TMEM191C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.87429185
2response to pheromone (GO:0019236)9.77354630
3sperm capacitation (GO:0048240)7.87255875
4spermatid development (GO:0007286)7.60349818
5plasma membrane fusion (GO:0045026)7.57212017
6single strand break repair (GO:0000012)7.53871624
7microtubule depolymerization (GO:0007019)7.42278497
8chromosome condensation (GO:0030261)7.27814972
9spermatid nucleus differentiation (GO:0007289)7.21599398
10DNA packaging (GO:0006323)7.10458785
11multicellular organism reproduction (GO:0032504)7.09193457
12sperm-egg recognition (GO:0035036)6.89456671
13regulation of short-term neuronal synaptic plasticity (GO:0048172)6.62653944
14protein polyglutamylation (GO:0018095)6.62005282
15reproduction (GO:0000003)6.33186992
16cellular ketone body metabolic process (GO:0046950)6.15300987
17axonemal dynein complex assembly (GO:0070286)6.10818808
18rRNA methylation (GO:0031167)6.04361692
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.01629509
20microtubule polymerization or depolymerization (GO:0031109)5.98312057
21binding of sperm to zona pellucida (GO:0007339)5.89664708
22phosphatidylethanolamine biosynthetic process (GO:0006646)5.83357503
23regulation of cilium movement (GO:0003352)5.77617981
24cell-cell recognition (GO:0009988)5.70033465
25synaptic vesicle maturation (GO:0016188)5.60572483
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.55063877
27protein targeting to Golgi (GO:0000042)5.46679203
28ketone body metabolic process (GO:1902224)5.45076117
29synaptic vesicle exocytosis (GO:0016079)5.44555351
30phosphatidylethanolamine metabolic process (GO:0046337)5.42577879
31spermatogenesis (GO:0007283)5.40994886
32locomotory exploration behavior (GO:0035641)5.39986500
33male gamete generation (GO:0048232)5.39518493
34establishment of protein localization to Golgi (GO:0072600)5.39400823
35vocalization behavior (GO:0071625)5.37760182
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.31937962
37ionotropic glutamate receptor signaling pathway (GO:0035235)5.27986637
38protein localization to synapse (GO:0035418)5.27884731
39microtubule severing (GO:0051013)5.22409079
40sexual reproduction (GO:0019953)5.17829268
41negative regulation of inclusion body assembly (GO:0090084)5.17083759
42rRNA modification (GO:0000154)5.16177686
43regulation of glutamate receptor signaling pathway (GO:1900449)5.12027423
44centriole replication (GO:0007099)5.10145430
45retrograde transport, vesicle recycling within Golgi (GO:0000301)4.99167321
46synaptic vesicle docking involved in exocytosis (GO:0016081)4.98770681
47gamete generation (GO:0007276)4.93806396
48cilium or flagellum-dependent cell motility (GO:0001539)4.91652103
49neuronal action potential propagation (GO:0019227)4.88457529
50regulation of synaptic vesicle exocytosis (GO:2000300)4.87492793
51glutamate secretion (GO:0014047)4.87388027
52synaptic transmission, glutamatergic (GO:0035249)4.84033126
53regulation of long-term neuronal synaptic plasticity (GO:0048169)4.74605824
54regulation of Rab GTPase activity (GO:0032313)4.72217864
55positive regulation of Rab GTPase activity (GO:0032851)4.72217864
56regulation of neuronal synaptic plasticity (GO:0048168)4.69611596
57epithelial cilium movement (GO:0003351)4.62047396
58neuron-neuron synaptic transmission (GO:0007270)4.53724885
59single fertilization (GO:0007338)4.52945517
60glutamate receptor signaling pathway (GO:0007215)4.52313467
61motile cilium assembly (GO:0044458)4.51824557
62neuron cell-cell adhesion (GO:0007158)4.51720051
63regulation of synaptic vesicle transport (GO:1902803)4.49299657
64exploration behavior (GO:0035640)4.43561050
65regulation of synapse structural plasticity (GO:0051823)4.42058141
66cell wall macromolecule catabolic process (GO:0016998)4.40057915
67coenzyme catabolic process (GO:0009109)4.37584453
68cell wall macromolecule metabolic process (GO:0044036)4.36026639
69centriole assembly (GO:0098534)4.34441483
70neurotransmitter secretion (GO:0007269)4.34420889
71RNA destabilization (GO:0050779)4.30534966
72regulation of transcription involved in cell fate commitment (GO:0060850)4.28919457
73regulation of microtubule-based movement (GO:0060632)4.26064929
74germ cell development (GO:0007281)4.23776479
75positive regulation of membrane potential (GO:0045838)4.22433527
76protein localization to Golgi apparatus (GO:0034067)4.18597436
77regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18162683
78long-term memory (GO:0007616)4.16164387
79regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08677531
80neurotransmitter-gated ion channel clustering (GO:0072578)4.06558453
81positive regulation of synaptic transmission, GABAergic (GO:0032230)4.02161619
82neuromuscular process controlling posture (GO:0050884)4.01897721
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.98047709
84positive regulation of synapse maturation (GO:0090129)3.96993903
85cilium movement (GO:0003341)3.93047803
86cellular process involved in reproduction in multicellular organism (GO:0022412)3.90441351
87organic cation transport (GO:0015695)3.90274897
88multicellular organismal reproductive process (GO:0048609)3.89103807
89positive regulation of neurotransmitter secretion (GO:0001956)3.88542894
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87204240
91regulation of postsynaptic membrane potential (GO:0060078)3.86821388
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84560047
93positive regulation of neurotransmitter transport (GO:0051590)3.81699626
94chromatin silencing (GO:0006342)3.81543366
95dendritic spine morphogenesis (GO:0060997)3.76928216
96transmission of nerve impulse (GO:0019226)3.74607605
97regulation of synaptic plasticity (GO:0048167)3.71373315
98regulation of centriole replication (GO:0046599)3.71151365
99gamma-aminobutyric acid signaling pathway (GO:0007214)3.69499325
100regulation of synaptic transmission, glutamatergic (GO:0051966)3.68740178
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68205030
102regulation of inclusion body assembly (GO:0090083)3.67708905
103negative regulation of Rho protein signal transduction (GO:0035024)3.66372007
104seminiferous tubule development (GO:0072520)3.66045024
105fertilization (GO:0009566)3.65003202
106regulation of dendritic spine morphogenesis (GO:0061001)3.63799925
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62957183
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.61925607
109neurotransmitter transport (GO:0006836)3.61069002
110long-term synaptic potentiation (GO:0060291)3.58424053
111cellular potassium ion homeostasis (GO:0030007)3.57543176
112gamma-aminobutyric acid transport (GO:0015812)3.53574841
113behavioral fear response (GO:0001662)3.52769278
114behavioral defense response (GO:0002209)3.52769278
115prepulse inhibition (GO:0060134)3.52089266
116layer formation in cerebral cortex (GO:0021819)3.51849116
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.49637884
118regulation of neurotransmitter secretion (GO:0046928)3.47274556
119neuron recognition (GO:0008038)3.46958002
120positive regulation of dendritic spine morphogenesis (GO:0061003)3.46821765
121response to histamine (GO:0034776)3.46704189
122positive regulation of dendritic spine development (GO:0060999)3.44027965
123striatum development (GO:0021756)3.43884095
124synaptic vesicle endocytosis (GO:0048488)3.43485810
125synaptic transmission, dopaminergic (GO:0001963)3.43460749
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40363165
127neuromuscular process controlling balance (GO:0050885)3.38770727
128auditory behavior (GO:0031223)3.37815778
129membrane depolarization (GO:0051899)3.37320252
130regulation of neurotransmitter levels (GO:0001505)3.36432712
131regulation of vesicle fusion (GO:0031338)3.35451061
132membrane depolarization during action potential (GO:0086010)3.33853341
133postsynaptic membrane organization (GO:0001941)3.33638767
134peptidyl-threonine dephosphorylation (GO:0035970)3.33114297
135neuronal ion channel clustering (GO:0045161)3.31219013
136regulation of glutamate secretion (GO:0014048)3.29272981
137regulation of neurotransmitter transport (GO:0051588)3.29117454
138membrane hyperpolarization (GO:0060081)3.28031510
139learning (GO:0007612)3.26952269
140negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26434588
141multicellular organismal movement (GO:0050879)3.26237193
142musculoskeletal movement (GO:0050881)3.26237193
143behavioral response to cocaine (GO:0048148)3.24808422
144fear response (GO:0042596)3.24788488
145calcium ion-dependent exocytosis (GO:0017156)3.21981051
146positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20838136
147NAD biosynthetic process (GO:0009435)3.20208847
148adult walking behavior (GO:0007628)3.19815390
149regulation of synapse maturation (GO:0090128)3.19246277
150response to acidic pH (GO:0010447)3.18367335
151presynaptic membrane assembly (GO:0097105)3.14859946
152startle response (GO:0001964)3.14175378
153proline transport (GO:0015824)3.13956832
154activation of protein kinase A activity (GO:0034199)3.13813156
155response to auditory stimulus (GO:0010996)3.13508684
156positive regulation of synaptic transmission (GO:0050806)3.12715052
157negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.11290744
158synaptic transmission (GO:0007268)3.06708158
159regulation of dendritic spine development (GO:0060998)3.06071347
160regulation of synaptic transmission (GO:0050804)3.05243836
161piRNA metabolic process (GO:0034587)3.03501306
162polyamine biosynthetic process (GO:0006596)3.02986387
163glycerol ether metabolic process (GO:0006662)3.01275081
164axonal fasciculation (GO:0007413)3.00604816
165nucleus organization (GO:0006997)3.00346869
166cerebellar Purkinje cell differentiation (GO:0021702)2.99695187
167spinal cord motor neuron differentiation (GO:0021522)2.98585933
168sodium ion export (GO:0071436)2.98426968
169neuromuscular process (GO:0050905)2.97909140
170male meiosis I (GO:0007141)2.97779269
171presynaptic membrane organization (GO:0097090)2.97633141
172alanine transport (GO:0032328)2.97475019
173cell recognition (GO:0008037)2.96208635
174cranial nerve morphogenesis (GO:0021602)2.95197971
175response to amphetamine (GO:0001975)2.94988406
176mechanosensory behavior (GO:0007638)2.94703684
177regulation of protein kinase A signaling (GO:0010738)2.93410466
178cellular response to pH (GO:0071467)2.92563274
179male meiosis (GO:0007140)2.90206901
180DNA methylation involved in gamete generation (GO:0043046)2.89523546
181ether metabolic process (GO:0018904)2.87444565
182positive regulation of guanylate cyclase activity (GO:0031284)2.84798888
183detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.83348891
184axoneme assembly (GO:0035082)2.83105991
185cerebral cortex neuron differentiation (GO:0021895)2.81328032
186positive regulation of action potential (GO:0045760)2.79823683
187multicellular organismal development (GO:0007275)2.78812632
188cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.78332871
189cilium organization (GO:0044782)2.77041379
190somite rostral/caudal axis specification (GO:0032525)2.76875599
191cilium assembly (GO:0042384)2.73928226
192regulation of phosphoprotein phosphatase activity (GO:0043666)2.70088221
193nephron tubule morphogenesis (GO:0072078)2.68710169
194nephron epithelium morphogenesis (GO:0072088)2.68710169
195regulation of guanylate cyclase activity (GO:0031282)2.65608606
196cofactor catabolic process (GO:0051187)2.61134813
197microtubule nucleation (GO:0007020)2.55871698
198acrosome reaction (GO:0007340)11.1226370
199sperm motility (GO:0030317)10.7421527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.10118944
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.32096800
3REST_21632747_ChIP-Seq_MESCs_Mouse3.30534900
4GBX2_23144817_ChIP-Seq_PC3_Human3.29061667
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.10751270
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09169939
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02357669
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.92278995
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76567828
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.73063921
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65515359
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.63434706
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56965401
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52841288
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52841288
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.51375263
17DROSHA_22980978_ChIP-Seq_HELA_Human2.51067277
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46152589
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43745678
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42385961
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.42373455
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34052173
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24968319
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23852366
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23264752
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.19410699
27CBP_20019798_ChIP-Seq_JUKART_Human2.19410699
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17039424
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.12117979
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08870032
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.02763150
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99577144
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99521666
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98796673
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.93733676
36ERA_21632823_ChIP-Seq_H3396_Human1.92694982
37ER_23166858_ChIP-Seq_MCF-7_Human1.91730708
38VDR_22108803_ChIP-Seq_LS180_Human1.86848212
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.84970293
40NANOG_20526341_ChIP-Seq_ESCs_Human1.80513245
41VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.80483491
42TAF15_26573619_Chip-Seq_HEK293_Human1.80059827
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77567990
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75248972
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.70000396
46EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.66734630
47* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.66001465
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64988139
49RAC3_21632823_ChIP-Seq_H3396_Human1.62840309
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.59079288
51MYC_19829295_ChIP-Seq_ESCs_Human1.59062050
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57757497
53TAF2_19829295_ChIP-Seq_ESCs_Human1.55848972
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55531491
55ZNF274_21170338_ChIP-Seq_K562_Hela1.55303026
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.54073282
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.51499674
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.51419632
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49139324
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48115445
61OCT4_20526341_ChIP-Seq_ESCs_Human1.47928138
62TDRD3_21172665_ChIP-Seq_MCF-7_Human1.47870518
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44065814
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43835280
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38100731
66E2F1_20622854_ChIP-Seq_HELA_Human1.38003110
67NANOG_19829295_ChIP-Seq_ESCs_Human1.34509867
68SOX2_19829295_ChIP-Seq_ESCs_Human1.34509867
69SMAD4_21799915_ChIP-Seq_A2780_Human1.34223512
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34222311
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34068361
72AR_21572438_ChIP-Seq_LNCaP_Human1.30444842
73* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29955690
74BCL6_27268052_Chip-Seq_Bcells_Human1.29862322
75YY1_22570637_ChIP-Seq_MALME-3M_Human1.29499443
76ERG_20517297_ChIP-Seq_VCAP_Human1.28948023
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28903363
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27953236
79CTCF_20526341_ChIP-Seq_ESCs_Human1.26770515
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.26763012
81PHF8_20622854_ChIP-Seq_HELA_Human1.25780858
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24840906
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22689833
84RBPJ_21746931_ChIP-Seq_IB4_Human1.21861896
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.21858040
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21858040
87ETV1_20927104_ChIP-Seq_GIST48_Human1.21684866
88HOXB7_26014856_ChIP-Seq_BT474_Human1.20400629
89P53_21459846_ChIP-Seq_SAOS-2_Human1.20237079
90HNFA_21074721_ChIP-Seq_CACO-2_Human1.19192428
91CBX2_22325352_ChIP-Seq_293T-Rex_Human1.19183715
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18263972
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16593773
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15932321
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.15132251
96P300_27268052_Chip-Seq_Bcells_Human1.14616503
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.14331758
98CTCF_27219007_Chip-Seq_Bcells_Human1.14106972
99NCOR_22424771_ChIP-Seq_293T_Human1.13903790
100TBL1_22424771_ChIP-Seq_293T_Human1.13119464
101EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12548748
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12294880
103RNF2_27304074_Chip-Seq_NSC_Mouse1.11975561
104NFYB_21822215_ChIP-Seq_K562_Human1.11678687
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11161767
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09513774
107BCOR_27268052_Chip-Seq_Bcells_Human1.09195140
108CEBPB_22108803_ChIP-Seq_LS180_Human1.08646935
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08326992
110PHF8_20622853_ChIP-Seq_HELA_Human1.07284090
111SMRT_27268052_Chip-Seq_Bcells_Human1.07076773
112TP53_18474530_ChIP-ChIP_U2OS_Human1.06687360
113OCT1_27270436_Chip-Seq_PROSTATE_Human1.04778239
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.03718909
115FOXH1_21741376_ChIP-Seq_EPCs_Human1.03551578
116P300_19829295_ChIP-Seq_ESCs_Human1.03303811
117P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.03060834
118FOXH1_21741376_ChIP-Seq_ESCs_Human1.02591738
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02256798
120P68_20966046_ChIP-Seq_HELA_Human1.02182822
121KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.02110881
122AR_25329375_ChIP-Seq_VCAP_Human1.01914248
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.01071650
124ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00972888
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00846993
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.99942621
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99446576
128FUS_26573619_Chip-Seq_HEK293_Human0.98540171
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96164517
130RING1B_27294783_Chip-Seq_NPCs_Mouse0.93697516
131AR_19668381_ChIP-Seq_PC3_Human0.93127953
132STAT3_23295773_ChIP-Seq_U87_Human0.93074876
133TCF4_23295773_ChIP-Seq_U87_Human0.90458519
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89808299
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.89779590
136GATA1_26923725_Chip-Seq_HPCs_Mouse0.88971757
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88584416
138KDM2B_26808549_Chip-Seq_K562_Human0.88384288
139SMC4_20622854_ChIP-Seq_HELA_Human0.86997579
140KLF4_19829295_ChIP-Seq_ESCs_Human0.86978976
141RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86152525
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85261250
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83364537
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80992093
145VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79754371
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79497088
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79412725
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79192693
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79160351
150POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79160351
151RUNX2_22187159_ChIP-Seq_PCA_Human0.78344666
152WDR5_24793694_ChIP-Seq_LNCAP_Human0.76413556
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.75164579
154SMAD_19615063_ChIP-ChIP_OVARY_Human0.74534095
155DPY_21335234_ChIP-Seq_ESCs_Mouse0.73879894
156YAP1_20516196_ChIP-Seq_MESCs_Mouse0.73817312
157* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.73674763
158OCT4_19829295_ChIP-Seq_ESCs_Human0.72355077
159CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72285104
160MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.71936657
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.71559478
162JUN_21703547_ChIP-Seq_K562_Human0.70945549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.59976067
2MP0003880_abnormal_central_pattern5.42496188
3MP0003878_abnormal_ear_physiology4.23934775
4MP0005377_hearing/vestibular/ear_phenot4.23934775
5MP0003635_abnormal_synaptic_transmissio4.18239920
6MP0002822_catalepsy4.10078102
7MP0009745_abnormal_behavioral_response3.56030053
8MP0002063_abnormal_learning/memory/cond3.29840740
9MP0004270_analgesia3.29460411
10MP0002064_seizures3.27236787
11MP0001929_abnormal_gametogenesis3.26488628
12MP0005670_abnormal_white_adipose3.22767870
13MP0009046_muscle_twitch3.10671176
14MP0005423_abnormal_somatic_nervous2.90704130
15MP0002572_abnormal_emotion/affect_behav2.86907209
16MP0001968_abnormal_touch/_nociception2.80602663
17MP0002272_abnormal_nervous_system2.70633423
18MP0001486_abnormal_startle_reflex2.65486971
19MP0001501_abnormal_sleep_pattern2.47961423
20MP0001348_abnormal_lacrimal_gland2.41889686
21MP0002736_abnormal_nociception_after2.24383734
22MP0002734_abnormal_mechanical_nocicepti2.21205473
23MP0003011_delayed_dark_adaptation2.11023216
24MP0002161_abnormal_fertility/fecundity2.06489577
25MP0001440_abnormal_grooming_behavior2.04598824
26MP0003718_maternal_effect2.01687926
27MP0001529_abnormal_vocalization1.94963583
28MP0002067_abnormal_sensory_capabilities1.92878654
29MP0003879_abnormal_hair_cell1.86362631
30MP0001970_abnormal_pain_threshold1.85852913
31MP0002735_abnormal_chemical_nociception1.85666937
32MP0002733_abnormal_thermal_nociception1.80061245
33MP0008569_lethality_at_weaning1.77295239
34MP0005379_endocrine/exocrine_gland_phen1.75293300
35MP0002557_abnormal_social/conspecific_i1.74704363
36MP0002909_abnormal_adrenal_gland1.70526679
37MP0003329_amyloid_beta_deposits1.69771312
38MP0004924_abnormal_behavior1.69465894
39MP0005386_behavior/neurological_phenoty1.69465894
40MP0004811_abnormal_neuron_physiology1.66934170
41MP0002184_abnormal_innervation1.65670424
42MP0000678_abnormal_parathyroid_gland1.63893346
43MP0002210_abnormal_sex_determination1.62352621
44MP0004142_abnormal_muscle_tone1.62132267
45MP0001984_abnormal_olfaction1.60568356
46MP0005410_abnormal_fertilization1.59837215
47MP0006292_abnormal_olfactory_placode1.59319665
48MP0001188_hyperpigmentation1.57779430
49MP0006276_abnormal_autonomic_nervous1.55213730
50MP0002132_abnormal_respiratory_system1.53044138
51MP0005646_abnormal_pituitary_gland1.47754348
52MP0003787_abnormal_imprinting1.46428646
53MP0000955_abnormal_spinal_cord1.45962277
54MP0001502_abnormal_circadian_rhythm1.45362065
55MP0001905_abnormal_dopamine_level1.44397387
56MP0002066_abnormal_motor_capabilities/c1.38898449
57MP0002882_abnormal_neuron_morphology1.37592608
58MP0000778_abnormal_nervous_system1.37452037
59MP0004885_abnormal_endolymph1.35977460
60MP0001145_abnormal_male_reproductive1.33543451
61MP0002282_abnormal_trachea_morphology1.30220652
62MP0000653_abnormal_sex_gland1.29283709
63MP0005645_abnormal_hypothalamus_physiol1.25200626
64MP0005253_abnormal_eye_physiology1.20982519
65MP0002653_abnormal_ependyma_morphology1.16299347
66MP0004858_abnormal_nervous_system1.15971067
67MP0003633_abnormal_nervous_system1.13956862
68MP0005310_abnormal_salivary_gland1.13613826
69MP0002138_abnormal_hepatobiliary_system1.13065493
70MP0001765_abnormal_ion_homeostasis1.11665994
71MP0005551_abnormal_eye_electrophysiolog1.09258633
72MP0005084_abnormal_gallbladder_morpholo1.09029974
73MP0008872_abnormal_physiological_respon1.07646747
74MP0002152_abnormal_brain_morphology1.05362149
75MP0003122_maternal_imprinting1.04755135
76MP0002229_neurodegeneration1.03366627
77MP0008877_abnormal_DNA_methylation1.01297702
78MP0005409_darkened_coat_color1.00631242
79MP0004742_abnormal_vestibular_system0.99026712
80MP0002249_abnormal_larynx_morphology0.98957687
81MP0008874_decreased_physiological_sensi0.98347379
82MP0002069_abnormal_eating/drinking_beha0.97325632
83MP0002102_abnormal_ear_morphology0.95898204
84MP0008995_early_reproductive_senescence0.93014175
85MP0000751_myopathy0.92694334
86MP0003631_nervous_system_phenotype0.90703345
87MP0003698_abnormal_male_reproductive0.90247035
88MP0009780_abnormal_chondrocyte_physiolo0.90132536
89MP0005167_abnormal_blood-brain_barrier0.85807687
90MP0001963_abnormal_hearing_physiology0.85397246
91MP0000049_abnormal_middle_ear0.83945335
92MP0002837_dystrophic_cardiac_calcinosis0.83893614
93MP0000631_abnormal_neuroendocrine_gland0.83689910
94MP0005395_other_phenotype0.82534935
95MP0001664_abnormal_digestion0.80700271
96MP0002752_abnormal_somatic_nervous0.80327293
97MP0004145_abnormal_muscle_electrophysio0.79898794
98MP0002928_abnormal_bile_duct0.79757139
99MP0003123_paternal_imprinting0.77125169
100MP0003283_abnormal_digestive_organ0.76928790
101MP0005535_abnormal_body_temperature0.76807886
102MP0002127_abnormal_cardiovascular_syste0.76795907
103MP0003136_yellow_coat_color0.76546395
104MP0000516_abnormal_urinary_system0.76411029
105MP0005367_renal/urinary_system_phenotyp0.76411029
106MP0008961_abnormal_basal_metabolism0.76337653
107MP0008875_abnormal_xenobiotic_pharmacok0.76164889
108MP0001485_abnormal_pinna_reflex0.74993801
109MP0002234_abnormal_pharynx_morphology0.74896675
110MP0003119_abnormal_digestive_system0.74663437
111MP0005636_abnormal_mineral_homeostasis0.74352769
112MP0001986_abnormal_taste_sensitivity0.72393596
113MP0000534_abnormal_ureter_morphology0.69789121
114MP0003634_abnormal_glial_cell0.68439666
115MP0003195_calcinosis0.68064547
116MP0005499_abnormal_olfactory_system0.67982928
117MP0005394_taste/olfaction_phenotype0.67982928
118MP0002160_abnormal_reproductive_system0.67622593
119MP0006072_abnormal_retinal_apoptosis0.66768958
120MP0003075_altered_response_to0.66661751
121MP0002090_abnormal_vision0.66456968
122MP0009053_abnormal_anal_canal0.66222537
123MP0004085_abnormal_heartbeat0.65637887
124MP0005248_abnormal_Harderian_gland0.65555898
125MP0000920_abnormal_myelination0.64837518
126MP0001177_atelectasis0.64809216
127MP0000569_abnormal_digit_pigmentation0.64358156
128MP0004233_abnormal_muscle_weight0.61970866
129MP0010386_abnormal_urinary_bladder0.61892467
130MP0003646_muscle_fatigue0.61538218
131MP0003121_genomic_imprinting0.60204214
132MP0004484_altered_response_of0.59070891
133MP0002638_abnormal_pupillary_reflex0.58959909
134MP0000604_amyloidosis0.58563651
135MP0000681_abnormal_thyroid_gland0.57355072
136MP0000026_abnormal_inner_ear0.57123115
137MP0000013_abnormal_adipose_tissue0.56899776
138MP0010769_abnormal_survival0.55644515
139MP0003137_abnormal_impulse_conducting0.55137826
140MP0003861_abnormal_nervous_system0.55106592
141MP0010768_mortality/aging0.54412508
142MP0003938_abnormal_ear_development0.54399326
143MP0003956_abnormal_body_size0.53775899
144MP0010770_preweaning_lethality0.53286808
145MP0002082_postnatal_lethality0.53286808

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.10186903
2Myokymia (HP:0002411)6.79195210
3Focal seizures (HP:0007359)5.71735348
4Attenuation of retinal blood vessels (HP:0007843)5.41939355
5Visual hallucinations (HP:0002367)5.20776111
6Bony spicule pigmentary retinopathy (HP:0007737)4.96899825
7Epileptic encephalopathy (HP:0200134)4.84173189
8Abnormal rod and cone electroretinograms (HP:0008323)4.64074391
9Atonic seizures (HP:0010819)4.56121024
10Febrile seizures (HP:0002373)4.52230527
11Chronic hepatic failure (HP:0100626)4.21756555
12Absence seizures (HP:0002121)4.02665145
13Dialeptic seizures (HP:0011146)3.94285074
14Nephronophthisis (HP:0000090)3.79029269
15Abnormality of macular pigmentation (HP:0008002)3.74572515
16Progressive cerebellar ataxia (HP:0002073)3.64828845
17Generalized tonic-clonic seizures (HP:0002069)3.63756116
18Ankle clonus (HP:0011448)3.56256213
19Broad-based gait (HP:0002136)3.54981057
20Infertility (HP:0000789)3.49362179
21Gaze-evoked nystagmus (HP:0000640)3.45663405
22Hypoplastic ischia (HP:0003175)3.39155443
23Tubulointerstitial nephritis (HP:0001970)3.38590904
24Hyperkalemia (HP:0002153)3.34192594
25Absent/shortened dynein arms (HP:0200106)3.32457822
26Dynein arm defect of respiratory motile cilia (HP:0012255)3.32457822
27Impaired vibration sensation in the lower limbs (HP:0002166)3.31179894
28Poor eye contact (HP:0000817)3.29930315
29Supranuclear gaze palsy (HP:0000605)3.26483613
30Facial shape deformation (HP:0011334)3.21764055
31Potter facies (HP:0002009)3.21764055
32Asymmetric septal hypertrophy (HP:0001670)3.19553372
33Azoospermia (HP:0000027)3.18835714
34Abnormality of the renal medulla (HP:0100957)3.18272213
35Urinary bladder sphincter dysfunction (HP:0002839)3.13256709
36Mutism (HP:0002300)3.09779056
37Bell-shaped thorax (HP:0001591)3.06317282
38Abnormal drinking behavior (HP:0030082)3.02908686
39Polydipsia (HP:0001959)3.02908686
40Depression (HP:0000716)3.00499194
41Enlarged epiphyses (HP:0010580)3.00141252
42Abnormal spermatogenesis (HP:0008669)2.95152743
43Resting tremor (HP:0002322)2.94896849
44Anxiety (HP:0000739)2.94710542
45Pancreatic fibrosis (HP:0100732)2.93387740
46Abnormal social behavior (HP:0012433)2.92754609
47Impaired social interactions (HP:0000735)2.92754609
48Abnormal urine output (HP:0012590)2.89609926
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.89453244
50Abnormality of the lower motor neuron (HP:0002366)2.89350403
51Pancreatic cysts (HP:0001737)2.86562063
52Abnormality of the ischium (HP:0003174)2.85300718
53Truncal ataxia (HP:0002078)2.82653038
54Abnormal eating behavior (HP:0100738)2.80468842
55Hemiparesis (HP:0001269)2.77848043
56Impulsivity (HP:0100710)2.76726259
57Dysdiadochokinesis (HP:0002075)2.76100421
58Dysmetria (HP:0001310)2.75472704
59Spastic gait (HP:0002064)2.73774649
60Postural instability (HP:0002172)2.73379249
61Nasal polyposis (HP:0100582)2.73002943
62Male infertility (HP:0003251)2.72047275
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.70612839
64Polyuria (HP:0000103)2.70274507
65Annular pancreas (HP:0001734)2.69479664
66Progressive inability to walk (HP:0002505)2.67938852
67Impaired smooth pursuit (HP:0007772)2.67613509
68Delusions (HP:0000746)2.67350801
69Type II lissencephaly (HP:0007260)2.66273874
70Action tremor (HP:0002345)2.65597602
71Aplasia/Hypoplasia of the earlobes (HP:0009906)2.64702388
72Decreased central vision (HP:0007663)2.64551773
73Amblyopia (HP:0000646)2.64008166
74Congenital stationary night blindness (HP:0007642)2.62512537
75Torticollis (HP:0000473)2.59493458
76Hyperventilation (HP:0002883)2.57802403
77Rhinitis (HP:0012384)2.56952594
78Stereotypic behavior (HP:0000733)2.54567531
79Abnormality of renal excretion (HP:0011036)2.54152159
80Genetic anticipation (HP:0003743)2.53574508
81Double outlet right ventricle (HP:0001719)2.51773097
82Congenital malformation of the right heart (HP:0011723)2.51773097
83Fetal akinesia sequence (HP:0001989)2.51543960
84True hermaphroditism (HP:0010459)2.50711143
85Bradykinesia (HP:0002067)2.49850347
86Urinary urgency (HP:0000012)2.48561025
87Focal dystonia (HP:0004373)2.46702125
88Pendular nystagmus (HP:0012043)2.45859624
89Excessive salivation (HP:0003781)2.43257779
90Drooling (HP:0002307)2.43257779
91Retinal dysplasia (HP:0007973)2.43167200
92Abnormal respiratory epithelium morphology (HP:0012253)2.41967197
93Abnormal respiratory motile cilium morphology (HP:0005938)2.41967197
94Molar tooth sign on MRI (HP:0002419)2.41054749
95Abnormality of midbrain morphology (HP:0002418)2.41054749
96Generalized aminoaciduria (HP:0002909)2.38964115
97Scanning speech (HP:0002168)2.38201084
98Renal dysplasia (HP:0000110)2.37923949
99Hypoplasia of the thymus (HP:0000778)2.37174220
100Optic nerve hypoplasia (HP:0000609)2.36958404
101Ventricular fibrillation (HP:0001663)2.36286329
102Abnormality of ocular smooth pursuit (HP:0000617)2.36094020
103Abnormality of the aortic arch (HP:0012303)2.33938719
104Stage 5 chronic kidney disease (HP:0003774)2.31509479
105Inability to walk (HP:0002540)2.31257313
106Tubular atrophy (HP:0000092)2.28373271
107Cerebellar dysplasia (HP:0007033)2.28214187
108Unilateral renal agenesis (HP:0000122)2.28148079
109Cone-rod dystrophy (HP:0000548)2.24823826
110Bundle branch block (HP:0011710)2.23683365
111Abnormality of potassium homeostasis (HP:0011042)2.22034778
112Abnormality of dental color (HP:0011073)2.21019681
113Amelogenesis imperfecta (HP:0000705)2.19439297
114Epileptiform EEG discharges (HP:0011182)2.18978834
115Craniofacial dystonia (HP:0012179)2.18694044
116Impaired vibratory sensation (HP:0002495)2.16794046
117Sclerocornea (HP:0000647)2.15988170
118Absent speech (HP:0001344)2.15746028
119Poor suck (HP:0002033)2.15288517
120Hemiplegia (HP:0002301)2.14791667
121Polyphagia (HP:0002591)2.13503945
122Diplopia (HP:0000651)2.12997683
123Abnormality of binocular vision (HP:0011514)2.12997683
124Status epilepticus (HP:0002133)2.09846382
125Renal Fanconi syndrome (HP:0001994)2.09105535
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08918457
127Tetany (HP:0001281)2.08174587
128Limb dystonia (HP:0002451)2.07835582
129Occipital encephalocele (HP:0002085)2.07544115
130Amyotrophic lateral sclerosis (HP:0007354)2.07031527
131Congenital sensorineural hearing impairment (HP:0008527)2.06176559
132EEG with generalized epileptiform discharges (HP:0011198)2.05308686
133Bulbous nose (HP:0000414)2.04851935
134Abnormality of the renal cortex (HP:0011035)2.04710187
135Papilledema (HP:0001085)2.04689960
136Neuronal loss in central nervous system (HP:0002529)2.04582616
137Abnormality of the nasal mucosa (HP:0000433)2.02183834
138Protruding tongue (HP:0010808)2.01099339
139Tubulointerstitial abnormality (HP:0001969)1.99783672
140Lower limb muscle weakness (HP:0007340)1.98674578
141Bronchiectasis (HP:0002110)1.97404365
142Iris hypopigmentation (HP:0007730)1.96574141
143Truncus arteriosus (HP:0001660)1.96478482
144Dysmetric saccades (HP:0000641)1.96076138
145Cystic liver disease (HP:0006706)1.93361498
146Abnormality of the pubic bones (HP:0003172)1.93253538
147Abnormal EKG (HP:0003115)1.92710245
148Photophobia (HP:0000613)1.91176750
149Unsteady gait (HP:0002317)1.91163804
150Glycosuria (HP:0003076)1.90234199
151Abnormality of urine glucose concentration (HP:0011016)1.90234199
152Abnormal ciliary motility (HP:0012262)1.90145751
153Anencephaly (HP:0002323)1.88764793
154Abnormal respiratory motile cilium physiology (HP:0012261)1.86882811
155Insomnia (HP:0100785)1.86650065
156Clonus (HP:0002169)1.84430878
157Generalized myoclonic seizures (HP:0002123)1.83956165
158Hypsarrhythmia (HP:0002521)1.83294862
159Congenital hepatic fibrosis (HP:0002612)1.82507546
160Gait imbalance (HP:0002141)1.82423733
161Incomplete penetrance (HP:0003829)1.81821277
162Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81233727
163Abnormality of the parathyroid morphology (HP:0011766)1.79006643
164Generalized hypopigmentation of hair (HP:0011358)1.78931305
165Pointed chin (HP:0000307)1.78890962
166Intention tremor (HP:0002080)1.78773794
167Type II diabetes mellitus (HP:0005978)1.78542419
168Tetraplegia (HP:0002445)1.77706271
169Rigidity (HP:0002063)1.77410181
170Abnormality of the costochondral junction (HP:0000919)1.76724284
171Severe visual impairment (HP:0001141)1.75878057
172Psychosis (HP:0000709)1.75068123
173Chronic bronchitis (HP:0004469)1.74983944
174Abnormality of renal resorption (HP:0011038)1.73772256
175Abnormality of the epiphysis of the femoral head (HP:0010574)1.73633913
176Truncal obesity (HP:0001956)1.73461356
177Gait ataxia (HP:0002066)1.73118283
178Limb ataxia (HP:0002070)1.73055494
179Hypophosphatemic rickets (HP:0004912)1.71938288
180Failure to thrive in infancy (HP:0001531)1.70471144
181Specific learning disability (HP:0001328)1.69999399
182Cerebral inclusion bodies (HP:0100314)1.69903565
183Male pseudohermaphroditism (HP:0000037)1.69709530
184Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69271520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.55099887
2EPHA45.42294418
3MAP4K24.39734488
4NTRK34.35780595
5TESK14.31850659
6DDR23.76672166
7MAP3K93.53251147
8TNIK3.28267386
9MAP3K122.84857594
10FRK2.68129514
11MAPK152.67572197
12MAP3K42.56204736
13MAP2K72.42608494
14MINK12.42170417
15RIPK42.30792533
16DAPK22.26946002
17KSR22.17886100
18MARK12.07957025
19PAK62.04979164
20STK38L2.03364895
21ARAF2.02106347
22DAPK11.96237519
23CAMKK11.88141744
24FES1.86758796
25WNK41.86434841
26PRKD31.83426833
27ADRBK21.74882953
28PRPF4B1.67722036
29MAP3K131.67141472
30ZAK1.66728008
31NTRK21.66291560
32PNCK1.65783970
33TNK21.65091558
34CDK191.62859933
35BRD41.62805979
36BMPR1B1.61282560
37MAP2K41.59889670
38CAMK1G1.56811315
39SIK21.50048567
40CASK1.44775239
41STK381.43780150
42WNK11.42885729
43KSR11.40551280
44CDK51.40005307
45GRK51.38828125
46WNK31.37555890
47MAPK131.30948612
48ACVR1B1.26789923
49CAMK11.26168572
50RAF11.23044009
51PINK11.17350968
52CAMKK21.17043686
53NTRK11.14742701
54TLK11.12299884
55STK391.10913209
56UHMK11.10493616
57NUAK11.05709981
58PRKCG1.05370914
59TAOK11.03428368
60MARK21.01375916
61PIK3CG0.99482836
62TYRO30.98337250
63STK160.93620552
64DYRK1B0.90528971
65CAMK2A0.89363378
66MUSK0.87291589
67STK110.84039711
68GRK10.83724516
69PRKD20.83175882
70DYRK20.81560458
71CDK70.80928966
72TXK0.79763967
73PLK20.78759040
74CDK180.78006640
75CDK150.77870991
76TAOK20.77285387
77CAMK2B0.75810250
78NME10.75018778
79PRKG10.74901344
80PRKCH0.74670366
81PTK2B0.73111583
82BRAF0.72399631
83CDK140.72120001
84CDK11A0.71191006
85INSRR0.67757468
86MAP3K10.67199693
87MST1R0.66467864
88CCNB10.65949827
89IRAK20.65282669
90DYRK1A0.65253329
91PDK10.64504502
92MAP3K60.64022246
93ALK0.62390363
94MAP3K20.62063251
95PDK30.61897947
96PDK40.61897947
97MAP3K70.61819316
98BMPR20.61252200
99PRKAA20.61005071
100RPS6KA20.60843872
101NEK60.60012644
102CAMK1D0.58511149
103MAP2K20.55806049
104AKT30.54406997
105TRIM280.54315745
106PRKCE0.53711862
107CSNK1G20.53352088
108RPS6KA10.53233707
109OXSR10.52705539
110MAP2K60.52420278
111SGK10.50480612
112PRKG20.50350522
113PDPK10.49695198
114CDK30.47742225
115DAPK30.47256929
116FGR0.47050490
117TAOK30.46656378
118PKN10.46458403
119ICK0.45016430
120VRK10.43562709
121MAPK100.43093971
122RPS6KA60.41434116
123PHKG10.41409946
124PHKG20.41409946
125ROCK10.40186751
126RPS6KA30.39714519
127CAMK40.38620182
128BRSK10.38240434
129CAMK2D0.38174413
130NEK20.37810052
131RET0.37767112
132LATS10.37265301
133ADRBK10.37006008
134PRKCQ0.36690234
135GSK3B0.36391238
136CAMK2G0.35560188
137IKBKB0.35151976
138PRKCZ0.33907256
139MAPK80.31544325
140MAPKAPK50.31158064
141SGK4940.29604418
142SGK2230.29604418
143MAPK10.28782357
144PAK30.28642380
145FYN0.27842955
146MAP3K110.27786892
147PRKCB0.27734694
148CDK10.27455646
149TIE10.27030942
150GRK70.26330442
151PRKCA0.25611262
152CDK20.25599427
153CSNK1A10.24913001
154RPS6KC10.24665707
155RPS6KL10.24665707
156PRKACA0.24252862
157BRSK20.24083733
158CSNK1E0.23918778
159DYRK30.23561609
160FER0.22980319

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.13395470
2Nicotine addiction_Homo sapiens_hsa050334.29173487
3Fatty acid biosynthesis_Homo sapiens_hsa000614.22159330
4Synaptic vesicle cycle_Homo sapiens_hsa047213.51264307
5Butanoate metabolism_Homo sapiens_hsa006503.23748885
6Olfactory transduction_Homo sapiens_hsa047403.00527107
7GABAergic synapse_Homo sapiens_hsa047272.87132457
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86356193
9Morphine addiction_Homo sapiens_hsa050322.84249866
10Circadian entrainment_Homo sapiens_hsa047132.83695737
11Long-term potentiation_Homo sapiens_hsa047202.81013768
12Amphetamine addiction_Homo sapiens_hsa050312.76013636
13Glutamatergic synapse_Homo sapiens_hsa047242.71125888
14Salivary secretion_Homo sapiens_hsa049702.21453852
15Dopaminergic synapse_Homo sapiens_hsa047282.20932415
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12545910
17Taste transduction_Homo sapiens_hsa047422.01463043
18Insulin secretion_Homo sapiens_hsa049112.00311734
19Cholinergic synapse_Homo sapiens_hsa047251.87312410
20Cocaine addiction_Homo sapiens_hsa050301.84506515
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83125021
22Calcium signaling pathway_Homo sapiens_hsa040201.78893207
23Oxytocin signaling pathway_Homo sapiens_hsa049211.75753785
24Selenocompound metabolism_Homo sapiens_hsa004501.73888310
25Serotonergic synapse_Homo sapiens_hsa047261.72925856
26Gastric acid secretion_Homo sapiens_hsa049711.72711968
27Collecting duct acid secretion_Homo sapiens_hsa049661.70541631
28Allograft rejection_Homo sapiens_hsa053301.70172383
29Renin secretion_Homo sapiens_hsa049241.67726463
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.67478672
31Long-term depression_Homo sapiens_hsa047301.64098994
32Autoimmune thyroid disease_Homo sapiens_hsa053201.61121079
33Nitrogen metabolism_Homo sapiens_hsa009101.54241459
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52409169
35Graft-versus-host disease_Homo sapiens_hsa053321.45966892
36GnRH signaling pathway_Homo sapiens_hsa049121.44338407
37Linoleic acid metabolism_Homo sapiens_hsa005911.34923071
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34532407
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33233379
40Basal transcription factors_Homo sapiens_hsa030221.33066892
41cAMP signaling pathway_Homo sapiens_hsa040241.32239615
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31611723
43Fatty acid degradation_Homo sapiens_hsa000711.28728326
44Gap junction_Homo sapiens_hsa045401.27504297
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27017044
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24186489
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23544931
48Cardiac muscle contraction_Homo sapiens_hsa042601.19331628
49Fatty acid metabolism_Homo sapiens_hsa012121.17631338
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16903806
51Arginine and proline metabolism_Homo sapiens_hsa003301.16026274
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12574681
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09323202
54Oocyte meiosis_Homo sapiens_hsa041141.09113436
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07441490
56ABC transporters_Homo sapiens_hsa020101.04098738
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03698961
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03656272
59Pancreatic secretion_Homo sapiens_hsa049720.99198400
60Estrogen signaling pathway_Homo sapiens_hsa049150.98125809
61Antigen processing and presentation_Homo sapiens_hsa046120.96695185
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93900749
63Hedgehog signaling pathway_Homo sapiens_hsa043400.93852658
64Phototransduction_Homo sapiens_hsa047440.92609657
65Glycerolipid metabolism_Homo sapiens_hsa005610.92004853
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91532063
67ErbB signaling pathway_Homo sapiens_hsa040120.91490035
68Glioma_Homo sapiens_hsa052140.91351443
69Fat digestion and absorption_Homo sapiens_hsa049750.91206029
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.90411442
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89772666
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.89645737
73Fanconi anemia pathway_Homo sapiens_hsa034600.88227935
74Vibrio cholerae infection_Homo sapiens_hsa051100.87871524
75Axon guidance_Homo sapiens_hsa043600.87858303
76RNA transport_Homo sapiens_hsa030130.87446045
77Retinol metabolism_Homo sapiens_hsa008300.86760422
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86434379
79Type II diabetes mellitus_Homo sapiens_hsa049300.86242682
80Tryptophan metabolism_Homo sapiens_hsa003800.84273803
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84248433
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83379843
83Melanogenesis_Homo sapiens_hsa049160.81765136
84Circadian rhythm_Homo sapiens_hsa047100.77877814
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.77858094
86Choline metabolism in cancer_Homo sapiens_hsa052310.77622852
87Purine metabolism_Homo sapiens_hsa002300.76485568
88Dorso-ventral axis formation_Homo sapiens_hsa043200.75533465
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.71693999
90Regulation of autophagy_Homo sapiens_hsa041400.71102618
91Alcoholism_Homo sapiens_hsa050340.70610935
92Phenylalanine metabolism_Homo sapiens_hsa003600.68986348
93MAPK signaling pathway_Homo sapiens_hsa040100.68361456
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.67136294
95Inositol phosphate metabolism_Homo sapiens_hsa005620.65592410
96Peroxisome_Homo sapiens_hsa041460.65551269
97Propanoate metabolism_Homo sapiens_hsa006400.63473480
98VEGF signaling pathway_Homo sapiens_hsa043700.63414312
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62287128
100Caffeine metabolism_Homo sapiens_hsa002320.61265064
101Ether lipid metabolism_Homo sapiens_hsa005650.60805447
102Arginine biosynthesis_Homo sapiens_hsa002200.60072092
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.58534146
104Chemical carcinogenesis_Homo sapiens_hsa052040.56463783
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55835107
106Type I diabetes mellitus_Homo sapiens_hsa049400.54003951
107Alzheimers disease_Homo sapiens_hsa050100.53357118
108Thyroid hormone synthesis_Homo sapiens_hsa049180.53195527
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53125494
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52348031
111Vitamin B6 metabolism_Homo sapiens_hsa007500.51840653
112Ras signaling pathway_Homo sapiens_hsa040140.51707581
113RNA polymerase_Homo sapiens_hsa030200.48815734
114Tyrosine metabolism_Homo sapiens_hsa003500.48695709
115Metabolic pathways_Homo sapiens_hsa011000.47908658
116Glucagon signaling pathway_Homo sapiens_hsa049220.47427413
117PPAR signaling pathway_Homo sapiens_hsa033200.47311322
118Protein digestion and absorption_Homo sapiens_hsa049740.44856856
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44777677
120Endocytosis_Homo sapiens_hsa041440.44664828
121Oxidative phosphorylation_Homo sapiens_hsa001900.44588910
122Viral myocarditis_Homo sapiens_hsa054160.44554825
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.44414698
124Rap1 signaling pathway_Homo sapiens_hsa040150.43787211
125Dilated cardiomyopathy_Homo sapiens_hsa054140.43630592
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43062019
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42276498
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41976352
129Parkinsons disease_Homo sapiens_hsa050120.41595077
130Homologous recombination_Homo sapiens_hsa034400.41265272
131mTOR signaling pathway_Homo sapiens_hsa041500.40883675
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40134633
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38921503
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38440485
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.37986864
136Non-small cell lung cancer_Homo sapiens_hsa052230.37732499
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36661476
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.35589324
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33904105
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33801910
141Mineral absorption_Homo sapiens_hsa049780.33794619
142Asthma_Homo sapiens_hsa053100.33597018
143Huntingtons disease_Homo sapiens_hsa050160.33474451
144beta-Alanine metabolism_Homo sapiens_hsa004100.32742101
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32607078
146Wnt signaling pathway_Homo sapiens_hsa043100.31687074
147T cell receptor signaling pathway_Homo sapiens_hsa046600.30423194
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29401478
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29202227
150Prion diseases_Homo sapiens_hsa050200.26522451
151Insulin signaling pathway_Homo sapiens_hsa049100.23538005
152Chemokine signaling pathway_Homo sapiens_hsa040620.23418662
153Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22880291
154Renal cell carcinoma_Homo sapiens_hsa052110.20592816

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