

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle exocytosis (GO:0016079) | 6.04452814 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.59946526 |
| 3 | neuron cell-cell adhesion (GO:0007158) | 5.53143280 |
| 4 | glutamate secretion (GO:0014047) | 5.48066136 |
| 5 | vocalization behavior (GO:0071625) | 5.41768146 |
| 6 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.15559195 |
| 7 | pyrimidine nucleobase catabolic process (GO:0006208) | 5.06184778 |
| 8 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.04278928 |
| 9 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.92014267 |
| 10 | locomotory exploration behavior (GO:0035641) | 4.82624749 |
| 11 | synaptic vesicle maturation (GO:0016188) | 4.79154562 |
| 12 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.77988356 |
| 13 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 4.65901715 |
| 14 | neuronal action potential propagation (GO:0019227) | 4.61697838 |
| 15 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.57697598 |
| 16 | nucleobase catabolic process (GO:0046113) | 4.53378858 |
| 17 | protein localization to synapse (GO:0035418) | 4.51260536 |
| 18 | regulation of synaptic vesicle transport (GO:1902803) | 4.43950002 |
| 19 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.37836954 |
| 20 | neurotransmitter secretion (GO:0007269) | 4.30771210 |
| 21 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.21242714 |
| 22 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.17951758 |
| 23 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.16502596 |
| 24 | neuron-neuron synaptic transmission (GO:0007270) | 4.11258205 |
| 25 | neuron recognition (GO:0008038) | 4.08693274 |
| 26 | behavioral response to nicotine (GO:0035095) | 4.07724269 |
| 27 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.06913915 |
| 28 | dendritic spine morphogenesis (GO:0060997) | 4.01987798 |
| 29 | synaptic transmission, glutamatergic (GO:0035249) | 4.00186950 |
| 30 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.96994550 |
| 31 | neurofilament cytoskeleton organization (GO:0060052) | 3.93389830 |
| 32 | layer formation in cerebral cortex (GO:0021819) | 3.86824831 |
| 33 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.86275368 |
| 34 | glutamate receptor signaling pathway (GO:0007215) | 3.83628025 |
| 35 | axonal fasciculation (GO:0007413) | 3.83151478 |
| 36 | exploration behavior (GO:0035640) | 3.80557162 |
| 37 | presynaptic membrane assembly (GO:0097105) | 3.78582465 |
| 38 | establishment of mitochondrion localization (GO:0051654) | 3.75019931 |
| 39 | neurotransmitter transport (GO:0006836) | 3.70922687 |
| 40 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.68628372 |
| 41 | startle response (GO:0001964) | 3.67060501 |
| 42 | regulation of postsynaptic membrane potential (GO:0060078) | 3.64884836 |
| 43 | behavioral response to cocaine (GO:0048148) | 3.63285555 |
| 44 | gamma-aminobutyric acid transport (GO:0015812) | 3.59139744 |
| 45 | proline transport (GO:0015824) | 3.59110707 |
| 46 | membrane hyperpolarization (GO:0060081) | 3.55890716 |
| 47 | presynaptic membrane organization (GO:0097090) | 3.55220944 |
| 48 | transmission of nerve impulse (GO:0019226) | 3.51637320 |
| 49 | response to histamine (GO:0034776) | 3.51506207 |
| 50 | positive regulation of membrane potential (GO:0045838) | 3.50244995 |
| 51 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.48801531 |
| 52 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.47473270 |
| 53 | positive regulation of gastrulation (GO:2000543) | 3.46804684 |
| 54 | retinal ganglion cell axon guidance (GO:0031290) | 3.45427589 |
| 55 | regulation of neurotransmitter levels (GO:0001505) | 3.44170869 |
| 56 | cell migration in hindbrain (GO:0021535) | 3.43147839 |
| 57 | long-term synaptic potentiation (GO:0060291) | 3.41309108 |
| 58 | regulation of synapse structural plasticity (GO:0051823) | 3.38485647 |
| 59 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.36194193 |
| 60 | positive regulation of synapse assembly (GO:0051965) | 3.35528560 |
| 61 | long-term memory (GO:0007616) | 3.35256887 |
| 62 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.35011425 |
| 63 | mitochondrion transport along microtubule (GO:0047497) | 3.35011425 |
| 64 | postsynaptic membrane organization (GO:0001941) | 3.33375177 |
| 65 | regulation of neurotransmitter secretion (GO:0046928) | 3.33113813 |
| 66 | regulation of synaptic plasticity (GO:0048167) | 3.29825082 |
| 67 | synaptic vesicle endocytosis (GO:0048488) | 3.29788473 |
| 68 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.24026974 |
| 69 | cellular ketone body metabolic process (GO:0046950) | 3.23055433 |
| 70 | glycerophospholipid catabolic process (GO:0046475) | 3.22223355 |
| 71 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.20010822 |
| 72 | neuronal action potential (GO:0019228) | 3.17332577 |
| 73 | neurotransmitter uptake (GO:0001504) | 3.15245172 |
| 74 | cerebellar granule cell differentiation (GO:0021707) | 3.12394406 |
| 75 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.12142603 |
| 76 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.11710040 |
| 77 | positive regulation of neurological system process (GO:0031646) | 3.11169733 |
| 78 | regulation of glutamate secretion (GO:0014048) | 3.10703113 |
| 79 | striatum development (GO:0021756) | 3.09724673 |
| 80 | membrane depolarization (GO:0051899) | 3.09575690 |
| 81 | establishment of synaptic vesicle localization (GO:0097480) | 3.08477340 |
| 82 | synaptic vesicle transport (GO:0048489) | 3.08477340 |
| 83 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.07969902 |
| 84 | insulin secretion (GO:0030073) | 3.07844022 |
| 85 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.07078306 |
| 86 | regulation of synaptic transmission, GABAergic (GO:0032228) | 3.06703047 |
| 87 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.06108894 |
| 88 | mechanosensory behavior (GO:0007638) | 3.05917197 |
| 89 | serotonin receptor signaling pathway (GO:0007210) | 3.05758174 |
| 90 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.05616341 |
| 91 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.05616341 |
| 92 | neuromuscular process controlling posture (GO:0050884) | 3.05399595 |
| 93 | glycosphingolipid biosynthetic process (GO:0006688) | 3.04453257 |
| 94 | synapse assembly (GO:0007416) | 3.03818718 |
| 95 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.03376554 |
| 96 | activation of protein kinase A activity (GO:0034199) | 3.01126173 |
| 97 | innervation (GO:0060384) | 3.01006752 |
| 98 | regulation of neurotransmitter transport (GO:0051588) | 2.99973265 |
| 99 | synaptic transmission (GO:0007268) | 2.99024669 |
| 100 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.98873681 |
| 101 | dendrite morphogenesis (GO:0048813) | 2.98169573 |
| 102 | adult walking behavior (GO:0007628) | 2.97578292 |
| 103 | regulation of synapse assembly (GO:0051963) | 2.97146753 |
| 104 | protein localization to cilium (GO:0061512) | 2.96962008 |
| 105 | response to cocaine (GO:0042220) | 2.95827581 |
| 106 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.93994352 |
| 107 | urinary tract smooth muscle contraction (GO:0014848) | 2.93466918 |
| 108 | regulation of respiratory system process (GO:0044065) | 2.93323017 |
| 109 | learning (GO:0007612) | 2.92623711 |
| 110 | adult feeding behavior (GO:0008343) | 2.90063551 |
| 111 | nonmotile primary cilium assembly (GO:0035058) | 2.87546414 |
| 112 | neuronal ion channel clustering (GO:0045161) | 2.86772378 |
| 113 | positive regulation of neurotransmitter transport (GO:0051590) | 2.86731092 |
| 114 | intraspecies interaction between organisms (GO:0051703) | 2.86690218 |
| 115 | social behavior (GO:0035176) | 2.86690218 |
| 116 | regulation of synaptic transmission (GO:0050804) | 2.86598479 |
| 117 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.86138646 |
| 118 | regulation of transmission of nerve impulse (GO:0051969) | 2.86125414 |
| 119 | detection of calcium ion (GO:0005513) | 2.85584556 |
| 120 | membrane depolarization during action potential (GO:0086010) | 2.85322692 |
| 121 | negative regulation of neurotransmitter transport (GO:0051589) | 2.85157983 |
| 122 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.84916213 |
| 123 | auditory behavior (GO:0031223) | 2.84454193 |
| 124 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.84184366 |
| 125 | ketone body metabolic process (GO:1902224) | 2.84156353 |
| 126 | epithelial cell fate commitment (GO:0072148) | 2.83584367 |
| 127 | synapse organization (GO:0050808) | 2.83374807 |
| 128 | negative regulation of axon extension (GO:0030517) | 2.82221043 |
| 129 | neuron fate determination (GO:0048664) | 2.80506717 |
| 130 | cerebellum development (GO:0021549) | 2.80370135 |
| 131 | negative regulation of dendrite development (GO:2000171) | 2.78445123 |
| 132 | endocrine pancreas development (GO:0031018) | 2.74471496 |
| 133 | spinal cord motor neuron differentiation (GO:0021522) | 2.71316298 |
| 134 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 2.70474657 |
| 135 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.66664075 |
| 136 | central nervous system neuron axonogenesis (GO:0021955) | 2.65371263 |
| 137 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.63614414 |
| 138 | atrial cardiac muscle cell action potential (GO:0086014) | 2.63476733 |
| 139 | axon extension (GO:0048675) | 2.62212997 |
| 140 | synaptic transmission, cholinergic (GO:0007271) | 2.62154551 |
| 141 | N-glycan processing (GO:0006491) | 2.58790270 |
| 142 | action potential (GO:0001508) | 2.55724635 |
| 143 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.55527861 |
| 144 | negative regulation of appetite (GO:0032099) | 2.53669763 |
| 145 | negative regulation of response to food (GO:0032096) | 2.53669763 |
| 146 | response to auditory stimulus (GO:0010996) | 2.52164731 |
| 147 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.52014999 |
| 148 | regulation of feeding behavior (GO:0060259) | 2.49976052 |
| 149 | adult behavior (GO:0030534) | 2.49736346 |
| 150 | response to dietary excess (GO:0002021) | 2.49146820 |
| 151 | cell differentiation in spinal cord (GO:0021515) | 2.48193168 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.56812658 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.96114730 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.14975769 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.02387436 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.01142627 |
| 6 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.91481403 |
| 7 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.74628957 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.60087563 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.60087563 |
| 10 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.56892351 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.54942680 |
| 12 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.54232287 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.51691803 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.48120388 |
| 15 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.46514609 |
| 16 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.45343590 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.39388291 |
| 18 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.37119197 |
| 19 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.36276199 |
| 20 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.36091526 |
| 21 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.34116145 |
| 22 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.20154509 |
| 23 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.14290180 |
| 24 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.12746906 |
| 25 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.12664596 |
| 26 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.11605316 |
| 27 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.10251562 |
| 28 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.08724270 |
| 29 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.04481797 |
| 30 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.98839219 |
| 31 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.98486146 |
| 32 | VDR_22108803_ChIP-Seq_LS180_Human | 1.94455777 |
| 33 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.85196370 |
| 34 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.83515609 |
| 35 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.79301227 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.79063332 |
| 37 | P300_19829295_ChIP-Seq_ESCs_Human | 1.75186761 |
| 38 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.72417853 |
| 39 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.61027643 |
| 40 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.58367886 |
| 41 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.54394139 |
| 42 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.53989857 |
| 43 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.53352678 |
| 44 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.51934672 |
| 45 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.50472252 |
| 46 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.47937543 |
| 47 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.45394269 |
| 48 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.44580486 |
| 49 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.44155220 |
| 50 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.43481840 |
| 51 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.41774999 |
| 52 | FUS_26573619_Chip-Seq_HEK293_Human | 1.41380442 |
| 53 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.40142123 |
| 54 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.40023063 |
| 55 | AR_25329375_ChIP-Seq_VCAP_Human | 1.38931595 |
| 56 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.38858917 |
| 57 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.38715140 |
| 58 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.36255595 |
| 59 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.32570363 |
| 60 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.31876167 |
| 61 | EWS_26573619_Chip-Seq_HEK293_Human | 1.30940689 |
| 62 | STAT3_23295773_ChIP-Seq_U87_Human | 1.26922666 |
| 63 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.26008354 |
| 64 | * IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.25662195 |
| 65 | * CBP_20019798_ChIP-Seq_JUKART_Human | 1.25662195 |
| 66 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.23637830 |
| 67 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.22176442 |
| 68 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.21472875 |
| 69 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.20482237 |
| 70 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.19231691 |
| 71 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.16102649 |
| 72 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.16015235 |
| 73 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.15020724 |
| 74 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.14253481 |
| 75 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.12545468 |
| 76 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.12260058 |
| 77 | AR_19668381_ChIP-Seq_PC3_Human | 1.11110776 |
| 78 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.10152194 |
| 79 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.10134429 |
| 80 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.08766278 |
| 81 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.08432946 |
| 82 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.07755160 |
| 83 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.07674887 |
| 84 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.07274692 |
| 85 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.05677109 |
| 86 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.05404496 |
| 87 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.04863448 |
| 88 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.04726300 |
| 89 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.04091209 |
| 90 | JUN_21703547_ChIP-Seq_K562_Human | 1.04039216 |
| 91 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.01573465 |
| 92 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.01487338 |
| 93 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.01188891 |
| 94 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.00672301 |
| 95 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00462072 |
| 96 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.00445422 |
| 97 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.00272349 |
| 98 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99061758 |
| 99 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.98878813 |
| 100 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.98742839 |
| 101 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.98253036 |
| 102 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.98116818 |
| 103 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.97940504 |
| 104 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.97936534 |
| 105 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.97649290 |
| 106 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.96178885 |
| 107 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.96131721 |
| 108 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.95953704 |
| 109 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.95402688 |
| 110 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.94725449 |
| 111 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.94122113 |
| 112 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.93161351 |
| 113 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93156809 |
| 114 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.92744222 |
| 115 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.92744222 |
| 116 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.91320535 |
| 117 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.88693516 |
| 118 | * KDM2B_26808549_Chip-Seq_REH_Human | 0.87974398 |
| 119 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.87688261 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 5.60400901 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 5.38163939 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.87419605 |
| 4 | MP0004270_analgesia | 3.55510269 |
| 5 | MP0009046_muscle_twitch | 3.34563752 |
| 6 | MP0002064_seizures | 3.34466680 |
| 7 | MP0009745_abnormal_behavioral_response | 3.26552564 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.00338205 |
| 9 | MP0001968_abnormal_touch/_nociception | 2.75465905 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.71472737 |
| 11 | MP0002735_abnormal_chemical_nociception | 2.66867862 |
| 12 | MP0002272_abnormal_nervous_system | 2.66559290 |
| 13 | MP0001486_abnormal_startle_reflex | 2.60868614 |
| 14 | MP0005423_abnormal_somatic_nervous | 2.57924607 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.49921969 |
| 16 | MP0001529_abnormal_vocalization | 2.31444001 |
| 17 | MP0006276_abnormal_autonomic_nervous | 2.25622587 |
| 18 | MP0001501_abnormal_sleep_pattern | 2.25150864 |
| 19 | MP0002736_abnormal_nociception_after | 2.16712580 |
| 20 | MP0000569_abnormal_digit_pigmentation | 2.13421298 |
| 21 | MP0001440_abnormal_grooming_behavior | 2.11459533 |
| 22 | MP0008877_abnormal_DNA_methylation | 2.09715252 |
| 23 | MP0002067_abnormal_sensory_capabilities | 2.07939751 |
| 24 | MP0002822_catalepsy | 2.06487912 |
| 25 | MP0001984_abnormal_olfaction | 2.04999725 |
| 26 | MP0001970_abnormal_pain_threshold | 1.97354719 |
| 27 | MP0003122_maternal_imprinting | 1.96754647 |
| 28 | MP0000778_abnormal_nervous_system | 1.96408033 |
| 29 | MP0005386_behavior/neurological_phenoty | 1.90409596 |
| 30 | MP0004924_abnormal_behavior | 1.90409596 |
| 31 | MP0002837_dystrophic_cardiac_calcinosis | 1.85680858 |
| 32 | MP0002638_abnormal_pupillary_reflex | 1.85296050 |
| 33 | MP0002733_abnormal_thermal_nociception | 1.83719196 |
| 34 | MP0002184_abnormal_innervation | 1.82936386 |
| 35 | MP0010386_abnormal_urinary_bladder | 1.81796859 |
| 36 | MP0004811_abnormal_neuron_physiology | 1.69799725 |
| 37 | MP0008569_lethality_at_weaning | 1.69388112 |
| 38 | MP0001905_abnormal_dopamine_level | 1.66301885 |
| 39 | MP0004142_abnormal_muscle_tone | 1.64201742 |
| 40 | MP0002557_abnormal_social/conspecific_i | 1.62808890 |
| 41 | MP0004133_heterotaxia | 1.61648427 |
| 42 | MP0000537_abnormal_urethra_morphology | 1.61126394 |
| 43 | MP0005646_abnormal_pituitary_gland | 1.58924176 |
| 44 | MP0003283_abnormal_digestive_organ | 1.57486375 |
| 45 | MP0002066_abnormal_motor_capabilities/c | 1.46499740 |
| 46 | MP0003787_abnormal_imprinting | 1.45123027 |
| 47 | MP0002882_abnormal_neuron_morphology | 1.44188310 |
| 48 | MP0003890_abnormal_embryonic-extraembry | 1.44147013 |
| 49 | MP0002928_abnormal_bile_duct | 1.43757355 |
| 50 | MP0000955_abnormal_spinal_cord | 1.43424459 |
| 51 | MP0002909_abnormal_adrenal_gland | 1.43174878 |
| 52 | MP0003329_amyloid_beta_deposits | 1.42208477 |
| 53 | MP0003879_abnormal_hair_cell | 1.38863742 |
| 54 | MP0002163_abnormal_gland_morphology | 1.34694784 |
| 55 | MP0008872_abnormal_physiological_respon | 1.33746975 |
| 56 | MP0001502_abnormal_circadian_rhythm | 1.32768436 |
| 57 | MP0002102_abnormal_ear_morphology | 1.32754414 |
| 58 | MP0003123_paternal_imprinting | 1.31356740 |
| 59 | MP0004742_abnormal_vestibular_system | 1.29595734 |
| 60 | MP0003195_calcinosis | 1.25855507 |
| 61 | MP0000751_myopathy | 1.25461994 |
| 62 | MP0005379_endocrine/exocrine_gland_phen | 1.23563623 |
| 63 | MP0001944_abnormal_pancreas_morphology | 1.18697414 |
| 64 | MP0005645_abnormal_hypothalamus_physiol | 1.18280393 |
| 65 | MP0009780_abnormal_chondrocyte_physiolo | 1.18250897 |
| 66 | MP0005551_abnormal_eye_electrophysiolog | 1.17736746 |
| 67 | MP0005394_taste/olfaction_phenotype | 1.16829339 |
| 68 | MP0005499_abnormal_olfactory_system | 1.16829339 |
| 69 | MP0003633_abnormal_nervous_system | 1.15176155 |
| 70 | MP0000013_abnormal_adipose_tissue | 1.13235349 |
| 71 | MP0002229_neurodegeneration | 1.13009895 |
| 72 | MP0001188_hyperpigmentation | 1.11475801 |
| 73 | MP0005187_abnormal_penis_morphology | 1.07510221 |
| 74 | MP0002152_abnormal_brain_morphology | 1.06373656 |
| 75 | MP0006072_abnormal_retinal_apoptosis | 1.05486198 |
| 76 | MP0002693_abnormal_pancreas_physiology | 1.05367960 |
| 77 | MP0002876_abnormal_thyroid_physiology | 1.03345968 |
| 78 | MP0004885_abnormal_endolymph | 1.03129398 |
| 79 | MP0003631_nervous_system_phenotype | 1.02291411 |
| 80 | MP0001963_abnormal_hearing_physiology | 0.98890284 |
| 81 | MP0002069_abnormal_eating/drinking_beha | 0.97285347 |
| 82 | MP0001986_abnormal_taste_sensitivity | 0.95815541 |
| 83 | MP0004858_abnormal_nervous_system | 0.94726941 |
| 84 | MP0000920_abnormal_myelination | 0.93257612 |
| 85 | MP0004085_abnormal_heartbeat | 0.91817007 |
| 86 | MP0004145_abnormal_muscle_electrophysio | 0.90868977 |
| 87 | MP0000631_abnormal_neuroendocrine_gland | 0.88463147 |
| 88 | MP0003634_abnormal_glial_cell | 0.88198465 |
| 89 | MP0002752_abnormal_somatic_nervous | 0.86894333 |
| 90 | MP0001177_atelectasis | 0.86184056 |
| 91 | MP0004215_abnormal_myocardial_fiber | 0.85417248 |
| 92 | MP0000566_synostosis | 0.84955309 |
| 93 | MP0004043_abnormal_pH_regulation | 0.84757912 |
| 94 | MP0002751_abnormal_autonomic_nervous | 0.84188479 |
| 95 | MP0008874_decreased_physiological_sensi | 0.83474842 |
| 96 | MP0002938_white_spotting | 0.81786733 |
| 97 | MP0002078_abnormal_glucose_homeostasis | 0.81050041 |
| 98 | MP0000427_abnormal_hair_cycle | 0.80846136 |
| 99 | MP0002653_abnormal_ependyma_morphology | 0.79875967 |
| 100 | MP0002090_abnormal_vision | 0.78134697 |
| 101 | MP0005448_abnormal_energy_balance | 0.77147176 |
| 102 | MP0003632_abnormal_nervous_system | 0.75938969 |
| 103 | MP0005195_abnormal_posterior_eye | 0.74774892 |
| 104 | MP0003121_genomic_imprinting | 0.74042841 |
| 105 | MP0003690_abnormal_glial_cell | 0.73688959 |
| 106 | MP0001943_abnormal_respiration | 0.73533406 |
| 107 | MP0001664_abnormal_digestion | 0.72768492 |
| 108 | MP0008995_early_reproductive_senescence | 0.72243690 |
| 109 | MP0003953_abnormal_hormone_level | 0.70173391 |
| 110 | MP0005535_abnormal_body_temperature | 0.69925676 |
| 111 | MP0005253_abnormal_eye_physiology | 0.67901621 |
| 112 | MP0008789_abnormal_olfactory_epithelium | 0.67015800 |
| 113 | MP0001919_abnormal_reproductive_system | 0.65797527 |
| 114 | MP0004233_abnormal_muscle_weight | 0.65617427 |
| 115 | MP0002160_abnormal_reproductive_system | 0.65108582 |
| 116 | MP0000538_abnormal_urinary_bladder | 0.63717979 |
| 117 | MP0000026_abnormal_inner_ear | 0.63515350 |
| 118 | MP0001299_abnormal_eye_distance/ | 0.63249903 |
| 119 | MP0001485_abnormal_pinna_reflex | 0.63026446 |
| 120 | MP0005409_darkened_coat_color | 0.62670148 |
| 121 | MP0003137_abnormal_impulse_conducting | 0.58946451 |
| 122 | MP0000534_abnormal_ureter_morphology | 0.58063274 |
| 123 | MP0010770_preweaning_lethality | 0.57192147 |
| 124 | MP0002082_postnatal_lethality | 0.57192147 |
| 125 | MP0010769_abnormal_survival | 0.55180610 |
| 126 | MP0010768_mortality/aging | 0.52160779 |
| 127 | MP0003646_muscle_fatigue | 0.52068152 |
| 128 | MP0003861_abnormal_nervous_system | 0.51900548 |
| 129 | MP0008004_abnormal_stomach_pH | 0.51744523 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.68333490 |
| 2 | Focal seizures (HP:0007359) | 5.61591378 |
| 3 | Myokymia (HP:0002411) | 5.44535651 |
| 4 | Atonic seizures (HP:0010819) | 5.36626392 |
| 5 | Epileptic encephalopathy (HP:0200134) | 5.08237226 |
| 6 | Visual hallucinations (HP:0002367) | 4.96865423 |
| 7 | Febrile seizures (HP:0002373) | 4.79126263 |
| 8 | Hyperventilation (HP:0002883) | 4.53639690 |
| 9 | Absence seizures (HP:0002121) | 4.52801157 |
| 10 | Limb dystonia (HP:0002451) | 4.26536796 |
| 11 | Dialeptic seizures (HP:0011146) | 4.10139170 |
| 12 | Progressive cerebellar ataxia (HP:0002073) | 4.01890934 |
| 13 | Generalized tonic-clonic seizures (HP:0002069) | 3.91756159 |
| 14 | Abnormal pancreas size (HP:0012094) | 3.63558435 |
| 15 | Broad-based gait (HP:0002136) | 3.61026823 |
| 16 | Pheochromocytoma (HP:0002666) | 3.20468045 |
| 17 | Abnormal eating behavior (HP:0100738) | 3.16428607 |
| 18 | Hypomagnesemia (HP:0002917) | 3.03561796 |
| 19 | Progressive inability to walk (HP:0002505) | 2.96588104 |
| 20 | Amblyopia (HP:0000646) | 2.94551534 |
| 21 | Supranuclear gaze palsy (HP:0000605) | 2.93033277 |
| 22 | Truncal ataxia (HP:0002078) | 2.87728792 |
| 23 | Neuroendocrine neoplasm (HP:0100634) | 2.86064534 |
| 24 | Poor eye contact (HP:0000817) | 2.84119937 |
| 25 | Gaze-evoked nystagmus (HP:0000640) | 2.80329985 |
| 26 | Failure to thrive in infancy (HP:0001531) | 2.72970033 |
| 27 | Polyphagia (HP:0002591) | 2.72604095 |
| 28 | Lissencephaly (HP:0001339) | 2.72408977 |
| 29 | Gait imbalance (HP:0002141) | 2.71020150 |
| 30 | Impaired social interactions (HP:0000735) | 2.70799293 |
| 31 | Abnormal social behavior (HP:0012433) | 2.70799293 |
| 32 | Hypoglycemic coma (HP:0001325) | 2.70685392 |
| 33 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.69929366 |
| 34 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.67049475 |
| 35 | Pachygyria (HP:0001302) | 2.64476024 |
| 36 | Pancreatic fibrosis (HP:0100732) | 2.62390810 |
| 37 | Drooling (HP:0002307) | 2.61835140 |
| 38 | Excessive salivation (HP:0003781) | 2.61835140 |
| 39 | Ankle clonus (HP:0011448) | 2.61734727 |
| 40 | Anxiety (HP:0000739) | 2.60755649 |
| 41 | Depression (HP:0000716) | 2.58930043 |
| 42 | Postural instability (HP:0002172) | 2.57864764 |
| 43 | Action tremor (HP:0002345) | 2.57030886 |
| 44 | Hypoglycemic seizures (HP:0002173) | 2.53081903 |
| 45 | Ketoacidosis (HP:0001993) | 2.48778813 |
| 46 | Absent speech (HP:0001344) | 2.48369308 |
| 47 | Molar tooth sign on MRI (HP:0002419) | 2.48259464 |
| 48 | Abnormality of midbrain morphology (HP:0002418) | 2.48259464 |
| 49 | Dysdiadochokinesis (HP:0002075) | 2.45604047 |
| 50 | Abnormal hair whorl (HP:0010721) | 2.45493951 |
| 51 | Inability to walk (HP:0002540) | 2.44381633 |
| 52 | Dysmetria (HP:0001310) | 2.41570856 |
| 53 | Large for gestational age (HP:0001520) | 2.40723653 |
| 54 | Epileptiform EEG discharges (HP:0011182) | 2.40458139 |
| 55 | Acute necrotizing encephalopathy (HP:0006965) | 2.40282816 |
| 56 | Hypothermia (HP:0002045) | 2.38568098 |
| 57 | Hypoventilation (HP:0002791) | 2.38080841 |
| 58 | Pancreatic cysts (HP:0001737) | 2.37628460 |
| 59 | Congenital primary aphakia (HP:0007707) | 2.36315975 |
| 60 | Poor coordination (HP:0002370) | 2.35802862 |
| 61 | Nephronophthisis (HP:0000090) | 2.35435038 |
| 62 | Fetal akinesia sequence (HP:0001989) | 2.35366797 |
| 63 | Torticollis (HP:0000473) | 2.33227126 |
| 64 | True hermaphroditism (HP:0010459) | 2.31832013 |
| 65 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.31517150 |
| 66 | Abnormality of binocular vision (HP:0011514) | 2.31379808 |
| 67 | Diplopia (HP:0000651) | 2.31379808 |
| 68 | Generalized myoclonic seizures (HP:0002123) | 2.30270329 |
| 69 | Scanning speech (HP:0002168) | 2.29103530 |
| 70 | Poor speech (HP:0002465) | 2.29086395 |
| 71 | Abnormality of magnesium homeostasis (HP:0004921) | 2.28883119 |
| 72 | Esotropia (HP:0000565) | 2.28468041 |
| 73 | Spastic gait (HP:0002064) | 2.27404404 |
| 74 | Thickened helices (HP:0000391) | 2.27270128 |
| 75 | Bradykinesia (HP:0002067) | 2.27221505 |
| 76 | Focal dystonia (HP:0004373) | 2.26992617 |
| 77 | Abnormality of the corticospinal tract (HP:0002492) | 2.26632272 |
| 78 | Progressive macrocephaly (HP:0004481) | 2.26422292 |
| 79 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.25884014 |
| 80 | Akinesia (HP:0002304) | 2.25307801 |
| 81 | Urinary urgency (HP:0000012) | 2.24692579 |
| 82 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.24688479 |
| 83 | Double outlet right ventricle (HP:0001719) | 2.24073246 |
| 84 | Congenital malformation of the right heart (HP:0011723) | 2.24073246 |
| 85 | Termporal pattern (HP:0011008) | 2.23227395 |
| 86 | Insidious onset (HP:0003587) | 2.23227395 |
| 87 | EEG with generalized epileptiform discharges (HP:0011198) | 2.22595597 |
| 88 | Congenital stationary night blindness (HP:0007642) | 2.22545742 |
| 89 | Specific learning disability (HP:0001328) | 2.21154258 |
| 90 | Narrow forehead (HP:0000341) | 2.12238029 |
| 91 | Polyuria (HP:0000103) | 2.11394243 |
| 92 | Hypoplasia of the brainstem (HP:0002365) | 2.11286617 |
| 93 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.11286617 |
| 94 | Hypsarrhythmia (HP:0002521) | 2.10411666 |
| 95 | Mutism (HP:0002300) | 2.10378697 |
| 96 | Muscular hypotonia of the trunk (HP:0008936) | 2.09467126 |
| 97 | Medial flaring of the eyebrow (HP:0010747) | 2.09318508 |
| 98 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.09316331 |
| 99 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.09316331 |
| 100 | Nephrogenic diabetes insipidus (HP:0009806) | 2.08403690 |
| 101 | Status epilepticus (HP:0002133) | 2.07738959 |
| 102 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.07402966 |
| 103 | Gait ataxia (HP:0002066) | 2.05226521 |
| 104 | Type II lissencephaly (HP:0007260) | 2.04924807 |
| 105 | Shawl scrotum (HP:0000049) | 2.03944289 |
| 106 | Mitochondrial inheritance (HP:0001427) | 2.03266240 |
| 107 | Hemiplegia (HP:0002301) | 2.02494288 |
| 108 | Agitation (HP:0000713) | 2.02399001 |
| 109 | Abnormality of the labia minora (HP:0012880) | 2.00767141 |
| 110 | Cerebral inclusion bodies (HP:0100314) | 1.99860313 |
| 111 | Protruding tongue (HP:0010808) | 1.99370809 |
| 112 | Vaginal atresia (HP:0000148) | 1.99291622 |
| 113 | Spastic tetraplegia (HP:0002510) | 1.96594822 |
| 114 | Blue irides (HP:0000635) | 1.96055208 |
| 115 | Stereotypic behavior (HP:0000733) | 1.95715892 |
| 116 | Genital tract atresia (HP:0001827) | 1.95579605 |
| 117 | Chronic hepatic failure (HP:0100626) | 1.95215481 |
| 118 | Sensory axonal neuropathy (HP:0003390) | 1.95201890 |
| 119 | Polydipsia (HP:0001959) | 1.94915045 |
| 120 | Abnormal drinking behavior (HP:0030082) | 1.94915045 |
| 121 | Hemiparesis (HP:0001269) | 1.94629640 |
| 122 | Craniofacial dystonia (HP:0012179) | 1.94418417 |
| 123 | Growth hormone deficiency (HP:0000824) | 1.94022309 |
| 124 | Acute encephalopathy (HP:0006846) | 1.93503412 |
| 125 | Psychosis (HP:0000709) | 1.93446612 |
| 126 | Occipital encephalocele (HP:0002085) | 1.93406551 |
| 127 | Abnormality of the renal medulla (HP:0100957) | 1.91298915 |
| 128 | Type 2 muscle fiber atrophy (HP:0003554) | 1.90886049 |
| 129 | Abnormal urine output (HP:0012590) | 1.88784821 |
| 130 | Intestinal atresia (HP:0011100) | 1.86978478 |
| 131 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.86694738 |
| 132 | Prolonged QT interval (HP:0001657) | 1.84847992 |
| 133 | Hypogonadotrophic hypogonadism (HP:0000044) | 1.84258842 |
| 134 | Abnormality of alanine metabolism (HP:0010916) | 1.83939230 |
| 135 | Hyperalaninemia (HP:0003348) | 1.83939230 |
| 136 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.83939230 |
| 137 | Resting tremor (HP:0002322) | 1.83681190 |
| 138 | Labial hypoplasia (HP:0000066) | 1.83485132 |
| 139 | Abnormality of the renal cortex (HP:0011035) | 1.83127835 |
| 140 | X-linked dominant inheritance (HP:0001423) | 1.82544455 |
| 141 | Oligomenorrhea (HP:0000876) | 1.82323786 |
| 142 | Rigidity (HP:0002063) | 1.82176525 |
| 143 | Poor suck (HP:0002033) | 1.81819345 |
| 144 | Sleep apnea (HP:0010535) | 1.81690064 |
| 145 | Volvulus (HP:0002580) | 1.81298454 |
| 146 | Impaired smooth pursuit (HP:0007772) | 1.80873310 |
| 147 | Optic nerve hypoplasia (HP:0000609) | 1.79233446 |
| 148 | Hepatoblastoma (HP:0002884) | 1.76834193 |
| 149 | Hip dysplasia (HP:0001385) | 1.75791070 |
| 150 | Renal cortical cysts (HP:0000803) | 1.73056708 |
| 151 | Abnormality of renal excretion (HP:0011036) | 1.72697715 |
| 152 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.72643297 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K4 | 4.22310432 |
| 2 | MAP2K7 | 4.15150346 |
| 3 | FRK | 3.60243820 |
| 4 | PNCK | 3.37067722 |
| 5 | NTRK3 | 3.35488744 |
| 6 | MAP3K12 | 3.00631570 |
| 7 | MARK1 | 2.87034497 |
| 8 | CDK19 | 2.74228263 |
| 9 | MAP2K4 | 2.66135851 |
| 10 | CASK | 2.59997228 |
| 11 | EPHA4 | 2.58071548 |
| 12 | MAP4K2 | 2.57709132 |
| 13 | MAP3K9 | 2.39737240 |
| 14 | MINK1 | 2.33886829 |
| 15 | PAK6 | 2.16501810 |
| 16 | NTRK2 | 2.09350416 |
| 17 | DAPK2 | 2.00704390 |
| 18 | PLK2 | 1.96484770 |
| 19 | OXSR1 | 1.78052882 |
| 20 | DYRK2 | 1.68767871 |
| 21 | MAPK13 | 1.62470264 |
| 22 | PINK1 | 1.61662381 |
| 23 | CDK5 | 1.57157939 |
| 24 | UHMK1 | 1.56129830 |
| 25 | KSR1 | 1.53858776 |
| 26 | TNIK | 1.49334239 |
| 27 | GRK1 | 1.48818850 |
| 28 | GRK5 | 1.44335544 |
| 29 | PRKD3 | 1.36460434 |
| 30 | CAMK1G | 1.26701813 |
| 31 | DAPK1 | 1.26143510 |
| 32 | RIPK4 | 1.24575738 |
| 33 | CAMKK2 | 1.18956788 |
| 34 | SIK2 | 1.18199571 |
| 35 | NTRK1 | 1.15769031 |
| 36 | EPHA3 | 1.12907481 |
| 37 | ADRBK2 | 1.12168211 |
| 38 | CDK18 | 1.10079739 |
| 39 | CAMK2A | 1.09203452 |
| 40 | SGK223 | 1.07846423 |
| 41 | SGK494 | 1.07846423 |
| 42 | CAMKK1 | 1.06534851 |
| 43 | PAK3 | 1.06187131 |
| 44 | CDK15 | 1.05706831 |
| 45 | ERBB3 | 1.04769649 |
| 46 | PRPF4B | 1.04335095 |
| 47 | CDK14 | 1.01679320 |
| 48 | PRKCG | 1.00040730 |
| 49 | CCNB1 | 0.96855935 |
| 50 | CSNK1G2 | 0.96648847 |
| 51 | AKT3 | 0.95173637 |
| 52 | CDK11A | 0.93112773 |
| 53 | CAMK1 | 0.93031165 |
| 54 | CSNK1G1 | 0.92874310 |
| 55 | PTK2B | 0.92619714 |
| 56 | PRKCH | 0.92227257 |
| 57 | FES | 0.91154093 |
| 58 | CAMK2B | 0.89681680 |
| 59 | PHKG2 | 0.88255055 |
| 60 | PHKG1 | 0.88255055 |
| 61 | ACVR1B | 0.87519175 |
| 62 | SGK2 | 0.85604668 |
| 63 | STK39 | 0.83045758 |
| 64 | LATS2 | 0.82935128 |
| 65 | BCR | 0.80895614 |
| 66 | KSR2 | 0.74619401 |
| 67 | PASK | 0.73792563 |
| 68 | MKNK2 | 0.72827855 |
| 69 | SIK3 | 0.72118373 |
| 70 | MAPKAPK5 | 0.70432679 |
| 71 | STK38 | 0.68149129 |
| 72 | INSRR | 0.67661605 |
| 73 | CSNK1G3 | 0.66046811 |
| 74 | PRKCE | 0.64547001 |
| 75 | BMPR2 | 0.63782698 |
| 76 | FGR | 0.63485663 |
| 77 | LMTK2 | 0.62775293 |
| 78 | PKN1 | 0.61242809 |
| 79 | SGK1 | 0.60992156 |
| 80 | NME1 | 0.59772742 |
| 81 | DYRK1A | 0.59488663 |
| 82 | CAMK2D | 0.58130789 |
| 83 | EPHB2 | 0.56946780 |
| 84 | TAOK3 | 0.56271607 |
| 85 | STK11 | 0.55733584 |
| 86 | BMPR1B | 0.55013646 |
| 87 | SGK3 | 0.52976763 |
| 88 | ROCK2 | 0.52516503 |
| 89 | CAMK2G | 0.51017582 |
| 90 | MAP2K1 | 0.50827561 |
| 91 | ARAF | 0.50478342 |
| 92 | PRKAA1 | 0.49241699 |
| 93 | STK38L | 0.46360278 |
| 94 | TRIM28 | 0.46009807 |
| 95 | MAPK12 | 0.45979168 |
| 96 | MAPK15 | 0.45896652 |
| 97 | RET | 0.44589891 |
| 98 | PDK1 | 0.43773092 |
| 99 | NEK6 | 0.43492143 |
| 100 | CSNK1E | 0.42715117 |
| 101 | WNK3 | 0.42528155 |
| 102 | PRKCZ | 0.41761971 |
| 103 | RPS6KA3 | 0.41347522 |
| 104 | MYLK | 0.40171626 |
| 105 | FGFR2 | 0.40162729 |
| 106 | TYRO3 | 0.40131266 |
| 107 | YES1 | 0.39713786 |
| 108 | FYN | 0.39326703 |
| 109 | DAPK3 | 0.38624689 |
| 110 | PRKACB | 0.38621062 |
| 111 | PRKACA | 0.38212520 |
| 112 | PRKCB | 0.37800690 |
| 113 | MST4 | 0.37792929 |
| 114 | CAMK1D | 0.37711615 |
| 115 | FER | 0.37328468 |
| 116 | CDK3 | 0.37054122 |
| 117 | WNK4 | 0.36723882 |
| 118 | PRKD2 | 0.36242776 |
| 119 | CSNK1D | 0.35043987 |
| 120 | LIMK1 | 0.34160262 |
| 121 | ADRBK1 | 0.33854524 |
| 122 | CAMK4 | 0.33819334 |
| 123 | DYRK3 | 0.33500425 |
| 124 | PRKG1 | 0.33469509 |
| 125 | GRK7 | 0.33443196 |
| 126 | PDPK1 | 0.32851467 |
| 127 | PRKCA | 0.32328089 |
| 128 | CSNK1A1L | 0.31559518 |
| 129 | CSNK1A1 | 0.30148702 |
| 130 | MAP2K6 | 0.29457169 |
| 131 | FGFR3 | 0.28605307 |
| 132 | RPS6KA2 | 0.27739422 |
| 133 | ERBB2 | 0.27661865 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.24851329 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.87203503 |
| 3 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 3.84843425 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.87602305 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.85029082 |
| 6 | Morphine addiction_Homo sapiens_hsa05032 | 2.53996589 |
| 7 | Circadian entrainment_Homo sapiens_hsa04713 | 2.49894333 |
| 8 | Olfactory transduction_Homo sapiens_hsa04740 | 2.49142617 |
| 9 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.44691302 |
| 10 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.42008305 |
| 11 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.39643403 |
| 12 | Long-term potentiation_Homo sapiens_hsa04720 | 2.25685987 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.16785371 |
| 14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.01249485 |
| 15 | Taste transduction_Homo sapiens_hsa04742 | 1.97433971 |
| 16 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.96435672 |
| 17 | Salivary secretion_Homo sapiens_hsa04970 | 1.94437923 |
| 18 | Cocaine addiction_Homo sapiens_hsa05030 | 1.84753531 |
| 19 | Insulin secretion_Homo sapiens_hsa04911 | 1.84318604 |
| 20 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.82358014 |
| 21 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.71656948 |
| 22 | Parkinsons disease_Homo sapiens_hsa05012 | 1.61790717 |
| 23 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.60457114 |
| 24 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.59893966 |
| 25 | Renin secretion_Homo sapiens_hsa04924 | 1.58741287 |
| 26 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.58141065 |
| 27 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.57288622 |
| 28 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.56956475 |
| 29 | Long-term depression_Homo sapiens_hsa04730 | 1.54435334 |
| 30 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.50524024 |
| 31 | Alzheimers disease_Homo sapiens_hsa05010 | 1.47503440 |
| 32 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.43259458 |
| 33 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.43013599 |
| 34 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.42922373 |
| 35 | Protein export_Homo sapiens_hsa03060 | 1.39752610 |
| 36 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.31037975 |
| 37 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.29692007 |
| 38 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.29166187 |
| 39 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.24047696 |
| 40 | Axon guidance_Homo sapiens_hsa04360 | 1.23200520 |
| 41 | Gap junction_Homo sapiens_hsa04540 | 1.23067432 |
| 42 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.21753831 |
| 43 | Phototransduction_Homo sapiens_hsa04744 | 1.18635170 |
| 44 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.12525235 |
| 45 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.09128637 |
| 46 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.02982819 |
| 47 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.02976188 |
| 48 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.00004162 |
| 49 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.98709657 |
| 50 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.98166690 |
| 51 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.97888947 |
| 52 | Huntingtons disease_Homo sapiens_hsa05016 | 0.96162226 |
| 53 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.92536634 |
| 54 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.92152693 |
| 55 | Melanogenesis_Homo sapiens_hsa04916 | 0.90789004 |
| 56 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.89920160 |
| 57 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.88560026 |
| 58 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.84338524 |
| 59 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.83863995 |
| 60 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.82568685 |
| 61 | Glioma_Homo sapiens_hsa05214 | 0.82057828 |
| 62 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.81181022 |
| 63 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.79165194 |
| 64 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.77949576 |
| 65 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.76885342 |
| 66 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.75982123 |
| 67 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.72931837 |
| 68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.70893101 |
| 69 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.70505443 |
| 70 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.69019052 |
| 71 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.68750619 |
| 72 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.68195964 |
| 73 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.67980920 |
| 74 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.67270854 |
| 75 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.62548077 |
| 76 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.61606139 |
| 77 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.61278320 |
| 78 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.59319970 |
| 79 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.59221427 |
| 80 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.58828061 |
| 81 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.55408350 |
| 82 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.55070916 |
| 83 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.54915333 |
| 84 | Peroxisome_Homo sapiens_hsa04146 | 0.53640428 |
| 85 | Alcoholism_Homo sapiens_hsa05034 | 0.52493795 |
| 86 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.50657536 |
| 87 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.50506807 |
| 88 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.49755911 |
| 89 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.48292147 |
| 90 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.48195227 |
| 91 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.46912613 |
| 92 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.46646256 |
| 93 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.45488120 |
| 94 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.44433655 |
| 95 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.43954222 |
| 96 | Phagosome_Homo sapiens_hsa04145 | 0.43392506 |
| 97 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.41276893 |
| 98 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.40904665 |
| 99 | ABC transporters_Homo sapiens_hsa02010 | 0.40872408 |
| 100 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.39065859 |
| 101 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.38729489 |
| 102 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.37882771 |
| 103 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.37709236 |
| 104 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.37550939 |
| 105 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.37510205 |
| 106 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.36418192 |
| 107 | Prion diseases_Homo sapiens_hsa05020 | 0.36277325 |
| 108 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.36048139 |
| 109 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.35240591 |
| 110 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.35001299 |
| 111 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.34277016 |
| 112 | Mineral absorption_Homo sapiens_hsa04978 | 0.32263216 |
| 113 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.32226802 |
| 114 | Bile secretion_Homo sapiens_hsa04976 | 0.31932003 |
| 115 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.31645263 |
| 116 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.31597230 |
| 117 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.30371053 |
| 118 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.30273022 |
| 119 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.28268639 |
| 120 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.25511944 |
| 121 | Endocytosis_Homo sapiens_hsa04144 | 0.23501961 |
| 122 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.22752817 |
| 123 | Circadian rhythm_Homo sapiens_hsa04710 | 0.22702212 |
| 124 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.21414527 |
| 125 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.21063108 |
| 126 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.20939208 |
| 127 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.20562901 |
| 128 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.20541775 |

