

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 4.63781509 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.29472738 |
| 3 | response to interferon-beta (GO:0035456) | 4.23608892 |
| 4 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.17524584 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.91764550 |
| 6 | DNA deamination (GO:0045006) | 3.91292693 |
| 7 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.86507633 |
| 8 | protein maturation by protein folding (GO:0022417) | 3.83754263 |
| 9 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.79820588 |
| 10 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.77368824 |
| 11 | ATP synthesis coupled proton transport (GO:0015986) | 3.77368824 |
| 12 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.73870699 |
| 13 | respiratory electron transport chain (GO:0022904) | 3.72897491 |
| 14 | chaperone-mediated protein transport (GO:0072321) | 3.69669191 |
| 15 | protein complex biogenesis (GO:0070271) | 3.69191982 |
| 16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.68021068 |
| 17 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.67681218 |
| 18 | electron transport chain (GO:0022900) | 3.66822009 |
| 19 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.66020947 |
| 20 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.60070943 |
| 21 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.60070943 |
| 22 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.59419133 |
| 23 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.59419133 |
| 24 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.59419133 |
| 25 | respiratory chain complex IV assembly (GO:0008535) | 3.52012744 |
| 26 | negative regulation of ligase activity (GO:0051352) | 3.50058834 |
| 27 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.50058834 |
| 28 | cytochrome complex assembly (GO:0017004) | 3.47781566 |
| 29 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.43826417 |
| 30 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.40149435 |
| 31 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.40149435 |
| 32 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.30472842 |
| 33 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.30469838 |
| 34 | mannosylation (GO:0097502) | 3.25930295 |
| 35 | GDP-mannose metabolic process (GO:0019673) | 3.16279595 |
| 36 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.15011176 |
| 37 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.13092210 |
| 38 | termination of RNA polymerase III transcription (GO:0006386) | 3.13092210 |
| 39 | platelet dense granule organization (GO:0060155) | 3.12467604 |
| 40 | rRNA modification (GO:0000154) | 3.12434086 |
| 41 | regulation of mitochondrial translation (GO:0070129) | 3.11099970 |
| 42 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.10759817 |
| 43 | NADH dehydrogenase complex assembly (GO:0010257) | 3.10157520 |
| 44 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.10157520 |
| 45 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.10157520 |
| 46 | protein deneddylation (GO:0000338) | 3.06191398 |
| 47 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.04507213 |
| 48 | regulation of cellular amine metabolic process (GO:0033238) | 3.02493420 |
| 49 | positive regulation of ligase activity (GO:0051351) | 2.99998548 |
| 50 | cellular response to interferon-beta (GO:0035458) | 2.98906796 |
| 51 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.97904345 |
| 52 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.97904345 |
| 53 | cullin deneddylation (GO:0010388) | 2.89217014 |
| 54 | C-terminal protein lipidation (GO:0006501) | 2.86613639 |
| 55 | xenobiotic catabolic process (GO:0042178) | 2.86092510 |
| 56 | peptidyl-histidine modification (GO:0018202) | 2.82440623 |
| 57 | protein targeting to mitochondrion (GO:0006626) | 2.82219736 |
| 58 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.80732212 |
| 59 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.75919512 |
| 60 | positive regulation of cell cycle arrest (GO:0071158) | 2.75478992 |
| 61 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.73127901 |
| 62 | GPI anchor biosynthetic process (GO:0006506) | 2.70537112 |
| 63 | hydrogen ion transmembrane transport (GO:1902600) | 2.67186904 |
| 64 | cytidine deamination (GO:0009972) | 2.65477896 |
| 65 | cytidine metabolic process (GO:0046087) | 2.65477896 |
| 66 | cytidine catabolic process (GO:0006216) | 2.65477896 |
| 67 | cellular response to zinc ion (GO:0071294) | 2.65001133 |
| 68 | pseudouridine synthesis (GO:0001522) | 2.64784286 |
| 69 | branched-chain amino acid catabolic process (GO:0009083) | 2.62755928 |
| 70 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.61560881 |
| 71 | purine nucleotide salvage (GO:0032261) | 2.60301324 |
| 72 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.59060444 |
| 73 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.56605735 |
| 74 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.54993285 |
| 75 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.54579299 |
| 76 | metallo-sulfur cluster assembly (GO:0031163) | 2.54365211 |
| 77 | iron-sulfur cluster assembly (GO:0016226) | 2.54365211 |
| 78 | establishment of protein localization to mitochondrion (GO:0072655) | 2.54332988 |
| 79 | proton transport (GO:0015992) | 2.53202972 |
| 80 | negative regulation of protein ubiquitination (GO:0031397) | 2.52381194 |
| 81 | regulation of ligase activity (GO:0051340) | 2.48447091 |
| 82 | hydrogen transport (GO:0006818) | 2.48065840 |
| 83 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.47076958 |
| 84 | protein localization to mitochondrion (GO:0070585) | 2.46482162 |
| 85 | establishment of viral latency (GO:0019043) | 2.44039984 |
| 86 | autophagic vacuole fusion (GO:0000046) | 2.44012960 |
| 87 | glutathione derivative biosynthetic process (GO:1901687) | 2.42432620 |
| 88 | glutathione derivative metabolic process (GO:1901685) | 2.42432620 |
| 89 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.41882089 |
| 90 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.41882089 |
| 91 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.41571151 |
| 92 | base-excision repair, AP site formation (GO:0006285) | 2.40718687 |
| 93 | protein-cofactor linkage (GO:0018065) | 2.40663441 |
| 94 | positive regulation of defense response to virus by host (GO:0002230) | 2.39789745 |
| 95 | rRNA methylation (GO:0031167) | 2.39708126 |
| 96 | deoxyribonucleotide catabolic process (GO:0009264) | 2.39463705 |
| 97 | nucleoside salvage (GO:0043174) | 2.39107450 |
| 98 | GMP metabolic process (GO:0046037) | 2.37521213 |
| 99 | positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357 | 2.37189759 |
| 100 | deoxyribose phosphate catabolic process (GO:0046386) | 2.37181297 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.46516212 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.09682406 |
| 3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.70707482 |
| 4 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.62759574 |
| 5 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.58001532 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.37042802 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.06248710 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.88836396 |
| 9 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.86048862 |
| 10 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.79933127 |
| 11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.71074995 |
| 12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.55939810 |
| 13 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.51243221 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.44507391 |
| 15 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.43634908 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.35093816 |
| 17 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.34389816 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.33901205 |
| 19 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.29603976 |
| 20 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.28870898 |
| 21 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.21901944 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.19467728 |
| 23 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.14831082 |
| 24 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.13320537 |
| 25 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.07090018 |
| 26 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.06929554 |
| 27 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.03062157 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.95865260 |
| 29 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.95501029 |
| 30 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.88070213 |
| 31 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.88057676 |
| 32 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.87976631 |
| 33 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.84984146 |
| 34 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.81206997 |
| 35 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.71627757 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.62069123 |
| 37 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.59072264 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.58500210 |
| 39 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.58343266 |
| 40 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.52234774 |
| 41 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.51424843 |
| 42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.46432310 |
| 43 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.46361534 |
| 44 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.44639714 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.43870579 |
| 46 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.43312200 |
| 47 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.42164885 |
| 48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.37496342 |
| 49 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.36260844 |
| 50 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.35636233 |
| 51 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.35019145 |
| 52 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34177874 |
| 53 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.30875631 |
| 54 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29882514 |
| 55 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.29740033 |
| 56 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.29431755 |
| 57 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28812319 |
| 58 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.28050864 |
| 59 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.25395805 |
| 60 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.23772764 |
| 61 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21667963 |
| 62 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.19900774 |
| 63 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.18697529 |
| 64 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.16832373 |
| 65 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.15338244 |
| 66 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.11757180 |
| 67 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.11551054 |
| 68 | MYB_26560356_Chip-Seq_TH2_Human | 1.10392404 |
| 69 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.07502356 |
| 70 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.06322772 |
| 71 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.03610819 |
| 72 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.03552359 |
| 73 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.03345123 |
| 74 | GATA3_26560356_Chip-Seq_TH2_Human | 1.01563494 |
| 75 | * LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.00895310 |
| 76 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99307393 |
| 77 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.98723661 |
| 78 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.96350285 |
| 79 | AR_20517297_ChIP-Seq_VCAP_Human | 0.95572633 |
| 80 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.94848097 |
| 81 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.94804847 |
| 82 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.92558417 |
| 83 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.92014684 |
| 84 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.91680275 |
| 85 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.90797219 |
| 86 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.90704380 |
| 87 | * STAT1_20625510_ChIP-Seq_HELA_Human | 0.90354174 |
| 88 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.90287260 |
| 89 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.88434602 |
| 90 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.87284218 |
| 91 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.86012284 |
| 92 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.85443484 |
| 93 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.84333387 |
| 94 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.82907922 |
| 95 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.82019050 |
| 96 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.81754816 |
| 97 | * P300_27268052_Chip-Seq_Bcells_Human | 0.81019976 |
| 98 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.80728526 |
| 99 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.80676476 |
| 100 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.78756639 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 3.72337259 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.00752158 |
| 3 | MP0003186_abnormal_redox_activity | 2.84323377 |
| 4 | MP0005671_abnormal_response_to | 2.82179236 |
| 5 | MP0009785_altered_susceptibility_to | 2.68847228 |
| 6 | MP0003195_calcinosis | 2.50117321 |
| 7 | MP0002148_abnormal_hypersensitivity_rea | 2.49915161 |
| 8 | MP0005058_abnormal_lysosome_morphology | 2.29218062 |
| 9 | MP0003724_increased_susceptibility_to | 2.15096594 |
| 10 | MP0000372_irregular_coat_pigmentation | 2.11187256 |
| 11 | MP0009333_abnormal_splenocyte_physiolog | 2.11015051 |
| 12 | MP0005000_abnormal_immune_tolerance | 1.98699814 |
| 13 | MP0006036_abnormal_mitochondrial_physio | 1.97170372 |
| 14 | MP0003436_decreased_susceptibility_to | 1.96459489 |
| 15 | MP0001853_heart_inflammation | 1.94073710 |
| 16 | MP0003191_abnormal_cellular_cholesterol | 1.94058536 |
| 17 | MP0001764_abnormal_homeostasis | 1.91089623 |
| 18 | MP0006082_CNS_inflammation | 1.84491787 |
| 19 | MP0005025_abnormal_response_to | 1.82201986 |
| 20 | MP0005075_abnormal_melanosome_morpholog | 1.80168570 |
| 21 | MP0009840_abnormal_foam_cell | 1.76629120 |
| 22 | MP0003786_premature_aging | 1.75003022 |
| 23 | MP0008875_abnormal_xenobiotic_pharmacok | 1.70756704 |
| 24 | MP0002419_abnormal_innate_immunity | 1.65698686 |
| 25 | MP0000685_abnormal_immune_system | 1.64783703 |
| 26 | MP0002723_abnormal_immune_serum | 1.63233296 |
| 27 | MP0003011_delayed_dark_adaptation | 1.60583117 |
| 28 | MP0005084_abnormal_gallbladder_morpholo | 1.59548470 |
| 29 | MP0002452_abnormal_antigen_presenting | 1.58709012 |
| 30 | MP0005464_abnormal_platelet_physiology | 1.58378244 |
| 31 | MP0002132_abnormal_respiratory_system | 1.56439433 |
| 32 | MP0005365_abnormal_bile_salt | 1.54310034 |
| 33 | MP0001845_abnormal_inflammatory_respons | 1.53396322 |
| 34 | MP0001790_abnormal_immune_system | 1.51762307 |
| 35 | MP0005387_immune_system_phenotype | 1.51762307 |
| 36 | MP0001819_abnormal_immune_cell | 1.50015854 |
| 37 | MP0002420_abnormal_adaptive_immunity | 1.49043619 |
| 38 | MP0008469_abnormal_protein_level | 1.48188637 |
| 39 | MP0001800_abnormal_humoral_immune | 1.47102694 |
| 40 | MP0003763_abnormal_thymus_physiology | 1.47088960 |
| 41 | MP0002277_abnormal_respiratory_mucosa | 1.46451262 |
| 42 | MP0002139_abnormal_hepatobiliary_system | 1.44480561 |
| 43 | MP0003075_altered_response_to | 1.44091604 |
| 44 | MP0001533_abnormal_skeleton_physiology | 1.41090976 |
| 45 | MP0001542_abnormal_bone_strength | 1.36954845 |
| 46 | MP0009764_decreased_sensitivity_to | 1.32733301 |
| 47 | MP0000516_abnormal_urinary_system | 1.31692400 |
| 48 | MP0005367_renal/urinary_system_phenotyp | 1.31692400 |
| 49 | MP0002163_abnormal_gland_morphology | 1.30613780 |
| 50 | MP0006054_spinal_hemorrhage | 1.30246226 |
| 51 | MP0005332_abnormal_amino_acid | 1.28663130 |
| 52 | MP0005165_increased_susceptibility_to | 1.28270137 |
| 53 | MP0002837_dystrophic_cardiac_calcinosis | 1.26757970 |
| 54 | MP0005360_urolithiasis | 1.25956131 |
| 55 | MP0002166_altered_tumor_susceptibility | 1.24778750 |
| 56 | MP0001545_abnormal_hematopoietic_system | 1.24016309 |
| 57 | MP0005397_hematopoietic_system_phenotyp | 1.24016309 |
| 58 | MP0002405_respiratory_system_inflammati | 1.23775111 |
| 59 | MP0010386_abnormal_urinary_bladder | 1.23747181 |
| 60 | MP0003866_abnormal_defecation | 1.22990759 |
| 61 | MP0008058_abnormal_DNA_repair | 1.22052989 |
| 62 | MP0005636_abnormal_mineral_homeostasis | 1.21098912 |
| 63 | MP0003718_maternal_effect | 1.18677732 |
| 64 | MP0010155_abnormal_intestine_physiology | 1.18292934 |
| 65 | MP0002006_tumorigenesis | 1.18230602 |
| 66 | MP0001873_stomach_inflammation | 1.18185355 |
| 67 | MP0005085_abnormal_gallbladder_physiolo | 1.17820182 |
| 68 | MP0000689_abnormal_spleen_morphology | 1.15205653 |
| 69 | MP0005379_endocrine/exocrine_gland_phen | 1.11978826 |
| 70 | MP0006072_abnormal_retinal_apoptosis | 1.10256582 |
| 71 | MP0000343_altered_response_to | 1.10195920 |
| 72 | MP0008872_abnormal_physiological_respon | 1.10098001 |
| 73 | MP0000465_gastrointestinal_hemorrhage | 1.09001382 |
| 74 | MP0009643_abnormal_urine_homeostasis | 1.07508299 |
| 75 | MP0000716_abnormal_immune_system | 1.07222029 |
| 76 | MP0005408_hypopigmentation | 1.06208026 |
| 77 | MP0002876_abnormal_thyroid_physiology | 1.04740395 |
| 78 | MP0006035_abnormal_mitochondrial_morpho | 1.03552910 |
| 79 | MP0009763_increased_sensitivity_to | 1.01415750 |
| 80 | MP0004019_abnormal_vitamin_homeostasis | 1.01279354 |
| 81 | MP0005319_abnormal_enzyme/_coenzyme | 0.98183968 |
| 82 | MP0002722_abnormal_immune_system | 0.97735893 |
| 83 | MP0000358_abnormal_cell_content/ | 0.97664701 |
| 84 | MP0005310_abnormal_salivary_gland | 0.96711685 |
| 85 | MP0002429_abnormal_blood_cell | 0.96443816 |
| 86 | MP0002398_abnormal_bone_marrow | 0.95509833 |
| 87 | MP0001756_abnormal_urination | 0.93749037 |
| 88 | MP0009697_abnormal_copulation | 0.92896396 |
| 89 | MP0002254_reproductive_system_inflammat | 0.92809227 |
| 90 | MP0002693_abnormal_pancreas_physiology | 0.91164226 |
| 91 | MP0005410_abnormal_fertilization | 0.89724924 |
| 92 | MP0000858_altered_metastatic_potential | 0.89354364 |
| 93 | MP0005645_abnormal_hypothalamus_physiol | 0.86866406 |
| 94 | MP0001919_abnormal_reproductive_system | 0.86775021 |
| 95 | MP0005166_decreased_susceptibility_to | 0.86072920 |
| 96 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.86046693 |
| 97 | MP0004147_increased_porphyrin_level | 0.85994836 |
| 98 | MP0010329_abnormal_lipoprotein_level | 0.85766467 |
| 99 | MP0009278_abnormal_bone_marrow | 0.81987155 |
| 100 | MP0005083_abnormal_biliary_tract | 0.79506403 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Mitochondrial inheritance (HP:0001427) | 4.51033139 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.37479460 |
| 3 | Hepatocellular necrosis (HP:0001404) | 4.35162542 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.14905016 |
| 5 | Hepatic necrosis (HP:0002605) | 4.01217691 |
| 6 | Acute encephalopathy (HP:0006846) | 3.99500710 |
| 7 | Increased CSF lactate (HP:0002490) | 3.99052048 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.72225960 |
| 9 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.64769083 |
| 10 | Type I transferrin isoform profile (HP:0003642) | 3.62706483 |
| 11 | Renal Fanconi syndrome (HP:0001994) | 3.41262698 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.39871831 |
| 13 | Lipid accumulation in hepatocytes (HP:0006561) | 3.29712827 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 3.16408616 |
| 15 | Stomatitis (HP:0010280) | 3.16191532 |
| 16 | Vacuolated lymphocytes (HP:0001922) | 3.14565550 |
| 17 | Abnormal protein glycosylation (HP:0012346) | 3.14369059 |
| 18 | Abnormal glycosylation (HP:0012345) | 3.14369059 |
| 19 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.14369059 |
| 20 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.14369059 |
| 21 | Petechiae (HP:0000967) | 3.00875116 |
| 22 | Cerebral edema (HP:0002181) | 2.98585563 |
| 23 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.93571715 |
| 24 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.93571715 |
| 25 | Abnormality of glycolipid metabolism (HP:0010969) | 2.93571715 |
| 26 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.93531604 |
| 27 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.93531604 |
| 28 | Increased intramyocellular lipid droplets (HP:0012240) | 2.87519195 |
| 29 | Lactic acidosis (HP:0003128) | 2.84708737 |
| 30 | Respiratory failure (HP:0002878) | 2.81422422 |
| 31 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.79061717 |
| 32 | Increased serum lactate (HP:0002151) | 2.72205478 |
| 33 | Aplastic anemia (HP:0001915) | 2.72127959 |
| 34 | Increased muscle lipid content (HP:0009058) | 2.67293980 |
| 35 | Exertional dyspnea (HP:0002875) | 2.66705839 |
| 36 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.60140223 |
| 37 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.59831257 |
| 38 | Methylmalonic aciduria (HP:0012120) | 2.53783871 |
| 39 | Reduced antithrombin III activity (HP:0001976) | 2.48872513 |
| 40 | Dicarboxylic aciduria (HP:0003215) | 2.43910008 |
| 41 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.43910008 |
| 42 | Exercise intolerance (HP:0003546) | 2.40890822 |
| 43 | Lethargy (HP:0001254) | 2.40667257 |
| 44 | Methylmalonic acidemia (HP:0002912) | 2.35305293 |
| 45 | Hepatosplenomegaly (HP:0001433) | 2.33038173 |
| 46 | CNS demyelination (HP:0007305) | 2.32279572 |
| 47 | Myositis (HP:0100614) | 2.31203362 |
| 48 | Prolonged neonatal jaundice (HP:0006579) | 2.27536002 |
| 49 | Respiratory difficulties (HP:0002880) | 2.15819909 |
| 50 | Testicular atrophy (HP:0000029) | 2.15080132 |
| 51 | IgG deficiency (HP:0004315) | 2.10054126 |
| 52 | Pancytopenia (HP:0001876) | 2.08397271 |
| 53 | Abnormality of macrophages (HP:0004311) | 2.03098683 |
| 54 | Abnormality of urine glucose concentration (HP:0011016) | 2.02958045 |
| 55 | Glycosuria (HP:0003076) | 2.02958045 |
| 56 | Optic disc pallor (HP:0000543) | 2.02534247 |
| 57 | Systemic lupus erythematosus (HP:0002725) | 2.02066717 |
| 58 | Abnormal pupillary function (HP:0007686) | 2.01648919 |
| 59 | Progressive neurologic deterioration (HP:0002344) | 1.99984986 |
| 60 | Orchitis (HP:0100796) | 1.99729324 |
| 61 | Microvesicular hepatic steatosis (HP:0001414) | 1.98299829 |
| 62 | Abnormality of the anterior horn cell (HP:0006802) | 1.97732534 |
| 63 | Degeneration of anterior horn cells (HP:0002398) | 1.97732534 |
| 64 | Abnormality of methionine metabolism (HP:0010901) | 1.93256440 |
| 65 | Abnormality of renal resorption (HP:0011038) | 1.92538015 |
| 66 | Dysostosis multiplex (HP:0000943) | 1.91571307 |
| 67 | Loss of speech (HP:0002371) | 1.91505497 |
| 68 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.91189809 |
| 69 | Ketoacidosis (HP:0001993) | 1.90189432 |
| 70 | Hypokinesia (HP:0002375) | 1.89277581 |
| 71 | Neutropenia (HP:0001875) | 1.86118068 |
| 72 | Retrobulbar optic neuritis (HP:0100654) | 1.85282329 |
| 73 | Optic neuritis (HP:0100653) | 1.85282329 |
| 74 | Emotional lability (HP:0000712) | 1.84911964 |
| 75 | Opisthotonus (HP:0002179) | 1.83372551 |
| 76 | Pustule (HP:0200039) | 1.83120383 |
| 77 | Severe combined immunodeficiency (HP:0004430) | 1.81743531 |
| 78 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.81564822 |
| 79 | Abnormality of T cells (HP:0002843) | 1.80756263 |
| 80 | Abnormality of T cell physiology (HP:0011840) | 1.79287993 |
| 81 | Recurrent cutaneous fungal infections (HP:0011370) | 1.78700266 |
| 82 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.78700266 |
| 83 | Generalized aminoaciduria (HP:0002909) | 1.77734550 |
| 84 | Rough bone trabeculation (HP:0100670) | 1.77680535 |
| 85 | Nausea (HP:0002018) | 1.76263169 |
| 86 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.76232451 |
| 87 | Recurrent fungal infections (HP:0002841) | 1.75556806 |
| 88 | Anorexia (HP:0002039) | 1.75148983 |
| 89 | Progressive microcephaly (HP:0000253) | 1.74809124 |
| 90 | Hypoproteinemia (HP:0003075) | 1.74627634 |
| 91 | Hyperphosphaturia (HP:0003109) | 1.74446758 |
| 92 | Pancreatitis (HP:0001733) | 1.74249654 |
| 93 | Increased serum pyruvate (HP:0003542) | 1.73842768 |
| 94 | Microretrognathia (HP:0000308) | 1.73381931 |
| 95 | Sparse eyelashes (HP:0000653) | 1.71081694 |
| 96 | Tongue fasciculations (HP:0001308) | 1.69795507 |
| 97 | Purpura (HP:0000979) | 1.69458208 |
| 98 | Abnormality of vitamin B metabolism (HP:0004340) | 1.69298063 |
| 99 | Beaking of vertebral bodies (HP:0004568) | 1.67656100 |
| 100 | Abnormal spermatogenesis (HP:0008669) | 1.67380433 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.65821838 |
| 2 | MST4 | 3.58455338 |
| 3 | TESK1 | 3.38485943 |
| 4 | TESK2 | 3.33284279 |
| 5 | NME2 | 3.08445072 |
| 6 | BCKDK | 2.95905315 |
| 7 | STK16 | 2.52605690 |
| 8 | TXK | 2.46430978 |
| 9 | MAP3K12 | 2.35693780 |
| 10 | LIMK1 | 2.18588243 |
| 11 | PIM2 | 2.10427510 |
| 12 | KDR | 2.01917551 |
| 13 | BUB1 | 1.72796401 |
| 14 | NUAK1 | 1.71694580 |
| 15 | MAP4K2 | 1.65948532 |
| 16 | PBK | 1.65416438 |
| 17 | EIF2AK3 | 1.62637389 |
| 18 | EIF2AK1 | 1.61194978 |
| 19 | VRK1 | 1.57752282 |
| 20 | ERN1 | 1.48462194 |
| 21 | TRIM28 | 1.42094620 |
| 22 | PDK2 | 1.39227950 |
| 23 | IKBKB | 1.38339748 |
| 24 | TBK1 | 1.35922641 |
| 25 | EPHA3 | 1.31614173 |
| 26 | MAP4K1 | 1.29249421 |
| 27 | ARAF | 1.26568942 |
| 28 | MAP3K3 | 1.26075619 |
| 29 | ZAK | 1.25558638 |
| 30 | MYLK | 1.23957099 |
| 31 | FRK | 1.20193987 |
| 32 | MAP3K11 | 1.19964678 |
| 33 | NME1 | 1.17918987 |
| 34 | TYK2 | 1.14982320 |
| 35 | GRK1 | 1.13269941 |
| 36 | ADRBK2 | 1.08965626 |
| 37 | EPHA2 | 1.08723738 |
| 38 | FER | 1.08604428 |
| 39 | ABL2 | 1.07501596 |
| 40 | DAPK1 | 1.06547317 |
| 41 | TAOK3 | 1.05788530 |
| 42 | SRPK1 | 1.02196709 |
| 43 | IKBKE | 0.96610356 |
| 44 | SCYL2 | 0.95368694 |
| 45 | TNK2 | 0.93254033 |
| 46 | GRK7 | 0.92897667 |
| 47 | GRK6 | 0.91204461 |
| 48 | EPHB1 | 0.90964723 |
| 49 | SIK3 | 0.84087884 |
| 50 | PAK4 | 0.83610793 |
| 51 | MUSK | 0.83265214 |
| 52 | ILK | 0.80365873 |
| 53 | TAOK2 | 0.78439982 |
| 54 | LMTK2 | 0.76451793 |
| 55 | MAPKAPK3 | 0.72139001 |
| 56 | TLK1 | 0.71105073 |
| 57 | TGFBR2 | 0.69853537 |
| 58 | NLK | 0.69180931 |
| 59 | NEK1 | 0.68977307 |
| 60 | KIT | 0.68627305 |
| 61 | IRAK3 | 0.68279659 |
| 62 | TEC | 0.67922657 |
| 63 | STK10 | 0.67353711 |
| 64 | FES | 0.66556924 |
| 65 | CSNK1G3 | 0.64400039 |
| 66 | JAK3 | 0.57538285 |
| 67 | RPS6KA5 | 0.57470974 |
| 68 | PLK3 | 0.57131023 |
| 69 | EIF2AK2 | 0.56192023 |
| 70 | ZAP70 | 0.55974998 |
| 71 | CDK19 | 0.55063778 |
| 72 | PRKCI | 0.54061507 |
| 73 | CSNK1G1 | 0.51262641 |
| 74 | DAPK3 | 0.50529964 |
| 75 | IRAK4 | 0.49900501 |
| 76 | ITK | 0.49195648 |
| 77 | LYN | 0.48513150 |
| 78 | PTK2B | 0.46634134 |
| 79 | MAPKAPK2 | 0.46310852 |
| 80 | BMPR1B | 0.45723765 |
| 81 | INSRR | 0.45720302 |
| 82 | FLT3 | 0.43041989 |
| 83 | CSF1R | 0.42639082 |
| 84 | STK4 | 0.42615471 |
| 85 | PAK1 | 0.40630905 |
| 86 | GRK5 | 0.39863653 |
| 87 | LRRK2 | 0.37064152 |
| 88 | BTK | 0.36709986 |
| 89 | CSK | 0.36588917 |
| 90 | LCK | 0.35866137 |
| 91 | CSNK2A1 | 0.34896426 |
| 92 | HIPK2 | 0.34590341 |
| 93 | ERBB3 | 0.34164553 |
| 94 | TIE1 | 0.33754917 |
| 95 | PRKCQ | 0.33294289 |
| 96 | CSNK2A2 | 0.32847616 |
| 97 | CSNK1A1L | 0.32539694 |
| 98 | MARK3 | 0.31635520 |
| 99 | OXSR1 | 0.31510426 |
| 100 | BMPR2 | 0.30951125 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.94277244 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.66815296 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 2.88908908 |
| 4 | Protein export_Homo sapiens_hsa03060 | 2.77709619 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.23479389 |
| 6 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.20549554 |
| 7 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.19924859 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 1.95014283 |
| 9 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.93050197 |
| 10 | Huntingtons disease_Homo sapiens_hsa05016 | 1.91058105 |
| 11 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.86972631 |
| 12 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.82856671 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 1.82595764 |
| 14 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.75964546 |
| 15 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.57942676 |
| 16 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.52606042 |
| 17 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.51768603 |
| 18 | Homologous recombination_Homo sapiens_hsa03440 | 1.46007514 |
| 19 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.45540203 |
| 20 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.44874436 |
| 21 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.43408183 |
| 22 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.42586015 |
| 23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.41657158 |
| 24 | Allograft rejection_Homo sapiens_hsa05330 | 1.40727704 |
| 25 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.38626192 |
| 26 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.33797442 |
| 27 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.31551060 |
| 28 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.31271399 |
| 29 | Peroxisome_Homo sapiens_hsa04146 | 1.29779536 |
| 30 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.21927449 |
| 31 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.21845006 |
| 32 | Base excision repair_Homo sapiens_hsa03410 | 1.21029740 |
| 33 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.20775795 |
| 34 | Mismatch repair_Homo sapiens_hsa03430 | 1.18679814 |
| 35 | DNA replication_Homo sapiens_hsa03030 | 1.08861864 |
| 36 | Asthma_Homo sapiens_hsa05310 | 1.08388802 |
| 37 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.08321403 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.07575496 |
| 39 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.06860849 |
| 40 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.06568530 |
| 41 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.05625818 |
| 42 | Other glycan degradation_Homo sapiens_hsa00511 | 1.05202632 |
| 43 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.03830200 |
| 44 | Lysosome_Homo sapiens_hsa04142 | 1.01930940 |
| 45 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.00908457 |
| 46 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.96175968 |
| 47 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.95187843 |
| 48 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.94636016 |
| 49 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.94199209 |
| 50 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.93567046 |
| 51 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.92437528 |
| 52 | Purine metabolism_Homo sapiens_hsa00230 | 0.87537918 |
| 53 | Sulfur relay system_Homo sapiens_hsa04122 | 0.86916582 |
| 54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.86504549 |
| 55 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.85218279 |
| 56 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.85060215 |
| 57 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.84992917 |
| 58 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.84179398 |
| 59 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.81710635 |
| 60 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.79645348 |
| 61 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.79129322 |
| 62 | Galactose metabolism_Homo sapiens_hsa00052 | 0.75795044 |
| 63 | Legionellosis_Homo sapiens_hsa05134 | 0.74722753 |
| 64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.73049004 |
| 65 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.72977157 |
| 66 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.72942299 |
| 67 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.71061871 |
| 68 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.70247534 |
| 69 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.69782354 |
| 70 | RNA degradation_Homo sapiens_hsa03018 | 0.69575919 |
| 71 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.68212573 |
| 72 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.68207705 |
| 73 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.66149809 |
| 74 | Carbon metabolism_Homo sapiens_hsa01200 | 0.65529026 |
| 75 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.64930042 |
| 76 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.62793882 |
| 77 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.61456649 |
| 78 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.60970948 |
| 79 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.59708422 |
| 80 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.57649026 |
| 81 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.55989074 |
| 82 | Mineral absorption_Homo sapiens_hsa04978 | 0.53650798 |
| 83 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.53357459 |
| 84 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.51283783 |
| 85 | Basal transcription factors_Homo sapiens_hsa03022 | 0.50561703 |
| 86 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.49272721 |
| 87 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.48478238 |
| 88 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.48429015 |
| 89 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.48210626 |
| 90 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.46803587 |
| 91 | Retinol metabolism_Homo sapiens_hsa00830 | 0.46612364 |
| 92 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.46236961 |
| 93 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.45888561 |
| 94 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.45391319 |
| 95 | Pertussis_Homo sapiens_hsa05133 | 0.44889932 |
| 96 | Spliceosome_Homo sapiens_hsa03040 | 0.44503357 |
| 97 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.43871612 |
| 98 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.42535780 |
| 99 | Malaria_Homo sapiens_hsa05144 | 0.42379450 |
| 100 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.39716661 |

