TMEM183A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.41714823
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.41714823
3L-phenylalanine metabolic process (GO:0006558)6.40394490
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.40394490
5aromatic amino acid family catabolic process (GO:0009074)5.74320660
6cysteine metabolic process (GO:0006534)5.59770714
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50452664
8urea cycle (GO:0000050)5.33775294
9urea metabolic process (GO:0019627)5.33775294
10kynurenine metabolic process (GO:0070189)5.21076557
11tryptophan catabolic process (GO:0006569)5.12166975
12indole-containing compound catabolic process (GO:0042436)5.12166975
13indolalkylamine catabolic process (GO:0046218)5.12166975
14glyoxylate metabolic process (GO:0046487)5.11519488
15glycine metabolic process (GO:0006544)5.10416188
16sulfur amino acid catabolic process (GO:0000098)5.04325939
17nuclear pore complex assembly (GO:0051292)5.03475895
18serine family amino acid catabolic process (GO:0009071)5.02971573
19homocysteine metabolic process (GO:0050667)4.99661454
20bile acid biosynthetic process (GO:0006699)4.99147765
21negative regulation of fibrinolysis (GO:0051918)4.98170116
22alpha-linolenic acid metabolic process (GO:0036109)4.95239412
23tryptophan metabolic process (GO:0006568)4.93092711
24high-density lipoprotein particle remodeling (GO:0034375)4.82433490
25nitrogen cycle metabolic process (GO:0071941)4.80962342
26lysine metabolic process (GO:0006553)4.76207346
27lysine catabolic process (GO:0006554)4.76207346
28DNA unwinding involved in DNA replication (GO:0006268)4.75185736
29formation of translation preinitiation complex (GO:0001731)4.71056208
30serine family amino acid biosynthetic process (GO:0009070)4.64029949
31serine family amino acid metabolic process (GO:0009069)4.58008475
32regulation of fibrinolysis (GO:0051917)4.54951492
33negative regulation of cholesterol transport (GO:0032375)4.54421451
34negative regulation of sterol transport (GO:0032372)4.54421451
35nuclear pore organization (GO:0006999)4.54271264
36regulation of protein activation cascade (GO:2000257)4.50193985
37peptidyl-glutamic acid carboxylation (GO:0017187)4.37520226
38protein carboxylation (GO:0018214)4.37520226
39aromatic amino acid family metabolic process (GO:0009072)4.35416542
40bile acid metabolic process (GO:0008206)4.33249926
41bile acid and bile salt transport (GO:0015721)4.30346896
42complement activation, alternative pathway (GO:0006957)4.29341649
43reverse cholesterol transport (GO:0043691)4.20874124
44regulation of complement activation (GO:0030449)4.20041427
45alpha-amino acid catabolic process (GO:1901606)4.18370378
46tyrosine metabolic process (GO:0006570)4.17228675
47imidazole-containing compound metabolic process (GO:0052803)4.16231399
48ribosomal small subunit biogenesis (GO:0042274)4.12921467
49ribosomal small subunit assembly (GO:0000028)4.10032722
50one-carbon metabolic process (GO:0006730)4.05485966
51regulation of triglyceride catabolic process (GO:0010896)4.04126938
52plasma lipoprotein particle remodeling (GO:0034369)4.04083310
53protein-lipid complex remodeling (GO:0034368)4.04083310
54macromolecular complex remodeling (GO:0034367)4.04083310
55nucleobase-containing small molecule interconversion (GO:0015949)4.02157235
56protein complex localization (GO:0031503)4.00326836
57amino-acid betaine metabolic process (GO:0006577)3.98630911
58acylglycerol homeostasis (GO:0055090)3.97687694
59triglyceride homeostasis (GO:0070328)3.97687694
60cellular modified amino acid catabolic process (GO:0042219)3.96040157
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.95821806
62regulation of translational fidelity (GO:0006450)3.94972422
63DNA strand elongation involved in DNA replication (GO:0006271)3.93946438
64cellular ketone body metabolic process (GO:0046950)3.91933806
65peptidyl-arginine omega-N-methylation (GO:0035247)3.91245746
66glutamate metabolic process (GO:0006536)3.89576294
67cellular amino acid catabolic process (GO:0009063)3.88780770
68DNA strand elongation (GO:0022616)3.88440451
69regulation of cholesterol esterification (GO:0010872)3.85687983
70establishment of integrated proviral latency (GO:0075713)3.85005991
71Golgi transport vesicle coating (GO:0048200)3.84107738
72COPI coating of Golgi vesicle (GO:0048205)3.84107738
73folic acid metabolic process (GO:0046655)3.78066696
74pore complex assembly (GO:0046931)3.77861065
75folic acid-containing compound biosynthetic process (GO:0009396)3.74659692
76drug catabolic process (GO:0042737)3.71205437
77ethanol oxidation (GO:0006069)3.69739467
78histone arginine methylation (GO:0034969)3.66885443
79cellular glucuronidation (GO:0052695)3.65937026
80phospholipid efflux (GO:0033700)3.65565908
81arginine metabolic process (GO:0006525)3.63859395
82intestinal cholesterol absorption (GO:0030299)3.63247722
83negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.63124611
84viral transcription (GO:0019083)3.61913303
85tetrahydrofolate metabolic process (GO:0046653)3.61637877
86plasma lipoprotein particle clearance (GO:0034381)3.61022462
87proline biosynthetic process (GO:0006561)3.60992573
88regulation of cholesterol homeostasis (GO:2000188)3.60327425
89indolalkylamine metabolic process (GO:0006586)3.59362248
90maturation of SSU-rRNA (GO:0030490)3.56991911
91benzene-containing compound metabolic process (GO:0042537)3.54261001
92mitotic chromosome condensation (GO:0007076)3.54103682
93ribosomal large subunit biogenesis (GO:0042273)3.53539207
94dicarboxylic acid biosynthetic process (GO:0043650)3.52177932
95DNA replication initiation (GO:0006270)3.51176475
96translational termination (GO:0006415)3.49645717
97plasma lipoprotein particle assembly (GO:0034377)3.48932656
98ribosome assembly (GO:0042255)3.48221215
99cellular protein complex localization (GO:0034629)3.46303510
100aldehyde catabolic process (GO:0046185)3.45806260
101coenzyme catabolic process (GO:0009109)3.45465705
102ketone body metabolic process (GO:1902224)3.44532473
103urate metabolic process (GO:0046415)3.42562932
104L-serine metabolic process (GO:0006563)3.41895441
105ribonucleoprotein complex biogenesis (GO:0022613)3.40831009
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40549818
107spliceosomal tri-snRNP complex assembly (GO:0000244)3.39453493
108cholesterol efflux (GO:0033344)3.37544162
109response to nitrosative stress (GO:0051409)3.37249086
110cellular biogenic amine catabolic process (GO:0042402)3.32028042
111amine catabolic process (GO:0009310)3.32028042
112negative regulation of fatty acid biosynthetic process (GO:0045717)3.30428085
113acetyl-CoA metabolic process (GO:0006084)3.30212648
114telomere maintenance via semi-conservative replication (GO:0032201)3.30049171
115drug transmembrane transport (GO:0006855)3.28647162
116pyrimidine nucleobase catabolic process (GO:0006208)3.28061635
117translational initiation (GO:0006413)3.25931843
118lipoprotein metabolic process (GO:0042157)3.24980875
119purine nucleobase biosynthetic process (GO:0009113)3.23321028
120cholesterol homeostasis (GO:0042632)3.23017707
121regulation of bile acid biosynthetic process (GO:0070857)3.22797437
122ribosome biogenesis (GO:0042254)3.22542269
123mitotic sister chromatid segregation (GO:0000070)3.22500557
124peptidyl-arginine methylation (GO:0018216)3.21654367
125peptidyl-arginine N-methylation (GO:0035246)3.21654367
126IMP biosynthetic process (GO:0006188)3.21580084
127glucuronate metabolic process (GO:0019585)3.21540748
128uronic acid metabolic process (GO:0006063)3.21540748
129sterol homeostasis (GO:0055092)3.21419687
130organic acid catabolic process (GO:0016054)3.21086107
131carboxylic acid catabolic process (GO:0046395)3.21086107
132fibrinolysis (GO:0042730)3.20335517
1332-oxoglutarate metabolic process (GO:0006103)3.19836238
134translational elongation (GO:0006414)3.19821807
135heme transport (GO:0015886)3.19332014
136very-low-density lipoprotein particle assembly (GO:0034379)3.18698519
137negative regulation of RNA splicing (GO:0033119)3.18564837
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18286434
139aspartate family amino acid catabolic process (GO:0009068)3.18279607
140negative regulation of mRNA processing (GO:0050686)3.17685482
141intestinal absorption (GO:0050892)3.17437425
142positive regulation of lipoprotein lipase activity (GO:0051006)3.15849199
143mitotic metaphase plate congression (GO:0007080)3.15474757
144protein localization to chromosome, centromeric region (GO:0071459)3.14035769
145establishment of viral latency (GO:0019043)3.13245009
146cotranslational protein targeting to membrane (GO:0006613)3.11368002
147protein targeting to ER (GO:0045047)3.09707406
148regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08681859
149tRNA aminoacylation for protein translation (GO:0006418)3.07926675
150negative regulation of mRNA metabolic process (GO:1903312)3.06757733
151mitotic nuclear envelope disassembly (GO:0007077)3.06202858
152viral life cycle (GO:0019058)3.05095644
153protein export from nucleus (GO:0006611)3.04929027
154tRNA aminoacylation (GO:0043039)3.00074845
155amino acid activation (GO:0043038)3.00074845
156regulation of mammary gland epithelial cell proliferation (GO:0033599)2.99544592
157establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98793206
158viral mRNA export from host cell nucleus (GO:0046784)2.97987225
159regulation of translational termination (GO:0006449)2.97481327
160sister chromatid segregation (GO:0000819)2.96136482
161protein localization to endoplasmic reticulum (GO:0070972)2.93358884
162DNA topological change (GO:0006265)2.92306929
163membrane disassembly (GO:0030397)2.90641145
164nuclear envelope disassembly (GO:0051081)2.90641145
165cellular protein complex disassembly (GO:0043624)2.90521050
166positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.90082613
167IMP metabolic process (GO:0046040)2.89756680
168nucleobase biosynthetic process (GO:0046112)2.88030899
169regulation of mitochondrial translation (GO:0070129)2.87031180
170protein targeting to mitochondrion (GO:0006626)2.84125468
171deoxyribonucleotide biosynthetic process (GO:0009263)2.83093580
172protein complex disassembly (GO:0043241)2.81413024
173guanosine-containing compound biosynthetic process (GO:1901070)2.80980297
174mitotic sister chromatid cohesion (GO:0007064)2.77373989
175DNA duplex unwinding (GO:0032508)2.76878584
176deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76419578
177telomere maintenance via recombination (GO:0000722)2.71971621
178translation (GO:0006412)2.69866925
179GDP-mannose metabolic process (GO:0019673)2.69268390
180rRNA processing (GO:0006364)2.69009296
181macromolecular complex disassembly (GO:0032984)2.68694547
1822-deoxyribonucleotide biosynthetic process (GO:0009265)2.68585344
183deoxyribose phosphate biosynthetic process (GO:0046385)2.68585344
184termination of RNA polymerase II transcription (GO:0006369)2.68289098
185non-recombinational repair (GO:0000726)2.67854089
186double-strand break repair via nonhomologous end joining (GO:0006303)2.67854089
187protein maturation by protein folding (GO:0022417)2.67763959
188protoporphyrinogen IX metabolic process (GO:0046501)2.66736034
189positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.64667347
190regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.64667347
191regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.64235225
192oxidative phosphorylation (GO:0006119)2.64104746
193pentose-phosphate shunt (GO:0006098)2.63622661
194retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.63221124
195spliceosomal snRNP assembly (GO:0000387)2.62749701
196DNA geometric change (GO:0032392)2.62511788
197chromatin remodeling at centromere (GO:0031055)2.61773309
198rRNA transcription (GO:0009303)2.61656334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.72089509
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.87489186
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.32194313
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.52952801
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.29274395
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.86085016
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.55895926
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.53125445
9E2F7_22180533_ChIP-Seq_HELA_Human3.43443705
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.21170817
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.10713374
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64875424
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.45667824
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.41225939
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.41087035
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40420506
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.33234284
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15384376
19AR_21909140_ChIP-Seq_LNCAP_Human2.15326251
20CLOCK_20551151_ChIP-Seq_293T_Human2.09217783
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93159813
22ZNF263_19887448_ChIP-Seq_K562_Human1.89606262
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87707417
24TTF2_22483619_ChIP-Seq_HELA_Human1.86240677
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82543753
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79421822
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74972993
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70270707
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68920696
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68418443
31FOXP3_21729870_ChIP-Seq_TREG_Human1.63443747
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60074246
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59169115
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58274866
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57771947
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56570006
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55822514
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51905602
39* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51669100
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50589779
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50493821
42* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49532072
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48931255
44* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.48570859
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47782313
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.46093523
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44453647
48TFEB_21752829_ChIP-Seq_HELA_Human1.44109263
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42685465
50VDR_23849224_ChIP-Seq_CD4+_Human1.42623915
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41794955
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35905661
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35623549
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35526560
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34230085
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34082576
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33708749
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33288642
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32454327
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30134283
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30009195
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29902916
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29521143
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28279638
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.26674806
66VDR_21846776_ChIP-Seq_THP-1_Human1.25162612
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25002062
68CIITA_25753668_ChIP-Seq_RAJI_Human1.24561953
69XRN2_22483619_ChIP-Seq_HELA_Human1.23878281
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.23868251
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23204817
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21858652
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21093362
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19707767
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15787438
76* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15645998
77KDM5A_27292631_Chip-Seq_BREAST_Human1.15168490
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13524320
79ATF3_27146783_Chip-Seq_COLON_Human1.10864094
80* DCP1A_22483619_ChIP-Seq_HELA_Human1.08743229
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08437366
82GABP_19822575_ChIP-Seq_HepG2_Human1.07701350
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07469949
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.06278459
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04181191
86* GATA6_25053715_ChIP-Seq_YYC3_Human1.03579603
87TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03496658
88* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02691152
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02561472
90ELK1_19687146_ChIP-ChIP_HELA_Human1.01717903
91TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01019090
92GATA4_25053715_ChIP-Seq_YYC3_Human1.00506949
93RACK7_27058665_Chip-Seq_MCF-7_Human0.99321096
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99162629
95CHD1_26751641_Chip-Seq_LNCaP_Human0.99150970
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98601034
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98087039
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97658366
99* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97144395
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.97029202
101MYC_22102868_ChIP-Seq_BL_Human0.96482493
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96390546
103PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95670945
104GABP_17652178_ChIP-ChIP_JURKAT_Human0.95573406
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94541308
106NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94051494
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93280440
108FOXA2_19822575_ChIP-Seq_HepG2_Human0.93204569
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91731545
110TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91564281
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91322524
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91182013
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90149506
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90104585
115NCOR1_26117541_ChIP-Seq_K562_Human0.87990682
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86961790
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86152228
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85782617
119* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85579888
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83717417
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83137947
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82483639
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80099045
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78912214
125EST1_17652178_ChIP-ChIP_JURKAT_Human0.78677687
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78386820
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77227753
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.76379398
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76289203
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76183796
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76148948
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76034478
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75387688
134* RARA_24833708_ChIP-Seq_LIVER_Mouse0.74958328
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74148117
136* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73665586
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73312439
138RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72891122
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72572769
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.71746004
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71576596
142* CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.71112753
143SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70890962
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70756481
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69417944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.68530131
2MP0005360_urolithiasis7.07462274
3MP0005085_abnormal_gallbladder_physiolo5.72051048
4MP0005365_abnormal_bile_salt5.67788183
5MP0003806_abnormal_nucleotide_metabolis4.34107814
6MP0008875_abnormal_xenobiotic_pharmacok4.20947043
7MP0003252_abnormal_bile_duct3.38209034
8MP0008057_abnormal_DNA_replication3.23769355
9MP0010329_abnormal_lipoprotein_level3.09708309
10MP0001666_abnormal_nutrient_absorption2.93487950
11MP0010234_abnormal_vibrissa_follicle2.87830330
12MP0009840_abnormal_foam_cell2.76584670
13MP0005083_abnormal_biliary_tract2.75467109
14MP0008058_abnormal_DNA_repair2.72848259
15MP0008932_abnormal_embryonic_tissue2.71725391
16MP0005332_abnormal_amino_acid2.54165626
17MP0003705_abnormal_hypodermis_morpholog2.46231961
18MP0002877_abnormal_melanocyte_morpholog2.30452288
19MP0008007_abnormal_cellular_replicative2.28156409
20MP0002009_preneoplasia2.13257155
21MP0004147_increased_porphyrin_level2.05984561
22MP0000609_abnormal_liver_physiology2.00500920
23MP0004019_abnormal_vitamin_homeostasis2.00407528
24MP0003868_abnormal_feces_composition1.98174083
25MP0005501_abnormal_skin_physiology1.96315983
26MP0008260_abnormal_autophagy1.88909738
27MP0003786_premature_aging1.88818823
28MP0003195_calcinosis1.88218835
29MP0003941_abnormal_skin_development1.82294233
30MP0004185_abnormal_adipocyte_glucose1.81882920
31MP0002138_abnormal_hepatobiliary_system1.75891891
32MP0000313_abnormal_cell_death1.74331075
33MP0005319_abnormal_enzyme/_coenzyme1.73997915
34MP0010352_gastrointestinal_tract_polyps1.65172582
35MP0002118_abnormal_lipid_homeostasis1.63470424
36MP0000490_abnormal_crypts_of1.60942398
37MP0001346_abnormal_lacrimal_gland1.58534290
38MP0009053_abnormal_anal_canal1.56579301
39MP0004233_abnormal_muscle_weight1.54634320
40MP0003693_abnormal_embryo_hatching1.50934919
41MP0001764_abnormal_homeostasis1.47911144
42MP0002396_abnormal_hematopoietic_system1.43880741
43MP0003191_abnormal_cellular_cholesterol1.40037105
44MP0009697_abnormal_copulation1.34994068
45MP0009643_abnormal_urine_homeostasis1.33359599
46MP0002085_abnormal_embryonic_tissue1.31283691
47MP0000598_abnormal_liver_morphology1.28835382
48MP0004264_abnormal_extraembryonic_tissu1.25383242
49MP0003186_abnormal_redox_activity1.24104791
50MP0001727_abnormal_embryo_implantation1.20274371
51MP0001188_hyperpigmentation1.19527321
52MP0008995_early_reproductive_senescence1.19045888
53MP0005584_abnormal_enzyme/coenzyme_acti1.13796824
54MP0005220_abnormal_exocrine_pancreas1.13465216
55MP0003656_abnormal_erythrocyte_physiolo1.12690378
56MP0000537_abnormal_urethra_morphology1.11988285
57MP0004957_abnormal_blastocyst_morpholog1.11521039
58MP0002019_abnormal_tumor_incidence1.07916060
59MP0004782_abnormal_surfactant_physiolog1.06367070
60MP0005384_cellular_phenotype1.05799752
61MP0005408_hypopigmentation1.05197726
62MP0005621_abnormal_cell_physiology1.01820406
63MP0009703_decreased_birth_body0.99772800
64MP0005647_abnormal_sex_gland0.97602749
65MP0002098_abnormal_vibrissa_morphology0.94467774
66MP0003718_maternal_effect0.94443190
67MP0005636_abnormal_mineral_homeostasis0.93377086
68MP0000627_abnormal_mammary_gland0.92608375
69MP0003890_abnormal_embryonic-extraembry0.92268913
70MP0000678_abnormal_parathyroid_gland0.92037823
71MP0009379_abnormal_foot_pigmentation0.90007916
72MP0004808_abnormal_hematopoietic_stem0.89779627
73MP0000377_abnormal_hair_follicle0.88978910
74MP0001730_embryonic_growth_arrest0.88725635
75MP0009333_abnormal_splenocyte_physiolog0.87079349
76MP0001756_abnormal_urination0.86128767
77MP0005084_abnormal_gallbladder_morpholo0.85984448
78MP0000703_abnormal_thymus_morphology0.85754138
79MP0003453_abnormal_keratinocyte_physiol0.84107735
80MP0009672_abnormal_birth_weight0.83464539
81MP0001216_abnormal_epidermal_layer0.80620986
82MP0000604_amyloidosis0.78935469
83MP0002210_abnormal_sex_determination0.78739737
84MP0006035_abnormal_mitochondrial_morpho0.78363688
85MP0001873_stomach_inflammation0.77988359
86MP0001661_extended_life_span0.77457878
87MP0005451_abnormal_body_composition0.75948875
88MP0001145_abnormal_male_reproductive0.73807253
89MP0009642_abnormal_blood_homeostasis0.72456246
90MP0002160_abnormal_reproductive_system0.71006740
91MP0003111_abnormal_nucleus_morphology0.70969822
92MP0006036_abnormal_mitochondrial_physio0.70755407
93MP0002697_abnormal_eye_size0.70137119
94MP0009765_abnormal_xenobiotic_induced0.69881204
95MP0005187_abnormal_penis_morphology0.69514449
96MP0005376_homeostasis/metabolism_phenot0.69387606
97MP0009931_abnormal_skin_appearance0.69053173
98MP0006054_spinal_hemorrhage0.67360117
99MP0001929_abnormal_gametogenesis0.66840005
100MP0000462_abnormal_digestive_system0.66813152
101MP0002254_reproductive_system_inflammat0.66741130
102MP0005266_abnormal_metabolism0.66724401
103MP0002111_abnormal_tail_morphology0.66548250
104MP0005248_abnormal_Harderian_gland0.65025743
105MP0009763_increased_sensitivity_to0.64788429
106MP0002078_abnormal_glucose_homeostasis0.63991072
107MP0009764_decreased_sensitivity_to0.63840068
108MP0005075_abnormal_melanosome_morpholog0.62243334
109MP0003119_abnormal_digestive_system0.61836294
110MP0003861_abnormal_nervous_system0.61499836
111MP0003077_abnormal_cell_cycle0.60647024
112MP0002086_abnormal_extraembryonic_tissu0.60560264
113MP0001919_abnormal_reproductive_system0.60331695
114MP0005076_abnormal_cell_differentiation0.60083000
115MP0005666_abnormal_adipose_tissue0.59957464
116MP0010771_integument_phenotype0.59950709
117MP0005380_embryogenesis_phenotype0.58991568
118MP0001672_abnormal_embryogenesis/_devel0.58991568
119MP0001853_heart_inflammation0.57987611
120MP0001348_abnormal_lacrimal_gland0.57164369
121MP0004270_analgesia0.56221991
122MP0002136_abnormal_kidney_physiology0.55597335
123MP0003011_delayed_dark_adaptation0.55490694
124MP0002088_abnormal_embryonic_growth/wei0.55451237
125MP0008873_increased_physiological_sensi0.55317644
126MP0002080_prenatal_lethality0.54876082
127MP0004197_abnormal_fetal_growth/weight/0.54644257
128MP0002249_abnormal_larynx_morphology0.54258259
129MP0001697_abnormal_embryo_size0.54157042
130MP0003984_embryonic_growth_retardation0.53909472
131MP0008469_abnormal_protein_level0.53722442
132MP0005395_other_phenotype0.53609114
133MP0001529_abnormal_vocalization0.53607724
134MP0000653_abnormal_sex_gland0.53029608
135MP0001915_intracranial_hemorrhage0.52923201
136MP0001340_abnormal_eyelid_morphology0.52169486
137MP0000358_abnormal_cell_content/0.51839919
138MP0010307_abnormal_tumor_latency0.49742569
139MP0001881_abnormal_mammary_gland0.49316103
140MP0000477_abnormal_intestine_morphology0.48971741
141MP0000350_abnormal_cell_proliferation0.48791817
142MP0002796_impaired_skin_barrier0.48027506
143MP0005023_abnormal_wound_healing0.46729935
144MP0003300_gastrointestinal_ulcer0.46382762
145MP0001849_ear_inflammation0.45535702
146MP0010094_abnormal_chromosome_stability0.45025431
147MP0003567_abnormal_fetal_cardiomyocyte0.42793302
148MP0003221_abnormal_cardiomyocyte_apopto0.42016604
149MP0003638_abnormal_response/metabolism_0.40885776
150MP0005334_abnormal_fat_pad0.40655762
151MP0001944_abnormal_pancreas_morphology0.39400725
152MP0000538_abnormal_urinary_bladder0.39078394
153MP0003123_paternal_imprinting0.39047083
154MP0002084_abnormal_developmental_patter0.38409265
155MP0002928_abnormal_bile_duct0.38403289
156MP0002135_abnormal_kidney_morphology0.37360918
157MP0003699_abnormal_female_reproductive0.36897319
158MP0008872_abnormal_physiological_respon0.36658874

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64550380
2Intrahepatic cholestasis (HP:0001406)6.54406764
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.50108771
4Hypobetalipoproteinemia (HP:0003563)6.41711895
5Deep venous thrombosis (HP:0002625)6.38587711
6Xanthomatosis (HP:0000991)5.67735379
7Prolonged partial thromboplastin time (HP:0003645)5.07840345
8Hypolipoproteinemia (HP:0010981)4.67905715
9Hyperlipoproteinemia (HP:0010980)4.65004705
10Hyperammonemia (HP:0001987)4.35384068
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.25306325
12Complement deficiency (HP:0004431)4.20179540
13Hyperglycinemia (HP:0002154)4.20116184
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.20031787
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13594598
16Abnormality of pyrimidine metabolism (HP:0004353)4.13485352
17Abnormality of the common coagulation pathway (HP:0010990)3.93751841
18Hyperglycinuria (HP:0003108)3.92797595
19Epidermoid cyst (HP:0200040)3.88176709
20Fat malabsorption (HP:0002630)3.85176229
21Ketosis (HP:0001946)3.82788212
22Hypoalphalipoproteinemia (HP:0003233)3.82212527
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.74813548
24Abnormality of glycine metabolism (HP:0010895)3.69449127
25Abnormality of serine family amino acid metabolism (HP:0010894)3.69449127
26Abnormality of methionine metabolism (HP:0010901)3.57990849
27Abnormality of the intrinsic pathway (HP:0010989)3.54031680
28Spastic diplegia (HP:0001264)3.49714326
29Hypoglycemic coma (HP:0001325)3.44677369
30Progressive muscle weakness (HP:0003323)3.43916287
31Microvesicular hepatic steatosis (HP:0001414)3.37494743
32Conjugated hyperbilirubinemia (HP:0002908)3.33361041
33Hepatocellular carcinoma (HP:0001402)3.27686490
34Reticulocytopenia (HP:0001896)3.26024463
35Abnormality of complement system (HP:0005339)3.17746205
36Abnormality of nucleobase metabolism (HP:0010932)3.17640968
37Joint hemorrhage (HP:0005261)3.04030442
38Hyperbilirubinemia (HP:0002904)3.02113028
39Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02029651
40Hypercholesterolemia (HP:0003124)2.99907249
41Progressive external ophthalmoplegia (HP:0000590)2.91506865
42Delayed CNS myelination (HP:0002188)2.89871848
43Abnormality of serum amino acid levels (HP:0003112)2.87429274
44Ketoacidosis (HP:0001993)2.85072472
45Gout (HP:0001997)2.81772631
46Malnutrition (HP:0004395)2.78476426
47Chromsome breakage (HP:0040012)2.77736932
48Steatorrhea (HP:0002570)2.71996925
49Abnormality of cells of the erythroid lineage (HP:0012130)2.70094208
50Abnormality of purine metabolism (HP:0004352)2.69718776
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67341282
52Hypochromic microcytic anemia (HP:0004840)2.66674196
53Asymmetry of the thorax (HP:0001555)2.65638214
54Macrocytic anemia (HP:0001972)2.62487661
55Selective tooth agenesis (HP:0001592)2.62486736
56Esophageal varix (HP:0002040)2.61847554
57Abnormality of fatty-acid metabolism (HP:0004359)2.59663909
58Septate vagina (HP:0001153)2.58348427
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56799969
60Abnormality of reticulocytes (HP:0004312)2.50843533
61Abnormal cartilage morphology (HP:0002763)2.49377218
62Acanthocytosis (HP:0001927)2.48112621
63Cortical dysplasia (HP:0002539)2.42069522
64Abnormality of glycolysis (HP:0004366)2.41076033
65Late onset (HP:0003584)2.38524975
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38413470
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38413470
68Hypoglycemic seizures (HP:0002173)2.35568181
69Spontaneous abortion (HP:0005268)2.35192234
70Back pain (HP:0003418)2.35093681
71Skin nodule (HP:0200036)2.33254453
72Ragged-red muscle fibers (HP:0003200)2.31474917
73Neonatal onset (HP:0003623)2.31075683
74Myocardial infarction (HP:0001658)2.28801692
75Lethargy (HP:0001254)2.26917292
76Metabolic acidosis (HP:0001942)2.24248613
77Pallor (HP:0000980)2.22548332
78Increased hepatocellular lipid droplets (HP:0006565)2.21654851
79Increased intramyocellular lipid droplets (HP:0012240)2.21531915
80Birth length less than 3rd percentile (HP:0003561)2.19736695
81Broad distal phalanx of finger (HP:0009836)2.18005034
82Abnormal number of erythroid precursors (HP:0012131)2.16523919
83Irritability (HP:0000737)2.14638824
84Breast carcinoma (HP:0003002)2.14511913
85Lipid accumulation in hepatocytes (HP:0006561)2.14266931
86Sensorimotor neuropathy (HP:0007141)2.13685242
87Aplastic anemia (HP:0001915)2.12715104
88Abnormality of transition element cation homeostasis (HP:0011030)2.11440520
89Abnormality of the umbilical cord (HP:0010881)2.10214123
90Truncus arteriosus (HP:0001660)2.09471218
91Hydroxyprolinuria (HP:0003080)2.08723684
92Abnormality of proline metabolism (HP:0010907)2.08723684
93Increased nuchal translucency (HP:0010880)2.08520721
94Poikilocytosis (HP:0004447)2.05755805
95Abnormality of the preputium (HP:0100587)2.05098009
96Vascular calcification (HP:0004934)2.03389084
97Increased muscle lipid content (HP:0009058)2.01503701
98Cerebral hypomyelination (HP:0006808)2.00407291
99Insomnia (HP:0100785)1.99594395
100Increased serum pyruvate (HP:0003542)1.99584698
101Cholelithiasis (HP:0001081)1.99529528
102Brushfield spots (HP:0001088)1.99063712
103Pancreatitis (HP:0001733)1.98909961
104Abnormal umbilical cord blood vessels (HP:0011403)1.98658469
105Single umbilical artery (HP:0001195)1.98658469
106Abnormality of the fetal cardiovascular system (HP:0010948)1.98658469
107Abnormality of the Achilles tendon (HP:0005109)1.97927613
108Abnormal gallbladder physiology (HP:0012438)1.95310945
109Cholecystitis (HP:0001082)1.95310945
110Nephroblastoma (Wilms tumor) (HP:0002667)1.94921774
111Sparse lateral eyebrow (HP:0005338)1.94873806
112Abnormal gallbladder morphology (HP:0012437)1.92668750
113Micronodular cirrhosis (HP:0001413)1.91740846
114Hyperglycemia (HP:0003074)1.90643541
115Abnormality of iron homeostasis (HP:0011031)1.90466829
116Medulloblastoma (HP:0002885)1.90124074
117Cutaneous melanoma (HP:0012056)1.90025872
118Oral leukoplakia (HP:0002745)1.89065317
119Rough bone trabeculation (HP:0100670)1.87742642
120Syringomyelia (HP:0003396)1.86086893
121Spinal cord lesions (HP:0100561)1.86086893
122Ileus (HP:0002595)1.85081640
123Abnormal large intestine physiology (HP:0012700)1.84799557
124Curly hair (HP:0002212)1.83967417
125Cerebral edema (HP:0002181)1.83777874
126Facial cleft (HP:0002006)1.83547257
127Upper limb muscle weakness (HP:0003484)1.83414892
128Increased purine levels (HP:0004368)1.83359251
129Hyperuricemia (HP:0002149)1.83359251
130Dicarboxylic aciduria (HP:0003215)1.82962965
131Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82962965
132Hyperinsulinemic hypoglycemia (HP:0000825)1.82738071
133Bowel incontinence (HP:0002607)1.81800665
134Abnormality of the anterior horn cell (HP:0006802)1.81750756
135Degeneration of anterior horn cells (HP:0002398)1.81750756
136Proximal tubulopathy (HP:0000114)1.80914459
137Abnormality of chromosome stability (HP:0003220)1.79805787
138Reticulocytosis (HP:0001923)1.79791241
139Myelodysplasia (HP:0002863)1.79327973
140Long palpebral fissure (HP:0000637)1.79033593
141Cardiovascular calcification (HP:0011915)1.78697018
142Thrombophlebitis (HP:0004418)1.78181993
143Unilateral renal agenesis (HP:0000122)1.77981107
144Deep philtrum (HP:0002002)1.77521896
145Abnormality of the gallbladder (HP:0005264)1.77380813
146Ankyloglossia (HP:0010296)1.76804841
147Abnormality of the lower motor neuron (HP:0002366)1.76347194
148Multiple enchondromatosis (HP:0005701)1.75505521
149Orthostatic hypotension (HP:0001278)1.74714494
150Deep palmar crease (HP:0006191)1.74280242
151Short middle phalanx of the 5th finger (HP:0004220)1.73845795
152Overlapping toe (HP:0001845)1.73600497
153Neoplasm of the pancreas (HP:0002894)1.73558058
154Cafe-au-lait spot (HP:0000957)1.73542943
155Hypoparathyroidism (HP:0000829)1.73102040
156Embryonal renal neoplasm (HP:0011794)1.72873320
157Trismus (HP:0000211)1.72740313
158Clonus (HP:0002169)1.72727901
159Hyperparathyroidism (HP:0000843)1.71955591
160Increased serum lactate (HP:0002151)1.69989379
161Horseshoe kidney (HP:0000085)1.69212741
162Vomiting (HP:0002013)1.68956568
163Confusion (HP:0001289)1.68868601
164Glossoptosis (HP:0000162)1.68320046
165Proximal placement of thumb (HP:0009623)1.68031682
166Dysphonia (HP:0001618)1.67872039
167Rickets (HP:0002748)1.67856613
168Upper motor neuron abnormality (HP:0002127)1.67816122
169Death in infancy (HP:0001522)1.67421443
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.66375081
171Termporal pattern (HP:0011008)1.66108410
172Insidious onset (HP:0003587)1.66108410
173Megaloblastic anemia (HP:0001889)1.66030912
174Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65830986
175Pseudobulbar signs (HP:0002200)1.65478803
176Systemic lupus erythematosus (HP:0002725)1.65422394
177Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.65293170
178Ankle clonus (HP:0011448)1.64863913
179Abnormal enzyme/coenzyme activity (HP:0012379)1.64754375
180Respiratory difficulties (HP:0002880)1.64437229
181Secondary amenorrhea (HP:0000869)1.63223493
182Status epilepticus (HP:0002133)1.63163368
183Death in childhood (HP:0003819)1.63054435
184Malignant gastrointestinal tract tumors (HP:0006749)1.61604449
185Gastrointestinal carcinoma (HP:0002672)1.61604449
186Mitral stenosis (HP:0001718)1.61179845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.27042824
2NME23.62071328
3PKN23.35865274
4TRIB33.13221859
5FRK3.02033467
6PBK2.96279816
7SCYL22.88350266
8ERN12.63851368
9SMG12.37965682
10EPHA22.29873973
11MST1R2.28510237
12MAP3K102.26556903
13PRPF4B2.23829140
14CDK192.19973023
15LATS12.13808613
16ERBB42.05002983
17SIK12.04021780
18NEK11.97562167
19LATS21.80901281
20WEE11.78537911
21BUB11.76767177
22EIF2AK11.76293036
23FGFR41.75318619
24STK161.64409619
25PTK61.55881380
26TESK11.54065758
27ZAK1.46593182
28CDC71.46336448
29KSR21.45005360
30EEF2K1.43767401
31FLT31.41713607
32TESK21.40497051
33MAP3K91.37299055
34NEK21.36056971
35MARK11.33877753
36ACVR1B1.28967728
37RIPK11.27565657
38TTK1.26935374
39MAP3K21.25613224
40VRK21.24709337
41MAPK111.22375958
42MAP3K81.20902156
43MET1.15821272
44KDR1.15820568
45MAP3K111.15706183
46RPS6KB21.15147258
47IRAK31.10818209
48PLK41.05137107
49STK38L1.03055471
50MAP2K21.02859347
51CDK61.01157355
52RPS6KA41.00622171
53IRAK20.99454682
54ARAF0.98987379
55SIK30.97078314
56CDK120.96355866
57MAPKAPK30.94883165
58DYRK30.94662438
59MAP2K40.94259134
60DAPK10.92964904
61DAPK20.92407415
62CHEK10.92113456
63NEK60.91743659
64GRK60.90245909
65AURKA0.87923582
66KSR10.87612725
67BRD40.84749655
68ABL20.84084864
69PRKCI0.82513460
70CDK40.81693994
71FGFR20.81175239
72PTK20.80524203
73ICK0.80414451
74ERBB20.80258792
75PAK40.78989013
76AURKB0.78971268
77ILK0.78446409
78MTOR0.77823808
79TLK10.77157934
80MAP3K120.76303266
81TAOK30.76212420
82PLK10.75027984
83CLK10.74479177
84TGFBR10.73672527
85PDK20.71622957
86RAF10.71318368
87MST40.69611418
88CDK11A0.68926901
89LRRK20.68328214
90CDK140.68299573
91PLK30.68299182
92PDK30.67999899
93PDK40.67999899
94MAP3K50.67713521
95TRIM280.66911090
96BRAF0.66611031
97CAMKK10.65027589
98MAP2K10.64614081
99STK40.63712353
100PIM10.63463224
101MAP3K30.63407137
102DYRK1B0.62543399
103RPS6KB10.62429700
104MAP2K60.60426827
105VRK10.60315002
106CDK180.60176037
107CSNK1G30.60050710
108PRKCZ0.59848033
109CDK150.59641012
110PDGFRA0.59141533
111PASK0.58876375
112PIM20.58103230
113EIF2AK30.57782085
114STK30.57761312
115RET0.57704392
116SRPK10.57539048
117MELK0.57095320
118NME10.56686450
119CHEK20.55764655
120NEK90.55423965
121DYRK20.55041802
122AKT20.54947593
123RPS6KA50.52923938
124BRSK20.52490971
125MINK10.51053267
126ATM0.50758381
127TAOK10.48280929
128AKT30.48125635
129CDK10.48081270
130BRSK10.47065560
131PAK10.46210280
132TAF10.45862382
133FGFR10.44827512
134TAOK20.43520347
135TSSK60.42937915
136BMX0.41336649
137MAP2K70.40149859
138CSNK1E0.40076124
139ATR0.39948967
140CDK70.39547231
141CSNK1A1L0.39446635
142JAK20.39434408
143STK100.39269434
144DAPK30.37215944
145CSNK2A10.37015554
146ALK0.36401106
147MAP2K30.32620460
148CDK20.32578605
149CSNK2A20.31850380
150PRKAA10.31313826

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.10814150
2Nitrogen metabolism_Homo sapiens_hsa009103.57342148
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41007618
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38582921
5Ribosome_Homo sapiens_hsa030103.17987982
6Arginine biosynthesis_Homo sapiens_hsa002203.15340170
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.84218015
8Base excision repair_Homo sapiens_hsa034102.57233124
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57209452
10Tryptophan metabolism_Homo sapiens_hsa003802.48198554
11Selenocompound metabolism_Homo sapiens_hsa004502.25669034
12Fatty acid degradation_Homo sapiens_hsa000712.21549714
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19594807
14Complement and coagulation cascades_Homo sapiens_hsa046102.19574268
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09700918
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09004507
17mRNA surveillance pathway_Homo sapiens_hsa030152.01871784
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99794474
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.97262411
20Non-homologous end-joining_Homo sapiens_hsa034501.92942158
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.90054965
22RNA polymerase_Homo sapiens_hsa030201.83571169
23One carbon pool by folate_Homo sapiens_hsa006701.83489043
24Butanoate metabolism_Homo sapiens_hsa006501.82863997
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77801416
26Peroxisome_Homo sapiens_hsa041461.74502784
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.73218967
28Propanoate metabolism_Homo sapiens_hsa006401.70812590
29Nucleotide excision repair_Homo sapiens_hsa034201.68065908
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67882656
31Biosynthesis of amino acids_Homo sapiens_hsa012301.65946287
32Folate biosynthesis_Homo sapiens_hsa007901.63045217
33PPAR signaling pathway_Homo sapiens_hsa033201.58699416
34Bile secretion_Homo sapiens_hsa049761.58544645
35Fat digestion and absorption_Homo sapiens_hsa049751.57912752
36Caffeine metabolism_Homo sapiens_hsa002321.57795430
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.55777589
38Chemical carcinogenesis_Homo sapiens_hsa052041.55727068
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53773572
40Pyruvate metabolism_Homo sapiens_hsa006201.48542388
41Sulfur metabolism_Homo sapiens_hsa009201.45023538
42Histidine metabolism_Homo sapiens_hsa003401.42782611
43Carbon metabolism_Homo sapiens_hsa012001.40294664
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.36977066
45beta-Alanine metabolism_Homo sapiens_hsa004101.36926901
46Fatty acid metabolism_Homo sapiens_hsa012121.35708612
47Homologous recombination_Homo sapiens_hsa034401.32672762
48Retinol metabolism_Homo sapiens_hsa008301.32230816
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31150458
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31132960
51Phenylalanine metabolism_Homo sapiens_hsa003601.28287220
52Alcoholism_Homo sapiens_hsa050341.27391532
53Sulfur relay system_Homo sapiens_hsa041221.26068820
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.23690579
55Chronic myeloid leukemia_Homo sapiens_hsa052201.23399541
56Starch and sucrose metabolism_Homo sapiens_hsa005001.17969214
57Vibrio cholerae infection_Homo sapiens_hsa051101.17852498
58Tyrosine metabolism_Homo sapiens_hsa003501.16042828
59Synaptic vesicle cycle_Homo sapiens_hsa047211.09794726
60Viral carcinogenesis_Homo sapiens_hsa052031.06333211
61Non-small cell lung cancer_Homo sapiens_hsa052231.02872945
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99075112
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98876622
64Staphylococcus aureus infection_Homo sapiens_hsa051500.97458148
65Acute myeloid leukemia_Homo sapiens_hsa052210.96554836
66Purine metabolism_Homo sapiens_hsa002300.96375640
67Arginine and proline metabolism_Homo sapiens_hsa003300.95409893
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90855844
69Vitamin digestion and absorption_Homo sapiens_hsa049770.90664119
70Fanconi anemia pathway_Homo sapiens_hsa034600.89393644
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88519158
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87296649
73Glutathione metabolism_Homo sapiens_hsa004800.86608652
74Pancreatic cancer_Homo sapiens_hsa052120.86098418
75Pentose phosphate pathway_Homo sapiens_hsa000300.85526287
76Oocyte meiosis_Homo sapiens_hsa041140.82844819
77RNA degradation_Homo sapiens_hsa030180.82745537
78Vitamin B6 metabolism_Homo sapiens_hsa007500.81159548
79Steroid biosynthesis_Homo sapiens_hsa001000.79748476
80Colorectal cancer_Homo sapiens_hsa052100.79458281
81Oxidative phosphorylation_Homo sapiens_hsa001900.78988510
82Epstein-Barr virus infection_Homo sapiens_hsa051690.77807641
83Lysine degradation_Homo sapiens_hsa003100.77359244
84Parkinsons disease_Homo sapiens_hsa050120.73988779
85Shigellosis_Homo sapiens_hsa051310.73173740
86ABC transporters_Homo sapiens_hsa020100.72836417
87Huntingtons disease_Homo sapiens_hsa050160.72001871
88Renal cell carcinoma_Homo sapiens_hsa052110.68103663
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66920204
90ErbB signaling pathway_Homo sapiens_hsa040120.66456015
91Basal transcription factors_Homo sapiens_hsa030220.65266119
92Glioma_Homo sapiens_hsa052140.64955066
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63504914
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63179227
95Glycerolipid metabolism_Homo sapiens_hsa005610.63043289
96Fructose and mannose metabolism_Homo sapiens_hsa000510.61586663
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58444754
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57676999
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57402039
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54182125
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52328172
102VEGF signaling pathway_Homo sapiens_hsa043700.51283243
103Hepatitis B_Homo sapiens_hsa051610.51107394
104Prostate cancer_Homo sapiens_hsa052150.50447625
105Inositol phosphate metabolism_Homo sapiens_hsa005620.47607028
106Collecting duct acid secretion_Homo sapiens_hsa049660.46190811
107Galactose metabolism_Homo sapiens_hsa000520.45075219
108Protein export_Homo sapiens_hsa030600.44984322
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43833728
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43687866
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43252701
112Metabolic pathways_Homo sapiens_hsa011000.43233173
113Proteasome_Homo sapiens_hsa030500.42805930
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40425579
115HIF-1 signaling pathway_Homo sapiens_hsa040660.39698341
116RNA transport_Homo sapiens_hsa030130.39206818
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39082487
118Apoptosis_Homo sapiens_hsa042100.38771610
119Prion diseases_Homo sapiens_hsa050200.38400317
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37921395
121Systemic lupus erythematosus_Homo sapiens_hsa053220.35322611
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35155783
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.35132196
124Pyrimidine metabolism_Homo sapiens_hsa002400.34994700
125DNA replication_Homo sapiens_hsa030300.34041583
126Bladder cancer_Homo sapiens_hsa052190.32361937
127MicroRNAs in cancer_Homo sapiens_hsa052060.32238611
128Fatty acid biosynthesis_Homo sapiens_hsa000610.31850992
129Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24752596
130Insulin resistance_Homo sapiens_hsa049310.24515883
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.23449387
132Thyroid cancer_Homo sapiens_hsa052160.21676419
133Mismatch repair_Homo sapiens_hsa034300.21541885
134Renin-angiotensin system_Homo sapiens_hsa046140.20618131
135Fatty acid elongation_Homo sapiens_hsa000620.20445196
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19453960
137AMPK signaling pathway_Homo sapiens_hsa041520.14882347
138Glucagon signaling pathway_Homo sapiens_hsa049220.12739720
139N-Glycan biosynthesis_Homo sapiens_hsa005100.12237350
140Cell cycle_Homo sapiens_hsa041100.04930991
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.04082007
142Insulin signaling pathway_Homo sapiens_hsa049100.02318350
143p53 signaling pathway_Homo sapiens_hsa041150.02277345
144Endometrial cancer_Homo sapiens_hsa052130.01178241
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.00984288
146Spliceosome_Homo sapiens_hsa030400.00808090
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.00302546
148mTOR signaling pathway_Homo sapiens_hsa04150-0.0311005
149Ubiquitin mediated proteolysis_Homo sapiens_hsa04120-0.0209185
150Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0142193

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