TMEM198B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dermatan sulfate metabolic process (GO:0030205)6.36989204
2chondroitin sulfate catabolic process (GO:0030207)5.58929607
3dermatan sulfate biosynthetic process (GO:0030208)5.39931671
4negative regulation of astrocyte differentiation (GO:0048712)4.78615642
5positive regulation of cellular amide metabolic process (GO:0034250)4.48547867
6positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.40038442
7phagocytosis, recognition (GO:0006910)4.19918509
8outer ear morphogenesis (GO:0042473)4.16098996
9lateral sprouting from an epithelium (GO:0060601)4.10160820
10collagen fibril organization (GO:0030199)4.05694785
11mannose metabolic process (GO:0006013)3.94314206
12blood vessel maturation (GO:0001955)3.88647489
13chondrocyte proliferation (GO:0035988)3.85492736
14regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.72025022
15negative regulation of myoblast differentiation (GO:0045662)3.62867940
16histone H4 deacetylation (GO:0070933)3.52906766
17negative thymic T cell selection (GO:0045060)3.52484365
18vascular endothelial growth factor signaling pathway (GO:0038084)3.51625511
19positive thymic T cell selection (GO:0045059)3.50478670
20regulation of astrocyte differentiation (GO:0048710)3.49768541
21glomerular filtration (GO:0003094)3.44404880
22negative T cell selection (GO:0043383)3.43281640
23negative regulation of erythrocyte differentiation (GO:0045647)3.40867565
24negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.40147153
25phosphatidylglycerol biosynthetic process (GO:0006655)3.37605024
26positive regulation of CREB transcription factor activity (GO:0032793)3.33699827
27positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.33608578
28chondroitin sulfate biosynthetic process (GO:0030206)3.32169665
29histone H3 deacetylation (GO:0070932)3.27325556
30pyrimidine nucleobase catabolic process (GO:0006208)3.24082093
31phagocytosis, engulfment (GO:0006911)3.22822950
32positive regulation of endothelial cell apoptotic process (GO:2000353)3.22417574
33middle ear morphogenesis (GO:0042474)3.20205693
34negative regulation of granulocyte differentiation (GO:0030853)3.17946367
35activated T cell proliferation (GO:0050798)3.16924240
36protein heterotrimerization (GO:0070208)3.15692582
37basement membrane organization (GO:0071711)3.14511201
38detection of molecule of bacterial origin (GO:0032490)3.10411923
39glial cell migration (GO:0008347)3.08660526
40thymic T cell selection (GO:0045061)3.07717984
41positive regulation of gamma-delta T cell activation (GO:0046645)3.06441131
42positive regulation of histone deacetylation (GO:0031065)3.04282940
43positive T cell selection (GO:0043368)3.03705097
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03399676
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.03399676
46modulation by symbiont of host immune response (GO:0052553)3.03399676
47positive regulation by symbiont of host defense response (GO:0052509)3.03399676
48modulation by symbiont of host defense response (GO:0052031)3.03399676
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03399676
50endodermal cell differentiation (GO:0035987)3.02379596
51negative regulation of platelet activation (GO:0010544)3.02258145
52cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.01707460
53establishment of mitochondrion localization (GO:0051654)3.01126638
54daunorubicin metabolic process (GO:0044597)2.98458404
55polyketide metabolic process (GO:0030638)2.98458404
56doxorubicin metabolic process (GO:0044598)2.98458404
57collagen metabolic process (GO:0032963)2.96684731
58regulation of granulocyte differentiation (GO:0030852)2.96242776
59cellular response to cholesterol (GO:0071397)2.96019135
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.95362887
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94601839
62regulation of gamma-delta T cell differentiation (GO:0045586)2.94346220
63collagen catabolic process (GO:0030574)2.93349921
64sequestering of extracellular ligand from receptor (GO:0035581)2.91567560
65negative regulation of heart growth (GO:0061117)2.89962405
66negative regulation of cardiac muscle tissue growth (GO:0055022)2.89962405
67cilium or flagellum-dependent cell motility (GO:0001539)2.88764073
68renal filtration (GO:0097205)2.87580714
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86583798
70mesenchymal-epithelial cell signaling (GO:0060638)2.86192871
71positive regulation of granulocyte differentiation (GO:0030854)2.85914193
72histone H3-K4 trimethylation (GO:0080182)2.82462186
73alanine transport (GO:0032328)2.80867646
74regulation of gamma-delta T cell activation (GO:0046643)2.78413862
75response to laminar fluid shear stress (GO:0034616)2.77447874
76microglial cell activation (GO:0001774)2.77396536
77response to fluid shear stress (GO:0034405)2.76185095
78T cell selection (GO:0045058)2.76151984
79embryonic skeletal joint morphogenesis (GO:0060272)2.75736050
80regulation of collagen metabolic process (GO:0010712)2.74644936
81response to misfolded protein (GO:0051788)2.74363294
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.73952827
83mitochondrion transport along microtubule (GO:0047497)2.73952827
84negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.72151878
85branching involved in salivary gland morphogenesis (GO:0060445)2.72029215
86somatic stem cell division (GO:0048103)2.70746845
87head development (GO:0060322)2.70292846
88epithelial cilium movement (GO:0003351)2.69994806
89apoptotic cell clearance (GO:0043277)2.68985155
90positive regulation of astrocyte differentiation (GO:0048711)2.68906944
91positive regulation of collagen biosynthetic process (GO:0032967)2.68751398
92negative regulation of cAMP-mediated signaling (GO:0043951)2.68622176
93cell proliferation involved in metanephros development (GO:0072203)2.68601360
94wound healing, spreading of epidermal cells (GO:0035313)2.67973030
95histone H3-K9 modification (GO:0061647)2.67839600
96endothelium development (GO:0003158)2.67520883
97regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.66925075
98astrocyte differentiation (GO:0048708)2.66559379
99cell migration involved in heart development (GO:0060973)2.66397755
100Notch signaling involved in heart development (GO:0061314)2.65725023
101multicellular organismal macromolecule metabolic process (GO:0044259)2.65124377
102regulation of hydrogen peroxide metabolic process (GO:0010310)2.64750342
103regulation of ARF GTPase activity (GO:0032312)2.64289219
104adhesion of symbiont to host (GO:0044406)2.63609558
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63499566
106wound healing, spreading of cells (GO:0044319)2.62655816
107cellular response to exogenous dsRNA (GO:0071360)2.62505208
108positive regulation of protein kinase C signaling (GO:0090037)2.60956463
109glomerular basement membrane development (GO:0032836)2.58226399
110negative regulation of smoothened signaling pathway (GO:0045879)2.58217270
111ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.57916166
112positive regulation of collagen metabolic process (GO:0010714)2.57878630
113positive regulation of epithelial to mesenchymal transition (GO:0010718)2.56779844
114regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.54855668
115multicellular organismal catabolic process (GO:0044243)2.54413991
116retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54381772
117left/right pattern formation (GO:0060972)2.54063702
118postsynaptic membrane organization (GO:0001941)2.53799057
119regulation of respiratory system process (GO:0044065)2.52997087
120glycosaminoglycan catabolic process (GO:0006027)2.52638492
121negative regulation of glial cell differentiation (GO:0045686)2.52304331
122embryonic cranial skeleton morphogenesis (GO:0048701)2.51826689
123response to cholesterol (GO:0070723)2.50712412
124regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.50517775
125extracellular fibril organization (GO:0043206)2.50478761
126negative regulation of osteoblast proliferation (GO:0033689)2.49920335
127regulation of collagen biosynthetic process (GO:0032965)2.49641960
128cell migration in hindbrain (GO:0021535)2.48901759
129positive regulation of extracellular matrix organization (GO:1903055)2.48190037
130negative regulation of mast cell activation (GO:0033004)2.47097406
131negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.46055545
132cilium movement (GO:0003341)2.45890510
133regulation of monocyte chemotaxis (GO:0090025)2.45869062
134ovulation cycle (GO:0042698)2.45282724
135aminoglycan catabolic process (GO:0006026)2.45147023
136chondroitin sulfate metabolic process (GO:0030204)2.44544719
137nuclear envelope reassembly (GO:0031468)2.42855095
138mitotic nuclear envelope reassembly (GO:0007084)2.42855095
139positive regulation of Rab GTPase activity (GO:0032851)2.42757215
140regulation of Rab GTPase activity (GO:0032313)2.42757215
141multicellular organismal metabolic process (GO:0044236)2.42267818
142virion attachment to host cell (GO:0019062)2.41282226
143adhesion of symbiont to host cell (GO:0044650)2.41282226
144negative regulation of cardiac muscle tissue development (GO:0055026)2.40691601
145substrate-independent telencephalic tangential migration (GO:0021826)2.38866605
146substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.38866605
147negative regulation of glial cell proliferation (GO:0060253)2.37356381
148seminiferous tubule development (GO:0072520)2.35281454
149Arp2/3 complex-mediated actin nucleation (GO:0034314)2.34178094
150positive regulation of B cell differentiation (GO:0045579)2.34048897
151histone H3-K9 methylation (GO:0051567)2.33938630
152neuronal ion channel clustering (GO:0045161)2.32131543
153axoneme assembly (GO:0035082)2.31593120
154cell-cell junction maintenance (GO:0045217)2.30245103
155response to muramyl dipeptide (GO:0032495)2.25395989
156regulation of histone deacetylation (GO:0031063)2.24860764
157nucleobase catabolic process (GO:0046113)2.23223902
158motile cilium assembly (GO:0044458)2.22515511
159negative regulation of interleukin-8 production (GO:0032717)2.19892355
160UV protection (GO:0009650)2.14512627
161regulation of cilium movement (GO:0003352)2.11485887
162maintenance of protein location in nucleus (GO:0051457)2.11166100
163regulation of cilium assembly (GO:1902017)2.10467764
164negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.07888448
165neurotransmitter catabolic process (GO:0042135)2.05423640
166regulation of microtubule-based movement (GO:0060632)2.04908426
167tongue development (GO:0043586)2.04655736
168cranial nerve morphogenesis (GO:0021602)2.03411152
169regulation of T-helper 2 cell differentiation (GO:0045628)2.02803699
170positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.02251492
171mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.02251492
172regulation of dendritic cell antigen processing and presentation (GO:0002604)2.01051471
173central nervous system myelination (GO:0022010)2.01024922
174axon ensheathment in central nervous system (GO:0032291)2.01024922
175positive regulation of gastrulation (GO:2000543)2.00661447
176axonemal dynein complex assembly (GO:0070286)1.99679031
177poly(A)+ mRNA export from nucleus (GO:0016973)1.99663316
178viral transcription (GO:0019083)1.98975894
179RNA destabilization (GO:0050779)1.96312271
180sequestering of actin monomers (GO:0042989)1.96206852
181positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003601.96033503
182urinary tract smooth muscle contraction (GO:0014848)1.95805673
183endothelial cell chemotaxis (GO:0035767)1.95157883
184positive regulation of protein deacetylation (GO:0090312)1.95076141
185modulation by virus of host process (GO:0019054)1.94842345
186regulation of B cell differentiation (GO:0045577)1.94627762
187nonmotile primary cilium assembly (GO:0035058)1.94336482
188regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.93533298
189positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)1.93311067
190natural killer cell differentiation (GO:0001779)1.93240174
191positive regulation of synaptic transmission, glutamatergic (GO:0051968)1.93110950
192regulation of monocyte differentiation (GO:0045655)1.92824998
193negative regulation of type 2 immune response (GO:0002829)1.92169552
194leukocyte aggregation (GO:0070486)1.90929568
195negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)1.90115299
196negative regulation of interleukin-6 production (GO:0032715)1.88882693
197neuronal stem cell maintenance (GO:0097150)1.87555856
198positive regulation of antigen processing and presentation (GO:0002579)1.87324134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.39678202
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.79865625
3EZH2_22144423_ChIP-Seq_EOC_Human4.54591818
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.79402195
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.66858928
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.46852385
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.40748284
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.26755013
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.06150729
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.75300663
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.57396204
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.56925067
13VDR_21846776_ChIP-Seq_THP-1_Human2.46947838
14CLOCK_20551151_ChIP-Seq_293T_Human2.46553178
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44242555
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43726677
17LXR_22292898_ChIP-Seq_THP-1_Human2.42321372
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.39700724
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.31694759
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.30833604
21TP53_20018659_ChIP-ChIP_R1E_Mouse2.29660874
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.27998613
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.27945088
24SCL_19346495_ChIP-Seq_HPC-7_Human2.22055265
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.18799869
26DROSHA_22980978_ChIP-Seq_HELA_Human2.17589230
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.08141902
28KDM2B_26808549_Chip-Seq_DND41_Human1.98074017
29P68_20966046_ChIP-Seq_HELA_Human1.94817283
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.92592218
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.92124157
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90403529
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90224405
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89741845
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.89384667
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.87321619
37CJUN_26792858_Chip-Seq_BT549_Human1.86706534
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.86576808
39BRD4_25478319_ChIP-Seq_HGPS_Human1.86289662
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85216522
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85039213
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84963344
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83745869
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82736603
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.80864098
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80252112
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79391414
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.78759791
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75977531
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74203471
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73457162
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72050598
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71626313
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68182153
55CTCF_27219007_Chip-Seq_Bcells_Human1.67917184
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65573676
57SMC4_20622854_ChIP-Seq_HELA_Human1.64120659
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63681409
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.57438042
60UTX_26944678_Chip-Seq_JUKART_Human1.56696724
61TCF7_22412390_ChIP-Seq_EML_Mouse1.54413366
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53975560
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.53945927
64MYC_22102868_ChIP-Seq_BL_Human1.53032445
65PHF8_20622854_ChIP-Seq_HELA_Human1.52313379
66AR_21572438_ChIP-Seq_LNCaP_Human1.51488192
67MAF_26560356_Chip-Seq_TH2_Human1.49314386
68* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48558278
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.48046171
70EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46580730
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.46571368
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.45619898
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45582137
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45582137
75KDM2B_26808549_Chip-Seq_K562_Human1.45427431
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44757034
77BCOR_27268052_Chip-Seq_Bcells_Human1.43581323
78E2F1_20622854_ChIP-Seq_HELA_Human1.41491255
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41431729
80TP53_18474530_ChIP-ChIP_U2OS_Human1.40985575
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40983875
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39410499
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38669646
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.38516056
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37762646
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36825898
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35275356
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34336676
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.34044469
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33904210
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32927057
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32927057
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.31817750
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.31377186
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31247593
96MAF_26560356_Chip-Seq_TH1_Human1.26805647
97TP63_22573176_ChIP-Seq_HFKS_Human1.26700958
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26439162
99OCT4_19829295_ChIP-Seq_ESCs_Human1.25234667
100CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25214759
101ERA_21632823_ChIP-Seq_H3396_Human1.25075191
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24744256
103CREB1_26743006_Chip-Seq_LNCaP_Human1.24524671
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23324113
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23287823
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22659768
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21752776
108RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21678284
109RUNX_20019798_ChIP-Seq_JUKART_Human1.21381423
110VDR_24787735_ChIP-Seq_THP-1_Human1.20983485
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.20606357
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20387362
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.20282877
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20121218
115SA1_27219007_Chip-Seq_Bcells_Human1.17911537
116CTCF_20526341_ChIP-Seq_ESCs_Human1.17163589
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17090702
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14749280
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13289016
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13042416
121GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12351610
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10731823
123ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10621370
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10214069
125TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09116847
126SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09034857
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08620042
128KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08614709
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08497829
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08410441
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07564528
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07112776
133SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06591071
134REST_21632747_ChIP-Seq_MESCs_Mouse1.06057625
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06055435
136JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04999632
137ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04019544
138NFI_21473784_ChIP-Seq_ESCs_Mouse1.03842136
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02622834
140P300_27268052_Chip-Seq_Bcells_Human1.01845631
141BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01315841
142RNF2_27304074_Chip-Seq_ESCs_Mouse1.00940272
143OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99402495
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99082971
145TP53_22127205_ChIP-Seq_IMR90_Human0.98863637
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98242886
147SA1_22415368_ChIP-Seq_MEFs_Mouse0.98107764
148GATA2_21666600_ChIP-Seq_HMVEC_Human0.97951945
149SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96628196
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96479047
151ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96430878
152SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96253533
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95928069
154RARB_24833708_ChIP-Seq_LIVER_Mouse0.95643188
155JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95290965
156KLF4_19829295_ChIP-Seq_ESCs_Human0.95127356
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.95018171
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94820266
159MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93647130
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93564377
161SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93564377
162REST_18959480_ChIP-ChIP_MESCs_Mouse0.93539091
163CBX2_27304074_Chip-Seq_ESCs_Mouse0.93434764
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91866096
165CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90838927
166SPI1_23127762_ChIP-Seq_K562_Human0.90777458
167CIITA_25753668_ChIP-Seq_RAJI_Human0.90588107
168VDR_24763502_ChIP-Seq_THP-1_Human0.89445695
169RUNX1_27514584_Chip-Seq_MCF-7_Human0.89101166
170EZH2_27304074_Chip-Seq_ESCs_Mouse0.88961673
171RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88688036
172BCL6_27268052_Chip-Seq_Bcells_Human0.88440092
173RING1B_27294783_Chip-Seq_ESCs_Mouse0.88423755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.81337205
2MP0005503_abnormal_tendon_morphology5.39127508
3MP0001958_emphysema3.45565549
4MP0003279_aneurysm3.39682029
5MP0003880_abnormal_central_pattern2.88301753
6MP0005171_absent_coat_pigmentation2.68411788
7MP0003436_decreased_susceptibility_to2.61950614
8MP0002822_catalepsy2.58937659
9MP0010368_abnormal_lymphatic_system2.56902828
10MP0009384_cardiac_valve_regurgitation2.51211313
11MP0005508_abnormal_skeleton_morphology2.46449748
12MP0002282_abnormal_trachea_morphology2.39056360
13MP0005275_abnormal_skin_tensile2.23057658
14MP0000049_abnormal_middle_ear2.20642431
15MP0000537_abnormal_urethra_morphology2.20638277
16MP0000767_abnormal_smooth_muscle2.15599961
17MP0003941_abnormal_skin_development2.12805978
18MP0010030_abnormal_orbit_morphology2.09388948
19MP0009053_abnormal_anal_canal2.05719073
20MP0003705_abnormal_hypodermis_morpholog1.99710413
21MP0003787_abnormal_imprinting1.95071757
22MP0003011_delayed_dark_adaptation1.88064662
23MP0009250_abnormal_appendicular_skeleto1.80468029
24MP0004859_abnormal_synaptic_plasticity1.76674355
25MP0002108_abnormal_muscle_morphology1.74699511
26MP0003690_abnormal_glial_cell1.74148691
27MP0003091_abnormal_cell_migration1.72231929
28MP0000428_abnormal_craniofacial_morphol1.70201944
29MP0002249_abnormal_larynx_morphology1.68422348
30MP0005390_skeleton_phenotype1.68319843
31MP0004272_abnormal_basement_membrane1.68014858
32MP0005499_abnormal_olfactory_system1.65621495
33MP0005394_taste/olfaction_phenotype1.65621495
34MP0003136_yellow_coat_color1.64078633
35MP0005670_abnormal_white_adipose1.62290860
36MP0000733_abnormal_muscle_development1.60051966
37MP0008995_early_reproductive_senescence1.54949774
38MP0001986_abnormal_taste_sensitivity1.51795259
39MP0001800_abnormal_humoral_immune1.51574395
40MP0005623_abnormal_meninges_morphology1.50023353
41MP0001542_abnormal_bone_strength1.49130217
42MP0006276_abnormal_autonomic_nervous1.48887959
43MP0000778_abnormal_nervous_system1.47375220
44MP0005058_abnormal_lysosome_morphology1.46883012
45MP0006054_spinal_hemorrhage1.44057511
46MP0005025_abnormal_response_to1.40980664
47MP0002089_abnormal_postnatal_growth/wei1.40307034
48MP0008789_abnormal_olfactory_epithelium1.37669375
49MP0001790_abnormal_immune_system1.37600769
50MP0005387_immune_system_phenotype1.37600769
51MP0001879_abnormal_lymphatic_vessel1.35661305
52MP0001545_abnormal_hematopoietic_system1.34067906
53MP0005397_hematopoietic_system_phenotyp1.34067906
54MP0001502_abnormal_circadian_rhythm1.33791794
55MP0008007_abnormal_cellular_replicative1.31445183
56MP0005257_abnormal_intraocular_pressure1.31082615
57MP0001835_abnormal_antigen_presentation1.31050955
58MP0004133_heterotaxia1.30697326
59MP0009840_abnormal_foam_cell1.29982747
60MP0000163_abnormal_cartilage_morphology1.29059070
61MP0000467_abnormal_esophagus_morphology1.27316747
62MP0002419_abnormal_innate_immunity1.27015102
63MP0003385_abnormal_body_wall1.25109393
64MP0003566_abnormal_cell_adhesion1.24311204
65MP0002295_abnormal_pulmonary_circulatio1.23686090
66MP0009379_abnormal_foot_pigmentation1.23080019
67MP0002254_reproductive_system_inflammat1.22971918
68MP0001533_abnormal_skeleton_physiology1.22031368
69MP0002933_joint_inflammation1.20574282
70MP0001299_abnormal_eye_distance/1.20453246
71MP0005671_abnormal_response_to1.20040448
72MP0002132_abnormal_respiratory_system1.18936479
73MP0002723_abnormal_immune_serum1.17855200
74MP0003937_abnormal_limbs/digits/tail_de1.17765912
75MP0002932_abnormal_joint_morphology1.17350543
76MP0005535_abnormal_body_temperature1.17294298
77MP0000858_altered_metastatic_potential1.16837349
78MP0004858_abnormal_nervous_system1.16106277
79MP0000026_abnormal_inner_ear1.14976432
80MP0005000_abnormal_immune_tolerance1.14734104
81MP0002420_abnormal_adaptive_immunity1.13590338
82MP0005365_abnormal_bile_salt1.12928951
83MP0003115_abnormal_respiratory_system1.11862381
84MP0004130_abnormal_muscle_cell1.11674756
85MP0001819_abnormal_immune_cell1.10536658
86MP0003172_abnormal_lysosome_physiology1.09909214
87MP0001175_abnormal_lung_morphology1.08703323
88MP0005551_abnormal_eye_electrophysiolog1.08492158
89MP0003942_abnormal_urinary_system1.07922602
90MP0003303_peritoneal_inflammation1.06863233
91MP0003075_altered_response_to1.06170164
92MP0001915_intracranial_hemorrhage1.05994649
93MP0001970_abnormal_pain_threshold1.05407026
94MP0000343_altered_response_to1.04928010
95MP0002060_abnormal_skin_morphology1.04147201
96MP0003329_amyloid_beta_deposits1.02793238
97MP0004134_abnormal_chest_morphology1.02369914
98MP0002998_abnormal_bone_remodeling1.02079515
99MP0000604_amyloidosis1.01782876
100MP0002116_abnormal_craniofacial_bone1.01115247
101MP0000432_abnormal_head_morphology0.98910829
102MP0002405_respiratory_system_inflammati0.98203501
103MP0001764_abnormal_homeostasis0.98091616
104MP0002063_abnormal_learning/memory/cond0.96638655
105MP0003755_abnormal_palate_morphology0.95578193
106MP0008961_abnormal_basal_metabolism0.95188748
107MP0002115_abnormal_skeleton_extremities0.95114168
108MP0001614_abnormal_blood_vessel0.94861128
109MP0001486_abnormal_startle_reflex0.94764671
110MP0000955_abnormal_spinal_cord0.94477906
111MP0008260_abnormal_autophagy0.94239517
112MP0002735_abnormal_chemical_nociception0.92749261
113MP0002128_abnormal_blood_circulation0.92735735
114MP0002113_abnormal_skeleton_development0.92626308
115MP0005646_abnormal_pituitary_gland0.92552581
116MP0001968_abnormal_touch/_nociception0.92142965
117MP0005164_abnormal_response_to0.92088948
118MP0003448_altered_tumor_morphology0.92024092
119MP0002109_abnormal_limb_morphology0.91345843
120MP0005410_abnormal_fertilization0.91266251
121MP0003763_abnormal_thymus_physiology0.91262357
122MP0002177_abnormal_outer_ear0.90570602
123MP0004883_abnormal_blood_vessel0.89541100
124MP0002557_abnormal_social/conspecific_i0.89538045
125MP0002638_abnormal_pupillary_reflex0.88550513
126MP0009764_decreased_sensitivity_to0.88200263
127MP0002733_abnormal_thermal_nociception0.87342929
128MP0006082_CNS_inflammation0.87301295
129MP0000716_abnormal_immune_system0.86204061
130MP0000566_synostosis0.86037172
131MP0003635_abnormal_synaptic_transmissio0.84638943
132MP0002148_abnormal_hypersensitivity_rea0.84489545
133MP0002452_abnormal_antigen_presenting0.84220362
134MP0003878_abnormal_ear_physiology0.84073607
135MP0005377_hearing/vestibular/ear_phenot0.84073607
136MP0003950_abnormal_plasma_membrane0.83930433
137MP0003724_increased_susceptibility_to0.83561288
138MP0004142_abnormal_muscle_tone0.83354143
139MP0005666_abnormal_adipose_tissue0.82788841
140MP0002882_abnormal_neuron_morphology0.82536314
141MP0001853_heart_inflammation0.82040371
142MP0002653_abnormal_ependyma_morphology0.81942699
143MP0008875_abnormal_xenobiotic_pharmacok0.81374516
144MP0009115_abnormal_fat_cell0.81188267
145MP0005423_abnormal_somatic_nervous0.80072429
146MP0004742_abnormal_vestibular_system0.79917909
147MP0002572_abnormal_emotion/affect_behav0.79121177
148MP0005388_respiratory_system_phenotype0.79029819
149MP0002133_abnormal_respiratory_system0.79029819
150MP0005448_abnormal_energy_balance0.78747330
151MP0005023_abnormal_wound_healing0.77676444
152MP0002752_abnormal_somatic_nervous0.76203489
153MP0001501_abnormal_sleep_pattern0.75954827
154MP0002928_abnormal_bile_duct0.75413592
155MP0009278_abnormal_bone_marrow0.75094183
156MP0009697_abnormal_copulation0.74777814
157MP0001663_abnormal_digestive_system0.74733768
158MP0000685_abnormal_immune_system0.73950888
159MP0003935_abnormal_craniofacial_develop0.73742491
160MP0003634_abnormal_glial_cell0.73315461
161MP0002233_abnormal_nose_morphology0.72958538
162MP0002938_white_spotting0.72808531
163MP0004043_abnormal_pH_regulation0.72535120
164MP0003300_gastrointestinal_ulcer0.71908727
165MP0001905_abnormal_dopamine_level0.71740325
166MP0003828_pulmonary_edema0.70820722
167MP0002398_abnormal_bone_marrow0.70767298
168MP0005084_abnormal_gallbladder_morpholo0.70176368
169MP0003938_abnormal_ear_development0.70013987
170MP0006292_abnormal_olfactory_placode0.68948731
171MP0004381_abnormal_hair_follicle0.68679661
172MP0009765_abnormal_xenobiotic_induced0.67844659
173MP0010155_abnormal_intestine_physiology0.66012005
174MP0005083_abnormal_biliary_tract0.65974931

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.33389768
2Protrusio acetabuli (HP:0003179)4.68871660
3Cervical subluxation (HP:0003308)4.43231544
4Biconcave vertebral bodies (HP:0004586)3.85085234
5Humeroradial synostosis (HP:0003041)3.50924829
6Synostosis involving the elbow (HP:0003938)3.50924829
7Panhypogammaglobulinemia (HP:0003139)3.41418337
8Tubulointerstitial nephritis (HP:0001970)3.37802244
9Agammaglobulinemia (HP:0004432)3.35614299
10Neonatal short-limb short stature (HP:0008921)3.31579199
11Shallow orbits (HP:0000586)3.27783648
12Morphological abnormality of the middle ear (HP:0008609)3.27780223
13Abnormality of the distal phalanges of the toes (HP:0010182)3.25473388
14Anomalous pulmonary venous return (HP:0010772)3.17159792
15Chronic hepatic failure (HP:0100626)3.10626422
16Aortic dissection (HP:0002647)3.07669014
17Elevated erythrocyte sedimentation rate (HP:0003565)3.03396792
18Vertebral compression fractures (HP:0002953)3.02783845
19Papilledema (HP:0001085)2.88434639
20Ankle contracture (HP:0006466)2.88171378
21Tarsal synostosis (HP:0008368)2.87597262
22Soft skin (HP:0000977)2.85037509
23Abnormality of the proximal phalanges of the hand (HP:0009834)2.84817929
24Patent foramen ovale (HP:0001655)2.81240923
25Occipital encephalocele (HP:0002085)2.76705157
26Broad face (HP:0000283)2.74457296
27Aortic regurgitation (HP:0001659)2.73119419
28Severe visual impairment (HP:0001141)2.70872264
29Synostosis involving bones of the lower limbs (HP:0009138)2.68483556
30Synostosis involving bones of the feet (HP:0009140)2.68483556
31Broad metatarsal (HP:0001783)2.66393652
32Adactyly (HP:0009776)2.65653173
33Colitis (HP:0002583)2.63072145
34Abnormality of dentin (HP:0010299)2.60642355
35Abnormality of the pulmonary veins (HP:0011718)2.60377780
36Follicular hyperkeratosis (HP:0007502)2.57156617
37Aplasia/Hypoplasia of the clavicles (HP:0006710)2.56770587
38Atelectasis (HP:0100750)2.53417358
39Retinal dysplasia (HP:0007973)2.50883216
40Bladder diverticulum (HP:0000015)2.50357933
41Obstructive sleep apnea (HP:0002870)2.49719304
42Bronchomalacia (HP:0002780)2.49289192
43Myositis (HP:0100614)2.48920044
44Abnormality of the nasal septum (HP:0000419)2.47374900
45Short hallux (HP:0010109)2.47286322
46Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.41866322
47Osteolytic defects of the hand bones (HP:0009699)2.41365315
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.41365315
49Aplasia/Hypoplasia of the hallux (HP:0008362)2.41053038
50Abnormality of the middle phalanges of the toes (HP:0010183)2.41047118
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40657170
52Short nail (HP:0001799)2.35645472
53Megalencephaly (HP:0001355)2.34351417
54Abnormality of the fingertips (HP:0001211)2.32365784
55Eczematoid dermatitis (HP:0000976)2.31513840
56Adrenal hypoplasia (HP:0000835)2.30903403
57Peritonitis (HP:0002586)2.29139569
58Mesangial abnormality (HP:0001966)2.28981464
59Dilatation of the ascending aorta (HP:0005111)2.28931499
60Nephronophthisis (HP:0000090)2.28865985
61Short clavicles (HP:0000894)2.28729727
62Cerebral aneurysm (HP:0004944)2.26448618
63Mitral regurgitation (HP:0001653)2.24284582
64Prostate neoplasm (HP:0100787)2.22650633
65Sleep apnea (HP:0010535)2.22306391
66Abnormality of skull ossification (HP:0002703)2.20530823
67Abnormal rod and cone electroretinograms (HP:0008323)2.20415067
68Supernumerary ribs (HP:0005815)2.19575495
69Dysostosis multiplex (HP:0000943)2.19046356
70Blue sclerae (HP:0000592)2.18688230
71Gastrointestinal inflammation (HP:0004386)2.18317741
72Systemic lupus erythematosus (HP:0002725)2.16719059
73Abnormal respiratory epithelium morphology (HP:0012253)2.16570597
74Abnormal respiratory motile cilium morphology (HP:0005938)2.16570597
75Genetic anticipation (HP:0003743)2.14376105
76Hypoplastic ischia (HP:0003175)2.14148723
77Synostosis of carpal bones (HP:0005048)2.13809965
78Decreased skull ossification (HP:0004331)2.13738380
79Atrophic scars (HP:0001075)2.11686788
80Broad distal phalanx of finger (HP:0009836)2.11469096
81Supernumerary bones of the axial skeleton (HP:0009144)2.11271105
82Mucopolysacchariduria (HP:0008155)2.10560060
83Urinary glycosaminoglycan excretion (HP:0003541)2.10560060
84Seborrheic dermatitis (HP:0001051)2.09811712
85Abnormality of the right ventricle (HP:0001707)2.09548569
86Fused cervical vertebrae (HP:0002949)2.05765935
87Joint stiffness (HP:0001387)2.05329090
88Abnormal delayed hypersensitivity skin test (HP:0002963)2.04668564
89Aplasia involving bones of the extremities (HP:0009825)2.04306648
90Aplasia involving bones of the upper limbs (HP:0009823)2.04306648
91Aplasia of the phalanges of the hand (HP:0009802)2.04306648
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03435648
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03435648
94Abnormality of polysaccharide metabolism (HP:0011012)2.03435648
95Dynein arm defect of respiratory motile cilia (HP:0012255)2.02762582
96Absent/shortened dynein arms (HP:0200106)2.02762582
97Wormian bones (HP:0002645)2.02712847
98Thoracic kyphosis (HP:0002942)2.02627629
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02294385
100Coronal craniosynostosis (HP:0004440)2.02039904
101J-shaped sella turcica (HP:0002680)2.01922331
102Ankle clonus (HP:0011448)2.00410963
103Supranuclear gaze palsy (HP:0000605)2.00091324
104Renal dysplasia (HP:0000110)1.99547529
105Obstructive lung disease (HP:0006536)1.99510879
106Chronic obstructive pulmonary disease (HP:0006510)1.99510879
107Meningitis (HP:0001287)1.99027902
108Gait imbalance (HP:0002141)1.98812659
109Prolonged bleeding time (HP:0003010)1.98059176
110Aortic valve stenosis (HP:0001650)1.97673404
111Abnormality of the renal medulla (HP:0100957)1.96419443
112Inflammation of the large intestine (HP:0002037)1.96181080
113Spinal cord lesions (HP:0100561)1.95976770
114Syringomyelia (HP:0003396)1.95976770
115Broad hallux (HP:0010055)1.95672430
116Long nose (HP:0003189)1.93658609
117Carpal synostosis (HP:0009702)1.93471456
118Pulmonary artery stenosis (HP:0004415)1.92422715
119Medial flaring of the eyebrow (HP:0010747)1.90570371
120Vitreoretinal degeneration (HP:0000655)1.90118202
121Complement deficiency (HP:0004431)1.89076313
122Nephrogenic diabetes insipidus (HP:0009806)1.88575586
123Neoplasm of the heart (HP:0100544)1.87885916
124Cerebral palsy (HP:0100021)1.86391558
125Abnormality of lateral ventricle (HP:0030047)1.85920388
126Abnormality of the aortic arch (HP:0012303)1.85849689
127Abnormality of the pubic bones (HP:0003172)1.85484389
128Flared iliac wings (HP:0002869)1.85360566
129Broad toe (HP:0001837)1.85001336
130Narrow nasal bridge (HP:0000446)1.84006948
131Abnormal delivery (HP:0001787)1.83640160
132Recurrent gram-negative bacterial infections (HP:0005420)1.82854558
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.82665638
134Increased IgE level (HP:0003212)1.82141289
135Congenital primary aphakia (HP:0007707)1.81931259
136Absent toe (HP:0010760)1.81421467
137Abnormal ciliary motility (HP:0012262)1.80692215
138Tubulointerstitial abnormality (HP:0001969)1.80679137
139Progressive cerebellar ataxia (HP:0002073)1.80582266
140Hyperextensible skin (HP:0000974)1.80046741
141White forelock (HP:0002211)1.79871059
142Hypoplasia of the odontoid process (HP:0003311)1.79499707
143Cellulitis (HP:0100658)1.79422350
144Patchy hypopigmentation of hair (HP:0011365)1.78353738
145Asplenia (HP:0001746)1.77902518
146Cystic liver disease (HP:0006706)1.77443009
147Congenital stationary night blindness (HP:0007642)1.77124628
148Retinal atrophy (HP:0001105)1.76929810
149Broad long bones (HP:0005622)1.75259663
150Spinal canal stenosis (HP:0003416)1.75101287
151Stage 5 chronic kidney disease (HP:0003774)1.74919937
152Stridor (HP:0010307)1.74574012
153Attenuation of retinal blood vessels (HP:0007843)1.74053359
154Turricephaly (HP:0000262)1.73556073
155Abnormality of the humeroradial joint (HP:0100744)1.72864781
156Spinal rigidity (HP:0003306)1.72743916
157True hermaphroditism (HP:0010459)1.72729684
158Annular pancreas (HP:0001734)1.72658230
159Abnormality of the thoracic spine (HP:0100711)1.72301770
160Stomatitis (HP:0010280)1.72229856
161Hand muscle atrophy (HP:0009130)1.71711700
162Optic nerve coloboma (HP:0000588)1.71263229
163Failure to thrive in infancy (HP:0001531)1.70512001
164Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.69810889
165Abnormality of midbrain morphology (HP:0002418)1.69371970
166Molar tooth sign on MRI (HP:0002419)1.69371970
167Abnormal finger flexion creases (HP:0006143)1.69246609
168Submucous cleft hard palate (HP:0000176)1.68903133
169Conical tooth (HP:0000698)1.68152311
170Abnormality of the phalanges of the 5th finger (HP:0004213)1.67489668
171Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67333623
172Abnormality of the odontoid process (HP:0003310)1.67316328
173Type II lissencephaly (HP:0007260)1.67101993
174Bell-shaped thorax (HP:0001591)1.66820414
175Facial shape deformation (HP:0011334)1.66361523
176Potter facies (HP:0002009)1.66361523
177Bony spicule pigmentary retinopathy (HP:0007737)1.65355450
178Natal tooth (HP:0000695)1.64069678
179Infantile muscular hypotonia (HP:0008947)1.64056744
180Dislocated radial head (HP:0003083)1.63283173
181Fragile skin (HP:0001030)1.62907316
182Joint laxity (HP:0001388)1.62872498
183Increased number of teeth (HP:0011069)1.62714399
184Back pain (HP:0003418)1.61481274
185Deformed sella turcica (HP:0002681)1.60651388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.04508372
2MAP3K142.86910912
3EPHB22.86800721
4ICK2.76277045
5IRAK32.67786433
6PDGFRA2.67220212
7BMPR1B2.49456797
8TNK22.49346281
9BMX2.40613830
10DDR22.36772770
11SIK22.28801683
12MARK22.22930397
13PHKG12.22319057
14PHKG22.22319057
15MAP4K12.15940533
16BLK2.13848308
17TGFBR22.13061999
18TRPM71.94898256
19KIT1.78003518
20SIK11.77448057
21DYRK1B1.72228860
22TYRO31.71523635
23TRIB31.70640252
24YES11.70154690
25TTN1.63271775
26MAP3K71.63231567
27ZAP701.49287982
28CHUK1.46791828
29SIK31.45085962
30GRK61.44004463
31TNIK1.35865870
32RPS6KA21.32113733
33ERN11.30963983
34EPHB11.30743612
35MKNK11.29974079
36NTRK21.29208307
37CASK1.28949863
38MAPK151.28940556
39TESK21.26113066
40PRPF4B1.26096845
41HIPK21.23238699
42MAP3K111.21220635
43IRAK41.18571712
44MARK11.18105517
45FES1.17129166
46RPS6KC11.16580713
47RPS6KL11.16580713
48MET1.14480545
49FLT31.13905423
50BTK1.13629210
51MAP2K31.12083443
52MAP3K61.10884668
53TBK11.08892270
54IKBKB1.05754522
55ITK1.05745279
56IRAK21.05575037
57CDC42BPA1.05093742
58CSF1R1.04186357
59LMTK21.03839867
60CDK121.03724255
61JAK31.01762180
62TGFBR11.01032127
63MAP2K61.00173709
64LATS20.99994434
65MAPK120.99772317
66PAK20.97737327
67TAOK30.96671070
68NTRK30.96495173
69CAMKK10.96279665
70PRKD30.96064363
71RIPK40.95537165
72TYK20.93507813
73ZAK0.92775408
74SYK0.91364414
75PDGFRB0.90917088
76BCKDK0.90137837
77DMPK0.88265374
78UHMK10.88158147
79MARK30.87714877
80PTK60.87454035
81PRKCH0.86771368
82SGK20.85516595
83ERBB30.85287366
84MAP2K40.84882925
85FGFR20.84560495
86DYRK1A0.83463431
87PIM20.83452863
88WNK40.79362237
89INSRR0.79162801
90PRKD20.79023004
91TXK0.77952965
92KDR0.76611676
93EPHA20.76183489
94MAP2K20.74396482
95PBK0.73896817
96MAPK70.72489504
97CLK10.72248321
98AKT30.71721144
99MOS0.71400771
100CSK0.68817024
101NLK0.67401771
102JAK10.67382582
103HCK0.64603252
104LYN0.63817849
105FGFR40.63563928
106PRKD10.63043730
107IGF1R0.62647467
108MAPK40.61222756
109RIPK10.60945141
110MAP3K130.60830703
111PKN20.60445108
112RPS6KA40.60298786
113AKT20.59802443
114IRAK10.59465310
115PTK2B0.57833265
116CDK70.57471631
117MKNK20.56151453
118BRD40.55857719
119MAPK30.54609955
120FGR0.54173516
121PDK10.53814835
122IKBKE0.53529467
123DYRK30.52875906
124MAPK80.52533443
125MTOR0.52446437
126PIM10.52059688
127ABL10.51780254
128ERBB20.51606091
129CDK30.51278217
130ILK0.50852300
131MATK0.50715156
132STK110.50573613
133RET0.50140063
134CAMK10.50062675
135MAP4K20.49465811
136PKN10.48959160
137ADRBK20.48722406
138PRKCQ0.48645438
139NEK90.47553226
140ROCK10.46500931
141TEC0.45791773
142STK100.44328683
143LRRK20.43662030
144ROCK20.43316374
145SGK30.42910874
146DYRK20.42378473
147MAPK130.39988267
148SGK4940.39767562
149SGK2230.39767562
150EIF2AK20.39623427
151RPS6KA60.39244104
152CAMK40.39194484
153LCK0.39118268
154STK40.38841906
155PAK40.38616181
156INSR0.38308324
157MAPKAPK20.37866790
158EPHA30.37864111
159SRC0.37801984

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.17862358
2Malaria_Homo sapiens_hsa051442.90669820
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.61214394
4ECM-receptor interaction_Homo sapiens_hsa045122.11533593
5Notch signaling pathway_Homo sapiens_hsa043301.97259344
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95802768
7Leishmaniasis_Homo sapiens_hsa051401.90726932
8Lysosome_Homo sapiens_hsa041421.90112715
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81794496
10Basal cell carcinoma_Homo sapiens_hsa052171.80850904
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64953386
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.63886194
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60554458
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.58964868
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56472703
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55591974
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55530235
18Legionellosis_Homo sapiens_hsa051341.55062376
19Asthma_Homo sapiens_hsa053101.54382076
20Focal adhesion_Homo sapiens_hsa045101.52305413
21Measles_Homo sapiens_hsa051621.47422363
22Small cell lung cancer_Homo sapiens_hsa052221.46737715
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.40784403
24Steroid biosynthesis_Homo sapiens_hsa001001.39970118
25Linoleic acid metabolism_Homo sapiens_hsa005911.39789586
26Hedgehog signaling pathway_Homo sapiens_hsa043401.36601098
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35604066
28Osteoclast differentiation_Homo sapiens_hsa043801.33700747
29Acute myeloid leukemia_Homo sapiens_hsa052211.32616462
30Hippo signaling pathway_Homo sapiens_hsa043901.32316201
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31742035
32Rheumatoid arthritis_Homo sapiens_hsa053231.31483394
33Shigellosis_Homo sapiens_hsa051311.30636964
34Protein export_Homo sapiens_hsa030601.30373133
35Choline metabolism in cancer_Homo sapiens_hsa052311.30282404
36Dilated cardiomyopathy_Homo sapiens_hsa054141.28603355
37Proteoglycans in cancer_Homo sapiens_hsa052051.27941565
38TNF signaling pathway_Homo sapiens_hsa046681.27347707
39Autoimmune thyroid disease_Homo sapiens_hsa053201.27329249
40Staphylococcus aureus infection_Homo sapiens_hsa051501.27131408
41VEGF signaling pathway_Homo sapiens_hsa043701.26840110
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26737359
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.26385217
44MicroRNAs in cancer_Homo sapiens_hsa052061.26081023
45Viral myocarditis_Homo sapiens_hsa054161.22628458
46ABC transporters_Homo sapiens_hsa020101.22163169
47Other glycan degradation_Homo sapiens_hsa005111.20660834
48Phagosome_Homo sapiens_hsa041451.20251758
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.16913176
50Pertussis_Homo sapiens_hsa051331.16532415
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.15115328
52Salmonella infection_Homo sapiens_hsa051321.13321377
53Amoebiasis_Homo sapiens_hsa051461.12547879
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12102255
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11869527
56Adherens junction_Homo sapiens_hsa045201.10770367
57p53 signaling pathway_Homo sapiens_hsa041151.09252127
58T cell receptor signaling pathway_Homo sapiens_hsa046601.08191537
59TGF-beta signaling pathway_Homo sapiens_hsa043501.07337743
60Cocaine addiction_Homo sapiens_hsa050301.07265123
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05751030
62Tuberculosis_Homo sapiens_hsa051521.05144549
63Toxoplasmosis_Homo sapiens_hsa051451.02958164
64HTLV-I infection_Homo sapiens_hsa051661.02034075
65One carbon pool by folate_Homo sapiens_hsa006700.97445716
66Herpes simplex infection_Homo sapiens_hsa051680.96912788
67Fatty acid biosynthesis_Homo sapiens_hsa000610.96382857
68Prostate cancer_Homo sapiens_hsa052150.95592512
69Protein digestion and absorption_Homo sapiens_hsa049740.95140356
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.94056960
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93913963
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93776348
73Base excision repair_Homo sapiens_hsa034100.91589241
74Chronic myeloid leukemia_Homo sapiens_hsa052200.91505826
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90606623
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.90227232
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89945168
78Morphine addiction_Homo sapiens_hsa050320.89726484
79N-Glycan biosynthesis_Homo sapiens_hsa005100.89522805
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89399417
81Melanoma_Homo sapiens_hsa052180.88847063
82Ether lipid metabolism_Homo sapiens_hsa005650.88121621
83Apoptosis_Homo sapiens_hsa042100.87326082
84Regulation of autophagy_Homo sapiens_hsa041400.85101213
85Lysine degradation_Homo sapiens_hsa003100.84633810
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84333052
87Histidine metabolism_Homo sapiens_hsa003400.84091760
88Hematopoietic cell lineage_Homo sapiens_hsa046400.83419385
89Hepatitis B_Homo sapiens_hsa051610.83211672
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82732800
91Sphingolipid metabolism_Homo sapiens_hsa006000.82198439
92African trypanosomiasis_Homo sapiens_hsa051430.81892790
93Graft-versus-host disease_Homo sapiens_hsa053320.81586045
94Axon guidance_Homo sapiens_hsa043600.79583786
95Pathways in cancer_Homo sapiens_hsa052000.79462213
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.76653704
97Ovarian steroidogenesis_Homo sapiens_hsa049130.76541806
98Cholinergic synapse_Homo sapiens_hsa047250.76426982
99MAPK signaling pathway_Homo sapiens_hsa040100.76421008
100B cell receptor signaling pathway_Homo sapiens_hsa046620.76075218
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75638436
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.74454823
103Platelet activation_Homo sapiens_hsa046110.74330881
104Inositol phosphate metabolism_Homo sapiens_hsa005620.73715373
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73665984
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73627939
107Influenza A_Homo sapiens_hsa051640.73623583
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72414818
109Arachidonic acid metabolism_Homo sapiens_hsa005900.71962089
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71828505
111Fatty acid degradation_Homo sapiens_hsa000710.70801008
112Phototransduction_Homo sapiens_hsa047440.70621555
113Butanoate metabolism_Homo sapiens_hsa006500.70438938
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.70303256
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.70217186
116Glutamatergic synapse_Homo sapiens_hsa047240.69378265
117mTOR signaling pathway_Homo sapiens_hsa041500.68685924
118Peroxisome_Homo sapiens_hsa041460.66737326
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.65900551
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65543496
121Arginine and proline metabolism_Homo sapiens_hsa003300.64701906
122Cell cycle_Homo sapiens_hsa041100.63709402
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63409201
124Type I diabetes mellitus_Homo sapiens_hsa049400.61457552
125Hepatitis C_Homo sapiens_hsa051600.61293237
126Rap1 signaling pathway_Homo sapiens_hsa040150.60223863
127Glycerolipid metabolism_Homo sapiens_hsa005610.59611427
128Circadian entrainment_Homo sapiens_hsa047130.59379793
129Wnt signaling pathway_Homo sapiens_hsa043100.59145876
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59046076
131GABAergic synapse_Homo sapiens_hsa047270.59010812
132Chemical carcinogenesis_Homo sapiens_hsa052040.58669080
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58613942
134Ras signaling pathway_Homo sapiens_hsa040140.58351620
135Prolactin signaling pathway_Homo sapiens_hsa049170.58132570
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57743798
137Oxytocin signaling pathway_Homo sapiens_hsa049210.56964499
138Endocytosis_Homo sapiens_hsa041440.56443216
139GnRH signaling pathway_Homo sapiens_hsa049120.56239594
140Complement and coagulation cascades_Homo sapiens_hsa046100.55502212
141Antigen processing and presentation_Homo sapiens_hsa046120.54965187
142Allograft rejection_Homo sapiens_hsa053300.54876604
143Insulin resistance_Homo sapiens_hsa049310.54817384
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54408787
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53583666
146Caffeine metabolism_Homo sapiens_hsa002320.53429501
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.52023773
148Bile secretion_Homo sapiens_hsa049760.51593737
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51097932
150cAMP signaling pathway_Homo sapiens_hsa040240.49647085
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48588075
152Vitamin digestion and absorption_Homo sapiens_hsa049770.48365040
153PPAR signaling pathway_Homo sapiens_hsa033200.48285542
154Non-small cell lung cancer_Homo sapiens_hsa052230.47302033
155Primary immunodeficiency_Homo sapiens_hsa053400.46603334
156Bladder cancer_Homo sapiens_hsa052190.46279992
157Chemokine signaling pathway_Homo sapiens_hsa040620.45655531
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45493034
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44259179
160Melanogenesis_Homo sapiens_hsa049160.43761194
161Pancreatic cancer_Homo sapiens_hsa052120.42945180

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