ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	9.52697420
2	chromosome condensation (GO:0030261)	9.17679565
3	DNA packaging (GO:0006323)	8.90640748
4	spermatid development (GO:0007286)	8.77314850
5	plasma membrane fusion (GO:0045026)	8.62829879
6	response to pheromone (GO:0019236)	8.27415424
7	single strand break repair (GO:0000012)	8.23904683
8	sperm-egg recognition (GO:0035036)	8.03729460
9	spermatid nucleus differentiation (GO:0007289)	8.02875332
10	microtubule depolymerization (GO:0007019)	7.78243849
11	multicellular organism reproduction (GO:0032504)	7.74598324
12	binding of sperm to zona pellucida (GO:0007339)	7.64229048
13	rRNA methylation (GO:0031167)	7.39857644
14	reproduction (GO:0000003)	7.26163298
15	phosphatidylethanolamine biosynthetic process (GO:0006646)	7.06310540
16	sexual reproduction (GO:0019953)	6.88297406
17	protein polyglutamylation (GO:0018095)	6.82794471
18	calcium ion-dependent exocytosis (GO:0017156)	6.77242388
19	negative regulation of inclusion body assembly (GO:0090084)	6.72164760
20	cell-cell recognition (GO:0009988)	6.62100028
21	protein targeting to Golgi (GO:0000042)	6.54420035
22	phosphatidylethanolamine metabolic process (GO:0046337)	6.54197409
23	rRNA modification (GO:0000154)	6.46054532
24	microtubule severing (GO:0051013)	6.30877657
25	microtubule polymerization or depolymerization (GO:0031109)	6.25091259
26	spermatogenesis (GO:0007283)	6.21830567
27	male gamete generation (GO:0048232)	6.19514206
28	establishment of protein localization to Golgi (GO:0072600)	6.16982766
29	axonemal dynein complex assembly (GO:0070286)	6.08569607
30	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.06673179
31	cellular ketone body metabolic process (GO:0046950)	5.69061885
32	gamete generation (GO:0007276)	5.65715298
33	regulation of cilium movement (GO:0003352)	5.40683424
34	single fertilization (GO:0007338)	5.33611023
35	motile cilium assembly (GO:0044458)	5.31023396
36	centriole replication (GO:0007099)	5.16667408
37	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.12401600
38	positive regulation of Rab GTPase activity (GO:0032851)	5.08268963
39	regulation of Rab GTPase activity (GO:0032313)	5.08268963
40	ketone body metabolic process (GO:1902224)	4.98634809
41	germ cell development (GO:0007281)	4.93916286
42	centriole assembly (GO:0098534)	4.91882474
43	regulation of inclusion body assembly (GO:0090083)	4.90227562
44	protein localization to Golgi apparatus (GO:0034067)	4.71733789
45	regulation of transcription involved in cell fate commitment (GO:0060850)	4.69290791
46	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.57508534
47	RNA destabilization (GO:0050779)	4.55180553
48	multicellular organismal reproductive process (GO:0048609)	4.54777826
49	polyamine biosynthetic process (GO:0006596)	4.48551140
50	cilium or flagellum-dependent cell motility (GO:0001539)	4.42920976
51	response to acidic pH (GO:0010447)	4.40422961
52	chromatin silencing (GO:0006342)	4.34313582
53	cell wall macromolecule catabolic process (GO:0016998)	4.31864618
54	coenzyme catabolic process (GO:0009109)	4.27729134
55	fertilization (GO:0009566)	4.26999528
56	cell wall macromolecule metabolic process (GO:0044036)	4.22401122
57	organic cation transport (GO:0015695)	4.10166338
58	nucleus organization (GO:0006997)	3.99467168
59	regulation of centriole replication (GO:0046599)	3.88097319
60	nucleosome disassembly (GO:0006337)	3.87202794
61	protein-DNA complex disassembly (GO:0032986)	3.87202794
62	regulation of T-helper 2 cell differentiation (GO:0045628)	3.86056481
63	epithelial cilium movement (GO:0003351)	3.84000020
64	regulation of microtubule-based movement (GO:0060632)	3.76718554
65	cellular response to pH (GO:0071467)	3.69420208
66	glycerol ether metabolic process (GO:0006662)	3.69376010
67	regulation of interleukin-13 production (GO:0032656)	3.61791360
68	seminiferous tubule development (GO:0072520)	3.57567018
69	membrane protein intracellular domain proteolysis (GO:0031293)	3.50372900
70	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.47831050
71	ether metabolic process (GO:0018904)	3.39789429
72	cilium movement (GO:0003341)	3.26494995
73	musculoskeletal movement (GO:0050881)	3.26383972
74	multicellular organismal movement (GO:0050879)	3.26383972
75	cerebral cortex neuron differentiation (GO:0021895)	3.22255978
76	peptidyl-threonine dephosphorylation (GO:0035970)	3.18507694
77	histone H3-K9 demethylation (GO:0033169)	3.09561718
78	negative regulation of Rho protein signal transduction (GO:0035024)	3.08942522
79	multicellular organismal development (GO:0007275)	3.03318381
80	regulation of ARF GTPase activity (GO:0032312)	3.03302103
81	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.02123517
82	cell recognition (GO:0008037)	3.01249439
83	male meiosis (GO:0007140)	3.00486550
84	protein depolymerization (GO:0051261)	2.97734229
85	microtubule nucleation (GO:0007020)	2.97182016
86	homeostasis of number of cells within a tissue (GO:0048873)	2.94563210
87	mitochondrial fission (GO:0000266)	2.93613072
88	cellular biogenic amine biosynthetic process (GO:0042401)	2.89675255
89	negative regulation of gene expression, epigenetic (GO:0045814)	2.88101482
90	cofactor catabolic process (GO:0051187)	2.86558245
91	mitotic G1 DNA damage checkpoint (GO:0031571)	2.86284182
92	positive regulation of type 2 immune response (GO:0002830)	2.81266999
93	amine biosynthetic process (GO:0009309)	2.78183781
94	receptor recycling (GO:0001881)	2.77456196
95	cranial nerve morphogenesis (GO:0021602)	2.77223728
96	piRNA metabolic process (GO:0034587)	2.75032227
97	NAD biosynthetic process (GO:0009435)	2.71709578
98	acrosome reaction (GO:0007340)	12.4566173
99	sperm motility (GO:0030317)	12.3998153
100	fusion of sperm to egg plasma membrane (GO:0007342)	11.4608591

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.78805800
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.20902305
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.88349763
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.73213581
5	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.70929743
6	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.47510038
7	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	2.31197290
8	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	2.27597250
9	ERA_21632823_ChIP-Seq_H3396_Human	2.26527337
10	RAC3_21632823_ChIP-Seq_H3396_Human	2.25401165
11	LXR_22292898_ChIP-Seq_THP-1_Human	2.23489596
12	CTCF_27219007_Chip-Seq_Bcells_Human	2.22235456
13	* BCL6_27268052_Chip-Seq_Bcells_Human	2.18615562
14	P68_20966046_ChIP-Seq_HELA_Human	2.15474540
15	SMC4_20622854_ChIP-Seq_HELA_Human	2.14667859
16	BCOR_27268052_Chip-Seq_Bcells_Human	2.13561848
17	NANOG_20526341_ChIP-Seq_ESCs_Human	2.08418277
18	E2F1_20622854_ChIP-Seq_HELA_Human	2.07768088
19	PHF8_20622854_ChIP-Seq_HELA_Human	2.03843005
20	CTCF_20526341_ChIP-Seq_ESCs_Human	2.02223014
21	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.99448007
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.95023157
23	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.94434422
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.91777852
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91777852
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84472600
27	TP63_22573176_ChIP-Seq_HFKS_Human	1.76630950
28	OCT4_20526341_ChIP-Seq_ESCs_Human	1.73767487
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.73587157
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.73587157
31	P300_27268052_Chip-Seq_Bcells_Human	1.72865328
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70664905
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.68669528
34	MYC_19829295_ChIP-Seq_ESCs_Human	1.67451275
35	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.67360415
36	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.67290927
37	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.65642263
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63694006
39	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.59862872
40	DROSHA_22980978_ChIP-Seq_HELA_Human	1.51104225
41	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.50843649
42	SA1_27219007_Chip-Seq_Bcells_Human	1.50268992
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49850411
44	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.47770810
45	ERG_20517297_ChIP-Seq_VCAP_Human	1.43764742
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40703064
47	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.37689369
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35479993
49	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.34308100
50	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.34096050
51	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.30578109
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.30016299
53	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.29949893
54	CTCF_21964334_Chip-Seq_Bcells_Human	1.27272930
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26146601
56	EZH2_22144423_ChIP-Seq_EOC_Human	1.25276100
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25106311
58	RBPJ_21746931_ChIP-Seq_IB4_Human	1.22498004
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21770983
60	P53_21459846_ChIP-Seq_SAOS-2_Human	1.21207548
61	CEBPB_22108803_ChIP-Seq_LS180_Human	1.21177547
62	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20344852
63	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.19826178
64	OCT4_19829295_ChIP-Seq_ESCs_Human	1.19670573
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17938332
66	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.17671137
67	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.17162886
68	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.17099780
69	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.16973806
70	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.16726579
71	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.16019164
72	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.14519011
73	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.13866852
74	FUS_26573619_Chip-Seq_HEK293_Human	1.12969669
75	* SPI1_20517297_ChIP-Seq_HL60_Human	1.12873238
76	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.11692587
77	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.11220251
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10064493
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09737946
80	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.09141300
81	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.08427303
82	* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.07685654
83	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.07478821
84	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04438932
85	ETV1_20927104_ChIP-Seq_GIST48_Human	1.03673523
86	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.03263746
87	SOX2_21211035_ChIP-Seq_LN229_Human	1.03142247
88	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.02392151
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.01309906
90	STAT1_20625510_ChIP-Seq_HELA_Human	1.00828195
91	RUNX_20019798_ChIP-Seq_JUKART_Human	1.00073510
92	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.98045053
93	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.97980610
94	SMRT_27268052_Chip-Seq_Bcells_Human	0.97927410
95	AR_25329375_ChIP-Seq_VCAP_Human	0.97730303
96	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.97596102
97	KLF4_19829295_ChIP-Seq_ESCs_Human	0.96401229
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96349301
99	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.95178635
100	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.95070634

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	4.84693126
2	MP0005377_hearing/vestibular/ear_phenot	4.84693126
3	MP0003698_abnormal_male_reproductive	4.43470022
4	MP0005670_abnormal_white_adipose	4.27678419
5	MP0001929_abnormal_gametogenesis	3.89716784
6	MP0001348_abnormal_lacrimal_gland	3.29440098
7	MP0000678_abnormal_parathyroid_gland	2.78032565
8	MP0002161_abnormal_fertility/fecundity	2.51881209
9	MP0002132_abnormal_respiratory_system	2.49728300
10	MP0005451_abnormal_body_composition	2.44370912
11	MP0003718_maternal_effect	2.16545165
12	MP0005410_abnormal_fertilization	12.4224433
13	MP0002210_abnormal_sex_determination	1.80380954
14	MP0003011_delayed_dark_adaptation	1.71847147
15	MP0005379_endocrine/exocrine_gland_phen	1.71057383
16	MP0003646_muscle_fatigue	1.70932180
17	MP0002822_catalepsy	1.70403512
18	MP0005310_abnormal_salivary_gland	1.65435246
19	MP0005423_abnormal_somatic_nervous	1.55800686
20	MP0004510_myositis	1.55326976
21	MP0001145_abnormal_male_reproductive	1.47282244
22	MP0002249_abnormal_larynx_morphology	1.43036141
23	MP0003879_abnormal_hair_cell	1.42889970
24	MP0000653_abnormal_sex_gland	1.36051278
25	MP0002234_abnormal_pharynx_morphology	1.31961477
26	MP0001486_abnormal_startle_reflex	1.29929555
27	MP0001905_abnormal_dopamine_level	1.26027753
28	MP0004859_abnormal_synaptic_plasticity	1.24412108
29	MP0001968_abnormal_touch/_nociception	1.21869800
30	MP0001765_abnormal_ion_homeostasis	1.16951651
31	MP0001485_abnormal_pinna_reflex	1.13881249
32	MP0009053_abnormal_anal_canal	1.11572008
33	MP0002735_abnormal_chemical_nociception	1.11495014
34	MP0002138_abnormal_hepatobiliary_system	1.09644443
35	MP0004742_abnormal_vestibular_system	1.07280809
36	MP0002282_abnormal_trachea_morphology	0.99679689
37	MP0001963_abnormal_hearing_physiology	0.93018155
38	MP0002229_neurodegeneration	0.91753881
39	MP0005395_other_phenotype	0.91583970
40	MP0002127_abnormal_cardiovascular_syste	0.91360326
41	MP0005248_abnormal_Harderian_gland	0.87689918
42	MP0000681_abnormal_thyroid_gland	0.83162928
43	MP0000534_abnormal_ureter_morphology	0.82437813
44	MP0000026_abnormal_inner_ear	0.79607215
45	MP0008877_abnormal_DNA_methylation	0.76673892
46	MP0005083_abnormal_biliary_tract	0.76438785
47	MP0005636_abnormal_mineral_homeostasis	0.74434298
48	MP0002067_abnormal_sensory_capabilities	0.70919963
49	MP0009115_abnormal_fat_cell	0.69768628
50	MP0003172_abnormal_lysosome_physiology	0.69300738
51	MP0005666_abnormal_adipose_tissue	0.67504608
52	MP0000955_abnormal_spinal_cord	0.67005834
53	MP0009697_abnormal_copulation	0.62819986
54	MP0008569_lethality_at_weaning	0.61772631
55	MP0004233_abnormal_muscle_weight	0.61733916
56	MP0005367_renal/urinary_system_phenotyp	0.61393014
57	MP0000516_abnormal_urinary_system	0.61393014
58	MP0002557_abnormal_social/conspecific_i	0.60971279
59	MP0002733_abnormal_thermal_nociception	0.60487303
60	MP0008004_abnormal_stomach_pH	0.59941883
61	MP0005535_abnormal_body_temperature	0.56540858
62	MP0003077_abnormal_cell_cycle	0.56055602
63	MP0005551_abnormal_eye_electrophysiolog	0.55763726
64	MP0000470_abnormal_stomach_morphology	0.55558937
65	MP0004085_abnormal_heartbeat	0.55094776
66	MP0002572_abnormal_emotion/affect_behav	0.54765531
67	MP0001666_abnormal_nutrient_absorption	0.53354385
68	MP0005647_abnormal_sex_gland	0.53072349
69	MP0001873_stomach_inflammation	0.52375943
70	MP0005375_adipose_tissue_phenotype	0.51760084
71	MP0008995_early_reproductive_senescence	0.51637576
72	MP0005166_decreased_susceptibility_to	0.51285744
73	MP0001970_abnormal_pain_threshold	0.50498807
74	MP0009745_abnormal_behavioral_response	0.50077257
75	MP0002653_abnormal_ependyma_morphology	0.50039470
76	MP0009764_decreased_sensitivity_to	0.49227318
77	MP0006036_abnormal_mitochondrial_physio	0.47672004
78	MP0008874_decreased_physiological_sensi	0.46843783
79	MP0002272_abnormal_nervous_system	0.45874047
80	MP0001984_abnormal_olfaction	0.45757133
81	MP0000049_abnormal_middle_ear	0.45454292
82	MP0001501_abnormal_sleep_pattern	0.42357755
83	MP0001835_abnormal_antigen_presentation	0.41565422
84	MP0002254_reproductive_system_inflammat	0.40869860
85	MP0002693_abnormal_pancreas_physiology	0.39832668
86	MP0003699_abnormal_female_reproductive	0.39512665
87	MP0001440_abnormal_grooming_behavior	0.39495187
88	MP0003137_abnormal_impulse_conducting	0.39148220
89	MP0002734_abnormal_mechanical_nocicepti	0.39117145
90	MP0005167_abnormal_blood-brain_barrier	0.38025803
91	MP0003806_abnormal_nucleotide_metabolis	0.36863876
92	MP0005253_abnormal_eye_physiology	0.36424500
93	MP0009785_altered_susceptibility_to	0.36251537
94	MP0000003_abnormal_adipose_tissue	0.35992841
95	MP0001529_abnormal_vocalization	0.35842775
96	MP0005332_abnormal_amino_acid	0.35665758
97	MP0003936_abnormal_reproductive_system	0.35184999
98	MP0001764_abnormal_homeostasis	0.34630055
99	MP0010386_abnormal_urinary_bladder	0.34543060
100	MP0003631_nervous_system_phenotype	0.33473216

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.54762081
2	Absent/shortened dynein arms (HP:0200106)	5.96285989
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.96285989
4	Resting tremor (HP:0002322)	5.65647622
5	Asymmetric septal hypertrophy (HP:0001670)	5.25758142
6	Bony spicule pigmentary retinopathy (HP:0007737)	5.05443303
7	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.87921020
8	Attenuation of retinal blood vessels (HP:0007843)	4.77412940
9	Nasal polyposis (HP:0100582)	4.56373821
10	Abnormal ciliary motility (HP:0012262)	4.55518149
11	Infertility (HP:0000789)	4.54824836
12	Abnormal respiratory motile cilium physiology (HP:0012261)	4.42403112
13	Male infertility (HP:0003251)	4.34258966
14	Tubulointerstitial nephritis (HP:0001970)	4.19695238
15	Abnormal respiratory motile cilium morphology (HP:0005938)	4.19459262
16	Abnormal respiratory epithelium morphology (HP:0012253)	4.19459262
17	Abnormal rod and cone electroretinograms (HP:0008323)	4.18818690
18	Chronic hepatic failure (HP:0100626)	3.99994468
19	Enlarged epiphyses (HP:0010580)	3.87310638
20	Bell-shaped thorax (HP:0001591)	3.86935917
21	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.80292825
22	Abnormality of the nasal mucosa (HP:0000433)	3.65563640
23	Hyperkalemia (HP:0002153)	3.65441746
24	Abnormality of macular pigmentation (HP:0008002)	3.62217094
25	Hypoplasia of the thymus (HP:0000778)	3.61407516
26	Generalized aminoaciduria (HP:0002909)	3.51553782
27	Facial shape deformation (HP:0011334)	3.46728704
28	Potter facies (HP:0002009)	3.46728704
29	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.42360737
30	Postural instability (HP:0002172)	3.41174594
31	Abnormal spermatogenesis (HP:0008669)	3.31926911
32	Cone-rod dystrophy (HP:0000548)	3.20847643
33	Azoospermia (HP:0000027)	3.18885795
34	Impulsivity (HP:0100710)	3.13599779
35	Progressive sensorineural hearing impairment (HP:0000408)	3.06487664
36	Unilateral renal agenesis (HP:0000122)	3.02647662
37	Hypoplastic ischia (HP:0003175)	3.01768103
38	Abnormality of the costochondral junction (HP:0000919)	2.98104284
39	Abnormality of dental color (HP:0011073)	2.93501695
40	Amelogenesis imperfecta (HP:0000705)	2.91641419
41	Congenital malformation of the right heart (HP:0011723)	2.74098025
42	Double outlet right ventricle (HP:0001719)	2.74098025
43	Renal Fanconi syndrome (HP:0001994)	2.72467542
44	Abnormality of the aortic arch (HP:0012303)	2.67483334
45	Hypoalphalipoproteinemia (HP:0003233)	2.65454921
46	Abnormal urine output (HP:0012590)	2.58105822
47	Rhinitis (HP:0012384)	2.52974704
48	Insulin-resistant diabetes mellitus (HP:0000831)	2.52527715
49	Renal dysplasia (HP:0000110)	2.52034937
50	Abnormality of the ischium (HP:0003174)	2.49583850
51	Menstrual irregularities (HP:0000858)	2.45098930
52	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.44578968
53	Widely patent fontanelles and sutures (HP:0004492)	2.43612082
54	Myokymia (HP:0002411)	2.41108038
55	Progressive cerebellar ataxia (HP:0002073)	2.38718760
56	Hyperthyroidism (HP:0000836)	2.32246150
57	Spastic paraparesis (HP:0002313)	2.30072307
58	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.29673130
59	Abnormality of renal excretion (HP:0011036)	2.25190777
60	Flattened epiphyses (HP:0003071)	2.19507906
61	Truncal obesity (HP:0001956)	2.14587950
62	Tetany (HP:0001281)	2.14401647
63	Upper limb muscle weakness (HP:0003484)	2.13981682
64	Stage 5 chronic kidney disease (HP:0003774)	2.11958756
65	Sensory axonal neuropathy (HP:0003390)	2.10898800
66	Hypoparathyroidism (HP:0000829)	2.09797253
67	Hypophosphatemic rickets (HP:0004912)	2.08487613
68	Abnormality of potassium homeostasis (HP:0011042)	2.07735930
69	Hyponatremia (HP:0002902)	2.06906210
70	Progressive hearing impairment (HP:0001730)	2.06219860
71	Increased purine levels (HP:0004368)	2.05185278
72	Hyperuricemia (HP:0002149)	2.05185278
73	Epiphyseal dysplasia (HP:0002656)	2.00929236
74	Recurrent pneumonia (HP:0006532)	2.00308081
75	Ventricular tachycardia (HP:0004756)	1.99778307
76	Abnormal drinking behavior (HP:0030082)	1.99737972
77	Polydipsia (HP:0001959)	1.99737972
78	Polyuria (HP:0000103)	1.99271211
79	Nephronophthisis (HP:0000090)	1.97527712
80	Renovascular hypertension (HP:0100817)	1.97488783
81	Abnormality of urine glucose concentration (HP:0011016)	1.97213699
82	Glycosuria (HP:0003076)	1.97213699
83	Bronchiectasis (HP:0002110)	1.92166751
84	Abnormality of renal resorption (HP:0011038)	1.91126021
85	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.87370937
86	Portal hypertension (HP:0001409)	1.86632357
87	Recurrent corneal erosions (HP:0000495)	1.85557350
88	Peripheral hypomyelination (HP:0007182)	1.85019956
89	Absent epiphyses (HP:0010577)	1.84573256
90	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.84573256
91	Abnormality of the parathyroid morphology (HP:0011766)	1.84128051
92	Chronic bronchitis (HP:0004469)	1.83644391
93	Bowel incontinence (HP:0002607)	1.80616569
94	Abnormality of the hepatic vasculature (HP:0006707)	1.77333340
95	Failure to thrive in infancy (HP:0001531)	1.76365759
96	Prolonged neonatal jaundice (HP:0006579)	1.75784134
97	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.75475580
98	Abnormal large intestine physiology (HP:0012700)	1.73840565
99	Truncus arteriosus (HP:0001660)	1.72008900
100	Seborrheic dermatitis (HP:0001051)	1.71072728

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.76908584
2	TESK1	7.37220873
3	DDR2	4.55219067
4	STK38	3.75402486
5	MAP4K2	3.61705883
6	INSRR	3.13436362
7	PRKD3	2.55480501
8	PLK2	2.40263724
9	BRD4	2.27898134
10	MAPK15	2.15128189
11	MST1R	2.09215736
12	PNCK	2.07292632
13	STK38L	2.01102081
14	PDPK1	1.89986620
15	PINK1	1.82700302
16	PDK1	1.66962221
17	CAMK1G	1.61038515
18	ARAF	1.48046066
19	MAP3K9	1.45934308
20	TESK2	1.41267670
21	CDK7	1.33949859
22	MAP3K11	1.26533812
23	DYRK1B	1.23960486
24	KSR2	1.18378288
25	RIPK4	1.18267275
26	PIK3CG	1.18067820
27	NEK6	1.10928188
28	BRAF	1.06572993
29	PRKG2	1.02684229
30	CDK12	0.98840121
31	PTK2B	0.97963898
32	WNK1	0.96778488
33	SIK2	0.78095385
34	LATS2	0.77486765
35	MAP3K1	0.76774023
36	RPS6KA2	0.74660150
37	TLK1	0.73304353
38	MAP3K8	0.70843804
39	MAP3K2	0.70566347
40	NME2	0.68395826
41	MAP2K2	0.67132261
42	RPS6KA1	0.66405867
43	MARK3	0.65272634
44	CDK3	0.59707871
45	MUSK	0.59684073
46	PRKG1	0.58136269
47	MYLK	0.50742884
48	DYRK3	0.49706479
49	GRK6	0.49638473
50	ROCK1	0.46065291
51	UHMK1	0.43621674
52	LATS1	0.42761360
53	CAMK1	0.40957724
54	MAP2K7	0.39460236
55	CDK4	0.37977952
56	GSK3B	0.35019696
57	IKBKB	0.33602458
58	PRKCZ	0.32941781
59	RPS6KC1	0.32735539
60	RPS6KL1	0.32735539
61	MAP3K13	0.32644571
62	TYRO3	0.32373111
63	CDK2	0.32372223
64	CAMK1D	0.31740353
65	ZAK	0.31018687
66	MAPK8	0.30590916
67	CDK1	0.30336825
68	MAPK1	0.30047805
69	BLK	0.29535550
70	MAP3K12	0.29248172
71	DYRK2	0.27547777
72	MAPK11	0.26869514
73	PRKAA2	0.26651262
74	ABL2	0.26420717
75	BRSK1	0.26355770
76	MTOR	0.25978627
77	TNK2	0.25676617
78	MINK1	0.25576815
79	RPS6KA6	0.24829959
80	PAK1	0.24235371
81	JAK3	0.23997299
82	AURKA	0.23544272
83	RPS6KA5	0.23250634
84	SGK494	0.21936787
85	SGK223	0.21936787
86	MARK2	0.21892558
87	CSNK1G3	0.21772648
88	PRKCG	0.21429977
89	CAMK4	0.20697005
90	TRIB3	0.19815064
91	NEK2	0.19188062
92	MAP4K1	0.18320986
93	CHEK1	0.17111504
94	MAP3K3	0.17087167
95	GRK7	0.15166970
96	PRKCB	0.14578454
97	PRKCQ	0.14374585
98	CDK14	0.13502794
99	CDK19	0.12863479
100	WNK4	0.12691820

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.71737398
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.30573647
3	Olfactory transduction_Homo sapiens_hsa04740	3.72886895
4	Allograft rejection_Homo sapiens_hsa05330	2.40001256
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.39005218
6	Butanoate metabolism_Homo sapiens_hsa00650	2.36653632
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.29665288
8	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.29600957
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.15881699
10	Phenylalanine metabolism_Homo sapiens_hsa00360	2.00280343
11	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.97634161
12	Antigen processing and presentation_Homo sapiens_hsa04612	1.80402449
13	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.75622281
14	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.66848580
15	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.64074830
16	Viral myocarditis_Homo sapiens_hsa05416	1.56360265
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.55090932
18	RNA transport_Homo sapiens_hsa03013	1.53050292
19	Type II diabetes mellitus_Homo sapiens_hsa04930	1.48287809
20	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.46602261
21	Fatty acid degradation_Homo sapiens_hsa00071	1.44965949
22	Endocytosis_Homo sapiens_hsa04144	1.44046536
23	Taste transduction_Homo sapiens_hsa04742	1.40948398
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.39013564
25	Sulfur relay system_Homo sapiens_hsa04122	1.33539207
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.23726877
27	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.19673095
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.10704187
29	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.04877405
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02583950
31	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.00764064
32	Tyrosine metabolism_Homo sapiens_hsa00350	0.95534208
33	Huntingtons disease_Homo sapiens_hsa05016	0.89133685
34	Influenza A_Homo sapiens_hsa05164	0.87812830
35	Phototransduction_Homo sapiens_hsa04744	0.86399943
36	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.84639885
37	PPAR signaling pathway_Homo sapiens_hsa03320	0.83694517
38	Oocyte meiosis_Homo sapiens_hsa04114	0.83623083
39	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.77558469
40	Purine metabolism_Homo sapiens_hsa00230	0.73714926
41	Selenocompound metabolism_Homo sapiens_hsa00450	0.72792823
42	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.72408111
43	Acute myeloid leukemia_Homo sapiens_hsa05221	0.69143680
44	Phagosome_Homo sapiens_hsa04145	0.68614783
45	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64029043
46	Salivary secretion_Homo sapiens_hsa04970	0.63972287
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63372597
48	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.62178551
49	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.61286800
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.60785078
51	VEGF signaling pathway_Homo sapiens_hsa04370	0.59526057
52	Morphine addiction_Homo sapiens_hsa05032	0.56126595
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55027606
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51921654
55	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.51426896
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.50600692
57	Circadian entrainment_Homo sapiens_hsa04713	0.49849294
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.48882148
59	Estrogen signaling pathway_Homo sapiens_hsa04915	0.45413629
60	Regulation of autophagy_Homo sapiens_hsa04140	0.45017068
61	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.42173572
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.41765549
63	Metabolic pathways_Homo sapiens_hsa01100	0.41555785
64	Herpes simplex infection_Homo sapiens_hsa05168	0.39072187
65	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38788020
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38663154
67	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.35434820
68	cAMP signaling pathway_Homo sapiens_hsa04024	0.35410083
69	Legionellosis_Homo sapiens_hsa05134	0.34262677
70	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.33494046
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33214252
72	Nicotine addiction_Homo sapiens_hsa05033	0.33159275
73	Gastric acid secretion_Homo sapiens_hsa04971	0.33074551
74	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.33068699
75	Renin-angiotensin system_Homo sapiens_hsa04614	0.30922048
76	Basal transcription factors_Homo sapiens_hsa03022	0.30829441
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30750849
78	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.30375459
79	MAPK signaling pathway_Homo sapiens_hsa04010	0.29360185
80	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.29069962
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.28344698
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28337132
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.27363921
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.26883344
85	ABC transporters_Homo sapiens_hsa02010	0.26813871
86	Viral carcinogenesis_Homo sapiens_hsa05203	0.24353375
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24044820
88	Gap junction_Homo sapiens_hsa04540	0.23367393
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.22578381
90	Alcoholism_Homo sapiens_hsa05034	0.22078498
91	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.21436481
92	Toxoplasmosis_Homo sapiens_hsa05145	0.21210098
93	Base excision repair_Homo sapiens_hsa03410	0.20934870
94	Peroxisome_Homo sapiens_hsa04146	0.19928844
95	Carbon metabolism_Homo sapiens_hsa01200	0.19676484
96	Oxidative phosphorylation_Homo sapiens_hsa00190	0.19575328
97	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.18803928
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.17945632
99	Retinol metabolism_Homo sapiens_hsa00830	0.17763498
100	GABAergic synapse_Homo sapiens_hsa04727	0.16215400

TMEM191A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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