.64300589
22Oxytocin signaling pathway_Homo sapiens_hsa049211.50688463
23cAMP signaling pathway_Homo sapiens_hsa040241.44053040
24Calcium signaling pathway_Homo sapiens_hsa040201.38510953
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37986849
26Renin secretion_Homo sapiens_hsa049241.36274076
27Long-term depression_Homo sapiens_hsa047301.35044143
28Cardiac muscle contraction_Homo sapiens_hsa042601.30935056
29Serotonergic synapse_Homo sapiens_hsa047261.29172427
30Olfactory transduction_Homo sapiens_hsa047401.22447244
31Vitamin B6 metabolism_Homo sapiens_hsa007501.20390379
32Axon guidance_Homo sapiens_hsa043601.20065472
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17156315
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.16882022
35Gap junction_Homo sapiens_hsa045401.13978894
36Collecting duct acid secretion_Homo sapiens_hsa049661.11022209
37Phototransduction_Homo sapiens_hsa047441.10839457
38Melanogenesis_Homo sapiens_hsa049161.07532786
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04598766
40Estrogen signaling pathway_Homo sapiens_hsa049151.03481411
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03060026
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00829301
43GnRH signaling pathway_Homo sapiens_hsa049120.98585389
44Bile secretion_Homo sapiens_hsa049760.98379622
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94971743
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91139909
47Oocyte meiosis_Homo sapiens_hsa041140.90491911
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88300332
49Thyroid hormone synthesis_Homo sapiens_hsa049180.84924878
50Pancreatic secretion_Homo sapiens_hsa049720.84684382
51Circadian rhythm_Homo sapiens_hsa047100.81221076
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.72878274
53Glioma_Homo sapiens_hsa052140.71816775
54Nitrogen metabolism_Homo sapiens_hsa009100.70795412
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68399682
56Rap1 signaling pathway_Homo sapiens_hsa040150.68029593
57Vibrio cholerae infection_Homo sapiens_hsa051100.67933217
58Arginine and proline metabolism_Homo sapiens_hsa003300.65848027
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.64903233
60Alzheimers disease_Homo sapiens_hsa050100.64030333
61Histidine metabolism_Homo sapiens_hsa003400.62182557
62Ras signaling pathway_Homo sapiens_hsa040140.60609957
63Type II diabetes mellitus_Homo sapiens_hsa049300.60475408
64ErbB signaling pathway_Homo sapiens_hsa040120.59205838
65Wnt signaling pathway_Homo sapiens_hsa043100.58820218
66MAPK signaling pathway_Homo sapiens_hsa040100.56506675
67Glucagon signaling pathway_Homo sapiens_hsa049220.55515465
68beta-Alanine metabolism_Homo sapiens_hsa004100.55381729
69Inositol phosphate metabolism_Homo sapiens_hsa005620.53914244
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53217071
71Dilated cardiomyopathy_Homo sapiens_hsa054140.52373697
72Dorso-ventral axis formation_Homo sapiens_hsa043200.51192268
73Hippo signaling pathway_Homo sapiens_hsa043900.49774658
74Prion diseases_Homo sapiens_hsa050200.48443035
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47899005
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47255759
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47157366
78Alcoholism_Homo sapiens_hsa050340.45869811
79Tight junction_Homo sapiens_hsa045300.43164662
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42391187
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41797834
82Hedgehog signaling pathway_Homo sapiens_hsa043400.40758142
83Oxidative phosphorylation_Homo sapiens_hsa001900.40669943
84Butanoate metabolism_Homo sapiens_hsa006500.40507707
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.40266496
86Choline metabolism in cancer_Homo sapiens_hsa052310.39939550
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38450606
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37486067
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36143262
90Parkinsons disease_Homo sapiens_hsa050120.32905352
91Protein digestion and absorption_Homo sapiens_hsa049740.30899572
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29229851
93Regulation of autophagy_Homo sapiens_hsa041400.28961033
94Ovarian steroidogenesis_Homo sapiens_hsa049130.28246632
95Endocytosis_Homo sapiens_hsa041440.28047625
96VEGF signaling pathway_Homo sapiens_hsa043700.27799865
97Arginine biosynthesis_Homo sapiens_hsa002200.27723283
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26990559
99Mineral absorption_Homo sapiens_hsa049780.25811688
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25658250

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