TMEM178B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42235688
2vocalization behavior (GO:0071625)5.33600183
3neuron cell-cell adhesion (GO:0007158)5.32378576
4synaptic vesicle maturation (GO:0016188)5.12164303
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06511314
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.00166534
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99676399
8locomotory exploration behavior (GO:0035641)4.96600142
9synaptic vesicle exocytosis (GO:0016079)4.93959440
10glutamate secretion (GO:0014047)4.67669471
11pyrimidine nucleobase catabolic process (GO:0006208)4.66340647
12protein localization to synapse (GO:0035418)4.61514082
13regulation of synaptic vesicle exocytosis (GO:2000300)4.60728890
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.51039371
15regulation of glutamate receptor signaling pathway (GO:1900449)4.50682270
16dendritic spine morphogenesis (GO:0060997)4.28938766
17layer formation in cerebral cortex (GO:0021819)4.21775888
18exploration behavior (GO:0035640)4.13882100
19neuron recognition (GO:0008038)4.07842230
20glutamate receptor signaling pathway (GO:0007215)4.07453346
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.05833558
22presynaptic membrane assembly (GO:0097105)4.04337419
23neuronal action potential propagation (GO:0019227)4.02642715
24regulation of synaptic vesicle transport (GO:1902803)4.00290129
25synaptic transmission, glutamatergic (GO:0035249)3.96441337
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.95607628
27regulation of neuronal synaptic plasticity (GO:0048168)3.94666480
28neurotransmitter secretion (GO:0007269)3.94324745
29nucleobase catabolic process (GO:0046113)3.93601773
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87690395
31presynaptic membrane organization (GO:0097090)3.86575676
32gamma-aminobutyric acid transport (GO:0015812)3.85289043
33neuron-neuron synaptic transmission (GO:0007270)3.83965636
34postsynaptic membrane organization (GO:0001941)3.70382612
35neurotransmitter-gated ion channel clustering (GO:0072578)3.69871597
36axonal fasciculation (GO:0007413)3.68156027
37regulation of synapse structural plasticity (GO:0051823)3.66973648
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57406425
39transmission of nerve impulse (GO:0019226)3.56568725
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54702707
41dendrite morphogenesis (GO:0048813)3.53121200
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.51924901
43long-term memory (GO:0007616)3.47610987
44proline transport (GO:0015824)3.47558264
45positive regulation of membrane potential (GO:0045838)3.45158055
46regulation of postsynaptic membrane potential (GO:0060078)3.42595615
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42499913
48neurotransmitter transport (GO:0006836)3.40765389
49regulation of dendritic spine morphogenesis (GO:0061001)3.32440132
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31390425
51auditory behavior (GO:0031223)3.30900686
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28561611
53axon ensheathment in central nervous system (GO:0032291)3.27906623
54central nervous system myelination (GO:0022010)3.27906623
55cellular potassium ion homeostasis (GO:0030007)3.27498624
56regulation of neurotransmitter secretion (GO:0046928)3.25217834
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23461363
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.21890900
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21876715
60synapse assembly (GO:0007416)3.21375283
61synaptic vesicle endocytosis (GO:0048488)3.21226237
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20561931
63regulation of synaptic plasticity (GO:0048167)3.20394431
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.19738613
65negative regulation of neurotransmitter transport (GO:0051589)3.16958604
66cerebellar granule cell differentiation (GO:0021707)3.16847560
67long-term synaptic potentiation (GO:0060291)3.16822298
68central nervous system projection neuron axonogenesis (GO:0021952)3.14957414
69response to auditory stimulus (GO:0010996)3.14818416
70membrane hyperpolarization (GO:0060081)3.13363894
71glycine transport (GO:0015816)3.13235277
72establishment of mitochondrion localization (GO:0051654)3.13010031
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12760746
74positive regulation of synapse maturation (GO:0090129)3.11146829
75regulation of vesicle fusion (GO:0031338)3.10117640
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09331100
77regulation of neurotransmitter levels (GO:0001505)3.07739150
78adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.07139594
79cell migration in hindbrain (GO:0021535)3.06212533
80adult walking behavior (GO:0007628)3.03875350
81negative regulation of cytosolic calcium ion concentration (GO:0051481)3.03156699
82regulation of neurotransmitter transport (GO:0051588)3.02372769
83neuronal ion channel clustering (GO:0045161)3.02291218
84detection of calcium ion (GO:0005513)3.00536060
85neuromuscular synaptic transmission (GO:0007274)3.00510721
86cerebellar Purkinje cell differentiation (GO:0021702)2.98916156
87learning (GO:0007612)2.98829684
88cell communication by electrical coupling (GO:0010644)2.98813862
89regulation of dendritic spine development (GO:0060998)2.97325056
90startle response (GO:0001964)2.97067509
91L-amino acid import (GO:0043092)2.97050329
92membrane depolarization (GO:0051899)2.96249592
93dendritic spine organization (GO:0097061)2.95466849
94organelle transport along microtubule (GO:0072384)2.95318998
95neuromuscular process controlling balance (GO:0050885)2.94773627
96activation of protein kinase A activity (GO:0034199)2.91072890
97mechanosensory behavior (GO:0007638)2.90625326
98positive regulation of neurotransmitter secretion (GO:0001956)2.90552015
99synapse organization (GO:0050808)2.89632744
100vesicle transport along microtubule (GO:0047496)2.89548616
101response to histamine (GO:0034776)2.89469874
102innervation (GO:0060384)2.89245347
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87725830
104positive regulation of synapse assembly (GO:0051965)2.87406389
105mating behavior (GO:0007617)2.86249411
106mitochondrion transport along microtubule (GO:0047497)2.85796482
107establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85796482
108regulation of respiratory system process (GO:0044065)2.85011651
109prepulse inhibition (GO:0060134)2.84611425
110cochlea development (GO:0090102)2.84266593
111cell communication involved in cardiac conduction (GO:0086065)2.83693007
112central nervous system neuron axonogenesis (GO:0021955)2.83092821
113membrane depolarization during action potential (GO:0086010)2.83054060
114positive regulation of dendritic spine development (GO:0060999)2.80251196
115behavioral response to nicotine (GO:0035095)2.79000385
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.75881986
117axon extension (GO:0048675)2.75375860
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.74387401
119sodium ion export (GO:0071436)2.74191672
120negative regulation of dendrite development (GO:2000171)2.72808782
121multicellular organismal signaling (GO:0035637)2.69884121
122regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.66292768
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.66047500
124regulation of synapse assembly (GO:0051963)2.63954250
125regulation of membrane repolarization (GO:0060306)2.63498740
126atrial cardiac muscle cell action potential (GO:0086014)2.61117221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76872620
2GBX2_23144817_ChIP-Seq_PC3_Human3.84910212
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02774129
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99746255
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92542598
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56480677
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56480677
8REST_21632747_ChIP-Seq_MESCs_Mouse2.53307930
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.51541798
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48873557
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46992368
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44228100
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39332804
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38744925
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38254748
16DROSHA_22980978_ChIP-Seq_HELA_Human2.26677737
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.25729662
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20282676
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.19089155
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17842534
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.11915041
22TAF15_26573619_Chip-Seq_HEK293_Human2.11722242
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.11040168
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99371151
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.96795315
26AR_21572438_ChIP-Seq_LNCaP_Human1.95945980
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92914599
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89746538
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88411343
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79025304
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78684310
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66043496
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65782138
34SMAD4_21799915_ChIP-Seq_A2780_Human1.64082917
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63353146
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61188208
37P300_19829295_ChIP-Seq_ESCs_Human1.54015118
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50334682
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50056469
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.47551692
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.47104913
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46118177
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41684837
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41165813
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40373477
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39817333
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39455394
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38718571
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38417186
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35081838
51IGF1R_20145208_ChIP-Seq_DFB_Human1.34162785
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32636183
53ZNF274_21170338_ChIP-Seq_K562_Hela1.32359215
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.32114441
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.31172111
56STAT3_23295773_ChIP-Seq_U87_Human1.30968583
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30157750
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29544458
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28747250
60AR_25329375_ChIP-Seq_VCAP_Human1.26252012
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.25733913
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.25531226
63RNF2_27304074_Chip-Seq_NSC_Mouse1.25504968
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.25059589
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23712552
66FUS_26573619_Chip-Seq_HEK293_Human1.20545023
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17541382
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15415035
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15304276
70TCF4_23295773_ChIP-Seq_U87_Human1.15196556
71ER_23166858_ChIP-Seq_MCF-7_Human1.12815208
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.12379835
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.11774301
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11074547
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10633434
76AR_19668381_ChIP-Seq_PC3_Human1.10421690
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09206743
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07936260
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07559586
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07294974
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.06769248
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06696870
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06645403
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06637114
85SOX9_26525672_Chip-Seq_HEART_Mouse1.06360283
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05823057
87RUNX2_22187159_ChIP-Seq_PCA_Human1.05804452
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04774280
89AHR_22903824_ChIP-Seq_MCF-7_Human1.04550535
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.03953448
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03273240
92VDR_22108803_ChIP-Seq_LS180_Human1.02156540
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01689609
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01669292
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01669292
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01569102
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01377562
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01250513
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98762468
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.97156519
101JUN_21703547_ChIP-Seq_K562_Human0.96387714
102SALL1_21062744_ChIP-ChIP_HESCs_Human0.94851694
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.94490827
104TP53_16413492_ChIP-PET_HCT116_Human0.94471894
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92323893
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.91202422
107TP53_18474530_ChIP-ChIP_U2OS_Human0.89248670
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89033852
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.88768964
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88474089
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87427124
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.84835275
113KDM2B_26808549_Chip-Seq_REH_Human0.84549102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.64824670
2MP0003880_abnormal_central_pattern4.87831721
3MP0004270_analgesia3.97156752
4MP0003635_abnormal_synaptic_transmissio3.86870359
5MP0005423_abnormal_somatic_nervous3.32291129
6MP0009745_abnormal_behavioral_response3.27617521
7MP0002063_abnormal_learning/memory/cond3.13651921
8MP0002064_seizures3.05976474
9MP0009046_muscle_twitch2.92727868
10MP0001968_abnormal_touch/_nociception2.84577898
11MP0002734_abnormal_mechanical_nocicepti2.78859500
12MP0002572_abnormal_emotion/affect_behav2.74829289
13MP0001486_abnormal_startle_reflex2.73249231
14MP0002272_abnormal_nervous_system2.60935305
15MP0000778_abnormal_nervous_system2.29927544
16MP0002735_abnormal_chemical_nociception2.29711668
17MP0001440_abnormal_grooming_behavior2.17040787
18MP0002822_catalepsy2.15048172
19MP0002736_abnormal_nociception_after2.13445046
20MP0002733_abnormal_thermal_nociception2.09235989
21MP0001501_abnormal_sleep_pattern2.04000893
22MP0001970_abnormal_pain_threshold2.03053633
23MP0003329_amyloid_beta_deposits2.01944816
24MP0002067_abnormal_sensory_capabilities1.98235269
25MP0002184_abnormal_innervation1.94887376
26MP0006276_abnormal_autonomic_nervous1.88692923
27MP0005386_behavior/neurological_phenoty1.85750014
28MP0004924_abnormal_behavior1.85750014
29MP0009780_abnormal_chondrocyte_physiolo1.81305282
30MP0002557_abnormal_social/conspecific_i1.80413126
31MP0001529_abnormal_vocalization1.80055355
32MP0008569_lethality_at_weaning1.74499669
33MP0004885_abnormal_endolymph1.72901964
34MP0005645_abnormal_hypothalamus_physiol1.69055167
35MP0000955_abnormal_spinal_cord1.67714500
36MP0004811_abnormal_neuron_physiology1.66931936
37MP0005646_abnormal_pituitary_gland1.58477403
38MP0001905_abnormal_dopamine_level1.58327006
39MP0001984_abnormal_olfaction1.56342533
40MP0003121_genomic_imprinting1.55754771
41MP0004858_abnormal_nervous_system1.55720563
42MP0002882_abnormal_neuron_morphology1.53198049
43MP0000920_abnormal_myelination1.53173512
44MP0003879_abnormal_hair_cell1.50395099
45MP0004742_abnormal_vestibular_system1.49974924
46MP0002066_abnormal_motor_capabilities/c1.47256750
47MP0004142_abnormal_muscle_tone1.44251725
48MP0002909_abnormal_adrenal_gland1.38548097
49MP0003633_abnormal_nervous_system1.36464571
50MP0003787_abnormal_imprinting1.32550049
51MP0001188_hyperpigmentation1.27804247
52MP0001502_abnormal_circadian_rhythm1.24940309
53MP0003631_nervous_system_phenotype1.21356467
54MP0003136_yellow_coat_color1.18650729
55MP0002229_neurodegeneration1.18392196
56MP0002152_abnormal_brain_morphology1.18046287
57MP0005551_abnormal_eye_electrophysiolog1.16618465
58MP0003634_abnormal_glial_cell1.15939856
59MP0003283_abnormal_digestive_organ1.15638277
60MP0003690_abnormal_glial_cell1.10816327
61MP0002234_abnormal_pharynx_morphology1.10456940
62MP0004133_heterotaxia1.07370531
63MP0003122_maternal_imprinting1.07012468
64MP0005187_abnormal_penis_morphology1.05808872
65MP0001485_abnormal_pinna_reflex1.05407432
66MP0005409_darkened_coat_color1.05104022
67MP0000566_synostosis1.04226502
68MP0001963_abnormal_hearing_physiology1.01270726
69MP0008877_abnormal_DNA_methylation1.01167360
70MP0010386_abnormal_urinary_bladder1.00741735
71MP0004215_abnormal_myocardial_fiber0.96682626
72MP0003632_abnormal_nervous_system0.96594190
73MP0000631_abnormal_neuroendocrine_gland0.96569085
74MP0002752_abnormal_somatic_nervous0.95558722
75MP0003123_paternal_imprinting0.92858037
76MP0002069_abnormal_eating/drinking_beha0.90656577
77MP0004145_abnormal_muscle_electrophysio0.88586817
78MP0001177_atelectasis0.87258796
79MP0000604_amyloidosis0.85945171
80MP0003938_abnormal_ear_development0.82671993
81MP0003890_abnormal_embryonic-extraembry0.82116325
82MP0004085_abnormal_heartbeat0.81021852
83MP0000569_abnormal_digit_pigmentation0.80934042
84MP0008872_abnormal_physiological_respon0.79758204
85MP0006292_abnormal_olfactory_placode0.78797418
86MP0001299_abnormal_eye_distance/0.76510055
87MP0005499_abnormal_olfactory_system0.76399876
88MP0005394_taste/olfaction_phenotype0.76399876
89MP0000534_abnormal_ureter_morphology0.75571250
90MP0008874_decreased_physiological_sensi0.75107184
91MP0003119_abnormal_digestive_system0.74903903
92MP0004043_abnormal_pH_regulation0.71941716
93MP0000751_myopathy0.71620156
94MP0002090_abnormal_vision0.70279099
95MP0005535_abnormal_body_temperature0.69937505
96MP0003861_abnormal_nervous_system0.68180468
97MP0002081_perinatal_lethality0.67757344
98MP0005171_absent_coat_pigmentation0.67250384
99MP0002653_abnormal_ependyma_morphology0.67152076
100MP0002638_abnormal_pupillary_reflex0.67023737
101MP0006072_abnormal_retinal_apoptosis0.66254939
102MP0000013_abnormal_adipose_tissue0.65829259
103MP0000026_abnormal_inner_ear0.65796009
104MP0002938_white_spotting0.65050138
105MP0001664_abnormal_digestion0.63529927
106MP0003137_abnormal_impulse_conducting0.60048665
107MP0001943_abnormal_respiration0.58638388
108MP0010770_preweaning_lethality0.55571156
109MP0002082_postnatal_lethality0.55571156
110MP0010769_abnormal_survival0.55472160
111MP0002837_dystrophic_cardiac_calcinosis0.54952780
112MP0001348_abnormal_lacrimal_gland0.54859245
113MP0005253_abnormal_eye_physiology0.53056059
114MP0010768_mortality/aging0.51886350
115MP0004484_altered_response_of0.50643332
116MP0002876_abnormal_thyroid_physiology0.50382333
117MP0005410_abnormal_fertilization0.49635614
118MP0002751_abnormal_autonomic_nervous0.48908678

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.93009962
2Myokymia (HP:0002411)5.97331417
3Focal seizures (HP:0007359)5.26131180
4Epileptic encephalopathy (HP:0200134)4.75934294
5Visual hallucinations (HP:0002367)4.65944360
6Supranuclear gaze palsy (HP:0000605)4.14242375
7Progressive cerebellar ataxia (HP:0002073)4.01089286
8Atonic seizures (HP:0010819)3.97454716
9Absence seizures (HP:0002121)3.95214592
10Neurofibrillary tangles (HP:0002185)3.85376944
11Febrile seizures (HP:0002373)3.80768173
12Dialeptic seizures (HP:0011146)3.65959800
13Hyperventilation (HP:0002883)3.65432783
14Ankle clonus (HP:0011448)3.62925754
15Broad-based gait (HP:0002136)3.61897756
16Abnormality of the corticospinal tract (HP:0002492)3.58593827
17Generalized tonic-clonic seizures (HP:0002069)3.51063671
18Action tremor (HP:0002345)3.47248223
19Cerebral inclusion bodies (HP:0100314)3.43513467
20Limb dystonia (HP:0002451)3.23866272
21Mutism (HP:0002300)3.22172248
22Poor eye contact (HP:0000817)3.18780342
23Insidious onset (HP:0003587)3.10439742
24Termporal pattern (HP:0011008)3.10439742
25Dysmetria (HP:0001310)3.09214547
26Drooling (HP:0002307)3.08130829
27Excessive salivation (HP:0003781)3.08130829
28Degeneration of the lateral corticospinal tracts (HP:0002314)3.05431714
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.05431714
30Spastic gait (HP:0002064)2.99220093
31Urinary bladder sphincter dysfunction (HP:0002839)2.92405454
32Gaze-evoked nystagmus (HP:0000640)2.87607218
33Truncal ataxia (HP:0002078)2.84310008
34Abnormal social behavior (HP:0012433)2.83501326
35Impaired social interactions (HP:0000735)2.83501326
36Progressive inability to walk (HP:0002505)2.80272281
37Dysdiadochokinesis (HP:0002075)2.74906008
38Impaired vibration sensation in the lower limbs (HP:0002166)2.74396922
39Papilledema (HP:0001085)2.72235045
40Anxiety (HP:0000739)2.68390731
41Abnormal eating behavior (HP:0100738)2.67974542
42Amblyopia (HP:0000646)2.66572953
43Scanning speech (HP:0002168)2.65035876
44Depression (HP:0000716)2.64159818
45Urinary urgency (HP:0000012)2.64088185
46Hemiparesis (HP:0001269)2.61228831
47Epileptiform EEG discharges (HP:0011182)2.59859435
48Intention tremor (HP:0002080)2.59387844
49Pheochromocytoma (HP:0002666)2.59293895
50Akinesia (HP:0002304)2.53775640
51EEG with generalized epileptiform discharges (HP:0011198)2.52280187
52Abnormality of binocular vision (HP:0011514)2.48323509
53Diplopia (HP:0000651)2.48323509
54Postural instability (HP:0002172)2.47862242
55Absent speech (HP:0001344)2.47827348
56Fetal akinesia sequence (HP:0001989)2.44253372
57Megalencephaly (HP:0001355)2.42682295
58Genetic anticipation (HP:0003743)2.42503827
59Inability to walk (HP:0002540)2.42085536
60Lower limb muscle weakness (HP:0007340)2.40294276
61Hepatoblastoma (HP:0002884)2.39315359
62Hypsarrhythmia (HP:0002521)2.38917495
63Torticollis (HP:0000473)2.36616070
64Syncope (HP:0001279)2.36357542
65Bundle branch block (HP:0011710)2.34706609
66Polyphagia (HP:0002591)2.28775806
67Retinal dysplasia (HP:0007973)2.27097688
68Generalized myoclonic seizures (HP:0002123)2.24574353
69Sleep apnea (HP:0010535)2.24093097
70Amyotrophic lateral sclerosis (HP:0007354)2.22411109
71Agitation (HP:0000713)2.22045388
72Stereotypic behavior (HP:0000733)2.17651205
73Neuroendocrine neoplasm (HP:0100634)2.16901064
74Peripheral hypomyelination (HP:0007182)2.16719795
75Focal dystonia (HP:0004373)2.14518943
76Blue irides (HP:0000635)2.13552743
77Abnormality of salivation (HP:0100755)2.13090563
78Gait imbalance (HP:0002141)2.10446658
79Sudden death (HP:0001699)2.07837959
80Bradykinesia (HP:0002067)2.05649834
81Status epilepticus (HP:0002133)2.03883659
82Morphological abnormality of the pyramidal tract (HP:0002062)2.03283145
83Prolonged QT interval (HP:0001657)2.02554342
84Absent/shortened dynein arms (HP:0200106)2.00573111
85Dynein arm defect of respiratory motile cilia (HP:0012255)2.00573111
86Inappropriate behavior (HP:0000719)1.99819541
87Impaired smooth pursuit (HP:0007772)1.98260926
88Clonus (HP:0002169)1.97976591
89Neuronal loss in central nervous system (HP:0002529)1.96124165
90Protruding tongue (HP:0010808)1.96074098
91Pachygyria (HP:0001302)1.93808200
92Craniofacial dystonia (HP:0012179)1.93550836
93Intestinal atresia (HP:0011100)1.91867179
94Hypoplasia of the brainstem (HP:0002365)1.91121643
95Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91121643
96Specific learning disability (HP:0001328)1.90110339
97Oligodactyly (hands) (HP:0001180)1.88523200
98Abnormality of the labia minora (HP:0012880)1.88437122
99Widely spaced teeth (HP:0000687)1.86146698
100Primary atrial arrhythmia (HP:0001692)1.84255915
101Atrial fibrillation (HP:0005110)1.83952334
102Thickened helices (HP:0000391)1.83671313
103Psychosis (HP:0000709)1.83367857
104Cutaneous finger syndactyly (HP:0010554)1.83079471
105Aqueductal stenosis (HP:0002410)1.82976660
106Morphological abnormality of the middle ear (HP:0008609)1.81515773
107Exotropia (HP:0000577)1.81044255
108Lissencephaly (HP:0001339)1.80143718
109Gait ataxia (HP:0002066)1.79466442
110Volvulus (HP:0002580)1.79437695
111Aplasia involving bones of the extremities (HP:0009825)1.78528339
112Aplasia involving bones of the upper limbs (HP:0009823)1.78528339
113Aplasia of the phalanges of the hand (HP:0009802)1.78528339
114Obstructive sleep apnea (HP:0002870)1.76814953
115Impaired vibratory sensation (HP:0002495)1.76272017
116Onion bulb formation (HP:0003383)1.75597419
117Congenital malformation of the right heart (HP:0011723)1.73438212
118Double outlet right ventricle (HP:0001719)1.73438212
119Hemiplegia (HP:0002301)1.73331304
120Failure to thrive in infancy (HP:0001531)1.71113450
121Supraventricular tachycardia (HP:0004755)1.69912016
122Hypoplasia of the corpus callosum (HP:0002079)1.68785665
123Supraventricular arrhythmia (HP:0005115)1.65872565
124Abnormality of the lower motor neuron (HP:0002366)1.64471315
125Abnormal EKG (HP:0003115)1.63019347
126Shawl scrotum (HP:0000049)1.61952929
127Optic nerve hypoplasia (HP:0000609)1.61424268
128Spastic tetraplegia (HP:0002510)1.61416593
129Abnormality of the ischium (HP:0003174)1.60394053
130Genital tract atresia (HP:0001827)1.60383348
131Vaginal atresia (HP:0000148)1.60379993
132Nephronophthisis (HP:0000090)1.58475432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.64044268
2NTRK33.84201384
3EPHA43.55882625
4MAP3K93.13527896
5MAP3K42.84633437
6CASK2.57026305
7MAP2K72.49691991
8MINK12.46781038
9NTRK22.28324768
10PAK62.11639904
11NTRK12.04080161
12DAPK22.01574280
13PNCK1.94104439
14MAPK131.76466458
15TNIK1.72912706
16MAP2K41.72526018
17MAP3K121.68138272
18OXSR11.59560933
19SIK21.56273049
20CDK51.55277226
21CDK191.50364377
22PHKG21.46473523
23PHKG11.46473523
24STK391.45993402
25KSR21.45473936
26UHMK11.41409143
27FRK1.37118624
28PLK21.36189480
29KSR11.33416137
30PRPF4B1.31185558
31PRKD31.28055342
32CAMKK11.26287550
33GRK51.24670012
34CSNK1G21.24653703
35RIPK41.23815071
36PKN11.09854922
37CAMK2A1.09377079
38PRKCG1.08952939
39SGK4941.07930244
40SGK2231.07930244
41DAPK11.04707110
42CAMK2B1.04330832
43MAP3K20.99188030
44LATS20.95326191
45MAPK150.95163413
46PAK30.94796719
47CDK140.93192201
48MARK20.93110037
49CDK180.92552125
50EPHA30.91569590
51DYRK20.91420741
52CDK150.91408588
53FGFR20.91021996
54TYRO30.89259295
55BCR0.88889780
56CAMK1D0.88442305
57STK110.85829764
58CSNK1G30.85248204
59OBSCN0.85045153
60DYRK1A0.83174417
61EPHB20.82819994
62FES0.82790248
63CDK11A0.79775497
64MKNK20.79664116
65CAMK40.79617795
66CAMKK20.78249932
67MAPKAPK50.78076989
68INSRR0.76999621
69STK380.76869400
70RET0.74649859
71WNK10.74152646
72CSNK1A1L0.73750549
73CAMK10.72175636
74CAMK1G0.68667715
75PRKCE0.67839393
76SGK10.66877160
77CAMK2D0.66412902
78BMPR20.65024942
79FGR0.64333431
80NEK60.63575704
81WNK30.61954202
82PRKCH0.61180436
83CDK30.59092499
84SGK20.58558009
85SIK30.57881665
86WNK40.57252767
87CCNB10.56994466
88MAP3K60.56377338
89ARAF0.55952003
90PRKCZ0.54632276
91LIMK10.53832861
92FYN0.53055907
93CAMK2G0.52941308
94CSNK1E0.52422400
95CSNK1G10.50688605
96ROCK20.50575868
97GRK70.49908669
98DMPK0.48770029
99TAOK10.47790454
100PRKAA10.46990273
101CSNK1D0.46670785
102ADRBK20.45309103
103ERBB30.44622903
104MAP3K130.44177362
105SGK30.44024875
106RPS6KA30.44021503
107MAPK120.43650582
108PDPK10.43447213
109ALK0.42569109
110MAPK100.42455581
111PINK10.42329505
112PDK10.40916516
113PTK2B0.40721012
114PRKG10.40533437
115MUSK0.40527108
116PRKACA0.38487126
117RPS6KB10.37413530
118GSK3B0.37331723
119ROCK10.36470218
120PRKDC0.36277059
121AKT30.35178723
122CSNK1A10.34551249
123MAPK80.33701627
124PRKACB0.32808043

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.72635551
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04496864
3GABAergic synapse_Homo sapiens_hsa047272.80623847
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73249315
5Glutamatergic synapse_Homo sapiens_hsa047242.64931309
6Circadian entrainment_Homo sapiens_hsa047132.63704285
7Morphine addiction_Homo sapiens_hsa050322.55115269
8Olfactory transduction_Homo sapiens_hsa047402.50560882
9Long-term potentiation_Homo sapiens_hsa047202.40650934
10Amphetamine addiction_Homo sapiens_hsa050312.30978871
11Dopaminergic synapse_Homo sapiens_hsa047282.19834145
12Salivary secretion_Homo sapiens_hsa049702.08059922
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99007763
14Serotonergic synapse_Homo sapiens_hsa047261.95053082
15Cholinergic synapse_Homo sapiens_hsa047251.93467488
16Insulin secretion_Homo sapiens_hsa049111.93439392
17Cocaine addiction_Homo sapiens_hsa050301.83250633
18Taste transduction_Homo sapiens_hsa047421.83247760
19Long-term depression_Homo sapiens_hsa047301.80674774
20Gastric acid secretion_Homo sapiens_hsa049711.77321046
21Renin secretion_Homo sapiens_hsa049241.73117911
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63132181
23Axon guidance_Homo sapiens_hsa043601.59626205
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54725854
25Oxytocin signaling pathway_Homo sapiens_hsa049211.52859584
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51777408
27Calcium signaling pathway_Homo sapiens_hsa040201.44861554
28Collecting duct acid secretion_Homo sapiens_hsa049661.40220943
29Gap junction_Homo sapiens_hsa045401.35457405
30GnRH signaling pathway_Homo sapiens_hsa049121.30345798
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24223256
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21631864
33cAMP signaling pathway_Homo sapiens_hsa040241.19398293
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18703248
35Type II diabetes mellitus_Homo sapiens_hsa049301.13450715
36ErbB signaling pathway_Homo sapiens_hsa040121.10051807
37Estrogen signaling pathway_Homo sapiens_hsa049151.07869918
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07541309
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06518149
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04246765
41Phototransduction_Homo sapiens_hsa047441.04193051
42Vitamin B6 metabolism_Homo sapiens_hsa007501.01508063
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00715249
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00273113
45Vibrio cholerae infection_Homo sapiens_hsa051100.97181234
46Glioma_Homo sapiens_hsa052140.97072827
47Cardiac muscle contraction_Homo sapiens_hsa042600.96526389
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96373690
49Melanogenesis_Homo sapiens_hsa049160.95663021
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.94694878
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.89504172
52Dorso-ventral axis formation_Homo sapiens_hsa043200.87908099
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86750890
54Pancreatic secretion_Homo sapiens_hsa049720.86338026
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85744646
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.81873220
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80052766
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76448455
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74429557
60Ras signaling pathway_Homo sapiens_hsa040140.73682367
61MAPK signaling pathway_Homo sapiens_hsa040100.73396003
62Choline metabolism in cancer_Homo sapiens_hsa052310.72508388
63Hippo signaling pathway_Homo sapiens_hsa043900.72429380
64Renal cell carcinoma_Homo sapiens_hsa052110.68410108
65Hedgehog signaling pathway_Homo sapiens_hsa043400.67614920
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.67561010
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67312719
68Tight junction_Homo sapiens_hsa045300.66399795
69Oocyte meiosis_Homo sapiens_hsa041140.66348097
70Thyroid hormone synthesis_Homo sapiens_hsa049180.66092222
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65013192
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63815159
73Dilated cardiomyopathy_Homo sapiens_hsa054140.63150652
74Alcoholism_Homo sapiens_hsa050340.59871151
75Alzheimers disease_Homo sapiens_hsa050100.57958324
76Basal cell carcinoma_Homo sapiens_hsa052170.55799821
77Ether lipid metabolism_Homo sapiens_hsa005650.55680591
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54701583
79Parkinsons disease_Homo sapiens_hsa050120.51731063
80Ovarian steroidogenesis_Homo sapiens_hsa049130.51715071
81Rap1 signaling pathway_Homo sapiens_hsa040150.51041281
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50595274
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49911819
84Nitrogen metabolism_Homo sapiens_hsa009100.49644366
85Wnt signaling pathway_Homo sapiens_hsa043100.48719272
86Endocytosis_Homo sapiens_hsa041440.48616327
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.48528431
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48267724
89VEGF signaling pathway_Homo sapiens_hsa043700.47334990
90Protein export_Homo sapiens_hsa030600.47292459
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47211285
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46422115
93AMPK signaling pathway_Homo sapiens_hsa041520.45687382
94Butanoate metabolism_Homo sapiens_hsa006500.45556667
95Prion diseases_Homo sapiens_hsa050200.43218615
96Steroid biosynthesis_Homo sapiens_hsa001000.42968431
97Type I diabetes mellitus_Homo sapiens_hsa049400.42954440
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42192413
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40201016
100Inositol phosphate metabolism_Homo sapiens_hsa005620.39438046
101Endometrial cancer_Homo sapiens_hsa052130.38276641
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35629710
103African trypanosomiasis_Homo sapiens_hsa051430.35453278
104Insulin signaling pathway_Homo sapiens_hsa049100.35288900
105Glucagon signaling pathway_Homo sapiens_hsa049220.35075990
106Oxidative phosphorylation_Homo sapiens_hsa001900.34096607
107Circadian rhythm_Homo sapiens_hsa047100.33372767
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31402877
109mTOR signaling pathway_Homo sapiens_hsa041500.31367936
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31130667
111Bile secretion_Homo sapiens_hsa049760.31059794
112Chemokine signaling pathway_Homo sapiens_hsa040620.30688320
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28403480
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28005626
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27681231

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