ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	9.61764361
2	plasma membrane fusion (GO:0045026)	9.58136596
3	chromosome condensation (GO:0030261)	9.31899068
4	response to pheromone (GO:0019236)	9.27657671
5	microtubule depolymerization (GO:0007019)	9.27017106
6	DNA packaging (GO:0006323)	8.83207531
7	spermatid development (GO:0007286)	8.71190544
8	sperm-egg recognition (GO:0035036)	8.31901003
9	single strand break repair (GO:0000012)	8.13197394
10	spermatid nucleus differentiation (GO:0007289)	8.07523531
11	binding of sperm to zona pellucida (GO:0007339)	7.97497920
12	multicellular organism reproduction (GO:0032504)	7.94859102
13	negative regulation of inclusion body assembly (GO:0090084)	7.82930003
14	reproduction (GO:0000003)	7.38776339
15	calcium ion-dependent exocytosis (GO:0017156)	7.11010912
16	sexual reproduction (GO:0019953)	6.87742523
17	cell-cell recognition (GO:0009988)	6.86254098
18	cellular ketone body metabolic process (GO:0046950)	6.84949236
19	microtubule polymerization or depolymerization (GO:0031109)	6.84919539
20	rRNA methylation (GO:0031167)	6.82313287
21	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.43032991
22	protein polyglutamylation (GO:0018095)	6.42244593
23	spermatogenesis (GO:0007283)	6.11626194
24	male gamete generation (GO:0048232)	6.09287504
25	microtubule severing (GO:0051013)	6.07845003
26	ketone body metabolic process (GO:1902224)	6.03265947
27	phosphatidylethanolamine metabolic process (GO:0046337)	5.95220026
28	axonemal dynein complex assembly (GO:0070286)	5.93616981
29	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.89907614
30	rRNA modification (GO:0000154)	5.80840066
31	regulation of inclusion body assembly (GO:0090083)	5.56846046
32	gamete generation (GO:0007276)	5.56135620
33	protein targeting to Golgi (GO:0000042)	5.20007019
34	single fertilization (GO:0007338)	5.19527810
35	regulation of cilium movement (GO:0003352)	5.06055907
36	establishment of protein localization to Golgi (GO:0072600)	4.96819414
37	regulation of Rab GTPase activity (GO:0032313)	4.93815341
38	positive regulation of Rab GTPase activity (GO:0032851)	4.93815341
39	motile cilium assembly (GO:0044458)	4.84259362
40	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.82901712
41	germ cell development (GO:0007281)	4.74706421
42	coenzyme catabolic process (GO:0009109)	4.70149763
43	regulation of transcription involved in cell fate commitment (GO:0060850)	4.58570309
44	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.49000260
45	multicellular organismal reproductive process (GO:0048609)	4.46531774
46	chromatin silencing (GO:0006342)	4.41897700
47	RNA destabilization (GO:0050779)	4.20349837
48	cilium or flagellum-dependent cell motility (GO:0001539)	4.13313978
49	centriole replication (GO:0007099)	4.11789838
50	response to acidic pH (GO:0010447)	4.08166130
51	cell wall macromolecule catabolic process (GO:0016998)	4.06020085
52	fertilization (GO:0009566)	3.99893958
53	centriole assembly (GO:0098534)	3.90947471
54	polyamine biosynthetic process (GO:0006596)	3.84502786
55	glycerol ether metabolic process (GO:0006662)	3.83155553
56	membrane protein intracellular domain proteolysis (GO:0031293)	3.78365536
57	peptidyl-threonine dephosphorylation (GO:0035970)	3.77295933
58	nucleus organization (GO:0006997)	3.76861481
59	protein localization to Golgi apparatus (GO:0034067)	3.76766368
60	epithelial cilium movement (GO:0003351)	3.75124739
61	organic cation transport (GO:0015695)	3.73828081
62	negative regulation of Rho protein signal transduction (GO:0035024)	3.70075658
63	cellular response to pH (GO:0071467)	3.67419896
64	cell wall macromolecule metabolic process (GO:0044036)	3.65603942
65	ether metabolic process (GO:0018904)	3.52604126
66	protein depolymerization (GO:0051261)	3.52590352
67	protein-DNA complex disassembly (GO:0032986)	3.52212287
68	nucleosome disassembly (GO:0006337)	3.52212287
69	regulation of microtubule-based movement (GO:0060632)	3.38239785
70	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.35447845
71	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.35447845
72	cilium movement (GO:0003341)	3.29069503
73	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.28733118
74	cell recognition (GO:0008037)	3.25874944
75	cerebral cortex neuron differentiation (GO:0021895)	3.24763909
76	NAD biosynthetic process (GO:0009435)	3.20818613
77	cell differentiation involved in metanephros development (GO:0072202)	3.15884339
78	histone H3-K9 demethylation (GO:0033169)	3.14945034
79	regulation of T-helper 2 cell differentiation (GO:0045628)	3.09998898
80	regulation of interleukin-13 production (GO:0032656)	3.09250347
81	cranial nerve morphogenesis (GO:0021602)	3.05597182
82	regulation of centriole replication (GO:0046599)	3.05536874
83	seminiferous tubule development (GO:0072520)	3.00641991
84	musculoskeletal movement (GO:0050881)	3.00362004
85	multicellular organismal movement (GO:0050879)	3.00362004
86	negative regulation of gene expression, epigenetic (GO:0045814)	2.99785151
87	multicellular organismal development (GO:0007275)	2.99516355
88	cofactor catabolic process (GO:0051187)	2.97469721
89	actin filament capping (GO:0051693)	2.94167199
90	glomerular visceral epithelial cell development (GO:0072015)	2.90289033
91	peptidyl-proline hydroxylation (GO:0019511)	2.89092571
92	homeostasis of number of cells within a tissue (GO:0048873)	2.86637797
93	glomerular epithelial cell development (GO:0072310)	2.84944754
94	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.84606178
95	regulation of ARF GTPase activity (GO:0032312)	2.76629999
96	chaperone-mediated protein complex assembly (GO:0051131)	2.75391743
97	opsonization (GO:0008228)	2.74380339
98	acrosome reaction (GO:0007340)	13.1857018
99	fusion of sperm to egg plasma membrane (GO:0007342)	12.6273895
100	sperm motility (GO:0030317)	11.8054136

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.93778434
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	4.21037658
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.43402964
4	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.42669670
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.35474557
6	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35474557
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.31051285
8	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.14195478
9	CTCF_27219007_Chip-Seq_Bcells_Human	2.08217803
10	ERA_21632823_ChIP-Seq_H3396_Human	2.07313890
11	RAC3_21632823_ChIP-Seq_H3396_Human	2.04873480
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04374424
13	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	2.03604713
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.02906270
15	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.99494139
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.96712860
17	E2F1_20622854_ChIP-Seq_HELA_Human	1.96443107
18	BCL6_27268052_Chip-Seq_Bcells_Human	1.94856260
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.94848031
20	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.94576944
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.94576944
22	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.89056088
23	LXR_22292898_ChIP-Seq_THP-1_Human	1.85365195
24	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.84733407
25	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.82838564
26	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.79929157
27	BCOR_27268052_Chip-Seq_Bcells_Human	1.79188578
28	SMC4_20622854_ChIP-Seq_HELA_Human	1.79003859
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75148848
30	P68_20966046_ChIP-Seq_HELA_Human	1.74522199
31	PHF8_20622854_ChIP-Seq_HELA_Human	1.73254989
32	DROSHA_22980978_ChIP-Seq_HELA_Human	1.71520701
33	CTCF_20526341_ChIP-Seq_ESCs_Human	1.71027280
34	MYC_19829295_ChIP-Seq_ESCs_Human	1.68209171
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66918666
36	TAF2_19829295_ChIP-Seq_ESCs_Human	1.66744808
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65518423
38	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.65089335
39	TP63_22573176_ChIP-Seq_HFKS_Human	1.62663706
40	OCT4_20526341_ChIP-Seq_ESCs_Human	1.60388163
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.56481404
42	FUS_26573619_Chip-Seq_HEK293_Human	1.53476805
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52235216
44	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.49479236
45	P300_27268052_Chip-Seq_Bcells_Human	1.48525794
46	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.46700531
47	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.43546443
48	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.42013856
49	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.41347148
50	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.41285543
51	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.40712076
52	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.38494737
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35653108
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33432437
55	TP53_18474530_ChIP-ChIP_U2OS_Human	1.32843239
56	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.29412653
57	RUNX_20019798_ChIP-Seq_JUKART_Human	1.28347435
58	ER_23166858_ChIP-Seq_MCF-7_Human	1.27917981
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25655658
60	ERG_20517297_ChIP-Seq_VCAP_Human	1.25050691
61	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.25021683
62	P53_21459846_ChIP-Seq_SAOS-2_Human	1.24299008
63	AR_25329375_ChIP-Seq_VCAP_Human	1.23923964
64	SA1_27219007_Chip-Seq_Bcells_Human	1.22726735
65	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.22551870
66	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.22059813
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21183021
68	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.20606619
69	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.19622319
70	RBPJ_21746931_ChIP-Seq_IB4_Human	1.18565974
71	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.17900727
72	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.17819588
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17805744
74	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.17248856
75	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.13126229
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12477384
77	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09912406
78	TAF15_26573619_Chip-Seq_HEK293_Human	1.09607149
79	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.08586979
80	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.08473085
81	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08193971
82	CEBPB_22108803_ChIP-Seq_LS180_Human	1.04985817
83	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.04838752
84	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.03797008
85	CTCF_21964334_Chip-Seq_Bcells_Human	1.02939577
86	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.01926468
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01857282
88	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.01074152
89	NFYB_21822215_ChIP-Seq_K562_Human	1.00478440
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.00123752
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99684398
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99684398
93	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.99291808
94	OCT4_19829295_ChIP-Seq_ESCs_Human	0.99159084
95	SMRT_27268052_Chip-Seq_Bcells_Human	0.98928390
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98530131
97	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.97915064
98	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97391302
99	TBL1_22424771_ChIP-Seq_293T_Human	0.97247377
100	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.96723074

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	4.60407271
2	MP0005377_hearing/vestibular/ear_phenot	4.57916488
3	MP0003878_abnormal_ear_physiology	4.57916488
4	MP0005670_abnormal_white_adipose	4.37920522
5	MP0001929_abnormal_gametogenesis	3.99492961
6	MP0003011_delayed_dark_adaptation	2.99148643
7	MP0001348_abnormal_lacrimal_gland	2.92329436
8	MP0000678_abnormal_parathyroid_gland	2.63951836
9	MP0002161_abnormal_fertility/fecundity	2.60087527
10	MP0002132_abnormal_respiratory_system	2.17981741
11	MP0003718_maternal_effect	2.17668464
12	MP0004510_myositis	2.01241175
13	MP0005410_abnormal_fertilization	12.8221355
14	MP0003646_muscle_fatigue	1.89364720
15	MP0005423_abnormal_somatic_nervous	1.76694086
16	MP0002210_abnormal_sex_determination	1.75091288
17	MP0002234_abnormal_pharynx_morphology	1.63062788
18	MP0002249_abnormal_larynx_morphology	1.50868601
19	MP0001145_abnormal_male_reproductive	1.47289350
20	MP0001968_abnormal_touch/_nociception	1.43721254
21	MP0001486_abnormal_startle_reflex	1.41849429
22	MP0004859_abnormal_synaptic_plasticity	1.40289049
23	MP0000653_abnormal_sex_gland	1.37686620
24	MP0001765_abnormal_ion_homeostasis	1.36835263
25	MP0005310_abnormal_salivary_gland	1.33981933
26	MP0002735_abnormal_chemical_nociception	1.33964027
27	MP0009053_abnormal_anal_canal	1.31210412
28	MP0002282_abnormal_trachea_morphology	1.30535634
29	MP0005379_endocrine/exocrine_gland_phen	1.21071453
30	MP0000534_abnormal_ureter_morphology	1.15614193
31	MP0004742_abnormal_vestibular_system	1.14388484
32	MP0002138_abnormal_hepatobiliary_system	1.11937618
33	MP0001485_abnormal_pinna_reflex	1.11689529
34	MP0002822_catalepsy	1.06569370
35	MP0001963_abnormal_hearing_physiology	1.03019321
36	MP0003879_abnormal_hair_cell	1.01008594
37	MP0000026_abnormal_inner_ear	0.97761819
38	MP0002127_abnormal_cardiovascular_syste	0.97000078
39	MP0002229_neurodegeneration	0.93277275
40	MP0005248_abnormal_Harderian_gland	0.92145892
41	MP0005395_other_phenotype	0.91814157
42	MP0005083_abnormal_biliary_tract	0.89647478
43	MP0000681_abnormal_thyroid_gland	0.87125754
44	MP0008569_lethality_at_weaning	0.86505273
45	MP0002733_abnormal_thermal_nociception	0.85397817
46	MP0000049_abnormal_middle_ear	0.83529566
47	MP0001905_abnormal_dopamine_level	0.83486456
48	MP0000516_abnormal_urinary_system	0.83222204
49	MP0005367_renal/urinary_system_phenotyp	0.83222204
50	MP0000955_abnormal_spinal_cord	0.82579463
51	MP0005636_abnormal_mineral_homeostasis	0.82068796
52	MP0005451_abnormal_body_composition	0.77483418
53	MP0002067_abnormal_sensory_capabilities	0.75485356
54	MP0005551_abnormal_eye_electrophysiolog	0.74049975
55	MP0004085_abnormal_heartbeat	0.73133231
56	MP0002653_abnormal_ependyma_morphology	0.72662096
57	MP0008995_early_reproductive_senescence	0.72517441
58	MP0008877_abnormal_DNA_methylation	0.66319835
59	MP0002572_abnormal_emotion/affect_behav	0.65584215
60	MP0003172_abnormal_lysosome_physiology	0.65494448
61	MP0002557_abnormal_social/conspecific_i	0.65115439
62	MP0001970_abnormal_pain_threshold	0.64446941
63	MP0002272_abnormal_nervous_system	0.59005427
64	MP0001984_abnormal_olfaction	0.57843038
65	MP0003880_abnormal_central_pattern	0.57319001
66	MP0009115_abnormal_fat_cell	0.57020215
67	MP0002734_abnormal_mechanical_nocicepti	0.56929293
68	MP0001879_abnormal_lymphatic_vessel	0.55418181
69	MP0005253_abnormal_eye_physiology	0.55385254
70	MP0000470_abnormal_stomach_morphology	0.53847910
71	MP0001666_abnormal_nutrient_absorption	0.51683464
72	MP0005375_adipose_tissue_phenotype	0.50177159
73	MP0005666_abnormal_adipose_tissue	0.49066215
74	MP0003119_abnormal_digestive_system	0.48696350
75	MP0000003_abnormal_adipose_tissue	0.47742343
76	MP0003635_abnormal_synaptic_transmissio	0.46719511
77	MP0003283_abnormal_digestive_organ	0.46625921
78	MP0009745_abnormal_behavioral_response	0.46467398
79	MP0001440_abnormal_grooming_behavior	0.45985818
80	MP0001501_abnormal_sleep_pattern	0.45662358
81	MP0005167_abnormal_blood-brain_barrier	0.45625047
82	MP0000566_synostosis	0.44315955
83	MP0008874_decreased_physiological_sensi	0.44207117
84	MP0003137_abnormal_impulse_conducting	0.43431623
85	MP0003699_abnormal_female_reproductive	0.43056739
86	MP0004484_altered_response_of	0.43055509
87	MP0005623_abnormal_meninges_morphology	0.42987684
88	MP0008961_abnormal_basal_metabolism	0.42797239
89	MP0002882_abnormal_neuron_morphology	0.36136958
90	MP0004233_abnormal_muscle_weight	0.35964152
91	MP0001270_distended_abdomen	0.35741710
92	MP0002254_reproductive_system_inflammat	0.35699745
93	MP0003936_abnormal_reproductive_system	0.35498513
94	MP0000249_abnormal_blood_vessel	0.35481297
95	MP0005084_abnormal_gallbladder_morpholo	0.35448479
96	MP0002928_abnormal_bile_duct	0.34141782
97	MP0009764_decreased_sensitivity_to	0.33998926
98	MP0005408_hypopigmentation	0.33773497
99	MP0003631_nervous_system_phenotype	0.33455760
100	MP0005535_abnormal_body_temperature	0.33212160

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	9.67792812
2	Bony spicule pigmentary retinopathy (HP:0007737)	5.62944324
3	Attenuation of retinal blood vessels (HP:0007843)	5.56470524
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.45641933
5	Absent/shortened dynein arms (HP:0200106)	5.45641933
6	Bell-shaped thorax (HP:0001591)	5.24683935
7	Abnormal rod and cone electroretinograms (HP:0008323)	5.05291500
8	Hypoplastic ischia (HP:0003175)	4.80300504
9	Enlarged epiphyses (HP:0010580)	4.79424460
10	Resting tremor (HP:0002322)	4.75909948
11	Asymmetric septal hypertrophy (HP:0001670)	4.73865317
12	Abnormal ciliary motility (HP:0012262)	4.38566320
13	Abnormal respiratory motile cilium physiology (HP:0012261)	4.27912664
14	Infertility (HP:0000789)	4.25919421
15	Abnormality of the ischium (HP:0003174)	4.17383075
16	Abnormal respiratory motile cilium morphology (HP:0005938)	4.10712601
17	Abnormal respiratory epithelium morphology (HP:0012253)	4.10712601
18	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.08973013
19	Azoospermia (HP:0000027)	4.06083237
20	Abnormality of macular pigmentation (HP:0008002)	3.97537041
21	Nasal polyposis (HP:0100582)	3.95767270
22	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.93871828
23	Tubulointerstitial nephritis (HP:0001970)	3.88743534
24	Male infertility (HP:0003251)	3.82346045
25	Potter facies (HP:0002009)	3.74134599
26	Facial shape deformation (HP:0011334)	3.74134599
27	Hyperkalemia (HP:0002153)	3.69566995
28	Abnormal spermatogenesis (HP:0008669)	3.64475964
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.63092800
30	Chronic hepatic failure (HP:0100626)	3.61565292
31	Unilateral renal agenesis (HP:0000122)	3.47458802
32	Generalized aminoaciduria (HP:0002909)	3.24212805
33	Abnormality of the nasal mucosa (HP:0000433)	3.18787450
34	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.07838467
35	Cone-rod dystrophy (HP:0000548)	3.04780535
36	Postural instability (HP:0002172)	2.97978361
37	Hypoplasia of the thymus (HP:0000778)	2.97611697
38	Epiphyseal dysplasia (HP:0002656)	2.87684171
39	Flattened epiphyses (HP:0003071)	2.86110712
40	Congenital malformation of the right heart (HP:0011723)	2.81138021
41	Double outlet right ventricle (HP:0001719)	2.81138021
42	Progressive sensorineural hearing impairment (HP:0000408)	2.76874384
43	Abnormality of the aortic arch (HP:0012303)	2.76634097
44	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.75553101
45	Absent epiphyses (HP:0010577)	2.75553101
46	Renal dysplasia (HP:0000110)	2.75030311
47	Impulsivity (HP:0100710)	2.71535304
48	Abnormal urine output (HP:0012590)	2.65971590
49	Rhinitis (HP:0012384)	2.59292984
50	Abnormality of the costochondral junction (HP:0000919)	2.40667298
51	Peripheral hypomyelination (HP:0007182)	2.40148300
52	Abnormality of the pubic bones (HP:0003172)	2.40096461
53	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.34545281
54	Nephronophthisis (HP:0000090)	2.30725312
55	Stage 5 chronic kidney disease (HP:0003774)	2.28355590
56	Abnormality of renal excretion (HP:0011036)	2.26682258
57	Abnormality of dental color (HP:0011073)	2.26038734
58	Abnormality of potassium homeostasis (HP:0011042)	2.25565339
59	Tetany (HP:0001281)	2.25557043
60	Hypoalphalipoproteinemia (HP:0003233)	2.23864640
61	Insulin-resistant diabetes mellitus (HP:0000831)	2.21931241
62	Upper limb muscle weakness (HP:0003484)	2.18858167
63	Abnormality of femoral epiphyses (HP:0006499)	2.18650645
64	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.18650645
65	Abnormality of the parathyroid morphology (HP:0011766)	2.17641365
66	Abnormal drinking behavior (HP:0030082)	2.14921015
67	Polydipsia (HP:0001959)	2.14921015
68	Mixed hearing impairment (HP:0000410)	2.11661948
69	Abnormality of the femoral head (HP:0003368)	2.11112205
70	Recurrent pneumonia (HP:0006532)	2.10239529
71	Protuberant abdomen (HP:0001538)	2.09122323
72	Osteomalacia (HP:0002749)	2.08930985
73	Truncal obesity (HP:0001956)	2.08595228
74	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.05730993
75	Polyuria (HP:0000103)	2.05533344
76	Widely patent fontanelles and sutures (HP:0004492)	2.05119321
77	Decreased central vision (HP:0007663)	2.04982175
78	Hypophosphatemic rickets (HP:0004912)	2.02948756
79	Flat capital femoral epiphysis (HP:0003370)	2.01521535
80	Portal hypertension (HP:0001409)	1.96934034
81	Renal Fanconi syndrome (HP:0001994)	1.95738641
82	Recurrent corneal erosions (HP:0000495)	1.95378926
83	Ventricular tachycardia (HP:0004756)	1.94860818
84	Amelogenesis imperfecta (HP:0000705)	1.94137689
85	Hyperthyroidism (HP:0000836)	1.93655755
86	Vertebral clefting (HP:0008428)	1.91521924
87	Hyponatremia (HP:0002902)	1.89370207
88	Myokymia (HP:0002411)	1.89302961
89	Abnormality of the renal medulla (HP:0100957)	1.88780924
90	Renovascular hypertension (HP:0100817)	1.88298455
91	Progressive cerebellar ataxia (HP:0002073)	1.87439703
92	Bronchiectasis (HP:0002110)	1.87142084
93	Focal segmental glomerulosclerosis (HP:0000097)	1.86032021
94	Short ribs (HP:0000773)	1.85831198
95	Muscle fiber atrophy (HP:0100295)	1.85761941
96	Hypoparathyroidism (HP:0000829)	1.84754460
97	Abnormal ventriculo-arterial connection (HP:0011563)	1.81701120
98	Transposition of the great arteries (HP:0001669)	1.81701120
99	Abnormal connection of the cardiac segments (HP:0011545)	1.81701120
100	Abnormality of the hepatic vasculature (HP:0006707)	1.81224125

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	6.66797306
2	TESK1	6.59090926
3	DDR2	6.54279056
4	MAP4K2	5.32350677
5	INSRR	4.03912185
6	STK38	3.54058649
7	STK38L	2.48693341
8	MAPK15	2.33663440
9	PLK2	2.30787539
10	PRKD3	2.24412223
11	BRD4	2.12502144
12	PNCK	2.06919756
13	MST1R	1.96859590
14	WNK1	1.68312093
15	CAMK1G	1.61898477
16	PDPK1	1.51288157
17	DYRK1B	1.48675101
18	MAP3K9	1.48031024
19	KSR2	1.43732220
20	PDK1	1.33171759
21	CDK7	1.28763878
22	PINK1	1.19863768
23	PIK3CG	1.14943299
24	NEK6	1.02120191
25	ARAF	1.01306085
26	CDK12	0.99559757
27	BRAF	0.90034530
28	RPS6KA2	0.88910730
29	PTK2B	0.87840707
30	PRKG2	0.77892749
31	MAP3K11	0.77137886
32	UHMK1	0.75022196
33	MAP2K2	0.73290011
34	MAP3K2	0.73093709
35	LATS2	0.71229265
36	RPS6KA1	0.69118600
37	MAP3K8	0.68834208
38	CDK4	0.68373236
39	MUSK	0.65896644
40	ROCK1	0.65431797
41	PRKG1	0.61560891
42	WNK4	0.60319126
43	CDK3	0.58009185
44	SIK2	0.56103872
45	PRKAA2	0.55690684
46	STK39	0.50670599
47	MAP3K1	0.49037680
48	CAMK1	0.47500927
49	RIPK4	0.46592186
50	LATS1	0.46558120
51	TESK2	0.46074292
52	RPS6KC1	0.45337323
53	RPS6KL1	0.45337323
54	CAMK1D	0.43767003
55	AKT3	0.42968908
56	RPS6KA6	0.41450822
57	GSK3B	0.41016252
58	TLK1	0.40903502
59	PRKCZ	0.37621465
60	PRKCG	0.37217587
61	CDK2	0.37068431
62	MAPK1	0.34958096
63	MAPK8	0.34883118
64	MTOR	0.32601766
65	CAMK4	0.31331388
66	CDK1	0.31154771
67	MARK2	0.30692428
68	BMPR1B	0.27661839
69	SGK223	0.26091602
70	SGK494	0.26091602
71	ABL2	0.25662790
72	MARK1	0.24975225
73	MAP2K7	0.24738214
74	DYRK3	0.23697187
75	BLK	0.23050651
76	PASK	0.22613066
77	IKBKB	0.22224351
78	CHEK1	0.22122078
79	MAP3K13	0.22039232
80	MINK1	0.21734017
81	MET	0.21650741
82	PKN1	0.19132334
83	PRKCB	0.18433764
84	MAPK10	0.17234619
85	OXSR1	0.17179370
86	MAP3K4	0.16164123
87	MAPK14	0.16017377
88	DYRK2	0.14131492
89	GRK7	0.13514303
90	ZAK	0.12459108
91	LMTK2	0.12298477
92	AKT1	0.12020684
93	CHUK	0.11930523
94	BRSK1	0.10377170
95	NTRK3	0.09728388
96	CAMK2A	0.08405434
97	TYRO3	0.08347292
98	PRKACA	0.08106137
99	MOS	0.08025567
100	ROCK2	0.07971544

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	9.28793243
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.47070113
3	Olfactory transduction_Homo sapiens_hsa04740	3.39252891
4	Butanoate metabolism_Homo sapiens_hsa00650	3.03751313
5	Allograft rejection_Homo sapiens_hsa05330	2.35300176
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.24306612
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.21650923
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.11782655
9	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.09572415
10	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.02636772
11	Antigen processing and presentation_Homo sapiens_hsa04612	1.83218876
12	Phenylalanine metabolism_Homo sapiens_hsa00360	1.70931976
13	Taste transduction_Homo sapiens_hsa04742	1.64889081
14	Viral myocarditis_Homo sapiens_hsa05416	1.54626278
15	Type II diabetes mellitus_Homo sapiens_hsa04930	1.54179409
16	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.46761554
17	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.45458136
18	Fatty acid degradation_Homo sapiens_hsa00071	1.43028017
19	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.35611459
20	Fatty acid metabolism_Homo sapiens_hsa01212	1.31881338
21	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.29420384
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.26464413
23	Endocytosis_Homo sapiens_hsa04144	1.21196252
24	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.20990632
25	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.18786240
26	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.05634692
27	RNA transport_Homo sapiens_hsa03013	1.02964484
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01264481
29	Arginine biosynthesis_Homo sapiens_hsa00220	1.00641817
30	Salivary secretion_Homo sapiens_hsa04970	1.00424597
31	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.99698386
32	Phototransduction_Homo sapiens_hsa04744	0.95702566
33	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.91666571
34	Selenocompound metabolism_Homo sapiens_hsa00450	0.89376883
35	Morphine addiction_Homo sapiens_hsa05032	0.87565783
36	Protein digestion and absorption_Homo sapiens_hsa04974	0.84766818
37	Influenza A_Homo sapiens_hsa05164	0.84382782
38	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83250711
39	PPAR signaling pathway_Homo sapiens_hsa03320	0.78092968
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.75383378
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74016663
42	Oocyte meiosis_Homo sapiens_hsa04114	0.73678510
43	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.72293157
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.69713385
45	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.69213108
46	Nicotine addiction_Homo sapiens_hsa05033	0.68698849
47	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.68467278
48	cAMP signaling pathway_Homo sapiens_hsa04024	0.67940899
49	Estrogen signaling pathway_Homo sapiens_hsa04915	0.67566995
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.64159688
51	Renin-angiotensin system_Homo sapiens_hsa04614	0.63185774
52	Circadian entrainment_Homo sapiens_hsa04713	0.60673356
53	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.57371715
54	ABC transporters_Homo sapiens_hsa02010	0.52811117
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.52509227
56	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.51209258
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.50493856
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.48726074
59	Retinol metabolism_Homo sapiens_hsa00830	0.47613272
60	Purine metabolism_Homo sapiens_hsa00230	0.46570791
61	Gastric acid secretion_Homo sapiens_hsa04971	0.45535335
62	Insulin secretion_Homo sapiens_hsa04911	0.45230834
63	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.45170332
64	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.42831931
65	MAPK signaling pathway_Homo sapiens_hsa04010	0.41104783
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.40099049
67	VEGF signaling pathway_Homo sapiens_hsa04370	0.39462282
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.38513767
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38496097
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36944216
71	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.36150879
72	Renin secretion_Homo sapiens_hsa04924	0.33599811
73	Cholinergic synapse_Homo sapiens_hsa04725	0.32970440
74	GABAergic synapse_Homo sapiens_hsa04727	0.32340731
75	Acute myeloid leukemia_Homo sapiens_hsa05221	0.28162796
76	Tight junction_Homo sapiens_hsa04530	0.27938668
77	Serotonergic synapse_Homo sapiens_hsa04726	0.27859617
78	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.27619228
79	Basal transcription factors_Homo sapiens_hsa03022	0.27477972
80	Herpes simplex infection_Homo sapiens_hsa05168	0.26312664
81	Phagosome_Homo sapiens_hsa04145	0.26198516
82	Bile secretion_Homo sapiens_hsa04976	0.25574535
83	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.24656104
84	Legionellosis_Homo sapiens_hsa05134	0.24655304
85	Viral carcinogenesis_Homo sapiens_hsa05203	0.24260944
86	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.22165464
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.21663844
88	Toxoplasmosis_Homo sapiens_hsa05145	0.21007654
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.20935046
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.20842367
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.20835542
92	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.17596528
93	Huntingtons disease_Homo sapiens_hsa05016	0.16783320
94	Metabolic pathways_Homo sapiens_hsa01100	0.16268390
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.15843558
96	Sulfur relay system_Homo sapiens_hsa04122	0.15417142
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.14704971
98	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.13545919
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.10043215
100	Alcoholism_Homo sapiens_hsa05034	0.09354246

TMEM191B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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