TMEM187

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.26516881
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.26516881
3purine nucleotide salvage (GO:0032261)5.77945414
4nucleotide salvage (GO:0043173)5.35666459
5sulfur amino acid catabolic process (GO:0000098)5.32695251
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.82026405
7galactose catabolic process (GO:0019388)4.71825308
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.28990469
9pyrimidine nucleotide catabolic process (GO:0006244)3.99057535
10folic acid-containing compound biosynthetic process (GO:0009396)3.98752570
11galactose metabolic process (GO:0006012)3.89412577
12negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.87914004
13regulation of plasminogen activation (GO:0010755)3.75529905
14negative regulation of epidermal cell differentiation (GO:0045605)3.66448601
15deoxyribonucleotide catabolic process (GO:0009264)3.62362946
16serine family amino acid biosynthetic process (GO:0009070)3.57817162
17homocysteine metabolic process (GO:0050667)3.57634965
18protein maturation by protein folding (GO:0022417)3.55090856
19negative regulation of transcription by competitive promoter binding (GO:0010944)3.53941071
20deoxyribose phosphate catabolic process (GO:0046386)3.52763774
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50363456
22pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.44408932
23pteridine-containing compound biosynthetic process (GO:0042559)3.39482825
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.35624433
25NADH dehydrogenase complex assembly (GO:0010257)3.35624433
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35624433
27adenine nucleotide transport (GO:0051503)3.33688227
28purine ribonucleotide transport (GO:0015868)3.33643855
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32286338
30ATP synthesis coupled proton transport (GO:0015986)3.32286338
31guanosine-containing compound biosynthetic process (GO:1901070)3.28141779
32purine-containing compound salvage (GO:0043101)3.26677875
33viral transcription (GO:0019083)3.23767595
34white fat cell differentiation (GO:0050872)3.20809926
35glycoside metabolic process (GO:0016137)3.17911547
36nucleoside transport (GO:0015858)3.16974510
37negative regulation of epidermis development (GO:0045683)3.16715905
38aminoglycoside antibiotic metabolic process (GO:0030647)3.15734109
39polyamine metabolic process (GO:0006595)3.13549962
40lipopolysaccharide biosynthetic process (GO:0009103)3.12445266
41ATP hydrolysis coupled proton transport (GO:0015991)3.12290354
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.12290354
43cysteine metabolic process (GO:0006534)3.11654415
44cellular metabolic compound salvage (GO:0043094)3.09479262
45protein complex biogenesis (GO:0070271)3.09418678
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.09196259
47GTP biosynthetic process (GO:0006183)3.09187823
48nucleoside transmembrane transport (GO:1901642)3.06469851
49L-serine metabolic process (GO:0006563)3.04102184
50base-excision repair, AP site formation (GO:0006285)3.03053161
51purine deoxyribonucleotide catabolic process (GO:0009155)3.00416335
52mannosylation (GO:0097502)2.96292142
53translational termination (GO:0006415)2.92578609
54protein localization to endoplasmic reticulum (GO:0070972)2.92006269
55epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.91919343
56negative regulation of Notch signaling pathway (GO:0045746)2.91627070
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90497789
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89516188
59GDP-mannose metabolic process (GO:0019673)2.87593366
60protein targeting to ER (GO:0045047)2.85907229
61cotranslational protein targeting to membrane (GO:0006613)2.85520567
62negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.84537061
63nucleoside salvage (GO:0043174)2.79879285
64virion assembly (GO:0019068)2.79187340
65rRNA modification (GO:0000154)2.78567704
66pentose metabolic process (GO:0019321)2.78503464
67viral protein processing (GO:0019082)2.78208009
68mitochondrial respiratory chain complex assembly (GO:0033108)2.78174816
69peptidyl-histidine modification (GO:0018202)2.77691247
70desmosome organization (GO:0002934)2.77077063
71electron transport chain (GO:0022900)2.76485858
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.76175256
73peptidyl-arginine omega-N-methylation (GO:0035247)2.74014046
74respiratory electron transport chain (GO:0022904)2.72133850
752-deoxyribonucleotide metabolic process (GO:0009394)2.72058103
76translational elongation (GO:0006414)2.71744577
77UTP biosynthetic process (GO:0006228)2.67142333
78establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66725843
79platelet dense granule organization (GO:0060155)2.66270850
80rRNA methylation (GO:0031167)2.63981016
81adenosine metabolic process (GO:0046085)2.62713981
82amyloid precursor protein catabolic process (GO:0042987)2.62325365
83positive regulation of translational initiation (GO:0045948)2.62242837
84heme biosynthetic process (GO:0006783)2.61993212
854-hydroxyproline metabolic process (GO:0019471)2.61020854
86glycosphingolipid catabolic process (GO:0046479)2.59994123
87carbohydrate derivative transport (GO:1901264)2.59401788
88deoxyribose phosphate metabolic process (GO:0019692)2.59104465
89lipopolysaccharide metabolic process (GO:0008653)2.58892558
90pyrimidine nucleoside biosynthetic process (GO:0046134)2.58472700
91purine nucleotide transport (GO:0015865)2.58163215
92protein retention in ER lumen (GO:0006621)2.56557604
93ubiquinone biosynthetic process (GO:0006744)2.56221025
94sequestering of actin monomers (GO:0042989)2.52643295
95regulation of release of cytochrome c from mitochondria (GO:0090199)2.52395829
96oxidative phosphorylation (GO:0006119)2.51968676
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51807950
98viral life cycle (GO:0019058)2.51362025
99polyamine biosynthetic process (GO:0006596)2.50221004
100negative regulation of Ras GTPase activity (GO:0034261)2.49605294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.21786289
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.84977276
3ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95229392
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92420486
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89584241
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79119509
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59572088
8ZNF263_19887448_ChIP-Seq_K562_Human2.53622430
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25510679
10CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.25441659
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23219081
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.16261165
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14952058
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.08241675
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07875116
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.02835533
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.01504363
18XRN2_22483619_ChIP-Seq_HELA_Human1.97228099
19CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.90406949
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84977528
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81933156
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79296587
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78705915
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78109690
25GABP_19822575_ChIP-Seq_HepG2_Human1.75247798
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73724020
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.73164746
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72729741
29VDR_21846776_ChIP-Seq_THP-1_Human1.68728467
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.68466313
31LXR_22292898_ChIP-Seq_THP-1_Human1.66970295
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64396584
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.60380374
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57485806
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54826306
36BCL6_27268052_Chip-Seq_Bcells_Human1.51925936
37CTCF_18555785_ChIP-Seq_MESCs_Mouse1.51167119
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49139266
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47440904
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46763415
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.46045425
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43557135
43P68_20966046_ChIP-Seq_HELA_Human1.43469158
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42223217
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41842902
46BCOR_27268052_Chip-Seq_Bcells_Human1.38193845
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35366682
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.34884512
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34386065
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32130859
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32022934
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31706183
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29154798
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28485507
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.28175829
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24655554
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23747521
58FOXP3_21729870_ChIP-Seq_TREG_Human1.23603933
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23450411
60SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21957722
61CTCF_26484167_Chip-Seq_Bcells_Mouse1.21840016
62DCP1A_22483619_ChIP-Seq_HELA_Human1.21473468
63RACK7_27058665_Chip-Seq_MCF-7_Human1.19745053
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19183181
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.18829084
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.18591218
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18479968
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18444998
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.18181777
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18003935
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17370581
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17147520
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16787376
74TBX5_21415370_ChIP-Seq_HL-1_Mouse1.16574241
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11724963
76VDR_23849224_ChIP-Seq_CD4+_Human1.11578919
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11213470
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.08681604
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.08321144
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08015664
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06332179
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04839690
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04577043
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04496937
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01858822
86KDM5A_27292631_Chip-Seq_BREAST_Human1.01810849
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98886123
88NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98779697
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97573931
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97425298
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97013646
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97004928
93E2F1_20622854_ChIP-Seq_HELA_Human0.95311256
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93427049
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93340932
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93273264
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92735888
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92327614
99RARA_24833708_ChIP-Seq_LIVER_Mouse0.91994582
100TTF2_22483619_ChIP-Seq_HELA_Human0.91992695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.03011720
2MP0005058_abnormal_lysosome_morphology3.92348075
3MP0003806_abnormal_nucleotide_metabolis3.52809328
4MP0008789_abnormal_olfactory_epithelium3.37128813
5MP0005670_abnormal_white_adipose3.21378579
6MP0005394_taste/olfaction_phenotype2.97977805
7MP0005499_abnormal_olfactory_system2.97977805
8MP0010030_abnormal_orbit_morphology2.92463839
9MP0005360_urolithiasis2.83361378
10MP0001661_extended_life_span2.61929195
11MP0002234_abnormal_pharynx_morphology2.50749509
12MP0009379_abnormal_foot_pigmentation2.44717251
13MP0003186_abnormal_redox_activity2.30973421
14MP0003705_abnormal_hypodermis_morpholog2.21507878
15MP0000003_abnormal_adipose_tissue2.21094034
16MP0008995_early_reproductive_senescence2.13796456
17MP0006292_abnormal_olfactory_placode2.06546582
18MP0001764_abnormal_homeostasis1.93931515
19MP0002938_white_spotting1.88130053
20MP0000678_abnormal_parathyroid_gland1.77923093
21MP0004233_abnormal_muscle_weight1.71649761
22MP0000372_irregular_coat_pigmentation1.70068376
23MP0000013_abnormal_adipose_tissue1.65565681
24MP0001664_abnormal_digestion1.58279868
25MP0004147_increased_porphyrin_level1.54405431
26MP0003786_premature_aging1.51753877
27MP0008875_abnormal_xenobiotic_pharmacok1.50505248
28MP0003011_delayed_dark_adaptation1.48529289
29MP0005257_abnormal_intraocular_pressure1.46933838
30MP0000750_abnormal_muscle_regeneration1.46383526
31MP0006036_abnormal_mitochondrial_physio1.45864282
32MP0000343_altered_response_to1.43963731
33MP0003136_yellow_coat_color1.37469876
34MP0000490_abnormal_crypts_of1.36148794
35MP0002249_abnormal_larynx_morphology1.34922774
36MP0009697_abnormal_copulation1.34287128
37MP0009785_altered_susceptibility_to1.20982974
38MP0002132_abnormal_respiratory_system1.20262917
39MP0003191_abnormal_cellular_cholesterol1.18284799
40MP0005381_digestive/alimentary_phenotyp1.17796795
41MP0001663_abnormal_digestive_system1.17224723
42MP0005332_abnormal_amino_acid1.17139853
43MP0000538_abnormal_urinary_bladder1.12881065
44MP0009053_abnormal_anal_canal1.12063029
45MP0002148_abnormal_hypersensitivity_rea1.11684848
46MP0003938_abnormal_ear_development1.10200234
47MP0000467_abnormal_esophagus_morphology1.07396415
48MP0003724_increased_susceptibility_to1.05440429
49MP0001542_abnormal_bone_strength1.05349042
50MP0009840_abnormal_foam_cell1.04665180
51MP0000462_abnormal_digestive_system1.01386820
52MP0000383_abnormal_hair_follicle0.99275699
53MP0005165_increased_susceptibility_to0.98090780
54MP0002277_abnormal_respiratory_mucosa0.97534371
55MP0000049_abnormal_middle_ear0.97298665
56MP0005375_adipose_tissue_phenotype0.97186063
57MP0000681_abnormal_thyroid_gland0.97141600
58MP0002295_abnormal_pulmonary_circulatio0.97037216
59MP0004185_abnormal_adipocyte_glucose0.96004387
60MP0002095_abnormal_skin_pigmentation0.95731586
61MP0003183_abnormal_peptide_metabolism0.93418425
62MP0005083_abnormal_biliary_tract0.93061487
63MP0001905_abnormal_dopamine_level0.90301126
64MP0009333_abnormal_splenocyte_physiolog0.89826496
65MP0001529_abnormal_vocalization0.89450997
66MP0000566_synostosis0.87973596
67MP0002098_abnormal_vibrissa_morphology0.84254244
68MP0000026_abnormal_inner_ear0.81904576
69MP0008961_abnormal_basal_metabolism0.80964232
70MP0005666_abnormal_adipose_tissue0.78933741
71MP0000762_abnormal_tongue_morphology0.78630604
72MP0000516_abnormal_urinary_system0.78277988
73MP0005367_renal/urinary_system_phenotyp0.78277988
74MP0009643_abnormal_urine_homeostasis0.77427719
75MP0002282_abnormal_trachea_morphology0.77141129
76MP0000470_abnormal_stomach_morphology0.77122283
77MP0003942_abnormal_urinary_system0.75168556
78MP0000858_altered_metastatic_potential0.75164245
79MP0008469_abnormal_protein_level0.74098372
80MP0000534_abnormal_ureter_morphology0.74084391
81MP0005193_abnormal_anterior_eye0.73902654
82MP0009765_abnormal_xenobiotic_induced0.72657619
83MP0001756_abnormal_urination0.72268917
84MP0009764_decreased_sensitivity_to0.71751911
85MP0004858_abnormal_nervous_system0.71058551
86MP0002736_abnormal_nociception_after0.70913479
87MP0002932_abnormal_joint_morphology0.69344154
88MP0000358_abnormal_cell_content/0.69203553
89MP0009278_abnormal_bone_marrow0.68425472
90MP0008004_abnormal_stomach_pH0.68279269
91MP0001727_abnormal_embryo_implantation0.67370587
92MP0002909_abnormal_adrenal_gland0.65138190
93MP0001845_abnormal_inflammatory_respons0.64864723
94MP0002638_abnormal_pupillary_reflex0.64854360
95MP0006035_abnormal_mitochondrial_morpho0.62997229
96MP0005584_abnormal_enzyme/coenzyme_acti0.62579296
97MP0005451_abnormal_body_composition0.60560250
98MP0001243_abnormal_dermal_layer0.59893266
99MP0005646_abnormal_pituitary_gland0.59877334
100MP0001502_abnormal_circadian_rhythm0.59310999

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)4.20128501
2Hyperalaninemia (HP:0003348)4.20128501
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.20128501
4Abnormality of glycolipid metabolism (HP:0010969)3.76181546
5Abnormality of liposaccharide metabolism (HP:0010968)3.76181546
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.76181546
7Hepatocellular necrosis (HP:0001404)3.45060578
8Abnormal mitochondria in muscle tissue (HP:0008316)3.34675115
9Microretrognathia (HP:0000308)3.28886269
10Prolonged neonatal jaundice (HP:0006579)3.11793437
11Hypoplastic left heart (HP:0004383)3.06639751
12Hepatic necrosis (HP:0002605)3.03263881
13Acute necrotizing encephalopathy (HP:0006965)3.02160753
14Median cleft lip (HP:0000161)2.97444754
15Mitochondrial inheritance (HP:0001427)2.88884808
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.88552398
17Spontaneous hematomas (HP:0007420)2.86528777
18Generalized aminoaciduria (HP:0002909)2.85395896
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83075467
20Acute encephalopathy (HP:0006846)2.82601988
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77624680
22Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77624680
23Hypertensive crisis (HP:0100735)2.75140229
24Beaking of vertebral bodies (HP:0004568)2.72824618
25Constricted visual fields (HP:0001133)2.66680507
26Lactic acidosis (HP:0003128)2.59552024
27Systemic lupus erythematosus (HP:0002725)2.53120828
28Vacuolated lymphocytes (HP:0001922)2.51141296
29Type I transferrin isoform profile (HP:0003642)2.45916466
30Short nail (HP:0001799)2.43772942
31Cortical visual impairment (HP:0100704)2.41387612
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40352166
33Abnormal protein N-linked glycosylation (HP:0012347)2.40352166
34Abnormal protein glycosylation (HP:0012346)2.40352166
35Abnormal glycosylation (HP:0012345)2.40352166
36White forelock (HP:0002211)2.37801838
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37764648
38Thoracic kyphosis (HP:0002942)2.36710806
39Increased intramyocellular lipid droplets (HP:0012240)2.33133980
40Increased muscle lipid content (HP:0009058)2.30511357
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30384486
42Increased CSF lactate (HP:0002490)2.30358526
43Myopathic facies (HP:0002058)2.29812707
44Abnormality of fatty-acid metabolism (HP:0004359)2.29486350
45Vertebral compression fractures (HP:0002953)2.27292780
46Oligomenorrhea (HP:0000876)2.26539573
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.25961071
48Increased serum lactate (HP:0002151)2.24517391
49Patchy hypopigmentation of hair (HP:0011365)2.22263616
50Progressive macrocephaly (HP:0004481)2.21621610
51Esophageal varix (HP:0002040)2.20912314
52Hypoplastic heart (HP:0001961)2.19603263
53Hyperammonemia (HP:0001987)2.17002742
54Exercise intolerance (HP:0003546)2.14166234
553-Methylglutaconic aciduria (HP:0003535)2.13343050
56Sclerocornea (HP:0000647)2.12698821
57Congenital ichthyosiform erythroderma (HP:0007431)2.12640342
58Biconcave vertebral bodies (HP:0004586)2.11750248
59Abnormality of the fetal cardiovascular system (HP:0010948)2.11425532
60Abnormal umbilical cord blood vessels (HP:0011403)2.11425532
61Single umbilical artery (HP:0001195)2.11425532
62Abnormality of cells of the erythroid lineage (HP:0012130)2.09938417
63Renal Fanconi syndrome (HP:0001994)2.09347926
64Down-sloping shoulders (HP:0200021)2.08890634
65Nephrogenic diabetes insipidus (HP:0009806)2.06798461
66Petechiae (HP:0000967)2.02197768
67Maternal diabetes (HP:0009800)2.02125202
68Recurrent abscess formation (HP:0002722)2.01748884
69Respiratory failure (HP:0002878)2.01568245
70Congenital sensorineural hearing impairment (HP:0008527)2.01405165
71Pancreatic fibrosis (HP:0100732)2.00805190
72Cerebral edema (HP:0002181)1.97992317
73Abnormal number of erythroid precursors (HP:0012131)1.97303827
74Abnormality of the tricuspid valve (HP:0001702)1.96800773
75Congenital primary aphakia (HP:0007707)1.96757484
76Redundant skin (HP:0001582)1.93351847
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92227332
78Progressive neurologic deterioration (HP:0002344)1.91849027
79Double outlet right ventricle (HP:0001719)1.91848859
80Congenital malformation of the right heart (HP:0011723)1.91848859
81Nonimmune hydrops fetalis (HP:0001790)1.86593381
82Abnormality of aromatic amino acid family metabolism (HP:0004338)1.83868072
83Conjunctival telangiectasia (HP:0000524)1.82687933
84Death in infancy (HP:0001522)1.81561353
85Recurrent bacterial skin infections (HP:0005406)1.80516486
86Broad distal phalanx of finger (HP:0009836)1.79033933
87Abnormality of the umbilical cord (HP:0010881)1.78292542
88Gait imbalance (HP:0002141)1.75973994
89Concave nail (HP:0001598)1.74521109
90Dicarboxylic aciduria (HP:0003215)1.74262114
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74262114
92Reticulocytopenia (HP:0001896)1.73519415
93Dysostosis multiplex (HP:0000943)1.73094349
94Medial flaring of the eyebrow (HP:0010747)1.69409672
95Increased serum ferritin (HP:0003281)1.68428386
96Nausea (HP:0002018)1.68167317
97Reduced subcutaneous adipose tissue (HP:0003758)1.67675235
98CNS demyelination (HP:0007305)1.67195697
99Abnormal gallbladder physiology (HP:0012438)1.66948742
100Cholecystitis (HP:0001082)1.66948742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.85632475
2NME24.21700910
3BCKDK3.99565590
4PIM23.45057362
5ERN13.09574742
6STK162.90479142
7ARAF2.86074306
8TESK12.69270526
9MAP2K32.65793559
10MAP3K32.47013913
11SMG12.32801572
12TESK22.17138022
13SCYL22.03541452
14NEK11.94707772
15MAP3K111.87710116
16IRAK31.87103115
17NUAK11.81952539
18EPHA21.55188682
19EPHB21.51112538
20LIMK11.42847600
21TBK11.41639104
22STK41.40458198
23CDK91.40209852
24TRIB31.36939130
25PBK1.34254420
26ABL21.25881618
27BUB11.20906895
28TYK21.17631725
29VRK11.15797458
30DAPK31.11717682
31LRRK21.10801172
32CSNK1G31.07252384
33DAPK11.04698113
34PRKD31.03673115
35PAK41.03530858
36DYRK31.03013000
37AURKA0.99693979
38CCNB10.99128821
39TLK10.96534083
40IRAK20.95924813
41KDR0.95141498
42TAF10.92435842
43NME10.91075200
44IKBKB0.86891829
45SIK10.86097647
46PRKCI0.84069097
47RPS6KB20.80002404
48TRIM280.79044654
49CAMK2G0.76667931
50MAP3K10.73831225
51IKBKE0.70067508
52LMTK20.70012323
53PKN20.68694877
54GRK60.66441582
55DYRK20.65096038
56JAK30.64766163
57ZAK0.62849234
58ADRBK20.62211427
59RPS6KA40.58401092
60CHUK0.57806214
61MAP3K80.56409958
62TAOK20.55134656
63ADRBK10.54509891
64MAP2K60.53630653
65BRAF0.53093333
66PRKG20.53055573
67CSNK1G10.52488872
68CSNK1G20.52085195
69CDK70.51568375
70CDK80.50038210
71FGR0.49834271
72PTK60.49309690
73AURKB0.49131779
74MET0.49000891
75DYRK1B0.47944330
76MAP3K60.47289936
77ILK0.46989139
78RAF10.46338866
79PAK10.45981630
80MAP4K10.43158580
81MAPKAPK20.42999389
82CSNK1A1L0.39859321
83AKT20.38671434
84RPS6KA50.37686477
85CSF1R0.37052482
86PIM10.36711253
87BMPR1B0.35607874
88PRKD10.35198285
89CAMK2D0.34468601
90CAMKK20.33546502
91SGK2230.32515405
92SGK4940.32515405
93CAMK2B0.32269376
94IRAK40.32256826
95IRAK10.30836059
96PRKCD0.30625935
97CSNK1A10.30552150
98BMX0.29895473
99GRK50.29236058
100CSNK2A10.27955897

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.92773178
2Oxidative phosphorylation_Homo sapiens_hsa001903.37131058
3Fatty acid elongation_Homo sapiens_hsa000623.36082063
4Other glycan degradation_Homo sapiens_hsa005113.10817245
5Ribosome_Homo sapiens_hsa030103.10165358
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.88081508
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.78692224
8Proteasome_Homo sapiens_hsa030502.63294295
9Parkinsons disease_Homo sapiens_hsa050122.46176118
10Sulfur metabolism_Homo sapiens_hsa009202.45518851
11Galactose metabolism_Homo sapiens_hsa000522.31481733
12One carbon pool by folate_Homo sapiens_hsa006702.03475418
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94227537
14Folate biosynthesis_Homo sapiens_hsa007901.90869396
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84893654
16Collecting duct acid secretion_Homo sapiens_hsa049661.80488030
17Vibrio cholerae infection_Homo sapiens_hsa051101.77462828
18Huntingtons disease_Homo sapiens_hsa050161.68028078
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66862254
20Alzheimers disease_Homo sapiens_hsa050101.65632235
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.64175934
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61552414
23Glutathione metabolism_Homo sapiens_hsa004801.60600344
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.59934549
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.59058156
26Biosynthesis of amino acids_Homo sapiens_hsa012301.58438929
27Base excision repair_Homo sapiens_hsa034101.53830711
28Lysosome_Homo sapiens_hsa041421.52997870
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47078022
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42930286
31Carbon metabolism_Homo sapiens_hsa012001.40965311
32Peroxisome_Homo sapiens_hsa041461.40846949
33N-Glycan biosynthesis_Homo sapiens_hsa005101.39071479
34Pentose phosphate pathway_Homo sapiens_hsa000301.37105123
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.30496885
36Pyrimidine metabolism_Homo sapiens_hsa002401.29926431
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27752850
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.26265460
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24576221
40Fructose and mannose metabolism_Homo sapiens_hsa000511.24568903
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23936095
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23543687
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19765387
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14142881
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02718946
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02127097
47Steroid biosynthesis_Homo sapiens_hsa001001.00608353
48Metabolic pathways_Homo sapiens_hsa011000.98244540
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94049695
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89616006
51Chemical carcinogenesis_Homo sapiens_hsa052040.89031221
52Fatty acid metabolism_Homo sapiens_hsa012120.88901518
53Starch and sucrose metabolism_Homo sapiens_hsa005000.81761286
54Regulation of autophagy_Homo sapiens_hsa041400.80660735
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.80564363
56Arginine and proline metabolism_Homo sapiens_hsa003300.79949765
57Arginine biosynthesis_Homo sapiens_hsa002200.79879747
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75990224
59Phenylalanine metabolism_Homo sapiens_hsa003600.74758467
60Propanoate metabolism_Homo sapiens_hsa006400.73881753
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72719703
62Tyrosine metabolism_Homo sapiens_hsa003500.71639169
63Arachidonic acid metabolism_Homo sapiens_hsa005900.69692884
64Pyruvate metabolism_Homo sapiens_hsa006200.69310747
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.69214913
66Retinol metabolism_Homo sapiens_hsa008300.66816171
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65550060
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65365278
69Primary immunodeficiency_Homo sapiens_hsa053400.63711894
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59455403
71Fatty acid degradation_Homo sapiens_hsa000710.56303406
72Butanoate metabolism_Homo sapiens_hsa006500.53538865
73Cardiac muscle contraction_Homo sapiens_hsa042600.52014662
74Protein export_Homo sapiens_hsa030600.51156325
75Phagosome_Homo sapiens_hsa041450.46185076
76Homologous recombination_Homo sapiens_hsa034400.45778932
77RNA polymerase_Homo sapiens_hsa030200.44280040
78DNA replication_Homo sapiens_hsa030300.43660623
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42901554
80Purine metabolism_Homo sapiens_hsa002300.42469866
81Notch signaling pathway_Homo sapiens_hsa043300.40400937
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.38966868
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37885226
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36677177
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35538629
86Systemic lupus erythematosus_Homo sapiens_hsa053220.34694573
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34456835
88Nucleotide excision repair_Homo sapiens_hsa034200.34246743
89Synaptic vesicle cycle_Homo sapiens_hsa047210.33813618
90Mismatch repair_Homo sapiens_hsa034300.32981303
91Selenocompound metabolism_Homo sapiens_hsa004500.29287696
92Basal cell carcinoma_Homo sapiens_hsa052170.26512589
93Sphingolipid metabolism_Homo sapiens_hsa006000.25107457
94Hedgehog signaling pathway_Homo sapiens_hsa043400.24417208
95Salmonella infection_Homo sapiens_hsa051320.23722578
96Rheumatoid arthritis_Homo sapiens_hsa053230.23672805
97Alcoholism_Homo sapiens_hsa050340.22833466
98Mineral absorption_Homo sapiens_hsa049780.19272735
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19096902
100Shigellosis_Homo sapiens_hsa051310.16794331

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