TMEM19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.37426383
2L-phenylalanine catabolic process (GO:0006559)7.37426383
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.00012250
4L-phenylalanine metabolic process (GO:0006558)7.00012250
5fucose catabolic process (GO:0019317)6.85878379
6L-fucose metabolic process (GO:0042354)6.85878379
7L-fucose catabolic process (GO:0042355)6.85878379
8aromatic amino acid family catabolic process (GO:0009074)6.52840057
9tryptophan catabolic process (GO:0006569)5.83653180
10indole-containing compound catabolic process (GO:0042436)5.83653180
11indolalkylamine catabolic process (GO:0046218)5.83653180
12eosinophil chemotaxis (GO:0048245)5.83228737
13prenylation (GO:0097354)5.62931565
14protein prenylation (GO:0018342)5.62931565
15bile acid biosynthetic process (GO:0006699)5.60221139
16kynurenine metabolic process (GO:0070189)5.57760718
17glyoxylate metabolic process (GO:0046487)5.56421888
18tryptophan metabolic process (GO:0006568)5.49631675
19cysteine metabolic process (GO:0006534)5.32680651
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29661567
21positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.16722970
22positive regulation of mitotic sister chromatid separation (GO:1901970)5.16722970
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.16722970
24eosinophil migration (GO:0072677)5.15463495
25alpha-linolenic acid metabolic process (GO:0036109)5.10311071
26sulfur amino acid catabolic process (GO:0000098)4.98654613
27urea metabolic process (GO:0019627)4.81664093
28urea cycle (GO:0000050)4.81664093
29aromatic amino acid family metabolic process (GO:0009072)4.70768849
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69217726
31bile acid metabolic process (GO:0008206)4.68805323
32complement activation, alternative pathway (GO:0006957)4.68708048
33high-density lipoprotein particle remodeling (GO:0034375)4.62025385
34regulation of protein activation cascade (GO:2000257)4.59962646
35negative regulation of fibrinolysis (GO:0051918)4.57603297
36protein carboxylation (GO:0018214)4.55971859
37peptidyl-glutamic acid carboxylation (GO:0017187)4.55971859
38lysine metabolic process (GO:0006553)4.50167928
39lysine catabolic process (GO:0006554)4.50167928
40nitrogen cycle metabolic process (GO:0071941)4.49135093
41regulation of fibrinolysis (GO:0051917)4.46175054
42serine family amino acid catabolic process (GO:0009071)4.43950141
43tyrosine metabolic process (GO:0006570)4.43497077
44cellular ketone body metabolic process (GO:0046950)4.36932722
45coenzyme catabolic process (GO:0009109)4.35367484
46regulation of complement activation (GO:0030449)4.33418181
47homocysteine metabolic process (GO:0050667)4.31040377
48alpha-amino acid catabolic process (GO:1901606)4.27049370
49regulation of cholesterol esterification (GO:0010872)4.22617100
50indolalkylamine metabolic process (GO:0006586)4.16823228
51regulation of triglyceride catabolic process (GO:0010896)4.15684011
52reverse cholesterol transport (GO:0043691)4.14682753
53amino-acid betaine metabolic process (GO:0006577)4.14597144
54glutamate metabolic process (GO:0006536)4.08800811
55cellular biogenic amine catabolic process (GO:0042402)4.08455304
56amine catabolic process (GO:0009310)4.08455304
57protein import into peroxisome matrix (GO:0016558)4.05669691
58aldehyde catabolic process (GO:0046185)4.03655078
59cellular modified amino acid catabolic process (GO:0042219)4.02126945
60cellular amino acid catabolic process (GO:0009063)4.01655309
61acetyl-CoA metabolic process (GO:0006084)4.00300584
62plasma lipoprotein particle remodeling (GO:0034369)3.98147758
63protein-lipid complex remodeling (GO:0034368)3.98147758
64macromolecular complex remodeling (GO:0034367)3.98147758
65triglyceride homeostasis (GO:0070328)3.97562156
66acylglycerol homeostasis (GO:0055090)3.97562156
67drug transmembrane transport (GO:0006855)3.96489909
68phospholipid efflux (GO:0033700)3.95725779
69serine family amino acid metabolic process (GO:0009069)3.93860684
70behavioral response to nicotine (GO:0035095)3.93468740
71bile acid and bile salt transport (GO:0015721)3.93089565
72ethanol oxidation (GO:0006069)3.92764818
73cellular glucuronidation (GO:0052695)3.87715563
74fucosylation (GO:0036065)3.87260594
75plasma lipoprotein particle clearance (GO:0034381)3.86885218
76fatty acid elongation (GO:0030497)3.86713698
77negative regulation of sterol transport (GO:0032372)3.84565387
78negative regulation of cholesterol transport (GO:0032375)3.84565387
79short-chain fatty acid metabolic process (GO:0046459)3.83502752
80benzene-containing compound metabolic process (GO:0042537)3.81513721
81cholesterol efflux (GO:0033344)3.80548170
82serine family amino acid biosynthetic process (GO:0009070)3.79975788
83ketone body metabolic process (GO:1902224)3.79623220
84autophagic vacuole fusion (GO:0000046)3.76251600
85urate metabolic process (GO:0046415)3.74389890
86imidazole-containing compound metabolic process (GO:0052803)3.74059116
87cofactor catabolic process (GO:0051187)3.71714598
88very long-chain fatty acid metabolic process (GO:0000038)3.70591331
89drug catabolic process (GO:0042737)3.68964360
90aspartate family amino acid catabolic process (GO:0009068)3.65690669
91regulation of mononuclear cell migration (GO:0071675)3.64713891
92uronic acid metabolic process (GO:0006063)3.60621595
93glucuronate metabolic process (GO:0019585)3.60621595
94dicarboxylic acid biosynthetic process (GO:0043650)3.59563082
95phosphatidylinositol acyl-chain remodeling (GO:0036149)3.59542439
96glycine metabolic process (GO:0006544)3.56685253
97heme transport (GO:0015886)3.55395050
98organic acid catabolic process (GO:0016054)3.55180634
99carboxylic acid catabolic process (GO:0046395)3.55180634
100arginine metabolic process (GO:0006525)3.54495879
101organelle membrane fusion (GO:0090174)3.53365439
102low-density lipoprotein particle remodeling (GO:0034374)3.52580202
103negative regulation of T cell receptor signaling pathway (GO:0050860)3.51794127
104fibrinolysis (GO:0042730)3.51770324
105sulfation (GO:0051923)3.48891883
106regulation of bile acid biosynthetic process (GO:0070857)3.48228745
107oxidative demethylation (GO:0070989)3.44289805
108complement activation, classical pathway (GO:0006958)3.41663216
109cholesterol homeostasis (GO:0042632)3.40688736
110regulation of cholesterol homeostasis (GO:2000188)3.40057415
111opsonization (GO:0008228)3.37625955
112sterol homeostasis (GO:0055092)3.37176142
113plasma lipoprotein particle assembly (GO:0034377)3.35820917
114fucose metabolic process (GO:0006004)3.34194487
115positive regulation of triglyceride lipase activity (GO:0061365)3.33829468
116positive regulation of lipoprotein lipase activity (GO:0051006)3.33829468
117fatty acid beta-oxidation (GO:0006635)3.33639264
118complement activation (GO:0006956)3.32714938
119exogenous drug catabolic process (GO:0042738)3.32270335
120monocarboxylic acid catabolic process (GO:0072329)3.32091918
121cytolysis (GO:0019835)3.31797578
122preassembly of GPI anchor in ER membrane (GO:0016254)3.31077507
123protein targeting to vacuole (GO:0006623)3.30162376
124protein targeting to lysosome (GO:0006622)3.30162376
125establishment of protein localization to vacuole (GO:0072666)3.30162376
126negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.19014477
127flavonoid metabolic process (GO:0009812)3.15898152
128gonadal mesoderm development (GO:0007506)3.13756078
129negative regulation of Ras GTPase activity (GO:0034261)3.07434461
130regulation of glucokinase activity (GO:0033131)3.03184759
131regulation of hexokinase activity (GO:1903299)3.03184759
132adaptation of signaling pathway (GO:0023058)3.02789439
133negative regulation of mast cell activation (GO:0033004)3.02497751
134water-soluble vitamin biosynthetic process (GO:0042364)3.01042519
135phosphatidylserine acyl-chain remodeling (GO:0036150)2.98499965
136organ growth (GO:0035265)2.98044490
137regulation of sister chromatid cohesion (GO:0007063)2.91079698
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90844477
139response to pheromone (GO:0019236)2.87824952
140neurotransmitter metabolic process (GO:0042133)2.85911181
141methionine biosynthetic process (GO:0009086)2.78629260
142cellular response to ATP (GO:0071318)2.75885013
143positive regulation of calcium ion import (GO:0090280)2.73464273
144regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.72827685
145cellular response to exogenous dsRNA (GO:0071360)2.72581101
146regulation of beta-amyloid formation (GO:1902003)2.71372082
147vesicle fusion (GO:0006906)2.70937144
148negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.70217725
149proline transport (GO:0015824)2.68341346
150serotonin metabolic process (GO:0042428)2.66124728
151regulation of T cell receptor signaling pathway (GO:0050856)2.62937686
152cytidine metabolic process (GO:0046087)2.60274615
153cytidine catabolic process (GO:0006216)2.60274615
154cytidine deamination (GO:0009972)2.60274615
155neurotransmitter biosynthetic process (GO:0042136)2.60100276
156acrosome assembly (GO:0001675)2.56156232
157regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.53710996
158primary amino compound metabolic process (GO:1901160)2.53673078
159protein targeting to peroxisome (GO:0006625)2.53436215
160establishment of protein localization to peroxisome (GO:0072663)2.53436215
161protein localization to peroxisome (GO:0072662)2.53436215
162branch elongation of an epithelium (GO:0060602)2.52309985
163L-methionine salvage (GO:0071267)2.50855163
164L-methionine biosynthetic process (GO:0071265)2.50855163
165amino acid salvage (GO:0043102)2.50855163
166indole-containing compound metabolic process (GO:0042430)2.49409869
167positive regulation of fatty acid transport (GO:2000193)2.47824196
168regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.47131876
169detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.45292168
170positive regulation of fatty acid oxidation (GO:0046321)2.45154019
171positive regulation of fatty acid beta-oxidation (GO:0032000)2.43062115
172regulation of guanylate cyclase activity (GO:0031282)2.41525218
173purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.41497785
1743-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.41497785
175gamma-aminobutyric acid transport (GO:0015812)2.41049335
176GPI anchor metabolic process (GO:0006505)2.39848844
177parturition (GO:0007567)2.39756215
178DNA demethylation (GO:0080111)2.39414722
179detection of light stimulus involved in visual perception (GO:0050908)2.37743258
180detection of light stimulus involved in sensory perception (GO:0050962)2.37743258
181phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.36818188
182intracellular pH reduction (GO:0051452)2.36516343
183sodium-independent organic anion transport (GO:0043252)2.35676826
184pyrimidine ribonucleoside catabolic process (GO:0046133)2.35398062
185angiotensin maturation (GO:0002003)2.35110379
186sphingoid metabolic process (GO:0046519)2.34587888
187S-adenosylmethionine metabolic process (GO:0046500)2.33855137
188positive regulation of chromosome segregation (GO:0051984)2.33152878
189detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.32119253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.27110316
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.16234853
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.95117174
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.72819176
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.61296839
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.19181380
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.06221852
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.46599708
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.40412209
10VDR_22108803_ChIP-Seq_LS180_Human3.15023992
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12850165
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.99703381
13GBX2_23144817_ChIP-Seq_PC3_Human2.96969707
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.94371513
15ZNF274_21170338_ChIP-Seq_K562_Hela2.76421880
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44289607
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.40217722
18EZH2_22144423_ChIP-Seq_EOC_Human2.31191098
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17553657
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13558773
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12061203
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10982555
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2752614
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89344806
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85672182
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.83826177
27NR3C1_21868756_ChIP-Seq_MCF10A_Human1.79951353
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78251995
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75177122
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73360028
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71691877
32P300_19829295_ChIP-Seq_ESCs_Human1.71265185
33IGF1R_20145208_ChIP-Seq_DFB_Human1.70757130
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69217305
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68274964
36FUS_26573619_Chip-Seq_HEK293_Human1.68067048
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67572722
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.59886867
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57914940
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.57810505
41ER_23166858_ChIP-Seq_MCF-7_Human1.56956015
42STAT3_23295773_ChIP-Seq_U87_Human1.56938202
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.52769830
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52720407
45SMAD4_21799915_ChIP-Seq_A2780_Human1.51077074
46HTT_18923047_ChIP-ChIP_STHdh_Human1.50238751
47CLOCK_20551151_ChIP-Seq_293T_Human1.49399028
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.43684035
49EWS_26573619_Chip-Seq_HEK293_Human1.41730755
50AR_21572438_ChIP-Seq_LNCaP_Human1.40458750
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40330875
52TCF4_23295773_ChIP-Seq_U87_Human1.38813743
53* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37856822
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36261663
55P53_22387025_ChIP-Seq_ESCs_Mouse1.35748043
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35367308
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.34866870
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34024017
59* CRX_20693478_ChIP-Seq_RETINA_Mouse1.33671666
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31978212
61CBP_20019798_ChIP-Seq_JUKART_Human1.31978212
62AR_25329375_ChIP-Seq_VCAP_Human1.30231366
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29736606
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29245090
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29245090
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.28064428
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.27999301
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25981204
69* HNF4A_19822575_ChIP-Seq_HepG2_Human1.25636277
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.24732192
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23998251
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23998251
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23745183
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22746766
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21416984
76* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21194100
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.20109519
78TCF4_22108803_ChIP-Seq_LS180_Human1.19650659
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.19248271
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18503441
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18133058
82RXR_22108803_ChIP-Seq_LS180_Human1.17651860
83SOX2_19829295_ChIP-Seq_ESCs_Human1.17617857
84NANOG_19829295_ChIP-Seq_ESCs_Human1.17617857
85TP53_16413492_ChIP-PET_HCT116_Human1.16440657
86* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15717572
87GATA1_22025678_ChIP-Seq_K562_Human1.13735974
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.13234408
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12588853
90KDM2B_26808549_Chip-Seq_REH_Human1.12148605
91IRF1_19129219_ChIP-ChIP_H3396_Human1.12136246
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11704390
93* FLI1_21867929_ChIP-Seq_TH2_Mouse1.11222679
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11016082
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.10619924
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10459192
97TP53_22573176_ChIP-Seq_HFKS_Human1.08447775
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.08156163
99P300_18555785_Chip-Seq_ESCs_Mouse1.07204778
100* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06588413
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05077482
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04915647
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04564123
104OCT4_18555785_Chip-Seq_ESCs_Mouse1.02975411
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02862582
106CJUN_26792858_Chip-Seq_BT549_Human1.02304253
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01368373
108CTCF_18555785_Chip-Seq_ESCs_Mouse1.01164554
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00321348
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00078145
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99193648
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99160532
113AHR_22903824_ChIP-Seq_MCF-7_Human0.98339626
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.97210326
115GATA4_25053715_ChIP-Seq_YYC3_Human0.90600282
116EGR1_19032775_ChIP-ChIP_M12_Human0.90026141
117* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89070866
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.85662006
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85473317
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84144813
121TAF15_26573619_Chip-Seq_HEK293_Human0.83623280
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.82794371
123SOX2_20726797_ChIP-Seq_SW620_Human0.82295755
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82265267
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80677483
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78149242
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77216052
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76137699
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.74919349
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73918456
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70098564
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69916389
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.69294493
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68416888
135ESR1_21235772_ChIP-Seq_MCF-7_Human0.68176787
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.67124426
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.67054390
138RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66982893
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.64939307
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.64491116
141CBP_21632823_ChIP-Seq_H3396_Human0.63312602
142MYC_19915707_ChIP-ChIP_AK7_Human0.62885055
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62501876
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.61606739
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60174470
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57804013
147CEBPB_22108803_ChIP-Seq_LS180_Human0.56113243
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56096735
149* TP63_23658742_ChIP-Seq_EP156T_Human0.55046626
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.55012841
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.54047488
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52786200
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52487718
154SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.52222533
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.52216816
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.51564128
157NCOR_22424771_ChIP-Seq_293T_Human0.51324422
158GATA2_19941826_ChIP-Seq_K562_Human0.51279283
159FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51109142
160KAP1_22055183_ChIP-Seq_ESCs_Mouse0.50979916
161OCT4_20526341_ChIP-Seq_ESCs_Human0.50596238
162P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.50582306
163CDX2_22108803_ChIP-Seq_LS180_Human0.50004703
164GATA1_19941826_ChIP-Seq_K562_Human0.49981623
165PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49964664
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.49394892
167LXR_22292898_ChIP-Seq_THP-1_Human0.49299349
168ESET_19884257_ChIP-Seq_ESCs_Mouse0.49079532
169RARB_24833708_ChIP-Seq_LIVER_Mouse0.48689062
170AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.48566294
171BCAT_22108803_ChIP-Seq_LS180_Human0.48492458
172AR_20517297_ChIP-Seq_VCAP_Human0.48301521
173* IRF8_27001747_Chip-Seq_BMDM_Mouse0.48282147
174PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47404859
175IRF8_21731497_ChIP-ChIP_J774_Mouse0.47124737
176TAF2_19829295_ChIP-Seq_ESCs_Human0.46865783
177RARA_24833708_ChIP-Seq_LIVER_Mouse0.46597230
178STAT1_17558387_ChIP-Seq_HELA_Human0.46452212
179CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.45636515
180* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.45560699
181GATA2_21666600_ChIP-Seq_HMVEC_Human0.45209773
182* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.44669921
183TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.43780340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.51156820
2MP0005360_urolithiasis7.50879799
3MP0005085_abnormal_gallbladder_physiolo5.71512844
4MP0005365_abnormal_bile_salt5.37541179
5MP0008875_abnormal_xenobiotic_pharmacok4.63127371
6MP0003806_abnormal_nucleotide_metabolis4.27095508
7MP0000566_synostosis3.83670188
8MP0003646_muscle_fatigue3.77062080
9MP0003252_abnormal_bile_duct3.55412017
10MP0000569_abnormal_digit_pigmentation3.42167687
11MP0009840_abnormal_foam_cell3.34647612
12MP0003195_calcinosis3.25900639
13MP0003303_peritoneal_inflammation3.25171281
14MP0010329_abnormal_lipoprotein_level3.04780280
15MP0005332_abnormal_amino_acid3.04764803
16MP0004145_abnormal_muscle_electrophysio2.90248381
17MP0002102_abnormal_ear_morphology2.62100278
18MP0000383_abnormal_hair_follicle2.49244733
19MP0001666_abnormal_nutrient_absorption2.46317273
20MP0005083_abnormal_biliary_tract2.43800184
21MP0002837_dystrophic_cardiac_calcinosis2.41182827
22MP0003191_abnormal_cellular_cholesterol2.33687026
23MP0004019_abnormal_vitamin_homeostasis2.32184322
24MP0002138_abnormal_hepatobiliary_system2.29586780
25MP0001664_abnormal_digestion2.27930281
26MP0000427_abnormal_hair_cycle2.04583344
27MP0010678_abnormal_skin_adnexa2.02115849
28MP0002118_abnormal_lipid_homeostasis2.01523153
29MP0000609_abnormal_liver_physiology1.90406245
30MP0002254_reproductive_system_inflammat1.75622941
31MP0008872_abnormal_physiological_respon1.71406470
32MP0005584_abnormal_enzyme/coenzyme_acti1.69797718
33MP0003868_abnormal_feces_composition1.67991416
34MP0000604_amyloidosis1.65846616
35MP0009643_abnormal_urine_homeostasis1.61938214
36MP0005319_abnormal_enzyme/_coenzyme1.61533761
37MP0001663_abnormal_digestive_system1.56996796
38MP0004215_abnormal_myocardial_fiber1.56681160
39MP0005451_abnormal_body_composition1.56087201
40MP0001919_abnormal_reproductive_system1.54821674
41MP0003329_amyloid_beta_deposits1.52473773
42MP0001764_abnormal_homeostasis1.48753004
43MP0005551_abnormal_eye_electrophysiolog1.45707528
44MP0004484_altered_response_of1.39542603
45MP0003183_abnormal_peptide_metabolism1.39028630
46MP0003690_abnormal_glial_cell1.38395156
47MP0005253_abnormal_eye_physiology1.35346353
48MP0005645_abnormal_hypothalamus_physiol1.34958164
49MP0000372_irregular_coat_pigmentation1.32548560
50MP0002876_abnormal_thyroid_physiology1.32434084
51MP0003186_abnormal_redox_activity1.32264205
52MP0009046_muscle_twitch1.30617047
53MP0001986_abnormal_taste_sensitivity1.28633665
54MP0001501_abnormal_sleep_pattern1.21031069
55MP0005636_abnormal_mineral_homeostasis1.20359083
56MP0005058_abnormal_lysosome_morphology1.19464406
57MP0004084_abnormal_cardiac_muscle1.18378085
58MP0005646_abnormal_pituitary_gland1.18242543
59MP0005389_reproductive_system_phenotype1.17446072
60MP0003045_fibrosis1.17229850
61MP0009780_abnormal_chondrocyte_physiolo1.16189277
62MP0003011_delayed_dark_adaptation1.15699526
63MP0003656_abnormal_erythrocyte_physiolo1.13710491
64MP0002909_abnormal_adrenal_gland1.12065392
65MP0005381_digestive/alimentary_phenotyp1.10935780
66MP0000920_abnormal_myelination1.08885233
67MP0002095_abnormal_skin_pigmentation1.08269921
68MP0009745_abnormal_behavioral_response1.07163246
69MP0004043_abnormal_pH_regulation1.05723811
70MP0005620_abnormal_muscle_contractility1.04944198
71MP0002272_abnormal_nervous_system1.04351562
72MP0005647_abnormal_sex_gland1.02758847
73MP0002751_abnormal_autonomic_nervous1.02739694
74MP0002332_abnormal_exercise_endurance1.02432146
75MP0005671_abnormal_response_to1.02020569
76MP0000467_abnormal_esophagus_morphology1.00758149
77MP0010386_abnormal_urinary_bladder0.99227154
78MP0009764_decreased_sensitivity_to0.97895995
79MP0009697_abnormal_copulation0.96731439
80MP0000598_abnormal_liver_morphology0.94913851
81MP0001440_abnormal_grooming_behavior0.94811073
82MP0005174_abnormal_tail_pigmentation0.94139808
83MP0004142_abnormal_muscle_tone0.94076028
84MP0004036_abnormal_muscle_relaxation0.92940070
85MP0001968_abnormal_touch/_nociception0.92628285
86MP0002638_abnormal_pupillary_reflex0.92248293
87MP0004134_abnormal_chest_morphology0.91285880
88MP0002735_abnormal_chemical_nociception0.91047851
89MP0008775_abnormal_heart_ventricle0.91021579
90MP0008469_abnormal_protein_level0.89239849
91MP0004270_analgesia0.88554892
92MP0002733_abnormal_thermal_nociception0.88420695
93MP0006082_CNS_inflammation0.88263313
94MP0001756_abnormal_urination0.88117020
95MP0002693_abnormal_pancreas_physiology0.86330405
96MP0001661_extended_life_span0.84921713
97MP0009763_increased_sensitivity_to0.84890710
98MP0002796_impaired_skin_barrier0.83618573
99MP0001790_abnormal_immune_system0.82641302
100MP0005387_immune_system_phenotype0.82641302
101MP0000015_abnormal_ear_pigmentation0.81117207
102MP0009642_abnormal_blood_homeostasis0.80979252
103MP0001485_abnormal_pinna_reflex0.79294706
104MP0002234_abnormal_pharynx_morphology0.79217246
105MP0004924_abnormal_behavior0.78724479
106MP0005386_behavior/neurological_phenoty0.78724479
107MP0006276_abnormal_autonomic_nervous0.78616190
108MP0009765_abnormal_xenobiotic_induced0.77029240
109MP0005535_abnormal_body_temperature0.76698757
110MP0001800_abnormal_humoral_immune0.76411721
111MP0002734_abnormal_mechanical_nocicepti0.76370376
112MP0002136_abnormal_kidney_physiology0.75389577
113MP0002064_seizures0.75332027
114MP0005408_hypopigmentation0.75040030
115MP0006036_abnormal_mitochondrial_physio0.74361047
116MP0003879_abnormal_hair_cell0.71230462
117MP0000749_muscle_degeneration0.70691169
118MP0005376_homeostasis/metabolism_phenot0.70677534
119MP0001835_abnormal_antigen_presentation0.70215148
120MP0000631_abnormal_neuroendocrine_gland0.68942749
121MP0002009_preneoplasia0.68702786
122MP0004381_abnormal_hair_follicle0.67165188
123MP0000579_abnormal_nail_morphology0.64782619
124MP0001765_abnormal_ion_homeostasis0.64750681
125MP0005084_abnormal_gallbladder_morpholo0.64097643
126MP0003075_altered_response_to0.63965304
127MP0002971_abnormal_brown_adipose0.63649814
128MP0002078_abnormal_glucose_homeostasis0.63606204
129MP0003705_abnormal_hypodermis_morpholog0.62478812
130MP0005220_abnormal_exocrine_pancreas0.58131456
131MP0009384_cardiac_valve_regurgitation0.54739813
132MP0002822_catalepsy0.54481509
133MP0010234_abnormal_vibrissa_follicle0.54440501
134MP0003638_abnormal_response/metabolism_0.54148843
135MP0005334_abnormal_fat_pad0.53726325
136MP0005395_other_phenotype0.52331259
137MP0008874_decreased_physiological_sensi0.51767837
138MP0005266_abnormal_metabolism0.49459138
139MP0004885_abnormal_endolymph0.48245137
140MP0000639_abnormal_adrenal_gland0.47865301
141MP0000230_abnormal_systemic_arterial0.47857441
142MP0002295_abnormal_pulmonary_circulatio0.47379975
143MP0006035_abnormal_mitochondrial_morpho0.47357504
144MP0004130_abnormal_muscle_cell0.46469087
145MP0003724_increased_susceptibility_to0.45646973
146MP0000538_abnormal_urinary_bladder0.45042081
147MP0004147_increased_porphyrin_level0.44684009
148MP0003718_maternal_effect0.43410706
149MP0003453_abnormal_keratinocyte_physiol0.42937585
150MP0003632_abnormal_nervous_system0.41905360
151MP0002168_other_aberrant_phenotype0.41599047
152MP0005166_decreased_susceptibility_to0.41366899
153MP0005448_abnormal_energy_balance0.41093756
154MP0008873_increased_physiological_sensi0.40491120
155MP0001243_abnormal_dermal_layer0.40354683
156MP0002090_abnormal_vision0.38914041
157MP0000685_abnormal_immune_system0.38775241
158MP0004947_skin_inflammation0.38420976
159MP0003436_decreased_susceptibility_to0.38406926
160MP0002060_abnormal_skin_morphology0.38343910
161MP0003633_abnormal_nervous_system0.37962302
162MP0010368_abnormal_lymphatic_system0.37156052
163MP0002928_abnormal_bile_duct0.35774895
164MP0005464_abnormal_platelet_physiology0.34722296
165MP0003172_abnormal_lysosome_physiology0.34619969
166MP0001845_abnormal_inflammatory_respons0.34108693
167MP0000647_abnormal_sebaceous_gland0.33538790
168MP0005670_abnormal_white_adipose0.33354141

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.80999860
2Intrahepatic cholestasis (HP:0001406)6.64185758
3Deep venous thrombosis (HP:0002625)6.09030230
4Xanthomatosis (HP:0000991)5.83876727
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.57162134
6Prolonged partial thromboplastin time (HP:0003645)5.28644026
7Hypobetalipoproteinemia (HP:0003563)5.14918707
8Hyperlipoproteinemia (HP:0010980)4.82047607
9Complement deficiency (HP:0004431)4.81803375
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32100285
11Epidermoid cyst (HP:0200040)4.26392233
12Large for gestational age (HP:0001520)4.21081381
13Hyperammonemia (HP:0001987)4.12446793
14Ketosis (HP:0001946)4.02796269
15Abnormality of aspartate family amino acid metabolism (HP:0010899)4.02144780
16Hyperglycinemia (HP:0002154)4.00172907
17Abnormality of glycine metabolism (HP:0010895)3.96634945
18Abnormality of serine family amino acid metabolism (HP:0010894)3.96634945
19Hyperglycinuria (HP:0003108)3.90921527
20Fat malabsorption (HP:0002630)3.90735713
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.90450977
22Hypolipoproteinemia (HP:0010981)3.79177264
23Joint hemorrhage (HP:0005261)3.77569859
24Abnormality of methionine metabolism (HP:0010901)3.70799869
25Abnormality of the common coagulation pathway (HP:0010990)3.65658000
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.56066059
27Abnormality of complement system (HP:0005339)3.48246293
28Conjugated hyperbilirubinemia (HP:0002908)3.44351347
29Hyperventilation (HP:0002883)3.37852838
30Abnormality of fatty-acid metabolism (HP:0004359)3.35603887
31Broad-based gait (HP:0002136)3.34543784
32Decreased circulating renin level (HP:0003351)3.27476017
33Hypoalphalipoproteinemia (HP:0003233)3.24916137
34Abnormality of midbrain morphology (HP:0002418)3.24699389
35Molar tooth sign on MRI (HP:0002419)3.24699389
36Pancreatic cysts (HP:0001737)3.23712858
37Hypoglycemic coma (HP:0001325)3.13379689
38Abnormality of the intrinsic pathway (HP:0010989)3.10865257
39Steatorrhea (HP:0002570)3.10064846
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.06819451
41Progressive inability to walk (HP:0002505)3.05112112
42Ketoacidosis (HP:0001993)3.04374700
43True hermaphroditism (HP:0010459)3.01563653
44Renal cortical cysts (HP:0000803)2.97875733
45Gout (HP:0001997)2.97441777
46Hypercholesterolemia (HP:0003124)2.97061573
47Abnormality of the renal collecting system (HP:0004742)2.93149656
48Abnormality of purine metabolism (HP:0004352)2.86533832
49Abolished electroretinogram (ERG) (HP:0000550)2.84133169
50Delayed CNS myelination (HP:0002188)2.84126745
51Duplicated collecting system (HP:0000081)2.84007321
52Hyperbilirubinemia (HP:0002904)2.81138139
53Abnormality of nucleobase metabolism (HP:0010932)2.81094084
54Abnormality of the renal cortex (HP:0011035)2.80554458
55Neurofibrillary tangles (HP:0002185)2.77729705
56Pancreatic fibrosis (HP:0100732)2.73936280
57Severe muscular hypotonia (HP:0006829)2.73699300
58Myocardial infarction (HP:0001658)2.70283922
59Abnormality of pyrimidine metabolism (HP:0004353)2.70214587
60Systemic lupus erythematosus (HP:0002725)2.69612421
61Inability to walk (HP:0002540)2.64872197
62Metabolic acidosis (HP:0001942)2.64107629
63Vascular calcification (HP:0004934)2.62884292
64Abnormality of serum amino acid levels (HP:0003112)2.62368718
65Calf muscle hypertrophy (HP:0008981)2.60584979
66Type II lissencephaly (HP:0007260)2.52533854
67Abnormal gallbladder morphology (HP:0012437)2.50554475
68Lethargy (HP:0001254)2.50552068
69Congenital stationary night blindness (HP:0007642)2.49289441
70Hepatocellular carcinoma (HP:0001402)2.47617460
71Alkalosis (HP:0001948)2.47429377
72Furrowed tongue (HP:0000221)2.47011784
73Metabolic alkalosis (HP:0200114)2.46722569
74Spontaneous abortion (HP:0005268)2.46444655
75Agitation (HP:0000713)2.46249385
76Muscle hypertrophy of the lower extremities (HP:0008968)2.46172785
77Congenital sensorineural hearing impairment (HP:0008527)2.45788002
78Hypoplasia of the fovea (HP:0007750)2.44823038
79Aplasia/Hypoplasia of the fovea (HP:0008060)2.44823038
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44413316
81Dicarboxylic aciduria (HP:0003215)2.44413316
82Irritability (HP:0000737)2.43841231
83Abnormal gallbladder physiology (HP:0012438)2.42506728
84Cholecystitis (HP:0001082)2.42506728
85Skin nodule (HP:0200036)2.40427635
86Mitral stenosis (HP:0001718)2.35977039
87Amyloidosis (HP:0011034)2.35630529
88Cholelithiasis (HP:0001081)2.35151146
89Nemaline bodies (HP:0003798)2.35079637
90Cardiovascular calcification (HP:0011915)2.34975298
91Muscle fiber inclusion bodies (HP:0100299)2.34083500
92Recurrent gram-negative bacterial infections (HP:0005420)2.32713946
93Fair hair (HP:0002286)2.32549201
94Cerebral edema (HP:0002181)2.30723492
95Rickets (HP:0002748)2.30027760
96Widely spaced teeth (HP:0000687)2.29701191
97Hypophosphatemic rickets (HP:0004912)2.29447457
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29152764
99Abnormality of alanine metabolism (HP:0010916)2.29152764
100Hyperalaninemia (HP:0003348)2.29152764
101Gaze-evoked nystagmus (HP:0000640)2.27684864
102Generalized aminoaciduria (HP:0002909)2.27562851
103Hypochromic microcytic anemia (HP:0004840)2.27459680
104Congenital, generalized hypertrichosis (HP:0004540)2.26882273
105Conjunctival hamartoma (HP:0100780)2.26427192
106Hydroxyprolinuria (HP:0003080)2.26062824
107Abnormality of proline metabolism (HP:0010907)2.26062824
108Palmoplantar hyperkeratosis (HP:0000972)2.24291215
109Sensorimotor neuropathy (HP:0007141)2.23630726
110Chronic hepatic failure (HP:0100626)2.23571876
111Abnormality of vitamin B metabolism (HP:0004340)2.23381249
112Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.22528094
113Abnormality of the vitamin B12 metabolism (HP:0004341)2.22348935
114Malnutrition (HP:0004395)2.22217280
115Nephronophthisis (HP:0000090)2.20035669
116Vomiting (HP:0002013)2.18961996
117Spastic paraparesis (HP:0002313)2.18781916
118Palmar hyperkeratosis (HP:0010765)2.17989346
119Abnormality of glycolipid metabolism (HP:0010969)2.17338403
120Abnormality of liposaccharide metabolism (HP:0010968)2.17338403
121Abnormality of glycosphingolipid metabolism (HP:0004343)2.17338403
122Cerebral inclusion bodies (HP:0100314)2.16420748
123Abnormal enzyme/coenzyme activity (HP:0012379)2.15218971
124Abnormality of the fovea (HP:0000493)2.14542473
125Opisthotonus (HP:0002179)2.13285895
126Hypoplastic pelvis (HP:0008839)2.12892045
127Methylmalonic acidemia (HP:0002912)2.12231214
128Chorioretinal atrophy (HP:0000533)2.12180967
129Hypokalemia (HP:0002900)2.11665872
130Methylmalonic aciduria (HP:0012120)2.08653222
131Attenuation of retinal blood vessels (HP:0007843)2.06476435
132Brushfield spots (HP:0001088)2.06424272
133Plantar hyperkeratosis (HP:0007556)2.06164823
134Acanthocytosis (HP:0001927)2.04675463
135Increased purine levels (HP:0004368)2.04498012
136Hyperuricemia (HP:0002149)2.04498012
137Neonatal onset (HP:0003623)2.04335218
138Glomerulonephritis (HP:0000099)2.04235662
139Proximal tubulopathy (HP:0000114)2.03694250
140Tubular atrophy (HP:0000092)2.03422563
141Abnormality of the gallbladder (HP:0005264)2.03324127
142Hypoplastic iliac wings (HP:0002866)2.02141332
143Glycosuria (HP:0003076)2.01740754
144Abnormality of urine glucose concentration (HP:0011016)2.01740754
145Lissencephaly (HP:0001339)2.00677615
146Generalized hypopigmentation of hair (HP:0011358)2.00294301
147Spastic diplegia (HP:0001264)2.00088899
148Absent speech (HP:0001344)1.99735711
149Hypoglycemic seizures (HP:0002173)1.99486899
150Myoglobinuria (HP:0002913)1.98898057
151Protuberant abdomen (HP:0001538)1.98002429
152Abnormality of the renal medulla (HP:0100957)1.97587743
153Long foot (HP:0001833)1.96842549
154Elevated alkaline phosphatase (HP:0003155)1.96383089
155Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95849349
156Vacuolated lymphocytes (HP:0001922)1.94034107
157Pancreatitis (HP:0001733)1.93909563
158Abnormality of renin-angiotensin system (HP:0000847)1.93458029
159Abnormality of alkaline phosphatase activity (HP:0004379)1.92660375
160Confusion (HP:0001289)1.91911153
161Enlarged kidneys (HP:0000105)1.91427642
162Abnormality of potassium homeostasis (HP:0011042)1.90924180
163Cerebral hemorrhage (HP:0001342)1.90867085
164Dry hair (HP:0011359)1.89593706
165Pendular nystagmus (HP:0012043)1.88613336
166Polymicrogyria (HP:0002126)1.88302546
167Hypoalbuminemia (HP:0003073)1.87342543
168Abnormal albumin level (HP:0012116)1.87342543
169Long nose (HP:0003189)1.87067022
170Late onset (HP:0003584)1.86199914
171Hypoplastic nipples (HP:0002557)1.85531438
172Hemiparesis (HP:0001269)1.85517794
173Gingival bleeding (HP:0000225)1.85223211
174Paraparesis (HP:0002385)1.84579224
175Absent/shortened dynein arms (HP:0200106)1.84337233
176Dynein arm defect of respiratory motile cilia (HP:0012255)1.84337233
177Medial flaring of the eyebrow (HP:0010747)1.83226852
178Axonal loss (HP:0003447)1.83225403
179Adactyly (HP:0009776)1.82695706
180Hypokalemic alkalosis (HP:0001949)1.80603893
181Hamartoma of the eye (HP:0010568)1.79509495
182Clubbing of toes (HP:0100760)1.79487827
183Abnormality of B cell number (HP:0010975)1.75257604
184Aplasia/Hypoplasia of the tibia (HP:0005772)1.74581437
185Abnormality of vitamin metabolism (HP:0100508)1.72808962
186Goiter (HP:0000853)1.72620184
187Keratoconus (HP:0000563)1.71461734
188Increased corneal curvature (HP:0100692)1.71461734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.97632366
2BCKDK5.08955527
3TAOK14.43387602
4MKNK13.72110148
5FGFR43.59315254
6ERN13.34175843
7OXSR13.32942616
8ACVR1B3.28465297
9EPHB13.21635346
10TAOK33.20790899
11ADRBK23.15758015
12STK393.06612280
13ERBB42.93847174
14WNK42.60297165
15OBSCN2.30782516
16SIK12.30642608
17INSRR2.22063480
18MAP3K32.18375383
19TLK12.08953813
20TAOK22.08804147
21MAP3K112.06430462
22MAP3K141.93083362
23PHKG11.83760005
24PHKG21.83760005
25WNK31.80597726
26MET1.74484931
27PKN11.65083469
28TYK21.59607918
29MAP2K31.54024055
30GRK11.48961804
31MAP2K41.47316841
32FGFR21.40662300
33MST41.36849207
34MST1R1.36363616
35BCR1.33091768
36CASK1.31865647
37MAPK111.31699055
38PIK3CG1.30620274
39MAP3K41.30525953
40MAP3K131.27699239
41ABL21.26345053
42JAK31.22046592
43PBK1.21787842
44MAPK151.21697206
45TBK11.16477277
46SGK2231.15403086
47SGK4941.15403086
48TRPM71.11290669
49GRK61.09959949
50PTK61.07191878
51SCYL21.05758234
52ERBB31.04979843
53EIF2AK31.00911051
54EPHA31.00848438
55PINK10.96368389
56CAMK2G0.94646101
57NTRK10.94112654
58ICK0.93477567
59NUAK10.93041066
60TESK20.92990744
61MAPK130.92495356
62JAK20.92019587
63ADRBK10.90963261
64MAP3K70.90086691
65BMPR1B0.89228290
66JAK10.88872745
67PRKCQ0.88449071
68EPHA40.88101109
69MARK10.86480531
70ZAK0.86284944
71PTK20.83110924
72PRKCZ0.82701130
73NEK90.82031277
74PRKAA20.80922177
75DYRK1B0.80583630
76DAPK20.80515884
77GSK3A0.79560443
78ITK0.77329643
79LATS10.76987556
80FRK0.75920469
81FLT30.75845067
82CSF1R0.74790056
83PAK30.74779158
84DYRK1A0.74430765
85CAMKK20.74376084
86MUSK0.73752882
87MAPKAPK30.73550328
88IRAK10.72997742
89LIMK10.71933181
90PDPK10.70950927
91NEK10.70947382
92IKBKE0.70227240
93FGR0.69429009
94IRAK30.68531149
95MAP2K70.68357784
96CSK0.67616537
97CCNB10.66721280
98CSNK1G30.66228425
99GRK70.65475676
100BLK0.65439898
101ARAF0.65437606
102EIF2AK10.65189746
103MAPK40.64531317
104STK38L0.64030217
105CSNK1G10.63645310
106WNK10.60813072
107SYK0.58306310
108NEK20.57737849
109CSNK1G20.56762322
110PRKACG0.56250816
111IRAK20.55958326
112PIK3CA0.51395464
113MAPK120.51325381
114CSNK1A1L0.48454619
115CAMK2B0.46659688
116MAP3K50.46404671
117MAP2K10.46320993
118KSR20.46131625
119ERBB20.45565400
120MAP2K60.45518621
121TGFBR10.44019038
122MAPK70.43911266
123KIT0.43496917
124FER0.42811111
125MAP2K20.42794730
126MAPKAPK50.41382749
127CSNK1A10.41355926
128EGFR0.41150303
129STK110.40233138
130TXK0.39909988
131MAP4K20.39248176
132CHEK20.38993566
133PRKCH0.36854042
134CAMK2A0.35386097
135STK30.34906811
136CDK30.34701572
137PRKACA0.34113897
138PRKD10.33125914
139PRKCD0.32948652
140RPS6KA50.32816147
141IGF1R0.32678704
142IKBKB0.32132116
143MAP3K20.31831839
144PDK10.31617550
145MELK0.31336352
146MAP3K120.30655559
147DDR20.30594875
148ABL10.30475822
149PRKCI0.30236172
150PRKCE0.29813280
151SGK30.29513441
152PTK2B0.29280581
153BMX0.29016806
154PLK20.28489857
155PRKCA0.28450785
156RET0.27926821
157CAMK2D0.26777777
158PRKCG0.26027534
159PRKAA10.25311689
160TIE10.22369481
161LYN0.18773916
162BMPR20.18640578

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.22925614
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12767275
3Nitrogen metabolism_Homo sapiens_hsa009103.10041226
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04092046
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.86034747
6Arginine biosynthesis_Homo sapiens_hsa002202.67842606
7Tryptophan metabolism_Homo sapiens_hsa003802.61982837
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58203528
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57384759
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.55881440
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50861513
12Butanoate metabolism_Homo sapiens_hsa006502.43823894
13Complement and coagulation cascades_Homo sapiens_hsa046102.41426149
14Fatty acid degradation_Homo sapiens_hsa000712.35995113
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35178386
16Peroxisome_Homo sapiens_hsa041462.21363457
17Histidine metabolism_Homo sapiens_hsa003402.19126776
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10614370
19Asthma_Homo sapiens_hsa053102.06264070
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04470317
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02863003
22Steroid biosynthesis_Homo sapiens_hsa001002.01634024
23Propanoate metabolism_Homo sapiens_hsa006401.96681495
24Fatty acid elongation_Homo sapiens_hsa000621.93040640
25Fatty acid metabolism_Homo sapiens_hsa012121.86949428
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85644182
27Chemical carcinogenesis_Homo sapiens_hsa052041.79655678
28Sulfur metabolism_Homo sapiens_hsa009201.78581352
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.77557564
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77214405
31PPAR signaling pathway_Homo sapiens_hsa033201.74291335
32Phototransduction_Homo sapiens_hsa047441.67355270
33beta-Alanine metabolism_Homo sapiens_hsa004101.65201046
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64711533
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58032721
36Allograft rejection_Homo sapiens_hsa053301.54444256
37Caffeine metabolism_Homo sapiens_hsa002321.54314885
38Autoimmune thyroid disease_Homo sapiens_hsa053201.53613847
39Staphylococcus aureus infection_Homo sapiens_hsa051501.52584631
40Retinol metabolism_Homo sapiens_hsa008301.52179804
41Phenylalanine metabolism_Homo sapiens_hsa003601.51373241
42Bile secretion_Homo sapiens_hsa049761.48874716
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46495988
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44925161
45Pyruvate metabolism_Homo sapiens_hsa006201.44155339
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.42237510
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41350569
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39198457
49Graft-versus-host disease_Homo sapiens_hsa053321.37961238
50Tyrosine metabolism_Homo sapiens_hsa003501.37064479
51Type I diabetes mellitus_Homo sapiens_hsa049401.33281143
52Selenocompound metabolism_Homo sapiens_hsa004501.31455737
53Folate biosynthesis_Homo sapiens_hsa007901.26543750
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25647954
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22456246
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21255353
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20335587
58Starch and sucrose metabolism_Homo sapiens_hsa005001.15048885
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15041047
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.13055829
61Nicotine addiction_Homo sapiens_hsa050331.12574517
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.11311321
63Vitamin digestion and absorption_Homo sapiens_hsa049771.11020938
64Primary immunodeficiency_Homo sapiens_hsa053401.10619093
65Arginine and proline metabolism_Homo sapiens_hsa003301.10156253
66ABC transporters_Homo sapiens_hsa020101.08653586
67Fat digestion and absorption_Homo sapiens_hsa049751.03011565
68Carbon metabolism_Homo sapiens_hsa012001.01839942
69Biosynthesis of amino acids_Homo sapiens_hsa012301.00687073
70Vitamin B6 metabolism_Homo sapiens_hsa007501.00221886
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99107387
72Taste transduction_Homo sapiens_hsa047420.98453165
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.93690751
74Glutathione metabolism_Homo sapiens_hsa004800.88257636
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85917811
76Viral myocarditis_Homo sapiens_hsa054160.82479235
77Morphine addiction_Homo sapiens_hsa050320.81030383
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80023502
79Sulfur relay system_Homo sapiens_hsa041220.75233574
80Renin secretion_Homo sapiens_hsa049240.74040470
81Serotonergic synapse_Homo sapiens_hsa047260.73593470
82Olfactory transduction_Homo sapiens_hsa047400.71600655
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70164839
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68232835
85Glycerolipid metabolism_Homo sapiens_hsa005610.68068429
86Glutamatergic synapse_Homo sapiens_hsa047240.67112235
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65944368
88Systemic lupus erythematosus_Homo sapiens_hsa053220.63974915
89Calcium signaling pathway_Homo sapiens_hsa040200.61660990
90Antigen processing and presentation_Homo sapiens_hsa046120.60438678
91Insulin secretion_Homo sapiens_hsa049110.59259649
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57884724
93GABAergic synapse_Homo sapiens_hsa047270.56577246
94Long-term depression_Homo sapiens_hsa047300.56504085
95Rheumatoid arthritis_Homo sapiens_hsa053230.56422810
96Salivary secretion_Homo sapiens_hsa049700.53797185
97Lysine degradation_Homo sapiens_hsa003100.53467906
98Circadian entrainment_Homo sapiens_hsa047130.53100336
99Metabolic pathways_Homo sapiens_hsa011000.50818089
100Fatty acid biosynthesis_Homo sapiens_hsa000610.47292057
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45318645
102Pentose phosphate pathway_Homo sapiens_hsa000300.45231248
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45054547
104Dorso-ventral axis formation_Homo sapiens_hsa043200.44404231
105Hematopoietic cell lineage_Homo sapiens_hsa046400.42209146
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.41388821
107Prion diseases_Homo sapiens_hsa050200.41359135
108Dopaminergic synapse_Homo sapiens_hsa047280.40911862
109Pancreatic secretion_Homo sapiens_hsa049720.38644375
110Linoleic acid metabolism_Homo sapiens_hsa005910.37998555
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36476835
112Phagosome_Homo sapiens_hsa041450.32830918
113Cholinergic synapse_Homo sapiens_hsa047250.31496446
114Oxytocin signaling pathway_Homo sapiens_hsa049210.29840291
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.25024280
116Ether lipid metabolism_Homo sapiens_hsa005650.24087599
117Fructose and mannose metabolism_Homo sapiens_hsa000510.23851915
118One carbon pool by folate_Homo sapiens_hsa006700.22249227
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21689908
120Lysosome_Homo sapiens_hsa041420.20194841
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.19092922
122Galactose metabolism_Homo sapiens_hsa000520.09396261
123Insulin resistance_Homo sapiens_hsa049310.08960568
124Mineral absorption_Homo sapiens_hsa049780.07290683
125Arachidonic acid metabolism_Homo sapiens_hsa005900.06240646
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05968530
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01713691
128Renin-angiotensin system_Homo sapiens_hsa046140.01524100
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.00560920
130Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1271802
131Glucagon signaling pathway_Homo sapiens_hsa04922-0.1221901
132African trypanosomiasis_Homo sapiens_hsa05143-0.1214814
133Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1164258
134Protein digestion and absorption_Homo sapiens_hsa04974-0.1020444
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0904597
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0815280
137Collecting duct acid secretion_Homo sapiens_hsa04966-0.0708483
138AMPK signaling pathway_Homo sapiens_hsa04152-0.0641933
139Hepatitis C_Homo sapiens_hsa05160-0.0639570
140Oxidative phosphorylation_Homo sapiens_hsa00190-0.0531681
141Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0513288
142Sphingolipid metabolism_Homo sapiens_hsa00600-0.0318628
143Other glycan degradation_Homo sapiens_hsa00511-0.0296931
144Regulation of autophagy_Homo sapiens_hsa04140-0.0205490

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