TMEM192

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.33281211
2DNA deamination (GO:0045006)5.58337919
3indole-containing compound catabolic process (GO:0042436)4.76111061
4indolalkylamine catabolic process (GO:0046218)4.76111061
5tryptophan catabolic process (GO:0006569)4.76111061
6L-fucose catabolic process (GO:0042355)4.73546801
7fucose catabolic process (GO:0019317)4.73546801
8L-fucose metabolic process (GO:0042354)4.73546801
9kynurenine metabolic process (GO:0070189)4.70183454
10ribosomal small subunit assembly (GO:0000028)4.63663939
11indolalkylamine metabolic process (GO:0006586)4.30869137
12cellular ketone body metabolic process (GO:0046950)4.17958350
13ribosomal small subunit biogenesis (GO:0042274)4.13494206
14viral transcription (GO:0019083)4.11818073
15translational termination (GO:0006415)4.01274765
16tryptophan metabolic process (GO:0006568)4.01000028
17formation of translation preinitiation complex (GO:0001731)3.94745239
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.91299233
19proteasome assembly (GO:0043248)3.88911739
20ketone body metabolic process (GO:1902224)3.81501397
21protein targeting to ER (GO:0045047)3.80996267
22cotranslational protein targeting to membrane (GO:0006613)3.79912602
23antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.76720024
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.72772886
25rRNA modification (GO:0000154)3.67147426
26protein localization to endoplasmic reticulum (GO:0070972)3.66470682
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.65807083
28translational elongation (GO:0006414)3.62635696
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.60797277
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.57283023
31translational initiation (GO:0006413)3.54708490
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50482729
33sulfation (GO:0051923)3.43180248
34maturation of SSU-rRNA (GO:0030490)3.41081985
35indole-containing compound metabolic process (GO:0042430)3.38396631
36cellular biogenic amine catabolic process (GO:0042402)3.37162038
37amine catabolic process (GO:0009310)3.37162038
38behavioral response to ethanol (GO:0048149)3.31992337
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31506815
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.29751861
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29666151
42translation (GO:0006412)3.26833683
43aromatic amino acid family catabolic process (GO:0009074)3.26792899
44oxidative demethylation (GO:0070989)3.26623530
45ribonucleoprotein complex biogenesis (GO:0022613)3.25234445
46pseudouridine synthesis (GO:0001522)3.24732048
47regulation of hippo signaling (GO:0035330)3.23890766
48regulation of cellular amino acid metabolic process (GO:0006521)3.22712286
49metallo-sulfur cluster assembly (GO:0031163)3.22174315
50iron-sulfur cluster assembly (GO:0016226)3.22174315
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21418325
52reflex (GO:0060004)3.20122211
53GDP-mannose metabolic process (GO:0019673)3.19921578
54detection of light stimulus involved in sensory perception (GO:0050962)3.18416950
55detection of light stimulus involved in visual perception (GO:0050908)3.18416950
56ribosomal large subunit biogenesis (GO:0042273)3.16461634
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16203650
58drug catabolic process (GO:0042737)3.15961398
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15366833
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15366833
61viral life cycle (GO:0019058)3.14288909
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13973154
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13973154
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13973154
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13891694
66exogenous drug catabolic process (GO:0042738)3.13391211
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13098959
68negative regulation of ligase activity (GO:0051352)3.13098959
69amino acid salvage (GO:0043102)3.12618040
70L-methionine salvage (GO:0071267)3.12618040
71L-methionine biosynthetic process (GO:0071265)3.12618040
72regulation of mitochondrial translation (GO:0070129)3.12025457
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11974332
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10298397
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.10298397
76response to pheromone (GO:0019236)3.09975455
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08306423
78NAD biosynthetic process (GO:0009435)3.07988853
79rRNA methylation (GO:0031167)3.05950713
80cellular protein complex disassembly (GO:0043624)3.04824625
81ribosome biogenesis (GO:0042254)3.02654023
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.01946831
83rRNA processing (GO:0006364)3.01659364
84piRNA metabolic process (GO:0034587)3.01309483
85negative regulation of telomere maintenance (GO:0032205)3.00411838
86antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.00158053
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.00096634
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00096634
89cellular response to ATP (GO:0071318)2.98901373
90water-soluble vitamin biosynthetic process (GO:0042364)2.97422344
91immunoglobulin mediated immune response (GO:0016064)2.97307291
92nonmotile primary cilium assembly (GO:0035058)2.94773653
93negative regulation of mast cell activation (GO:0033004)2.94230274
94neuronal action potential (GO:0019228)2.94219659
95primary amino compound metabolic process (GO:1901160)2.89860612
96neural tube formation (GO:0001841)2.89496833
97rRNA metabolic process (GO:0016072)2.88790855
98gamma-aminobutyric acid transport (GO:0015812)2.88446635
99sphingoid metabolic process (GO:0046519)2.88341709
100ribosome assembly (GO:0042255)2.88062460
101positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87569816
102serotonin metabolic process (GO:0042428)2.84229362
103nucleobase-containing small molecule interconversion (GO:0015949)2.83586107
104DNA methylation involved in gamete generation (GO:0043046)2.82765416
105positive regulation of ligase activity (GO:0051351)2.81043126
106neutrophil activation involved in immune response (GO:0002283)2.80334022
107platelet dense granule organization (GO:0060155)2.77944886
108response to interferon-beta (GO:0035456)2.77276191
109antigen processing and presentation via MHC class Ib (GO:0002475)2.76481718
110respiratory burst (GO:0045730)2.75407985
111kidney morphogenesis (GO:0060993)2.74821737
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74768302
113benzene-containing compound metabolic process (GO:0042537)2.73558591
114folic acid metabolic process (GO:0046655)2.73489795
115signal peptide processing (GO:0006465)2.73427030
116regulation of pigment cell differentiation (GO:0050932)2.73140495
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72997750
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.72997750
119NADH dehydrogenase complex assembly (GO:0010257)2.72997750
120aromatic amino acid family metabolic process (GO:0009072)2.71875942
121B cell mediated immunity (GO:0019724)2.71469987
122endosome to pigment granule transport (GO:0043485)2.71323240
123endosome to melanosome transport (GO:0035646)2.71323240
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.71246560
125reciprocal meiotic recombination (GO:0007131)2.70879393
126reciprocal DNA recombination (GO:0035825)2.70879393
127positive regulation of developmental pigmentation (GO:0048087)2.69287339
128cornea development in camera-type eye (GO:0061303)2.66914881
129negative regulation of reactive oxygen species metabolic process (GO:2000378)2.66698014
130pteridine-containing compound biosynthetic process (GO:0042559)2.65655466
131cellular component biogenesis (GO:0044085)2.64993127
132ubiquinone biosynthetic process (GO:0006744)2.64830588
133neurotransmitter metabolic process (GO:0042133)2.63956782
134preassembly of GPI anchor in ER membrane (GO:0016254)2.63491611
135positive regulation of cell cycle arrest (GO:0071158)2.62609073
136positive regulation of fatty acid oxidation (GO:0046321)2.61587697
137regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61437665
138telomere maintenance via semi-conservative replication (GO:0032201)2.60714578
139positive regulation of fatty acid transport (GO:2000193)2.59772216
140DNA strand elongation involved in DNA replication (GO:0006271)2.59767502
141regulation of nuclear cell cycle DNA replication (GO:0033262)2.59597841
142spinal cord motor neuron differentiation (GO:0021522)2.59406788
143synaptic transmission, cholinergic (GO:0007271)2.59051527
144protein import into peroxisome matrix (GO:0016558)2.58445037
145S-adenosylmethionine metabolic process (GO:0046500)2.57530351
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57329289
147rhodopsin mediated signaling pathway (GO:0016056)2.56942287
148protein targeting to membrane (GO:0006612)2.56884989
149establishment of protein localization to mitochondrion (GO:0072655)2.56759905
150protein targeting to mitochondrion (GO:0006626)2.56741723
151protein complex disassembly (GO:0043241)2.55751835
152antigen processing and presentation of endogenous antigen (GO:0019883)2.55199942
153methionine biosynthetic process (GO:0009086)2.54570261
154purine nucleobase biosynthetic process (GO:0009113)2.54291064
155fucosylation (GO:0036065)2.53478203
156flavonoid metabolic process (GO:0009812)2.53161844
157peristalsis (GO:0030432)2.53103376
158purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.52397893
1593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.52397893
160protein complex biogenesis (GO:0070271)2.52362830
161sulfate transmembrane transport (GO:1902358)2.51993642
162cellular response to interferon-beta (GO:0035458)2.51935375
163nephron epithelium morphogenesis (GO:0072088)2.51765533
164nephron tubule morphogenesis (GO:0072078)2.51765533
165termination of RNA polymerase III transcription (GO:0006386)2.51447510
166transcription elongation from RNA polymerase III promoter (GO:0006385)2.51447510
167auditory receptor cell stereocilium organization (GO:0060088)2.50501191
168response to peptidoglycan (GO:0032494)2.49859829
169epithelial cilium movement (GO:0003351)2.49621989
170negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49392588
171negative regulation of translation, ncRNA-mediated (GO:0040033)2.49392588
172regulation of translation, ncRNA-mediated (GO:0045974)2.49392588
173photoreceptor cell maintenance (GO:0045494)2.49328398
174ubiquinone metabolic process (GO:0006743)2.49272713
175cilium morphogenesis (GO:0060271)2.48355588
176negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47852807
177sequestering of actin monomers (GO:0042989)2.47622438
178respiratory chain complex IV assembly (GO:0008535)2.46983439
179DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.46310332
180nucleobase biosynthetic process (GO:0046112)2.46252659
181negative regulation of systemic arterial blood pressure (GO:0003085)2.46078058
182deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45835957
183membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45196647
184somite rostral/caudal axis specification (GO:0032525)2.44995306
185folic acid-containing compound biosynthetic process (GO:0009396)2.42915004
186macromolecular complex disassembly (GO:0032984)2.42645874
187DNA strand elongation (GO:0022616)2.41074723
188type I interferon signaling pathway (GO:0060337)2.40684339
189cellular response to type I interferon (GO:0071357)2.40684339
190regulation of ubiquitin-protein transferase activity (GO:0051438)2.40216932
191mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39747985
192nuclear-transcribed mRNA catabolic process (GO:0000956)2.39055247
193DNA replication initiation (GO:0006270)2.38553668
194cellular response to zinc ion (GO:0071294)2.37677929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.93498131
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71776788
3VDR_22108803_ChIP-Seq_LS180_Human3.51017699
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.31312429
5EZH2_22144423_ChIP-Seq_EOC_Human3.19686206
6GBX2_23144817_ChIP-Seq_PC3_Human3.15149336
7E2F7_22180533_ChIP-Seq_HELA_Human3.02952425
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98183257
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.96145620
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.93735798
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71887315
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70555843
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.66706195
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.60172024
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58375652
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57659288
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.56663694
18IGF1R_20145208_ChIP-Seq_DFB_Human2.49428228
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46642143
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39860450
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.38330754
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33635300
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27759969
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19460211
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18503404
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16277176
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15656121
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15065616
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14052281
30* VDR_23849224_ChIP-Seq_CD4+_Human2.09007099
31ER_23166858_ChIP-Seq_MCF-7_Human2.08294505
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.07971331
33CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06258599
34TAF15_26573619_Chip-Seq_HEK293_Human1.96386741
35EWS_26573619_Chip-Seq_HEK293_Human1.95266552
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94825212
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92224543
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90622872
39* P300_19829295_ChIP-Seq_ESCs_Human1.88923536
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88476783
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87778341
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82415370
43DCP1A_22483619_ChIP-Seq_HELA_Human1.80938832
44XRN2_22483619_ChIP-Seq_HELA_Human1.79235534
45FUS_26573619_Chip-Seq_HEK293_Human1.78447515
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77881724
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77367748
48* GABP_19822575_ChIP-Seq_HepG2_Human1.76495046
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74114940
50STAT3_23295773_ChIP-Seq_U87_Human1.72454415
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71023518
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.70569307
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69717719
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69574587
55AR_21572438_ChIP-Seq_LNCaP_Human1.67604723
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66569626
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65138191
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.64565881
59* SPI1_23547873_ChIP-Seq_NB4_Human1.64405788
60FOXP3_21729870_ChIP-Seq_TREG_Human1.64314688
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.64047470
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60933617
63MYC_22102868_ChIP-Seq_BL_Human1.59622049
64TCF4_23295773_ChIP-Seq_U87_Human1.57621131
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57255915
66TFEB_21752829_ChIP-Seq_HELA_Human1.56091667
67REST_21632747_ChIP-Seq_MESCs_Mouse1.56090713
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55899599
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55804716
70VDR_21846776_ChIP-Seq_THP-1_Human1.53881095
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53548646
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53383158
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53308837
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53308837
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52966972
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52302394
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52013699
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.51541963
79BCAT_22108803_ChIP-Seq_LS180_Human1.50473970
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49875764
81AR_25329375_ChIP-Seq_VCAP_Human1.49228865
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49119564
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46737490
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.46180676
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45929277
86CBP_20019798_ChIP-Seq_JUKART_Human1.45929277
87SMAD4_21799915_ChIP-Seq_A2780_Human1.45186223
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44994029
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44456869
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42885427
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42469469
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41971360
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41605339
94* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40800266
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39786169
96TP53_22573176_ChIP-Seq_HFKS_Human1.39424232
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39097496
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39077607
99SOX2_19829295_ChIP-Seq_ESCs_Human1.37983590
100NANOG_19829295_ChIP-Seq_ESCs_Human1.37983590
101TTF2_22483619_ChIP-Seq_HELA_Human1.36834766
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.36109651
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35914619
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35684243
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35341709
106POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35333811
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34799940
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32327323
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32254495
110TCF4_22108803_ChIP-Seq_LS180_Human1.32161778
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31281217
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.31033129
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31033129
114E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30589679
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30461079
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28069829
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27853949
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.27639419
119HOXB7_26014856_ChIP-Seq_BT474_Human1.25450969
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22568685
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21868470
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21851773
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21733632
124NOTCH1_21737748_ChIP-Seq_TLL_Human1.21686768
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.21066471
126IRF1_19129219_ChIP-ChIP_H3396_Human1.21019469
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20771186
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19477769
129PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18847090
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.18832540
131RUNX2_22187159_ChIP-Seq_PCA_Human1.18442480
132KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18413264
133TP53_16413492_ChIP-PET_HCT116_Human1.18368146
134ELK1_19687146_ChIP-ChIP_HELA_Human1.18307244
135ELK1_22589737_ChIP-Seq_MCF10A_Human1.17791653
136FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17383048
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.16773082
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16732011
139* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15881054
140SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15488287
141ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14707251
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12633656
143KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12312080
144RNF2_27304074_Chip-Seq_NSC_Mouse1.12234667
145MAF_26560356_Chip-Seq_TH1_Human1.12220605
146NCOR_22424771_ChIP-Seq_293T_Human1.11964734
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11871346
148IRF8_27001747_Chip-Seq_BMDM_Mouse1.11471263
149CIITA_25753668_ChIP-Seq_RAJI_Human1.11231784
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11078190
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10742766
152RUNX1_22412390_ChIP-Seq_EML_Mouse1.10629683
153PRDM14_20953172_ChIP-Seq_ESCs_Human1.10531468
154EZH2_27294783_Chip-Seq_NPCs_Mouse1.10157184
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09851222
156KDM5A_27292631_Chip-Seq_BREAST_Human1.09640205
157MYB_26560356_Chip-Seq_TH2_Human1.09427283
158POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08935866
159AR_20517297_ChIP-Seq_VCAP_Human1.08583416
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08374915
161* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08149168
162EGR1_19374776_ChIP-ChIP_THP-1_Human1.07419947
163DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07294498
164NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06979418
165GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06489547
166MYC_18940864_ChIP-ChIP_HL60_Human1.05147006
167CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04936928
168ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04004017
169MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03840982
170* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03624254
171MYB_26560356_Chip-Seq_TH1_Human1.03298188
172MAF_26560356_Chip-Seq_TH2_Human1.03148215
173MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03006997
174BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02294465
175SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02016613
176TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01538048
177TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01506720
178DROSHA_22980978_ChIP-Seq_HELA_Human1.01491146
179CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01329760
180CRX_20693478_ChIP-Seq_RETINA_Mouse1.00357536
181VDR_24763502_ChIP-Seq_THP-1_Human1.00337784
182BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00045238
183NANOG_18555785_Chip-Seq_ESCs_Mouse0.99414601
184EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99184786
185* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98705531
186TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98476104
187ERA_21632823_ChIP-Seq_H3396_Human0.98062615
188P53_22387025_ChIP-Seq_ESCs_Mouse0.97827382
189SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97717890
190MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97406876
191CDX2_22108803_ChIP-Seq_LS180_Human0.97183668
192PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96865519
193GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96678618
194SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96360088
195EZH2_27304074_Chip-Seq_ESCs_Mouse0.95064846
196EED_16625203_ChIP-ChIP_MESCs_Mouse0.94699220
197JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94036909
198STAT3_18555785_Chip-Seq_ESCs_Mouse0.93798244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.50747670
2MP0001835_abnormal_antigen_presentation3.36177574
3MP0009840_abnormal_foam_cell3.34028030
4MP0005058_abnormal_lysosome_morphology3.11323854
5MP0003693_abnormal_embryo_hatching3.07419221
6MP0003136_yellow_coat_color3.01388921
7MP0002837_dystrophic_cardiac_calcinosis2.98815557
8MP0003646_muscle_fatigue2.94183791
9MP0006082_CNS_inflammation2.68382886
10MP0009785_altered_susceptibility_to2.62584976
11MP0009333_abnormal_splenocyte_physiolog2.60189654
12MP0009046_muscle_twitch2.57291672
13MP0008875_abnormal_xenobiotic_pharmacok2.54659917
14MP0005671_abnormal_response_to2.53252588
15MP0003186_abnormal_redox_activity2.49805060
16MP0000685_abnormal_immune_system2.47931026
17MP0004957_abnormal_blastocyst_morpholog2.46361205
18MP0005000_abnormal_immune_tolerance2.44947712
19MP0005551_abnormal_eye_electrophysiolog2.35775401
20MP0003436_decreased_susceptibility_to2.33259469
21MP0005025_abnormal_response_to2.29322417
22MP0001790_abnormal_immune_system2.26622319
23MP0005387_immune_system_phenotype2.26622319
24MP0001968_abnormal_touch/_nociception2.21278767
25MP0003890_abnormal_embryonic-extraembry2.15772221
26MP0002723_abnormal_immune_serum2.13869343
27MP0002148_abnormal_hypersensitivity_rea2.12770870
28MP0001800_abnormal_humoral_immune2.10995757
29MP0002102_abnormal_ear_morphology2.10477727
30MP0003806_abnormal_nucleotide_metabolis2.09326314
31MP0002452_abnormal_antigen_presenting2.05034593
32MP0001853_heart_inflammation2.03807329
33MP0002876_abnormal_thyroid_physiology2.02382990
34MP0004142_abnormal_muscle_tone2.00700019
35MP0002653_abnormal_ependyma_morphology2.00392169
36MP0000427_abnormal_hair_cycle1.97668776
37MP0002419_abnormal_innate_immunity1.97037029
38MP0001819_abnormal_immune_cell1.93314144
39MP0002420_abnormal_adaptive_immunity1.92823864
40MP0005085_abnormal_gallbladder_physiolo1.92659003
41MP0009745_abnormal_behavioral_response1.90486085
42MP0004147_increased_porphyrin_level1.88194044
43MP0008872_abnormal_physiological_respon1.86055320
44MP0002938_white_spotting1.84624266
45MP0003111_abnormal_nucleus_morphology1.84091641
46MP0000490_abnormal_crypts_of1.82223123
47MP0006072_abnormal_retinal_apoptosis1.80670002
48MP0002398_abnormal_bone_marrow1.76203799
49MP0002405_respiratory_system_inflammati1.73796850
50MP0001501_abnormal_sleep_pattern1.73483132
51MP0003763_abnormal_thymus_physiology1.71858157
52MP0000716_abnormal_immune_system1.70017978
53MP0002396_abnormal_hematopoietic_system1.69419909
54MP0008877_abnormal_DNA_methylation1.68670869
55MP0004885_abnormal_endolymph1.68042236
56MP0000689_abnormal_spleen_morphology1.68025089
57MP0002735_abnormal_chemical_nociception1.67445130
58MP0005646_abnormal_pituitary_gland1.66601700
59MP0005171_absent_coat_pigmentation1.65214036
60MP0005310_abnormal_salivary_gland1.64772524
61MP0002722_abnormal_immune_system1.63713802
62MP0005253_abnormal_eye_physiology1.62179732
63MP0005645_abnormal_hypothalamus_physiol1.61989693
64MP0002272_abnormal_nervous_system1.59002716
65MP0001845_abnormal_inflammatory_respons1.58740199
66MP0000858_altered_metastatic_potential1.56761023
67MP0003077_abnormal_cell_cycle1.56502689
68MP0002429_abnormal_blood_cell1.54089102
69MP0008469_abnormal_protein_level1.53609685
70MP0010155_abnormal_intestine_physiology1.52613155
71MP0004133_heterotaxia1.51334236
72MP0002736_abnormal_nociception_after1.51188881
73MP0000383_abnormal_hair_follicle1.48688223
74MP0003724_increased_susceptibility_to1.48459728
75MP0005464_abnormal_platelet_physiology1.47746505
76MP0002064_seizures1.47495685
77MP0004742_abnormal_vestibular_system1.47178917
78MP0001485_abnormal_pinna_reflex1.46137173
79MP0002572_abnormal_emotion/affect_behav1.44560581
80MP0004947_skin_inflammation1.44185261
81MP0005365_abnormal_bile_salt1.43776828
82MP0006036_abnormal_mitochondrial_physio1.40411957
83MP0003011_delayed_dark_adaptation1.39991318
84MP0000343_altered_response_to1.39307181
85MP0006276_abnormal_autonomic_nervous1.38445492
86MP0003045_fibrosis1.36414202
87MP0003303_peritoneal_inflammation1.35061853
88MP0003252_abnormal_bile_duct1.34749051
89MP0001486_abnormal_startle_reflex1.34590660
90MP0010094_abnormal_chromosome_stability1.33677751
91MP0002166_altered_tumor_susceptibility1.32962884
92MP0004924_abnormal_behavior1.29654273
93MP0005386_behavior/neurological_phenoty1.29654273
94MP0001545_abnormal_hematopoietic_system1.28849710
95MP0005397_hematopoietic_system_phenotyp1.28849710
96MP0002095_abnormal_skin_pigmentation1.27968661
97MP0003172_abnormal_lysosome_physiology1.27224394
98MP0004145_abnormal_muscle_electrophysio1.27005675
99MP0002067_abnormal_sensory_capabilities1.24465534
100MP0001970_abnormal_pain_threshold1.23177814
101MP0002019_abnormal_tumor_incidence1.22019309
102MP0010386_abnormal_urinary_bladder1.21877275
103MP0010352_gastrointestinal_tract_polyps1.21301868
104MP0002733_abnormal_thermal_nociception1.21202976
105MP0003283_abnormal_digestive_organ1.20920911
106MP0001533_abnormal_skeleton_physiology1.20786108
107MP0003191_abnormal_cellular_cholesterol1.20660634
108MP0000358_abnormal_cell_content/1.20316007
109MP0003195_calcinosis1.20019111
110MP0008932_abnormal_embryonic_tissue1.19381870
111MP0002006_tumorigenesis1.19348634
112MP0002928_abnormal_bile_duct1.16298407
113MP0000631_abnormal_neuroendocrine_gland1.14800231
114MP0002557_abnormal_social/conspecific_i1.14141015
115MP0003448_altered_tumor_morphology1.13176657
116MP0004130_abnormal_muscle_cell1.12421174
117MP0002160_abnormal_reproductive_system1.12130200
118MP0000703_abnormal_thymus_morphology1.11882855
119MP0003787_abnormal_imprinting1.11700337
120MP0001324_abnormal_eye_pigmentation1.11689189
121MP0000538_abnormal_urinary_bladder1.11031595
122MP0010329_abnormal_lipoprotein_level1.10727372
123MP0002933_joint_inflammation1.10579123
124MP0008058_abnormal_DNA_repair1.10351171
125MP0003866_abnormal_defecation1.09192446
126MP0000313_abnormal_cell_death1.07499630
127MP0002234_abnormal_pharynx_morphology1.07477323
128MP0002132_abnormal_respiratory_system1.06906637
129MP0008057_abnormal_DNA_replication1.05133299
130MP0005389_reproductive_system_phenotype1.04410531
131MP0008961_abnormal_basal_metabolism1.03272230
132MP0004510_myositis1.02684347
133MP0002063_abnormal_learning/memory/cond1.02474565
134MP0008260_abnormal_autophagy1.02024947
135MP0009643_abnormal_urine_homeostasis1.01279500
136MP0003656_abnormal_erythrocyte_physiolo1.00945151
137MP0010307_abnormal_tumor_latency1.00287754
138MP0005332_abnormal_amino_acid1.00220801
139MP0005195_abnormal_posterior_eye1.00144390
140MP0000015_abnormal_ear_pigmentation0.99843971
141MP0002138_abnormal_hepatobiliary_system0.99233690
142MP0005167_abnormal_blood-brain_barrier0.98006274
143MP0001764_abnormal_homeostasis0.97696308
144MP0001440_abnormal_grooming_behavior0.97333556
145MP0003635_abnormal_synaptic_transmissio0.96761321
146MP0003880_abnormal_central_pattern0.96316003
147MP0003137_abnormal_impulse_conducting0.96270605
148MP0001984_abnormal_olfaction0.95811310
149MP0005319_abnormal_enzyme/_coenzyme0.95187720
150MP0001905_abnormal_dopamine_level0.93688863
151MP0000609_abnormal_liver_physiology0.93372745
152MP0001873_stomach_inflammation0.91865467
153MP0005410_abnormal_fertilization0.91337999
154MP0003221_abnormal_cardiomyocyte_apopto0.89990026
155MP0003718_maternal_effect0.89401737
156MP0005084_abnormal_gallbladder_morpholo0.88180693
157MP0000230_abnormal_systemic_arterial0.87842384
158MP0002877_abnormal_melanocyte_morpholog0.87576637
159MP0005174_abnormal_tail_pigmentation0.87477727
160MP0000598_abnormal_liver_morphology0.86939383
161MP0008007_abnormal_cellular_replicative0.86149231
162MP0006292_abnormal_olfactory_placode0.85890738
163MP0005075_abnormal_melanosome_morpholog0.84877260
164MP0005448_abnormal_energy_balance0.83952275
165MP0002229_neurodegeneration0.83349876
166MP0000750_abnormal_muscle_regeneration0.82088225
167MP0001919_abnormal_reproductive_system0.81225727
168MP0008775_abnormal_heart_ventricle0.80034112
169MP0001502_abnormal_circadian_rhythm0.79560949
170MP0005423_abnormal_somatic_nervous0.79077965
171MP0006035_abnormal_mitochondrial_morpho0.78663914
172MP0001986_abnormal_taste_sensitivity0.77631737
173MP0003878_abnormal_ear_physiology0.76831803
174MP0005377_hearing/vestibular/ear_phenot0.76831803
175MP0002752_abnormal_somatic_nervous0.76404886
176MP0005670_abnormal_white_adipose0.76374651
177MP0004808_abnormal_hematopoietic_stem0.76276249
178MP0000372_irregular_coat_pigmentation0.76228629
179MP0005083_abnormal_biliary_tract0.75838528
180MP0003950_abnormal_plasma_membrane0.75449060
181MP0002693_abnormal_pancreas_physiology0.75007699
182MP0005584_abnormal_enzyme/coenzyme_acti0.74109109
183MP0004043_abnormal_pH_regulation0.73712575
184MP0000604_amyloidosis0.73416335
185MP0001730_embryonic_growth_arrest0.72952132
186MP0002136_abnormal_kidney_physiology0.72652947
187MP0000470_abnormal_stomach_morphology0.71994904
188MP0002638_abnormal_pupillary_reflex0.71601029
189MP0005023_abnormal_wound_healing0.70944080
190MP0009763_increased_sensitivity_to0.70614851
191MP0005636_abnormal_mineral_homeostasis0.70488579

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.77977147
2Abnormality of cells of the erythroid lineage (HP:0012130)4.18620885
3Molar tooth sign on MRI (HP:0002419)4.18267431
4Abnormality of midbrain morphology (HP:0002418)4.18267431
5Vacuolated lymphocytes (HP:0001922)4.12920723
6Hyperventilation (HP:0002883)4.03563445
7Pancreatic fibrosis (HP:0100732)3.99684468
8Abnormal number of erythroid precursors (HP:0012131)3.99360909
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.95989405
10Abnormality of alanine metabolism (HP:0010916)3.95989405
11Hyperalaninemia (HP:0003348)3.95989405
12Congenital stationary night blindness (HP:0007642)3.95228820
13Nephronophthisis (HP:0000090)3.87186378
14Elevated erythrocyte sedimentation rate (HP:0003565)3.84756038
15True hermaphroditism (HP:0010459)3.69711232
16Abnormality of the renal cortex (HP:0011035)3.64709271
17Abnormality of the renal medulla (HP:0100957)3.55097010
18Recurrent abscess formation (HP:0002722)3.48219286
19Type II lissencephaly (HP:0007260)3.38872299
20Abnormality of macrophages (HP:0004311)3.32459684
21Petechiae (HP:0000967)3.22496243
22Poor head control (HP:0002421)3.18571361
23IgM deficiency (HP:0002850)3.17149060
24Tubular atrophy (HP:0000092)3.16776341
25Eczematoid dermatitis (HP:0000976)3.13957374
26Attenuation of retinal blood vessels (HP:0007843)3.13820226
27Pustule (HP:0200039)3.12534983
28Multiple enchondromatosis (HP:0005701)3.07820438
29Abnormality of T cell physiology (HP:0011840)3.04921831
30Abnormality of liposaccharide metabolism (HP:0010968)3.02467715
31Abnormality of glycosphingolipid metabolism (HP:0004343)3.02467715
32Abnormality of glycolipid metabolism (HP:0010969)3.02467715
33Reticulocytopenia (HP:0001896)3.00976996
34Genetic anticipation (HP:0003743)2.99250371
35Inability to walk (HP:0002540)2.95692926
36Medial flaring of the eyebrow (HP:0010747)2.93624715
37Large for gestational age (HP:0001520)2.93073921
38Cystic liver disease (HP:0006706)2.89930729
39Recurrent bacterial skin infections (HP:0005406)2.89338114
40Dysostosis multiplex (HP:0000943)2.87705366
41Protruding tongue (HP:0010808)2.87169224
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.85071095
43Decreased circulating renin level (HP:0003351)2.80480794
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.77977622
45Microretrognathia (HP:0000308)2.77749352
46Increased cerebral lipofuscin (HP:0011813)2.76607608
47Cerebellar dysplasia (HP:0007033)2.74896924
48Chronic hepatic failure (HP:0100626)2.74195431
49Clumsiness (HP:0002312)2.73529104
50Gaze-evoked nystagmus (HP:0000640)2.72681408
51Progressive inability to walk (HP:0002505)2.71669928
52Progressive cerebellar ataxia (HP:0002073)2.69707509
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67020120
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66185274
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66185274
56Concave nail (HP:0001598)2.65284731
57Abnormal drinking behavior (HP:0030082)2.64789594
58Polydipsia (HP:0001959)2.64789594
59Abolished electroretinogram (ERG) (HP:0000550)2.60635348
60Increased hepatocellular lipid droplets (HP:0006565)2.57425129
61Abnormality of T cells (HP:0002843)2.56603877
62Amelogenesis imperfecta (HP:0000705)2.56245169
63Progressive muscle weakness (HP:0003323)2.54787248
64Fair hair (HP:0002286)2.53205158
65Pallor (HP:0000980)2.53069772
66Furrowed tongue (HP:0000221)2.52819316
67Congenital, generalized hypertrichosis (HP:0004540)2.51150965
68Recurrent fungal infections (HP:0002841)2.50676411
69Pendular nystagmus (HP:0012043)2.49798696
70Gait imbalance (HP:0002141)2.48461015
71Hepatic necrosis (HP:0002605)2.45725014
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.44599218
73Exertional dyspnea (HP:0002875)2.42951224
74Chronic otitis media (HP:0000389)2.42012072
75Mitochondrial inheritance (HP:0001427)2.41639218
76Abnormality of the pons (HP:0007361)2.41209153
77Focal motor seizures (HP:0011153)2.39720112
78Rough bone trabeculation (HP:0100670)2.39607144
79Thrombocytosis (HP:0001894)2.39263833
80Hepatocellular necrosis (HP:0001404)2.38813861
81Increased serum ferritin (HP:0003281)2.37300207
82Congenital primary aphakia (HP:0007707)2.37256872
83Decreased central vision (HP:0007663)2.36056923
84Increased intramyocellular lipid droplets (HP:0012240)2.34651488
85Patellar aplasia (HP:0006443)2.34089021
86Lissencephaly (HP:0001339)2.33713461
87Lipid accumulation in hepatocytes (HP:0006561)2.33537587
88Basal ganglia calcification (HP:0002135)2.32174998
89IgG deficiency (HP:0004315)2.31326081
90Macrocytic anemia (HP:0001972)2.31314534
91Progressive neurologic deterioration (HP:0002344)2.30502536
92Keratoconus (HP:0000563)2.30429105
93Increased corneal curvature (HP:0100692)2.30429105
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29752432
95Oral leukoplakia (HP:0002745)2.29739728
96Broad-based gait (HP:0002136)2.29488821
97Hypoplasia of the pons (HP:0012110)2.29178599
98Cerebral hypomyelination (HP:0006808)2.27211696
99Renal cortical cysts (HP:0000803)2.27202850
100Chronic mucocutaneous candidiasis (HP:0002728)2.26416114
101Recurrent cutaneous fungal infections (HP:0011370)2.26416114
102Recurrent skin infections (HP:0001581)2.25938728
103Autoimmune thrombocytopenia (HP:0001973)2.24681706
104Recurrent viral infections (HP:0004429)2.24362216
105Birth length less than 3rd percentile (HP:0003561)2.24072696
106Axonal loss (HP:0003447)2.24070639
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23985869
108Increased CSF lactate (HP:0002490)2.23184958
109Nephrogenic diabetes insipidus (HP:0009806)2.22665367
110Aplasia/Hypoplasia of the patella (HP:0006498)2.22572463
111Aplastic anemia (HP:0001915)2.22520444
112Poikiloderma (HP:0001029)2.21105946
113Congenital hepatic fibrosis (HP:0002612)2.20977685
114Abnormal mitochondria in muscle tissue (HP:0008316)2.20331051
115Bile duct proliferation (HP:0001408)2.19902065
116Abnormal biliary tract physiology (HP:0012439)2.19902065
117Acute necrotizing encephalopathy (HP:0006965)2.19741788
118Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19440336
119Prolonged neonatal jaundice (HP:0006579)2.18738230
120Sclerocornea (HP:0000647)2.18543592
121Nausea (HP:0002018)2.18488208
122Type I transferrin isoform profile (HP:0003642)2.18260171
123Increased muscle lipid content (HP:0009058)2.18241004
124Hyperglycinuria (HP:0003108)2.18235197
125Trismus (HP:0000211)2.18197499
126Polyuria (HP:0000103)2.18124418
127Increased IgM level (HP:0003496)2.17866099
128Severe muscular hypotonia (HP:0006829)2.16953722
129Reduced antithrombin III activity (HP:0001976)2.16604501
130Acute encephalopathy (HP:0006846)2.14386153
131Dynein arm defect of respiratory motile cilia (HP:0012255)2.12678474
132Absent/shortened dynein arms (HP:0200106)2.12678474
1333-Methylglutaconic aciduria (HP:0003535)2.12675905
134Generalized hypopigmentation of hair (HP:0011358)2.11245779
135Chronic obstructive pulmonary disease (HP:0006510)2.10711032
136Obstructive lung disease (HP:0006536)2.10711032
137Increased serum lactate (HP:0002151)2.10489239
138Dialeptic seizures (HP:0011146)2.10236820
139Abnormal rod and cone electroretinograms (HP:0008323)2.09984678
140Recurrent bronchitis (HP:0002837)2.08775443
141Myositis (HP:0100614)2.08414629
142Entropion (HP:0000621)2.07908873
143Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06614239
144Mucopolysacchariduria (HP:0008155)2.05551972
145Urinary glycosaminoglycan excretion (HP:0003541)2.05551972
146Agnosia (HP:0010524)2.04836447
147Lymphopenia (HP:0001888)2.04396199
148Recurrent gram-negative bacterial infections (HP:0005420)2.04134390
149Personality changes (HP:0000751)2.02778974
150Ketoacidosis (HP:0001993)2.02241061
151CNS demyelination (HP:0007305)2.02179966
152Chorioretinal atrophy (HP:0000533)2.02075065
153Abnormality of cells of the lymphoid lineage (HP:0012140)2.00884263
154Bony spicule pigmentary retinopathy (HP:0007737)1.98453685
155Renal Fanconi syndrome (HP:0001994)1.96900374
156Anencephaly (HP:0002323)1.95877283
157Ketosis (HP:0001946)1.93773421
158Combined immunodeficiency (HP:0005387)1.92752648
159Abnormal trabecular bone morphology (HP:0100671)1.92726757
160Hepatosplenomegaly (HP:0001433)1.92676511
161Cheilitis (HP:0100825)1.92508749
162Purpura (HP:0000979)1.91540125
163Genital tract atresia (HP:0001827)1.90318849
164Vaginal atresia (HP:0000148)1.89855443
165Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89764450
166Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89764450
167Abnormality of polysaccharide metabolism (HP:0011012)1.89764450
168Hypoplasia of the thymus (HP:0000778)1.89748467
169Nasal polyposis (HP:0100582)1.89673198
170Abnormality of the anterior horn cell (HP:0006802)1.89135121
171Degeneration of anterior horn cells (HP:0002398)1.89135121
172Tachypnea (HP:0002789)1.88939291
173Breast hypoplasia (HP:0003187)1.88645481
174Vertebral compression fractures (HP:0002953)1.87538065
175Focal seizures (HP:0007359)1.87024186
176Febrile seizures (HP:0002373)1.85664391
177Aplasia/Hypoplasia of the tongue (HP:0010295)1.82740549
178Male pseudohermaphroditism (HP:0000037)1.82073502
179Congenital sensorineural hearing impairment (HP:0008527)1.82017280
180Widely spaced teeth (HP:0000687)1.81697989
181Hemiparesis (HP:0001269)1.81160492
182Poor coordination (HP:0002370)1.80271115
183Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79371554
184Absent speech (HP:0001344)1.77117062
185Stomach cancer (HP:0012126)1.76893718
186Abnormal urine output (HP:0012590)1.71624854
187Pachygyria (HP:0001302)1.71386486
188Tubulointerstitial fibrosis (HP:0005576)1.70322788
189Abnormality of renin-angiotensin system (HP:0000847)1.67300115
190Partial agenesis of the corpus callosum (HP:0001338)1.66772326
191Postaxial foot polydactyly (HP:0001830)1.66291895
192Retinitis pigmentosa (HP:0000510)1.65942874
193Macular degeneration (HP:0000608)1.65325876
194Hypothermia (HP:0002045)1.63465410
195Abnormality of glycine metabolism (HP:0010895)1.61248472
196Abnormality of serine family amino acid metabolism (HP:0010894)1.61248472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.65294532
2NME25.06197398
3BMPR1B3.87766317
4ADRBK23.39855368
5MAP4K13.28851854
6BUB13.21667786
7INSRR3.17688105
8BLK2.88411671
9ZAK2.85884179
10WNK42.72995715
11PIM22.60113934
12TESK22.55287233
13IRAK32.54068101
14GRK12.51372582
15SCYL22.50063944
16STK162.24993768
17WEE12.23516657
18EIF2AK12.20679937
19ERN12.16664324
20LATS12.06575387
21TBK12.05178321
22KDR2.00976884
23IRAK41.98481876
24STK38L1.95605715
25ZAP701.93038372
26TAOK31.92181069
27BCKDK1.92050487
28PNCK1.86657970
29WNK31.85895228
30TYK21.85390531
31MAPK131.84482191
32TXK1.83103801
33KIT1.76949725
34ARAF1.74189003
35CASK1.74013245
36MAP4K21.72274918
37OXSR11.68824690
38NUAK11.68327602
39EIF2AK31.64433997
40MAP3K111.62851778
41TGFBR11.58831856
42DAPK21.58072394
43STK391.57447030
44TESK11.49554059
45RPS6KA41.48006314
46NTRK31.45604388
47ADRBK11.42477316
48LRRK21.38530061
49JAK31.38158606
50IKBKE1.35195845
51IKBKB1.34016420
52ACVR1B1.28365141
53MKNK21.27331119
54NEK21.25272147
55MAPK151.24804554
56MARK11.21869662
57EPHA21.19784858
58MAP3K41.17325669
59ABL21.16033505
60MAPKAPK31.13488490
61MAP2K21.12861488
62AKT31.05953664
63FLT31.04958681
64CSF1R1.04841394
65PRKCG1.00560601
66PLK40.99522359
67MAP3K130.97479125
68PIK3CA0.95049922
69BRSK20.94919902
70SYK0.94412664
71PIM10.94262915
72PAK30.94148137
73BRAF0.93976262
74NME10.92671438
75MOS0.92441270
76MAP3K140.90381668
77CAMK1D0.89684202
78MARK30.89391224
79VRK10.88577039
80PRKCE0.88134008
81PBK0.88079104
82STK30.88009440
83GRK60.87816486
84FGFR40.86841304
85STK100.86782990
86DYRK30.83091458
87MAP3K80.82343380
88BTK0.80049462
89MAP2K30.79672825
90LYN0.79513442
91TTK0.78959198
92IRAK20.78013141
93PLK10.77754007
94LCK0.77300697
95PIK3CG0.76740845
96CSNK1A1L0.76359104
97CAMK1G0.75818768
98TLK10.75391478
99KSR20.75211089
100PRKAA20.74996518
101MAP3K30.73803348
102PHKG10.73649169
103PHKG20.73649169
104IRAK10.72315533
105MAPKAPK50.72281977
106PAK10.71531837
107CDK70.68835789
108TRIB30.68740436
109PRKG20.68022813
110CSNK1G20.66953691
111MAP2K60.65619020
112TRPM70.65281424
113PAK40.63720852
114RIPK40.63321972
115TIE10.63057429
116AURKB0.62348712
117AURKA0.62159755
118MAP2K70.61736057
119CDK40.61521677
120TSSK60.61419739
121TEC0.61264604
122PTK2B0.60703126
123CAMKK20.60399816
124PASK0.59746897
125CHUK0.59397407
126MST40.58630212
127TNIK0.57844693
128NEK10.56557867
129MATK0.56307650
130WNK10.55657986
131CAMK2A0.55575295
132LIMK10.54283705
133STK380.53291167
134PKN10.51053980
135RPS6KB20.50327222
136STK40.49866215
137CDK190.49519180
138GRK70.48543508
139PRKCI0.48475679
140CSNK2A10.48223395
141ILK0.47740569
142CSNK1G10.47234117
143RPS6KA50.47211188
144OBSCN0.46851556
145TAF10.46510456
146STK110.46302082
147CSNK1G30.45584505
148BRSK10.45198104
149CSK0.44571331
150DYRK20.43675041
151JAK10.43300165
152CAMK10.43026824
153PINK10.42967875
154PRKAA10.42831847
155PRKACA0.42788981
156HCK0.42375203
157CSNK2A20.42308809
158PRKCQ0.42259551
159NLK0.42161331
160RPS6KA60.42112446
161NTRK20.41604496
162PRKCD0.41237569
163MKNK10.40953840
164RAF10.39198558
165CSNK1D0.38710956
166JAK20.38463385
167MAP2K10.37839849
168DAPK30.35731528
169MELK0.34870432
170CSNK1A10.34823780
171PLK20.34212168
172CHEK20.33957969
173ATR0.33834525
174PRKCZ0.33091987
175SGK20.32162991
176PRKACB0.30693309
177PRKCA0.30333986
178ITK0.29248456
179PRKCH0.28704961
180SIK20.27186980
181MUSK0.25419920
182ERBB20.24117762

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.51023344
2Ribosome_Homo sapiens_hsa030104.18873060
3DNA replication_Homo sapiens_hsa030302.72012545
4Folate biosynthesis_Homo sapiens_hsa007902.71283120
5Phototransduction_Homo sapiens_hsa047442.66365407
6RNA polymerase_Homo sapiens_hsa030202.64450833
7Nitrogen metabolism_Homo sapiens_hsa009102.59168473
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.58190324
9Linoleic acid metabolism_Homo sapiens_hsa005912.57581917
10Butanoate metabolism_Homo sapiens_hsa006502.56793144
11Tryptophan metabolism_Homo sapiens_hsa003802.45908487
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40218046
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33968310
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30292955
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26301432
16Nicotine addiction_Homo sapiens_hsa050332.23061753
17Sulfur relay system_Homo sapiens_hsa041222.10913736
18Mismatch repair_Homo sapiens_hsa034302.07990078
19Pyrimidine metabolism_Homo sapiens_hsa002402.03100693
20Protein export_Homo sapiens_hsa030602.02253172
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.93496411
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92392441
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91616335
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89500857
25Oxidative phosphorylation_Homo sapiens_hsa001901.86532291
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.82537383
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80354935
28Base excision repair_Homo sapiens_hsa034101.80161009
29Homologous recombination_Homo sapiens_hsa034401.74160373
30Primary immunodeficiency_Homo sapiens_hsa053401.72292767
31Antigen processing and presentation_Homo sapiens_hsa046121.68892575
32Spliceosome_Homo sapiens_hsa030401.67815893
33Lysosome_Homo sapiens_hsa041421.67503271
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65032623
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.60590149
36ABC transporters_Homo sapiens_hsa020101.60333262
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59202034
38Nucleotide excision repair_Homo sapiens_hsa034201.56670300
39Parkinsons disease_Homo sapiens_hsa050121.55837820
40Taste transduction_Homo sapiens_hsa047421.53828596
41RNA transport_Homo sapiens_hsa030131.53415964
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53104128
43Chemical carcinogenesis_Homo sapiens_hsa052041.53072141
44Pentose phosphate pathway_Homo sapiens_hsa000301.51376003
45Ether lipid metabolism_Homo sapiens_hsa005651.48160981
46Other glycan degradation_Homo sapiens_hsa005111.42113194
47Histidine metabolism_Homo sapiens_hsa003401.38818117
48Leishmaniasis_Homo sapiens_hsa051401.35927493
49Morphine addiction_Homo sapiens_hsa050321.34014328
50Propanoate metabolism_Homo sapiens_hsa006401.32007397
51Legionellosis_Homo sapiens_hsa051341.29953465
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28984531
53Retinol metabolism_Homo sapiens_hsa008301.20984598
54Vitamin B6 metabolism_Homo sapiens_hsa007501.18307797
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.17943940
56Peroxisome_Homo sapiens_hsa041461.17576397
57Regulation of autophagy_Homo sapiens_hsa041401.17372179
58Allograft rejection_Homo sapiens_hsa053301.14310187
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13995509
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13332361
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12425173
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11779701
63beta-Alanine metabolism_Homo sapiens_hsa004101.09078040
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.08031436
65Ovarian steroidogenesis_Homo sapiens_hsa049131.07243584
66Glutamatergic synapse_Homo sapiens_hsa047241.07228624
67GABAergic synapse_Homo sapiens_hsa047271.06527375
68NF-kappa B signaling pathway_Homo sapiens_hsa040641.06034292
69Graft-versus-host disease_Homo sapiens_hsa053321.04867453
70Serotonergic synapse_Homo sapiens_hsa047261.04467797
71Shigellosis_Homo sapiens_hsa051311.03634721
72Glycerolipid metabolism_Homo sapiens_hsa005611.03619256
73Arachidonic acid metabolism_Homo sapiens_hsa005901.03031419
74Galactose metabolism_Homo sapiens_hsa000521.02578694
75Circadian entrainment_Homo sapiens_hsa047130.99588712
76Huntingtons disease_Homo sapiens_hsa050160.99408865
77Measles_Homo sapiens_hsa051620.97721584
78Olfactory transduction_Homo sapiens_hsa047400.97324083
79p53 signaling pathway_Homo sapiens_hsa041150.97039361
80Insulin secretion_Homo sapiens_hsa049110.96819377
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93582072
82Herpes simplex infection_Homo sapiens_hsa051680.93516724
83One carbon pool by folate_Homo sapiens_hsa006700.92359756
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91931541
85Fructose and mannose metabolism_Homo sapiens_hsa000510.87812247
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86558634
87Epstein-Barr virus infection_Homo sapiens_hsa051690.85950940
88Alzheimers disease_Homo sapiens_hsa050100.85156215
89Calcium signaling pathway_Homo sapiens_hsa040200.84381844
90Asthma_Homo sapiens_hsa053100.81854654
91Rheumatoid arthritis_Homo sapiens_hsa053230.80988885
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80876959
93Cardiac muscle contraction_Homo sapiens_hsa042600.80351536
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.80220320
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79818225
96Purine metabolism_Homo sapiens_hsa002300.79699223
97Apoptosis_Homo sapiens_hsa042100.78740259
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78683002
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77950535
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76846915
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76498708
102Fatty acid degradation_Homo sapiens_hsa000710.75924800
103Tuberculosis_Homo sapiens_hsa051520.75660856
104Pertussis_Homo sapiens_hsa051330.73928946
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73427845
106Sphingolipid metabolism_Homo sapiens_hsa006000.73180511
107Biosynthesis of amino acids_Homo sapiens_hsa012300.73144925
108Hematopoietic cell lineage_Homo sapiens_hsa046400.72467849
109Cell cycle_Homo sapiens_hsa041100.71172797
110Dorso-ventral axis formation_Homo sapiens_hsa043200.71117429
111Caffeine metabolism_Homo sapiens_hsa002320.69902074
112Fat digestion and absorption_Homo sapiens_hsa049750.69623455
113N-Glycan biosynthesis_Homo sapiens_hsa005100.68734318
114Bile secretion_Homo sapiens_hsa049760.67645599
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67246235
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67222778
117Mineral absorption_Homo sapiens_hsa049780.67170459
118Vitamin digestion and absorption_Homo sapiens_hsa049770.66690048
119Carbon metabolism_Homo sapiens_hsa012000.66276087
120Fanconi anemia pathway_Homo sapiens_hsa034600.65501548
121Osteoclast differentiation_Homo sapiens_hsa043800.65446111
122RNA degradation_Homo sapiens_hsa030180.65236002
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.64759257
124Salivary secretion_Homo sapiens_hsa049700.64229603
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.64034334
126Sulfur metabolism_Homo sapiens_hsa009200.63982823
127Basal transcription factors_Homo sapiens_hsa030220.62690713
128Selenocompound metabolism_Homo sapiens_hsa004500.62494000
129Glutathione metabolism_Homo sapiens_hsa004800.60612135
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60139021
131Lysine degradation_Homo sapiens_hsa003100.59815176
132B cell receptor signaling pathway_Homo sapiens_hsa046620.58078979
133Influenza A_Homo sapiens_hsa051640.57381022
134Staphylococcus aureus infection_Homo sapiens_hsa051500.57288633
135Phagosome_Homo sapiens_hsa041450.57039226
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56753865
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54595567
138Malaria_Homo sapiens_hsa051440.53005072
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51255905
140Metabolic pathways_Homo sapiens_hsa011000.50569773
141Salmonella infection_Homo sapiens_hsa051320.50129417
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49774434
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.46980710
144Fatty acid biosynthesis_Homo sapiens_hsa000610.46628336
145Type I diabetes mellitus_Homo sapiens_hsa049400.46499905
146Collecting duct acid secretion_Homo sapiens_hsa049660.45135974
147Vibrio cholerae infection_Homo sapiens_hsa051100.43225181
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.43191858
149Dopaminergic synapse_Homo sapiens_hsa047280.43011726
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42630959
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42139364
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42110670
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41811782
154Acute myeloid leukemia_Homo sapiens_hsa052210.41563131
155Tyrosine metabolism_Homo sapiens_hsa003500.41026191
156Cholinergic synapse_Homo sapiens_hsa047250.39610776
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38317427
158Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36571822
159Long-term depression_Homo sapiens_hsa047300.36055767
160Gastric acid secretion_Homo sapiens_hsa049710.35816236
161Cocaine addiction_Homo sapiens_hsa050300.34624755
162T cell receptor signaling pathway_Homo sapiens_hsa046600.33842090
163Circadian rhythm_Homo sapiens_hsa047100.29913862
164Glycerophospholipid metabolism_Homo sapiens_hsa005640.29866206
165cAMP signaling pathway_Homo sapiens_hsa040240.28303784

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