TMEM184A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)9.91993596
2positive regulation of male gonad development (GO:2000020)6.97629630
3regulation of male gonad development (GO:2000018)6.91691257
4GDP-mannose metabolic process (GO:0019673)6.51522303
5* sex determination (GO:0007530)6.37307628
6desmosome organization (GO:0002934)6.29273371
7sex differentiation (GO:0007548)5.65505331
8COPI coating of Golgi vesicle (GO:0048205)5.63209083
9Golgi transport vesicle coating (GO:0048200)5.63209083
10regulation of meiosis I (GO:0060631)5.50047302
11male sex determination (GO:0030238)5.40360929
12cellular response to ATP (GO:0071318)5.33262633
13intestinal cholesterol absorption (GO:0030299)5.29312873
14piRNA metabolic process (GO:0034587)5.17955437
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.09760789
16macroautophagy (GO:0016236)5.05801295
17fusion of sperm to egg plasma membrane (GO:0007342)4.79046674
18nucleotide transmembrane transport (GO:1901679)4.76210824
19response to misfolded protein (GO:0051788)4.72114955
20positive regulation of protein kinase C signaling (GO:0090037)4.64075111
21drug transmembrane transport (GO:0006855)4.62095721
22oocyte development (GO:0048599)4.59429605
23protein retention in ER lumen (GO:0006621)4.57505236
24synaptonemal complex assembly (GO:0007130)4.41983733
25exocrine pancreas development (GO:0031017)4.35227494
263-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.33623180
27purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.33623180
28intestinal absorption (GO:0050892)4.28185389
29regulation of gonadotropin secretion (GO:0032276)4.27042071
30regulation of water loss via skin (GO:0033561)4.25164098
31synaptonemal complex organization (GO:0070193)4.24679944
32glutathione biosynthetic process (GO:0006750)4.14001120
33L-alpha-amino acid transmembrane transport (GO:1902475)4.13027601
34establishment of skin barrier (GO:0061436)4.12039330
35COPII vesicle coating (GO:0048208)4.08075580
36nucleoside transmembrane transport (GO:1901642)4.00214925
37bundle of His cell to Purkinje myocyte communication (GO:0086069)3.97936879
38purine ribonucleotide transport (GO:0015868)3.95846731
39primary alcohol catabolic process (GO:0034310)3.91318177
40negative regulation of digestive system process (GO:0060457)3.90665154
41activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.90145122
42purinergic nucleotide receptor signaling pathway (GO:0035590)3.85932362
43proline biosynthetic process (GO:0006561)3.84918103
44purine nucleotide transport (GO:0015865)3.80326953
45calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.77356891
46male meiosis (GO:0007140)3.77059275
47flavonoid metabolic process (GO:0009812)3.76964630
48cellular anion homeostasis (GO:0030002)3.75760381
49anatomical structure regression (GO:0060033)3.74776487
50multicellular organismal water homeostasis (GO:0050891)3.74225208
51nonribosomal peptide biosynthetic process (GO:0019184)3.72133972
52Leydig cell differentiation (GO:0033327)3.70250747
53positive regulation of nuclease activity (GO:0032075)3.69293647
54negative regulation of cell aging (GO:0090344)3.68444988
55DNA methylation involved in gamete generation (GO:0043046)3.68427515
56adenine nucleotide transport (GO:0051503)3.67222538
57endocrine pancreas development (GO:0031018)3.66907157
58G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.65799867
59transepithelial transport (GO:0070633)3.63826372
60peristalsis (GO:0030432)3.63287877
61proline metabolic process (GO:0006560)3.62347733
62phosphate ion homeostasis (GO:0055062)3.61371415
63trivalent inorganic anion homeostasis (GO:0072506)3.61371415
64erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.60949498
65L-phenylalanine catabolic process (GO:0006559)3.60949498
66sensory perception of taste (GO:0050909)3.55249673
67retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.53769098
68reverse cholesterol transport (GO:0043691)3.53183701
69poly(A)+ mRNA export from nucleus (GO:0016973)3.52734250
70urinary tract smooth muscle contraction (GO:0014848)3.52063018
71alpha-linolenic acid metabolic process (GO:0036109)3.50458452
72DNA strand renaturation (GO:0000733)3.42455960
73sphingomyelin metabolic process (GO:0006684)3.41934502
74regulation of fatty acid beta-oxidation (GO:0031998)3.40192058
75positive regulation of fatty acid beta-oxidation (GO:0032000)3.40038818
76nucleotide-sugar biosynthetic process (GO:0009226)3.39264162
77protein carboxylation (GO:0018214)3.38636994
78peptidyl-glutamic acid carboxylation (GO:0017187)3.38636994
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.38064840
80L-phenylalanine metabolic process (GO:0006558)3.38064840
81rRNA methylation (GO:0031167)3.38034179
82endoplasmic reticulum unfolded protein response (GO:0030968)3.37852597
83regulation of nuclease activity (GO:0032069)3.30646340
84plasma membrane fusion (GO:0045026)3.29441399
85cellular response to topologically incorrect protein (GO:0035967)3.28661529
86drug transport (GO:0015893)3.27933195
87ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.27798479
88cellular response to unfolded protein (GO:0034620)3.27590143
89diol metabolic process (GO:0034311)3.27184704
90glomerular basement membrane development (GO:0032836)3.26966836
91regulation of hydrogen peroxide metabolic process (GO:0010310)3.22981826
92drug catabolic process (GO:0042737)3.21440035
93response to nitrosative stress (GO:0051409)3.14475245
94iron coordination entity transport (GO:1901678)3.13925040
95ER-nucleus signaling pathway (GO:0006984)3.13548474
96alkaloid metabolic process (GO:0009820)3.12734237
97hemoglobin metabolic process (GO:0020027)3.12404168
98epoxygenase P450 pathway (GO:0019373)3.11290979
99peptide hormone processing (GO:0016486)3.09302181
100male meiosis I (GO:0007141)3.08994546
101response to ATP (GO:0033198)3.08598677
102keratinocyte development (GO:0003334)3.08574061
103regulation of cholesterol metabolic process (GO:0090181)3.08485196
104water homeostasis (GO:0030104)3.07324764
105regulation of cholesterol biosynthetic process (GO:0045540)3.07210403
106cysteine metabolic process (GO:0006534)3.05897695
107sequestering of metal ion (GO:0051238)3.05827288
108exogenous drug catabolic process (GO:0042738)3.05698813
109meiotic chromosome segregation (GO:0045132)3.05000402
110digestion (GO:0007586)3.04794232
111cilium or flagellum-dependent cell motility (GO:0001539)3.00853876
112positive regulation of meiosis (GO:0045836)3.00502670
113regulation of skeletal muscle contraction (GO:0014819)3.00014680
114glandular epithelial cell differentiation (GO:0002067)2.99841145
115apoptotic cell clearance (GO:0043277)2.98578871
116sulfur amino acid catabolic process (GO:0000098)2.97373413
117vitamin transmembrane transport (GO:0035461)2.96581414
118sulfur compound transport (GO:0072348)2.95344807
119epithelial cell fate commitment (GO:0072148)2.94464093
120positive regulation of meiotic cell cycle (GO:0051446)2.94060925
121growth hormone secretion (GO:0030252)2.93234868
122semaphorin-plexin signaling pathway (GO:0071526)2.93032055
123O-glycan processing (GO:0016266)2.91270677
124positive regulation of receptor biosynthetic process (GO:0010870)2.90820507
125ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.88949774
126ethanol oxidation (GO:0006069)2.88849597
127response to food (GO:0032094)2.88833193
128nucleoside transport (GO:0015858)2.86774488
129protein maturation by protein folding (GO:0022417)2.86367039
130renal absorption (GO:0070293)2.85792804
131heme transport (GO:0015886)2.85058929
132response to endoplasmic reticulum stress (GO:0034976)2.83378870
133lung epithelium development (GO:0060428)2.82852939
134sphingoid metabolic process (GO:0046519)2.82720868
135regulation of hippo signaling (GO:0035330)2.82087133
136regulation of guanylate cyclase activity (GO:0031282)2.81720915
137regulation of female gonad development (GO:2000194)2.81316314
138xenobiotic catabolic process (GO:0042178)2.79973948
139nucleotide transport (GO:0006862)2.79904580
140regulation of phospholipase A2 activity (GO:0032429)2.76334105
141negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.75820507
142ovulation cycle (GO:0042698)2.75565434
143very-low-density lipoprotein particle assembly (GO:0034379)2.73406382
144negative regulation of meiosis (GO:0045835)2.72606481
145bile acid and bile salt transport (GO:0015721)2.71186750
146peptide biosynthetic process (GO:0043043)2.70915267
147response to topologically incorrect protein (GO:0035966)2.70292724
148Sertoli cell development (GO:0060009)2.70215958
149zinc ion transport (GO:0006829)2.70122726
150ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.69726380
151nucleoside bisphosphate biosynthetic process (GO:0033866)2.69726380
152purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.69726380
153homocysteine metabolic process (GO:0050667)2.68833636
154glutamine family amino acid biosynthetic process (GO:0009084)2.68648130
155rRNA modification (GO:0000154)2.68066928
156regulation of cholesterol homeostasis (GO:2000188)2.67876730
157ethanol metabolic process (GO:0006067)2.67602784
158adenosine receptor signaling pathway (GO:0001973)2.67519276
159positive regulation of fatty acid oxidation (GO:0046321)2.66719554
160valine metabolic process (GO:0006573)2.66565121
161transcytosis (GO:0045056)2.66280317
162signal peptide processing (GO:0006465)2.66065628
163embryonic foregut morphogenesis (GO:0048617)2.65692803
164endothelial cell chemotaxis (GO:0035767)2.65665599
165cellular response to leptin stimulus (GO:0044320)2.64957843
166diacylglycerol metabolic process (GO:0046339)2.62975407
167sphingosine metabolic process (GO:0006670)2.62512882
168positive regulation of keratinocyte differentiation (GO:0045618)2.61959351
169mannose metabolic process (GO:0006013)2.61699283
170cornea development in camera-type eye (GO:0061303)2.61695157
171vesicle coating (GO:0006901)2.61586091
172high-density lipoprotein particle remodeling (GO:0034375)2.61145333
173positive regulation of epidermal cell differentiation (GO:0045606)2.59730359
174lens fiber cell differentiation (GO:0070306)2.59635419
175aromatic amino acid family catabolic process (GO:0009074)2.59574232
176regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.58931588
177cell-cell junction maintenance (GO:0045217)2.58643604
1784-hydroxyproline metabolic process (GO:0019471)2.58519760
179response to unfolded protein (GO:0006986)2.58061074
180regulation of fatty acid oxidation (GO:0046320)2.57802026
181intestinal epithelial cell development (GO:0060576)2.56362399
182receptor guanylyl cyclase signaling pathway (GO:0007168)2.55618044
183UV protection (GO:0009650)2.55300617
184multicellular organismal aging (GO:0010259)2.53453923
185phosphatidylcholine biosynthetic process (GO:0006656)2.53265627
186positive regulation of reproductive process (GO:2000243)2.52798987
187urea cycle (GO:0000050)2.52333782
188misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.51545101
189urea metabolic process (GO:0019627)2.51150235
190very long-chain fatty acid metabolic process (GO:0000038)2.49281633
191androgen biosynthetic process (GO:0006702)2.49085934
192hormone catabolic process (GO:0042447)2.47643753
193atrioventricular valve morphogenesis (GO:0003181)2.46709324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human6.08365563
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.09903722
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.24075425
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.03910816
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.79152976
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.62530525
7GATA1_22025678_ChIP-Seq_K562_Human3.36414079
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.11434506
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.81309327
10CLOCK_20551151_ChIP-Seq_293T_Human2.75107814
11P68_20966046_ChIP-Seq_HELA_Human2.67501389
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.57440363
13ZNF263_19887448_ChIP-Seq_K562_Human2.47161164
14VDR_21846776_ChIP-Seq_THP-1_Human2.45915988
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.39521688
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21326099
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15729235
18GATA4_25053715_ChIP-Seq_YYC3_Human2.05985250
19BCOR_27268052_Chip-Seq_Bcells_Human2.02511056
20E2F1_20622854_ChIP-Seq_HELA_Human2.02287495
21* SMC4_20622854_ChIP-Seq_HELA_Human2.00956312
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.93197003
23BCL6_27268052_Chip-Seq_Bcells_Human1.90807687
24TET1_21451524_ChIP-Seq_MESCs_Mouse1.90474408
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.86449331
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83397749
27PHF8_20622854_ChIP-Seq_HELA_Human1.80259981
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78667186
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74914527
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74914527
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74914527
32GATA6_25053715_ChIP-Seq_YYC3_Human1.73801680
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73012344
34MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.64948510
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.64793190
36* RUNX1_27514584_Chip-Seq_MCF-7_Human1.64495238
37SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62483735
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57333989
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56674279
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55920558
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.55879843
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55739818
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53961157
44* TP63_22573176_ChIP-Seq_HFKS_Human1.53558992
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.51184342
46* CREB1_26743006_Chip-Seq_LNCaP_Human1.51060889
47FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49096819
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48433892
49RARA_24833708_ChIP-Seq_LIVER_Mouse1.47337287
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45018649
51ATF3_27146783_Chip-Seq_COLON_Human1.44135148
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43537937
53RXRA_24833708_ChIP-Seq_LIVER_Mouse1.42790556
54CTCF_20526341_ChIP-Seq_ESCs_Human1.42705877
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41895620
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40845450
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39632175
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39304388
59* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39229527
60SA1_27219007_Chip-Seq_Bcells_Human1.37927305
61ERA_21632823_ChIP-Seq_H3396_Human1.37916643
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37251510
63GATA3_24758297_ChIP-Seq_MCF-7_Human1.35819702
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34198004
65LXR_22292898_ChIP-Seq_THP-1_Human1.32820366
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32146044
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.31835835
68FOXP1_21924763_ChIP-Seq_HESCs_Human1.31628727
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29746256
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29416080
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29383101
72KLF5_25053715_ChIP-Seq_YYC3_Human1.28904697
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.27171615
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27161324
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26477742
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24267682
77GATA1_19941826_ChIP-Seq_K562_Human1.24024496
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23742794
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23598719
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23042446
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23018529
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22852367
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21908135
84SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21727701
85MAF_26560356_Chip-Seq_TH2_Human1.21482009
86SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21350038
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20309631
88* CHD1_26751641_Chip-Seq_LNCaP_Human1.20306549
89JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.19330182
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18438998
91CTCF_21964334_Chip-Seq_Bcells_Human1.16167593
92NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.14528518
93NCOR1_26117541_ChIP-Seq_K562_Human1.13675646
94P53_21459846_ChIP-Seq_SAOS-2_Human1.13584085
95SOX2_20726797_ChIP-Seq_SW620_Human1.13234313
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.12937238
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.12717499
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.11367709
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.09486073
100HNF4A_19822575_ChIP-Seq_HepG2_Human1.08731052
101FOXA1_25552417_ChIP-Seq_VCAP_Human1.08364543
102KDM2B_26808549_Chip-Seq_K562_Human1.08001676
103ETS1_21867929_ChIP-Seq_TH2_Mouse1.07213666
104P300_27268052_Chip-Seq_Bcells_Human1.07019906
105* TCF7_22412390_ChIP-Seq_EML_Mouse1.06834580
106XRN2_22483619_ChIP-Seq_HELA_Human1.06713450
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05473277
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05182875
109ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04176973
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03734992
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03303854
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02577376
113VDR_24763502_ChIP-Seq_THP-1_Human1.01556005
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01049372
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00759167
116TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00758615
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00404266
118P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00390191
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00013833
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99849734
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99066917
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98889406
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.98032427
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.98032427
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96578676
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96187598
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96144365
128RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96081050
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95890051
130CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95869295
131CTCF_27219007_Chip-Seq_Bcells_Human0.92493749
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89068774
133KDM2B_26808549_Chip-Seq_DND41_Human0.88782077
134SA1_27219007_Chip-Seq_ERYTHROID_Human0.88204192
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87191898
136* GATA1_19941827_ChIP-Seq_MEL_Mouse0.86406362
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86249799
138CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85192643
139TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85137179
140GATA2_19941826_ChIP-Seq_K562_Human0.83720843
141RARB_24833708_ChIP-Seq_LIVER_Mouse0.81770849
142KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81443048
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80836424
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80776880
145TP53_22127205_ChIP-Seq_IMR90_Human0.80028305
146CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78051904
147PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77167218
148ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76898823
149HIF1A_21447827_ChIP-Seq_MCF-7_Human0.75569408
150CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74484179
151FOXH1_21741376_ChIP-Seq_ESCs_Human0.74172114
152SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72833166
153SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.72699361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.20218590
2MP0003195_calcinosis4.92951526
3MP0002139_abnormal_hepatobiliary_system4.44603982
4MP0005377_hearing/vestibular/ear_phenot4.39768774
5MP0003878_abnormal_ear_physiology4.39768774
6MP0003136_yellow_coat_color3.93973622
7MP0005409_darkened_coat_color3.91110447
8MP0001986_abnormal_taste_sensitivity3.67458622
9MP0005174_abnormal_tail_pigmentation3.37224187
10MP0001666_abnormal_nutrient_absorption3.23824708
11MP0005365_abnormal_bile_salt3.20675054
12MP0008877_abnormal_DNA_methylation3.06999886
13MP0001188_hyperpigmentation2.99255788
14MP0005171_absent_coat_pigmentation2.98359271
15MP0005360_urolithiasis2.92411717
16MP0004381_abnormal_hair_follicle2.77337235
17MP0005423_abnormal_somatic_nervous2.74912313
18MP0005501_abnormal_skin_physiology2.52504117
19MP0005085_abnormal_gallbladder_physiolo2.51063361
20MP0004043_abnormal_pH_regulation2.50034191
21MP0001661_extended_life_span2.33504913
22MP0001873_stomach_inflammation2.33157034
23MP0003879_abnormal_hair_cell2.28986889
24MP0005083_abnormal_biliary_tract2.26638383
25MP0005220_abnormal_exocrine_pancreas2.24380681
26MP0003252_abnormal_bile_duct2.20856200
27MP0003300_gastrointestinal_ulcer2.19057691
28MP0003283_abnormal_digestive_organ2.18650524
29MP0003453_abnormal_keratinocyte_physiol2.08829100
30MP0009780_abnormal_chondrocyte_physiolo1.96390098
31MP0000566_synostosis1.92691127
32MP0005647_abnormal_sex_gland1.86479986
33MP0003868_abnormal_feces_composition1.84975052
34MP0003786_premature_aging1.83389891
35MP0010234_abnormal_vibrissa_follicle1.78595962
36MP0010678_abnormal_skin_adnexa1.71525410
37MP0003045_fibrosis1.68290248
38MP0009384_cardiac_valve_regurgitation1.68012126
39MP0000538_abnormal_urinary_bladder1.66161797
40MP0008875_abnormal_xenobiotic_pharmacok1.65320330
41MP0001944_abnormal_pancreas_morphology1.57099455
42MP0005410_abnormal_fertilization1.56518688
43MP0002254_reproductive_system_inflammat1.50064183
44MP0000579_abnormal_nail_morphology1.49347089
45MP0003866_abnormal_defecation1.49214384
46MP0001216_abnormal_epidermal_layer1.47888616
47MP0000383_abnormal_hair_follicle1.44742041
48MP0002877_abnormal_melanocyte_morpholog1.44538842
49MP0004264_abnormal_extraembryonic_tissu1.44058990
50MP0010329_abnormal_lipoprotein_level1.42279227
51MP0001502_abnormal_circadian_rhythm1.41395673
52MP0001968_abnormal_touch/_nociception1.40896289
53MP0000013_abnormal_adipose_tissue1.40511557
54MP0002693_abnormal_pancreas_physiology1.38760516
55MP0002210_abnormal_sex_determination1.37677271
56MP0004782_abnormal_surfactant_physiolog1.35745692
57MP0001929_abnormal_gametogenesis1.35724534
58MP0001145_abnormal_male_reproductive1.35039150
59MP0009643_abnormal_urine_homeostasis1.31941798
60MP0010771_integument_phenotype1.31317488
61MP0000678_abnormal_parathyroid_gland1.29185115
62MP0004147_increased_porphyrin_level1.27824294
63MP0002876_abnormal_thyroid_physiology1.26879960
64MP0002168_other_aberrant_phenotype1.24781842
65MP0002249_abnormal_larynx_morphology1.23735861
66MP0001727_abnormal_embryo_implantation1.23136590
67MP0009379_abnormal_foot_pigmentation1.21429052
68MP0005332_abnormal_amino_acid1.21192989
69MP0002138_abnormal_hepatobiliary_system1.20790171
70MP0000015_abnormal_ear_pigmentation1.19730181
71MP0000377_abnormal_hair_follicle1.13793011
72MP0000653_abnormal_sex_gland1.12400737
73MP0004858_abnormal_nervous_system1.12396806
74MP0000609_abnormal_liver_physiology1.11661486
75MP0005408_hypopigmentation1.10924741
76MP0008961_abnormal_basal_metabolism1.10551082
77MP0000462_abnormal_digestive_system1.09146550
78MP0001756_abnormal_urination1.07250824
79MP0003183_abnormal_peptide_metabolism1.06301117
80MP0003698_abnormal_male_reproductive1.05518247
81MP0000639_abnormal_adrenal_gland1.05001573
82MP0010386_abnormal_urinary_bladder1.03420089
83MP0002118_abnormal_lipid_homeostasis1.01874275
84MP0000537_abnormal_urethra_morphology1.01214307
85MP0000003_abnormal_adipose_tissue1.01190290
86MP0004019_abnormal_vitamin_homeostasis1.00991354
87MP0002896_abnormal_bone_mineralization0.99887236
88MP0009931_abnormal_skin_appearance0.99745024
89MP0002078_abnormal_glucose_homeostasis0.98606914
90MP0000367_abnormal_coat/_hair0.98110280
91MP0003936_abnormal_reproductive_system0.97981943
92MP0004272_abnormal_basement_membrane0.97466072
93MP0001346_abnormal_lacrimal_gland0.96670439
94MP0003953_abnormal_hormone_level0.93700338
95MP0002160_abnormal_reproductive_system0.93576227
96MP0003315_abnormal_perineum_morphology0.92679350
97MP0005076_abnormal_cell_differentiation0.92551429
98MP0006054_spinal_hemorrhage0.92455966
99MP0002796_impaired_skin_barrier0.91869329
100MP0002928_abnormal_bile_duct0.91460898
101MP0000470_abnormal_stomach_morphology0.91443976
102MP0005636_abnormal_mineral_homeostasis0.90659274
103MP0002098_abnormal_vibrissa_morphology0.89951716
104MP0001765_abnormal_ion_homeostasis0.88210462
105MP0002136_abnormal_kidney_physiology0.87924359
106MP0003705_abnormal_hypodermis_morpholog0.87318746
107MP0003119_abnormal_digestive_system0.86389204
108MP0001664_abnormal_digestion0.84267278
109MP0003191_abnormal_cellular_cholesterol0.83721214
110MP0005248_abnormal_Harderian_gland0.83132169
111MP0005084_abnormal_gallbladder_morpholo0.82091063
112MP0000751_myopathy0.82010857
113MP0002909_abnormal_adrenal_gland0.81962449
114MP0000613_abnormal_salivary_gland0.80233930
115MP0005058_abnormal_lysosome_morphology0.77435691
116MP0008872_abnormal_physiological_respon0.76611333
117MP0000467_abnormal_esophagus_morphology0.76094946
118MP0002736_abnormal_nociception_after0.75531555
119MP0005584_abnormal_enzyme/coenzyme_acti0.74078403
120MP0005389_reproductive_system_phenotype0.73859978
121MP0009840_abnormal_foam_cell0.71164100
122MP0005319_abnormal_enzyme/_coenzyme0.71132244
123MP0005375_adipose_tissue_phenotype0.70505259
124MP0001764_abnormal_homeostasis0.70294751
125MP0003115_abnormal_respiratory_system0.69015352
126MP0000477_abnormal_intestine_morphology0.68659489
127MP0000627_abnormal_mammary_gland0.67518833
128MP0001881_abnormal_mammary_gland0.66703093
129MP0001348_abnormal_lacrimal_gland0.66505056
130MP0002638_abnormal_pupillary_reflex0.66374311
131MP0005330_cardiomyopathy0.64951562
132MP0005448_abnormal_energy_balance0.64899826
133MP0004185_abnormal_adipocyte_glucose0.64871861
134MP0005666_abnormal_adipose_tissue0.64661819
135MP0003693_abnormal_embryo_hatching0.64296788
136MP0005310_abnormal_salivary_gland0.64248108
137MP0002060_abnormal_skin_morphology0.64109508
138MP0003806_abnormal_nucleotide_metabolis0.62765084
139MP0005670_abnormal_white_adipose0.61119873
140MP0010155_abnormal_intestine_physiology0.60868570
141MP0005451_abnormal_body_composition0.60571904
142MP0003959_abnormal_lean_body0.59624544
143MP0005395_other_phenotype0.58842663
144MP0000427_abnormal_hair_cycle0.57913746
145MP0004947_skin_inflammation0.56903574
146MP0001919_abnormal_reproductive_system0.56572174
147MP0004885_abnormal_endolymph0.55904257
148MP0000598_abnormal_liver_morphology0.55781061
149MP0003011_delayed_dark_adaptation0.53261584
150MP0005551_abnormal_eye_electrophysiolog0.52736943
151MP0003638_abnormal_response/metabolism_0.52699484

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.70960907
2Gonadal dysgenesis (HP:0000133)7.01810414
3Testicular atrophy (HP:0000029)4.81333910
4Abnormal sex determination (HP:0012244)4.74517795
5Sex reversal (HP:0012245)4.74517795
6Gonadotropin excess (HP:0000837)4.69312317
7Testicular neoplasm (HP:0010788)4.62613063
8Rib fusion (HP:0000902)4.51778795
9Male pseudohermaphroditism (HP:0000037)4.36613636
10Hypoglycemic coma (HP:0001325)4.34524363
11Hypoglycemic seizures (HP:0002173)4.23480944
12Hyperinsulinemic hypoglycemia (HP:0000825)4.20268889
13Popliteal pterygium (HP:0009756)4.07108112
1411 pairs of ribs (HP:0000878)3.99809501
15Symptomatic seizures (HP:0011145)3.96025220
16Akinesia (HP:0002304)3.95135844
17Hand muscle atrophy (HP:0009130)3.94636527
18Hypoplasia of the uterus (HP:0000013)3.93719204
19Azoospermia (HP:0000027)3.90235944
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.66212127
21Congenital stationary night blindness (HP:0007642)3.64471372
22Hemorrhage of the eye (HP:0011885)3.59286069
23Decreased circulating renin level (HP:0003351)3.53992931
24Lip pit (HP:0100267)3.53716639
25Vaginal fistula (HP:0004320)3.47825242
26Poikiloderma (HP:0001029)3.46057766
27Widely patent fontanelles and sutures (HP:0004492)3.41728291
28Ulnar bowing (HP:0003031)3.40205886
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.39883592
30Enlarged epiphyses (HP:0010580)3.38054788
31Late onset (HP:0003584)3.34079859
32Facial hemangioma (HP:0000329)3.23468737
33Metaphyseal cupping (HP:0003021)3.22284746
34Facial diplegia (HP:0001349)3.18698802
35Intestinal fistula (HP:0100819)3.16479262
36Abnormality of male internal genitalia (HP:0000022)3.14825281
37Aplasia of the musculature (HP:0100854)3.14470825
38Rectal fistula (HP:0100590)3.14244601
39Rectovaginal fistula (HP:0000143)3.14244601
40Intrahepatic cholestasis (HP:0001406)3.14178406
41Aplasia/hypoplasia of the uterus (HP:0008684)3.13782027
42Pili torti (HP:0003777)3.13040492
43Germ cell neoplasia (HP:0100728)3.09710006
44Right ventricular cardiomyopathy (HP:0011663)3.06896170
45Infertility (HP:0000789)3.06753041
46Secondary amenorrhea (HP:0000869)3.00038239
47Attenuation of retinal blood vessels (HP:0007843)2.95556098
48Ketoacidosis (HP:0001993)2.93664231
49Abnormal spermatogenesis (HP:0008669)2.91337643
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.89029805
51Delayed epiphyseal ossification (HP:0002663)2.88655079
52Distal upper limb amyotrophy (HP:0007149)2.86218808
53Upper limb amyotrophy (HP:0009129)2.86218808
54Rectal prolapse (HP:0002035)2.84993976
55Hyperglycemia (HP:0003074)2.83039852
56Coronal craniosynostosis (HP:0004440)2.79249806
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.77254669
58Gout (HP:0001997)2.76537629
59Chorioretinal atrophy (HP:0000533)2.76135663
60Diaphragmatic weakness (HP:0009113)2.73171436
61Tubular atrophy (HP:0000092)2.66103640
62Abnormality of nail color (HP:0100643)2.63507457
63Abnormality of the intrinsic pathway (HP:0010989)2.63205450
64Flat occiput (HP:0005469)2.62795536
65Missing ribs (HP:0000921)2.62676832
66Ketosis (HP:0001946)2.62161304
67Abnormal hair laboratory examination (HP:0003328)2.61203598
68Abnormal pancreas size (HP:0012094)2.59866004
69Tongue fasciculations (HP:0001308)2.59267329
70Abnormality of the costochondral junction (HP:0000919)2.58852471
71Stridor (HP:0010307)2.56829591
72Turricephaly (HP:0000262)2.55319796
73Myopathic facies (HP:0002058)2.52578040
74Abnormality of chloride homeostasis (HP:0011422)2.51659788
75Fat malabsorption (HP:0002630)2.49550625
76Abnormality of renin-angiotensin system (HP:0000847)2.47669984
77Abnormal albumin level (HP:0012116)2.46913001
78Hypoalbuminemia (HP:0003073)2.46913001
79Conjugated hyperbilirubinemia (HP:0002908)2.44882220
80Squamous cell carcinoma (HP:0002860)2.42467263
81Deep venous thrombosis (HP:0002625)2.42460276
82Nausea (HP:0002018)2.41479860
83Annular pancreas (HP:0001734)2.41368392
84Bony spicule pigmentary retinopathy (HP:0007737)2.41113106
85Mesangial abnormality (HP:0001966)2.40479829
86Abdominal distention (HP:0003270)2.40417697
87Hydroxyprolinuria (HP:0003080)2.39835696
88Abnormality of proline metabolism (HP:0010907)2.39835696
89Amelogenesis imperfecta (HP:0000705)2.37455674
90Hypobetalipoproteinemia (HP:0003563)2.36581386
91Hypophosphatemic rickets (HP:0004912)2.36450128
92Pterygium (HP:0001059)2.32310937
93Xanthomatosis (HP:0000991)2.31080234
94Ankle clonus (HP:0011448)2.29777094
95Pendular nystagmus (HP:0012043)2.29261668
96Patellar aplasia (HP:0006443)2.28381688
97Diminished movement (HP:0002374)2.25194861
98Muscle fibrillation (HP:0010546)2.24931899
99Aplasia/Hypoplasia of the patella (HP:0006498)2.24565603
100Large for gestational age (HP:0001520)2.20477919
101Abnormality of endocrine pancreas physiology (HP:0012093)2.18610570
102Abnormality of the pancreatic islet cells (HP:0006476)2.18610570
103Fetal akinesia sequence (HP:0001989)2.16173693
104Acanthocytosis (HP:0001927)2.14425679
105Joint stiffness (HP:0001387)2.13016161
106Amniotic constriction ring (HP:0009775)2.12056517
107Abnormality of placental membranes (HP:0011409)2.12056517
108Abnormality of sulfur amino acid metabolism (HP:0004339)2.11454860
109Neonatal onset (HP:0003623)2.10494375
110Wide cranial sutures (HP:0010537)2.08850613
111Curly hair (HP:0002212)2.07002284
112Dyschromatopsia (HP:0007641)2.06796585
113Joint hemorrhage (HP:0005261)2.06239839
114Sparse lateral eyebrow (HP:0005338)2.05603926
115Insulin resistance (HP:0000855)2.05082972
116Back pain (HP:0003418)2.03951779
117Flat acetabular roof (HP:0003180)2.02096512
118Cheilitis (HP:0100825)2.02044822
119Short chin (HP:0000331)2.01330372
120Abnormality of the common coagulation pathway (HP:0010990)2.00003815
121Villous atrophy (HP:0011473)1.99792157
122Abnormality of small intestinal villus morphology (HP:0011472)1.99792157
123Generalized aminoaciduria (HP:0002909)1.98408136
124Abnormality of purine metabolism (HP:0004352)1.97684460
125Bowing of the arm (HP:0006488)1.96994456
126Bowed forearm bones (HP:0003956)1.96994456
127Protuberant abdomen (HP:0001538)1.96675361
128Abnormal drinking behavior (HP:0030082)1.95938523
129Polydipsia (HP:0001959)1.95938523
130Hyperglycinuria (HP:0003108)1.95609774
131Hypolipoproteinemia (HP:0010981)1.95570583
132Insulin-resistant diabetes mellitus (HP:0000831)1.94816114
133Capillary hemangiomas (HP:0005306)1.94526129
134Chronic bronchitis (HP:0004469)1.94461625
135Occipital encephalocele (HP:0002085)1.94435231
136Hyperactive renin-angiotensin system (HP:0000841)1.93047777
137Mucopolysacchariduria (HP:0008155)1.91318102
138Urinary glycosaminoglycan excretion (HP:0003541)1.91318102
139Hyponatremia (HP:0002902)1.90730299
140Depressed nasal tip (HP:0000437)1.90657363
141Abnormality of calcium-phosphate metabolism (HP:0100530)1.90633724
142Confusion (HP:0001289)1.90010402
143Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89922830
144Alopecia of scalp (HP:0002293)1.89803007
145Exocrine pancreatic insufficiency (HP:0001738)1.86185507
146Neonatal respiratory distress (HP:0002643)1.85950240
147Abnormality of renal excretion (HP:0011036)1.85809976
148Abnormal pupillary function (HP:0007686)1.85782756
149Anteriorly placed anus (HP:0001545)1.85452460
150Polycystic ovaries (HP:0000147)1.85082983
151Clonus (HP:0002169)1.84918133
152Primary adrenal insufficiency (HP:0008207)1.84093438
153Unilateral renal agenesis (HP:0000122)1.82166429
154Easy fatigability (HP:0003388)1.81827250
155Type I diabetes mellitus (HP:0100651)1.81083276
156Malnutrition (HP:0004395)1.81008409
157Hypoventilation (HP:0002791)1.80132810
158Thin bony cortex (HP:0002753)1.80122728
159Hyperkalemia (HP:0002153)1.79389003
160Hypoalphalipoproteinemia (HP:0003233)1.78339794
161Hypotrichosis (HP:0001006)1.78289402
162Abnormality of the musculature of the hand (HP:0001421)1.77417356
163Global brain atrophy (HP:0002283)1.75804904
164Abnormality of the nasal septum (HP:0000419)1.75588440
165Fatigable weakness (HP:0003473)1.74906059
166Abnormality of the neuromuscular junction (HP:0003398)1.74906059
167Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70013224
168Lymphangioma (HP:0100764)1.68085205
169Hyperbilirubinemia (HP:0002904)1.67252034
170Dysostosis multiplex (HP:0000943)1.66889753
171Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66295332
172Abnormality of polysaccharide metabolism (HP:0011012)1.66295332
173Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66295332
174Micronodular cirrhosis (HP:0001413)1.66250078
175Prolonged partial thromboplastin time (HP:0003645)1.65333161
176Hyperparathyroidism (HP:0000843)1.62933111
177Stage 5 chronic kidney disease (HP:0003774)1.61824482
178Hepatocellular carcinoma (HP:0001402)1.61545336
179Pancreatic islet-cell hyperplasia (HP:0004510)1.59753237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.33335628
2TRIB33.44398336
3WNK33.31201562
4ERN13.28549188
5TYRO33.27302993
6WNK43.16735725
7CDK123.13567880
8INSRR3.13368242
9TLK13.12378309
10MAP2K22.93459606
11PTK62.75794763
12BCKDK2.58973369
13PASK2.50467006
14PRKD32.47018337
15RIPK12.45203327
16LATS12.33844726
17MUSK2.20918164
18ICK2.14956665
19TAOK31.98588044
20MAP3K21.90793091
21PDGFRA1.73479259
22GRK61.71510463
23MAP2K61.66261559
24RPS6KB21.64890543
25EPHB11.64887499
26CDK91.63836315
27FRK1.61176697
28BRD41.59652210
29PKN21.58028230
30ACVR1B1.53940335
31FER1.45167310
32PTK21.44594652
33WNK11.40797168
34EPHA21.37326287
35DYRK1B1.33576410
36TESK21.31985986
37TESK11.24881869
38PIK3CA1.23348773
39MAP3K101.23345450
40DAPK21.15920131
41FGFR41.14870930
42MTOR1.10910830
43CDC42BPA1.10764121
44SMG11.08762231
45FLT31.07933517
46SIK11.06593478
47MET1.03287139
48PDK40.99893181
49PDK30.99893181
50MYLK0.95147906
51CDK70.92350581
52LMTK20.91161736
53NME10.90933213
54CSK0.89533360
55PRKD20.88848167
56PAK20.86980014
57BLK0.86915295
58DDR20.86258781
59STK38L0.86142468
60STK30.84827094
61HIPK20.82739452
62MAP3K10.82126075
63PIK3CG0.79652582
64MAP3K30.78814525
65PAK40.76159114
66SCYL20.75172195
67ZAP700.73354463
68MST1R0.72554387
69EEF2K0.69106689
70OXSR10.68944865
71MAPK110.68761263
72NUAK10.68625661
73AKT30.64216606
74GSK3A0.64098423
75PDGFRB0.62321338
76ADRBK20.61580788
77PRKD10.60875231
78NEK60.59018408
79CHUK0.57766983
80ERBB20.57175037
81IRAK20.57154526
82PRKG20.56396732
83SIK20.54826701
84MAP2K10.53731331
85MAPKAPK30.53664587
86ADRBK10.51373399
87RET0.50411103
88CSNK1A1L0.49829618
89MAP3K40.49102073
90TBK10.48963422
91PTK2B0.48927380
92GRK10.47680607
93PAK30.45809228
94CDK40.43641139
95TNK20.42768430
96MAPK80.41977981
97STK380.41657196
98PHKG10.39615725
99PHKG20.39615725
100MARK20.38058739
101MAP3K60.36852553
102RPS6KA20.36401045
103MAPK30.34839515
104MATK0.34803893
105MAP3K70.34346085
106CAMK1D0.33584782
107NTRK10.33342096
108TAOK10.32487513
109PDK20.31968989
110RPS6KA60.31179246
111EPHA30.30784462
112PRKCI0.30753672
113EPHB20.30111032
114NEK20.28858318
115PRKCZ0.28790651
116MAP2K40.28347017
117BMPR1B0.28220387
118MAPK10.28204101
119STK390.28177603
120BMX0.28132933
121PRKACG0.28069055
122MAPKAPK20.28010033
123MAPK120.27745919
124EGFR0.27444278
125PDPK10.27268812
126MELK0.26959128
127DMPK0.26484636
128CAMKK10.25854607
129CDK60.25719873
130MST40.24990964
131JAK20.24709175
132MAPKAPK50.24308636
133CAMK1G0.24220335
134PRKCH0.24069610
135RPS6KC10.23853268
136RPS6KL10.23853268
137PRKAA20.23708113
138PRKAA10.23515339
139IKBKB0.22811304
140DYRK1A0.22674735
141CAMK2G0.22553639
142PRKDC0.21680671
143CSNK1D0.21491849
144ILK0.20778477
145NEK90.19303986
146IRAK30.18767228
147FGFR10.18515839
148RPS6KA10.18227474
149BRAF0.17997617

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.48515666
2Sulfur metabolism_Homo sapiens_hsa009203.13612639
3Fat digestion and absorption_Homo sapiens_hsa049753.12083938
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60724712
5Vitamin digestion and absorption_Homo sapiens_hsa049772.51544051
6Protein export_Homo sapiens_hsa030602.45174663
7Fatty acid degradation_Homo sapiens_hsa000712.30062621
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.21364157
9Selenocompound metabolism_Homo sapiens_hsa004502.15748612
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14531337
11Tryptophan metabolism_Homo sapiens_hsa003802.13270404
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07849833
13Protein digestion and absorption_Homo sapiens_hsa049742.00671178
14Fatty acid metabolism_Homo sapiens_hsa012121.86565584
15Pancreatic secretion_Homo sapiens_hsa049721.86001468
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82064622
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.77295544
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69727814
19Histidine metabolism_Homo sapiens_hsa003401.67176280
20Lysine degradation_Homo sapiens_hsa003101.65229825
21Folate biosynthesis_Homo sapiens_hsa007901.54675424
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50493846
23Pyruvate metabolism_Homo sapiens_hsa006201.49880322
24PPAR signaling pathway_Homo sapiens_hsa033201.49432883
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48083468
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47894847
27Chemical carcinogenesis_Homo sapiens_hsa052041.45728513
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43544261
29Nitrogen metabolism_Homo sapiens_hsa009101.39761857
30Propanoate metabolism_Homo sapiens_hsa006401.39283993
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38747067
32Butanoate metabolism_Homo sapiens_hsa006501.38027548
33Complement and coagulation cascades_Homo sapiens_hsa046101.37514695
34ABC transporters_Homo sapiens_hsa020101.37447195
35Glycerolipid metabolism_Homo sapiens_hsa005611.36276950
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35839775
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34393127
38Bile secretion_Homo sapiens_hsa049761.34133742
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34099356
40Starch and sucrose metabolism_Homo sapiens_hsa005001.31163080
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26975609
42Other glycan degradation_Homo sapiens_hsa005111.26145520
43Mineral absorption_Homo sapiens_hsa049781.24693309
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.22414238
45Fatty acid elongation_Homo sapiens_hsa000621.19789109
46Retinol metabolism_Homo sapiens_hsa008301.13172627
47Linoleic acid metabolism_Homo sapiens_hsa005911.11883913
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08885283
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02098323
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00609801
51beta-Alanine metabolism_Homo sapiens_hsa004100.99131100
52N-Glycan biosynthesis_Homo sapiens_hsa005100.96359328
53Arachidonic acid metabolism_Homo sapiens_hsa005900.95165429
54Circadian rhythm_Homo sapiens_hsa047100.92422427
55Fatty acid biosynthesis_Homo sapiens_hsa000610.92402213
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88971960
57Arginine biosynthesis_Homo sapiens_hsa002200.84486597
58Peroxisome_Homo sapiens_hsa041460.84102809
59Insulin resistance_Homo sapiens_hsa049310.83923469
60Insulin secretion_Homo sapiens_hsa049110.83740195
61Dorso-ventral axis formation_Homo sapiens_hsa043200.83283009
62Taste transduction_Homo sapiens_hsa047420.83174319
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72890260
64Ether lipid metabolism_Homo sapiens_hsa005650.71128288
65Glutathione metabolism_Homo sapiens_hsa004800.68745528
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68445228
67Renin-angiotensin system_Homo sapiens_hsa046140.67851260
68Arginine and proline metabolism_Homo sapiens_hsa003300.66300964
69Phenylalanine metabolism_Homo sapiens_hsa003600.66214914
70Sulfur relay system_Homo sapiens_hsa041220.63801974
71ECM-receptor interaction_Homo sapiens_hsa045120.63645828
72Notch signaling pathway_Homo sapiens_hsa043300.61408562
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.60534329
74Amoebiasis_Homo sapiens_hsa051460.59956542
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.59462072
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59081901
77Hepatitis C_Homo sapiens_hsa051600.57995988
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56035865
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55248734
80Galactose metabolism_Homo sapiens_hsa000520.53604620
81Thyroid hormone synthesis_Homo sapiens_hsa049180.52190032
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52039950
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.52014036
84Ovarian steroidogenesis_Homo sapiens_hsa049130.51467298
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.49553071
86Lysosome_Homo sapiens_hsa041420.48706335
87Type II diabetes mellitus_Homo sapiens_hsa049300.48467163
88Small cell lung cancer_Homo sapiens_hsa052220.46189443
89Tight junction_Homo sapiens_hsa045300.46179589
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45603076
91Tyrosine metabolism_Homo sapiens_hsa003500.45383261
92Glucagon signaling pathway_Homo sapiens_hsa049220.44143235
93Caffeine metabolism_Homo sapiens_hsa002320.43920601
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43794576
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43785813
96Vitamin B6 metabolism_Homo sapiens_hsa007500.42815925
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42595621
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.39734630
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38923070
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38399962
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38220125
102Hedgehog signaling pathway_Homo sapiens_hsa043400.37613732
103Bladder cancer_Homo sapiens_hsa052190.36602406
104Prolactin signaling pathway_Homo sapiens_hsa049170.35138378
105mTOR signaling pathway_Homo sapiens_hsa041500.34192674
106Carbon metabolism_Homo sapiens_hsa012000.33884968
107TGF-beta signaling pathway_Homo sapiens_hsa043500.33766015
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33666582
109Vibrio cholerae infection_Homo sapiens_hsa051100.33662513
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33237460
111AMPK signaling pathway_Homo sapiens_hsa041520.32685617
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31905902
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31817981
114Thyroid cancer_Homo sapiens_hsa052160.31369882
115Biosynthesis of amino acids_Homo sapiens_hsa012300.30621667
116Hippo signaling pathway_Homo sapiens_hsa043900.30011363
117Prion diseases_Homo sapiens_hsa050200.29512935
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.28487132
119Sphingolipid metabolism_Homo sapiens_hsa006000.28128191
120Fanconi anemia pathway_Homo sapiens_hsa034600.27444948
121Fructose and mannose metabolism_Homo sapiens_hsa000510.26825071
122VEGF signaling pathway_Homo sapiens_hsa043700.26549139
123Metabolic pathways_Homo sapiens_hsa011000.26247931
124Inositol phosphate metabolism_Homo sapiens_hsa005620.26147079
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23635685
126Insulin signaling pathway_Homo sapiens_hsa049100.22895545
127Cocaine addiction_Homo sapiens_hsa050300.21580640

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