ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.41714823
2	L-phenylalanine catabolic process (GO:0006559)	6.41714823
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.40394490
4	L-phenylalanine metabolic process (GO:0006558)	6.40394490
5	aromatic amino acid family catabolic process (GO:0009074)	5.74320660
6	cysteine metabolic process (GO:0006534)	5.59770714
7	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.50452664
8	urea metabolic process (GO:0019627)	5.33775294
9	urea cycle (GO:0000050)	5.33775294
10	kynurenine metabolic process (GO:0070189)	5.21076557
11	indolalkylamine catabolic process (GO:0046218)	5.12166975
12	tryptophan catabolic process (GO:0006569)	5.12166975
13	indole-containing compound catabolic process (GO:0042436)	5.12166975
14	glyoxylate metabolic process (GO:0046487)	5.11519488
15	glycine metabolic process (GO:0006544)	5.10416188
16	sulfur amino acid catabolic process (GO:0000098)	5.04325939
17	nuclear pore complex assembly (GO:0051292)	5.03475895
18	serine family amino acid catabolic process (GO:0009071)	5.02971573
19	homocysteine metabolic process (GO:0050667)	4.99661454
20	bile acid biosynthetic process (GO:0006699)	4.99147765
21	negative regulation of fibrinolysis (GO:0051918)	4.98170116
22	alpha-linolenic acid metabolic process (GO:0036109)	4.95239412
23	tryptophan metabolic process (GO:0006568)	4.93092711
24	high-density lipoprotein particle remodeling (GO:0034375)	4.82433490
25	nitrogen cycle metabolic process (GO:0071941)	4.80962342
26	lysine catabolic process (GO:0006554)	4.76207346
27	lysine metabolic process (GO:0006553)	4.76207346
28	DNA unwinding involved in DNA replication (GO:0006268)	4.75185736
29	formation of translation preinitiation complex (GO:0001731)	4.71056208
30	serine family amino acid biosynthetic process (GO:0009070)	4.64029949
31	serine family amino acid metabolic process (GO:0009069)	4.58008475
32	regulation of fibrinolysis (GO:0051917)	4.54951492
33	negative regulation of sterol transport (GO:0032372)	4.54421451
34	negative regulation of cholesterol transport (GO:0032375)	4.54421451
35	nuclear pore organization (GO:0006999)	4.54271264
36	regulation of protein activation cascade (GO:2000257)	4.50193985
37	protein carboxylation (GO:0018214)	4.37520226
38	peptidyl-glutamic acid carboxylation (GO:0017187)	4.37520226
39	aromatic amino acid family metabolic process (GO:0009072)	4.35416542
40	bile acid metabolic process (GO:0008206)	4.33249926
41	bile acid and bile salt transport (GO:0015721)	4.30346896
42	complement activation, alternative pathway (GO:0006957)	4.29341649
43	reverse cholesterol transport (GO:0043691)	4.20874124
44	regulation of complement activation (GO:0030449)	4.20041427
45	alpha-amino acid catabolic process (GO:1901606)	4.18370378
46	tyrosine metabolic process (GO:0006570)	4.17228675
47	imidazole-containing compound metabolic process (GO:0052803)	4.16231399
48	ribosomal small subunit biogenesis (GO:0042274)	4.12921467
49	ribosomal small subunit assembly (GO:0000028)	4.10032722
50	one-carbon metabolic process (GO:0006730)	4.05485966
51	regulation of triglyceride catabolic process (GO:0010896)	4.04126938
52	protein-lipid complex remodeling (GO:0034368)	4.04083310
53	macromolecular complex remodeling (GO:0034367)	4.04083310
54	plasma lipoprotein particle remodeling (GO:0034369)	4.04083310
55	nucleobase-containing small molecule interconversion (GO:0015949)	4.02157235
56	protein complex localization (GO:0031503)	4.00326836
57	amino-acid betaine metabolic process (GO:0006577)	3.98630911
58	triglyceride homeostasis (GO:0070328)	3.97687694
59	acylglycerol homeostasis (GO:0055090)	3.97687694
60	cellular modified amino acid catabolic process (GO:0042219)	3.96040157
61	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.95821806
62	regulation of translational fidelity (GO:0006450)	3.94972422
63	DNA strand elongation involved in DNA replication (GO:0006271)	3.93946438
64	cellular ketone body metabolic process (GO:0046950)	3.91933806
65	peptidyl-arginine omega-N-methylation (GO:0035247)	3.91245746
66	glutamate metabolic process (GO:0006536)	3.89576294
67	cellular amino acid catabolic process (GO:0009063)	3.88780770
68	DNA strand elongation (GO:0022616)	3.88440451
69	regulation of cholesterol esterification (GO:0010872)	3.85687983
70	establishment of integrated proviral latency (GO:0075713)	3.85005991
71	COPI coating of Golgi vesicle (GO:0048205)	3.84107738
72	Golgi transport vesicle coating (GO:0048200)	3.84107738
73	folic acid metabolic process (GO:0046655)	3.78066696
74	pore complex assembly (GO:0046931)	3.77861065
75	folic acid-containing compound biosynthetic process (GO:0009396)	3.74659692
76	drug catabolic process (GO:0042737)	3.71205437
77	ethanol oxidation (GO:0006069)	3.69739467
78	histone arginine methylation (GO:0034969)	3.66885443
79	cellular glucuronidation (GO:0052695)	3.65937026
80	phospholipid efflux (GO:0033700)	3.65565908
81	arginine metabolic process (GO:0006525)	3.63859395
82	intestinal cholesterol absorption (GO:0030299)	3.63247722
83	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.63124611
84	viral transcription (GO:0019083)	3.61913303
85	tetrahydrofolate metabolic process (GO:0046653)	3.61637877
86	plasma lipoprotein particle clearance (GO:0034381)	3.61022462
87	proline biosynthetic process (GO:0006561)	3.60992573
88	regulation of cholesterol homeostasis (GO:2000188)	3.60327425
89	indolalkylamine metabolic process (GO:0006586)	3.59362248
90	maturation of SSU-rRNA (GO:0030490)	3.56991911
91	benzene-containing compound metabolic process (GO:0042537)	3.54261001
92	mitotic chromosome condensation (GO:0007076)	3.54103682
93	ribosomal large subunit biogenesis (GO:0042273)	3.53539207
94	dicarboxylic acid biosynthetic process (GO:0043650)	3.52177932
95	DNA replication initiation (GO:0006270)	3.51176475
96	translational termination (GO:0006415)	3.49645717
97	plasma lipoprotein particle assembly (GO:0034377)	3.48932656
98	ribosome assembly (GO:0042255)	3.48221215
99	cellular protein complex localization (GO:0034629)	3.46303510
100	aldehyde catabolic process (GO:0046185)	3.45806260
101	coenzyme catabolic process (GO:0009109)	3.45465705
102	ketone body metabolic process (GO:1902224)	3.44532473
103	urate metabolic process (GO:0046415)	3.42562932
104	L-serine metabolic process (GO:0006563)	3.41895441
105	ribonucleoprotein complex biogenesis (GO:0022613)	3.40831009
106	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.40549818
107	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.39453493
108	cholesterol efflux (GO:0033344)	3.37544162
109	response to nitrosative stress (GO:0051409)	3.37249086
110	amine catabolic process (GO:0009310)	3.32028042
111	cellular biogenic amine catabolic process (GO:0042402)	3.32028042
112	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.30428085
113	acetyl-CoA metabolic process (GO:0006084)	3.30212648
114	telomere maintenance via semi-conservative replication (GO:0032201)	3.30049171
115	drug transmembrane transport (GO:0006855)	3.28647162
116	pyrimidine nucleobase catabolic process (GO:0006208)	3.28061635
117	translational initiation (GO:0006413)	3.25931843
118	lipoprotein metabolic process (GO:0042157)	3.24980875
119	purine nucleobase biosynthetic process (GO:0009113)	3.23321028
120	cholesterol homeostasis (GO:0042632)	3.23017707
121	regulation of bile acid biosynthetic process (GO:0070857)	3.22797437
122	ribosome biogenesis (GO:0042254)	3.22542269
123	mitotic sister chromatid segregation (GO:0000070)	3.22500557
124	peptidyl-arginine N-methylation (GO:0035246)	3.21654367
125	peptidyl-arginine methylation (GO:0018216)	3.21654367
126	IMP biosynthetic process (GO:0006188)	3.21580084
127	uronic acid metabolic process (GO:0006063)	3.21540748
128	glucuronate metabolic process (GO:0019585)	3.21540748
129	sterol homeostasis (GO:0055092)	3.21419687
130	organic acid catabolic process (GO:0016054)	3.21086107
131	carboxylic acid catabolic process (GO:0046395)	3.21086107
132	fibrinolysis (GO:0042730)	3.20335517
133	2-oxoglutarate metabolic process (GO:0006103)	3.19836238
134	translational elongation (GO:0006414)	3.19821807
135	heme transport (GO:0015886)	3.19332014
136	very-low-density lipoprotein particle assembly (GO:0034379)	3.18698519
137	negative regulation of RNA splicing (GO:0033119)	3.18564837
138	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.18286434
139	aspartate family amino acid catabolic process (GO:0009068)	3.18279607
140	negative regulation of mRNA processing (GO:0050686)	3.17685482
141	intestinal absorption (GO:0050892)	3.17437425
142	positive regulation of lipoprotein lipase activity (GO:0051006)	3.15849199
143	mitotic metaphase plate congression (GO:0007080)	3.15474757
144	protein localization to chromosome, centromeric region (GO:0071459)	3.14035769
145	establishment of viral latency (GO:0019043)	3.13245009
146	cotranslational protein targeting to membrane (GO:0006613)	3.11368002
147	protein targeting to ER (GO:0045047)	3.09707406
148	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.08681859
149	tRNA aminoacylation for protein translation (GO:0006418)	3.07926675
150	negative regulation of mRNA metabolic process (GO:1903312)	3.06757733
151	mitotic nuclear envelope disassembly (GO:0007077)	3.06202858
152	viral life cycle (GO:0019058)	3.05095644
153	protein export from nucleus (GO:0006611)	3.04929027
154	amino acid activation (GO:0043038)	3.00074845
155	tRNA aminoacylation (GO:0043039)	3.00074845
156	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.99544592
157	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.98793206
158	viral mRNA export from host cell nucleus (GO:0046784)	2.97987225
159	regulation of translational termination (GO:0006449)	2.97481327
160	sister chromatid segregation (GO:0000819)	2.96136482
161	protein localization to endoplasmic reticulum (GO:0070972)	2.93358884
162	DNA topological change (GO:0006265)	2.92306929
163	nuclear envelope disassembly (GO:0051081)	2.90641145
164	membrane disassembly (GO:0030397)	2.90641145
165	cellular protein complex disassembly (GO:0043624)	2.90521050
166	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	2.90082613
167	IMP metabolic process (GO:0046040)	2.89756680
168	nucleobase biosynthetic process (GO:0046112)	2.88030899
169	regulation of mitochondrial translation (GO:0070129)	2.87031180
170	protein targeting to mitochondrion (GO:0006626)	2.84125468
171	deoxyribonucleotide biosynthetic process (GO:0009263)	2.83093580
172	protein complex disassembly (GO:0043241)	2.81413024
173	guanosine-containing compound biosynthetic process (GO:1901070)	2.80980297
174	mitotic sister chromatid cohesion (GO:0007064)	2.77373989
175	DNA duplex unwinding (GO:0032508)	2.76878584
176	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.76419578
177	telomere maintenance via recombination (GO:0000722)	2.71971621
178	translation (GO:0006412)	2.69866925
179	GDP-mannose metabolic process (GO:0019673)	2.69268390
180	rRNA processing (GO:0006364)	2.69009296
181	macromolecular complex disassembly (GO:0032984)	2.68694547
182	deoxyribose phosphate biosynthetic process (GO:0046385)	2.68585344
183	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.68585344
184	termination of RNA polymerase II transcription (GO:0006369)	2.68289098
185	double-strand break repair via nonhomologous end joining (GO:0006303)	2.67854089
186	non-recombinational repair (GO:0000726)	2.67854089
187	protein maturation by protein folding (GO:0022417)	2.67763959
188	protoporphyrinogen IX metabolic process (GO:0046501)	2.66736034
189	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	2.64667347
190	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling	2.64667347
191	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.64235225
192	oxidative phosphorylation (GO:0006119)	2.64104746
193	pentose-phosphate shunt (GO:0006098)	2.63622661
194	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.63221124
195	spliceosomal snRNP assembly (GO:0000387)	2.62749701
196	DNA geometric change (GO:0032392)	2.62511788
197	chromatin remodeling at centromere (GO:0031055)	2.61773309
198	rRNA transcription (GO:0009303)	2.61656334

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	8.72089509
2	* RXR_22158963_ChIP-Seq_LIVER_Mouse	5.87489186
3	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.32194313
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.52952801
5	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.29274395
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.86085016
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.55895926
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.53125445
9	E2F7_22180533_ChIP-Seq_HELA_Human	3.43443705
10	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.21170817
11	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.10713374
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.64875424
13	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.45667824
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.41225939
15	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.41087035
16	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.40420506
17	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.33234284
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.15384376
19	AR_21909140_ChIP-Seq_LNCAP_Human	2.15326251
20	CLOCK_20551151_ChIP-Seq_293T_Human	2.09217783
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.93159813
22	ZNF263_19887448_ChIP-Seq_K562_Human	1.89606262
23	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.87707417
24	TTF2_22483619_ChIP-Seq_HELA_Human	1.86240677
25	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.82543753
26	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.79421822
27	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.74972993
28	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.70270707
29	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.68920696
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.68418443
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.63443747
32	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.60074246
33	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.59169115
34	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.58274866
35	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.57771947
36	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.56570006
37	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.55822514
38	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.51905602
39	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.51669100
40	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.50589779
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.50493821
42	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.49532072
43	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.48931255
44	* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.48570859
45	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.47782313
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.46093523
47	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.44453647
48	TFEB_21752829_ChIP-Seq_HELA_Human	1.44109263
49	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.42685465
50	VDR_23849224_ChIP-Seq_CD4+_Human	1.42623915
51	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.41794955
52	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.35905661
53	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.35623549
54	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.35526560
55	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34230085
56	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34082576
57	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.33708749
58	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.33288642
59	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.32454327
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30134283
61	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.30009195
62	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.29902916
63	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.29521143
64	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.28279638
65	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.26674806
66	VDR_21846776_ChIP-Seq_THP-1_Human	1.25162612
67	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.25002062
68	CIITA_25753668_ChIP-Seq_RAJI_Human	1.24561953
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.23878281
70	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.23868251
71	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.23204817
72	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21858652
73	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.21093362
74	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.19707767
75	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.15787438
76	* ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.15645998
77	KDM5A_27292631_Chip-Seq_BREAST_Human	1.15168490
78	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.13524320
79	ATF3_27146783_Chip-Seq_COLON_Human	1.10864094
80	* DCP1A_22483619_ChIP-Seq_HELA_Human	1.08743229
81	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.08437366
82	GABP_19822575_ChIP-Seq_HepG2_Human	1.07701350
83	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.07469949
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.06278459
85	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.04181191
86	* GATA6_25053715_ChIP-Seq_YYC3_Human	1.03579603
87	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.03496658
88	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.02691152
89	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.02561472
90	ELK1_19687146_ChIP-ChIP_HELA_Human	1.01717903
91	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.01019090
92	GATA4_25053715_ChIP-Seq_YYC3_Human	1.00506949
93	RACK7_27058665_Chip-Seq_MCF-7_Human	0.99321096
94	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.99162629
95	CHD1_26751641_Chip-Seq_LNCaP_Human	0.99150970
96	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.98601034
97	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.98087039
98	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.97658366
99	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.97144395
100	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.97029202
101	MYC_22102868_ChIP-Seq_BL_Human	0.96482493
102	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.96390546
103	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.95670945
104	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.95573406
105	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94541308
106	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.94051494
107	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.93280440
108	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.93204569
109	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.91731545
110	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.91564281
111	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.91322524
112	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.91182013
113	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.90149506
114	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.90104585
115	NCOR1_26117541_ChIP-Seq_K562_Human	0.87990682
116	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86961790
117	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.86152228
118	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.85782617
119	* RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.85579888
120	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.83717417
121	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.83137947
122	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.82483639
123	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.80099045
124	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.78912214
125	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.78677687
126	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.78386820
127	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.77227753
128	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.76379398
129	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.76289203
130	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.76183796
131	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.76148948
132	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.76034478
133	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.75387688
134	* RARA_24833708_ChIP-Seq_LIVER_Mouse	0.74958328
135	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.74148117
136	* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.73665586
137	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.73312439
138	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.72891122
139	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.72572769
140	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.71746004
141	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.71576596
142	* CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.71112753
143	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.70890962
144	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.70756481
145	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.69417944

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.68530131
2	MP0005360_urolithiasis	7.07462274
3	MP0005085_abnormal_gallbladder_physiolo	5.72051048
4	MP0005365_abnormal_bile_salt	5.67788183
5	MP0003806_abnormal_nucleotide_metabolis	4.34107814
6	MP0008875_abnormal_xenobiotic_pharmacok	4.20947043
7	MP0003252_abnormal_bile_duct	3.38209034
8	MP0008057_abnormal_DNA_replication	3.23769355
9	MP0010329_abnormal_lipoprotein_level	3.09708309
10	MP0001666_abnormal_nutrient_absorption	2.93487950
11	MP0010234_abnormal_vibrissa_follicle	2.87830330
12	MP0009840_abnormal_foam_cell	2.76584670
13	MP0005083_abnormal_biliary_tract	2.75467109
14	MP0008058_abnormal_DNA_repair	2.72848259
15	MP0008932_abnormal_embryonic_tissue	2.71725391
16	MP0005332_abnormal_amino_acid	2.54165626
17	MP0003705_abnormal_hypodermis_morpholog	2.46231961
18	MP0002877_abnormal_melanocyte_morpholog	2.30452288
19	MP0008007_abnormal_cellular_replicative	2.28156409
20	MP0002009_preneoplasia	2.13257155
21	MP0004147_increased_porphyrin_level	2.05984561
22	MP0000609_abnormal_liver_physiology	2.00500920
23	MP0004019_abnormal_vitamin_homeostasis	2.00407528
24	MP0003868_abnormal_feces_composition	1.98174083
25	MP0005501_abnormal_skin_physiology	1.96315983
26	MP0008260_abnormal_autophagy	1.88909738
27	MP0003786_premature_aging	1.88818823
28	MP0003195_calcinosis	1.88218835
29	MP0003941_abnormal_skin_development	1.82294233
30	MP0004185_abnormal_adipocyte_glucose	1.81882920
31	MP0002138_abnormal_hepatobiliary_system	1.75891891
32	MP0000313_abnormal_cell_death	1.74331075
33	MP0005319_abnormal_enzyme/_coenzyme	1.73997915
34	MP0010352_gastrointestinal_tract_polyps	1.65172582
35	MP0002118_abnormal_lipid_homeostasis	1.63470424
36	MP0000490_abnormal_crypts_of	1.60942398
37	MP0001346_abnormal_lacrimal_gland	1.58534290
38	MP0009053_abnormal_anal_canal	1.56579301
39	MP0004233_abnormal_muscle_weight	1.54634320
40	MP0003693_abnormal_embryo_hatching	1.50934919
41	MP0001764_abnormal_homeostasis	1.47911144
42	MP0002396_abnormal_hematopoietic_system	1.43880741
43	MP0003191_abnormal_cellular_cholesterol	1.40037105
44	MP0009697_abnormal_copulation	1.34994068
45	MP0009643_abnormal_urine_homeostasis	1.33359599
46	MP0002085_abnormal_embryonic_tissue	1.31283691
47	MP0000598_abnormal_liver_morphology	1.28835382
48	MP0004264_abnormal_extraembryonic_tissu	1.25383242
49	MP0003186_abnormal_redox_activity	1.24104791
50	MP0001727_abnormal_embryo_implantation	1.20274371
51	MP0001188_hyperpigmentation	1.19527321
52	MP0008995_early_reproductive_senescence	1.19045888
53	MP0005584_abnormal_enzyme/coenzyme_acti	1.13796824
54	MP0005220_abnormal_exocrine_pancreas	1.13465216
55	MP0003656_abnormal_erythrocyte_physiolo	1.12690378
56	MP0000537_abnormal_urethra_morphology	1.11988285
57	MP0004957_abnormal_blastocyst_morpholog	1.11521039
58	MP0002019_abnormal_tumor_incidence	1.07916060
59	MP0004782_abnormal_surfactant_physiolog	1.06367070
60	MP0005384_cellular_phenotype	1.05799752
61	MP0005408_hypopigmentation	1.05197726
62	MP0005621_abnormal_cell_physiology	1.01820406
63	MP0009703_decreased_birth_body	0.99772800
64	MP0005647_abnormal_sex_gland	0.97602749
65	MP0002098_abnormal_vibrissa_morphology	0.94467774
66	MP0003718_maternal_effect	0.94443190
67	MP0005636_abnormal_mineral_homeostasis	0.93377086
68	MP0000627_abnormal_mammary_gland	0.92608375
69	MP0003890_abnormal_embryonic-extraembry	0.92268913
70	MP0000678_abnormal_parathyroid_gland	0.92037823
71	MP0009379_abnormal_foot_pigmentation	0.90007916
72	MP0004808_abnormal_hematopoietic_stem	0.89779627
73	MP0000377_abnormal_hair_follicle	0.88978910
74	MP0001730_embryonic_growth_arrest	0.88725635
75	MP0009333_abnormal_splenocyte_physiolog	0.87079349
76	MP0001756_abnormal_urination	0.86128767
77	MP0005084_abnormal_gallbladder_morpholo	0.85984448
78	MP0000703_abnormal_thymus_morphology	0.85754138
79	MP0003453_abnormal_keratinocyte_physiol	0.84107735
80	MP0009672_abnormal_birth_weight	0.83464539
81	MP0001216_abnormal_epidermal_layer	0.80620986
82	MP0000604_amyloidosis	0.78935469
83	MP0002210_abnormal_sex_determination	0.78739737
84	MP0006035_abnormal_mitochondrial_morpho	0.78363688
85	MP0001873_stomach_inflammation	0.77988359
86	MP0001661_extended_life_span	0.77457878
87	MP0005451_abnormal_body_composition	0.75948875
88	MP0001145_abnormal_male_reproductive	0.73807253
89	MP0009642_abnormal_blood_homeostasis	0.72456246
90	MP0002160_abnormal_reproductive_system	0.71006740
91	MP0003111_abnormal_nucleus_morphology	0.70969822
92	MP0006036_abnormal_mitochondrial_physio	0.70755407
93	MP0002697_abnormal_eye_size	0.70137119
94	MP0009765_abnormal_xenobiotic_induced	0.69881204
95	MP0005187_abnormal_penis_morphology	0.69514449
96	MP0005376_homeostasis/metabolism_phenot	0.69387606
97	MP0009931_abnormal_skin_appearance	0.69053173
98	MP0006054_spinal_hemorrhage	0.67360117
99	MP0001929_abnormal_gametogenesis	0.66840005
100	MP0000462_abnormal_digestive_system	0.66813152
101	MP0002254_reproductive_system_inflammat	0.66741130
102	MP0005266_abnormal_metabolism	0.66724401
103	MP0002111_abnormal_tail_morphology	0.66548250
104	MP0005248_abnormal_Harderian_gland	0.65025743
105	MP0009763_increased_sensitivity_to	0.64788429
106	MP0002078_abnormal_glucose_homeostasis	0.63991072
107	MP0009764_decreased_sensitivity_to	0.63840068
108	MP0005075_abnormal_melanosome_morpholog	0.62243334
109	MP0003119_abnormal_digestive_system	0.61836294
110	MP0003861_abnormal_nervous_system	0.61499836
111	MP0003077_abnormal_cell_cycle	0.60647024
112	MP0002086_abnormal_extraembryonic_tissu	0.60560264
113	MP0001919_abnormal_reproductive_system	0.60331695
114	MP0005076_abnormal_cell_differentiation	0.60083000
115	MP0005666_abnormal_adipose_tissue	0.59957464
116	MP0010771_integument_phenotype	0.59950709
117	MP0005380_embryogenesis_phenotype	0.58991568
118	MP0001672_abnormal_embryogenesis/_devel	0.58991568
119	MP0001853_heart_inflammation	0.57987611
120	MP0001348_abnormal_lacrimal_gland	0.57164369
121	MP0004270_analgesia	0.56221991
122	MP0002136_abnormal_kidney_physiology	0.55597335
123	MP0003011_delayed_dark_adaptation	0.55490694
124	MP0002088_abnormal_embryonic_growth/wei	0.55451237
125	MP0008873_increased_physiological_sensi	0.55317644
126	MP0002080_prenatal_lethality	0.54876082
127	MP0004197_abnormal_fetal_growth/weight/	0.54644257
128	MP0002249_abnormal_larynx_morphology	0.54258259
129	MP0001697_abnormal_embryo_size	0.54157042
130	MP0003984_embryonic_growth_retardation	0.53909472
131	MP0008469_abnormal_protein_level	0.53722442
132	MP0005395_other_phenotype	0.53609114
133	MP0001529_abnormal_vocalization	0.53607724
134	MP0000653_abnormal_sex_gland	0.53029608
135	MP0001915_intracranial_hemorrhage	0.52923201
136	MP0001340_abnormal_eyelid_morphology	0.52169486
137	MP0000358_abnormal_cell_content/	0.51839919
138	MP0010307_abnormal_tumor_latency	0.49742569
139	MP0001881_abnormal_mammary_gland	0.49316103
140	MP0000477_abnormal_intestine_morphology	0.48971741
141	MP0000350_abnormal_cell_proliferation	0.48791817
142	MP0002796_impaired_skin_barrier	0.48027506
143	MP0005023_abnormal_wound_healing	0.46729935
144	MP0003300_gastrointestinal_ulcer	0.46382762
145	MP0001849_ear_inflammation	0.45535702
146	MP0010094_abnormal_chromosome_stability	0.45025431
147	MP0003567_abnormal_fetal_cardiomyocyte	0.42793302
148	MP0003221_abnormal_cardiomyocyte_apopto	0.42016604
149	MP0003638_abnormal_response/metabolism_	0.40885776
150	MP0005334_abnormal_fat_pad	0.40655762
151	MP0001944_abnormal_pancreas_morphology	0.39400725
152	MP0000538_abnormal_urinary_bladder	0.39078394
153	MP0003123_paternal_imprinting	0.39047083
154	MP0002084_abnormal_developmental_patter	0.38409265
155	MP0002928_abnormal_bile_duct	0.38403289
156	MP0002135_abnormal_kidney_morphology	0.37360918
157	MP0003699_abnormal_female_reproductive	0.36897319
158	MP0008872_abnormal_physiological_respon	0.36658874

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.64550380
2	Intrahepatic cholestasis (HP:0001406)	6.54406764
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.50108771
4	Hypobetalipoproteinemia (HP:0003563)	6.41711895
5	Deep venous thrombosis (HP:0002625)	6.38587711
6	Xanthomatosis (HP:0000991)	5.67735379
7	Prolonged partial thromboplastin time (HP:0003645)	5.07840345
8	Hypolipoproteinemia (HP:0010981)	4.67905715
9	Hyperlipoproteinemia (HP:0010980)	4.65004705
10	Hyperammonemia (HP:0001987)	4.35384068
11	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.25306325
12	Complement deficiency (HP:0004431)	4.20179540
13	Hyperglycinemia (HP:0002154)	4.20116184
14	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.20031787
15	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.13594598
16	Abnormality of pyrimidine metabolism (HP:0004353)	4.13485352
17	Abnormality of the common coagulation pathway (HP:0010990)	3.93751841
18	Hyperglycinuria (HP:0003108)	3.92797595
19	Epidermoid cyst (HP:0200040)	3.88176709
20	Fat malabsorption (HP:0002630)	3.85176229
21	Ketosis (HP:0001946)	3.82788212
22	Hypoalphalipoproteinemia (HP:0003233)	3.82212527
23	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.74813548
24	Abnormality of serine family amino acid metabolism (HP:0010894)	3.69449127
25	Abnormality of glycine metabolism (HP:0010895)	3.69449127
26	Abnormality of methionine metabolism (HP:0010901)	3.57990849
27	Abnormality of the intrinsic pathway (HP:0010989)	3.54031680
28	Spastic diplegia (HP:0001264)	3.49714326
29	Hypoglycemic coma (HP:0001325)	3.44677369
30	Progressive muscle weakness (HP:0003323)	3.43916287
31	Microvesicular hepatic steatosis (HP:0001414)	3.37494743
32	Conjugated hyperbilirubinemia (HP:0002908)	3.33361041
33	Hepatocellular carcinoma (HP:0001402)	3.27686490
34	Reticulocytopenia (HP:0001896)	3.26024463
35	Abnormality of complement system (HP:0005339)	3.17746205
36	Abnormality of nucleobase metabolism (HP:0010932)	3.17640968
37	Joint hemorrhage (HP:0005261)	3.04030442
38	Hyperbilirubinemia (HP:0002904)	3.02113028
39	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.02029651
40	Hypercholesterolemia (HP:0003124)	2.99907249
41	Progressive external ophthalmoplegia (HP:0000590)	2.91506865
42	Delayed CNS myelination (HP:0002188)	2.89871848
43	Abnormality of serum amino acid levels (HP:0003112)	2.87429274
44	Ketoacidosis (HP:0001993)	2.85072472
45	Gout (HP:0001997)	2.81772631
46	Malnutrition (HP:0004395)	2.78476426
47	Chromsome breakage (HP:0040012)	2.77736932
48	Steatorrhea (HP:0002570)	2.71996925
49	Abnormality of cells of the erythroid lineage (HP:0012130)	2.70094208
50	Abnormality of purine metabolism (HP:0004352)	2.69718776
51	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.67341282
52	Hypochromic microcytic anemia (HP:0004840)	2.66674196
53	Asymmetry of the thorax (HP:0001555)	2.65638214
54	Macrocytic anemia (HP:0001972)	2.62487661
55	Selective tooth agenesis (HP:0001592)	2.62486736
56	Esophageal varix (HP:0002040)	2.61847554
57	Abnormality of fatty-acid metabolism (HP:0004359)	2.59663909
58	Septate vagina (HP:0001153)	2.58348427
59	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.56799969
60	Abnormality of reticulocytes (HP:0004312)	2.50843533
61	Abnormal cartilage morphology (HP:0002763)	2.49377218
62	Acanthocytosis (HP:0001927)	2.48112621
63	Cortical dysplasia (HP:0002539)	2.42069522
64	Abnormality of glycolysis (HP:0004366)	2.41076033
65	Late onset (HP:0003584)	2.38524975
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.38413470
67	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.38413470
68	Hypoglycemic seizures (HP:0002173)	2.35568181
69	Spontaneous abortion (HP:0005268)	2.35192234
70	Back pain (HP:0003418)	2.35093681
71	Skin nodule (HP:0200036)	2.33254453
72	Ragged-red muscle fibers (HP:0003200)	2.31474917
73	Neonatal onset (HP:0003623)	2.31075683
74	Myocardial infarction (HP:0001658)	2.28801692
75	Lethargy (HP:0001254)	2.26917292
76	Metabolic acidosis (HP:0001942)	2.24248613
77	Pallor (HP:0000980)	2.22548332
78	Increased hepatocellular lipid droplets (HP:0006565)	2.21654851
79	Increased intramyocellular lipid droplets (HP:0012240)	2.21531915
80	Birth length less than 3rd percentile (HP:0003561)	2.19736695
81	Broad distal phalanx of finger (HP:0009836)	2.18005034
82	Abnormal number of erythroid precursors (HP:0012131)	2.16523919
83	Irritability (HP:0000737)	2.14638824
84	Breast carcinoma (HP:0003002)	2.14511913
85	Lipid accumulation in hepatocytes (HP:0006561)	2.14266931
86	Sensorimotor neuropathy (HP:0007141)	2.13685242
87	Aplastic anemia (HP:0001915)	2.12715104
88	Abnormality of transition element cation homeostasis (HP:0011030)	2.11440520
89	Abnormality of the umbilical cord (HP:0010881)	2.10214123
90	Truncus arteriosus (HP:0001660)	2.09471218
91	Abnormality of proline metabolism (HP:0010907)	2.08723684
92	Hydroxyprolinuria (HP:0003080)	2.08723684
93	Increased nuchal translucency (HP:0010880)	2.08520721
94	Poikilocytosis (HP:0004447)	2.05755805
95	Abnormality of the preputium (HP:0100587)	2.05098009
96	Vascular calcification (HP:0004934)	2.03389084
97	Increased muscle lipid content (HP:0009058)	2.01503701
98	Cerebral hypomyelination (HP:0006808)	2.00407291
99	Insomnia (HP:0100785)	1.99594395
100	Increased serum pyruvate (HP:0003542)	1.99584698
101	Cholelithiasis (HP:0001081)	1.99529528
102	Brushfield spots (HP:0001088)	1.99063712
103	Pancreatitis (HP:0001733)	1.98909961
104	Abnormality of the fetal cardiovascular system (HP:0010948)	1.98658469
105	Abnormal umbilical cord blood vessels (HP:0011403)	1.98658469
106	Single umbilical artery (HP:0001195)	1.98658469
107	Abnormality of the Achilles tendon (HP:0005109)	1.97927613
108	Cholecystitis (HP:0001082)	1.95310945
109	Abnormal gallbladder physiology (HP:0012438)	1.95310945
110	Nephroblastoma (Wilms tumor) (HP:0002667)	1.94921774
111	Sparse lateral eyebrow (HP:0005338)	1.94873806
112	Abnormal gallbladder morphology (HP:0012437)	1.92668750
113	Micronodular cirrhosis (HP:0001413)	1.91740846
114	Hyperglycemia (HP:0003074)	1.90643541
115	Abnormality of iron homeostasis (HP:0011031)	1.90466829
116	Medulloblastoma (HP:0002885)	1.90124074
117	Cutaneous melanoma (HP:0012056)	1.90025872
118	Oral leukoplakia (HP:0002745)	1.89065317
119	Rough bone trabeculation (HP:0100670)	1.87742642
120	Spinal cord lesions (HP:0100561)	1.86086893
121	Syringomyelia (HP:0003396)	1.86086893
122	Ileus (HP:0002595)	1.85081640
123	Abnormal large intestine physiology (HP:0012700)	1.84799557
124	Curly hair (HP:0002212)	1.83967417
125	Cerebral edema (HP:0002181)	1.83777874
126	Facial cleft (HP:0002006)	1.83547257
127	Upper limb muscle weakness (HP:0003484)	1.83414892
128	Hyperuricemia (HP:0002149)	1.83359251
129	Increased purine levels (HP:0004368)	1.83359251
130	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.82962965
131	Dicarboxylic aciduria (HP:0003215)	1.82962965
132	Hyperinsulinemic hypoglycemia (HP:0000825)	1.82738071
133	Bowel incontinence (HP:0002607)	1.81800665
134	Degeneration of anterior horn cells (HP:0002398)	1.81750756
135	Abnormality of the anterior horn cell (HP:0006802)	1.81750756
136	Proximal tubulopathy (HP:0000114)	1.80914459
137	Abnormality of chromosome stability (HP:0003220)	1.79805787
138	Reticulocytosis (HP:0001923)	1.79791241
139	Myelodysplasia (HP:0002863)	1.79327973
140	Long palpebral fissure (HP:0000637)	1.79033593
141	Cardiovascular calcification (HP:0011915)	1.78697018
142	Thrombophlebitis (HP:0004418)	1.78181993
143	Unilateral renal agenesis (HP:0000122)	1.77981107
144	Deep philtrum (HP:0002002)	1.77521896
145	Abnormality of the gallbladder (HP:0005264)	1.77380813
146	Ankyloglossia (HP:0010296)	1.76804841
147	Abnormality of the lower motor neuron (HP:0002366)	1.76347194
148	Multiple enchondromatosis (HP:0005701)	1.75505521
149	Orthostatic hypotension (HP:0001278)	1.74714494
150	Deep palmar crease (HP:0006191)	1.74280242
151	Short middle phalanx of the 5th finger (HP:0004220)	1.73845795
152	Overlapping toe (HP:0001845)	1.73600497
153	Neoplasm of the pancreas (HP:0002894)	1.73558058
154	Cafe-au-lait spot (HP:0000957)	1.73542943
155	Hypoparathyroidism (HP:0000829)	1.73102040
156	Embryonal renal neoplasm (HP:0011794)	1.72873320
157	Trismus (HP:0000211)	1.72740313
158	Clonus (HP:0002169)	1.72727901
159	Hyperparathyroidism (HP:0000843)	1.71955591
160	Increased serum lactate (HP:0002151)	1.69989379
161	Horseshoe kidney (HP:0000085)	1.69212741
162	Vomiting (HP:0002013)	1.68956568
163	Confusion (HP:0001289)	1.68868601
164	Glossoptosis (HP:0000162)	1.68320046
165	Proximal placement of thumb (HP:0009623)	1.68031682
166	Dysphonia (HP:0001618)	1.67872039
167	Rickets (HP:0002748)	1.67856613
168	Upper motor neuron abnormality (HP:0002127)	1.67816122
169	Death in infancy (HP:0001522)	1.67421443
170	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.66375081
171	Insidious onset (HP:0003587)	1.66108410
172	Termporal pattern (HP:0011008)	1.66108410
173	Megaloblastic anemia (HP:0001889)	1.66030912
174	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.65830986
175	Pseudobulbar signs (HP:0002200)	1.65478803
176	Systemic lupus erythematosus (HP:0002725)	1.65422394
177	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.65293170
178	Ankle clonus (HP:0011448)	1.64863913
179	Abnormal enzyme/coenzyme activity (HP:0012379)	1.64754375
180	Respiratory difficulties (HP:0002880)	1.64437229
181	Secondary amenorrhea (HP:0000869)	1.63223493
182	Status epilepticus (HP:0002133)	1.63163368
183	Death in childhood (HP:0003819)	1.63054435
184	Gastrointestinal carcinoma (HP:0002672)	1.61604449
185	Malignant gastrointestinal tract tumors (HP:0006749)	1.61604449
186	Mitral stenosis (HP:0001718)	1.61179845

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	4.27042824
2	NME2	3.62071328
3	PKN2	3.35865274
4	TRIB3	3.13221859
5	FRK	3.02033467
6	PBK	2.96279816
7	SCYL2	2.88350266
8	ERN1	2.63851368
9	SMG1	2.37965682
10	EPHA2	2.29873973
11	MST1R	2.28510237
12	MAP3K10	2.26556903
13	PRPF4B	2.23829140
14	CDK19	2.19973023
15	LATS1	2.13808613
16	ERBB4	2.05002983
17	SIK1	2.04021780
18	NEK1	1.97562167
19	LATS2	1.80901281
20	WEE1	1.78537911
21	BUB1	1.76767177
22	EIF2AK1	1.76293036
23	FGFR4	1.75318619
24	STK16	1.64409619
25	PTK6	1.55881380
26	TESK1	1.54065758
27	ZAK	1.46593182
28	CDC7	1.46336448
29	KSR2	1.45005360
30	EEF2K	1.43767401
31	FLT3	1.41713607
32	TESK2	1.40497051
33	MAP3K9	1.37299055
34	NEK2	1.36056971
35	MARK1	1.33877753
36	ACVR1B	1.28967728
37	RIPK1	1.27565657
38	TTK	1.26935374
39	MAP3K2	1.25613224
40	VRK2	1.24709337
41	MAPK11	1.22375958
42	MAP3K8	1.20902156
43	MET	1.15821272
44	KDR	1.15820568
45	MAP3K11	1.15706183
46	RPS6KB2	1.15147258
47	IRAK3	1.10818209
48	PLK4	1.05137107
49	STK38L	1.03055471
50	MAP2K2	1.02859347
51	CDK6	1.01157355
52	RPS6KA4	1.00622171
53	IRAK2	0.99454682
54	ARAF	0.98987379
55	SIK3	0.97078314
56	CDK12	0.96355866
57	MAPKAPK3	0.94883165
58	DYRK3	0.94662438
59	MAP2K4	0.94259134
60	DAPK1	0.92964904
61	DAPK2	0.92407415
62	CHEK1	0.92113456
63	NEK6	0.91743659
64	GRK6	0.90245909
65	AURKA	0.87923582
66	KSR1	0.87612725
67	BRD4	0.84749655
68	ABL2	0.84084864
69	PRKCI	0.82513460
70	CDK4	0.81693994
71	FGFR2	0.81175239
72	PTK2	0.80524203
73	ICK	0.80414451
74	ERBB2	0.80258792
75	PAK4	0.78989013
76	AURKB	0.78971268
77	ILK	0.78446409
78	MTOR	0.77823808
79	TLK1	0.77157934
80	MAP3K12	0.76303266
81	TAOK3	0.76212420
82	PLK1	0.75027984
83	CLK1	0.74479177
84	TGFBR1	0.73672527
85	PDK2	0.71622957
86	RAF1	0.71318368
87	MST4	0.69611418
88	CDK11A	0.68926901
89	LRRK2	0.68328214
90	CDK14	0.68299573
91	PLK3	0.68299182
92	PDK4	0.67999899
93	PDK3	0.67999899
94	MAP3K5	0.67713521
95	TRIM28	0.66911090
96	BRAF	0.66611031
97	CAMKK1	0.65027589
98	MAP2K1	0.64614081
99	STK4	0.63712353
100	PIM1	0.63463224
101	MAP3K3	0.63407137
102	DYRK1B	0.62543399
103	RPS6KB1	0.62429700
104	MAP2K6	0.60426827
105	VRK1	0.60315002
106	CDK18	0.60176037
107	CSNK1G3	0.60050710
108	PRKCZ	0.59848033
109	CDK15	0.59641012
110	PDGFRA	0.59141533
111	PASK	0.58876375
112	PIM2	0.58103230
113	EIF2AK3	0.57782085
114	STK3	0.57761312
115	RET	0.57704392
116	SRPK1	0.57539048
117	MELK	0.57095320
118	NME1	0.56686450
119	CHEK2	0.55764655
120	NEK9	0.55423965
121	DYRK2	0.55041802
122	AKT2	0.54947593
123	RPS6KA5	0.52923938
124	BRSK2	0.52490971
125	MINK1	0.51053267
126	ATM	0.50758381
127	TAOK1	0.48280929
128	AKT3	0.48125635
129	CDK1	0.48081270
130	BRSK1	0.47065560
131	PAK1	0.46210280
132	TAF1	0.45862382
133	FGFR1	0.44827512
134	TAOK2	0.43520347
135	TSSK6	0.42937915
136	BMX	0.41336649
137	MAP2K7	0.40149859
138	CSNK1E	0.40076124
139	ATR	0.39948967
140	CDK7	0.39547231
141	CSNK1A1L	0.39446635
142	JAK2	0.39434408
143	STK10	0.39269434
144	DAPK3	0.37215944
145	CSNK2A1	0.37015554
146	ALK	0.36401106
147	MAP2K3	0.32620460
148	CDK2	0.32578605
149	CSNK2A2	0.31850380
150	PRKAA1	0.31313826

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.10814150
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.57342148
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.41007618
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.38582921
5	Ribosome_Homo sapiens_hsa03010	3.17987982
6	Arginine biosynthesis_Homo sapiens_hsa00220	3.15340170
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.84218015
8	Base excision repair_Homo sapiens_hsa03410	2.57233124
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.57209452
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.48198554
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.25669034
12	Fatty acid degradation_Homo sapiens_hsa00071	2.21549714
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.19594807
14	Complement and coagulation cascades_Homo sapiens_hsa04610	2.19574268
15	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.09700918
16	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.09004507
17	mRNA surveillance pathway_Homo sapiens_hsa03015	2.01871784
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.99794474
19	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.97262411
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.92942158
21	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.90054965
22	RNA polymerase_Homo sapiens_hsa03020	1.83571169
23	One carbon pool by folate_Homo sapiens_hsa00670	1.83489043
24	Butanoate metabolism_Homo sapiens_hsa00650	1.82863997
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.77801416
26	Peroxisome_Homo sapiens_hsa04146	1.74502784
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.73218967
28	Propanoate metabolism_Homo sapiens_hsa00640	1.70812590
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.68065908
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.67882656
31	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.65946287
32	Folate biosynthesis_Homo sapiens_hsa00790	1.63045217
33	PPAR signaling pathway_Homo sapiens_hsa03320	1.58699416
34	Bile secretion_Homo sapiens_hsa04976	1.58544645
35	Fat digestion and absorption_Homo sapiens_hsa04975	1.57912752
36	Caffeine metabolism_Homo sapiens_hsa00232	1.57795430
37	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.55777589
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.55727068
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.53773572
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.48542388
41	Sulfur metabolism_Homo sapiens_hsa00920	1.45023538
42	Histidine metabolism_Homo sapiens_hsa00340	1.42782611
43	Carbon metabolism_Homo sapiens_hsa01200	1.40294664
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36977066
45	beta-Alanine metabolism_Homo sapiens_hsa00410	1.36926901
46	Fatty acid metabolism_Homo sapiens_hsa01212	1.35708612
47	Homologous recombination_Homo sapiens_hsa03440	1.32672762
48	Retinol metabolism_Homo sapiens_hsa00830	1.32230816
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.31150458
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31132960
51	Phenylalanine metabolism_Homo sapiens_hsa00360	1.28287220
52	Alcoholism_Homo sapiens_hsa05034	1.27391532
53	Sulfur relay system_Homo sapiens_hsa04122	1.26068820
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23690579
55	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.23399541
56	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.17969214
57	Vibrio cholerae infection_Homo sapiens_hsa05110	1.17852498
58	Tyrosine metabolism_Homo sapiens_hsa00350	1.16042828
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.09794726
60	Viral carcinogenesis_Homo sapiens_hsa05203	1.06333211
61	Non-small cell lung cancer_Homo sapiens_hsa05223	1.02872945
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.99075112
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98876622
64	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.97458148
65	Acute myeloid leukemia_Homo sapiens_hsa05221	0.96554836
66	Purine metabolism_Homo sapiens_hsa00230	0.96375640
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95409893
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90855844
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90664119
70	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89393644
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88519158
72	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.87296649
73	Glutathione metabolism_Homo sapiens_hsa00480	0.86608652
74	Pancreatic cancer_Homo sapiens_hsa05212	0.86098418
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.85526287
76	Oocyte meiosis_Homo sapiens_hsa04114	0.82844819
77	RNA degradation_Homo sapiens_hsa03018	0.82745537
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81159548
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.79748476
80	Colorectal cancer_Homo sapiens_hsa05210	0.79458281
81	Oxidative phosphorylation_Homo sapiens_hsa00190	0.78988510
82	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.77807641
83	Lysine degradation_Homo sapiens_hsa00310	0.77359244
84	Parkinsons disease_Homo sapiens_hsa05012	0.73988779
85	Shigellosis_Homo sapiens_hsa05131	0.73173740
86	ABC transporters_Homo sapiens_hsa02010	0.72836417
87	Huntingtons disease_Homo sapiens_hsa05016	0.72001871
88	Renal cell carcinoma_Homo sapiens_hsa05211	0.68103663
89	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.66920204
90	ErbB signaling pathway_Homo sapiens_hsa04012	0.66456015
91	Basal transcription factors_Homo sapiens_hsa03022	0.65266119
92	Glioma_Homo sapiens_hsa05214	0.64955066
93	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.63504914
94	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63179227
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63043289
96	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.61586663
97	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.58444754
98	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.57676999
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57402039
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54182125
101	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.52328172
102	VEGF signaling pathway_Homo sapiens_hsa04370	0.51283243
103	Hepatitis B_Homo sapiens_hsa05161	0.51107394
104	Prostate cancer_Homo sapiens_hsa05215	0.50447625
105	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.47607028
106	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46190811
107	Galactose metabolism_Homo sapiens_hsa00052	0.45075219
108	Protein export_Homo sapiens_hsa03060	0.44984322
109	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43833728
110	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.43687866
111	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.43252701
112	Metabolic pathways_Homo sapiens_hsa01100	0.43233173
113	Proteasome_Homo sapiens_hsa03050	0.42805930
114	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.40425579
115	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.39698341
116	RNA transport_Homo sapiens_hsa03013	0.39206818
117	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.39082487
118	Apoptosis_Homo sapiens_hsa04210	0.38771610
119	Prion diseases_Homo sapiens_hsa05020	0.38400317
120	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.37921395
121	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35322611
122	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.35155783
123	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.35132196
124	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34994700
125	DNA replication_Homo sapiens_hsa03030	0.34041583
126	Bladder cancer_Homo sapiens_hsa05219	0.32361937
127	MicroRNAs in cancer_Homo sapiens_hsa05206	0.32238611
128	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31850992
129	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.24752596
130	Insulin resistance_Homo sapiens_hsa04931	0.24515883
131	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.23449387
132	Thyroid cancer_Homo sapiens_hsa05216	0.21676419
133	Mismatch repair_Homo sapiens_hsa03430	0.21541885
134	Renin-angiotensin system_Homo sapiens_hsa04614	0.20618131
135	Fatty acid elongation_Homo sapiens_hsa00062	0.20445196
136	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.19453960
137	AMPK signaling pathway_Homo sapiens_hsa04152	0.14882347
138	Glucagon signaling pathway_Homo sapiens_hsa04922	0.12739720
139	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.12237350
140	Cell cycle_Homo sapiens_hsa04110	0.04930991
141	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.04082007
142	Insulin signaling pathway_Homo sapiens_hsa04910	0.02318350
143	p53 signaling pathway_Homo sapiens_hsa04115	0.02277345
144	Endometrial cancer_Homo sapiens_hsa05213	0.01178241
145	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.00984288
146	Spliceosome_Homo sapiens_hsa03040	0.00808090
147	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.00302546
148	mTOR signaling pathway_Homo sapiens_hsa04150	-0.0311005
149	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	-0.0209185
150	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.0142193

TMEM183A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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