TMEM179B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.63781509
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.29472738
3response to interferon-beta (GO:0035456)4.23608892
4regulation of cellular amino acid metabolic process (GO:0006521)4.17524584
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91764550
6DNA deamination (GO:0045006)3.91292693
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.86507633
8protein maturation by protein folding (GO:0022417)3.83754263
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.79820588
10energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77368824
11ATP synthesis coupled proton transport (GO:0015986)3.77368824
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.73870699
13respiratory electron transport chain (GO:0022904)3.72897491
14chaperone-mediated protein transport (GO:0072321)3.69669191
15protein complex biogenesis (GO:0070271)3.69191982
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.68021068
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67681218
18electron transport chain (GO:0022900)3.66822009
19antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.66020947
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60070943
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60070943
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59419133
23signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59419133
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59419133
25respiratory chain complex IV assembly (GO:0008535)3.52012744
26negative regulation of ligase activity (GO:0051352)3.50058834
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.50058834
28cytochrome complex assembly (GO:0017004)3.47781566
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43826417
30signal transduction involved in DNA damage checkpoint (GO:0072422)3.40149435
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.40149435
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.30472842
33mitochondrial respiratory chain complex assembly (GO:0033108)3.30469838
34mannosylation (GO:0097502)3.25930295
35GDP-mannose metabolic process (GO:0019673)3.16279595
36antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.15011176
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.13092210
38termination of RNA polymerase III transcription (GO:0006386)3.13092210
39platelet dense granule organization (GO:0060155)3.12467604
40rRNA modification (GO:0000154)3.12434086
41regulation of mitochondrial translation (GO:0070129)3.11099970
42positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10759817
43NADH dehydrogenase complex assembly (GO:0010257)3.10157520
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10157520
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.10157520
46protein deneddylation (GO:0000338)3.06191398
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04507213
48regulation of cellular amine metabolic process (GO:0033238)3.02493420
49positive regulation of ligase activity (GO:0051351)2.99998548
50cellular response to interferon-beta (GO:0035458)2.98906796
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97904345
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97904345
53cullin deneddylation (GO:0010388)2.89217014
54C-terminal protein lipidation (GO:0006501)2.86613639
55xenobiotic catabolic process (GO:0042178)2.86092510
56peptidyl-histidine modification (GO:0018202)2.82440623
57protein targeting to mitochondrion (GO:0006626)2.82219736
58negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80732212
59DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.75919512
60positive regulation of cell cycle arrest (GO:0071158)2.75478992
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73127901
62GPI anchor biosynthetic process (GO:0006506)2.70537112
63hydrogen ion transmembrane transport (GO:1902600)2.67186904
64cytidine deamination (GO:0009972)2.65477896
65cytidine metabolic process (GO:0046087)2.65477896
66cytidine catabolic process (GO:0006216)2.65477896
67cellular response to zinc ion (GO:0071294)2.65001133
68pseudouridine synthesis (GO:0001522)2.64784286
69branched-chain amino acid catabolic process (GO:0009083)2.62755928
70positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61560881
71purine nucleotide salvage (GO:0032261)2.60301324
72preassembly of GPI anchor in ER membrane (GO:0016254)2.59060444
73purine deoxyribonucleotide catabolic process (GO:0009155)2.56605735
74regulation of ubiquitin-protein transferase activity (GO:0051438)2.54993285
75dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.54579299
76metallo-sulfur cluster assembly (GO:0031163)2.54365211
77iron-sulfur cluster assembly (GO:0016226)2.54365211
78establishment of protein localization to mitochondrion (GO:0072655)2.54332988
79proton transport (GO:0015992)2.53202972
80negative regulation of protein ubiquitination (GO:0031397)2.52381194
81regulation of ligase activity (GO:0051340)2.48447091
82hydrogen transport (GO:0006818)2.48065840
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47076958
84protein localization to mitochondrion (GO:0070585)2.46482162
85establishment of viral latency (GO:0019043)2.44039984
86autophagic vacuole fusion (GO:0000046)2.44012960
87glutathione derivative biosynthetic process (GO:1901687)2.42432620
88glutathione derivative metabolic process (GO:1901685)2.42432620
89energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.41882089
90ATP hydrolysis coupled proton transport (GO:0015991)2.41882089
91negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.41571151
92base-excision repair, AP site formation (GO:0006285)2.40718687
93protein-cofactor linkage (GO:0018065)2.40663441
94positive regulation of defense response to virus by host (GO:0002230)2.39789745
95rRNA methylation (GO:0031167)2.39708126
96deoxyribonucleotide catabolic process (GO:0009264)2.39463705
97nucleoside salvage (GO:0043174)2.39107450
98GMP metabolic process (GO:0046037)2.37521213
99positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.37189759
100deoxyribose phosphate catabolic process (GO:0046386)2.37181297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.46516212
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.09682406
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.70707482
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62759574
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.58001532
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.37042802
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.06248710
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.88836396
9SRF_21415370_ChIP-Seq_HL-1_Mouse2.86048862
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.79933127
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71074995
12VDR_23849224_ChIP-Seq_CD4+_Human2.55939810
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51243221
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44507391
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.43634908
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35093816
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34389816
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33901205
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29603976
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28870898
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.21901944
22FOXP3_21729870_ChIP-Seq_TREG_Human2.19467728
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.14831082
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.13320537
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.07090018
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06929554
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03062157
28DCP1A_22483619_ChIP-Seq_HELA_Human1.95865260
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95501029
30ELK1_19687146_ChIP-ChIP_HELA_Human1.88070213
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88057676
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87976631
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.84984146
34GABP_19822575_ChIP-Seq_HepG2_Human1.81206997
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71627757
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62069123
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59072264
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58500210
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58343266
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52234774
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51424843
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.46432310
43SPI1_23547873_ChIP-Seq_NB4_Human1.46361534
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44639714
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43870579
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43312200
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42164885
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37496342
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36260844
50TFEB_21752829_ChIP-Seq_HELA_Human1.35636233
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35019145
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34177874
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.30875631
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29882514
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29740033
56* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29431755
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28812319
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28050864
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.25395805
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23772764
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21667963
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19900774
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18697529
64TTF2_22483619_ChIP-Seq_HELA_Human1.16832373
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15338244
66XRN2_22483619_ChIP-Seq_HELA_Human1.11757180
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11551054
68MYB_26560356_Chip-Seq_TH2_Human1.10392404
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07502356
70* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06322772
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03610819
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03552359
73* KDM5A_27292631_Chip-Seq_BREAST_Human1.03345123
74GATA3_26560356_Chip-Seq_TH2_Human1.01563494
75* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00895310
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99307393
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98723661
78MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96350285
79AR_20517297_ChIP-Seq_VCAP_Human0.95572633
80BCL6_27268052_Chip-Seq_Bcells_Human0.94848097
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94804847
82* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92558417
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.92014684
84CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91680275
85ELF5_23300383_ChIP-Seq_T47D_Human0.90797219
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90704380
87* STAT1_20625510_ChIP-Seq_HELA_Human0.90354174
88CIITA_25753668_ChIP-Seq_RAJI_Human0.90287260
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88434602
90ERG_20517297_ChIP-Seq_VCAP_Human0.87284218
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.86012284
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85443484
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84333387
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82907922
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82019050
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81754816
97* P300_27268052_Chip-Seq_Bcells_Human0.81019976
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80728526
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.80676476
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78756639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.72337259
2MP0001835_abnormal_antigen_presentation3.00752158
3MP0003186_abnormal_redox_activity2.84323377
4MP0005671_abnormal_response_to2.82179236
5MP0009785_altered_susceptibility_to2.68847228
6MP0003195_calcinosis2.50117321
7MP0002148_abnormal_hypersensitivity_rea2.49915161
8MP0005058_abnormal_lysosome_morphology2.29218062
9MP0003724_increased_susceptibility_to2.15096594
10MP0000372_irregular_coat_pigmentation2.11187256
11MP0009333_abnormal_splenocyte_physiolog2.11015051
12MP0005000_abnormal_immune_tolerance1.98699814
13MP0006036_abnormal_mitochondrial_physio1.97170372
14MP0003436_decreased_susceptibility_to1.96459489
15MP0001853_heart_inflammation1.94073710
16MP0003191_abnormal_cellular_cholesterol1.94058536
17MP0001764_abnormal_homeostasis1.91089623
18MP0006082_CNS_inflammation1.84491787
19MP0005025_abnormal_response_to1.82201986
20MP0005075_abnormal_melanosome_morpholog1.80168570
21MP0009840_abnormal_foam_cell1.76629120
22MP0003786_premature_aging1.75003022
23MP0008875_abnormal_xenobiotic_pharmacok1.70756704
24MP0002419_abnormal_innate_immunity1.65698686
25MP0000685_abnormal_immune_system1.64783703
26MP0002723_abnormal_immune_serum1.63233296
27MP0003011_delayed_dark_adaptation1.60583117
28MP0005084_abnormal_gallbladder_morpholo1.59548470
29MP0002452_abnormal_antigen_presenting1.58709012
30MP0005464_abnormal_platelet_physiology1.58378244
31MP0002132_abnormal_respiratory_system1.56439433
32MP0005365_abnormal_bile_salt1.54310034
33MP0001845_abnormal_inflammatory_respons1.53396322
34MP0001790_abnormal_immune_system1.51762307
35MP0005387_immune_system_phenotype1.51762307
36MP0001819_abnormal_immune_cell1.50015854
37MP0002420_abnormal_adaptive_immunity1.49043619
38MP0008469_abnormal_protein_level1.48188637
39MP0001800_abnormal_humoral_immune1.47102694
40MP0003763_abnormal_thymus_physiology1.47088960
41MP0002277_abnormal_respiratory_mucosa1.46451262
42MP0002139_abnormal_hepatobiliary_system1.44480561
43MP0003075_altered_response_to1.44091604
44MP0001533_abnormal_skeleton_physiology1.41090976
45MP0001542_abnormal_bone_strength1.36954845
46MP0009764_decreased_sensitivity_to1.32733301
47MP0000516_abnormal_urinary_system1.31692400
48MP0005367_renal/urinary_system_phenotyp1.31692400
49MP0002163_abnormal_gland_morphology1.30613780
50MP0006054_spinal_hemorrhage1.30246226
51MP0005332_abnormal_amino_acid1.28663130
52MP0005165_increased_susceptibility_to1.28270137
53MP0002837_dystrophic_cardiac_calcinosis1.26757970
54MP0005360_urolithiasis1.25956131
55MP0002166_altered_tumor_susceptibility1.24778750
56MP0001545_abnormal_hematopoietic_system1.24016309
57MP0005397_hematopoietic_system_phenotyp1.24016309
58MP0002405_respiratory_system_inflammati1.23775111
59MP0010386_abnormal_urinary_bladder1.23747181
60MP0003866_abnormal_defecation1.22990759
61MP0008058_abnormal_DNA_repair1.22052989
62MP0005636_abnormal_mineral_homeostasis1.21098912
63MP0003718_maternal_effect1.18677732
64MP0010155_abnormal_intestine_physiology1.18292934
65MP0002006_tumorigenesis1.18230602
66MP0001873_stomach_inflammation1.18185355
67MP0005085_abnormal_gallbladder_physiolo1.17820182
68MP0000689_abnormal_spleen_morphology1.15205653
69MP0005379_endocrine/exocrine_gland_phen1.11978826
70MP0006072_abnormal_retinal_apoptosis1.10256582
71MP0000343_altered_response_to1.10195920
72MP0008872_abnormal_physiological_respon1.10098001
73MP0000465_gastrointestinal_hemorrhage1.09001382
74MP0009643_abnormal_urine_homeostasis1.07508299
75MP0000716_abnormal_immune_system1.07222029
76MP0005408_hypopigmentation1.06208026
77MP0002876_abnormal_thyroid_physiology1.04740395
78MP0006035_abnormal_mitochondrial_morpho1.03552910
79MP0009763_increased_sensitivity_to1.01415750
80MP0004019_abnormal_vitamin_homeostasis1.01279354
81MP0005319_abnormal_enzyme/_coenzyme0.98183968
82MP0002722_abnormal_immune_system0.97735893
83MP0000358_abnormal_cell_content/0.97664701
84MP0005310_abnormal_salivary_gland0.96711685
85MP0002429_abnormal_blood_cell0.96443816
86MP0002398_abnormal_bone_marrow0.95509833
87MP0001756_abnormal_urination0.93749037
88MP0009697_abnormal_copulation0.92896396
89MP0002254_reproductive_system_inflammat0.92809227
90MP0002693_abnormal_pancreas_physiology0.91164226
91MP0005410_abnormal_fertilization0.89724924
92MP0000858_altered_metastatic_potential0.89354364
93MP0005645_abnormal_hypothalamus_physiol0.86866406
94MP0001919_abnormal_reproductive_system0.86775021
95MP0005166_decreased_susceptibility_to0.86072920
96MP0005584_abnormal_enzyme/coenzyme_acti0.86046693
97MP0004147_increased_porphyrin_level0.85994836
98MP0010329_abnormal_lipoprotein_level0.85766467
99MP0009278_abnormal_bone_marrow0.81987155
100MP0005083_abnormal_biliary_tract0.79506403

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.51033139
2Acute necrotizing encephalopathy (HP:0006965)4.37479460
3Hepatocellular necrosis (HP:0001404)4.35162542
4Abnormal mitochondria in muscle tissue (HP:0008316)4.14905016
5Hepatic necrosis (HP:0002605)4.01217691
6Acute encephalopathy (HP:0006846)3.99500710
7Increased CSF lactate (HP:0002490)3.99052048
8Progressive macrocephaly (HP:0004481)3.72225960
9Elevated erythrocyte sedimentation rate (HP:0003565)3.64769083
10Type I transferrin isoform profile (HP:0003642)3.62706483
11Renal Fanconi syndrome (HP:0001994)3.41262698
12Increased hepatocellular lipid droplets (HP:0006565)3.39871831
13Lipid accumulation in hepatocytes (HP:0006561)3.29712827
143-Methylglutaconic aciduria (HP:0003535)3.16408616
15Stomatitis (HP:0010280)3.16191532
16Vacuolated lymphocytes (HP:0001922)3.14565550
17Abnormal protein glycosylation (HP:0012346)3.14369059
18Abnormal glycosylation (HP:0012345)3.14369059
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.14369059
20Abnormal protein N-linked glycosylation (HP:0012347)3.14369059
21Petechiae (HP:0000967)3.00875116
22Cerebral edema (HP:0002181)2.98585563
23Abnormality of liposaccharide metabolism (HP:0010968)2.93571715
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.93571715
25Abnormality of glycolipid metabolism (HP:0010969)2.93571715
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93531604
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93531604
28Increased intramyocellular lipid droplets (HP:0012240)2.87519195
29Lactic acidosis (HP:0003128)2.84708737
30Respiratory failure (HP:0002878)2.81422422
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.79061717
32Increased serum lactate (HP:0002151)2.72205478
33Aplastic anemia (HP:0001915)2.72127959
34Increased muscle lipid content (HP:0009058)2.67293980
35Exertional dyspnea (HP:0002875)2.66705839
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60140223
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59831257
38Methylmalonic aciduria (HP:0012120)2.53783871
39Reduced antithrombin III activity (HP:0001976)2.48872513
40Dicarboxylic aciduria (HP:0003215)2.43910008
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43910008
42Exercise intolerance (HP:0003546)2.40890822
43Lethargy (HP:0001254)2.40667257
44Methylmalonic acidemia (HP:0002912)2.35305293
45Hepatosplenomegaly (HP:0001433)2.33038173
46CNS demyelination (HP:0007305)2.32279572
47Myositis (HP:0100614)2.31203362
48Prolonged neonatal jaundice (HP:0006579)2.27536002
49Respiratory difficulties (HP:0002880)2.15819909
50Testicular atrophy (HP:0000029)2.15080132
51IgG deficiency (HP:0004315)2.10054126
52Pancytopenia (HP:0001876)2.08397271
53Abnormality of macrophages (HP:0004311)2.03098683
54Abnormality of urine glucose concentration (HP:0011016)2.02958045
55Glycosuria (HP:0003076)2.02958045
56Optic disc pallor (HP:0000543)2.02534247
57Systemic lupus erythematosus (HP:0002725)2.02066717
58Abnormal pupillary function (HP:0007686)2.01648919
59Progressive neurologic deterioration (HP:0002344)1.99984986
60Orchitis (HP:0100796)1.99729324
61Microvesicular hepatic steatosis (HP:0001414)1.98299829
62Abnormality of the anterior horn cell (HP:0006802)1.97732534
63Degeneration of anterior horn cells (HP:0002398)1.97732534
64Abnormality of methionine metabolism (HP:0010901)1.93256440
65Abnormality of renal resorption (HP:0011038)1.92538015
66Dysostosis multiplex (HP:0000943)1.91571307
67Loss of speech (HP:0002371)1.91505497
68Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91189809
69Ketoacidosis (HP:0001993)1.90189432
70Hypokinesia (HP:0002375)1.89277581
71Neutropenia (HP:0001875)1.86118068
72Retrobulbar optic neuritis (HP:0100654)1.85282329
73Optic neuritis (HP:0100653)1.85282329
74Emotional lability (HP:0000712)1.84911964
75Opisthotonus (HP:0002179)1.83372551
76Pustule (HP:0200039)1.83120383
77Severe combined immunodeficiency (HP:0004430)1.81743531
78Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81564822
79Abnormality of T cells (HP:0002843)1.80756263
80Abnormality of T cell physiology (HP:0011840)1.79287993
81Recurrent cutaneous fungal infections (HP:0011370)1.78700266
82Chronic mucocutaneous candidiasis (HP:0002728)1.78700266
83Generalized aminoaciduria (HP:0002909)1.77734550
84Rough bone trabeculation (HP:0100670)1.77680535
85Nausea (HP:0002018)1.76263169
86Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76232451
87Recurrent fungal infections (HP:0002841)1.75556806
88Anorexia (HP:0002039)1.75148983
89Progressive microcephaly (HP:0000253)1.74809124
90Hypoproteinemia (HP:0003075)1.74627634
91Hyperphosphaturia (HP:0003109)1.74446758
92Pancreatitis (HP:0001733)1.74249654
93Increased serum pyruvate (HP:0003542)1.73842768
94Microretrognathia (HP:0000308)1.73381931
95Sparse eyelashes (HP:0000653)1.71081694
96Tongue fasciculations (HP:0001308)1.69795507
97Purpura (HP:0000979)1.69458208
98Abnormality of vitamin B metabolism (HP:0004340)1.69298063
99Beaking of vertebral bodies (HP:0004568)1.67656100
100Abnormal spermatogenesis (HP:0008669)1.67380433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.65821838
2MST43.58455338
3TESK13.38485943
4TESK23.33284279
5NME23.08445072
6BCKDK2.95905315
7STK162.52605690
8TXK2.46430978
9MAP3K122.35693780
10LIMK12.18588243
11PIM22.10427510
12KDR2.01917551
13BUB11.72796401
14NUAK11.71694580
15MAP4K21.65948532
16PBK1.65416438
17EIF2AK31.62637389
18EIF2AK11.61194978
19VRK11.57752282
20ERN11.48462194
21TRIM281.42094620
22PDK21.39227950
23IKBKB1.38339748
24TBK11.35922641
25EPHA31.31614173
26MAP4K11.29249421
27ARAF1.26568942
28MAP3K31.26075619
29ZAK1.25558638
30MYLK1.23957099
31FRK1.20193987
32MAP3K111.19964678
33NME11.17918987
34TYK21.14982320
35GRK11.13269941
36ADRBK21.08965626
37EPHA21.08723738
38FER1.08604428
39ABL21.07501596
40DAPK11.06547317
41TAOK31.05788530
42SRPK11.02196709
43IKBKE0.96610356
44SCYL20.95368694
45TNK20.93254033
46GRK70.92897667
47GRK60.91204461
48EPHB10.90964723
49SIK30.84087884
50PAK40.83610793
51MUSK0.83265214
52ILK0.80365873
53TAOK20.78439982
54LMTK20.76451793
55MAPKAPK30.72139001
56TLK10.71105073
57TGFBR20.69853537
58NLK0.69180931
59NEK10.68977307
60KIT0.68627305
61IRAK30.68279659
62TEC0.67922657
63STK100.67353711
64FES0.66556924
65CSNK1G30.64400039
66JAK30.57538285
67RPS6KA50.57470974
68PLK30.57131023
69EIF2AK20.56192023
70ZAP700.55974998
71CDK190.55063778
72PRKCI0.54061507
73CSNK1G10.51262641
74DAPK30.50529964
75IRAK40.49900501
76ITK0.49195648
77LYN0.48513150
78PTK2B0.46634134
79MAPKAPK20.46310852
80BMPR1B0.45723765
81INSRR0.45720302
82FLT30.43041989
83CSF1R0.42639082
84STK40.42615471
85PAK10.40630905
86GRK50.39863653
87LRRK20.37064152
88BTK0.36709986
89CSK0.36588917
90LCK0.35866137
91CSNK2A10.34896426
92HIPK20.34590341
93ERBB30.34164553
94TIE10.33754917
95PRKCQ0.33294289
96CSNK2A20.32847616
97CSNK1A1L0.32539694
98MARK30.31635520
99OXSR10.31510426
100BMPR20.30951125

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.94277244
2Oxidative phosphorylation_Homo sapiens_hsa001903.66815296
3Parkinsons disease_Homo sapiens_hsa050122.88908908
4Protein export_Homo sapiens_hsa030602.77709619
5RNA polymerase_Homo sapiens_hsa030202.23479389
6Fatty acid elongation_Homo sapiens_hsa000622.20549554
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19924859
8Ribosome_Homo sapiens_hsa030101.95014283
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93050197
10Huntingtons disease_Homo sapiens_hsa050161.91058105
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86972631
12Glutathione metabolism_Homo sapiens_hsa004801.82856671
13Alzheimers disease_Homo sapiens_hsa050101.82595764
14Sulfur metabolism_Homo sapiens_hsa009201.75964546
15Primary immunodeficiency_Homo sapiens_hsa053401.57942676
16Antigen processing and presentation_Homo sapiens_hsa046121.52606042
17Folate biosynthesis_Homo sapiens_hsa007901.51768603
18Homologous recombination_Homo sapiens_hsa034401.46007514
19Collecting duct acid secretion_Homo sapiens_hsa049661.45540203
20Rheumatoid arthritis_Homo sapiens_hsa053231.44874436
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43408183
22Pyrimidine metabolism_Homo sapiens_hsa002401.42586015
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41657158
24Allograft rejection_Homo sapiens_hsa053301.40727704
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38626192
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33797442
27Graft-versus-host disease_Homo sapiens_hsa053321.31551060
28Type I diabetes mellitus_Homo sapiens_hsa049401.31271399
29Peroxisome_Homo sapiens_hsa041461.29779536
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21927449
31Autoimmune thyroid disease_Homo sapiens_hsa053201.21845006
32Base excision repair_Homo sapiens_hsa034101.21029740
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.20775795
34Mismatch repair_Homo sapiens_hsa034301.18679814
35DNA replication_Homo sapiens_hsa030301.08861864
36Asthma_Homo sapiens_hsa053101.08388802
37Propanoate metabolism_Homo sapiens_hsa006401.08321403
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07575496
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06860849
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06568530
41N-Glycan biosynthesis_Homo sapiens_hsa005101.05625818
42Other glycan degradation_Homo sapiens_hsa005111.05202632
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.03830200
44Lysosome_Homo sapiens_hsa041421.01930940
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.00908457
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96175968
47Chemical carcinogenesis_Homo sapiens_hsa052040.95187843
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94636016
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94199209
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93567046
51One carbon pool by folate_Homo sapiens_hsa006700.92437528
52Purine metabolism_Homo sapiens_hsa002300.87537918
53Sulfur relay system_Homo sapiens_hsa041220.86916582
54Metabolic pathways_Homo sapiens_hsa011000.86504549
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85218279
56Vibrio cholerae infection_Homo sapiens_hsa051100.85060215
57Caffeine metabolism_Homo sapiens_hsa002320.84992917
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84179398
59Regulation of autophagy_Homo sapiens_hsa041400.81710635
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.79645348
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79129322
62Galactose metabolism_Homo sapiens_hsa000520.75795044
63Legionellosis_Homo sapiens_hsa051340.74722753
64Arachidonic acid metabolism_Homo sapiens_hsa005900.73049004
65Fructose and mannose metabolism_Homo sapiens_hsa000510.72977157
66Butanoate metabolism_Homo sapiens_hsa006500.72942299
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.71061871
68Hematopoietic cell lineage_Homo sapiens_hsa046400.70247534
69Nucleotide excision repair_Homo sapiens_hsa034200.69782354
70RNA degradation_Homo sapiens_hsa030180.69575919
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.68212573
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68207705
73Staphylococcus aureus infection_Homo sapiens_hsa051500.66149809
74Carbon metabolism_Homo sapiens_hsa012000.65529026
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64930042
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62793882
77Non-homologous end-joining_Homo sapiens_hsa034500.61456649
78Pentose phosphate pathway_Homo sapiens_hsa000300.60970948
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.59708422
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57649026
81Tryptophan metabolism_Homo sapiens_hsa003800.55989074
82Mineral absorption_Homo sapiens_hsa049780.53650798
83Pyruvate metabolism_Homo sapiens_hsa006200.53357459
84Tyrosine metabolism_Homo sapiens_hsa003500.51283783
85Basal transcription factors_Homo sapiens_hsa030220.50561703
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49272721
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48478238
88Fatty acid degradation_Homo sapiens_hsa000710.48429015
89Cardiac muscle contraction_Homo sapiens_hsa042600.48210626
90Fatty acid metabolism_Homo sapiens_hsa012120.46803587
91Retinol metabolism_Homo sapiens_hsa008300.46612364
92beta-Alanine metabolism_Homo sapiens_hsa004100.46236961
93Fanconi anemia pathway_Homo sapiens_hsa034600.45888561
94Herpes simplex infection_Homo sapiens_hsa051680.45391319
95Pertussis_Homo sapiens_hsa051330.44889932
96Spliceosome_Homo sapiens_hsa030400.44503357
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.43871612
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42535780
99Malaria_Homo sapiens_hsa051440.42379450
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39716661

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