TMEM190

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.45990837
2cilium or flagellum-dependent cell motility (GO:0001539)9.43129223
3axonemal dynein complex assembly (GO:0070286)9.40093202
4spermatid development (GO:0007286)9.33481541
5epithelial cilium movement (GO:0003351)9.13959404
6motile cilium assembly (GO:0044458)8.54772497
7primary alcohol catabolic process (GO:0034310)8.42726892
8regulation of cilium movement (GO:0003352)7.98152523
9cilium movement (GO:0003341)7.74782896
10sperm capacitation (GO:0048240)7.53755432
11synaptonemal complex assembly (GO:0007130)7.48645480
12male meiosis (GO:0007140)7.43956226
13synaptonemal complex organization (GO:0070193)7.41542696
14single fertilization (GO:0007338)7.30986001
15vitamin transmembrane transport (GO:0035461)7.04081504
16ethanol metabolic process (GO:0006067)7.01946563
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.94457838
18left/right axis specification (GO:0070986)6.57076261
19piRNA metabolic process (GO:0034587)6.47682870
20organic cation transport (GO:0015695)6.40026284
21diterpenoid biosynthetic process (GO:0016102)6.39392248
22microtubule bundle formation (GO:0001578)6.38282986
23spermatogenesis (GO:0007283)6.35993875
24male gamete generation (GO:0048232)6.33704360
25fertilization (GO:0009566)6.19781359
26negative regulation of inclusion body assembly (GO:0090084)6.12198276
27gamete generation (GO:0007276)5.81371167
28one-carbon compound transport (GO:0019755)5.69712899
29tolerance induction (GO:0002507)5.56505457
30ethanol oxidation (GO:0006069)5.48615584
31pyrimidine-containing compound transmembrane transport (GO:0072531)5.47327915
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.46962308
33microtubule severing (GO:0051013)5.43798977
34ventricular system development (GO:0021591)5.36571439
35lung epithelium development (GO:0060428)5.36033244
36centriole assembly (GO:0098534)5.34669232
37regulation of inclusion body assembly (GO:0090083)5.26230157
38microtubule depolymerization (GO:0007019)5.20289550
39spermatid nucleus differentiation (GO:0007289)5.19948902
40germ cell development (GO:0007281)5.18606847
41calcium ion-dependent exocytosis (GO:0017156)5.17744312
42cell recognition (GO:0008037)5.14976231
43establishment of apical/basal cell polarity (GO:0035089)5.14761895
44chromosome organization involved in meiosis (GO:0070192)5.04504273
45response to xenobiotic stimulus (GO:0009410)4.99628590
46glomerular epithelial cell development (GO:0072310)4.98587442
47negative regulation of T cell differentiation in thymus (GO:0033085)4.96703672
48chromosome condensation (GO:0030261)4.85627864
49negative regulation of B cell mediated immunity (GO:0002713)4.84709886
50negative regulation of immunoglobulin mediated immune response (GO:0002890)4.84709886
51negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.84022173
52seminiferous tubule development (GO:0072520)4.77665837
53male meiosis I (GO:0007141)4.77563384
54regulation of microtubule-based movement (GO:0060632)4.66575116
55DNA packaging (GO:0006323)4.64072882
56multicellular organismal reproductive process (GO:0048609)4.56929518
57retinoic acid metabolic process (GO:0042573)4.55507808
58establishment or maintenance of monopolar cell polarity (GO:0061339)4.50623942
59establishment of monopolar cell polarity (GO:0061162)4.50623942
60negative regulation of humoral immune response (GO:0002921)4.48578594
61terpenoid biosynthetic process (GO:0016114)4.48342719
62positive regulation of tolerance induction (GO:0002645)4.42370323
63regulation of germinal center formation (GO:0002634)4.41081630
64meiotic nuclear division (GO:0007126)4.37719511
65regulation of interleukin-5 production (GO:0032674)4.37193392
66monoubiquitinated protein deubiquitination (GO:0035520)4.32027551
67sequestering of actin monomers (GO:0042989)4.27033766
68glycerol ether metabolic process (GO:0006662)4.24182392
69DNA methylation involved in gamete generation (GO:0043046)4.17016127
70protein polyglutamylation (GO:0018095)4.11099026
71cell projection assembly (GO:0030031)4.08394899
72regulation of interleukin-13 production (GO:0032656)4.01986919
73left/right pattern formation (GO:0060972)3.93471048
74ether metabolic process (GO:0018904)3.90081297
75cytoplasmic microtubule organization (GO:0031122)3.88856661
76meiosis I (GO:0007127)3.85712955
77genitalia morphogenesis (GO:0035112)3.75799404
78primary alcohol metabolic process (GO:0034308)3.68556784
79chaperone-mediated protein complex assembly (GO:0051131)3.67711541
80multicellular organismal development (GO:0007275)3.66324273
81retinol metabolic process (GO:0042572)3.64064771
82exogenous drug catabolic process (GO:0042738)3.61996362
83positive regulation of macrophage activation (GO:0043032)3.54795092
84regulation of spindle checkpoint (GO:0090231)3.49910899
85establishment of planar polarity (GO:0001736)3.48542843
86establishment of tissue polarity (GO:0007164)3.48542843
87sexual reproduction (GO:0019953)3.43340250
88multicellular organismal water homeostasis (GO:0050891)3.37945332
89glutathione derivative biosynthetic process (GO:1901687)3.36783462
90glutathione derivative metabolic process (GO:1901685)3.36783462
91regulation of tolerance induction (GO:0002643)3.31308333
92single strand break repair (GO:0000012)3.30909925
93O-glycan processing (GO:0016266)3.25846895
94amino-acid betaine transport (GO:0015838)3.21820838
95carnitine transport (GO:0015879)3.21820838
96protein K11-linked deubiquitination (GO:0035871)3.21480798
97protein localization to cilium (GO:0061512)3.21398072
98interferon-gamma secretion (GO:0072643)3.20004327
99hydrogen peroxide biosynthetic process (GO:0050665)3.18411870
100regulation of microtubule depolymerization (GO:0031114)3.12717577
101lateral ventricle development (GO:0021670)3.12717107
102carnitine transmembrane transport (GO:1902603)3.10277636
103aldehyde catabolic process (GO:0046185)3.10017325
104positive regulation of smoothened signaling pathway (GO:0045880)3.08611270
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01789615
106meiotic cell cycle (GO:0051321)3.00078817
107synapsis (GO:0007129)2.96503700
108nucleus organization (GO:0006997)2.94892486
109protein refolding (GO:0042026)2.94764926
110progesterone metabolic process (GO:0042448)2.92353027
111negative regulation of organelle assembly (GO:1902116)2.90215554
112meiotic cell cycle process (GO:1903046)2.88220900
113water homeostasis (GO:0030104)2.86416417
114hydrogen peroxide catabolic process (GO:0042744)2.86006371
115phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.85271013
116reactive oxygen species biosynthetic process (GO:1903409)2.82640677
117mitotic sister chromatid cohesion (GO:0007064)2.82098191
118oligosaccharide biosynthetic process (GO:0009312)2.81972296
119excretion (GO:0007588)2.80996548
120glycolytic process (GO:0006096)2.78249378
121RNA localization (GO:0006403)2.76815722
122drug catabolic process (GO:0042737)2.75555669
123centriole replication (GO:0007099)2.75138642
124intraciliary transport (GO:0042073)2.74842545
125lactate metabolic process (GO:0006089)2.73253837
126hypotonic response (GO:0006971)2.73118534
127carnitine metabolic process (GO:0009437)2.73024312
128microtubule-based process (GO:0007017)2.69692606
129lateral sprouting from an epithelium (GO:0060601)2.67036266
130regulation of response to osmotic stress (GO:0047484)2.66931802
131microtubule-based movement (GO:0007018)2.65740670
132peptidyl-glutamic acid modification (GO:0018200)2.65238173
133nucleoside diphosphate phosphorylation (GO:0006165)2.63770771
134axoneme assembly (GO:0035082)2.63646161
135phosphatidylcholine biosynthetic process (GO:0006656)2.63160478
136determination of left/right symmetry (GO:0007368)2.61577214
137calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.60078585
138cilium organization (GO:0044782)2.59007253
139nuclear pore complex assembly (GO:0051292)2.58974283
140polyamine biosynthetic process (GO:0006596)2.58755391
141apical protein localization (GO:0045176)2.57664796
142regulation of autophagic vacuole assembly (GO:2000785)2.57413085
143regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.57330293
144cellular component assembly involved in morphogenesis (GO:0010927)2.57135843
145dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.55692863
146negative regulation of microtubule depolymerization (GO:0007026)2.52974014
147GTP biosynthetic process (GO:0006183)2.50523271
148determination of bilateral symmetry (GO:0009855)2.50454631
149glutathione metabolic process (GO:0006749)2.50432283
150polyol transport (GO:0015791)2.50216139
151phosphatidylethanolamine biosynthetic process (GO:0006646)2.50122945
152microtubule polymerization or depolymerization (GO:0031109)2.49376970
153hydrogen peroxide metabolic process (GO:0042743)2.49087087
154organelle assembly (GO:0070925)2.49000383
155histone exchange (GO:0043486)2.48796770
156peptidyl-lysine dimethylation (GO:0018027)2.48680800
157smoothened signaling pathway (GO:0007224)2.46486616
158regulation of centriole replication (GO:0046599)2.46471325
159RNA destabilization (GO:0050779)2.44487733
160gene silencing by RNA (GO:0031047)2.44323138
161polyol catabolic process (GO:0046174)2.44309892
162cilium morphogenesis (GO:0060271)2.42436715
163cilium assembly (GO:0042384)2.41201703
164protein-DNA complex disassembly (GO:0032986)2.39407616
165cell wall macromolecule catabolic process (GO:0016998)13.9909739
166cell wall macromolecule metabolic process (GO:0044036)13.9909739
167fusion of sperm to egg plasma membrane (GO:0007342)13.4089693
168acrosome assembly (GO:0001675)13.2097865
169sperm motility (GO:0030317)12.9846310
170sperm-egg recognition (GO:0035036)12.2055124
171acrosome reaction (GO:0007340)11.5002084
172multicellular organism reproduction (GO:0032504)11.1817671
173binding of sperm to zona pellucida (GO:0007339)10.9731646
174cell-cell recognition (GO:0009988)10.9424776
175plasma membrane fusion (GO:0045026)10.1468563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.87952048
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.54644711
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.33216035
4DROSHA_22980978_ChIP-Seq_HELA_Human3.32689048
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.11472026
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.07964896
7EZH2_22144423_ChIP-Seq_EOC_Human3.04775810
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.89058179
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.54481206
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.53514841
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48969863
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28788884
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.21973371
14SMC4_20622854_ChIP-Seq_HELA_Human2.11042750
15RUNX1_27514584_Chip-Seq_MCF-7_Human2.06600587
16ZNF274_21170338_ChIP-Seq_K562_Hela2.06084245
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.02849091
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00596290
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.00014710
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2855699
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.99498842
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.92192898
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.91376633
24FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90236203
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89997213
26STAT1_20625510_ChIP-Seq_HELA_Human1.85779568
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.84527160
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.83870764
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.80845348
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.79682793
31AHR_22903824_ChIP-Seq_MCF-7_Human1.79218758
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.74648078
33TP63_22573176_ChIP-Seq_HFKS_Human1.72333968
34P63_26484246_Chip-Seq_KERATINOCYTES_Human1.71620260
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71367976
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67933757
37GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.67552196
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.67051151
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65928891
40STAT1_17558387_ChIP-Seq_HELA_Human1.65547784
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65244978
42VDR_22108803_ChIP-Seq_LS180_Human1.60380306
43KLF5_25053715_ChIP-Seq_YYC3_Human1.60147092
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.58434727
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.57515401
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.56787527
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.56232857
48TP63_23658742_ChIP-Seq_EP156T_Human1.54883091
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52960644
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.51361018
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51297997
52P68_20966046_ChIP-Seq_HELA_Human1.48535214
53* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.48471852
54CBP_20019798_ChIP-Seq_JUKART_Human1.46256326
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46256326
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.44949516
57CTCF_27219007_Chip-Seq_Bcells_Human1.44036756
58GATA1_19941826_ChIP-Seq_K562_Human1.43890127
59P53_21459846_ChIP-Seq_SAOS-2_Human1.42814566
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42086701
61LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.41010999
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40896734
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40377603
64SOX2_20726797_ChIP-Seq_SW620_Human1.40321236
65RACK7_27058665_Chip-Seq_MCF-7_Human1.39664950
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.39007078
67FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38533667
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37646926
69FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31785137
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31638994
71ETV1_20927104_ChIP-Seq_GIST48_Human1.31147981
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30803117
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.30262463
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.29719045
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.29085125
76LXR_22292898_ChIP-Seq_THP-1_Human1.28632743
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.27205218
78CREB1_26743006_Chip-Seq_LNCaP_Human1.27077336
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26712844
80GATA3_21867929_ChIP-Seq_TH1_Mouse1.25984158
81FOXA1_25552417_ChIP-Seq_VCAP_Human1.25970142
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23819890
83KDM2B_26808549_Chip-Seq_REH_Human1.23011223
84RARA_24833708_ChIP-Seq_LIVER_Mouse1.22877040
85RUNX1_26923725_Chip-Seq_HPCs_Mouse1.22004345
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21906581
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21786305
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.21677586
89SMRT_27268052_Chip-Seq_Bcells_Human1.20967930
90ERG_20517297_ChIP-Seq_VCAP_Human1.20088832
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19999621
92SPI1_26923725_Chip-Seq_HPCs_Mouse1.19847667
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.19581443
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19501025
95HNFA_21074721_ChIP-Seq_CACO-2_Human1.19287001
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19144345
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18970912
98TP53_18474530_ChIP-ChIP_U2OS_Human1.18846556
99GF1_26923725_Chip-Seq_HPCs_Mouse1.18395075
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.17735291
101PHF8_20622853_ChIP-Seq_HELA_Human1.16227142
102* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16152486
103EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16061504
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15643203
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.15061505
106RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14633789
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14346463
108SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13967707
109SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13581137
110CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13318161
111E2F1_20622854_ChIP-Seq_HELA_Human1.13268842
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.12067737
113GATA3_24758297_ChIP-Seq_MCF-7_Human1.12003790
114RBPJ_21746931_ChIP-Seq_IB4_Human1.11985204
115* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11489341
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11164354
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10751912
118GATA4_25053715_ChIP-Seq_YYC3_Human1.10577800
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10349532
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10102284
121P300_27268052_Chip-Seq_Bcells_Human1.09527923
122FOXO3_23340844_ChIP-Seq_DLD1_Human1.09348715
123LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07093752
124SA1_27219007_Chip-Seq_ERYTHROID_Human1.06332366
125YY1_22570637_ChIP-Seq_MALME-3M_Human1.06046204
126CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05444012
127ESET_19884257_ChIP-Seq_ESCs_Mouse1.04302532
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.04104928
129CEBPB_22108803_ChIP-Seq_LS180_Human1.03959413
130GATA6_21074721_ChIP-Seq_CACO-2_Human1.02544598
131GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02340487
132PHF8_20622854_ChIP-Seq_HELA_Human1.01972358
133BCOR_27268052_Chip-Seq_Bcells_Human1.00696048
134CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00323677
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00085093
136RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00041013
137GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99715312
138FOXA2_19822575_ChIP-Seq_HepG2_Human0.99530454
139OCT4_18555785_Chip-Seq_ESCs_Mouse0.99203324
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98587993
141TP63_17297297_ChIP-ChIP_HaCaT_Human0.97978477
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97881222
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97641238
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97516912
145FLI1_21867929_ChIP-Seq_CD8_Mouse0.97441326
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97193350
147ZNF263_19887448_ChIP-Seq_K562_Human0.96216949
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95658650
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94950961
150MYC_27129775_Chip-Seq_CORNEA_Mouse0.94088067
151SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93661749
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93465749
153NANOG_18555785_Chip-Seq_ESCs_Mouse0.92870567
154BCL6_27268052_Chip-Seq_Bcells_Human0.92718163
155PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91311103
156NFYA_21822215_ChIP-Seq_K562_Human0.91047263
157P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.90777018
158RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90710458
159SOX2_21211035_ChIP-Seq_LN229_Human0.90080241
160ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89911779
161GATA2_19941826_ChIP-Seq_K562_Human0.89133482
162POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88656992
163TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88656992
164SA1_27219007_Chip-Seq_Bcells_Human0.88561034
165CTCF_26484167_Chip-Seq_Bcells_Mouse0.88504604
166TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88471580
167KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88432902
168RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88318866
169CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88295475
170KLF4_18555785_Chip-Seq_ESCs_Mouse0.87890762
171EZH2_27294783_Chip-Seq_ESCs_Mouse0.87716155
172VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87592424
173P53_22387025_ChIP-Seq_ESCs_Mouse0.87321024
174* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87268830
175OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86995420
176JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.86776128
177RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86254576
178SPI1_20517297_ChIP-Seq_HL60_Human0.85696492
179SMAD3_21741376_ChIP-Seq_HESCs_Human0.85617219
180TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85448873
181CTCF_20526341_ChIP-Seq_ESCs_Human0.85277798
182CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83877751
183REST_21632747_ChIP-Seq_MESCs_Mouse0.83631453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.92147581
2MP0001929_abnormal_gametogenesis5.49579307
3MP0009780_abnormal_chondrocyte_physiolo3.98859750
4MP0008877_abnormal_DNA_methylation3.86271670
5MP0002277_abnormal_respiratory_mucosa3.48423599
6MP0008789_abnormal_olfactory_epithelium3.38457261
7MP0002210_abnormal_sex_determination3.35598726
8MP0002161_abnormal_fertility/fecundity3.16943062
9MP0001145_abnormal_male_reproductive2.95171898
10MP0000566_synostosis2.73896814
11MP0000653_abnormal_sex_gland2.56305582
12MP0002653_abnormal_ependyma_morphology2.51262291
13MP0005394_taste/olfaction_phenotype2.25635082
14MP0005499_abnormal_olfactory_system2.25635082
15MP0005670_abnormal_white_adipose2.15834628
16MP0002168_other_aberrant_phenotype2.04575938
17MP0000383_abnormal_hair_follicle2.00208496
18MP0005410_abnormal_fertilization16.1821781
19MP0002160_abnormal_reproductive_system1.94807161
20MP0000678_abnormal_parathyroid_gland1.93250250
21MP0005623_abnormal_meninges_morphology1.87811656
22MP0010678_abnormal_skin_adnexa1.85258353
23MP0003646_muscle_fatigue1.78818282
24MP0010234_abnormal_vibrissa_follicle1.69705946
25MP0004233_abnormal_muscle_weight1.54471853
26MP0005165_increased_susceptibility_to1.50731237
27MP0001346_abnormal_lacrimal_gland1.48004651
28MP0005248_abnormal_Harderian_gland1.44673367
29MP0002249_abnormal_larynx_morphology1.39064572
30MP0010155_abnormal_intestine_physiology1.36205749
31MP0005395_other_phenotype1.35004283
32MP0008058_abnormal_DNA_repair1.33073209
33MP0009379_abnormal_foot_pigmentation1.27276429
34MP0000465_gastrointestinal_hemorrhage1.20871702
35MP0002282_abnormal_trachea_morphology1.14464358
36MP0001765_abnormal_ion_homeostasis1.09827821
37MP0003303_peritoneal_inflammation1.07566609
38MP0004264_abnormal_extraembryonic_tissu1.06605214
39MP0002734_abnormal_mechanical_nocicepti1.06211071
40MP0000681_abnormal_thyroid_gland1.03035296
41MP0005408_hypopigmentation1.01147171
42MP0002735_abnormal_chemical_nociception1.00879408
43MP0010030_abnormal_orbit_morphology1.00455832
44MP0005647_abnormal_sex_gland0.99794352
45MP0009046_muscle_twitch0.97815210
46MP0002638_abnormal_pupillary_reflex0.95733118
47MP0005164_abnormal_response_to0.95528954
48MP0005389_reproductive_system_phenotype0.92209833
49MP0002876_abnormal_thyroid_physiology0.91867380
50MP0001545_abnormal_hematopoietic_system0.91243253
51MP0005397_hematopoietic_system_phenotyp0.91243253
52MP0002233_abnormal_nose_morphology0.90906044
53MP0009643_abnormal_urine_homeostasis0.90569431
54MP0010094_abnormal_chromosome_stability0.84133004
55MP0003453_abnormal_keratinocyte_physiol0.83692891
56MP0002136_abnormal_kidney_physiology0.83342131
57MP0005310_abnormal_salivary_gland0.82767461
58MP0006036_abnormal_mitochondrial_physio0.82218617
59MP0000858_altered_metastatic_potential0.82191743
60MP0004883_abnormal_blood_vessel0.81807883
61MP0001984_abnormal_olfaction0.81426861
62MP0001485_abnormal_pinna_reflex0.77818479
63MP0005409_darkened_coat_color0.76394836
64MP0002098_abnormal_vibrissa_morphology0.75007791
65MP0002928_abnormal_bile_duct0.74732558
66MP0005636_abnormal_mineral_homeostasis0.73808872
67MP0000467_abnormal_esophagus_morphology0.72095485
68MP0008007_abnormal_cellular_replicative0.71070622
69MP0009765_abnormal_xenobiotic_induced0.69577741
70MP0003075_altered_response_to0.68401150
71MP0003011_delayed_dark_adaptation0.68189140
72MP0004036_abnormal_muscle_relaxation0.67712961
73MP0005220_abnormal_exocrine_pancreas0.67546237
74MP0002234_abnormal_pharynx_morphology0.67132468
75MP0000358_abnormal_cell_content/0.65817938
76MP0002822_catalepsy0.65658653
77MP0005085_abnormal_gallbladder_physiolo0.64902950
78MP0008057_abnormal_DNA_replication0.62476536
79MP0003115_abnormal_respiratory_system0.60728370
80MP0005503_abnormal_tendon_morphology0.60487711
81MP0003136_yellow_coat_color0.60075229
82MP0009763_increased_sensitivity_to0.59705321
83MP0003866_abnormal_defecation0.59580785
84MP0001188_hyperpigmentation0.59427499
85MP0001270_distended_abdomen0.58306913
86MP0009278_abnormal_bone_marrow0.56524765
87MP0010307_abnormal_tumor_latency0.54480714
88MP0003950_abnormal_plasma_membrane0.54024077
89MP0003111_abnormal_nucleus_morphology0.53959960
90MP0003699_abnormal_female_reproductive0.53918357
91MP0005365_abnormal_bile_salt0.52791249
92MP0002269_muscular_atrophy0.52265331
93MP0004808_abnormal_hematopoietic_stem0.51863560
94MP0001664_abnormal_digestion0.51646436
95MP0001663_abnormal_digestive_system0.51553237
96MP0005023_abnormal_wound_healing0.50755217
97MP0001730_embryonic_growth_arrest0.50111818
98MP0005377_hearing/vestibular/ear_phenot0.49056666
99MP0003878_abnormal_ear_physiology0.49056666
100MP0001502_abnormal_circadian_rhythm0.48848285
101MP0000026_abnormal_inner_ear0.48210615
102MP0001299_abnormal_eye_distance/0.47761641
103MP0004084_abnormal_cardiac_muscle0.47415271
104MP0008995_early_reproductive_senescence0.46688916
105MP0006082_CNS_inflammation0.46013568
106MP0005166_decreased_susceptibility_to0.45522197
107MP0001666_abnormal_nutrient_absorption0.45512461
108MP0001293_anophthalmia0.45095589
109MP0009703_decreased_birth_body0.44397795
110MP0002896_abnormal_bone_mineralization0.43891658
111MP0003656_abnormal_erythrocyte_physiolo0.43276216
112MP0001944_abnormal_pancreas_morphology0.41681566
113MP0002116_abnormal_craniofacial_bone0.41596104
114MP0002133_abnormal_respiratory_system0.41290935
115MP0005388_respiratory_system_phenotype0.41290935
116MP0003806_abnormal_nucleotide_metabolis0.40808273
117MP0002139_abnormal_hepatobiliary_system0.39688259
118MP0004043_abnormal_pH_regulation0.39473809
119MP0001324_abnormal_eye_pigmentation0.39063762
120MP0000313_abnormal_cell_death0.39006322
121MP0001970_abnormal_pain_threshold0.38948350
122MP0002229_neurodegeneration0.38731801
123MP0002132_abnormal_respiratory_system0.37412643
124MP0002135_abnormal_kidney_morphology0.37302860
125MP0008961_abnormal_basal_metabolism0.36837564
126MP0005666_abnormal_adipose_tissue0.36811135
127MP0005083_abnormal_biliary_tract0.35683669
128MP0003786_premature_aging0.34547516
129MP0003329_amyloid_beta_deposits0.34355948
130MP0009115_abnormal_fat_cell0.32584277
131MP0006035_abnormal_mitochondrial_morpho0.31549038
132MP0003252_abnormal_bile_duct0.31293409
133MP0000751_myopathy0.30863313
134MP0003943_abnormal_hepatobiliary_system0.30776495
135MP0005319_abnormal_enzyme/_coenzyme0.30425748
136MP0004019_abnormal_vitamin_homeostasis0.28806893
137MP0001697_abnormal_embryo_size0.27771020
138MP0001119_abnormal_female_reproductive0.27492733
139MP0003077_abnormal_cell_cycle0.26895431
140MP0009697_abnormal_copulation0.26736584
141MP0008875_abnormal_xenobiotic_pharmacok0.26513556
142MP0002405_respiratory_system_inflammati0.25952738
143MP0002084_abnormal_developmental_patter0.25869452
144MP0000569_abnormal_digit_pigmentation0.25114771
145MP0001764_abnormal_homeostasis0.24777637
146MP0002971_abnormal_brown_adipose0.24662082
147MP0000534_abnormal_ureter_morphology0.24643716
148MP0000462_abnormal_digestive_system0.23883329
149MP0002080_prenatal_lethality0.23442625
150MP0001849_ear_inflammation0.23030294
151MP0004133_heterotaxia0.22860480
152MP0003633_abnormal_nervous_system0.21685544
153MP0005174_abnormal_tail_pigmentation0.21531298
154MP0005391_vision/eye_phenotype0.20847030
155MP0005360_urolithiasis0.20790533
156MP0002092_abnormal_eye_morphology0.20303315
157MP0006054_spinal_hemorrhage0.20035259
158MP0002169_no_abnormal_phenotype0.19899741
159MP0002873_normal_phenotype0.19603148
160MP0001348_abnormal_lacrimal_gland0.19419747
161MP0002909_abnormal_adrenal_gland0.19344908
162MP0001672_abnormal_embryogenesis/_devel0.19094399
163MP0005380_embryogenesis_phenotype0.19094399
164MP0002693_abnormal_pancreas_physiology0.19089069
165MP0000609_abnormal_liver_physiology0.18610955
166MP0010630_abnormal_cardiac_muscle0.18225076
167MP0004957_abnormal_blastocyst_morpholog0.18145287
168MP0003183_abnormal_peptide_metabolism0.18041263
169MP0002118_abnormal_lipid_homeostasis0.17708735
170MP0009672_abnormal_birth_weight0.16277656

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.42728629
2Abnormal respiratory epithelium morphology (HP:0012253)8.50422367
3Abnormal respiratory motile cilium morphology (HP:0005938)8.50422367
4Rhinitis (HP:0012384)7.89182136
5Chronic bronchitis (HP:0004469)7.59116725
6Abnormal ciliary motility (HP:0012262)7.53861550
7Nasal polyposis (HP:0100582)6.91155072
8Infertility (HP:0000789)6.66292486
9Abnormality of the nasal mucosa (HP:0000433)5.70813413
10Bronchitis (HP:0012387)4.90045364
11Bronchiectasis (HP:0002110)4.67556323
12Male infertility (HP:0003251)4.66035977
13Nephronophthisis (HP:0000090)4.44407647
14Abnormal spermatogenesis (HP:0008669)4.04163000
15Occipital encephalocele (HP:0002085)3.46191262
16Recurrent sinusitis (HP:0011108)3.38470978
17Recurrent otitis media (HP:0000403)3.36420404
18Abnormality of the renal medulla (HP:0100957)3.30048965
19Hyperactive renin-angiotensin system (HP:0000841)3.23217651
20Atelectasis (HP:0100750)3.15325636
21True hermaphroditism (HP:0010459)3.12537728
22Recurrent bronchitis (HP:0002837)3.10664456
23Chronic otitis media (HP:0000389)3.08742012
24Tubular atrophy (HP:0000092)2.96919310
25Molar tooth sign on MRI (HP:0002419)2.92440042
26Abnormality of midbrain morphology (HP:0002418)2.92440042
27Azoospermia (HP:0000027)2.90100568
28Tubulointerstitial nephritis (HP:0001970)2.75841950
29Tubulointerstitial abnormality (HP:0001969)2.66347918
30Pancreatic cysts (HP:0001737)2.51961411
31Tubulointerstitial fibrosis (HP:0005576)2.43836220
32Abnormal gallbladder physiology (HP:0012438)2.43224994
33Cholecystitis (HP:0001082)2.43224994
34Medial flaring of the eyebrow (HP:0010747)2.37233719
35Impulsivity (HP:0100710)2.33647989
36Chronic hepatic failure (HP:0100626)2.17178139
37Abnormal drinking behavior (HP:0030082)2.14713430
38Polydipsia (HP:0001959)2.14713430
39Gonadotropin excess (HP:0000837)2.02696017
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6596008
41Absent/shortened dynein arms (HP:0200106)12.4166218
42Dynein arm defect of respiratory motile cilia (HP:0012255)12.4166218
43Renal salt wasting (HP:0000127)1.99423190
44Dyschromatopsia (HP:0007641)1.94629236
45Abnormality of renal excretion (HP:0011036)1.87980601
46Decreased circulating renin level (HP:0003351)1.87919999
47Congenital hepatic fibrosis (HP:0002612)1.87268946
48Anencephaly (HP:0002323)1.86681688
49Stage 5 chronic kidney disease (HP:0003774)1.85038253
50Postaxial foot polydactyly (HP:0001830)1.84528914
51Abnormality of the renal cortex (HP:0011035)1.82180565
52Hyperkalemia (HP:0002153)1.81112275
53Male pseudohermaphroditism (HP:0000037)1.80072506
54Abnormality of the lower motor neuron (HP:0002366)1.77192219
55Tongue fasciculations (HP:0001308)1.76394867
56J-shaped sella turcica (HP:0002680)1.76178415
57Aplasia/Hypoplasia of the spleen (HP:0010451)1.74777315
58Absent frontal sinuses (HP:0002688)1.74658616
59Asplenia (HP:0001746)1.74554813
60Asymmetric septal hypertrophy (HP:0001670)1.72611892
61Short ribs (HP:0000773)1.70586962
62Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69423399
63Fibular hypoplasia (HP:0003038)1.68068029
64Abnormality of saccadic eye movements (HP:0000570)1.66677795
65Decreased central vision (HP:0007663)1.65582687
66Deformed sella turcica (HP:0002681)1.65119189
67Pancreatic fibrosis (HP:0100732)1.62945036
68Spastic tetraparesis (HP:0001285)1.62556779
69Microglossia (HP:0000171)1.62037304
70Oculomotor apraxia (HP:0000657)1.60913578
71Hyperaldosteronism (HP:0000859)1.59516096
72Muscle fibrillation (HP:0010546)1.58196013
73Choroideremia (HP:0001139)1.56681642
74Abnormal urine output (HP:0012590)1.55725873
75Abnormal biliary tract physiology (HP:0012439)1.55119141
76Bile duct proliferation (HP:0001408)1.55119141
77Heterotopia (HP:0002282)1.53563626
78Cystic liver disease (HP:0006706)1.53389861
79Renal dysplasia (HP:0000110)1.52820719
80Congenital primary aphakia (HP:0007707)1.52807596
81Sclerocornea (HP:0000647)1.52547740
82Abnormality of chloride homeostasis (HP:0011422)1.50639279
83Gait imbalance (HP:0002141)1.50162829
84Facial cleft (HP:0002006)1.49845141
85Furrowed tongue (HP:0000221)1.49046601
86Abnormality of renin-angiotensin system (HP:0000847)1.44516223
87Bundle branch block (HP:0011710)1.43010208
88Hand muscle atrophy (HP:0009130)1.42426195
89Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.41938657
90Abnormality of ocular smooth pursuit (HP:0000617)1.41919277
91Cerebellar dysplasia (HP:0007033)1.41475988
92Chronic sinusitis (HP:0011109)1.41375693
93Hemorrhage of the eye (HP:0011885)1.40915142
94Double outlet right ventricle (HP:0001719)1.38938241
95Congenital malformation of the right heart (HP:0011723)1.38938241
96Postaxial hand polydactyly (HP:0001162)1.38354271
97Median cleft lip (HP:0000161)1.37649998
98Abnormality of the dental root (HP:0006486)1.37326321
99Taurodontia (HP:0000679)1.37326321
100Abnormality of permanent molar morphology (HP:0011071)1.37326321
101Myoglobinuria (HP:0002913)1.36342345
102Polyuria (HP:0000103)1.35940458
103Difficulty climbing stairs (HP:0003551)1.35498516
104Easy fatigability (HP:0003388)1.34419953
105Abnormality of the distal phalanges of the toes (HP:0010182)1.33614238
106Amyotrophic lateral sclerosis (HP:0007354)1.33151532
107Aplasia/Hypoplasia of the tongue (HP:0010295)1.31964117
108Abnormality of dentin (HP:0010299)1.31939217
109Hyponatremia (HP:0002902)1.31803326
110Bell-shaped thorax (HP:0001591)1.31730830
111Nephrogenic diabetes insipidus (HP:0009806)1.31436433
112Hypokalemic alkalosis (HP:0001949)1.31187227
113Absent epiphyses (HP:0010577)1.30333032
114Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.30333032
115Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.30324294
116Short thorax (HP:0010306)1.29424597
117Abnormality of the dental pulp (HP:0006479)1.27176068
118Glucose intolerance (HP:0000833)1.26583233
119Abnormality of molar (HP:0011077)1.25975773
120Abnormality of molar morphology (HP:0011070)1.25975773
121Nephropathy (HP:0000112)1.25754898
122Fetal akinesia sequence (HP:0001989)1.25261301
123Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.23720311
124Abnormality of the frontal sinuses (HP:0002687)1.22591705
125Bifid scrotum (HP:0000048)1.21870354
126Impaired smooth pursuit (HP:0007772)1.21045040
127Exercise-induced myalgia (HP:0003738)1.20932299
128Short nail (HP:0001799)1.20061700
129Delayed gross motor development (HP:0002194)1.17803064
130Preaxial hand polydactyly (HP:0001177)1.16864129
131Broad distal phalanx of finger (HP:0009836)1.16508145
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.16256548
133Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.15600907
134Obstructive sleep apnea (HP:0002870)1.15238284
135Aplasia of the musculature (HP:0100854)1.14994581
136Popliteal pterygium (HP:0009756)1.13933002
137Cone-rod dystrophy (HP:0000548)1.13560075
138Short femoral neck (HP:0100864)1.12761779
139Stridor (HP:0010307)1.11563317
140Abnormality of monocarboxylic acid metabolism (HP:0010996)1.11493822
141Flat acetabular roof (HP:0003180)1.10590792
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.08929611
143Muscle fiber splitting (HP:0003555)1.05078158
144Distal upper limb amyotrophy (HP:0007149)1.04500787
145Upper limb amyotrophy (HP:0009129)1.04500787
146Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.02804944
147Poor coordination (HP:0002370)1.02773351
148Spinal muscular atrophy (HP:0007269)1.01803251
149Spinal cord compression (HP:0002176)1.00686429
150Vaginal atresia (HP:0000148)0.99967595
151Abnormality of sodium homeostasis (HP:0010931)0.99588868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.78619490
2PDK37.78619490
3TESK16.71053888
4MST45.36963157
5PDK24.90128080
6PRKD34.50394398
7ICK4.19974656
8PTK2B2.84395388
9SMG12.59177814
10WNK42.34158561
11NME12.31803973
12MAPKAPK32.28215208
13STK392.18056049
14STK382.11167046
15MAP3K22.08094699
16NEK22.01627817
17STK241.89998940
18MAP3K31.70196248
19CSK1.59215259
20EEF2K1.33794409
21DYRK1B1.30241021
22PNCK1.30212864
23PDK11.22902612
24LRRK21.20954717
25EPHB11.20455794
26DYRK31.18462297
27BCR1.12969132
28TLK11.11031900
29MAPK150.97075560
30PASK0.95523086
31MAP3K70.95281159
32BRSK20.94961647
33TBK10.89916561
34TRPM70.89467043
35WEE10.89436630
36TTK0.85988913
37PRKCI0.81706133
38PINK10.80030327
39EPHA30.78201236
40TYRO30.77976803
41PDPK10.77506312
42CCNB10.73047000
43CHEK20.71915707
44MAP3K120.71602983
45LMTK20.70754201
46RIPK10.69413373
47WNK10.67992217
48STK30.66282952
49PBK0.63499348
50STK160.63428725
51STK38L0.63387173
52ERBB30.62327613
53GRK60.62012325
54ERBB20.59334573
55TESK20.53175267
56CAMK2G0.49809099
57IRAK10.49217549
58MAP3K100.48260024
59BRSK10.45091968
60PRKAA20.44314740
61CHEK10.43221550
62CAMKK10.43082533
63SGK10.42772059
64PAK20.42751842
65TRIB30.42363530
66PAK10.42343562
67ATR0.42275574
68RPS6KB20.40527333
69INSRR0.39331049
70HIPK20.39268523
71MAP2K60.39106067
72ZAP700.39018099
73PAK40.38907289
74STK100.38448130
75MTOR0.36256597
76CAMK1G0.36237092
77BUB10.36139430
78CDC70.33287758
79ATM0.33098025
80MAPKAPK50.32418729
81PRKG20.32224024
82CDC42BPA0.30488415
83CSF1R0.29868809
84MAP2K20.27993533
85MUSK0.26706730
86PRKAA10.26091162
87ROCK20.25637450
88RPS6KA20.25631462
89PRKCG0.24765865
90PLK10.24134005
91IRAK20.23207295
92RIPK40.22394143
93MET0.22155978
94BRAF0.21744410
95MAP2K40.21677266
96EIF2AK10.21523887
97FER0.21304662
98TTN0.21243560
99MAP3K40.21020706
100FGFR30.20945797
101NLK0.20683298
102PRKACA0.20054911
103ROCK10.19985805
104RPS6KB10.19419507
105AKT20.19357823
106PRKCA0.19124565
107MAP3K110.19055124
108ABL10.18130306
109SRC0.16442072
110FYN0.15799539
111MARK20.15585580
112DYRK1A0.15451887
113MARK30.15087630
114ADRBK10.14872792
115MYLK0.14366658
116PIM20.14337385
117MAP2K70.14216904
118RPS6KA10.13880226
119MAP3K80.13315689
120AURKA0.12887680
121ABL20.12827978
122ERN10.12462381
123MATK0.11885786
124ARAF0.11689826
125PIM10.10966461
126ILK0.10929865
127ADRBK20.09962245
128PRKCZ0.09943425
129CDK60.09680767
130EGFR0.09601677
131PRKCQ0.09255579
132TYK20.08757056
133PRKCH0.08606472
134OXSR10.08431479
135CSNK2A10.08189102
136PRKD20.07946572
137CSNK2A20.07854719
138CDK20.07590634
139MAP4K10.07380379
140CDK40.06740971
141PDGFRB0.06172662
142PKN20.05703795
143EPHA20.04643657
144CDK10.04595476
145AURKB0.04352865
146MAPK80.04053467
147PRKACG0.03938183
148ACVR1B0.03650960
149TAOK10.03382086
150PTK60.03364425
151GSK3B0.02804845
152CDK150.02771825
153NTRK20.02488938
154PRKCD0.02204521
155MAP3K50.01251494
156CDK11A0.01016827
157PRKDC0.00443892
158NEK60.00381494
159MST1R0.00300314

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003605.45720256
2Histidine metabolism_Homo sapiens_hsa003404.80187108
3Tyrosine metabolism_Homo sapiens_hsa003504.37424391
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.24484492
5Fatty acid biosynthesis_Homo sapiens_hsa000614.15296989
6Pyruvate metabolism_Homo sapiens_hsa006203.69817902
7Vitamin B6 metabolism_Homo sapiens_hsa007503.55398342
8beta-Alanine metabolism_Homo sapiens_hsa004103.16027564
9Pentose phosphate pathway_Homo sapiens_hsa000303.04842113
10Propanoate metabolism_Homo sapiens_hsa006402.93081360
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75776907
12Linoleic acid metabolism_Homo sapiens_hsa005912.67505787
13Glucagon signaling pathway_Homo sapiens_hsa049222.59690302
14Retinol metabolism_Homo sapiens_hsa008302.46867916
15Selenocompound metabolism_Homo sapiens_hsa004502.46003628
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.39991648
17Basal transcription factors_Homo sapiens_hsa030222.26402138
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.23032781
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.14657503
20Carbohydrate digestion and absorption_Homo sapiens_hsa049732.06065212
21Caffeine metabolism_Homo sapiens_hsa002322.03408905
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01438164
23Glycerolipid metabolism_Homo sapiens_hsa005611.93713800
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91761746
25Fat digestion and absorption_Homo sapiens_hsa049751.82240661
26Carbon metabolism_Homo sapiens_hsa012001.80529530
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.77209075
28PPAR signaling pathway_Homo sapiens_hsa033201.69928351
29Oocyte meiosis_Homo sapiens_hsa041141.65773609
30Renin-angiotensin system_Homo sapiens_hsa046141.60728803
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.58262823
32Fanconi anemia pathway_Homo sapiens_hsa034601.56672124
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56095659
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.52727417
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.48055529
36Sphingolipid metabolism_Homo sapiens_hsa006001.47993597
37Fructose and mannose metabolism_Homo sapiens_hsa000511.43268294
38Fatty acid degradation_Homo sapiens_hsa000711.42677246
39Biosynthesis of amino acids_Homo sapiens_hsa012301.42538539
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.37984758
41Tight junction_Homo sapiens_hsa045301.33220915
42Huntingtons disease_Homo sapiens_hsa050161.31631015
43Cardiac muscle contraction_Homo sapiens_hsa042601.31258082
44Amphetamine addiction_Homo sapiens_hsa050311.29746437
45Fatty acid metabolism_Homo sapiens_hsa012121.24288900
46RNA transport_Homo sapiens_hsa030131.20395021
47Mineral absorption_Homo sapiens_hsa049781.19855243
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17180124
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15760625
50Glutathione metabolism_Homo sapiens_hsa004801.13302200
51Systemic lupus erythematosus_Homo sapiens_hsa053221.12786045
52Antigen processing and presentation_Homo sapiens_hsa046121.10016139
53mRNA surveillance pathway_Homo sapiens_hsa030151.09737740
54Purine metabolism_Homo sapiens_hsa002301.04939602
55Peroxisome_Homo sapiens_hsa041461.04834266
56Ether lipid metabolism_Homo sapiens_hsa005651.01291126
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89859792
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.87599306
59Dorso-ventral axis formation_Homo sapiens_hsa043200.87278522
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84545825
61Circadian rhythm_Homo sapiens_hsa047100.83317928
62Renin secretion_Homo sapiens_hsa049240.82095149
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79997172
64Starch and sucrose metabolism_Homo sapiens_hsa005000.77990539
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75073904
66Notch signaling pathway_Homo sapiens_hsa043300.74593755
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.74248751
68Estrogen signaling pathway_Homo sapiens_hsa049150.72737734
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70544233
70Bile secretion_Homo sapiens_hsa049760.70454904
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.69823758
72Thyroid hormone synthesis_Homo sapiens_hsa049180.68618336
73Legionellosis_Homo sapiens_hsa051340.68333276
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.67182600
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67133422
76Pancreatic secretion_Homo sapiens_hsa049720.66592139
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65842146
78Protein digestion and absorption_Homo sapiens_hsa049740.65222378
79Hepatitis C_Homo sapiens_hsa051600.65061375
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64728877
81Insulin secretion_Homo sapiens_hsa049110.64265305
82Sulfur metabolism_Homo sapiens_hsa009200.63795910
83AMPK signaling pathway_Homo sapiens_hsa041520.62811267
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62730557
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61897142
86Taste transduction_Homo sapiens_hsa047420.61593854
87Choline metabolism in cancer_Homo sapiens_hsa052310.60496944
88Collecting duct acid secretion_Homo sapiens_hsa049660.55337153
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55300285
90Arachidonic acid metabolism_Homo sapiens_hsa005900.54178484
91Adherens junction_Homo sapiens_hsa045200.53067053
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52525305
93Olfactory transduction_Homo sapiens_hsa047400.52145556
94Lysine degradation_Homo sapiens_hsa003100.51460281
95Alcoholism_Homo sapiens_hsa050340.49855098
96Endocytosis_Homo sapiens_hsa041440.47979122
97Long-term potentiation_Homo sapiens_hsa047200.46457683
98Chemical carcinogenesis_Homo sapiens_hsa052040.46140155
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45161192
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44153044
101Pyrimidine metabolism_Homo sapiens_hsa002400.43899338
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43371080
103ABC transporters_Homo sapiens_hsa020100.42936765
104Viral carcinogenesis_Homo sapiens_hsa052030.42493374
105Metabolic pathways_Homo sapiens_hsa011000.42018910
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.39421087
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38711229
108N-Glycan biosynthesis_Homo sapiens_hsa005100.37726182
109DNA replication_Homo sapiens_hsa030300.37567266
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36869970
111Arginine and proline metabolism_Homo sapiens_hsa003300.36708322
112Hematopoietic cell lineage_Homo sapiens_hsa046400.36283471
113VEGF signaling pathway_Homo sapiens_hsa043700.34674873
114Complement and coagulation cascades_Homo sapiens_hsa046100.34247811
115Amoebiasis_Homo sapiens_hsa051460.34071678
116Lysosome_Homo sapiens_hsa041420.32194168
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.32136370
118Calcium signaling pathway_Homo sapiens_hsa040200.31107684
119Inositol phosphate metabolism_Homo sapiens_hsa005620.30750317
120Cell cycle_Homo sapiens_hsa041100.30690642
121Hedgehog signaling pathway_Homo sapiens_hsa043400.30283001
122Insulin resistance_Homo sapiens_hsa049310.29467838
123Basal cell carcinoma_Homo sapiens_hsa052170.29454903
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28145900
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26246974
126RNA degradation_Homo sapiens_hsa030180.25248712
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24625152
128Type I diabetes mellitus_Homo sapiens_hsa049400.24606762
129Cocaine addiction_Homo sapiens_hsa050300.24273767
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23113869
131Vitamin digestion and absorption_Homo sapiens_hsa049770.19452334
132B cell receptor signaling pathway_Homo sapiens_hsa046620.19302661
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19089435
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19002701
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.18805236
136Salmonella infection_Homo sapiens_hsa051320.17763577
137Allograft rejection_Homo sapiens_hsa053300.17228851
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17056872
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17040664
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.16770581
141Autoimmune thyroid disease_Homo sapiens_hsa053200.15939534
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15404212
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14845632
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14468889
145Homologous recombination_Homo sapiens_hsa034400.14044129
146Arginine biosynthesis_Homo sapiens_hsa002200.13766226
147Salivary secretion_Homo sapiens_hsa049700.13584139
148Vibrio cholerae infection_Homo sapiens_hsa051100.12806914
149Jak-STAT signaling pathway_Homo sapiens_hsa046300.12529573
150cAMP signaling pathway_Homo sapiens_hsa040240.12516168
151Base excision repair_Homo sapiens_hsa034100.12229756
152Sulfur relay system_Homo sapiens_hsa041220.11733978
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.11665835
154Nicotine addiction_Homo sapiens_hsa050330.11351026
155Hippo signaling pathway_Homo sapiens_hsa043900.11330680
156Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11053306
157Graft-versus-host disease_Homo sapiens_hsa053320.10656645
158Phototransduction_Homo sapiens_hsa047440.10431640
159Serotonergic synapse_Homo sapiens_hsa047260.09655762
160Phagosome_Homo sapiens_hsa041450.09453885
161Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08457283
162Prostate cancer_Homo sapiens_hsa052150.07379847
163Dilated cardiomyopathy_Homo sapiens_hsa054140.06840651
164RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06755745
165Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.05947182

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