TMEM186

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a potential transmembrane protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.14967318
2ribosomal small subunit assembly (GO:0000028)5.09289635
3maturation of SSU-rRNA (GO:0030490)4.60687441
4cytochrome complex assembly (GO:0017004)4.45317963
5proteasome assembly (GO:0043248)4.31728799
6chaperone-mediated protein transport (GO:0072321)4.21179240
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17319446
8cullin deneddylation (GO:0010388)4.09385932
9respiratory electron transport chain (GO:0022904)3.99986365
10electron transport chain (GO:0022900)3.99711750
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.98407301
12tricarboxylic acid cycle (GO:0006099)3.97702538
13viral transcription (GO:0019083)3.95570494
14protein deneddylation (GO:0000338)3.92778193
15peptidyl-histidine modification (GO:0018202)3.86720936
16translational termination (GO:0006415)3.81735638
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81577131
18oxidative phosphorylation (GO:0006119)3.78195332
19DNA strand elongation involved in DNA replication (GO:0006271)3.73732464
20protein-cofactor linkage (GO:0018065)3.73671911
21translational elongation (GO:0006414)3.72631645
22platelet dense granule organization (GO:0060155)3.72617957
23DNA unwinding involved in DNA replication (GO:0006268)3.67351701
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61867839
25DNA strand elongation (GO:0022616)3.59869529
26telomere maintenance via semi-conservative replication (GO:0032201)3.59101012
27nucleobase biosynthetic process (GO:0046112)3.56490642
28NADH metabolic process (GO:0006734)3.55193727
29cotranslational protein targeting to membrane (GO:0006613)3.54651561
30protein targeting to ER (GO:0045047)3.51279184
31ubiquinone metabolic process (GO:0006743)3.50397933
32purine nucleobase biosynthetic process (GO:0009113)3.44380128
33water-soluble vitamin biosynthetic process (GO:0042364)3.44260482
34DNA replication initiation (GO:0006270)3.44024188
35termination of RNA polymerase III transcription (GO:0006386)3.43853272
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.43853272
37protein localization to endoplasmic reticulum (GO:0070972)3.40523135
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.38802370
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36445427
40mannosylation (GO:0097502)3.36159578
41respiratory chain complex IV assembly (GO:0008535)3.33969809
42cellular ketone body metabolic process (GO:0046950)3.32709853
43regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.29561207
44DNA damage response, detection of DNA damage (GO:0042769)3.29080935
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28187429
46ribosomal small subunit biogenesis (GO:0042274)3.27399315
47translational initiation (GO:0006413)3.26821708
48folic acid-containing compound biosynthetic process (GO:0009396)3.24532499
49mitochondrial RNA metabolic process (GO:0000959)3.22045351
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21424317
51preassembly of GPI anchor in ER membrane (GO:0016254)3.19382566
52pteridine-containing compound biosynthetic process (GO:0042559)3.17790948
53oxaloacetate metabolic process (GO:0006107)3.14681950
54pseudouridine synthesis (GO:0001522)3.12907464
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12483142
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12050495
57formation of translation preinitiation complex (GO:0001731)3.08828947
58ribosome biogenesis (GO:0042254)3.06798728
59maturation of 5.8S rRNA (GO:0000460)3.06562125
60protoporphyrinogen IX metabolic process (GO:0046501)3.01810292
61IMP biosynthetic process (GO:0006188)3.01423410
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00813175
63behavioral response to nicotine (GO:0035095)3.00450173
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99203070
65ribonucleoprotein complex disassembly (GO:0032988)2.98634867
66regulation of cellular amino acid metabolic process (GO:0006521)2.98634716
67telomere maintenance via recombination (GO:0000722)2.96388119
68rRNA processing (GO:0006364)2.96360050
69organelle disassembly (GO:1903008)2.96010163
70protein targeting to mitochondrion (GO:0006626)2.95403642
71tRNA processing (GO:0008033)2.95344077
72establishment of protein localization to mitochondrion (GO:0072655)2.95342834
73cellular protein complex disassembly (GO:0043624)2.94709392
74tricarboxylic acid metabolic process (GO:0072350)2.94667914
75ketone body metabolic process (GO:1902224)2.94341901
76hydrogen ion transmembrane transport (GO:1902600)2.94200399
77rRNA modification (GO:0000154)2.93964487
78regulation of acyl-CoA biosynthetic process (GO:0050812)2.92738653
79L-methionine salvage (GO:0071267)2.91808764
80L-methionine biosynthetic process (GO:0071265)2.91808764
81amino acid salvage (GO:0043102)2.91808764
82rRNA methylation (GO:0031167)2.91711229
83GTP biosynthetic process (GO:0006183)2.91684533
84glycine metabolic process (GO:0006544)2.91630882
85intracellular protein transmembrane import (GO:0044743)2.91099904
86viral life cycle (GO:0019058)2.89536852
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89479324
88negative regulation of RNA splicing (GO:0033119)2.89450362
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89146987
90purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88913643
91pyrimidine nucleotide catabolic process (GO:0006244)2.88845754
92ribonucleoprotein complex biogenesis (GO:0022613)2.88205484
93ATP biosynthetic process (GO:0006754)2.88038626
94L-fucose catabolic process (GO:0042355)2.87477176
95fucose catabolic process (GO:0019317)2.87477176
96L-fucose metabolic process (GO:0042354)2.87477176
97purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86674410
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85825851
99negative regulation of ligase activity (GO:0051352)2.85825851
100rRNA metabolic process (GO:0016072)2.84891333
101protoporphyrinogen IX biosynthetic process (GO:0006782)2.84849759
102folic acid metabolic process (GO:0046655)2.84493858
103pentose-phosphate shunt (GO:0006098)2.84299144
104protein localization to mitochondrion (GO:0070585)2.84288789
105base-excision repair, AP site formation (GO:0006285)2.83542882
106signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82903303
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82903303
108signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82903303
109spliceosomal snRNP assembly (GO:0000387)2.82558492
110IMP metabolic process (GO:0046040)2.81956119
111translation (GO:0006412)2.81479952
112aldehyde catabolic process (GO:0046185)2.81310117
113purine-containing compound salvage (GO:0043101)2.80689057
114protein complex disassembly (GO:0043241)2.79882275
115ATP synthesis coupled proton transport (GO:0015986)2.78698503
116energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78698503
117regulation of cofactor metabolic process (GO:0051193)2.78602833
118regulation of coenzyme metabolic process (GO:0051196)2.78602833
119signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77976446
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77976446
121proton transport (GO:0015992)2.77970392
122DNA catabolic process, exonucleolytic (GO:0000738)2.77019550
123protein neddylation (GO:0045116)2.76855391
124translesion synthesis (GO:0019985)2.76704968
125DNA double-strand break processing (GO:0000729)2.76456587
126branched-chain amino acid catabolic process (GO:0009083)2.76327713
1272-oxoglutarate metabolic process (GO:0006103)2.76094410
128pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.75302236
129succinate metabolic process (GO:0006105)2.73095570
130quinone biosynthetic process (GO:1901663)2.72572201
131ubiquinone biosynthetic process (GO:0006744)2.72572201
132exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71381777
133mitochondrial respiratory chain complex assembly (GO:0033108)2.71309979
134NADH dehydrogenase complex assembly (GO:0010257)2.70658161
135mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70658161
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.70658161
137hydrogen transport (GO:0006818)2.70535310
138tRNA metabolic process (GO:0006399)2.70181508
139pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69920818
140cellular component biogenesis (GO:0044085)2.69522155
141heme biosynthetic process (GO:0006783)2.69185004
142transcription from mitochondrial promoter (GO:0006390)2.67984502
143signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67895755
144signal transduction involved in DNA damage checkpoint (GO:0072422)2.67895755
145kynurenine metabolic process (GO:0070189)2.67853037
146signal transduction involved in cell cycle checkpoint (GO:0072395)2.67449591
147nuclear-transcribed mRNA catabolic process (GO:0000956)2.67185755
148nucleoside salvage (GO:0043174)2.67175768
149macromolecular complex disassembly (GO:0032984)2.66848561
150pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66450520
151mitotic recombination (GO:0006312)2.66241293
152tRNA modification (GO:0006400)2.65906540
153lysine catabolic process (GO:0006554)2.65496432
154lysine metabolic process (GO:0006553)2.65496432
155mitochondrial transport (GO:0006839)2.65420989
156peptidyl-arginine omega-N-methylation (GO:0035247)2.64270349
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64217504
158methionine biosynthetic process (GO:0009086)2.63845423
159methionine metabolic process (GO:0006555)2.63347309
160iron-sulfur cluster assembly (GO:0016226)2.61712199
161metallo-sulfur cluster assembly (GO:0031163)2.61712199
162negative regulation of erythrocyte differentiation (GO:0045647)2.61521418
163regulation of sulfur metabolic process (GO:0042762)2.61488238
164regulation of mitochondrial translation (GO:0070129)2.61465206
165protein complex biogenesis (GO:0070271)2.61071605
166tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60582951
167RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60582951
168CENP-A containing nucleosome assembly (GO:0034080)2.60573718
169telomere maintenance via telomere lengthening (GO:0010833)2.60228471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.64272271
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.23056681
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.71215378
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20073678
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.13574701
6ZNF274_21170338_ChIP-Seq_K562_Hela2.93205826
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91181751
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86330792
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.81918263
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.78732385
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.72830480
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63962058
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50822292
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49706518
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45601755
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37665442
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33757854
18XRN2_22483619_ChIP-Seq_HELA_Human2.29429313
19VDR_23849224_ChIP-Seq_CD4+_Human2.23483841
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22269293
21VDR_22108803_ChIP-Seq_LS180_Human2.21733166
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21544863
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.19415169
24FOXP3_21729870_ChIP-Seq_TREG_Human2.18679233
25CIITA_25753668_ChIP-Seq_RAJI_Human2.18484916
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17744039
27MYC_22102868_ChIP-Seq_BL_Human2.16541939
28MYC_18940864_ChIP-ChIP_HL60_Human2.08192694
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08062264
30* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00392252
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99866276
32* GABP_19822575_ChIP-Seq_HepG2_Human1.95577467
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94284877
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93066884
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92941756
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92854824
37DCP1A_22483619_ChIP-Seq_HELA_Human1.92049490
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.91488086
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.86657911
40IGF1R_20145208_ChIP-Seq_DFB_Human1.85806995
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.85144622
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84268553
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82733363
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82290581
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77577640
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67793238
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66409945
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66122389
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.66106305
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64550883
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.63416747
52IRF1_19129219_ChIP-ChIP_H3396_Human1.59503531
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57137352
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56524954
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56237963
56* TTF2_22483619_ChIP-Seq_HELA_Human1.54533512
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52992266
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52828723
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50001033
60SCL_19346495_ChIP-Seq_HPC-7_Human1.47936785
61VDR_21846776_ChIP-Seq_THP-1_Human1.42153588
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41190460
63TP53_22573176_ChIP-Seq_HFKS_Human1.40908881
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.39799519
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39515783
66GATA1_22025678_ChIP-Seq_K562_Human1.38930937
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36503074
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36141907
69AR_21909140_ChIP-Seq_LNCAP_Human1.35645232
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35061096
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34206714
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.33697111
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29021539
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28948687
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28517240
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27682956
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26140443
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25679054
79KDM5A_27292631_Chip-Seq_BREAST_Human1.24235687
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.24125825
81* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20215410
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.19516771
83EWS_26573619_Chip-Seq_HEK293_Human1.18479979
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15287264
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15259427
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14437442
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12597209
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12521447
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12478843
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12276287
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10628652
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09654920
93AR_20517297_ChIP-Seq_VCAP_Human1.06744028
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06175816
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06040153
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03693918
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03031841
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02915214
99ELK1_22589737_ChIP-Seq_MCF10A_Human1.02872337
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02644209
101ZNF263_19887448_ChIP-Seq_K562_Human1.02104036
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01783777
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01646360
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01558503
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01517631
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01287393
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.01287393
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99861544
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99511587
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99486971
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98898112
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97954297
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96254230
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96174656
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95538002
116* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94850359
117SPI1_23547873_ChIP-Seq_NB4_Human0.93632719
118* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92787351
119ELK1_19687146_ChIP-ChIP_HELA_Human0.92666476
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92552895
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92315933
122NCOR_22424771_ChIP-Seq_293T_Human0.91959085
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.90942863
124NANOG_20526341_ChIP-Seq_ESCs_Human0.90900036
125TFEB_21752829_ChIP-Seq_HELA_Human0.90496251
126* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90051788
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.89892069
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87334763
129FUS_26573619_Chip-Seq_HEK293_Human0.86876759
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86361394
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86074264
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85466969
133PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85401261
134SOX2_19829295_ChIP-Seq_ESCs_Human0.84791228
135NANOG_19829295_ChIP-Seq_ESCs_Human0.84791228
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82434384
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80802327
138MYC_19829295_ChIP-Seq_ESCs_Human0.79605986
139* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79082445
140ERG_20517297_ChIP-Seq_VCAP_Human0.78441356
141ERA_21632823_ChIP-Seq_H3396_Human0.76424301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006036_abnormal_mitochondrial_physio3.26478159
2MP0003693_abnormal_embryo_hatching3.23151351
3MP0002396_abnormal_hematopoietic_system3.07527376
4MP0004147_increased_porphyrin_level3.01786812
5MP0002139_abnormal_hepatobiliary_system3.00499044
6MP0003806_abnormal_nucleotide_metabolis2.96774927
7MP0005084_abnormal_gallbladder_morpholo2.91152984
8MP0003136_yellow_coat_color2.67938115
9MP0002837_dystrophic_cardiac_calcinosis2.64219962
10MP0006072_abnormal_retinal_apoptosis2.57837181
11MP0010094_abnormal_chromosome_stability2.56860648
12MP0002102_abnormal_ear_morphology2.55028296
13MP0004957_abnormal_blastocyst_morpholog2.51218334
14MP0003646_muscle_fatigue2.45411903
15MP0003195_calcinosis2.35778998
16MP0005365_abnormal_bile_salt2.32964051
17MP0003656_abnormal_erythrocyte_physiolo2.32526435
18MP0008877_abnormal_DNA_methylation2.28359618
19MP0003077_abnormal_cell_cycle2.27563170
20MP0006035_abnormal_mitochondrial_morpho2.25706956
21MP0003111_abnormal_nucleus_morphology2.24867470
22MP0008057_abnormal_DNA_replication2.24732699
23MP0005551_abnormal_eye_electrophysiolog2.05436243
24MP0008007_abnormal_cellular_replicative2.04246701
25MP0003186_abnormal_redox_activity1.99058174
26MP0004215_abnormal_myocardial_fiber1.95680390
27MP0005253_abnormal_eye_physiology1.94872229
28MP0003221_abnormal_cardiomyocyte_apopto1.91147931
29MP0004084_abnormal_cardiac_muscle1.88334545
30MP0000372_irregular_coat_pigmentation1.87231502
31MP0003011_delayed_dark_adaptation1.86053031
32MP0002736_abnormal_nociception_after1.72039125
33MP0000747_muscle_weakness1.71721509
34MP0002938_white_spotting1.69559138
35MP0003718_maternal_effect1.67973774
36MP0005266_abnormal_metabolism1.67106571
37MP0001485_abnormal_pinna_reflex1.66298107
38MP0008872_abnormal_physiological_respon1.65121554
39MP0005360_urolithiasis1.64644504
40MP0005075_abnormal_melanosome_morpholog1.59329533
41MP0005085_abnormal_gallbladder_physiolo1.58446567
42MP0008058_abnormal_DNA_repair1.56481135
43MP0004808_abnormal_hematopoietic_stem1.56311606
44MP0004142_abnormal_muscle_tone1.54962973
45MP0005330_cardiomyopathy1.53337393
46MP0005645_abnormal_hypothalamus_physiol1.52885387
47MP0001968_abnormal_touch/_nociception1.52378521
48MP0003878_abnormal_ear_physiology1.52343750
49MP0005377_hearing/vestibular/ear_phenot1.52343750
50MP0004036_abnormal_muscle_relaxation1.47591077
51MP0000751_myopathy1.46423035
52MP0000749_muscle_degeneration1.42953294
53MP0004133_heterotaxia1.37847793
54MP0009840_abnormal_foam_cell1.37607046
55MP0000490_abnormal_crypts_of1.37534393
56MP0006054_spinal_hemorrhage1.36424372
57MP0005397_hematopoietic_system_phenotyp1.34412338
58MP0001545_abnormal_hematopoietic_system1.34412338
59MP0009333_abnormal_splenocyte_physiolog1.33994473
60MP0001986_abnormal_taste_sensitivity1.32692714
61MP0000609_abnormal_liver_physiology1.29743058
62MP0003122_maternal_imprinting1.29589628
63MP0002653_abnormal_ependyma_morphology1.29348153
64MP0003786_premature_aging1.28558438
65MP0002269_muscular_atrophy1.28353737
66MP0000358_abnormal_cell_content/1.26485015
67MP0003567_abnormal_fetal_cardiomyocyte1.25522443
68MP0001730_embryonic_growth_arrest1.25098167
69MP0008789_abnormal_olfactory_epithelium1.25036964
70MP0000631_abnormal_neuroendocrine_gland1.24828320
71MP0003763_abnormal_thymus_physiology1.23927100
72MP0009046_muscle_twitch1.23229586
73MP0005379_endocrine/exocrine_gland_phen1.20744221
74MP0003283_abnormal_digestive_organ1.18529656
75MP0002722_abnormal_immune_system1.17818063
76MP0002398_abnormal_bone_marrow1.17446425
77MP0000689_abnormal_spleen_morphology1.15859365
78MP0001324_abnormal_eye_pigmentation1.15664746
79MP0001764_abnormal_homeostasis1.15162438
80MP0003868_abnormal_feces_composition1.14739235
81MP0002080_prenatal_lethality1.14132976
82MP0004130_abnormal_muscle_cell1.12797492
83MP0005332_abnormal_amino_acid1.12145541
84MP0000465_gastrointestinal_hemorrhage1.11690905
85MP0001919_abnormal_reproductive_system1.10907542
86MP0006276_abnormal_autonomic_nervous1.10849674
87MP0003172_abnormal_lysosome_physiology1.10573593
88MP0005646_abnormal_pituitary_gland1.10172837
89MP0002277_abnormal_respiratory_mucosa1.10051299
90MP0008875_abnormal_xenobiotic_pharmacok1.08660395
91MP0004742_abnormal_vestibular_system1.08625320
92MP0001929_abnormal_gametogenesis1.08198331
93MP0004885_abnormal_endolymph1.07902458
94MP0002876_abnormal_thyroid_physiology1.07595739
95MP0002928_abnormal_bile_duct1.07175047
96MP0005584_abnormal_enzyme/coenzyme_acti1.06595005
97MP0005389_reproductive_system_phenotype1.05698861
98MP0001905_abnormal_dopamine_level1.05631872
99MP0005636_abnormal_mineral_homeostasis1.04400543
100MP0001529_abnormal_vocalization1.04314986
101MP0002751_abnormal_autonomic_nervous1.04094536
102MP0005319_abnormal_enzyme/_coenzyme1.03384342
103MP0002019_abnormal_tumor_incidence1.02666135
104MP0010329_abnormal_lipoprotein_level1.02468076
105MP0002210_abnormal_sex_determination1.02164136
106MP0001293_anophthalmia1.02154204
107MP0005220_abnormal_exocrine_pancreas1.01752539
108MP0002163_abnormal_gland_morphology1.01361847
109MP0000313_abnormal_cell_death1.01220332
110MP0001697_abnormal_embryo_size1.00436459
111MP0002272_abnormal_nervous_system0.99964136
112MP0000703_abnormal_thymus_morphology0.99458567
113MP0008932_abnormal_embryonic_tissue0.98299306
114MP0009697_abnormal_copulation0.98197564
115MP0003137_abnormal_impulse_conducting0.97206921
116MP0002106_abnormal_muscle_physiology0.96119777
117MP0002693_abnormal_pancreas_physiology0.95647389
118MP0001666_abnormal_nutrient_absorption0.95492398
119MP0002970_abnormal_white_adipose0.94289691
120MP0002234_abnormal_pharynx_morphology0.94276923
121MP0002160_abnormal_reproductive_system0.93830203
122MP0000516_abnormal_urinary_system0.93094716
123MP0005367_renal/urinary_system_phenotyp0.93094716
124MP0002429_abnormal_blood_cell0.92623533
125MP0005410_abnormal_fertilization0.91597144
126MP0000598_abnormal_liver_morphology0.90637039
127MP0006292_abnormal_olfactory_placode0.90296487
128MP0003121_genomic_imprinting0.89729582
129MP0000653_abnormal_sex_gland0.89335340
130MP0002166_altered_tumor_susceptibility0.88693156
131MP0000350_abnormal_cell_proliferation0.88634836
132MP0002078_abnormal_glucose_homeostasis0.87977976
133MP0000685_abnormal_immune_system0.87812149
134MP0010630_abnormal_cardiac_muscle0.87645573
135MP0003123_paternal_imprinting0.87458135
136MP0003698_abnormal_male_reproductive0.86922323
137MP0008995_early_reproductive_senescence0.86606823
138MP0001544_abnormal_cardiovascular_syste0.86302348
139MP0005385_cardiovascular_system_phenoty0.86302348
140MP0009745_abnormal_behavioral_response0.86236795
141MP0002557_abnormal_social/conspecific_i0.85710477
142MP0001145_abnormal_male_reproductive0.85467190
143MP0008775_abnormal_heart_ventricle0.85338932
144MP0002090_abnormal_vision0.85154118
145MP0004043_abnormal_pH_regulation0.84934511
146MP0003984_embryonic_growth_retardation0.84775128
147MP0003943_abnormal_hepatobiliary_system0.84649354
148MP0005195_abnormal_posterior_eye0.84503001
149MP0005670_abnormal_white_adipose0.84228108
150MP0003866_abnormal_defecation0.83799137
151MP0005464_abnormal_platelet_physiology0.83503315
152MP0005391_vision/eye_phenotype0.83158450
153MP0001944_abnormal_pancreas_morphology0.82904010
154MP0009643_abnormal_urine_homeostasis0.82728597
155MP0002088_abnormal_embryonic_growth/wei0.81807694
156MP0003252_abnormal_bile_duct0.81766901
157MP0000049_abnormal_middle_ear0.81134918
158MP0002229_neurodegeneration0.81127472
159MP0005380_embryogenesis_phenotype0.78561747
160MP0001672_abnormal_embryogenesis/_devel0.78561747
161MP0003880_abnormal_central_pattern0.78250847
162MP0004087_abnormal_muscle_fiber0.78066728
163MP0005671_abnormal_response_to0.77888869
164MP0006138_congestive_heart_failure0.77556002
165MP0002095_abnormal_skin_pigmentation0.77481808
166MP0005083_abnormal_biliary_tract0.76136651
167MP0000026_abnormal_inner_ear0.75943577

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.69366888
2Abnormality of cells of the erythroid lineage (HP:0012130)4.49212626
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.00265627
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.00265627
5Hepatic necrosis (HP:0002605)3.99806166
6Abnormality of the heme biosynthetic pathway (HP:0010472)3.89760465
7Hepatocellular necrosis (HP:0001404)3.88590158
8Ragged-red muscle fibers (HP:0003200)3.42326532
9Abnormal mitochondria in muscle tissue (HP:0008316)3.32418374
10Progressive muscle weakness (HP:0003323)3.29383800
11Thrombocytosis (HP:0001894)3.28848378
12Increased CSF lactate (HP:0002490)3.28537121
13Lactic acidosis (HP:0003128)3.27515274
14Increased serum lactate (HP:0002151)3.20604962
15Abnormality of alanine metabolism (HP:0010916)3.17763504
16Hyperalaninemia (HP:0003348)3.17763504
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17763504
18Abnormality of midbrain morphology (HP:0002418)3.07899877
19Molar tooth sign on MRI (HP:0002419)3.07899877
20Rhabdomyolysis (HP:0003201)3.06746563
21Dicarboxylic aciduria (HP:0003215)3.05965189
22Abnormality of dicarboxylic acid metabolism (HP:0010995)3.05965189
23Mitochondrial inheritance (HP:0001427)3.03879552
24Increased muscle lipid content (HP:0009058)3.02119312
25Acute necrotizing encephalopathy (HP:0006965)3.01226987
26Reduced antithrombin III activity (HP:0001976)3.00531689
27Methylmalonic acidemia (HP:0002912)2.98349664
28True hermaphroditism (HP:0010459)2.97241130
29Acute encephalopathy (HP:0006846)2.95163745
30Aplastic anemia (HP:0001915)2.93182169
31Pancreatic cysts (HP:0001737)2.91584103
32Chronic otitis media (HP:0000389)2.81709761
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81487395
34Hypoglycemic coma (HP:0001325)2.80837768
35Increased intramyocellular lipid droplets (HP:0012240)2.80458968
36Myoglobinuria (HP:0002913)2.77218932
37Abnormality of fatty-acid metabolism (HP:0004359)2.71626206
38IgM deficiency (HP:0002850)2.69743713
39Respiratory difficulties (HP:0002880)2.69395384
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67155397
41Cerebral edema (HP:0002181)2.66737991
42Renal Fanconi syndrome (HP:0001994)2.65595423
43Reticulocytopenia (HP:0001896)2.63882247
44Ketosis (HP:0001946)2.63140439
45Hyperbilirubinemia (HP:0002904)2.61810918
46Pancreatic fibrosis (HP:0100732)2.61678629
47Retinal dysplasia (HP:0007973)2.61172135
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60363238
49Lipid accumulation in hepatocytes (HP:0006561)2.59615368
50Hyperglycinemia (HP:0002154)2.58908998
51Hyperammonemia (HP:0001987)2.57954355
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.57477171
53Abnormal protein N-linked glycosylation (HP:0012347)2.57477171
54Abnormal protein glycosylation (HP:0012346)2.57477171
55Abnormal glycosylation (HP:0012345)2.57477171
56Type I transferrin isoform profile (HP:0003642)2.56837782
57Optic disc pallor (HP:0000543)2.54273158
58Late onset (HP:0003584)2.53915661
59Medial flaring of the eyebrow (HP:0010747)2.52360750
60Abnormality of serine family amino acid metabolism (HP:0010894)2.48162924
61Abnormality of glycine metabolism (HP:0010895)2.48162924
62CNS demyelination (HP:0007305)2.47737546
63Cerebral hypomyelination (HP:0006808)2.43471369
6411 pairs of ribs (HP:0000878)2.43223618
65Abnormality of the labia minora (HP:0012880)2.42263159
66Type II lissencephaly (HP:0007260)2.38139660
67Hypoplasia of the thymus (HP:0000778)2.35081303
68Generalized aminoaciduria (HP:0002909)2.32964684
69Increased serum pyruvate (HP:0003542)2.31669536
70Abnormality of glycolysis (HP:0004366)2.31669536
71Exercise intolerance (HP:0003546)2.31247066
72Emotional lability (HP:0000712)2.30958822
73Sclerocornea (HP:0000647)2.30820375
74Nephronophthisis (HP:0000090)2.25811437
75Hypoplasia of the pons (HP:0012110)2.25463707
76Ketoacidosis (HP:0001993)2.24647710
77Abnormality of the pons (HP:0007361)2.24140279
78Lethargy (HP:0001254)2.23657393
79Increased hepatocellular lipid droplets (HP:0006565)2.23650639
80Abnormality of serum amino acid levels (HP:0003112)2.23162501
81Hyperglycinuria (HP:0003108)2.22162284
82Pancreatic islet-cell hyperplasia (HP:0004510)2.21460674
83Panhypogammaglobulinemia (HP:0003139)2.19056719
84Gait imbalance (HP:0002141)2.17805978
85Progressive microcephaly (HP:0000253)2.16336669
86Progressive macrocephaly (HP:0004481)2.16168435
87Congenital primary aphakia (HP:0007707)2.15166507
88Methylmalonic aciduria (HP:0012120)2.14776986
89Nephrogenic diabetes insipidus (HP:0009806)2.13231208
90Limb hypertonia (HP:0002509)2.11662644
91Recurrent bronchitis (HP:0002837)2.10739848
92Abolished electroretinogram (ERG) (HP:0000550)2.10454137
93Type 2 muscle fiber atrophy (HP:0003554)2.08297378
94Brushfield spots (HP:0001088)2.08019668
95Postnatal microcephaly (HP:0005484)2.07522037
96Pallor (HP:0000980)2.06845958
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06534860
98Macrocytic anemia (HP:0001972)2.06318687
99Oral leukoplakia (HP:0002745)2.02234255
100Microvesicular hepatic steatosis (HP:0001414)2.02138597
101Congenital stationary night blindness (HP:0007642)2.01109592
102Abnormality of the pancreatic islet cells (HP:0006476)1.99612835
103Abnormality of endocrine pancreas physiology (HP:0012093)1.99612835
104Palpitations (HP:0001962)1.99531427
105CNS hypomyelination (HP:0003429)1.96897651
106Gliosis (HP:0002171)1.96281965
1073-Methylglutaconic aciduria (HP:0003535)1.95425301
108Poor suck (HP:0002033)1.94899064
109Abnormal rod and cone electroretinograms (HP:0008323)1.92807386
110Severe visual impairment (HP:0001141)1.92060187
111Neuroendocrine neoplasm (HP:0100634)1.92010216
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91681871
113Respiratory failure (HP:0002878)1.91117108
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.90320929
115Meckel diverticulum (HP:0002245)1.89811281
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89266231
117Colon cancer (HP:0003003)1.89091876
118Anencephaly (HP:0002323)1.88830846
119Hypobetalipoproteinemia (HP:0003563)1.88687992
120Abnormality of the ileum (HP:0001549)1.87907693
121Leukodystrophy (HP:0002415)1.87283113
122Metabolic acidosis (HP:0001942)1.86144832
123Severe muscular hypotonia (HP:0006829)1.86065127
124Large for gestational age (HP:0001520)1.85178591
125Male pseudohermaphroditism (HP:0000037)1.84090964
126Muscle fiber atrophy (HP:0100295)1.82531869
127Abnormality of reticulocytes (HP:0004312)1.82434248
128Chronic hepatic failure (HP:0100626)1.81896986
129Absent thumb (HP:0009777)1.81599133
130Constricted visual fields (HP:0001133)1.80950420
131Pheochromocytoma (HP:0002666)1.80419949
132Exertional dyspnea (HP:0002875)1.79623860
133Concave nail (HP:0001598)1.79600962
134Attenuation of retinal blood vessels (HP:0007843)1.78983543
135Renal cortical cysts (HP:0000803)1.78370195
136Gout (HP:0001997)1.76735824
137Unsteady gait (HP:0002317)1.76128738
138Abnormal biliary tract physiology (HP:0012439)1.75758604
139Bile duct proliferation (HP:0001408)1.75758604
140Intrahepatic cholestasis (HP:0001406)1.75304828
141Multiple enchondromatosis (HP:0005701)1.74887651
142Abnormality of renal resorption (HP:0011038)1.74445925
143Neoplasm of the adrenal gland (HP:0100631)1.69165598
144Abnormality of B cell number (HP:0010975)1.66915174
145B lymphocytopenia (HP:0010976)1.66915174
146Pancytopenia (HP:0001876)1.65681825
147Poikiloderma (HP:0001029)1.64558998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.69148555
2STK163.79861659
3EIF2AK13.33164492
4NUAK13.08115284
5WEE13.06495712
6BUB13.01045902
7BCKDK2.97794047
8FLT32.93979546
9EEF2K2.65123955
10INSRR2.64844545
11PDK42.58712886
12PDK32.58712886
13VRK22.58345934
14ZAK2.54751992
15PKN22.48179126
16TRIM282.28642052
17MAP4K22.23495067
18TNIK2.17709161
19WNK32.16697492
20TLK12.13303873
21MAP4K12.04179379
22CCNB12.03243517
23NEK11.92844784
24BRSK21.79502660
25DYRK31.76497405
26CDC71.71983085
27TRIB31.71834759
28EIF2AK31.66113340
29SRPK11.65629648
30TGFBR11.60312830
31BTK1.55621209
32DYRK21.55197496
33GRK11.55044869
34KIT1.52809653
35FRK1.52488193
36PIM21.46786068
37TIE11.44251280
38TEC1.40657733
39NEK21.39633743
40VRK11.39375276
41MAP2K71.38043528
42MAP3K41.35034160
43MST41.32527817
44SCYL21.29966573
45CDK191.26543964
46STK391.25267986
47BMPR1B1.24637063
48RPS6KB21.24183954
49CSNK1G11.18074233
50MAP3K101.16329663
51MAP2K31.15331492
52MUSK1.11514609
53NME21.09035571
54MKNK21.06941842
55LRRK21.06447111
56BRSK11.06290043
57ACVR1B1.06139000
58CSNK1G21.04406444
59OXSR11.02920640
60CDK71.02279763
61ATR1.01808345
62CSNK1A1L1.00351534
63ZAP700.99837185
64MAP3K120.99431960
65TSSK60.96633469
66CSF1R0.96322601
67CAMKK10.94768003
68CDK40.93283119
69TESK20.92134147
70AURKB0.90706331
71MAPK130.89656653
72RAF10.87639028
73MAPK110.87459472
74PLK10.87020156
75MYLK0.83559287
76OBSCN0.83450976
77MKNK10.83270720
78ERBB30.83100238
79LIMK10.83047770
80SYK0.77883021
81TGFBR20.75929017
82PRKCG0.74852431
83RPS6KA50.73172692
84PAK40.72331065
85BCR0.70093740
86PBK0.69019374
87EIF2AK20.68550213
88CASK0.68438384
89KDR0.67624574
90MAP3K80.66491414
91LATS10.65702799
92PIK3CG0.65461413
93ILK0.64820836
94ITK0.64514958
95TTN0.64121698
96PDK20.63812709
97MAPKAPK30.62896174
98TTK0.61696244
99CHEK20.60483022
100KSR10.59293263
101RPS6KA40.58996653
102TXK0.58352256
103PRKCE0.58199066
104GRK60.58106706
105MAPK150.56962800
106AKT20.56351212
107MAP3K110.54634117
108MAP2K60.54537536
109STK38L0.51766528
110PLK40.51447085
111STK100.50992617
112MAPKAPK50.50835498
113STK40.49900668
114ADRBK10.48887806
115CSNK1A10.47517724
116CDK30.46177357
117CHEK10.46031350
118PRKCI0.45141054
119TYK20.44656328
120PLK20.44510520
121CAMK10.44371604
122IKBKB0.43391831
123ATM0.42743623
124CSNK1G30.41685874
125CLK10.39323064
126WNK40.38795767
127PLK30.38419676
128PRKCQ0.38121809
129CSNK2A20.37794379
130PRKACA0.37012363
131STK240.36965490
132CDK80.35425440
133PIM10.35360174
134CAMKK20.34844047
135PNCK0.34531395
136PHKG10.32997303
137PHKG20.32997303
138ABL20.32144737
139PAK30.31921081
140LYN0.30419272
141MAPK40.30414853
142NME10.30312802
143MAPK120.29202853
144DAPK10.28559086
145PINK10.28486982
146CDK20.27917990
147CSNK2A10.27698711
148ICK0.26863086
149PRKG20.26719469
150ADRBK20.25417665
151LCK0.25400877
152AURKA0.23689420
153YES10.22386987
154HIPK20.21165121

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.90538268
2DNA replication_Homo sapiens_hsa030303.59317094
3Ribosome_Homo sapiens_hsa030103.06510775
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.77082564
5Mismatch repair_Homo sapiens_hsa034302.36798175
6Proteasome_Homo sapiens_hsa030502.22689066
7Base excision repair_Homo sapiens_hsa034102.22553686
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18277660
9Carbon metabolism_Homo sapiens_hsa012002.17976242
10Spliceosome_Homo sapiens_hsa030402.17489881
11Pyrimidine metabolism_Homo sapiens_hsa002402.14042151
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10230824
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08980767
14Propanoate metabolism_Homo sapiens_hsa006402.05273027
15Biosynthesis of amino acids_Homo sapiens_hsa012301.98477678
16RNA polymerase_Homo sapiens_hsa030201.93590171
17One carbon pool by folate_Homo sapiens_hsa006701.88847950
18Pentose phosphate pathway_Homo sapiens_hsa000301.87590232
19RNA transport_Homo sapiens_hsa030131.87555748
20Selenocompound metabolism_Homo sapiens_hsa004501.87189127
21Fatty acid degradation_Homo sapiens_hsa000711.86782500
22Pyruvate metabolism_Homo sapiens_hsa006201.79125765
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76195905
24Parkinsons disease_Homo sapiens_hsa050121.70777432
25Folate biosynthesis_Homo sapiens_hsa007901.69350581
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66244871
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64676430
28Fatty acid metabolism_Homo sapiens_hsa012121.58437407
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.56015693
30Nucleotide excision repair_Homo sapiens_hsa034201.53719330
31Homologous recombination_Homo sapiens_hsa034401.52870786
32Sulfur relay system_Homo sapiens_hsa041221.48625306
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.44002115
34Protein export_Homo sapiens_hsa030601.43951663
35Oxidative phosphorylation_Homo sapiens_hsa001901.37831504
36Fatty acid elongation_Homo sapiens_hsa000621.32512834
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31651628
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31518037
39Steroid biosynthesis_Homo sapiens_hsa001001.31508662
40RNA degradation_Homo sapiens_hsa030181.30211946
41Non-homologous end-joining_Homo sapiens_hsa034501.27988677
42Purine metabolism_Homo sapiens_hsa002301.26972736
43N-Glycan biosynthesis_Homo sapiens_hsa005101.25048097
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25028600
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23868657
46Cell cycle_Homo sapiens_hsa041101.22488886
47Vitamin B6 metabolism_Homo sapiens_hsa007501.19409958
48Phototransduction_Homo sapiens_hsa047441.19373145
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13518938
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.12766201
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10819671
52Huntingtons disease_Homo sapiens_hsa050161.10337833
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.08919181
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98451719
55Tryptophan metabolism_Homo sapiens_hsa003800.97500026
56Peroxisome_Homo sapiens_hsa041460.96122071
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91977179
58Linoleic acid metabolism_Homo sapiens_hsa005910.89155071
59Nitrogen metabolism_Homo sapiens_hsa009100.88449514
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87749265
61Primary immunodeficiency_Homo sapiens_hsa053400.86244698
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85599494
63Systemic lupus erythematosus_Homo sapiens_hsa053220.83193666
64Alzheimers disease_Homo sapiens_hsa050100.82807633
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82305800
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.81235692
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81063813
68Arginine and proline metabolism_Homo sapiens_hsa003300.80194905
69Butanoate metabolism_Homo sapiens_hsa006500.79302804
70beta-Alanine metabolism_Homo sapiens_hsa004100.78995752
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77743484
72Fructose and mannose metabolism_Homo sapiens_hsa000510.76801463
73Metabolic pathways_Homo sapiens_hsa011000.76695772
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76039636
75mRNA surveillance pathway_Homo sapiens_hsa030150.75576169
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75446671
77Chemical carcinogenesis_Homo sapiens_hsa052040.74183424
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73243943
79Cardiac muscle contraction_Homo sapiens_hsa042600.73034706
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72287332
81Sulfur metabolism_Homo sapiens_hsa009200.71519348
82Basal transcription factors_Homo sapiens_hsa030220.70963703
83Collecting duct acid secretion_Homo sapiens_hsa049660.65565302
84Galactose metabolism_Homo sapiens_hsa000520.60819688
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59390567
86Fanconi anemia pathway_Homo sapiens_hsa034600.58943842
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57502682
88Ether lipid metabolism_Homo sapiens_hsa005650.56880850
89Regulation of autophagy_Homo sapiens_hsa041400.55682226
90Starch and sucrose metabolism_Homo sapiens_hsa005000.55107979
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54697262
92Lysine degradation_Homo sapiens_hsa003100.51342044
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.50761631
94Thyroid cancer_Homo sapiens_hsa052160.49801062
95Glutathione metabolism_Homo sapiens_hsa004800.49140892
96Arachidonic acid metabolism_Homo sapiens_hsa005900.47062030
97ABC transporters_Homo sapiens_hsa020100.47024661
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47019668
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.46878441
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46127084
101Vitamin digestion and absorption_Homo sapiens_hsa049770.43212222
102Caffeine metabolism_Homo sapiens_hsa002320.41385366
103p53 signaling pathway_Homo sapiens_hsa041150.41374950
104Retinol metabolism_Homo sapiens_hsa008300.40750430
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.40652462
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40297629
107Nicotine addiction_Homo sapiens_hsa050330.40206587
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39869884
109Antigen processing and presentation_Homo sapiens_hsa046120.38327328
110Type I diabetes mellitus_Homo sapiens_hsa049400.38149803
111PPAR signaling pathway_Homo sapiens_hsa033200.37882873
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35998776
113Epstein-Barr virus infection_Homo sapiens_hsa051690.35732718
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35247316
115Glucagon signaling pathway_Homo sapiens_hsa049220.34104067
116Asthma_Homo sapiens_hsa053100.33350386
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32688812
118Olfactory transduction_Homo sapiens_hsa047400.32144387
119Fat digestion and absorption_Homo sapiens_hsa049750.29835037
120Arginine biosynthesis_Homo sapiens_hsa002200.29526021
121Viral carcinogenesis_Homo sapiens_hsa052030.28415644
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26160537
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23750589
124Alcoholism_Homo sapiens_hsa050340.21960157
125Herpes simplex infection_Homo sapiens_hsa051680.21956765
126Fatty acid biosynthesis_Homo sapiens_hsa000610.20296413
127Oocyte meiosis_Homo sapiens_hsa041140.19924024

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