TMEM185B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71326011
2ribosomal small subunit assembly (GO:0000028)4.27972122
3viral transcription (GO:0019083)4.11011144
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.00751500
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.00751500
6COPI coating of Golgi vesicle (GO:0048205)4.00485718
7Golgi transport vesicle coating (GO:0048200)4.00485718
8translational termination (GO:0006415)3.99119753
9protein localization to endosome (GO:0036010)3.95254337
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83040505
11cotranslational protein targeting to membrane (GO:0006613)3.75591131
12DNA deamination (GO:0045006)3.73581904
13protein targeting to ER (GO:0045047)3.72433777
14hemidesmosome assembly (GO:0031581)3.62375120
15ribosomal small subunit biogenesis (GO:0042274)3.60885535
16skin morphogenesis (GO:0043589)3.58279096
17maturation of SSU-rRNA (GO:0030490)3.57839006
18antigen processing and presentation via MHC class Ib (GO:0002475)3.56318457
19establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55989586
20protein localization to endoplasmic reticulum (GO:0070972)3.52686064
21translational elongation (GO:0006414)3.52122809
22cell adhesion mediated by integrin (GO:0033627)3.41509225
23response to interferon-beta (GO:0035456)3.39575291
24immunoglobulin mediated immune response (GO:0016064)3.36956798
25antigen processing and presentation of endogenous antigen (GO:0019883)3.32627224
26mitotic chromosome condensation (GO:0007076)3.31585862
27positive regulation of gamma-delta T cell activation (GO:0046645)3.30266862
28cell-substrate junction assembly (GO:0007044)3.24482518
29regulation of early endosome to late endosome transport (GO:2000641)3.23591253
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.22310621
31regulation of B cell receptor signaling pathway (GO:0050855)3.20729711
32positive regulation of B cell differentiation (GO:0045579)3.20068310
33DNA strand elongation involved in DNA replication (GO:0006271)3.19247512
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.18033970
35translational initiation (GO:0006413)3.17677877
36regulation of vitamin D biosynthetic process (GO:0060556)3.15676123
37viral life cycle (GO:0019058)3.14969123
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13909550
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.10607985
40mast cell activation (GO:0045576)3.09584638
41lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08253831
42pinocytosis (GO:0006907)3.08162245
43pseudouridine synthesis (GO:0001522)3.07078197
44positive regulation of Cdc42 GTPase activity (GO:0043089)3.06614975
45DNA strand elongation (GO:0022616)3.02254613
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01240071
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.99177138
48B cell mediated immunity (GO:0019724)2.98650059
49positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.97343597
50cell-substrate adherens junction assembly (GO:0007045)2.97157044
51focal adhesion assembly (GO:0048041)2.97157044
52telomere maintenance via semi-conservative replication (GO:0032201)2.96172184
53ribosomal large subunit biogenesis (GO:0042273)2.95336033
54embryonic process involved in female pregnancy (GO:0060136)2.94633885
55regulation of B cell differentiation (GO:0045577)2.94545379
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92552365
57positive regulation by organism of defense response of other organism involved in symbiotic interact2.92552365
58modulation by symbiont of host immune response (GO:0052553)2.92552365
59positive regulation by symbiont of host defense response (GO:0052509)2.92552365
60modulation by symbiont of host defense response (GO:0052031)2.92552365
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92552365
62stress fiber assembly (GO:0043149)2.88436165
63cellular protein complex disassembly (GO:0043624)2.86838532
64epithelial cell differentiation involved in prostate gland development (GO:0060742)2.86220388
65cellular response to interferon-beta (GO:0035458)2.86169008
66adherens junction assembly (GO:0034333)2.85621276
67response to laminar fluid shear stress (GO:0034616)2.85400753
68hypotonic response (GO:0006971)2.85081209
69positive regulation of keratinocyte differentiation (GO:0045618)2.84380939
70NIK/NF-kappaB signaling (GO:0038061)2.79754018
71purine-containing compound salvage (GO:0043101)2.79522752
72respiratory burst (GO:0045730)2.76569503
73negative regulation of interleukin-12 production (GO:0032695)2.74912240
74DNA replication initiation (GO:0006270)2.71881702
75defense response to protozoan (GO:0042832)2.70571082
76activation of Rac GTPase activity (GO:0032863)2.69927216
77regulation of NFAT protein import into nucleus (GO:0051532)2.68119813
78response to protozoan (GO:0001562)2.67988462
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.66312936
80positive regulation of blood vessel endothelial cell migration (GO:0043536)2.65181067
81folic acid-containing compound biosynthetic process (GO:0009396)2.64924148
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64807991
83lymph node development (GO:0048535)2.63999594
84regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63791353
85neutrophil activation involved in immune response (GO:0002283)2.63675574
86modulation by symbiont of host cellular process (GO:0044068)2.63345366
87amyloid precursor protein catabolic process (GO:0042987)2.63311188
88nuclear pore complex assembly (GO:0051292)2.63123083
89response to interferon-alpha (GO:0035455)2.62600101
90regulation of interleukin-12 biosynthetic process (GO:0045075)2.60451880
91regulation of membrane protein ectodomain proteolysis (GO:0051043)2.59489970
92signal peptide processing (GO:0006465)2.59462205
93dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58382763
94membrane protein ectodomain proteolysis (GO:0006509)2.57106010
95leukocyte aggregation (GO:0070486)2.56379514
96regulation of interferon-beta biosynthetic process (GO:0045357)2.55809600
97formation of translation preinitiation complex (GO:0001731)2.55500740
98telomere maintenance via recombination (GO:0000722)2.55285961
99response to type I interferon (GO:0034340)2.55047755
100substrate-dependent cell migration (GO:0006929)2.54818318
101type I interferon signaling pathway (GO:0060337)2.53980934
102cellular response to type I interferon (GO:0071357)2.53980934
103negative regulation of erythrocyte differentiation (GO:0045647)2.53973876
104nuclear-transcribed mRNA catabolic process (GO:0000956)2.53692742
105negative regulation of phagocytosis (GO:0050765)2.52987757
106chaperone mediated protein folding requiring cofactor (GO:0051085)2.52975524
107mammary gland epithelial cell proliferation (GO:0033598)2.52687373
108response to peptidoglycan (GO:0032494)2.52304169
109termination of RNA polymerase III transcription (GO:0006386)2.51644976
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.51644976
111response to muramyl dipeptide (GO:0032495)2.51255639
112negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50828005
113T cell homeostasis (GO:0043029)2.50239449
114trophoblast giant cell differentiation (GO:0060707)2.48917519
115barbed-end actin filament capping (GO:0051016)2.48132685
116macrophage differentiation (GO:0030225)2.47900953
117apoptotic process involved in morphogenesis (GO:0060561)2.47804749
118ribonucleoprotein complex biogenesis (GO:0022613)2.47054311
119regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.46548616
120pentose-phosphate shunt (GO:0006098)2.46424644
121regulation of mammary gland epithelial cell proliferation (GO:0033599)2.46236986
122protein complex disassembly (GO:0043241)2.44888137
123regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.44838260
124regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.44595758
125translation (GO:0006412)2.44311151
126rRNA processing (GO:0006364)2.44241620
127epithelial cell-cell adhesion (GO:0090136)2.44220359
128cellular response to zinc ion (GO:0071294)2.43961601
129mRNA catabolic process (GO:0006402)2.43364148
130regulation of apoptotic process involved in morphogenesis (GO:1902337)2.43056883
131positive regulation of interferon-alpha production (GO:0032727)2.43010469
132protein retention in ER lumen (GO:0006621)2.42641146
133proteasome assembly (GO:0043248)2.42405449
134DNA unwinding involved in DNA replication (GO:0006268)2.42281885
135myeloid dendritic cell activation (GO:0001773)2.41782454
136hyaluronan catabolic process (GO:0030214)2.41691626
137regulation of gamma-delta T cell differentiation (GO:0045586)2.41547227
138interferon-gamma-mediated signaling pathway (GO:0060333)2.41082095
139deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.40297601
140definitive hemopoiesis (GO:0060216)2.39315066
141regulation of protein heterodimerization activity (GO:0043497)2.38956121
142protein targeting to membrane (GO:0006612)2.38642689
143negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.38588399
144pteridine-containing compound biosynthetic process (GO:0042559)2.38301497
145IMP metabolic process (GO:0046040)2.37917444
146nucleobase biosynthetic process (GO:0046112)2.37263163
147decidualization (GO:0046697)2.37231221
148regulation of interferon-alpha production (GO:0032647)2.37024881
149regulation of vitamin metabolic process (GO:0030656)2.36973934
150branching involved in mammary gland duct morphogenesis (GO:0060444)2.36373995
151antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.36213240
152cellular protein complex localization (GO:0034629)2.32478035
153negative regulation of anoikis (GO:2000811)2.31739066
154activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31674956
155response to progesterone (GO:0032570)2.31282267
156negative regulation of viral release from host cell (GO:1902187)2.30395355
157endoplasmic reticulum unfolded protein response (GO:0030968)2.29584512
158activation of MAPKKK activity (GO:0000185)2.28767971
159membrane raft organization (GO:0031579)2.26824166
160response to vitamin D (GO:0033280)2.26698317
161positive regulation of nuclease activity (GO:0032075)2.26428282
162regulation of podosome assembly (GO:0071801)2.24630096
163ER-nucleus signaling pathway (GO:0006984)2.24436598
164positive regulation of chemokine biosynthetic process (GO:0045080)2.23884222
165vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.23255626
166positive regulation of extracellular matrix organization (GO:1903055)2.22156209
167retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.21475262
168desmosome organization (GO:0002934)2.20921886
169endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.20724311
170pore complex assembly (GO:0046931)2.19175294
171positive regulation of transcription factor import into nucleus (GO:0042993)2.17771499
172positive regulation of endothelial cell apoptotic process (GO:2000353)2.17582754
1733-UTR-mediated mRNA stabilization (GO:0070935)2.17517922
174positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.16645975
175regulation of nucleobase-containing compound transport (GO:0032239)2.16026871
176response to host (GO:0075136)2.13249101
177response to host defenses (GO:0052200)2.13249101
178response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.13249101
179positive regulation of epidermis development (GO:0045684)2.12316660
180regulation of integrin activation (GO:0033623)2.11553397
181basement membrane organization (GO:0071711)2.11385616
182macrophage activation involved in immune response (GO:0002281)2.09975156
183embryo implantation (GO:0007566)2.08978198
184cellular response to unfolded protein (GO:0034620)2.08594147
185endodermal cell differentiation (GO:0035987)2.07426948
186NADPH regeneration (GO:0006740)2.07152141
187mitotic nuclear envelope reassembly (GO:0007084)2.07094570
188nuclear envelope reassembly (GO:0031468)2.07094570
189regulation of necroptotic process (GO:0060544)2.06557467
190protein maturation by protein folding (GO:0022417)2.06198562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.42420819
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.27632418
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57204692
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.00430140
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.89947548
6SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.84301955
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.82949274
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.74259418
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.51866728
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50064985
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47806154
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47106946
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.44333193
14* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.43869873
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39397577
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38146130
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.35366674
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34039817
19* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.33985441
20ZNF263_19887448_ChIP-Seq_K562_Human2.26768558
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24361537
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24042609
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20916536
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19753545
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.19362934
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.19337495
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18228503
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.14986157
29MYC_22102868_ChIP-Seq_BL_Human2.12124352
30SCL_19346495_ChIP-Seq_HPC-7_Human2.11707532
31SPI1_23547873_ChIP-Seq_NB4_Human2.05783357
32* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.04423461
33VDR_23849224_ChIP-Seq_CD4+_Human2.01928136
34NOTCH1_21737748_ChIP-Seq_TLL_Human2.00620082
35GATA1_22025678_ChIP-Seq_K562_Human1.99609704
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98806835
37XRN2_22483619_ChIP-Seq_HELA_Human1.93236552
38* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.92909268
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91568973
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90840066
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.87400464
42RACK7_27058665_Chip-Seq_MCF-7_Human1.86958204
43VDR_21846776_ChIP-Seq_THP-1_Human1.86581451
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85630978
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80947634
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.76443857
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75920035
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75568375
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75101693
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74466340
51CLOCK_20551151_ChIP-Seq_293T_Human1.74266158
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73742183
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.72808742
54FOXP3_21729870_ChIP-Seq_TREG_Human1.72135279
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71441942
56* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71281405
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70503839
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69889241
59* TCF7_22412390_ChIP-Seq_EML_Mouse1.67507971
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66823376
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66821507
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65856582
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65049749
64* MYB_26560356_Chip-Seq_TH2_Human1.63390634
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61878450
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61024702
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60803212
68LXR_22292898_ChIP-Seq_THP-1_Human1.60167970
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59578094
70* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59040814
71DCP1A_22483619_ChIP-Seq_HELA_Human1.58808547
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.58495225
73GABP_19822575_ChIP-Seq_HepG2_Human1.58486238
74ATF3_27146783_Chip-Seq_COLON_Human1.58264731
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56916935
76* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.55277108
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.53159874
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53128371
79VDR_24763502_ChIP-Seq_THP-1_Human1.52559601
80MAF_26560356_Chip-Seq_TH1_Human1.51816636
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51173231
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51173231
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50640955
84* RUNX1_22412390_ChIP-Seq_EML_Mouse1.49464172
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49344503
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49314148
87* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47413497
88TTF2_22483619_ChIP-Seq_HELA_Human1.46510521
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46445990
90* MYB_26560356_Chip-Seq_TH1_Human1.44108577
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43965768
92AR_21909140_ChIP-Seq_LNCAP_Human1.43525330
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43420501
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41251944
95KDM2B_26808549_Chip-Seq_DND41_Human1.40455765
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40411347
97TFEB_21752829_ChIP-Seq_HELA_Human1.37636422
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37560947
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37081492
100ELK1_19687146_ChIP-ChIP_HELA_Human1.36615060
101CIITA_25753668_ChIP-Seq_RAJI_Human1.35229899
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34954517
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34262691
104UTX_26944678_Chip-Seq_JUKART_Human1.34002999
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33933161
106UBF1/2_26484160_Chip-Seq_HMECs_Human1.31047007
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30361727
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28430934
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28063388
110* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26888976
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26677427
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23233320
113* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23106530
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22469060
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21868612
116MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21700351
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20919913
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19222741
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18487771
120IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18033363
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17632122
122HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17386708
123ESR1_21235772_ChIP-Seq_MCF-7_Human1.17385724
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16322340
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14088329
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13807958
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13754837
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13335292
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12938054
130GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11625991
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10480757
132KDM2B_26808549_Chip-Seq_K562_Human1.10073291
133ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09639156
134NCOR1_26117541_ChIP-Seq_K562_Human1.08665306
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08086018
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07007612
137NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06998866
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06248848
139KDM2B_26808549_Chip-Seq_JURKAT_Human1.05036625
140TRIM28_21343339_ChIP-Seq_HEK293_Human1.04843795
141YY1_21170310_ChIP-Seq_MESCs_Mouse1.04167542
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03447264
143E2F1_21310950_ChIP-Seq_MCF-7_Human1.03372231
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02889605
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02397675
146MAF_26560356_Chip-Seq_TH2_Human1.02100695
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02094933
148MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01886713
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01852336
150LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01696295
151FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01000350
152STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00887191
153NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00419356
154KDM5A_27292631_Chip-Seq_BREAST_Human1.00371085
155CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00353784
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00288221
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.99541073
158ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99106115
159CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95096096
160TP53_22127205_ChIP-Seq_IMR90_Human0.94096940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.85214068
2MP0001835_abnormal_antigen_presentation3.15698298
3MP0005451_abnormal_body_composition3.13870007
4MP0003436_decreased_susceptibility_to3.08728825
5MP0003303_peritoneal_inflammation2.92974252
6MP0009785_altered_susceptibility_to2.90485693
7MP0002396_abnormal_hematopoietic_system2.84351887
8MP0003693_abnormal_embryo_hatching2.73652379
9MP0002877_abnormal_melanocyte_morpholog2.71154549
10MP0003724_increased_susceptibility_to2.66920822
11MP0000685_abnormal_immune_system2.65181633
12MP0003566_abnormal_cell_adhesion2.61210640
13MP0008438_abnormal_cutaneous_collagen2.57463818
14MP0003172_abnormal_lysosome_physiology2.45758806
15MP0005000_abnormal_immune_tolerance2.39487867
16MP0005025_abnormal_response_to2.37459330
17MP0005671_abnormal_response_to2.34020504
18MP0001800_abnormal_humoral_immune2.28644878
19MP0002419_abnormal_innate_immunity2.28309740
20MP0005076_abnormal_cell_differentiation2.27739163
21MP0002452_abnormal_antigen_presenting2.26635288
22MP0003453_abnormal_keratinocyte_physiol2.24697212
23MP0004808_abnormal_hematopoietic_stem2.23390839
24MP0002723_abnormal_immune_serum2.19354599
25MP0009333_abnormal_splenocyte_physiolog2.18156254
26MP0002420_abnormal_adaptive_immunity2.12075094
27MP0006054_spinal_hemorrhage2.11874795
28MP0001819_abnormal_immune_cell2.10801116
29MP0005464_abnormal_platelet_physiology2.07484730
30MP0000465_gastrointestinal_hemorrhage2.07131095
31MP0002148_abnormal_hypersensitivity_rea2.06882410
32MP0002398_abnormal_bone_marrow2.06872687
33MP0003091_abnormal_cell_migration2.03971484
34MP0005058_abnormal_lysosome_morphology1.98872592
35MP0003763_abnormal_thymus_physiology1.95518621
36MP0001853_heart_inflammation1.90848390
37MP0010234_abnormal_vibrissa_follicle1.89439496
38MP0000490_abnormal_crypts_of1.89428522
39MP0000689_abnormal_spleen_morphology1.88063260
40MP0002405_respiratory_system_inflammati1.87367964
41MP0001545_abnormal_hematopoietic_system1.85230070
42MP0005397_hematopoietic_system_phenotyp1.85230070
43MP0008260_abnormal_autophagy1.81083730
44MP0002722_abnormal_immune_system1.79510827
45MP0000716_abnormal_immune_system1.79264260
46MP0001790_abnormal_immune_system1.77999741
47MP0005387_immune_system_phenotype1.77999741
48MP0004957_abnormal_blastocyst_morpholog1.76687786
49MP0004233_abnormal_muscle_weight1.72457808
50MP0008007_abnormal_cellular_replicative1.70362148
51MP0002429_abnormal_blood_cell1.69549123
52MP0001845_abnormal_inflammatory_respons1.67012098
53MP0005257_abnormal_intraocular_pressure1.65785014
54MP0006082_CNS_inflammation1.65504900
55MP0004185_abnormal_adipocyte_glucose1.64710765
56MP0002796_impaired_skin_barrier1.64647907
57MP0001533_abnormal_skeleton_physiology1.57988717
58MP0003183_abnormal_peptide_metabolism1.57744080
59MP0008469_abnormal_protein_level1.56845987
60MP0004272_abnormal_basement_membrane1.53420579
61MP0005623_abnormal_meninges_morphology1.52762158
62MP0000343_altered_response_to1.52615140
63MP0010155_abnormal_intestine_physiology1.51634831
64MP0002060_abnormal_skin_morphology1.51485205
65MP0003279_aneurysm1.38635437
66MP0001849_ear_inflammation1.38036962
67MP0000733_abnormal_muscle_development1.37887105
68MP0009840_abnormal_foam_cell1.37507522
69MP0003077_abnormal_cell_cycle1.36543772
70MP0000703_abnormal_thymus_morphology1.35963321
71MP0003123_paternal_imprinting1.32802076
72MP0008057_abnormal_DNA_replication1.32291514
73MP0009278_abnormal_bone_marrow1.31457333
74MP0001216_abnormal_epidermal_layer1.28404568
75MP0005501_abnormal_skin_physiology1.27617537
76MP0002166_altered_tumor_susceptibility1.27587470
77MP0002933_joint_inflammation1.26615455
78MP0010094_abnormal_chromosome_stability1.23432785
79MP0004947_skin_inflammation1.22985201
80MP0005075_abnormal_melanosome_morpholog1.21449560
81MP0005174_abnormal_tail_pigmentation1.17262065
82MP0003866_abnormal_defecation1.16706193
83MP0003191_abnormal_cellular_cholesterol1.16580634
84MP0003656_abnormal_erythrocyte_physiolo1.16035222
85MP0000858_altered_metastatic_potential1.15839878
86MP0000678_abnormal_parathyroid_gland1.14822982
87MP0001873_stomach_inflammation1.13702282
88MP0003300_gastrointestinal_ulcer1.13440757
89MP0010307_abnormal_tumor_latency1.12803822
90MP0003111_abnormal_nucleus_morphology1.11330701
91MP0010030_abnormal_orbit_morphology1.10964321
92MP0003950_abnormal_plasma_membrane1.10945630
93MP0002332_abnormal_exercise_endurance1.09104464
94MP0005621_abnormal_cell_physiology1.08954869
95MP0005409_darkened_coat_color1.08758677
96MP0001348_abnormal_lacrimal_gland1.07923671
97MP0008058_abnormal_DNA_repair1.07783823
98MP0002998_abnormal_bone_remodeling1.05431981
99MP0003828_pulmonary_edema1.05190151
100MP0003786_premature_aging1.05149391
101MP0002006_tumorigenesis1.04763334
102MP0002019_abnormal_tumor_incidence1.04111077
103MP0003186_abnormal_redox_activity1.04045607
104MP0008995_early_reproductive_senescence1.00632310
105MP0009384_cardiac_valve_regurgitation0.98270902
106MP0005666_abnormal_adipose_tissue0.98257737
107MP0001542_abnormal_bone_strength0.98247578
108MP0004858_abnormal_nervous_system0.97973288
109MP0000767_abnormal_smooth_muscle0.97073884
110MP0000313_abnormal_cell_death0.96023906
111MP0009764_decreased_sensitivity_to0.95738370
112MP0003075_altered_response_to0.95174319
113MP0003943_abnormal_hepatobiliary_system0.94795750
114MP0001243_abnormal_dermal_layer0.92849296
115MP0005275_abnormal_skin_tensile0.92827958
116MP0001958_emphysema0.92725884
117MP0005164_abnormal_response_to0.92058882
118MP0003941_abnormal_skin_development0.91637437
119MP0005375_adipose_tissue_phenotype0.90706299
120MP0001915_intracranial_hemorrhage0.89682593
121MP0010368_abnormal_lymphatic_system0.89239348
122MP0001730_embryonic_growth_arrest0.88326791
123MP0002095_abnormal_skin_pigmentation0.88195329
124MP0000627_abnormal_mammary_gland0.87966481
125MP0003448_altered_tumor_morphology0.86877309
126MP0002254_reproductive_system_inflammat0.86209131
127MP0002896_abnormal_bone_mineralization0.82500665
128MP0004264_abnormal_extraembryonic_tissu0.82374400
129MP0000762_abnormal_tongue_morphology0.81435339
130MP0008004_abnormal_stomach_pH0.78810363
131MP0005023_abnormal_wound_healing0.78145085
132MP0000750_abnormal_muscle_regeneration0.77987509
133MP0005165_increased_susceptibility_to0.76721750
134MP0004510_myositis0.76291992
135MP0005390_skeleton_phenotype0.76124719
136MP0003795_abnormal_bone_structure0.76039107
137MP0009931_abnormal_skin_appearance0.75771792
138MP0000759_abnormal_skeletal_muscle0.75754994
139MP0003221_abnormal_cardiomyocyte_apopto0.75156660
140MP0010352_gastrointestinal_tract_polyps0.74429977
141MP0000358_abnormal_cell_content/0.73673725
142MP0008873_increased_physiological_sensi0.72934151
143MP0001663_abnormal_digestive_system0.72703368
144MP0009763_increased_sensitivity_to0.72336523
145MP0000598_abnormal_liver_morphology0.71954324
146MP0005166_decreased_susceptibility_to0.67331636
147MP0000372_irregular_coat_pigmentation0.66121152
148MP0002282_abnormal_trachea_morphology0.65309707
149MP0000249_abnormal_blood_vessel0.64557869
150MP0000609_abnormal_liver_physiology0.64130840
151MP0005319_abnormal_enzyme/_coenzyme0.63700339
152MP0009643_abnormal_urine_homeostasis0.62210947
153MP0001851_eye_inflammation0.61824182
154MP0000350_abnormal_cell_proliferation0.61501522

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.03209990
2Recurrent abscess formation (HP:0002722)4.19954541
3IgM deficiency (HP:0002850)4.09499274
4Eczematoid dermatitis (HP:0000976)4.00351032
5Thrombocytosis (HP:0001894)3.90593861
6Abnormality of cells of the erythroid lineage (HP:0012130)3.86051375
7Abnormal number of erythroid precursors (HP:0012131)3.84303191
8Recurrent bacterial skin infections (HP:0005406)3.72014662
9Premature rupture of membranes (HP:0001788)3.62465306
10Petechiae (HP:0000967)3.50735153
11Myositis (HP:0100614)3.49207309
12Reduced antithrombin III activity (HP:0001976)3.41369881
13Protrusio acetabuli (HP:0003179)3.40844300
14Amaurosis fugax (HP:0100576)3.24310183
15Abnormality of macrophages (HP:0004311)3.23254270
16Aplastic anemia (HP:0001915)3.11803177
17Entropion (HP:0000621)2.99516705
18Short nail (HP:0001799)2.96437527
19Mediastinal lymphadenopathy (HP:0100721)2.96056813
20Nasal polyposis (HP:0100582)2.90516694
21Recurrent fungal infections (HP:0002841)2.89507794
22Chronic otitis media (HP:0000389)2.87784655
23Type I transferrin isoform profile (HP:0003642)2.87536134
24Abnormality of the nasal mucosa (HP:0000433)2.83252257
25Increased connective tissue (HP:0009025)2.81476506
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80959237
27Abnormal protein N-linked glycosylation (HP:0012347)2.80959237
28Abnormal protein glycosylation (HP:0012346)2.80959237
29Abnormal glycosylation (HP:0012345)2.80959237
30Fragile skin (HP:0001030)2.80581457
31Recurrent skin infections (HP:0001581)2.79315648
32Vacuolated lymphocytes (HP:0001922)2.78699729
33Poikiloderma (HP:0001029)2.71519458
34Recurrent viral infections (HP:0004429)2.68915927
35Abnormality of T cell physiology (HP:0011840)2.68895490
36Atrophic scars (HP:0001075)2.64880052
37Dysostosis multiplex (HP:0000943)2.62780526
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.60537016
39Recurrent bronchitis (HP:0002837)2.59492534
40Recurrent gram-negative bacterial infections (HP:0005420)2.56389446
41Increased cerebral lipofuscin (HP:0011813)2.54324020
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.51239480
43Osteolytic defects of the hand bones (HP:0009699)2.51239480
44Spondylolisthesis (HP:0003302)2.50368998
45Reticulocytopenia (HP:0001896)2.49578721
46Ankle contracture (HP:0006466)2.48951704
47Prolonged bleeding time (HP:0003010)2.46679497
48Syringomyelia (HP:0003396)2.45450010
49Spinal cord lesions (HP:0100561)2.45450010
50Achilles tendon contracture (HP:0001771)2.45264156
51Abnormality of liposaccharide metabolism (HP:0010968)2.44312673
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.44312673
53Abnormality of glycolipid metabolism (HP:0010969)2.44312673
54Pallor (HP:0000980)2.43141403
55Abnormality of the distal phalanges of the toes (HP:0010182)2.42970182
56Periodontitis (HP:0000704)2.42825643
57Abnormality of T cells (HP:0002843)2.40609834
58Stomatitis (HP:0010280)2.39735676
59Cervical subluxation (HP:0003308)2.39284863
60Obstructive lung disease (HP:0006536)2.39283492
61Chronic obstructive pulmonary disease (HP:0006510)2.39283492
62Distal lower limb amyotrophy (HP:0008944)2.37676478
63Spinal rigidity (HP:0003306)2.35473785
64Vertebral compression fractures (HP:0002953)2.32537775
65Muscle fiber atrophy (HP:0100295)2.30469502
66Hyperacusis (HP:0010780)2.29606808
67Abnormal platelet function (HP:0011869)2.26398765
68Impaired platelet aggregation (HP:0003540)2.26398765
69Type 2 muscle fiber atrophy (HP:0003554)2.26229326
70Ulnar bowing (HP:0003031)2.26167834
71Macrocytic anemia (HP:0001972)2.22000960
72Distal lower limb muscle weakness (HP:0009053)2.21970889
73Loss of speech (HP:0002371)2.21134530
74Epistaxis (HP:0000421)2.20410008
75Natal tooth (HP:0000695)2.19957880
76Purpura (HP:0000979)2.17007300
77Agnosia (HP:0010524)2.16966170
78Vascular tortuosity (HP:0004948)2.16953316
79Orchitis (HP:0100796)2.16505869
80Mucopolysacchariduria (HP:0008155)2.16092749
81Urinary glycosaminoglycan excretion (HP:0003541)2.16092749
82Flat acetabular roof (HP:0003180)2.15499236
83Pustule (HP:0200039)2.14017965
84Poor head control (HP:0002421)2.13455021
85Genu recurvatum (HP:0002816)2.13250097
86Gastrointestinal inflammation (HP:0004386)2.12111971
87Cellulitis (HP:0100658)2.10629096
88Selective tooth agenesis (HP:0001592)2.10560642
89Arterial tortuosity (HP:0005116)2.10505138
90Vasculitis (HP:0002633)2.10498091
91Mitral regurgitation (HP:0001653)2.10420206
92Abnormality of the Achilles tendon (HP:0005109)2.10161756
93Meningitis (HP:0001287)2.07373058
94IgG deficiency (HP:0004315)2.06762372
95Blue sclerae (HP:0000592)2.06408054
96Tetraparesis (HP:0002273)2.05803386
97Hepatocellular necrosis (HP:0001404)2.05277930
98Chronic mucocutaneous candidiasis (HP:0002728)2.04276748
99Recurrent cutaneous fungal infections (HP:0011370)2.04276748
100Spontaneous hematomas (HP:0007420)2.04166590
101Elbow flexion contracture (HP:0002987)2.04148857
102Micronodular cirrhosis (HP:0001413)2.03454812
103Gastrointestinal stroma tumor (HP:0100723)2.03422310
104Interstitial pulmonary disease (HP:0006530)2.02827414
105Dilatation of the ascending aorta (HP:0005111)2.02374401
106Generalized amyotrophy (HP:0003700)2.02342534
107Wormian bones (HP:0002645)2.01890341
108Gingivitis (HP:0000230)2.01484994
109Joint stiffness (HP:0001387)2.01284669
11011 pairs of ribs (HP:0000878)2.01171437
111Abnormal delayed hypersensitivity skin test (HP:0002963)2.00750211
112Chest pain (HP:0100749)2.00224595
113Thin bony cortex (HP:0002753)1.99883603
114Progressive muscle weakness (HP:0003323)1.99678432
115Subacute progressive viral hepatitis (HP:0006572)1.99546475
116Beaking of vertebral bodies (HP:0004568)1.98515658
117Cerebral aneurysm (HP:0004944)1.97241682
118Abnormality of the distal phalanx of the thumb (HP:0009617)1.96021284
119Thoracic kyphosis (HP:0002942)1.95379382
120Inflammation of the large intestine (HP:0002037)1.94943221
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94830382
122Panhypogammaglobulinemia (HP:0003139)1.94339085
123Long palpebral fissure (HP:0000637)1.93986162
124Centrally nucleated skeletal muscle fibers (HP:0003687)1.93655977
125Thick nail (HP:0001805)1.93304236
126Hepatic necrosis (HP:0002605)1.92840094
127Fatigue (HP:0012378)1.92425268
128Difficulty climbing stairs (HP:0003551)1.92134976
129Basal ganglia calcification (HP:0002135)1.91157820
130Increased variability in muscle fiber diameter (HP:0003557)1.91027198
131Exertional dyspnea (HP:0002875)1.89865778
132Abnormality of skeletal muscle fiber size (HP:0012084)1.87880231
133Increased serum ferritin (HP:0003281)1.87372385
134Nuclear cataract (HP:0100018)1.86571656
135Nausea (HP:0002018)1.86386257
136Trismus (HP:0000211)1.86097353
137Neurodegeneration (HP:0002180)1.84986306
138Disproportionate tall stature (HP:0001519)1.84847755
139Sparse lateral eyebrow (HP:0005338)1.83829916
140Hepatosplenomegaly (HP:0001433)1.83464372
141Lymphoma (HP:0002665)1.82884680
142Broad face (HP:0000283)1.81877585
143Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81586056
144Abnormality of polysaccharide metabolism (HP:0011012)1.81586056
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81586056
146Aortic aneurysm (HP:0004942)1.81480460
147Upper motor neuron abnormality (HP:0002127)1.81109063
148Abnormality of carpal bone ossification (HP:0006257)1.80960342
149Advanced eruption of teeth (HP:0006288)1.80409285
150Abnormal ossification of hand bones (HP:0005921)1.80406645
151Leukocytosis (HP:0001974)1.79596651
152Myocardial infarction (HP:0001658)1.79578203
153Abnormality of the phalanges of the hallux (HP:0010057)1.79013756
154Mildly elevated creatine phosphokinase (HP:0008180)1.78285413
155Mitral valve prolapse (HP:0001634)1.78194289
156Milia (HP:0001056)1.76617967
157Axonal loss (HP:0003447)1.76101175
158Abnormality of the lumbar spine (HP:0100712)1.75650081
159Lymphopenia (HP:0001888)1.75513248
160Upper limb amyotrophy (HP:0009129)1.75439301
161Distal upper limb amyotrophy (HP:0007149)1.75439301
162Asymmetry of the thorax (HP:0001555)1.75254029
163Systemic lupus erythematosus (HP:0002725)1.75207119
164Ankyloglossia (HP:0010296)1.74890154
165Bone pain (HP:0002653)1.74876143
166T lymphocytopenia (HP:0005403)1.74627238
167Aortic dissection (HP:0002647)1.73453192
168Abnormality of oral frenula (HP:0000190)1.73222282
169Episodic fever (HP:0001954)1.71662575
170Nail dystrophy (HP:0008404)1.71634279
171Aneurysm (HP:0002617)1.71227949
172Recurrent pneumonia (HP:0006532)1.71131890
173Oral leukoplakia (HP:0002745)1.70874594
174Joint laxity (HP:0001388)1.70180207
175Dislocated radial head (HP:0003083)1.67902478
176Shallow orbits (HP:0000586)1.66744671
177Abnormality of the thoracic spine (HP:0100711)1.66699779
178Flattened epiphyses (HP:0003071)1.63528891
179Patellar dislocation (HP:0002999)1.63384109
180Hyperparathyroidism (HP:0000843)1.62694873
181Alopecia of scalp (HP:0002293)1.61783297
182Spinal cord compression (HP:0002176)1.61728746
183Abnormality of dentin (HP:0010299)1.60574962
184Reduced subcutaneous adipose tissue (HP:0003758)1.59349939
185Bladder diverticulum (HP:0000015)1.55947053
186Abnormality of the umbilical cord (HP:0010881)1.55489095
187Abnormality of the radial head (HP:0003995)1.54982593
188Deviation of the thumb (HP:0009603)1.54794853
189Type 1 muscle fiber predominance (HP:0003803)1.53932171
190Congenital glaucoma (HP:0001087)1.51472770
191Biconcave vertebral bodies (HP:0004586)1.50731022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT33.23025292
2MAP4K13.15888474
3KIT3.15514766
4SMG13.03292787
5NME22.88580760
6PRPF4B2.85941809
7TBK12.63945020
8PIM22.63673636
9SIK12.61179627
10IRAK42.33330110
11EPHA32.28623666
12CDK122.28548224
13ZAP702.26686277
14ERN12.24928218
15WEE12.20314029
16TTN2.20275985
17MST1R2.18826333
18EPHA22.17613292
19STK162.17499634
20ACVR1B1.97259903
21BUB11.86916218
22ICK1.82688460
23TEC1.82198323
24RPS6KA41.80746519
25KDR1.77145902
26TYK21.76872210
27BTK1.76691822
28TXK1.74810448
29PDGFRA1.74771756
30TNIK1.71264008
31CSF1R1.68338690
32STK101.67570181
33RIPK11.67326443
34TGFBR21.66721097
35EEF2K1.63863579
36BLK1.61201765
37TGFBR11.54496280
38EIF2AK31.50577720
39EPHB11.48866034
40EIF2AK11.44402035
41TSSK61.44317919
42RIPK41.43764720
43IKBKE1.43117977
44JAK31.41437013
45MOS1.40875842
46SCYL21.39968284
47MAP3K131.36264904
48LATS21.34668902
49LRRK21.29506603
50MAP2K31.26059686
51PTK21.20831688
52DYRK31.20628319
53NLK1.18974187
54MAP3K111.17948916
55IRAK21.16853742
56DDR21.15160641
57MATK1.14096959
58MAP3K11.13663471
59PIM11.13482751
60TAOK11.11897837
61MET1.09270660
62KSR21.08978382
63VRK11.07401271
64IKBKB1.06638130
65SYK1.06602945
66NEK91.05666460
67SIK31.05263057
68TESK11.03374794
69MAPKAPK30.99083592
70LYN0.96174014
71LCK0.95667639
72MTOR0.95339151
73FGFR40.94234791
74FES0.91712180
75RPS6KB20.89713963
76CDC42BPA0.88789552
77MELK0.87557653
78PAK40.87518422
79BRD40.86003998
80MAP3K100.82425624
81MAP3K30.82385952
82TESK20.81485738
83PKN20.78560389
84PRKD20.76986842
85ITK0.76539947
86RAF10.75672277
87MAP3K140.75659184
88GRK60.75352851
89CDC70.72995122
90PASK0.72512191
91CDK70.72459826
92HCK0.71944502
93CSK0.71794424
94MST40.71721633
95NEK20.70784803
96CDK60.69160816
97BRAF0.68058864
98RPS6KA60.66016782
99MAP3K80.65484459
100MAP3K90.65118910
101PRKG20.64598190
102ERBB40.63698714
103IRAK10.63161597
104TRIB30.63074173
105CDK40.61435496
106BRSK20.60976905
107BMX0.60831516
108MAPK110.59189875
109MAP3K120.58992036
110PAK20.58228984
111GRK70.57430992
112TAOK20.55312386
113SRPK10.54794491
114RPS6KL10.54126879
115RPS6KC10.54126879
116LATS10.53483927
117EIF2AK20.53346124
118MAPK40.53172256
119PTK60.52719838
120MAP3K20.52366482
121MAP3K50.52079237
122CDK90.51119673
123PDGFRB0.50908131
124EPHB20.50593614
125MAPKAPK20.50189791
126TAOK30.49467099
127BCKDK0.48705519
128ATR0.48408006
129MYLK0.47925821
130MAP3K60.47845657
131CCNB10.46663842
132ABL20.45578838
133LMTK20.45224486
134CLK10.44439858
135JAK20.44119497
136IRAK30.44001201
137MARK30.43718994
138CAMKK20.43700901
139STK240.43127347
140DMPK0.41940849
141PDPK10.41885646
142ARAF0.41791155
143KSR10.41380500
144TLK10.40948563
145AURKA0.40814131
146NTRK10.40655181
147RPS6KA50.39854204
148JAK10.39161637
149MKNK10.39053397
150CDK80.37841132
151CHUK0.36604864
152TRPM70.36292646
153TAF10.35702927
154RPS6KA20.35280234
155MAPKAPK50.33180877

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.51170869
2DNA replication_Homo sapiens_hsa030303.50929374
3Proteasome_Homo sapiens_hsa030502.86069880
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.67770975
5RNA polymerase_Homo sapiens_hsa030202.55414703
6Mismatch repair_Homo sapiens_hsa034302.18276557
7Antigen processing and presentation_Homo sapiens_hsa046122.16341732
8Pyrimidine metabolism_Homo sapiens_hsa002402.02673208
9Bladder cancer_Homo sapiens_hsa052192.02155966
10Leishmaniasis_Homo sapiens_hsa051402.01869287
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93989927
12Spliceosome_Homo sapiens_hsa030401.92831645
13Protein export_Homo sapiens_hsa030601.86698581
14Legionellosis_Homo sapiens_hsa051341.80798561
15Primary immunodeficiency_Homo sapiens_hsa053401.78787447
16Base excision repair_Homo sapiens_hsa034101.78118958
17Pancreatic cancer_Homo sapiens_hsa052121.68313128
18Other glycan degradation_Homo sapiens_hsa005111.60827112
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.60599684
20Nucleotide excision repair_Homo sapiens_hsa034201.59839948
21Hematopoietic cell lineage_Homo sapiens_hsa046401.59294992
22Herpes simplex infection_Homo sapiens_hsa051681.58378327
23Folate biosynthesis_Homo sapiens_hsa007901.49959867
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49288555
25Measles_Homo sapiens_hsa051621.47454275
26Homologous recombination_Homo sapiens_hsa034401.47011267
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44080970
28Non-small cell lung cancer_Homo sapiens_hsa052231.43361487
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.41303402
30RNA transport_Homo sapiens_hsa030131.40012745
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.39880931
32Osteoclast differentiation_Homo sapiens_hsa043801.37992397
33B cell receptor signaling pathway_Homo sapiens_hsa046621.37219602
34N-Glycan biosynthesis_Homo sapiens_hsa005101.35715524
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34732952
36Sulfur relay system_Homo sapiens_hsa041221.34381216
37Amoebiasis_Homo sapiens_hsa051461.34331820
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32862077
39Notch signaling pathway_Homo sapiens_hsa043301.32090095
40Proteoglycans in cancer_Homo sapiens_hsa052051.30556355
41Renal cell carcinoma_Homo sapiens_hsa052111.29030132
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28947098
43Focal adhesion_Homo sapiens_hsa045101.26626481
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.26139785
45Malaria_Homo sapiens_hsa051441.25946832
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25828144
47Prion diseases_Homo sapiens_hsa050201.25055103
48Epstein-Barr virus infection_Homo sapiens_hsa051691.21148594
49One carbon pool by folate_Homo sapiens_hsa006701.17895864
50Endometrial cancer_Homo sapiens_hsa052131.17876015
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17849187
52VEGF signaling pathway_Homo sapiens_hsa043701.16017836
53Acute myeloid leukemia_Homo sapiens_hsa052211.15821552
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14480669
55Staphylococcus aureus infection_Homo sapiens_hsa051501.13436765
56Prostate cancer_Homo sapiens_hsa052151.12976765
57Lysosome_Homo sapiens_hsa041421.12798840
58Pentose phosphate pathway_Homo sapiens_hsa000301.12022192
59Shigellosis_Homo sapiens_hsa051311.11990945
60MicroRNAs in cancer_Homo sapiens_hsa052061.09973059
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09516390
62Apoptosis_Homo sapiens_hsa042101.09036174
63Cell cycle_Homo sapiens_hsa041101.08619138
64Pertussis_Homo sapiens_hsa051331.02817176
65Jak-STAT signaling pathway_Homo sapiens_hsa046301.01429460
66Neurotrophin signaling pathway_Homo sapiens_hsa047221.00922567
67Prolactin signaling pathway_Homo sapiens_hsa049171.00516893
68RNA degradation_Homo sapiens_hsa030181.00244832
69ECM-receptor interaction_Homo sapiens_hsa045120.99664760
70Tuberculosis_Homo sapiens_hsa051520.97842876
71Adherens junction_Homo sapiens_hsa045200.96853399
72Influenza A_Homo sapiens_hsa051640.96024397
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94841709
74p53 signaling pathway_Homo sapiens_hsa041150.94688707
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93281500
76Non-homologous end-joining_Homo sapiens_hsa034500.93082616
77mTOR signaling pathway_Homo sapiens_hsa041500.91376606
78Glioma_Homo sapiens_hsa052140.90626787
79Asthma_Homo sapiens_hsa053100.89819832
80Allograft rejection_Homo sapiens_hsa053300.89671951
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89393721
82Toxoplasmosis_Homo sapiens_hsa051450.89018018
83Hepatitis B_Homo sapiens_hsa051610.88380327
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87714756
85Viral carcinogenesis_Homo sapiens_hsa052030.84975389
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84779950
87ErbB signaling pathway_Homo sapiens_hsa040120.83131279
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81289115
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80661221
90Viral myocarditis_Homo sapiens_hsa054160.80197052
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79895041
92Insulin signaling pathway_Homo sapiens_hsa049100.78773594
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77660215
94Purine metabolism_Homo sapiens_hsa002300.77228134
95Thyroid cancer_Homo sapiens_hsa052160.76580343
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74987378
97T cell receptor signaling pathway_Homo sapiens_hsa046600.72870362
98Insulin resistance_Homo sapiens_hsa049310.72232582
99Colorectal cancer_Homo sapiens_hsa052100.71782378
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71768756
101Systemic lupus erythematosus_Homo sapiens_hsa053220.71438835
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.70820038
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70620235
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.69541595
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67483974
106TNF signaling pathway_Homo sapiens_hsa046680.67287372
107Pathways in cancer_Homo sapiens_hsa052000.66717335
108Melanoma_Homo sapiens_hsa052180.66031118
109HTLV-I infection_Homo sapiens_hsa051660.64520840
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63391537
111African trypanosomiasis_Homo sapiens_hsa051430.63384606
112Endocytosis_Homo sapiens_hsa041440.62914954
113Regulation of autophagy_Homo sapiens_hsa041400.62437480
114Phagosome_Homo sapiens_hsa041450.61600720
115Basal transcription factors_Homo sapiens_hsa030220.59367850
116FoxO signaling pathway_Homo sapiens_hsa040680.58577548
117Chemokine signaling pathway_Homo sapiens_hsa040620.58320316
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58131670
119HIF-1 signaling pathway_Homo sapiens_hsa040660.57079579
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57076555
121Galactose metabolism_Homo sapiens_hsa000520.56975401
122Platelet activation_Homo sapiens_hsa046110.56164624
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.54566822
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54324643
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54249975
126Inositol phosphate metabolism_Homo sapiens_hsa005620.53930663
127Sphingolipid metabolism_Homo sapiens_hsa006000.53119521
128Graft-versus-host disease_Homo sapiens_hsa053320.52460156
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51640053
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51290938
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.51242490
132Rheumatoid arthritis_Homo sapiens_hsa053230.50775370
133Vibrio cholerae infection_Homo sapiens_hsa051100.48823159
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48316362
135Salmonella infection_Homo sapiens_hsa051320.48275562
136Selenocompound metabolism_Homo sapiens_hsa004500.44872468
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44237058
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43117441
139Type I diabetes mellitus_Homo sapiens_hsa049400.42961904
140Small cell lung cancer_Homo sapiens_hsa052220.42831532
141Chronic myeloid leukemia_Homo sapiens_hsa052200.41831773
142Hepatitis C_Homo sapiens_hsa051600.41373542
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38391086
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35102484
145Fructose and mannose metabolism_Homo sapiens_hsa000510.33187613
146Parkinsons disease_Homo sapiens_hsa050120.32432348

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