TMEM181

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)6.03768268
2negative regulation of fibrinolysis (GO:0051918)5.37352197
3plasma lipoprotein particle assembly (GO:0034377)5.34783723
4intestinal cholesterol absorption (GO:0030299)5.34365992
5protein-lipid complex assembly (GO:0065005)4.89537316
6regulation of fibrinolysis (GO:0051917)4.75076114
7intestinal absorption (GO:0050892)4.66488485
8low-density lipoprotein particle remodeling (GO:0034374)4.29047169
9protein carboxylation (GO:0018214)4.21873132
10peptidyl-glutamic acid carboxylation (GO:0017187)4.21873132
11regulation of apoptotic cell clearance (GO:2000425)4.21092733
12cholesterol efflux (GO:0033344)4.05788832
13regulation of protein activation cascade (GO:2000257)4.05767754
14regulation of complement activation (GO:0030449)4.03778375
15COPII vesicle coating (GO:0048208)3.93176355
16regulation of bile acid biosynthetic process (GO:0070857)3.75520067
17plasma lipoprotein particle organization (GO:0071827)3.75321966
18regulation of plasminogen activation (GO:0010755)3.69652224
19regulation of cholesterol homeostasis (GO:2000188)3.68406048
20protein-lipid complex remodeling (GO:0034368)3.67155031
21macromolecular complex remodeling (GO:0034367)3.67155031
22plasma lipoprotein particle remodeling (GO:0034369)3.67155031
23protein-lipid complex subunit organization (GO:0071825)3.60306457
24negative regulation of protein activation cascade (GO:2000258)3.56827157
25positive regulation of dendritic spine morphogenesis (GO:0061003)3.44295393
26cell adhesion mediated by integrin (GO:0033627)3.43779378
27regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.32743969
28chondrocyte proliferation (GO:0035988)3.24342656
29high-density lipoprotein particle remodeling (GO:0034375)3.24205052
30embryonic retina morphogenesis in camera-type eye (GO:0060059)3.21955286
31regulation of cholesterol esterification (GO:0010872)3.18464846
32regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.17771312
33negative regulation of complement activation (GO:0045916)3.09102578
34negative regulation of fatty acid transport (GO:2000192)3.04966555
35lipoprotein metabolic process (GO:0042157)3.03230738
36reverse cholesterol transport (GO:0043691)2.98864812
37skin morphogenesis (GO:0043589)2.91801682
38lipoprotein transport (GO:0042953)2.88117538
39desmosome organization (GO:0002934)2.87181146
40layer formation in cerebral cortex (GO:0021819)2.83843220
41cellular zinc ion homeostasis (GO:0006882)2.83638393
42regulation of non-canonical Wnt signaling pathway (GO:2000050)2.82856164
43cholesterol transport (GO:0030301)2.82788581
44sterol transport (GO:0015918)2.82788581
45vitamin transmembrane transport (GO:0035461)2.81377114
46regulation of cholesterol biosynthetic process (GO:0045540)2.80684477
47low-density lipoprotein particle clearance (GO:0034383)2.80646096
48plasma lipoprotein particle clearance (GO:0034381)2.77910003
49hemidesmosome assembly (GO:0031581)2.73486912
50endocardial cushion development (GO:0003197)2.71556791
51blood coagulation, intrinsic pathway (GO:0007597)2.66412182
52basement membrane organization (GO:0071711)2.66263999
53positive regulation of hormone biosynthetic process (GO:0046886)2.62769593
54positive regulation of blood coagulation (GO:0030194)2.62267659
55positive regulation of hemostasis (GO:1900048)2.62267659
56cellular response to prostaglandin stimulus (GO:0071379)2.60963974
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60050687
58COPI coating of Golgi vesicle (GO:0048205)2.57651155
59Golgi transport vesicle coating (GO:0048200)2.57651155
60neurotransmitter-gated ion channel clustering (GO:0072578)2.57449652
61regulation of extracellular matrix disassembly (GO:0010715)2.56056155
62nephron tubule morphogenesis (GO:0072078)2.52731525
63nephron epithelium morphogenesis (GO:0072088)2.52731525
64protein retention in ER lumen (GO:0006621)2.52543372
65negative regulation of sodium ion transport (GO:0010766)2.52138459
66sterol homeostasis (GO:0055092)2.51884948
67positive regulation of extracellular matrix organization (GO:1903055)2.50038343
68cholesterol homeostasis (GO:0042632)2.49878609
69response to hepatocyte growth factor (GO:0035728)2.48483785
70cellular response to hepatocyte growth factor stimulus (GO:0035729)2.48483785
71response to prostaglandin (GO:0034694)2.47941151
72glutamate metabolic process (GO:0006536)2.47420159
73positive regulation of coagulation (GO:0050820)2.46189126
74diacylglycerol metabolic process (GO:0046339)2.45375325
75positive regulation of insulin receptor signaling pathway (GO:0046628)2.42522128
76UDP-N-acetylglucosamine metabolic process (GO:0006047)2.41433930
77response to follicle-stimulating hormone (GO:0032354)2.40712048
78C4-dicarboxylate transport (GO:0015740)2.40618654
79embryonic process involved in female pregnancy (GO:0060136)2.40520195
80embryonic foregut morphogenesis (GO:0048617)2.39999553
81positive regulation of steroid metabolic process (GO:0045940)2.39853140
82renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.38605765
83positive regulation of hormone metabolic process (GO:0032352)2.38218400
84lung epithelium development (GO:0060428)2.37983237
85vesicle coating (GO:0006901)2.35150817
86regulation of steroid hormone biosynthetic process (GO:0090030)2.34618352
87positive regulation of collagen biosynthetic process (GO:0032967)2.34490433
88regulation of extracellular matrix organization (GO:1903053)2.33184728
89nuclear pore complex assembly (GO:0051292)2.33005922
90drinking behavior (GO:0042756)2.31624705
91drug transmembrane transport (GO:0006855)2.29756025
92peristalsis (GO:0030432)2.29735088
93negative regulation of lipase activity (GO:0060192)2.28927103
94bundle of His cell to Purkinje myocyte communication (GO:0086069)2.27781614
95retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26771191
96lipid homeostasis (GO:0055088)2.25602093
97negative regulation of sterol transport (GO:0032372)2.25490644
98negative regulation of cholesterol transport (GO:0032375)2.25490644
99renal tubule morphogenesis (GO:0061333)2.24569290
100receptor catabolic process (GO:0032801)2.23626001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.29240300
2* FOXA2_19822575_ChIP-Seq_HepG2_Human3.05278900
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76931954
4CDX2_19796622_ChIP-Seq_MESCs_Mouse2.75335109
5TCF4_18268006_ChIP-ChIP_LS174T_Human2.51968045
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.31941437
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.26564751
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26195578
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.24829023
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.24356404
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.22165173
12FOXO3_23340844_ChIP-Seq_DLD1_Human2.16774651
13SALL4_18804426_ChIP-ChIP_XEN_Mouse2.10127777
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.09741066
15CLOCK_20551151_ChIP-Seq_293T_Human2.04301756
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02120194
17* HNF4A_19822575_ChIP-Seq_HepG2_Human1.96962599
18RXR_22158963_ChIP-Seq_LIVER_Mouse1.94270204
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.90917896
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.90614499
21CTNNB1_20460455_ChIP-Seq_HCT116_Human1.88634785
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.87347989
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86037403
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.80970596
25AR_21909140_ChIP-Seq_LNCAP_Human1.76879313
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74746732
27TP53_16413492_ChIP-PET_HCT116_Human1.71418887
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70148091
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69796368
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66478510
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65411549
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58107602
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57134717
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.55590080
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54069580
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54069580
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51907937
38GATA4_25053715_ChIP-Seq_YYC3_Human1.50279457
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45960782
40* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45477171
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44968715
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.42898304
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42773523
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41992927
45PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41980723
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40276182
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39680376
48CJUN_26792858_Chip-Seq_BT549_Human1.39459915
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37909730
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35786230
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33642198
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.30139756
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28210741
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.28207904
55SOX2_20726797_ChIP-Seq_SW620_Human1.27809743
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26908642
57GBX2_23144817_ChIP-Seq_PC3_Human1.26550956
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25969798
59AHR_22903824_ChIP-Seq_MCF-7_Human1.24122491
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21593854
61TP53_18474530_ChIP-ChIP_U2OS_Human1.20738916
62BRD4_25478319_ChIP-Seq_HGPS_Human1.19730603
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.19394301
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.19289496
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18875364
66AR_21572438_ChIP-Seq_LNCaP_Human1.18089296
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17375030
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17348903
69ZNF263_19887448_ChIP-Seq_K562_Human1.16134351
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12760307
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12009637
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11634341
73STAT3_23295773_ChIP-Seq_U87_Human1.11106238
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10503324
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08465755
76GATA6_25053715_ChIP-Seq_YYC3_Human1.08114943
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08091307
78FOXA1_25552417_ChIP-Seq_VCAP_Human1.07959648
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07733682
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06741742
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06716102
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05704817
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05672095
84TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04861479
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04584675
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02953341
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.02461171
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02159859
89TP63_23658742_ChIP-Seq_EP156T_Human1.01089594
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00813818
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00199131
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.99539914
93CMYC_18555785_Chip-Seq_ESCs_Mouse0.99313794
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.97919354
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97234796
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95959905
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95841786
98* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95145775
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94871928
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94841781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.18014549
2MP0008438_abnormal_cutaneous_collagen3.65262235
3MP0003195_calcinosis3.24000999
4MP0005360_urolithiasis3.05692856
5MP0004272_abnormal_basement_membrane3.03365338
6MP0010368_abnormal_lymphatic_system2.87047349
7MP0001666_abnormal_nutrient_absorption2.85211664
8MP0005365_abnormal_bile_salt2.76800189
9MP0005409_darkened_coat_color2.75942346
10MP0002139_abnormal_hepatobiliary_system2.71071876
11MP0003123_paternal_imprinting2.70886735
12MP0009780_abnormal_chondrocyte_physiolo2.52463832
13MP0005085_abnormal_gallbladder_physiolo2.43301538
14MP0003868_abnormal_feces_composition2.36992179
15MP0003941_abnormal_skin_development2.34842033
16MP0005257_abnormal_intraocular_pressure2.32614189
17MP0010329_abnormal_lipoprotein_level2.30000689
18MP0006054_spinal_hemorrhage2.15167204
19MP0010234_abnormal_vibrissa_follicle2.15150948
20MP0000566_synostosis1.98834259
21MP0010352_gastrointestinal_tract_polyps1.91777412
22MP0003890_abnormal_embryonic-extraembry1.86453671
23MP0003121_genomic_imprinting1.79943853
24MP0001915_intracranial_hemorrhage1.77173010
25MP0003566_abnormal_cell_adhesion1.73776684
26MP0003705_abnormal_hypodermis_morpholog1.65510872
27MP0003252_abnormal_bile_duct1.61936885
28MP0005408_hypopigmentation1.60971206
29MP0009384_cardiac_valve_regurgitation1.56298592
30MP0000013_abnormal_adipose_tissue1.48426780
31MP0002089_abnormal_postnatal_growth/wei1.46950408
32MP0003172_abnormal_lysosome_physiology1.40826205
33MP0003950_abnormal_plasma_membrane1.38442902
34MP0003183_abnormal_peptide_metabolism1.38292864
35MP0003115_abnormal_respiratory_system1.32602765
36MP0002896_abnormal_bone_mineralization1.31868150
37MP0003385_abnormal_body_wall1.31781411
38MP0004264_abnormal_extraembryonic_tissu1.30080605
39MP0002909_abnormal_adrenal_gland1.29640509
40MP0004270_analgesia1.26340284
41MP0001270_distended_abdomen1.21711714
42MP0003567_abnormal_fetal_cardiomyocyte1.17088127
43MP0005451_abnormal_body_composition1.12660131
44MP0003283_abnormal_digestive_organ1.11132706
45MP0001299_abnormal_eye_distance/1.06886095
46MP0000003_abnormal_adipose_tissue1.06364361
47MP0005275_abnormal_skin_tensile1.06345726
48MP0005076_abnormal_cell_differentiation1.05695388
49MP0000534_abnormal_ureter_morphology1.01279957
50MP0003315_abnormal_perineum_morphology1.00790899
51MP0001661_extended_life_span0.99562398
52MP0003942_abnormal_urinary_system0.95127309
53MP0002697_abnormal_eye_size0.95016764
54MP0003937_abnormal_limbs/digits/tail_de0.93282827
55MP0003943_abnormal_hepatobiliary_system0.92605601
56MP0000639_abnormal_adrenal_gland0.91747456
57MP0009697_abnormal_copulation0.91178029
58MP0000767_abnormal_smooth_muscle0.90639980
59MP0000762_abnormal_tongue_morphology0.89317812
60MP0004858_abnormal_nervous_system0.89148791
61MP0002086_abnormal_extraembryonic_tissu0.88280827
62MP0002118_abnormal_lipid_homeostasis0.85041434
63MP0003091_abnormal_cell_migration0.83948737
64MP0003935_abnormal_craniofacial_develop0.83891216
65MP0003632_abnormal_nervous_system0.83826533
66MP0002060_abnormal_skin_morphology0.82301107
67MP0000609_abnormal_liver_physiology0.76995516
68MP0002233_abnormal_nose_morphology0.74481061
69MP0002092_abnormal_eye_morphology0.74444397
70MP0002938_white_spotting0.74071633
71MP0008875_abnormal_xenobiotic_pharmacok0.73749093
72MP0005220_abnormal_exocrine_pancreas0.73628881
73MP0002925_abnormal_cardiovascular_devel0.73018881
74MP0000432_abnormal_head_morphology0.71743225
75MP0004043_abnormal_pH_regulation0.71243021
76MP0001879_abnormal_lymphatic_vessel0.70922361
77MP0002160_abnormal_reproductive_system0.69890149
78MP0000428_abnormal_craniofacial_morphol0.69419811
79MP0005058_abnormal_lysosome_morphology0.69185251
80MP0004134_abnormal_chest_morphology0.68879621
81MP0003984_embryonic_growth_retardation0.68738964
82MP0002084_abnormal_developmental_patter0.68149991
83MP0009840_abnormal_foam_cell0.68141510
84MP0003755_abnormal_palate_morphology0.67872423
85MP0002088_abnormal_embryonic_growth/wei0.66505067
86MP0005023_abnormal_wound_healing0.65248918
87MP0003119_abnormal_digestive_system0.64912105
88MP0005187_abnormal_penis_morphology0.64218271
89MP0005623_abnormal_meninges_morphology0.63577782
90MP0001286_abnormal_eye_development0.62760038
91MP0010678_abnormal_skin_adnexa0.62487557
92MP0002168_other_aberrant_phenotype0.62090086
93MP0001672_abnormal_embryogenesis/_devel0.61844599
94MP0005380_embryogenesis_phenotype0.61844599
95MP0002109_abnormal_limb_morphology0.60657662
96MP0000462_abnormal_digestive_system0.60406557
97MP0002128_abnormal_blood_circulation0.58467903
98MP0005367_renal/urinary_system_phenotyp0.58322661
99MP0000516_abnormal_urinary_system0.58322661
100MP0000569_abnormal_digit_pigmentation0.58018485

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.38527726
2Hypobetalipoproteinemia (HP:0003563)4.10324710
3Prolonged partial thromboplastin time (HP:0003645)4.09727796
4Protrusio acetabuli (HP:0003179)3.86392822
5Flat acetabular roof (HP:0003180)3.78827979
6Asymmetry of the thorax (HP:0001555)3.66732941
7Abnormality of the common coagulation pathway (HP:0010990)3.52836539
8Acanthocytosis (HP:0001927)3.50106136
9Abnormality of carpal bone ossification (HP:0006257)3.43461448
10Arterial tortuosity (HP:0005116)3.19555985
11Small epiphyses (HP:0010585)3.19335609
12Broad palm (HP:0001169)3.10892203
13Epidermoid cyst (HP:0200040)3.05113632
14Premature rupture of membranes (HP:0001788)2.94122844
15Hypercholesterolemia (HP:0003124)2.92275292
16Abnormal tarsal ossification (HP:0008369)2.90685984
17Vascular tortuosity (HP:0004948)2.84776424
18Cardiovascular calcification (HP:0011915)2.79644478
19Joint hemorrhage (HP:0005261)2.77834311
20Vascular calcification (HP:0004934)2.74496463
21Complement deficiency (HP:0004431)2.74030726
22Abnormal ossification of hand bones (HP:0005921)2.68048930
23Abnormal hand bone ossification (HP:0010660)2.65983144
24Hemorrhage of the eye (HP:0011885)2.63363171
25Hepatoblastoma (HP:0002884)2.62340581
26Papillary thyroid carcinoma (HP:0002895)2.58953213
27Xanthomatosis (HP:0000991)2.57687007
28Mitral stenosis (HP:0001718)2.56763880
29Epiphyseal dysplasia (HP:0002656)2.55656740
30Hypolipoproteinemia (HP:0010981)2.51959005
31Broad alveolar ridges (HP:0000187)2.51339062
32Abnormal foot bone ossification (HP:0010675)2.47971607
33Abnormality of the nasal septum (HP:0000419)2.43901150
34Abnormality of the acetabulum (HP:0003170)2.41427446
35Skin nodule (HP:0200036)2.35953248
36Pancreatic islet-cell hyperplasia (HP:0004510)2.33725466
37Aortic dissection (HP:0002647)2.32384730
38Neonatal short-limb short stature (HP:0008921)2.31602523
39Abnormality of proline metabolism (HP:0010907)2.26071530
40Hydroxyprolinuria (HP:0003080)2.26071530
41Menorrhagia (HP:0000132)2.25994258
42Abnormality of the wing of the ilium (HP:0011867)2.24569037
43Renal duplication (HP:0000075)2.21214304
44Limited elbow extension (HP:0001377)2.17080399
45Conjugated hyperbilirubinemia (HP:0002908)2.15207457
46Scanning speech (HP:0002168)2.13792340
47Fat malabsorption (HP:0002630)2.12563514
48Cupped ribs (HP:0000887)2.11958762
49Cerebral aneurysm (HP:0004944)2.10627394
50Arthropathy (HP:0003040)2.09301100
51Hypoglycemic coma (HP:0001325)2.09040329
52Coxa vara (HP:0002812)2.07957785
53Abnormality of the lumbar spine (HP:0100712)2.06731359
54Glomerulonephritis (HP:0000099)2.04921784
55Abnormality of dentin (HP:0010299)2.00511258
56Atrophic scars (HP:0001075)1.99059801
57Flared iliac wings (HP:0002869)1.98425103
58Vertebral arch anomaly (HP:0008438)1.97843890
59Coarse hair (HP:0002208)1.96153540
60Abnormality of pain sensation (HP:0010832)1.95974901
61Impaired pain sensation (HP:0007328)1.95974901
62Wide nose (HP:0000445)1.94936953
63Peritonitis (HP:0002586)1.94496107
64Abnormality of complement system (HP:0005339)1.93440116
65Hypoglycemic seizures (HP:0002173)1.92511138
66Exotropia (HP:0000577)1.90769561
67Overlapping toe (HP:0001845)1.90244031
68Wormian bones (HP:0002645)1.89910882
69Abnormality of the pancreatic islet cells (HP:0006476)1.88201570
70Abnormality of endocrine pancreas physiology (HP:0012093)1.88201570
71Ankyloglossia (HP:0010296)1.85990387
72Heterotopia (HP:0002282)1.81924208
73Insidious onset (HP:0003587)1.81314878
74Termporal pattern (HP:0011008)1.81314878
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80555067
76Soft skin (HP:0000977)1.80459522
77Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79529684
78Right ventricular cardiomyopathy (HP:0011663)1.77379922
79Thyroid carcinoma (HP:0002890)1.76718497
80Alacrima (HP:0000522)1.73659678
81Ovoid vertebral bodies (HP:0003300)1.72853930
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72307952
83Enlarged kidneys (HP:0000105)1.72028546
84Bladder diverticulum (HP:0000015)1.70814526
85Hypophosphatemic rickets (HP:0004912)1.67701569
86Irregular epiphyses (HP:0010582)1.67252976
87Neonatal death (HP:0003811)1.65593315
88Abnormality of the intrinsic pathway (HP:0010989)1.65501225
89Rectal prolapse (HP:0002035)1.65435313
90Hypothermia (HP:0002045)1.65265005
91Abnormality of glutamine family amino acid metabolism (HP:0010902)1.65186294
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64752564
93Bilateral sensorineural hearing impairment (HP:0008619)1.63867047
94Metaphyseal irregularity (HP:0003025)1.62815015
95Diastasis recti (HP:0001540)1.62787442
96Back pain (HP:0003418)1.61919879
97Decreased lacrimation (HP:0000633)1.61558797
98Advanced eruption of teeth (HP:0006288)1.61523884
99Thickened calvaria (HP:0002684)1.60615120
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60594371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR33.94184754
2FGFR43.63305582
3LATS13.12306960
4PDGFRA3.10005909
5CDK122.74017150
6ICK2.60299542
7WNK42.40538281
8AKT32.37847124
9RIPK12.27005426
10FGFR22.06987825
11MST1R1.93044458
12MAP3K61.92130651
13TYRO31.89670860
14PIK3CA1.89470658
15MAP3K21.81618823
16PKN21.79734973
17MAP3K41.79476354
18NTRK11.69201521
19CASK1.69091951
20RET1.67351090
21FGFR11.65485027
22MET1.63044514
23EEF2K1.62833711
24WNK11.53160918
25KSR21.36535881
26NTRK31.35050791
27TRIB31.34787695
28STK391.33519132
29BCR1.32363040
30PTK21.31738558
31LATS21.29079002
32TRPM71.26385377
33FRK1.23534361
34PRKAA21.21466378
35DDR21.21154419
36BRD41.18688217
37PDGFRB1.18131988
38ERBB31.16667458
39TGFBR21.14483051
40CAMK1G1.12451978
41CAMK1D1.10780617
42EPHA21.03283386
43STK380.99421614
44MAP2K40.97407800
45ERBB20.94149074
46BRSK20.86529639
47SGK4940.86520328
48SGK2230.86520328
49FLT30.83955333
50ERBB40.83683227
51SGK30.82640830
52EPHA30.80777634
53NEK90.78625251
54STK38L0.77810420
55SGK20.77338443
56CDC42BPA0.77297528
57YES10.74324608
58KSR10.73801754
59MAP2K70.72756854
60SGK10.72001933
61LMTK20.70880262
62SIK20.70704846
63MARK10.69979351
64STK30.69599356
65PRKAA10.68687891
66FER0.62344828
67DYRK1B0.61955685
68CDK60.61299650
69ACVR1B0.60787868
70MAP3K70.58601767
71NTRK20.58510799
72RPS6KB10.57805117
73MTOR0.56030478
74CSNK1E0.55219077
75PTK60.55019008
76SCYL20.53347402
77NEK20.52492618
78MAPK110.52200265
79TIE10.51497708
80EPHA40.50710324
81MELK0.50531904
82PRKG20.49666732
83CAMKK20.47009837
84EIF2AK10.46595343
85PDPK10.40763944
86NLK0.40126267
87MAP3K50.39133021
88CSNK1D0.38462280
89PAK20.37261208
90ERN10.35477280
91MARK20.35326546
92EIF2AK30.34884033
93NEK60.34722283
94MAPK100.31389464
95SRC0.30696121
96PRKCE0.28560842
97MAPKAPK30.28448608
98RPS6KA30.28221292
99MAP2K10.27445307
100CSNK1A1L0.25178369

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.18316090
2Fat digestion and absorption_Homo sapiens_hsa049752.50847015
3Fatty acid biosynthesis_Homo sapiens_hsa000612.33516550
4Vitamin digestion and absorption_Homo sapiens_hsa049772.00195568
5Maturity onset diabetes of the young_Homo sapiens_hsa049501.97164731
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.65062813
7ECM-receptor interaction_Homo sapiens_hsa045121.59648011
8Arginine biosynthesis_Homo sapiens_hsa002201.59116061
9Renin-angiotensin system_Homo sapiens_hsa046141.50402332
10PPAR signaling pathway_Homo sapiens_hsa033201.49044259
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48403214
12Steroid biosynthesis_Homo sapiens_hsa001001.48186496
13Starch and sucrose metabolism_Homo sapiens_hsa005001.47457245
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46875980
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.40770073
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39972489
17Fatty acid metabolism_Homo sapiens_hsa012121.32616366
18Adherens junction_Homo sapiens_hsa045201.30326666
19Bile secretion_Homo sapiens_hsa049761.27515689
20N-Glycan biosynthesis_Homo sapiens_hsa005101.23258707
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23034326
22Protein digestion and absorption_Homo sapiens_hsa049741.21710373
23Histidine metabolism_Homo sapiens_hsa003401.21464293
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19895358
25Thyroid hormone synthesis_Homo sapiens_hsa049181.19579227
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15282438
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13871626
28ABC transporters_Homo sapiens_hsa020101.12290451
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.09681076
30Fatty acid degradation_Homo sapiens_hsa000711.05781370
31Focal adhesion_Homo sapiens_hsa045101.02442973
32Other glycan degradation_Homo sapiens_hsa005111.01164624
33Lysine degradation_Homo sapiens_hsa003101.00857097
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97627453
35Vitamin B6 metabolism_Homo sapiens_hsa007500.96692493
36Sphingolipid metabolism_Homo sapiens_hsa006000.92372271
37Circadian rhythm_Homo sapiens_hsa047100.92274503
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87723703
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86336187
40Choline metabolism in cancer_Homo sapiens_hsa052310.85118915
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84666220
42Insulin resistance_Homo sapiens_hsa049310.84287227
43Proteoglycans in cancer_Homo sapiens_hsa052050.83760402
44Glycerolipid metabolism_Homo sapiens_hsa005610.80872170
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80449523
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80322770
47Mineral absorption_Homo sapiens_hsa049780.79892374
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79214789
49mTOR signaling pathway_Homo sapiens_hsa041500.78538802
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.78116952
51Inositol phosphate metabolism_Homo sapiens_hsa005620.77306244
52Endometrial cancer_Homo sapiens_hsa052130.77032521
53Small cell lung cancer_Homo sapiens_hsa052220.76346426
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75917633
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75036240
56TGF-beta signaling pathway_Homo sapiens_hsa043500.74616588
57Arginine and proline metabolism_Homo sapiens_hsa003300.72739981
58Glucagon signaling pathway_Homo sapiens_hsa049220.70194454
59Non-small cell lung cancer_Homo sapiens_hsa052230.70039865
60Butanoate metabolism_Homo sapiens_hsa006500.69976146
61ErbB signaling pathway_Homo sapiens_hsa040120.68388044
62Type II diabetes mellitus_Homo sapiens_hsa049300.68151928
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.64535835
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64119214
65AMPK signaling pathway_Homo sapiens_hsa041520.63549663
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62852147
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.62387340
68Pancreatic cancer_Homo sapiens_hsa052120.61569571
69Chronic myeloid leukemia_Homo sapiens_hsa052200.61141583
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61122173
71Thyroid cancer_Homo sapiens_hsa052160.60676815
72Insulin signaling pathway_Homo sapiens_hsa049100.60565418
73Axon guidance_Homo sapiens_hsa043600.60136434
74Hippo signaling pathway_Homo sapiens_hsa043900.60071871
75Prolactin signaling pathway_Homo sapiens_hsa049170.58396934
76Glioma_Homo sapiens_hsa052140.58080546
77MicroRNAs in cancer_Homo sapiens_hsa052060.57897485
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.57507413
79FoxO signaling pathway_Homo sapiens_hsa040680.56011321
80Propanoate metabolism_Homo sapiens_hsa006400.55543340
81Ether lipid metabolism_Homo sapiens_hsa005650.54964235
82GnRH signaling pathway_Homo sapiens_hsa049120.52756291
83Pancreatic secretion_Homo sapiens_hsa049720.52713207
84Renin secretion_Homo sapiens_hsa049240.52689072
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52157541
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51946670
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51503339
88Prion diseases_Homo sapiens_hsa050200.51310819
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50713020
90Glutamatergic synapse_Homo sapiens_hsa047240.50434889
91Retinol metabolism_Homo sapiens_hsa008300.49215915
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48815290
93Galactose metabolism_Homo sapiens_hsa000520.47896287
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47582788
95Tight junction_Homo sapiens_hsa045300.47403804
96Long-term potentiation_Homo sapiens_hsa047200.46697611
97Long-term depression_Homo sapiens_hsa047300.46232417
98Prostate cancer_Homo sapiens_hsa052150.46159113
99Fructose and mannose metabolism_Homo sapiens_hsa000510.45403789
100Dorso-ventral axis formation_Homo sapiens_hsa043200.45057668

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