ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of activin receptor signaling pathway (GO:0032926)	8.30465427
2	short-term memory (GO:0007614)	7.99549753
3	glucocorticoid receptor signaling pathway (GO:0042921)	7.79205616
4	protein insertion into membrane (GO:0051205)	7.63061393
5	negative regulation of amino acid transport (GO:0051956)	6.86439143
6	corticosteroid receptor signaling pathway (GO:0031958)	6.15439239
7	protoporphyrinogen IX metabolic process (GO:0046501)	5.99681056
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.82238479
9	NADH dehydrogenase complex assembly (GO:0010257)	5.82238479
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.82238479
11	cytokine production involved in immune response (GO:0002367)	5.65729673
12	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	5.51482788
13	negative regulation of appetite (GO:0032099)	5.44012909
14	negative regulation of response to food (GO:0032096)	5.44012909
15	regulation of glutamate secretion (GO:0014048)	5.42783416
16	cellular response to nerve growth factor stimulus (GO:1990090)	5.30274244
17	response to nerve growth factor (GO:1990089)	5.30274244
18	dopaminergic neuron differentiation (GO:0071542)	5.22334297
19	protoporphyrinogen IX biosynthetic process (GO:0006782)	5.09636061
20	transmission of nerve impulse (GO:0019226)	5.05974263
21	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	4.84474893
22	nerve growth factor signaling pathway (GO:0038180)	4.81354177
23	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.75592095
24	regulation of collateral sprouting (GO:0048670)	4.72588036
25	regulation of glycogen (starch) synthase activity (GO:2000465)	4.64061406
26	protein complex biogenesis (GO:0070271)	4.63885603
27	lipopolysaccharide biosynthetic process (GO:0009103)	4.61088634
28	glomerular visceral epithelial cell development (GO:0072015)	4.39300011
29	vitamin transmembrane transport (GO:0035461)	4.37755625
30	heme biosynthetic process (GO:0006783)	4.33674103
31	chaperone-mediated protein transport (GO:0072321)	4.25936387
32	behavioral response to nicotine (GO:0035095)	4.17318490
33	regulation of sequestering of triglyceride (GO:0010889)	4.13005131
34	mitochondrial respiratory chain complex assembly (GO:0033108)	4.09660648
35	V(D)J recombination (GO:0033151)	4.05160278
36	lipopolysaccharide metabolic process (GO:0008653)	3.99626720
37	myeloid leukocyte mediated immunity (GO:0002444)	3.98419316
38	regulation of response to food (GO:0032095)	3.91800796
39	positive regulation of neuroblast proliferation (GO:0002052)	3.83630301
40	glomerular epithelial cell development (GO:0072310)	3.83278935
41	inner mitochondrial membrane organization (GO:0007007)	3.83115969
42	membrane depolarization during action potential (GO:0086010)	3.80729665
43	mitotic cell cycle arrest (GO:0071850)	3.79224760
44	tooth mineralization (GO:0034505)	3.77186827
45	protein localization to cilium (GO:0061512)	3.66471664
46	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.66223209
47	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.60263547
48	response to insecticide (GO:0017085)	3.56705819
49	regulation of cholesterol storage (GO:0010885)	3.56501839
50	intracellular estrogen receptor signaling pathway (GO:0030520)	3.54947547
51	leukotriene biosynthetic process (GO:0019370)	3.54404960
52	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.53235640
53	heme metabolic process (GO:0042168)	3.51468354
54	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.49118568
55	myeloid dendritic cell differentiation (GO:0043011)	3.43870299
56	sleep (GO:0030431)	3.43595544
57	regulation of amino acid transport (GO:0051955)	3.42047773
58	regulation of appetite (GO:0032098)	3.39572322
59	regulation of activin receptor signaling pathway (GO:0032925)	3.39072503
60	protein heterotetramerization (GO:0051290)	3.36022251
61	gonadal mesoderm development (GO:0007506)	3.33294942
62	porphyrin-containing compound biosynthetic process (GO:0006779)	3.31834875
63	negative regulation of oxidoreductase activity (GO:0051354)	3.29100924
64	myeloid dendritic cell activation (GO:0001773)	3.28537362
65	negative regulation of lipid storage (GO:0010888)	3.25674566
66	atrial cardiac muscle cell action potential (GO:0086014)	3.24614250
67	production of molecular mediator of immune response (GO:0002440)	3.21391370
68	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20896514
69	positive regulation of gluconeogenesis (GO:0045722)	3.17591073
70	negative regulation of protein localization to cell surface (GO:2000009)	3.14140254
71	regulation of cilium movement (GO:0003352)	3.12634541
72	DNA deamination (GO:0045006)	3.12407242
73	signal peptide processing (GO:0006465)	3.09838199
74	tetrapyrrole biosynthetic process (GO:0033014)	3.08398197
75	positive regulation of protein export from nucleus (GO:0046827)	3.06787879
76	SMAD protein signal transduction (GO:0060395)	3.05760673
77	olfactory bulb development (GO:0021772)	3.03288051
78	L-serine transport (GO:0015825)	3.03083658
79	porphyrin-containing compound metabolic process (GO:0006778)	3.01282383
80	transepithelial transport (GO:0070633)	2.98771280
81	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.98227164
82	glutamate receptor signaling pathway (GO:0007215)	2.97906052
83	negative regulation of response to nutrient levels (GO:0032108)	2.96635372
84	negative regulation of response to extracellular stimulus (GO:0032105)	2.96635372
85	neuron fate specification (GO:0048665)	2.95667347
86	regulation of coenzyme metabolic process (GO:0051196)	2.94484332
87	regulation of cofactor metabolic process (GO:0051193)	2.94484332
88	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.94034682
89	aerobic respiration (GO:0009060)	2.93208101
90	regulation of T cell differentiation in thymus (GO:0033081)	2.91463360
91	cellular respiration (GO:0045333)	2.90964175
92	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.85516873
93	C4-dicarboxylate transport (GO:0015740)	2.83583227
94	negative regulation of amine transport (GO:0051953)	2.82048965
95	T cell lineage commitment (GO:0002360)	2.75720585
96	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.74697363
97	somatic diversification of immune receptors (GO:0002200)	2.73464539
98	multicellular organismal signaling (GO:0035637)	2.71143104
99	somatic cell DNA recombination (GO:0016444)	2.69252818
100	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.69252818

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.62768189
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.31228502
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.06963580
4	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.30529129
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.68441900
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.65569587
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.63790953
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.61049012
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.46610454
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43700182
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.31828839
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.06256982
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.89617458
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.87685230
15	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.85233222
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.84458473
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81684270
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71547628
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70101176
20	P300_19829295_ChIP-Seq_ESCs_Human	1.68852630
21	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.67699693
22	FUS_26573619_Chip-Seq_HEK293_Human	1.66513138
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.60761377
24	REST_21632747_ChIP-Seq_MESCs_Mouse	1.59709756
25	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.58275210
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.52346271
27	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.52169488
28	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.50346399
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.48682700
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.47180986
31	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.46669162
32	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.44766208
33	P300_18555785_Chip-Seq_ESCs_Mouse	1.42974006
34	JUN_21703547_ChIP-Seq_K562_Human	1.42638569
35	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.40893214
36	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.40877280
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.40747457
38	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.40543546
39	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.39436275
40	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39275404
41	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.39053898
42	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.37253588
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33806544
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.33806544
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.32570109
46	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.31828400
47	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.31078088
48	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.30297902
49	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.30194708
50	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.30009203
51	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29637144
52	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27825411
53	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.26771544
54	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.25567276
55	AR_25329375_ChIP-Seq_VCAP_Human	1.24626821
56	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.22046428
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21032686
58	PU1_27457419_Chip-Seq_LIVER_Mouse	1.20961500
59	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20664640
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20512240
61	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.20369675
62	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.19531229
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19451455
64	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.18911416
65	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18883875
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18822540
67	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15729604
68	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12982075
69	EWS_26573619_Chip-Seq_HEK293_Human	1.12917144
70	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.12671705
71	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.12283011
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11313080
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10964661
74	BCAT_22108803_ChIP-Seq_LS180_Human	1.09825514
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09370729
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08319072
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07848496
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06444461
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06197247
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05796820
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05796820
82	ELK1_19687146_ChIP-ChIP_HELA_Human	1.05643912
83	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05330473
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05315814
85	GATA3_26560356_Chip-Seq_TH1_Human	1.04907380
86	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.04442225
87	TP53_22573176_ChIP-Seq_HFKS_Human	1.04305864
88	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.04304075
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.04205589
90	VDR_22108803_ChIP-Seq_LS180_Human	1.02490456
91	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.02072382
92	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01501618
93	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00956630
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.00907221
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99691722
96	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99423196
97	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99423196
98	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98951723
99	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98846541
100	GATA3_27048872_Chip-Seq_THYMUS_Human	0.98701373

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	6.90518657
2	MP0004264_abnormal_extraembryonic_tissu	4.82251516
3	MP0004147_increased_porphyrin_level	3.92330220
4	MP0005423_abnormal_somatic_nervous	3.84870808
5	MP0003567_abnormal_fetal_cardiomyocyte	3.81305230
6	MP0004145_abnormal_muscle_electrophysio	3.59954646
7	MP0003868_abnormal_feces_composition	3.33737271
8	MP0004130_abnormal_muscle_cell	3.18064591
9	MP0002736_abnormal_nociception_after	3.10611392
10	MP0004510_myositis	2.73228390
11	MP0005365_abnormal_bile_salt	2.69166944
12	MP0002876_abnormal_thyroid_physiology	2.67481063
13	MP0003880_abnormal_central_pattern	2.66374769
14	MP0002909_abnormal_adrenal_gland	2.37418602
15	MP0001968_abnormal_touch/_nociception	2.32178268
16	MP0005671_abnormal_response_to	2.17732568
17	MP0003656_abnormal_erythrocyte_physiolo	2.11399833
18	MP0001919_abnormal_reproductive_system	2.08363856
19	MP0002064_seizures	1.99908075
20	MP0002160_abnormal_reproductive_system	1.90446004
21	MP0003011_delayed_dark_adaptation	1.90123636
22	MP0009278_abnormal_bone_marrow	1.89842255
23	MP0005310_abnormal_salivary_gland	1.80523320
24	MP0001853_heart_inflammation	1.79043061
25	MP0005075_abnormal_melanosome_morpholog	1.78806852
26	MP0005551_abnormal_eye_electrophysiolog	1.70486109
27	MP0005379_endocrine/exocrine_gland_phen	1.67973138
28	MP0009046_muscle_twitch	1.65559078
29	MP0003045_fibrosis	1.60921632
30	MP0005023_abnormal_wound_healing	1.50878650
31	MP0001188_hyperpigmentation	1.45961004
32	MP0002272_abnormal_nervous_system	1.44854157
33	MP0000013_abnormal_adipose_tissue	1.44123512
34	MP0005670_abnormal_white_adipose	1.41196311
35	MP0009765_abnormal_xenobiotic_induced	1.41025759
36	MP0001529_abnormal_vocalization	1.40647550
37	MP0009745_abnormal_behavioral_response	1.40235539
38	MP0005389_reproductive_system_phenotype	1.33222633
39	MP0004885_abnormal_endolymph	1.31021775
40	MP0001881_abnormal_mammary_gland	1.28927152
41	MP0002184_abnormal_innervation	1.28437671
42	MP0000647_abnormal_sebaceous_gland	1.21928726
43	MP0004215_abnormal_myocardial_fiber	1.20758772
44	MP0003635_abnormal_synaptic_transmissio	1.19987343
45	MP0001970_abnormal_pain_threshold	1.19354097
46	MP0001905_abnormal_dopamine_level	1.19183459
47	MP0002733_abnormal_thermal_nociception	1.17450079
48	MP0003195_calcinosis	1.16537590
49	MP0001324_abnormal_eye_pigmentation	1.14442569
50	MP0002572_abnormal_emotion/affect_behav	1.14291769
51	MP0000372_irregular_coat_pigmentation	1.13758222
52	MP0003724_increased_susceptibility_to	1.12561364
53	MP0002067_abnormal_sensory_capabilities	1.11554487
54	MP0003806_abnormal_nucleotide_metabolis	1.10506524
55	MP0002106_abnormal_muscle_physiology	1.09281179
56	MP0002735_abnormal_chemical_nociception	1.04352620
57	MP0005410_abnormal_fertilization	1.03975884
58	MP0001542_abnormal_bone_strength	0.97966923
59	MP0004924_abnormal_behavior	0.92156016
60	MP0005386_behavior/neurological_phenoty	0.92156016
61	MP0001486_abnormal_startle_reflex	0.88719213
62	MP0002653_abnormal_ependyma_morphology	0.87356020
63	MP0005084_abnormal_gallbladder_morpholo	0.85770118
64	MP0010329_abnormal_lipoprotein_level	0.84686726
65	MP0005369_muscle_phenotype	0.82378973
66	MP0003646_muscle_fatigue	0.81404948
67	MP0002063_abnormal_learning/memory/cond	0.81141701
68	MP0006072_abnormal_retinal_apoptosis	0.77691510
69	MP0001984_abnormal_olfaction	0.76375593
70	MP0002102_abnormal_ear_morphology	0.76226314
71	MP0000230_abnormal_systemic_arterial	0.75902750
72	MP0009785_altered_susceptibility_to	0.75519832
73	MP0005253_abnormal_eye_physiology	0.74810106
74	MP0010386_abnormal_urinary_bladder	0.72986223
75	MP0004142_abnormal_muscle_tone	0.71347597
76	MP0009763_increased_sensitivity_to	0.70142696
77	MP0005645_abnormal_hypothalamus_physiol	0.67610509
78	MP0003763_abnormal_thymus_physiology	0.67456179
79	MP0001661_extended_life_span	0.66975550
80	MP0001544_abnormal_cardiovascular_syste	0.66510149
81	MP0005385_cardiovascular_system_phenoty	0.66510149
82	MP0001790_abnormal_immune_system	0.66359544
83	MP0005387_immune_system_phenotype	0.66359544
84	MP0010094_abnormal_chromosome_stability	0.64456008
85	MP0008995_early_reproductive_senescence	0.64079048
86	MP0002148_abnormal_hypersensitivity_rea	0.62590185
87	MP0010352_gastrointestinal_tract_polyps	0.60506283
88	MP0002405_respiratory_system_inflammati	0.60370875
89	MP0000462_abnormal_digestive_system	0.58671701
90	MP0000639_abnormal_adrenal_gland	0.56084934
91	MP0005397_hematopoietic_system_phenotyp	0.55050330
92	MP0001545_abnormal_hematopoietic_system	0.55050330
93	MP0005503_abnormal_tendon_morphology	0.53945661
94	MP0005174_abnormal_tail_pigmentation	0.53491467
95	MP0004185_abnormal_adipocyte_glucose	0.49840565
96	MP0005535_abnormal_body_temperature	0.48182072
97	MP0006276_abnormal_autonomic_nervous	0.47766221
98	MP0003693_abnormal_embryo_hatching	0.47527681
99	MP0000955_abnormal_spinal_cord	0.45530595
100	MP0002882_abnormal_neuron_morphology	0.45004398

Predicted human phenotypes

Rank	Gene Set	Z-score
1	B lymphocytopenia (HP:0010976)	6.09204030
2	Eosinophilia (HP:0001880)	5.51115436
3	Severe combined immunodeficiency (HP:0004430)	5.50150431
4	Abnormality of B cell number (HP:0010975)	5.34269293
5	Abnormality of eosinophils (HP:0001879)	4.72561123
6	Thyroiditis (HP:0100646)	4.49558802
7	Granulocytopenia (HP:0001913)	4.43201273
8	Absent/shortened dynein arms (HP:0200106)	4.32348359
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.32348359
10	Combined immunodeficiency (HP:0005387)	4.22002515
11	T lymphocytopenia (HP:0005403)	3.89153387
12	Agitation (HP:0000713)	3.75029384
13	Hypoproteinemia (HP:0003075)	3.63149076
14	Hypoplasia of the thymus (HP:0000778)	3.59783153
15	Chronic otitis media (HP:0000389)	3.56415057
16	Panhypogammaglobulinemia (HP:0003139)	3.46369992
17	Short tibia (HP:0005736)	3.37270487
18	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.35803037
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.24903212
20	Abnormality of T cell number (HP:0011839)	3.22234661
21	Erythroderma (HP:0001019)	3.22123092
22	IgG deficiency (HP:0004315)	3.13785821
23	Confusion (HP:0001289)	3.11356571
24	Progressive cerebellar ataxia (HP:0002073)	3.10102289
25	3-Methylglutaconic aciduria (HP:0003535)	3.03522548
26	Limb dystonia (HP:0002451)	2.99082392
27	Bony spicule pigmentary retinopathy (HP:0007737)	2.95472230
28	Increased corneal curvature (HP:0100692)	2.92827491
29	Keratoconus (HP:0000563)	2.92827491
30	Neoplasm of head and neck (HP:0012288)	2.81318067
31	Esophageal neoplasm (HP:0100751)	2.81318067
32	Menstrual irregularities (HP:0000858)	2.80029811
33	Leukocytosis (HP:0001974)	2.78759042
34	Abolished electroretinogram (ERG) (HP:0000550)	2.77318372
35	Papillary thyroid carcinoma (HP:0002895)	2.70342742
36	Restlessness (HP:0000711)	2.66433960
37	Congenital stationary night blindness (HP:0007642)	2.56441682
38	Facial diplegia (HP:0001349)	2.56116610
39	Abnormal respiratory epithelium morphology (HP:0012253)	2.49305891
40	Abnormal respiratory motile cilium morphology (HP:0005938)	2.49305891
41	Supernumerary spleens (HP:0009799)	2.46440633
42	Chronic sinusitis (HP:0011109)	2.46431758
43	Decreased subcutaneous fat (HP:0001002)	2.45559631
44	Impulsivity (HP:0100710)	2.45104671
45	Congenital, generalized hypertrichosis (HP:0004540)	2.42288241
46	Abnormal ciliary motility (HP:0012262)	2.39743506
47	Recurrent viral infections (HP:0004429)	2.30222888
48	Action tremor (HP:0002345)	2.29231238
49	Decreased central vision (HP:0007663)	2.28485065
50	Renal Fanconi syndrome (HP:0001994)	2.28197708
51	Vertebral compression fractures (HP:0002953)	2.25152955
52	Hepatocellular necrosis (HP:0001404)	2.24273037
53	Increased IgE level (HP:0003212)	2.24123211
54	Oligomenorrhea (HP:0000876)	2.23814862
55	Hypothermia (HP:0002045)	2.22509185
56	Joint swelling (HP:0001386)	2.22027836
57	Methylmalonic acidemia (HP:0002912)	2.19508752
58	Gait imbalance (HP:0002141)	2.13222132
59	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.08317464
60	Congenital primary aphakia (HP:0007707)	2.07945526
61	Dialeptic seizures (HP:0011146)	2.07811103
62	Abnormality of methionine metabolism (HP:0010901)	2.06898400
63	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.04209486
64	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.04209486
65	Mitochondrial inheritance (HP:0001427)	2.02555904
66	Genetic anticipation (HP:0003743)	2.01102683
67	Concave nail (HP:0001598)	1.98831316
68	Vacuolated lymphocytes (HP:0001922)	1.97477260
69	Increased muscle lipid content (HP:0009058)	1.95140248
70	Delusions (HP:0000746)	1.91839819
71	Recurrent fungal infections (HP:0002841)	1.91369685
72	Methylmalonic aciduria (HP:0012120)	1.88483479
73	Opisthotonus (HP:0002179)	1.88055911
74	Aplasia/Hypoplasia of the lens (HP:0008063)	1.87287626
75	Glucose intolerance (HP:0000833)	1.86357757
76	Broad ribs (HP:0000885)	1.82809517
77	Hepatic necrosis (HP:0002605)	1.82385837
78	Inability to walk (HP:0002540)	1.80508804
79	Thyroid carcinoma (HP:0002890)	1.80316045
80	Disinhibition (HP:0000734)	1.79626779
81	Hypochromic microcytic anemia (HP:0004840)	1.79432613
82	Horseshoe kidney (HP:0000085)	1.79183568
83	Hyperalaninemia (HP:0003348)	1.77274562
84	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.77274562
85	Abnormality of alanine metabolism (HP:0010916)	1.77274562
86	Increased CSF lactate (HP:0002490)	1.75636317
87	Fused cervical vertebrae (HP:0002949)	1.74039899
88	Increased intramyocellular lipid droplets (HP:0012240)	1.73249645
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73149551
90	Abnormality of dental color (HP:0011073)	1.72196058
91	Nephrogenic diabetes insipidus (HP:0009806)	1.71412419
92	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.71193211
93	Abnormality of T cells (HP:0002843)	1.69332015
94	Pruritus (HP:0000989)	1.68797311
95	Bifid tongue (HP:0010297)	1.67442787
96	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.66526738
97	Medial flaring of the eyebrow (HP:0010747)	1.65393746
98	Hypoalphalipoproteinemia (HP:0003233)	1.64570166
99	Male infertility (HP:0003251)	1.63791693
100	Inappropriate behavior (HP:0000719)	1.62980190

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.84197603
2	CAMKK1	4.54433748
3	EIF2AK1	3.92140037
4	MAPK13	2.51703462
5	EPHA3	2.35966048
6	TLK1	2.27511793
7	CAMKK2	10.1125409
8	CAMK4	1.94785394
9	TYRO3	1.60875834
10	WNK3	1.53903101
11	SIK2	1.53356050
12	CAMK1	1.47978901
13	ZAK	1.46212245
14	FGR	1.44376184
15	KDR	1.34824064
16	TRIM28	1.26981502
17	MAP4K2	1.19566323
18	FRK	1.17988371
19	TESK2	1.17186798
20	TAF1	1.15164626
21	NLK	1.09841313
22	BCKDK	1.03905562
23	SRPK1	0.95420569
24	ALK	0.91218166
25	GRK1	0.90174401
26	WNK4	0.90082006
27	RPS6KA5	0.89719198
28	SGK2	0.87077912
29	VRK1	0.86211862
30	MAP3K12	0.77378986
31	GRK5	0.76486360
32	PAK3	0.75922079
33	BLK	0.73873949
34	SGK494	0.73692084
35	SGK223	0.73692084
36	DYRK2	0.70828270
37	EPHB1	0.70458592
38	TXK	0.69508102
39	ITK	0.69117789
40	TESK1	0.68651064
41	ERBB3	0.67089120
42	KIT	0.65768539
43	SIK3	0.64615639
44	JAK3	0.62203124
45	CLK1	0.62090479
46	MAPK4	0.60540762
47	CAMK2A	0.57750725
48	RPS6KA4	0.53663841
49	MAP3K10	0.53487374
50	PIK3CG	0.51623027
51	MAP4K1	0.50888465
52	FYN	0.50797435
53	MAP3K7	0.49627784
54	DYRK3	0.49525152
55	FGFR4	0.46331532
56	PKN1	0.45909219
57	PINK1	0.44606090
58	MARK3	0.44084213
59	LCK	0.43258291
60	BUB1	0.43246105
61	HIPK2	0.42250675
62	SYK	0.41144731
63	PRKACA	0.40732795
64	JAK1	0.40235032
65	CDK14	0.39401669
66	PTK2B	0.38040201
67	IRAK1	0.38024757
68	CAMK2B	0.36831074
69	MAPKAPK5	0.36248847
70	MKNK2	0.35264992
71	TEC	0.34333993
72	BRSK2	0.34096834
73	MINK1	0.33919845
74	ADRBK2	0.32299100
75	FER	0.32150935
76	CDK18	0.31621508
77	NTRK2	0.31443869
78	PRKD2	0.31056873
79	CDK5	0.30467937
80	STK4	0.30311919
81	ADRBK1	0.28651379
82	CDK15	0.28309249
83	PRKCB	0.28210784
84	LIMK1	0.27471791
85	SGK3	0.25997465
86	CSNK1G3	0.25516149
87	MATK	0.24409667
88	MAP3K11	0.24378550
89	STK39	0.24031142
90	PRKCD	0.23853188
91	IRAK4	0.23675628
92	CDK11A	0.22495056
93	PRKCZ	0.21959314
94	OXSR1	0.21667208
95	TTK	0.20877807
96	LYN	0.20842122
97	IKBKE	0.20171467
98	MAP2K2	0.19999529
99	PRKCA	0.19360702
100	CSNK1A1	0.18585684

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	7.41136647
2	Regulation of autophagy_Homo sapiens_hsa04140	4.34173048
3	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.65656894
4	Phototransduction_Homo sapiens_hsa04744	2.51731061
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.37386162
6	Basal transcription factors_Homo sapiens_hsa03022	2.35875726
7	Proteasome_Homo sapiens_hsa03050	2.30381009
8	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.96329097
9	Ether lipid metabolism_Homo sapiens_hsa00565	1.95660118
10	Oxidative phosphorylation_Homo sapiens_hsa00190	1.93776586
11	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.90104816
12	Amphetamine addiction_Homo sapiens_hsa05031	1.89685151
13	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.84238413
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.75647689
15	Alcoholism_Homo sapiens_hsa05034	1.71870079
16	Parkinsons disease_Homo sapiens_hsa05012	1.58296059
17	Nicotine addiction_Homo sapiens_hsa05033	1.56921077
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55012072
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.53527658
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.42626961
21	Sulfur relay system_Homo sapiens_hsa04122	1.33249070
22	Alzheimers disease_Homo sapiens_hsa05010	1.31857594
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.26225167
24	Sulfur metabolism_Homo sapiens_hsa00920	1.21168493
25	Glutamatergic synapse_Homo sapiens_hsa04724	1.20724595
26	Olfactory transduction_Homo sapiens_hsa04740	1.19850359
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.17113005
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15459005
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.13153029
30	Long-term potentiation_Homo sapiens_hsa04720	1.12619188
31	Huntingtons disease_Homo sapiens_hsa05016	1.09737166
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.08598094
33	RNA polymerase_Homo sapiens_hsa03020	1.06291765
34	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.06076808
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.00854624
36	Graft-versus-host disease_Homo sapiens_hsa05332	1.00647712
37	Taste transduction_Homo sapiens_hsa04742	0.99174724
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.93880351
39	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.90790506
40	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.86229389
41	RNA degradation_Homo sapiens_hsa03018	0.83217688
42	Allograft rejection_Homo sapiens_hsa05330	0.82592570
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80729661
44	Oocyte meiosis_Homo sapiens_hsa04114	0.77851000
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.77397898
46	Cocaine addiction_Homo sapiens_hsa05030	0.73730430
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73670827
48	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.73313131
49	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.73147055
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.72577955
51	Folate biosynthesis_Homo sapiens_hsa00790	0.71509576
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.69835967
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.66426504
54	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.66401407
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.65589306
56	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64165183
57	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63089658
58	Homologous recombination_Homo sapiens_hsa03440	0.62640590
59	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.62122374
60	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.61707462
61	GABAergic synapse_Homo sapiens_hsa04727	0.61463889
62	Serotonergic synapse_Homo sapiens_hsa04726	0.61225710
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.61222419
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59211139
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58883679
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.58430450
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.57000349
68	Morphine addiction_Homo sapiens_hsa05032	0.56855100
69	Axon guidance_Homo sapiens_hsa04360	0.56853129
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54307080
71	Ras signaling pathway_Homo sapiens_hsa04014	0.53851863
72	Viral carcinogenesis_Homo sapiens_hsa05203	0.51865308
73	Viral myocarditis_Homo sapiens_hsa05416	0.49643625
74	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.45308325
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.45218220
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44722878
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43893401
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.43383702
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43027222
80	Phagosome_Homo sapiens_hsa04145	0.42639479
81	Malaria_Homo sapiens_hsa05144	0.40743969
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40278588
83	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.37903289
84	Rap1 signaling pathway_Homo sapiens_hsa04015	0.36889494
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.35872689
86	Renin secretion_Homo sapiens_hsa04924	0.35445972
87	Circadian entrainment_Homo sapiens_hsa04713	0.34119279
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32308797
89	Cholinergic synapse_Homo sapiens_hsa04725	0.31573713
90	Renin-angiotensin system_Homo sapiens_hsa04614	0.31559868
91	Long-term depression_Homo sapiens_hsa04730	0.30520414
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.28501399
93	Butanoate metabolism_Homo sapiens_hsa00650	0.27776078
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.27156086
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.27002770
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.24312965
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.22988940
98	Histidine metabolism_Homo sapiens_hsa00340	0.22472137
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.21245529
100	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.20158913

TMEM185AP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »