

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 7.14924962 |
| 2 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 6.90241882 |
| 3 | glutamate secretion (GO:0014047) | 6.37841338 |
| 4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.16914953 |
| 5 | synaptic vesicle exocytosis (GO:0016079) | 5.84183807 |
| 6 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.66136085 |
| 7 | cellular potassium ion homeostasis (GO:0030007) | 5.47914220 |
| 8 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 5.47302364 |
| 9 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.36787486 |
| 10 | vocalization behavior (GO:0071625) | 5.19407424 |
| 11 | neurotransmitter secretion (GO:0007269) | 5.10936742 |
| 12 | regulation of synaptic vesicle transport (GO:1902803) | 5.00203475 |
| 13 | sodium ion export (GO:0071436) | 4.99102844 |
| 14 | neuronal action potential propagation (GO:0019227) | 4.87362828 |
| 15 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.85637813 |
| 16 | neuronal ion channel clustering (GO:0045161) | 4.84868158 |
| 17 | postsynaptic membrane organization (GO:0001941) | 4.73111013 |
| 18 | cerebellar granule cell differentiation (GO:0021707) | 4.66835898 |
| 19 | locomotory exploration behavior (GO:0035641) | 4.65262217 |
| 20 | positive regulation of synapse maturation (GO:0090129) | 4.57130680 |
| 21 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.55146044 |
| 22 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.49106800 |
| 23 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.44931213 |
| 24 | gamma-aminobutyric acid transport (GO:0015812) | 4.39704318 |
| 25 | axon ensheathment in central nervous system (GO:0032291) | 4.37427468 |
| 26 | central nervous system myelination (GO:0022010) | 4.37427468 |
| 27 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.35648698 |
| 28 | neuron cell-cell adhesion (GO:0007158) | 4.34374540 |
| 29 | protein localization to synapse (GO:0035418) | 4.32086759 |
| 30 | dendritic spine morphogenesis (GO:0060997) | 4.21313487 |
| 31 | auditory behavior (GO:0031223) | 4.16530307 |
| 32 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.15186567 |
| 33 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.15051074 |
| 34 | presynaptic membrane organization (GO:0097090) | 4.14850733 |
| 35 | neurotransmitter transport (GO:0006836) | 4.14640295 |
| 36 | synaptic transmission, glutamatergic (GO:0035249) | 4.06920405 |
| 37 | exploration behavior (GO:0035640) | 3.99498885 |
| 38 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.97896616 |
| 39 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.91901250 |
| 40 | presynaptic membrane assembly (GO:0097105) | 3.91095682 |
| 41 | L-amino acid import (GO:0043092) | 3.89922077 |
| 42 | regulation of synapse structural plasticity (GO:0051823) | 3.84733621 |
| 43 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.83673048 |
| 44 | regulation of neurotransmitter levels (GO:0001505) | 3.81427542 |
| 45 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.80796758 |
| 46 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.79726866 |
| 47 | potassium ion homeostasis (GO:0055075) | 3.79127591 |
| 48 | regulation of synapse maturation (GO:0090128) | 3.77312490 |
| 49 | glutamate receptor signaling pathway (GO:0007215) | 3.76474421 |
| 50 | transmission of nerve impulse (GO:0019226) | 3.74030175 |
| 51 | layer formation in cerebral cortex (GO:0021819) | 3.71953648 |
| 52 | neuron-neuron synaptic transmission (GO:0007270) | 3.71026803 |
| 53 | synaptic vesicle endocytosis (GO:0048488) | 3.70345315 |
| 54 | cellular sodium ion homeostasis (GO:0006883) | 3.61560240 |
| 55 | positive regulation of membrane potential (GO:0045838) | 3.61485613 |
| 56 | potassium ion import (GO:0010107) | 3.59421179 |
| 57 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.58575080 |
| 58 | positive regulation of dendritic spine development (GO:0060999) | 3.57219218 |
| 59 | regulation of neurotransmitter secretion (GO:0046928) | 3.57195600 |
| 60 | amino acid import (GO:0043090) | 3.56384732 |
| 61 | cell communication by electrical coupling (GO:0010644) | 3.51263339 |
| 62 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.50855338 |
| 63 | axonal fasciculation (GO:0007413) | 3.45107600 |
| 64 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.42910676 |
| 65 | neurotransmitter uptake (GO:0001504) | 3.42752409 |
| 66 | cell migration in hindbrain (GO:0021535) | 3.39628484 |
| 67 | response to auditory stimulus (GO:0010996) | 3.38086317 |
| 68 | mechanosensory behavior (GO:0007638) | 3.37653487 |
| 69 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.37106144 |
| 70 | regulation of postsynaptic membrane potential (GO:0060078) | 3.35775534 |
| 71 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.35376683 |
| 72 | neuromuscular process controlling balance (GO:0050885) | 3.33782942 |
| 73 | neuron recognition (GO:0008038) | 3.29562150 |
| 74 | regulation of neurotransmitter transport (GO:0051588) | 3.26985845 |
| 75 | membrane depolarization during action potential (GO:0086010) | 3.26245329 |
| 76 | cell differentiation in hindbrain (GO:0021533) | 3.24632190 |
| 77 | regulation of synaptic plasticity (GO:0048167) | 3.21983684 |
| 78 | long-term memory (GO:0007616) | 3.20787318 |
| 79 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.20467969 |
| 80 | establishment of mitochondrion localization (GO:0051654) | 3.16046889 |
| 81 | regulation of vesicle fusion (GO:0031338) | 3.14200114 |
| 82 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.13207277 |
| 83 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.11063666 |
| 84 | acidic amino acid transport (GO:0015800) | 3.07809936 |
| 85 | membrane depolarization (GO:0051899) | 3.07479898 |
| 86 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.06412449 |
| 87 | proline transport (GO:0015824) | 3.05754958 |
| 88 | neuromuscular synaptic transmission (GO:0007274) | 3.04507083 |
| 89 | dendritic spine organization (GO:0097061) | 3.02929425 |
| 90 | regulation of dendritic spine development (GO:0060998) | 3.02690987 |
| 91 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.01569200 |
| 92 | synaptic vesicle transport (GO:0048489) | 2.97541059 |
| 93 | establishment of synaptic vesicle localization (GO:0097480) | 2.97541059 |
| 94 | adult walking behavior (GO:0007628) | 2.97419734 |
| 95 | neuromuscular process controlling posture (GO:0050884) | 2.95239137 |
| 96 | synaptic transmission (GO:0007268) | 2.94707741 |
| 97 | positive regulation of neurotransmitter transport (GO:0051590) | 2.93772534 |
| 98 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.92885247 |
| 99 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.92883527 |
| 100 | C4-dicarboxylate transport (GO:0015740) | 2.90681982 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.58997592 |
| 2 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 4.10209709 |
| 3 | REST_21632747_ChIP-Seq_MESCs_Mouse | 3.08507393 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.04022290 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.98463038 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.96216911 |
| 7 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.80528332 |
| 8 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.78423881 |
| 9 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.70018800 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.65086645 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.65086645 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.64038581 |
| 13 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.52808014 |
| 14 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.52515865 |
| 15 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.49664839 |
| 16 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.46434556 |
| 17 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.43865386 |
| 18 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.43073660 |
| 19 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.41857580 |
| 20 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.38159483 |
| 21 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.37071805 |
| 22 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.36572826 |
| 23 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.34817350 |
| 24 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.31750610 |
| 25 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.08912314 |
| 26 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.04115654 |
| 27 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.88811450 |
| 28 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.83211636 |
| 29 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.74107580 |
| 30 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.67662677 |
| 31 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.63931157 |
| 32 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.57225689 |
| 33 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.56611406 |
| 34 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.48943466 |
| 35 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.48796027 |
| 36 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.46785553 |
| 37 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.46702827 |
| 38 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.46585491 |
| 39 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.44451219 |
| 40 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.38870550 |
| 41 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.37792358 |
| 42 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.37159840 |
| 43 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.36955809 |
| 44 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.36768795 |
| 45 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.30146799 |
| 46 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.26918859 |
| 47 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.25767203 |
| 48 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.24394501 |
| 49 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.23994607 |
| 50 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.23985348 |
| 51 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.21906694 |
| 52 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.19756873 |
| 53 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.19621421 |
| 54 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.18194642 |
| 55 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.17626104 |
| 56 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.17626104 |
| 57 | AR_19668381_ChIP-Seq_PC3_Human | 1.16607452 |
| 58 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.15966293 |
| 59 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.15249262 |
| 60 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.14323900 |
| 61 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.13904011 |
| 62 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.08546274 |
| 63 | KDM2B_26808549_Chip-Seq_K562_Human | 1.08494270 |
| 64 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.07380463 |
| 65 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06302224 |
| 66 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06195132 |
| 67 | P300_19829295_ChIP-Seq_ESCs_Human | 1.05639029 |
| 68 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.05063524 |
| 69 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.04722452 |
| 70 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.03917718 |
| 71 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.03465030 |
| 72 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.03341906 |
| 73 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.02688667 |
| 74 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.02397620 |
| 75 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.02273197 |
| 76 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.01144603 |
| 77 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.97523450 |
| 78 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.95072798 |
| 79 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.94753950 |
| 80 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.91758321 |
| 81 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.91217904 |
| 82 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.90991420 |
| 83 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.90904110 |
| 84 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.90624372 |
| 85 | TCF4_23295773_ChIP-Seq_U87_Human | 0.90410391 |
| 86 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.90298332 |
| 87 | STAT3_23295773_ChIP-Seq_U87_Human | 0.89744831 |
| 88 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89105488 |
| 89 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.88948795 |
| 90 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.88555316 |
| 91 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.87030375 |
| 92 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.86840451 |
| 93 | AR_25329375_ChIP-Seq_VCAP_Human | 0.86659803 |
| 94 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.86448896 |
| 95 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.85676897 |
| 96 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.83877519 |
| 97 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.83415564 |
| 98 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.83121357 |
| 99 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.82909721 |
| 100 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.80590039 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.53382742 |
| 2 | MP0003880_abnormal_central_pattern | 5.17955333 |
| 3 | MP0004270_analgesia | 3.91343912 |
| 4 | MP0005423_abnormal_somatic_nervous | 3.86901864 |
| 5 | MP0003635_abnormal_synaptic_transmissio | 3.58313118 |
| 6 | MP0002064_seizures | 3.22237153 |
| 7 | MP0009745_abnormal_behavioral_response | 2.99312868 |
| 8 | MP0002063_abnormal_learning/memory/cond | 2.95175254 |
| 9 | MP0009046_muscle_twitch | 2.86785334 |
| 10 | MP0001486_abnormal_startle_reflex | 2.82890978 |
| 11 | MP0002272_abnormal_nervous_system | 2.82021719 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.63980565 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.58207976 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.48616204 |
| 15 | MP0004885_abnormal_endolymph | 2.19927611 |
| 16 | MP0000778_abnormal_nervous_system | 2.19052904 |
| 17 | MP0008569_lethality_at_weaning | 2.18689001 |
| 18 | MP0001501_abnormal_sleep_pattern | 1.98678417 |
| 19 | MP0002735_abnormal_chemical_nociception | 1.97769015 |
| 20 | MP0002736_abnormal_nociception_after | 1.96320403 |
| 21 | MP0003122_maternal_imprinting | 1.96124741 |
| 22 | MP0003787_abnormal_imprinting | 1.85431303 |
| 23 | MP0003329_amyloid_beta_deposits | 1.83267517 |
| 24 | MP0001970_abnormal_pain_threshold | 1.82048736 |
| 25 | MP0003879_abnormal_hair_cell | 1.76691662 |
| 26 | MP0006276_abnormal_autonomic_nervous | 1.75646855 |
| 27 | MP0002557_abnormal_social/conspecific_i | 1.74411845 |
| 28 | MP0002067_abnormal_sensory_capabilities | 1.72780286 |
| 29 | MP0002733_abnormal_thermal_nociception | 1.71356074 |
| 30 | MP0003878_abnormal_ear_physiology | 1.67032384 |
| 31 | MP0005377_hearing/vestibular/ear_phenot | 1.67032384 |
| 32 | MP0001984_abnormal_olfaction | 1.66490171 |
| 33 | MP0001529_abnormal_vocalization | 1.63757669 |
| 34 | MP0001440_abnormal_grooming_behavior | 1.63040469 |
| 35 | MP0004811_abnormal_neuron_physiology | 1.62207643 |
| 36 | MP0002184_abnormal_innervation | 1.61498900 |
| 37 | MP0004742_abnormal_vestibular_system | 1.60153587 |
| 38 | MP0001502_abnormal_circadian_rhythm | 1.54459027 |
| 39 | MP0000955_abnormal_spinal_cord | 1.53013714 |
| 40 | MP0002882_abnormal_neuron_morphology | 1.50218548 |
| 41 | MP0004924_abnormal_behavior | 1.44635153 |
| 42 | MP0005386_behavior/neurological_phenoty | 1.44635153 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.42283608 |
| 44 | MP0000566_synostosis | 1.38982659 |
| 45 | MP0003633_abnormal_nervous_system | 1.37259472 |
| 46 | MP0002102_abnormal_ear_morphology | 1.30722272 |
| 47 | MP0001177_atelectasis | 1.29907189 |
| 48 | MP0003690_abnormal_glial_cell | 1.25183427 |
| 49 | MP0005646_abnormal_pituitary_gland | 1.24139650 |
| 50 | MP0002822_catalepsy | 1.21842850 |
| 51 | MP0003123_paternal_imprinting | 1.20102221 |
| 52 | MP0002152_abnormal_brain_morphology | 1.20051925 |
| 53 | MP0000920_abnormal_myelination | 1.19921010 |
| 54 | MP0003631_nervous_system_phenotype | 1.19742446 |
| 55 | MP0001963_abnormal_hearing_physiology | 1.16093988 |
| 56 | MP0006292_abnormal_olfactory_placode | 1.11180859 |
| 57 | MP0001485_abnormal_pinna_reflex | 1.10831774 |
| 58 | MP0005551_abnormal_eye_electrophysiolog | 1.10376649 |
| 59 | MP0002653_abnormal_ependyma_morphology | 1.07400703 |
| 60 | MP0001905_abnormal_dopamine_level | 1.06250444 |
| 61 | MP0002638_abnormal_pupillary_reflex | 1.06058997 |
| 62 | MP0001188_hyperpigmentation | 1.05728739 |
| 63 | MP0004142_abnormal_muscle_tone | 1.02270975 |
| 64 | MP0005499_abnormal_olfactory_system | 1.00561532 |
| 65 | MP0005394_taste/olfaction_phenotype | 1.00561532 |
| 66 | MP0009780_abnormal_chondrocyte_physiolo | 0.98725428 |
| 67 | MP0003121_genomic_imprinting | 0.97255750 |
| 68 | MP0003632_abnormal_nervous_system | 0.96453432 |
| 69 | MP0003634_abnormal_glial_cell | 0.95157296 |
| 70 | MP0001346_abnormal_lacrimal_gland | 0.94227507 |
| 71 | MP0002752_abnormal_somatic_nervous | 0.93391650 |
| 72 | MP0002229_neurodegeneration | 0.92266022 |
| 73 | MP0000569_abnormal_digit_pigmentation | 0.91163631 |
| 74 | MP0002909_abnormal_adrenal_gland | 0.90503270 |
| 75 | MP0000026_abnormal_inner_ear | 0.90448626 |
| 76 | MP0003938_abnormal_ear_development | 0.89237037 |
| 77 | MP0000579_abnormal_nail_morphology | 0.87029180 |
| 78 | MP0005248_abnormal_Harderian_gland | 0.81206833 |
| 79 | MP0003861_abnormal_nervous_system | 0.80105523 |
| 80 | MP0005645_abnormal_hypothalamus_physiol | 0.77721759 |
| 81 | MP0001299_abnormal_eye_distance/ | 0.77037581 |
| 82 | MP0002069_abnormal_eating/drinking_beha | 0.75340115 |
| 83 | MP0008877_abnormal_DNA_methylation | 0.74920437 |
| 84 | MP0004145_abnormal_muscle_electrophysio | 0.72950515 |
| 85 | MP0000631_abnormal_neuroendocrine_gland | 0.72630177 |
| 86 | MP0004147_increased_porphyrin_level | 0.72489001 |
| 87 | MP0005167_abnormal_blood-brain_barrier | 0.72354641 |
| 88 | MP0008872_abnormal_physiological_respon | 0.72241738 |
| 89 | MP0003137_abnormal_impulse_conducting | 0.69906930 |
| 90 | MP0006072_abnormal_retinal_apoptosis | 0.66827846 |
| 91 | MP0001986_abnormal_taste_sensitivity | 0.65438631 |
| 92 | MP0004858_abnormal_nervous_system | 0.65301201 |
| 93 | MP0005623_abnormal_meninges_morphology | 0.65071131 |
| 94 | MP0000604_amyloidosis | 0.64908865 |
| 95 | MP0004133_heterotaxia | 0.62953984 |
| 96 | MP0005253_abnormal_eye_physiology | 0.59317641 |
| 97 | MP0010769_abnormal_survival | 0.58502646 |
| 98 | MP0003283_abnormal_digestive_organ | 0.57631922 |
| 99 | MP0003119_abnormal_digestive_system | 0.57324109 |
| 100 | MP0010770_preweaning_lethality | 0.57032740 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.29896435 |
| 2 | Myokymia (HP:0002411) | 7.29879532 |
| 3 | Focal seizures (HP:0007359) | 5.80295263 |
| 4 | Febrile seizures (HP:0002373) | 5.23840896 |
| 5 | Atonic seizures (HP:0010819) | 5.04771144 |
| 6 | Epileptic encephalopathy (HP:0200134) | 4.77244166 |
| 7 | Action tremor (HP:0002345) | 4.52186608 |
| 8 | Supranuclear gaze palsy (HP:0000605) | 3.97758952 |
| 9 | Abnormality of binocular vision (HP:0011514) | 3.91308241 |
| 10 | Diplopia (HP:0000651) | 3.91308241 |
| 11 | Generalized tonic-clonic seizures (HP:0002069) | 3.89238967 |
| 12 | Abnormal eating behavior (HP:0100738) | 3.72294066 |
| 13 | Limb dystonia (HP:0002451) | 3.70687788 |
| 14 | Progressive cerebellar ataxia (HP:0002073) | 3.51847673 |
| 15 | Dialeptic seizures (HP:0011146) | 3.47052006 |
| 16 | Spastic gait (HP:0002064) | 3.46700420 |
| 17 | Absence seizures (HP:0002121) | 3.46587730 |
| 18 | Ankle clonus (HP:0011448) | 3.45765646 |
| 19 | Cerebral hypomyelination (HP:0006808) | 3.35412272 |
| 20 | Postural instability (HP:0002172) | 3.31611172 |
| 21 | Neurofibrillary tangles (HP:0002185) | 3.27819621 |
| 22 | Visual hallucinations (HP:0002367) | 3.09920391 |
| 23 | Status epilepticus (HP:0002133) | 3.03010378 |
| 24 | Annular pancreas (HP:0001734) | 3.02788797 |
| 25 | Aplasia involving bones of the extremities (HP:0009825) | 2.95523682 |
| 26 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.95523682 |
| 27 | Aplasia of the phalanges of the hand (HP:0009802) | 2.95523682 |
| 28 | Abnormality of the corticospinal tract (HP:0002492) | 2.94796115 |
| 29 | Polyphagia (HP:0002591) | 2.88386442 |
| 30 | Hemiparesis (HP:0001269) | 2.87312036 |
| 31 | Abnormality of the lower motor neuron (HP:0002366) | 2.84365481 |
| 32 | Torticollis (HP:0000473) | 2.79977581 |
| 33 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.76349128 |
| 34 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.76176772 |
| 35 | Dysmetria (HP:0001310) | 2.75932804 |
| 36 | Sleep apnea (HP:0010535) | 2.75173695 |
| 37 | Hemiplegia (HP:0002301) | 2.70703521 |
| 38 | Urinary urgency (HP:0000012) | 2.62953278 |
| 39 | Epileptiform EEG discharges (HP:0011182) | 2.59214707 |
| 40 | Mutism (HP:0002300) | 2.58745034 |
| 41 | Akinesia (HP:0002304) | 2.58587933 |
| 42 | Intention tremor (HP:0002080) | 2.55202726 |
| 43 | Truncal ataxia (HP:0002078) | 2.49502038 |
| 44 | Tetraplegia (HP:0002445) | 2.44527496 |
| 45 | Amblyopia (HP:0000646) | 2.44401600 |
| 46 | Papilledema (HP:0001085) | 2.41974645 |
| 47 | Gait imbalance (HP:0002141) | 2.39999010 |
| 48 | Abnormality of the labia minora (HP:0012880) | 2.37217959 |
| 49 | Focal dystonia (HP:0004373) | 2.35805266 |
| 50 | Poor eye contact (HP:0000817) | 2.35157588 |
| 51 | Cerebral inclusion bodies (HP:0100314) | 2.34115077 |
| 52 | EEG with generalized epileptiform discharges (HP:0011198) | 2.33236989 |
| 53 | Anxiety (HP:0000739) | 2.28042077 |
| 54 | Depression (HP:0000716) | 2.27584033 |
| 55 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.27043559 |
| 56 | Obstructive sleep apnea (HP:0002870) | 2.26594450 |
| 57 | Dysdiadochokinesis (HP:0002075) | 2.26209243 |
| 58 | CNS hypomyelination (HP:0003429) | 2.25602537 |
| 59 | Alacrima (HP:0000522) | 2.25502528 |
| 60 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.25060051 |
| 61 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.25060051 |
| 62 | Bradykinesia (HP:0002067) | 2.24760898 |
| 63 | Delusions (HP:0000746) | 2.24752000 |
| 64 | Lower limb muscle weakness (HP:0007340) | 2.24222061 |
| 65 | Peripheral hypomyelination (HP:0007182) | 2.23487872 |
| 66 | Hypsarrhythmia (HP:0002521) | 2.22707962 |
| 67 | Megalencephaly (HP:0001355) | 2.22596082 |
| 68 | Broad-based gait (HP:0002136) | 2.16183717 |
| 69 | Drooling (HP:0002307) | 2.14929181 |
| 70 | Abnormal social behavior (HP:0012433) | 2.12820359 |
| 71 | Impaired social interactions (HP:0000735) | 2.12820359 |
| 72 | Specific learning disability (HP:0001328) | 2.10313608 |
| 73 | Craniofacial dystonia (HP:0012179) | 2.06197517 |
| 74 | Impaired smooth pursuit (HP:0007772) | 2.02087077 |
| 75 | Partial duplication of thumb phalanx (HP:0009944) | 2.01370312 |
| 76 | Amyotrophic lateral sclerosis (HP:0007354) | 2.00949788 |
| 77 | Scanning speech (HP:0002168) | 2.00598087 |
| 78 | Clonus (HP:0002169) | 1.95500503 |
| 79 | Spastic tetraparesis (HP:0001285) | 1.95498333 |
| 80 | Excessive salivation (HP:0003781) | 1.93643884 |
| 81 | Gaze-evoked nystagmus (HP:0000640) | 1.91841860 |
| 82 | Neuronal loss in central nervous system (HP:0002529) | 1.90135324 |
| 83 | Failure to thrive in infancy (HP:0001531) | 1.89426434 |
| 84 | Incomplete penetrance (HP:0003829) | 1.89296168 |
| 85 | Turricephaly (HP:0000262) | 1.87086654 |
| 86 | Partial duplication of the phalanx of hand (HP:0009999) | 1.86851535 |
| 87 | Choreoathetosis (HP:0001266) | 1.86567569 |
| 88 | Poor suck (HP:0002033) | 1.81880534 |
| 89 | Decreased lacrimation (HP:0000633) | 1.80006700 |
| 90 | Rapidly progressive (HP:0003678) | 1.79354131 |
| 91 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.78371011 |
| 92 | Increased circulating renin level (HP:0000848) | 1.78088798 |
| 93 | Apathy (HP:0000741) | 1.77547782 |
| 94 | Lower limb asymmetry (HP:0100559) | 1.75938511 |
| 95 | Stereotypic behavior (HP:0000733) | 1.74653870 |
| 96 | Dyskinesia (HP:0100660) | 1.74314091 |
| 97 | Mixed hearing impairment (HP:0000410) | 1.74210587 |
| 98 | Congenital primary aphakia (HP:0007707) | 1.73756055 |
| 99 | Spastic tetraplegia (HP:0002510) | 1.73562716 |
| 100 | Impaired vibratory sensation (HP:0002495) | 1.72388729 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.72168768 |
| 2 | MARK1 | 4.43564132 |
| 3 | NTRK3 | 3.66116010 |
| 4 | PAK6 | 3.28330453 |
| 5 | DAPK2 | 3.27759007 |
| 6 | NTRK2 | 3.12560375 |
| 7 | CASK | 2.81812048 |
| 8 | UHMK1 | 2.73089764 |
| 9 | MAP3K9 | 2.48200931 |
| 10 | MINK1 | 2.36859760 |
| 11 | PRKD3 | 2.33945098 |
| 12 | CAMKK1 | 2.23865539 |
| 13 | MAPK13 | 2.08076644 |
| 14 | NTRK1 | 2.01243751 |
| 15 | PINK1 | 1.87803335 |
| 16 | RIPK1 | 1.77407535 |
| 17 | CDK19 | 1.73451348 |
| 18 | PLK2 | 1.72009463 |
| 19 | CAMKK2 | 1.55878694 |
| 20 | GRK5 | 1.55250407 |
| 21 | CDK5 | 1.49179570 |
| 22 | PRKCG | 1.48788888 |
| 23 | CAMK2B | 1.46958973 |
| 24 | CAMK1 | 1.46795745 |
| 25 | MAP3K4 | 1.45094589 |
| 26 | SGK223 | 1.43741552 |
| 27 | SGK494 | 1.43741552 |
| 28 | ARAF | 1.38970304 |
| 29 | SIK2 | 1.34734638 |
| 30 | FGFR2 | 1.33990702 |
| 31 | TYRO3 | 1.29367465 |
| 32 | DYRK1A | 1.28709117 |
| 33 | PHKG2 | 1.27831812 |
| 34 | PHKG1 | 1.27831812 |
| 35 | LATS2 | 1.19050123 |
| 36 | TNIK | 1.17789407 |
| 37 | CDK15 | 1.12769949 |
| 38 | PAK3 | 1.12042657 |
| 39 | CDK18 | 1.11422185 |
| 40 | PKN1 | 1.07241480 |
| 41 | PRKCH | 1.04914789 |
| 42 | CDK11A | 1.04233921 |
| 43 | SGK2 | 1.04204476 |
| 44 | STK11 | 1.04081599 |
| 45 | KSR2 | 1.03804237 |
| 46 | DAPK1 | 1.01218983 |
| 47 | CDK14 | 1.00981842 |
| 48 | CAMK2A | 1.00602194 |
| 49 | DYRK2 | 0.88024291 |
| 50 | OXSR1 | 0.82431977 |
| 51 | MAP2K7 | 0.79722213 |
| 52 | CAMK2G | 0.79000584 |
| 53 | MARK2 | 0.77720183 |
| 54 | SGK3 | 0.75520699 |
| 55 | STK38 | 0.75262305 |
| 56 | CSNK1G2 | 0.73133610 |
| 57 | KSR1 | 0.72373825 |
| 58 | SGK1 | 0.70981389 |
| 59 | CAMK4 | 0.70585034 |
| 60 | MAP2K4 | 0.69346399 |
| 61 | PNCK | 0.65540216 |
| 62 | ROCK2 | 0.63778637 |
| 63 | NEK6 | 0.62641327 |
| 64 | ALK | 0.62130590 |
| 65 | PRKCZ | 0.61930562 |
| 66 | BRSK1 | 0.61916558 |
| 67 | MAPK10 | 0.57700098 |
| 68 | BCR | 0.55978006 |
| 69 | CAMK2D | 0.55907330 |
| 70 | RPS6KA3 | 0.54312987 |
| 71 | WNK1 | 0.53713805 |
| 72 | LMTK2 | 0.52175917 |
| 73 | WNK3 | 0.50523594 |
| 74 | ERBB2 | 0.48365888 |
| 75 | MAPKAPK5 | 0.45037630 |
| 76 | MAPK12 | 0.43685096 |
| 77 | MAPK15 | 0.43656650 |
| 78 | BRAF | 0.42780969 |
| 79 | PRKCE | 0.40693435 |
| 80 | DAPK3 | 0.39561592 |
| 81 | PRKACA | 0.38810681 |
| 82 | RAF1 | 0.36341602 |
| 83 | CSNK1G3 | 0.35351227 |
| 84 | LIMK1 | 0.35028399 |
| 85 | FYN | 0.34052290 |
| 86 | PRKG1 | 0.33669151 |
| 87 | DYRK1B | 0.33647897 |
| 88 | PRKCA | 0.33170526 |
| 89 | ROCK1 | 0.33050751 |
| 90 | CSNK1E | 0.31956245 |
| 91 | CSNK1A1L | 0.31656335 |
| 92 | CSNK1D | 0.30559489 |
| 93 | PDK1 | 0.30509407 |
| 94 | MOS | 0.30005304 |
| 95 | MAPK8 | 0.29317619 |
| 96 | MAP3K13 | 0.28621940 |
| 97 | CSNK1G1 | 0.26796212 |
| 98 | RET | 0.26548763 |
| 99 | DMPK | 0.26178374 |
| 100 | CSNK1A1 | 0.25963421 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.57052287 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.79100842 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.90744573 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.77852988 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.72775855 |
| 6 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.67002673 |
| 7 | Morphine addiction_Homo sapiens_hsa05032 | 2.64798866 |
| 8 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.64330725 |
| 9 | Long-term potentiation_Homo sapiens_hsa04720 | 2.57482007 |
| 10 | Insulin secretion_Homo sapiens_hsa04911 | 2.40977633 |
| 11 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.35371468 |
| 12 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.10503825 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.09687338 |
| 14 | Cocaine addiction_Homo sapiens_hsa05030 | 2.08036301 |
| 15 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.90387855 |
| 16 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.87077169 |
| 17 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.79142163 |
| 18 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.71313078 |
| 19 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.71153107 |
| 20 | Salivary secretion_Homo sapiens_hsa04970 | 1.68630146 |
| 21 | Taste transduction_Homo sapiens_hsa04742 | 1.64300589 |
| 22 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.50688463 |
| 23 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.44053040 |
| 24 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.38510953 |
| 25 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.37986849 |
| 26 | Renin secretion_Homo sapiens_hsa04924 | 1.36274076 |
| 27 | Long-term depression_Homo sapiens_hsa04730 | 1.35044143 |
| 28 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.30935056 |
| 29 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.29172427 |
| 30 | Olfactory transduction_Homo sapiens_hsa04740 | 1.22447244 |
| 31 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.20390379 |
| 32 | Axon guidance_Homo sapiens_hsa04360 | 1.20065472 |
| 33 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.17156315 |
| 34 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.16882022 |
| 35 | Gap junction_Homo sapiens_hsa04540 | 1.13978894 |
| 36 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.11022209 |
| 37 | Phototransduction_Homo sapiens_hsa04744 | 1.10839457 |
| 38 | Melanogenesis_Homo sapiens_hsa04916 | 1.07532786 |
| 39 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.04598766 |
| 40 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.03481411 |
| 41 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.03060026 |
| 42 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.00829301 |
| 43 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.98585389 |
| 44 | Bile secretion_Homo sapiens_hsa04976 | 0.98379622 |
| 45 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.94971743 |
| 46 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.91139909 |
| 47 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.90491911 |
| 48 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.88300332 |
| 49 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.84924878 |
| 50 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.84684382 |
| 51 | Circadian rhythm_Homo sapiens_hsa04710 | 0.81221076 |
| 52 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.72878274 |
| 53 | Glioma_Homo sapiens_hsa05214 | 0.71816775 |
| 54 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.70795412 |
| 55 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.68399682 |
| 56 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.68029593 |
| 57 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.67933217 |
| 58 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.65848027 |
| 59 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.64903233 |
| 60 | Alzheimers disease_Homo sapiens_hsa05010 | 0.64030333 |
| 61 | Histidine metabolism_Homo sapiens_hsa00340 | 0.62182557 |
| 62 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.60609957 |
| 63 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.60475408 |
| 64 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.59205838 |
| 65 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.58820218 |
| 66 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.56506675 |
| 67 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.55515465 |
| 68 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.55381729 |
| 69 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.53914244 |
| 70 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.53217071 |
| 71 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.52373697 |
| 72 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.51192268 |
| 73 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.49774658 |
| 74 | Prion diseases_Homo sapiens_hsa05020 | 0.48443035 |
| 75 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.47899005 |
| 76 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47255759 |
| 77 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.47157366 |
| 78 | Alcoholism_Homo sapiens_hsa05034 | 0.45869811 |
| 79 | Tight junction_Homo sapiens_hsa04530 | 0.43164662 |
| 80 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.42391187 |
| 81 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.41797834 |
| 82 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.40758142 |
| 83 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.40669943 |
| 84 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.40507707 |
| 85 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.40266496 |
| 86 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.39939550 |
| 87 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.38450606 |
| 88 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.37486067 |
| 89 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.36143262 |
| 90 | Parkinsons disease_Homo sapiens_hsa05012 | 0.32905352 |
| 91 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.30899572 |
| 92 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.29229851 |
| 93 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.28961033 |
| 94 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.28246632 |
| 95 | Endocytosis_Homo sapiens_hsa04144 | 0.28047625 |
| 96 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.27799865 |
| 97 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.27723283 |
| 98 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.26990559 |
| 99 | Mineral absorption_Homo sapiens_hsa04978 | 0.25811688 |
| 100 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.25658250 |

