TMEM199

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) in some human cells. The encoded protein shares some homology with the yeast protein Vma12. Defects in this gene are a cause of congenital disorder of glycosylation, type IIp. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.02510910
2ATP synthesis coupled proton transport (GO:0015986)5.59262231
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.59262231
4cullin deneddylation (GO:0010388)5.54771717
5DNA deamination (GO:0045006)5.41321335
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.36796041
7protein deneddylation (GO:0000338)5.14871825
8protein neddylation (GO:0045116)4.86830386
9chaperone-mediated protein transport (GO:0072321)4.86044657
10protein complex biogenesis (GO:0070271)4.60575703
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.60523767
12NADH dehydrogenase complex assembly (GO:0010257)4.60523767
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.60523767
14respiratory electron transport chain (GO:0022904)4.57124721
15electron transport chain (GO:0022900)4.48146695
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.35289696
17mitochondrial respiratory chain complex assembly (GO:0033108)4.19807815
18rRNA modification (GO:0000154)4.08930806
19neuron cell-cell adhesion (GO:0007158)4.08853954
20ATP hydrolysis coupled proton transport (GO:0015991)3.98575094
21energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.98575094
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.95120758
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.95120758
24preassembly of GPI anchor in ER membrane (GO:0016254)3.92054125
25L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.71778716
26proteasome assembly (GO:0043248)3.70540772
27transferrin transport (GO:0033572)3.64468867
28pseudouridine synthesis (GO:0001522)3.64288759
29presynaptic membrane assembly (GO:0097105)3.59292075
30rRNA methylation (GO:0031167)3.59167612
31DNA double-strand break processing (GO:0000729)3.57187038
32regulation of cellular amino acid metabolic process (GO:0006521)3.53982619
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51388672
347-methylguanosine mRNA capping (GO:0006370)3.50979958
35iron-sulfur cluster assembly (GO:0016226)3.48886655
36metallo-sulfur cluster assembly (GO:0031163)3.48886655
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.47444871
38termination of RNA polymerase III transcription (GO:0006386)3.47444871
39regulation of mitochondrial translation (GO:0070129)3.46790147
40piRNA metabolic process (GO:0034587)3.45871725
41RNA capping (GO:0036260)3.45647658
427-methylguanosine RNA capping (GO:0009452)3.45647658
43respiratory chain complex IV assembly (GO:0008535)3.42860624
44platelet dense granule organization (GO:0060155)3.41257372
45establishment of protein localization to mitochondrion (GO:0072655)3.40918698
46presynaptic membrane organization (GO:0097090)3.36114749
47protein targeting to mitochondrion (GO:0006626)3.34994189
48ferric iron transport (GO:0015682)3.34125216
49trivalent inorganic cation transport (GO:0072512)3.34125216
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33672485
51signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29596585
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29596585
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28386696
54synaptic vesicle exocytosis (GO:0016079)3.27425736
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26971144
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26971144
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26971144
58positive regulation of mitochondrial fission (GO:0090141)3.24588003
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22727670
60negative regulation of ligase activity (GO:0051352)3.22727670
61methionine biosynthetic process (GO:0009086)3.22454554
62DNA catabolic process, exonucleolytic (GO:0000738)3.22032565
63hydrogen ion transmembrane transport (GO:1902600)3.21722350
64dopamine transport (GO:0015872)3.20580259
65indole-containing compound catabolic process (GO:0042436)3.18529354
66indolalkylamine catabolic process (GO:0046218)3.18529354
67tryptophan catabolic process (GO:0006569)3.18529354
68C-terminal protein lipidation (GO:0006501)3.17332516
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15272477
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.15272477
71protein localization to mitochondrion (GO:0070585)3.12712507
72inner mitochondrial membrane organization (GO:0007007)3.12703674
73cytochrome complex assembly (GO:0017004)3.12419210
74ubiquinone biosynthetic process (GO:0006744)3.11600976
75signal transduction involved in cell cycle checkpoint (GO:0072395)3.11370040
76mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.10514674
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09599314
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08728032
79protein-cofactor linkage (GO:0018065)3.05408464
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03725761
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03560692
82mitochondrial RNA metabolic process (GO:0000959)3.02864169
83tryptophan metabolic process (GO:0006568)3.02586384
84mitochondrion morphogenesis (GO:0070584)3.01701253
85establishment of integrated proviral latency (GO:0075713)3.00639801
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99764749
87peptidyl-histidine modification (GO:0018202)2.98599680
88long-chain fatty acid biosynthetic process (GO:0042759)2.96844211
89fucose catabolic process (GO:0019317)2.96496163
90L-fucose metabolic process (GO:0042354)2.96496163
91L-fucose catabolic process (GO:0042355)2.96496163
92kynurenine metabolic process (GO:0070189)2.96303231
93protein localization to cilium (GO:0061512)2.94455754
94proton transport (GO:0015992)2.94115262
95postsynaptic membrane organization (GO:0001941)2.92962642
96regulation of cellular amine metabolic process (GO:0033238)2.90903047
97ubiquinone metabolic process (GO:0006743)2.90310687
98C-terminal protein amino acid modification (GO:0018410)2.90216555
99RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89811076
100ATP biosynthetic process (GO:0006754)2.88938900
101purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88508828
102establishment of viral latency (GO:0019043)2.88149251
103GTP biosynthetic process (GO:0006183)2.87003577
104oxidative phosphorylation (GO:0006119)2.86932830
105protein localization to synapse (GO:0035418)2.86422497
106guanosine-containing compound biosynthetic process (GO:1901070)2.86120581
107hydrogen transport (GO:0006818)2.86084789
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85693877
109purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83654611
110methionine metabolic process (GO:0006555)2.81782850
111tRNA processing (GO:0008033)2.81311776
112dopamine biosynthetic process (GO:0042416)2.80781116
113L-methionine salvage (GO:0071267)2.79109081
114L-methionine biosynthetic process (GO:0071265)2.79109081
115amino acid salvage (GO:0043102)2.79109081
116pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76798597
117neuronal action potential propagation (GO:0019227)2.76284042
118positive regulation of ligase activity (GO:0051351)2.74195360
119antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.73771323
120mannosylation (GO:0097502)2.73543310
121neurotransmitter uptake (GO:0001504)2.72399261
122indolalkylamine metabolic process (GO:0006586)2.71392939
123transcription elongation from RNA polymerase I promoter (GO:0006362)2.69951534
124substantia nigra development (GO:0021762)2.68671557
125pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66815641
126viral protein processing (GO:0019082)2.66810199
127phagosome maturation (GO:0090382)2.66171630
128positive regulation of defense response to virus by host (GO:0002230)2.65888030
129regulation of catecholamine metabolic process (GO:0042069)2.64562049
130regulation of dopamine metabolic process (GO:0042053)2.64562049
131positive regulation of protein homodimerization activity (GO:0090073)2.64252538
132base-excision repair, AP site formation (GO:0006285)2.61499613
133deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.60297767
134intracellular protein transmembrane import (GO:0044743)2.59894118
135regulation of cilium movement (GO:0003352)2.59628404
136positive regulation of synapse assembly (GO:0051965)2.59206592
137regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59113629
138DNA methylation involved in gamete generation (GO:0043046)2.57607922
139maturation of 5.8S rRNA (GO:0000460)2.55915008
140negative regulation of neurotransmitter transport (GO:0051589)2.55391586
141ribonucleoside triphosphate biosynthetic process (GO:0009201)2.54293489
142positive regulation of prostaglandin secretion (GO:0032308)2.53453487
143dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.53262809
144tRNA metabolic process (GO:0006399)2.52279885
145regulation of synaptic vesicle exocytosis (GO:2000300)2.51607189
146aspartate family amino acid biosynthetic process (GO:0009067)2.50743635
147DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.50731387
148somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48655146
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48655146
150isotype switching (GO:0045190)2.48655146
151DNA damage response, detection of DNA damage (GO:0042769)2.45717462
152negative regulation of telomere maintenance (GO:0032205)2.45270109
153amine catabolic process (GO:0009310)2.44066886
154cellular biogenic amine catabolic process (GO:0042402)2.44066886
155positive regulation of T-helper 1 type immune response (GO:0002827)2.43345222
156cytidine catabolic process (GO:0006216)2.43325583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.45535798
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.81344065
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.61578092
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53829875
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.52830798
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03522545
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.97369864
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94488906
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.91750977
10PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.86472015
11GBX2_23144817_ChIP-Seq_PC3_Human2.81881023
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71390028
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70133491
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.67595286
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56739386
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.50749364
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.46644193
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45759564
19EZH2_22144423_ChIP-Seq_EOC_Human2.40134701
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.19476520
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.18258753
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.12944649
23TAF15_26573619_Chip-Seq_HEK293_Human2.06610182
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.06173959
25VDR_22108803_ChIP-Seq_LS180_Human2.00464530
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95872301
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95208319
28VDR_23849224_ChIP-Seq_CD4+_Human1.91142352
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.87404029
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85217623
31FUS_26573619_Chip-Seq_HEK293_Human1.81246527
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78972655
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78776355
34* DCP1A_22483619_ChIP-Seq_HELA_Human1.73923110
35ELK1_19687146_ChIP-ChIP_HELA_Human1.71399727
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69872961
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67650643
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66642410
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65292154
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61405703
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60515185
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59807179
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56078842
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55669268
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53374562
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50039175
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48531844
48FOXP3_21729870_ChIP-Seq_TREG_Human1.47553634
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47346528
50GABP_19822575_ChIP-Seq_HepG2_Human1.46823594
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45824152
52CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.45411205
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44981432
54REST_21632747_ChIP-Seq_MESCs_Mouse1.41486484
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38641441
56KDM5A_27292631_Chip-Seq_BREAST_Human1.37931115
57IRF1_19129219_ChIP-ChIP_H3396_Human1.37878264
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35702724
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35535665
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34388240
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34163254
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32555467
63CIITA_25753668_ChIP-Seq_RAJI_Human1.29926140
64TP53_22573176_ChIP-Seq_HFKS_Human1.28538127
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28035035
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.26331821
67GATA3_26560356_Chip-Seq_TH2_Human1.25808941
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24973492
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23717850
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23136088
71XRN2_22483619_ChIP-Seq_HELA_Human1.22858855
72ER_23166858_ChIP-Seq_MCF-7_Human1.21882185
73RNF2_27304074_Chip-Seq_NSC_Mouse1.21840706
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.20436390
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20155197
76TTF2_22483619_ChIP-Seq_HELA_Human1.20103938
77EWS_26573619_Chip-Seq_HEK293_Human1.20100674
78TFEB_21752829_ChIP-Seq_HELA_Human1.19374631
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18593953
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18550583
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17701824
82P300_19829295_ChIP-Seq_ESCs_Human1.17144587
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15209665
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.14904023
85* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13893070
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13078134
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12169179
88REST_19997604_ChIP-ChIP_NEURONS_Mouse1.11349094
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10985284
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10875913
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10081904
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09948270
93CBP_20019798_ChIP-Seq_JUKART_Human1.05967143
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05967143
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05911538
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05911429
97SPI1_23547873_ChIP-Seq_NB4_Human1.05570848
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05275663
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05012035
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04699194
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03113026
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02753399
103IGF1R_20145208_ChIP-Seq_DFB_Human1.02442961
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01809528
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01052350
106JUN_21703547_ChIP-Seq_K562_Human1.00348775
107* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98537134
108EZH2_27304074_Chip-Seq_ESCs_Mouse0.98156563
109NCOR_22424771_ChIP-Seq_293T_Human0.98081573
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98025015
111AR_20517297_ChIP-Seq_VCAP_Human0.96876406
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96560575
113FOXA1_25329375_ChIP-Seq_VCAP_Human0.96560575
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96520355
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94929843
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94307707
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93374931
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93353440
119MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93244061
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91476995
121MYB_26560356_Chip-Seq_TH2_Human0.91168070
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.90654316
123NANOG_19829295_ChIP-Seq_ESCs_Human0.88697139
124SOX2_19829295_ChIP-Seq_ESCs_Human0.88697139
125GATA3_21878914_ChIP-Seq_MCF-7_Human0.88695890
126JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86813999
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86394779
128CBX2_27304074_Chip-Seq_ESCs_Mouse0.86252797
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84972281
130MYC_18940864_ChIP-ChIP_HL60_Human0.84921790
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84437036
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84325072
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.84220905
134ELF5_23300383_ChIP-Seq_T47D_Human0.84023503
135SOX2_16153702_ChIP-ChIP_HESCs_Human0.83257537
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83226064
137GATA3_26560356_Chip-Seq_TH1_Human0.83207871
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82724325
139SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81089824
140ZNF274_21170338_ChIP-Seq_K562_Hela0.80757497
141SOX9_26525672_Chip-Seq_HEART_Mouse0.79819933
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79365821
143SOX17_20123909_ChIP-Seq_XEN_Mouse0.77100365
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.77082486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.03588277
2MP0003806_abnormal_nucleotide_metabolis4.08078598
3MP0001529_abnormal_vocalization3.70697542
4MP0001905_abnormal_dopamine_level2.99784943
5MP0006276_abnormal_autonomic_nervous2.86317691
6MP0004270_analgesia2.52476729
7MP0005671_abnormal_response_to2.47642389
8MP0002736_abnormal_nociception_after2.47558291
9MP0001968_abnormal_touch/_nociception2.46256487
10MP0002064_seizures2.43831853
11MP0004859_abnormal_synaptic_plasticity2.40402861
12MP0003195_calcinosis2.40341064
13MP0009745_abnormal_behavioral_response2.39309120
14MP0005646_abnormal_pituitary_gland2.35562729
15MP0003635_abnormal_synaptic_transmissio2.34791616
16MP0009046_muscle_twitch2.30587283
17MP0001835_abnormal_antigen_presentation2.20040051
18MP0002138_abnormal_hepatobiliary_system2.19293233
19MP0003122_maternal_imprinting2.18522037
20MP0002272_abnormal_nervous_system2.18380388
21MP0002734_abnormal_mechanical_nocicepti2.17341695
22MP0005075_abnormal_melanosome_morpholog2.17144539
23MP0002822_catalepsy2.12869807
24MP0009785_altered_susceptibility_to2.12619779
25MP0002572_abnormal_emotion/affect_behav2.08437167
26MP0001986_abnormal_taste_sensitivity2.04830768
27MP0002063_abnormal_learning/memory/cond2.02552218
28MP0002735_abnormal_chemical_nociception2.01458333
29MP0001440_abnormal_grooming_behavior2.01111760
30MP0002148_abnormal_hypersensitivity_rea2.00831443
31MP0004142_abnormal_muscle_tone1.91550483
32MP0002638_abnormal_pupillary_reflex1.90463476
33MP0008877_abnormal_DNA_methylation1.88751858
34MP0008789_abnormal_olfactory_epithelium1.83859374
35MP0005171_absent_coat_pigmentation1.83071542
36MP0002163_abnormal_gland_morphology1.79115637
37MP0002876_abnormal_thyroid_physiology1.75079616
38MP0001984_abnormal_olfaction1.73615443
39MP0003786_premature_aging1.71400779
40MP0005386_behavior/neurological_phenoty1.67350376
41MP0004924_abnormal_behavior1.67350376
42MP0001486_abnormal_startle_reflex1.67068449
43MP0002067_abnormal_sensory_capabilities1.65578510
44MP0005084_abnormal_gallbladder_morpholo1.64536155
45MP0005379_endocrine/exocrine_gland_phen1.64389511
46MP0003186_abnormal_redox_activity1.63845573
47MP0002733_abnormal_thermal_nociception1.63512291
48MP0010386_abnormal_urinary_bladder1.63496320
49MP0001970_abnormal_pain_threshold1.62299005
50MP0003787_abnormal_imprinting1.62211096
51MP0001188_hyperpigmentation1.61387704
52MP0005423_abnormal_somatic_nervous1.59162673
53MP0001501_abnormal_sleep_pattern1.56524656
54MP0003329_amyloid_beta_deposits1.55523816
55MP0005645_abnormal_hypothalamus_physiol1.55241631
56MP0003718_maternal_effect1.51455262
57MP0001800_abnormal_humoral_immune1.50948868
58MP0009840_abnormal_foam_cell1.50043978
59MP0005499_abnormal_olfactory_system1.49370603
60MP0006082_CNS_inflammation1.49221746
61MP0003724_increased_susceptibility_to1.45916809
62MP0003123_paternal_imprinting1.45544459
63MP0000372_irregular_coat_pigmentation1.42333178
64MP0003121_genomic_imprinting1.42240398
65MP0002837_dystrophic_cardiac_calcinosis1.42091065
66MP0005000_abnormal_immune_tolerance1.41149982
67MP0006072_abnormal_retinal_apoptosis1.40235001
68MP0006035_abnormal_mitochondrial_morpho1.39802710
69MP0006292_abnormal_olfactory_placode1.39267173
70MP0005310_abnormal_salivary_gland1.38962790
71MP0008995_early_reproductive_senescence1.38226364
72MP0000685_abnormal_immune_system1.36604468
73MP0002184_abnormal_innervation1.33991661
74MP0010094_abnormal_chromosome_stability1.33162707
75MP0001790_abnormal_immune_system1.33152374
76MP0005387_immune_system_phenotype1.33152374
77MP0000778_abnormal_nervous_system1.31153870
78MP0002723_abnormal_immune_serum1.30804443
79MP0002452_abnormal_antigen_presenting1.30570360
80MP0006036_abnormal_mitochondrial_physio1.29878101
81MP0003136_yellow_coat_color1.29724071
82MP0009333_abnormal_splenocyte_physiolog1.29477331
83MP0009764_decreased_sensitivity_to1.26811240
84MP0001485_abnormal_pinna_reflex1.24650805
85MP0002751_abnormal_autonomic_nervous1.22382844
86MP0003646_muscle_fatigue1.21891008
87MP0002557_abnormal_social/conspecific_i1.20167211
88MP0002277_abnormal_respiratory_mucosa1.19745119
89MP0002420_abnormal_adaptive_immunity1.18288888
90MP0004742_abnormal_vestibular_system1.16815230
91MP0001819_abnormal_immune_cell1.15594624
92MP0003879_abnormal_hair_cell1.12420804
93MP0005025_abnormal_response_to1.10345881
94MP0002066_abnormal_motor_capabilities/c1.09614339
95MP0001963_abnormal_hearing_physiology1.07859130
96MP0008260_abnormal_autophagy1.07359643
97MP0002882_abnormal_neuron_morphology1.06660124
98MP0000631_abnormal_neuroendocrine_gland1.06189786
99MP0002229_neurodegeneration1.04897874
100MP0002419_abnormal_innate_immunity1.02243036
101MP0005551_abnormal_eye_electrophysiolog1.02230533
102MP0000015_abnormal_ear_pigmentation0.99858603
103MP0008932_abnormal_embryonic_tissue0.98986781
104MP0000955_abnormal_spinal_cord0.97643223
105MP0001919_abnormal_reproductive_system0.97581033
106MP0008875_abnormal_xenobiotic_pharmacok0.97494762
107MP0004147_increased_porphyrin_level0.96538842
108MP0005409_darkened_coat_color0.95051912
109MP0003011_delayed_dark_adaptation0.94512108
110MP0001845_abnormal_inflammatory_respons0.94041040
111MP0005058_abnormal_lysosome_morphology0.93653369
112MP0008057_abnormal_DNA_replication0.93289616
113MP0000569_abnormal_digit_pigmentation0.92098770
114MP0001929_abnormal_gametogenesis0.91823936
115MP0000689_abnormal_spleen_morphology0.91169930
116MP0005408_hypopigmentation0.89940610
117MP0005253_abnormal_eye_physiology0.89044860
118MP0004133_heterotaxia0.88915585
119MP0008469_abnormal_protein_level0.88771766
120MP0005389_reproductive_system_phenotype0.87415001
121MP0000716_abnormal_immune_system0.86861643
122MP0000026_abnormal_inner_ear0.86757079
123MP0004811_abnormal_neuron_physiology0.86256993
124MP0004957_abnormal_blastocyst_morpholog0.86073919
125MP0001502_abnormal_circadian_rhythm0.84784074
126MP0001324_abnormal_eye_pigmentation0.84686584
127MP0002693_abnormal_pancreas_physiology0.84590514
128MP0002102_abnormal_ear_morphology0.83936203
129MP0002095_abnormal_skin_pigmentation0.83863196
130MP0002752_abnormal_somatic_nervous0.83689188
131MP0008058_abnormal_DNA_repair0.83591946
132MP0003693_abnormal_embryo_hatching0.83150390
133MP0005266_abnormal_metabolism0.81226517
134MP0005332_abnormal_amino_acid0.80382104
135MP0002160_abnormal_reproductive_system0.77727892
136MP0005083_abnormal_biliary_tract0.77206384
137MP0008872_abnormal_physiological_respon0.77153265
138MP0005451_abnormal_body_composition0.77152219
139MP0002210_abnormal_sex_determination0.77081096
140MP0002152_abnormal_brain_morphology0.76279774
141MP0001664_abnormal_digestion0.75776804
142MP0003763_abnormal_thymus_physiology0.75757469
143MP0003172_abnormal_lysosome_physiology0.75449395
144MP0003634_abnormal_glial_cell0.75090073
145MP0002653_abnormal_ependyma_morphology0.74672071
146MP0000371_diluted_coat_color0.74452730
147MP0002398_abnormal_bone_marrow0.74432037
148MP0000920_abnormal_myelination0.72280302
149MP0003632_abnormal_nervous_system0.72144084
150MP0002405_respiratory_system_inflammati0.72057125
151MP0005647_abnormal_sex_gland0.70980401
152MP0002722_abnormal_immune_system0.70485217
153MP0000358_abnormal_cell_content/0.70287681
154MP0000427_abnormal_hair_cycle0.69725365
155MP0003111_abnormal_nucleus_morphology0.69526237
156MP0009697_abnormal_copulation0.69124704
157MP0009379_abnormal_foot_pigmentation0.69066983
158MP0001764_abnormal_homeostasis0.66974721
159MP0004145_abnormal_muscle_electrophysio0.66259845
160MP0003183_abnormal_peptide_metabolism0.65695087
161MP0004885_abnormal_endolymph0.64877204
162MP0005410_abnormal_fertilization0.63951555
163MP0003137_abnormal_impulse_conducting0.63485225
164MP0005394_taste/olfaction_phenotype0.63045854

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.90259272
2Abnormal mitochondria in muscle tissue (HP:0008316)5.36202329
3Mitochondrial inheritance (HP:0001427)4.98952320
4Progressive macrocephaly (HP:0004481)4.83435362
5Hepatocellular necrosis (HP:0001404)4.57175776
6Acute encephalopathy (HP:0006846)4.49072126
7Increased CSF lactate (HP:0002490)4.41011679
8Abnormality of glycolysis (HP:0004366)4.26716325
9Increased serum pyruvate (HP:0003542)4.26716325
10Focal motor seizures (HP:0011153)4.00059779
11Hepatic necrosis (HP:0002605)3.63219571
12Cerebral hypomyelination (HP:0006808)3.60647031
13Pheochromocytoma (HP:0002666)3.39118261
14Hypothermia (HP:0002045)3.34122973
15Abnormal hair whorl (HP:0010721)3.31898018
16Neuroendocrine neoplasm (HP:0100634)3.31601287
17Atonic seizures (HP:0010819)3.25728307
18Leukodystrophy (HP:0002415)3.13649764
19Optic disc pallor (HP:0000543)3.07251614
20Medial flaring of the eyebrow (HP:0010747)3.03897462
21Increased hepatocellular lipid droplets (HP:0006565)3.03704264
22Molar tooth sign on MRI (HP:0002419)3.02594648
23Abnormality of midbrain morphology (HP:0002418)3.02594648
243-Methylglutaconic aciduria (HP:0003535)3.02050259
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.98509244
26Abnormal protein N-linked glycosylation (HP:0012347)2.98509244
27Abnormal protein glycosylation (HP:0012346)2.98509244
28Abnormal glycosylation (HP:0012345)2.98509244
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.97459046
30Gait imbalance (HP:0002141)2.97324690
31Exercise intolerance (HP:0003546)2.92315836
32Respiratory failure (HP:0002878)2.90780420
33Congenital primary aphakia (HP:0007707)2.88682893
34Increased serum lactate (HP:0002151)2.87449900
35Lactic acidosis (HP:0003128)2.82150293
36Congenital stationary night blindness (HP:0007642)2.78443634
37Nephrogenic diabetes insipidus (HP:0009806)2.77515996
38Renal Fanconi syndrome (HP:0001994)2.77398048
39Abnormal rod and cone electroretinograms (HP:0008323)2.76524389
40Cerebral edema (HP:0002181)2.74463611
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71636185
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69301265
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69301265
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66210016
45Reduced antithrombin III activity (HP:0001976)2.64836172
46Panhypogammaglobulinemia (HP:0003139)2.63077615
47Epileptic encephalopathy (HP:0200134)2.62980261
48Lipid accumulation in hepatocytes (HP:0006561)2.59948116
49Severe combined immunodeficiency (HP:0004430)2.57800054
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54831110
51Abnormality of alanine metabolism (HP:0010916)2.54831110
52Hyperalaninemia (HP:0003348)2.54831110
53Emotional lability (HP:0000712)2.53544347
54Thyroiditis (HP:0100646)2.49330424
55Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46328358
56Retrobulbar optic neuritis (HP:0100654)2.45757238
57Optic neuritis (HP:0100653)2.45757238
58CNS hypomyelination (HP:0003429)2.45529045
59CNS demyelination (HP:0007305)2.44565446
60Absence seizures (HP:0002121)2.44099830
61Myokymia (HP:0002411)2.43811687
62Poor suck (HP:0002033)2.42132389
63Attenuation of retinal blood vessels (HP:0007843)2.42116188
64Dialeptic seizures (HP:0011146)2.40734563
65IgG deficiency (HP:0004315)2.40116026
66Delusions (HP:0000746)2.39869014
67Limb dystonia (HP:0002451)2.35731615
68Abnormality of B cell number (HP:0010975)2.35489888
69Visual hallucinations (HP:0002367)2.35165295
70Vaginal atresia (HP:0000148)2.35128186
71Hypoproteinemia (HP:0003075)2.34587759
72B lymphocytopenia (HP:0010976)2.33421865
73Genital tract atresia (HP:0001827)2.30771444
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.24639216
75Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24639216
76Abnormality of the labia minora (HP:0012880)2.23143413
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22762688
78Focal seizures (HP:0007359)2.19796114
79X-linked dominant inheritance (HP:0001423)2.18757835
80Poor coordination (HP:0002370)2.18637972
81Hyperventilation (HP:0002883)2.18410350
82Febrile seizures (HP:0002373)2.17221097
83Inability to walk (HP:0002540)2.17126670
84Progressive microcephaly (HP:0000253)2.16813148
85Combined immunodeficiency (HP:0005387)2.14112320
86Parakeratosis (HP:0001036)2.12680195
87Microvesicular hepatic steatosis (HP:0001414)2.10892356
88Autoamputation (HP:0001218)2.08762895
89Abolished electroretinogram (ERG) (HP:0000550)2.08448830
90Abnormality of eosinophils (HP:0001879)2.07995681
91Stomatitis (HP:0010280)2.07266459
92Lethargy (HP:0001254)2.04392476
93Nephronophthisis (HP:0000090)2.04351278
94Aplastic anemia (HP:0001915)2.03265225
95Unsteady gait (HP:0002317)2.03115243
96Increased intramyocellular lipid droplets (HP:0012240)2.02782463
97Eosinophilia (HP:0001880)2.01559743
98Constricted visual fields (HP:0001133)2.01026626
99Abnormal pupillary function (HP:0007686)2.01008555
100Abnormality of lateral ventricle (HP:0030047)1.98734206
101Methylmalonic aciduria (HP:0012120)1.98343159
102Vacuolated lymphocytes (HP:0001922)1.97371529
103Type I transferrin isoform profile (HP:0003642)1.94612685
104Microretrognathia (HP:0000308)1.94591936
105Pancreatic fibrosis (HP:0100732)1.94495120
106Polyphagia (HP:0002591)1.92760115
107Postnatal microcephaly (HP:0005484)1.92713205
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.91771860
109Orchitis (HP:0100796)1.89603502
110Encephalitis (HP:0002383)1.87517958
111Progressive cerebellar ataxia (HP:0002073)1.87066918
112Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86115607
113Hypoplastic left heart (HP:0004383)1.85787474
114Type 2 muscle fiber atrophy (HP:0003554)1.84850404
115Myositis (HP:0100614)1.84744678
116Elevated erythrocyte sedimentation rate (HP:0003565)1.84073462
117Fair hair (HP:0002286)1.83813765
118Opisthotonus (HP:0002179)1.83765392
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.81662528
120Esotropia (HP:0000565)1.81553988
121Generalized tonic-clonic seizures (HP:0002069)1.81396994
122Renal cortical cysts (HP:0000803)1.80579573
123Abnormal autonomic nervous system physiology (HP:0012332)1.78582569
124Methylmalonic acidemia (HP:0002912)1.78561745
125Respiratory difficulties (HP:0002880)1.75728011
126Hypoplastic pelvis (HP:0008839)1.74704480
127Hypokinesia (HP:0002375)1.74476459
128Exertional dyspnea (HP:0002875)1.74135226
129Failure to thrive in infancy (HP:0001531)1.73766668
130Aplasia/hypoplasia of the uterus (HP:0008684)1.72997668
131Stomach cancer (HP:0012126)1.72876502
132Abnormality of renal resorption (HP:0011038)1.72312713
133Prostate neoplasm (HP:0100787)1.71209027
134Short tibia (HP:0005736)1.69912717
135Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69882957
136Type II lissencephaly (HP:0007260)1.68801560
137Congenital ichthyosiform erythroderma (HP:0007431)1.68658817
138True hermaphroditism (HP:0010459)1.67804996
139Large for gestational age (HP:0001520)1.67362700
140Dry hair (HP:0011359)1.65912467
141Gaze-evoked nystagmus (HP:0000640)1.65547949
142Sensory axonal neuropathy (HP:0003390)1.65355606
143Birth length less than 3rd percentile (HP:0003561)1.64060060
144Keratoconjunctivitis (HP:0001096)1.63860820
145Abnormality of the corticospinal tract (HP:0002492)1.63459210
146Abnormality of serum amino acid levels (HP:0003112)1.63340552
147Hypomagnesemia (HP:0002917)1.63278513
148Hypoplastic heart (HP:0001961)1.62346071
149Aplasia/Hypoplasia of the lens (HP:0008063)1.62112601
150Hypoplasia of the fovea (HP:0007750)1.61433585
151Aplasia/Hypoplasia of the fovea (HP:0008060)1.61433585
152Adrenal hypoplasia (HP:0000835)1.60977560
153Abnormality of the renal cortex (HP:0011035)1.60042796
154Recurrent fungal infections (HP:0002841)1.59554883
155Abnormality of the pons (HP:0007361)1.59271364
156Pancytopenia (HP:0001876)1.58919304
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.58477260
158Dicarboxylic aciduria (HP:0003215)1.58477260
159Abnormality of T cell number (HP:0011839)1.58181567
160Poor speech (HP:0002465)1.57772970
161Absent epiphyses (HP:0010577)1.57106249
162Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57106249
163Pancreatic cysts (HP:0001737)1.56658628
164Delayed gross motor development (HP:0002194)1.56389122
165Specific learning disability (HP:0001328)1.56075976
166Progressive inability to walk (HP:0002505)1.55878091
167Epileptiform EEG discharges (HP:0011182)1.55213220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.18101960
2FRK3.66716762
3TRIM283.37420879
4MAP3K123.36701283
5PINK13.22403435
6STK162.84907007
7MAP2K72.72258001
8NME22.71610566
9NME12.54156867
10ARAF2.51083225
11EIF2AK12.42595568
12BUB12.34049092
13TXK2.25756322
14PNCK2.22621613
15TSSK62.13970254
16TAOK32.01824289
17TLK11.97953615
18BCR1.97602288
19BCKDK1.96840994
20EIF2AK31.95389587
21PLK21.93358041
22MAP3K41.90684953
23NTRK31.81397640
24BMPR1B1.80976173
25VRK21.80199039
26MARK31.79301844
27LIMK11.74139157
28AKT31.73637542
29OXSR11.69644781
30CDK191.63202785
31BRAF1.60365449
32NUAK11.45512895
33MAP4K21.45156758
34GRK51.43015186
35EPHA41.41626212
36SRPK11.39019596
37TNIK1.37855464
38VRK11.34221313
39CCNB11.33722406
40GRK11.33307826
41MAPK131.32411412
42STK391.30294398
43GRK71.28028392
44ADRBK21.27592222
45BMPR21.23435702
46WEE11.20569193
47PBK1.18500537
48DAPK11.16288692
49MAPKAPK51.14962758
50MST41.12458909
51PRPF4B1.11851204
52CAMK2B1.09205007
53SIK31.08006780
54MINK11.07629476
55IKBKB1.06187182
56MARK11.02357904
57MYLK1.00810664
58PLK30.99949391
59PRKCG0.99506731
60CSNK1G30.97791165
61DYRK20.92202046
62CDK80.88771130
63DYRK30.86816452
64ACVR1B0.86093467
65CAMK2A0.85839599
66MAP3K90.82828460
67KIT0.82502289
68NEK60.81013199
69CLK10.80810015
70MAP2K40.80765516
71MATK0.80120622
72RPS6KA50.80049169
73TGFBR10.79762195
74MKNK10.78487733
75PRKCQ0.76994115
76ERBB30.76367172
77PDK30.76325330
78PDK40.76325330
79CDK180.73753049
80WNK30.72763802
81PLK10.72303342
82AURKA0.71895617
83CDK140.71226020
84UHMK10.70448861
85ZAK0.70406067
86MKNK20.69937992
87CSNK1G20.69447763
88FES0.69150958
89CDC70.68622374
90NTRK20.66956043
91SYK0.66738650
92NTRK10.66377717
93PRKCE0.66245738
94WNK40.65580063
95CDK150.65083723
96TESK20.64701660
97PDK20.64501914
98MUSK0.64399173
99CAMK2D0.63155212
100LYN0.62562433
101STK38L0.62099936
102ADRBK10.60475134
103CDK50.60457070
104MAP4K10.60363481
105BRSK10.59611697
106BRSK20.58464729
107CDK11A0.57692667
108CSF1R0.56465554
109ABL20.56239228
110CAMK2G0.55069212
111TESK10.54236240
112SGK2230.53806955
113SGK4940.53806955
114DYRK1A0.53059407
115TNK20.51425124
116MAPKAPK30.50611033
117YES10.50414394
118MAP3K50.49955636
119KDR0.49425540
120OBSCN0.48683508
121BLK0.47960557
122FGR0.47462504
123NEK10.46994540
124PIM20.46991019
125CSNK1G10.46613187
126DAPK30.46157589
127IRAK30.45673550
128PLK40.44679171
129PIK3CA0.43403156
130MAP3K140.42802547
131CSNK2A10.42410022
132MOS0.42325968
133LCK0.41345610
134DAPK20.41210333
135IKBKE0.40921241
136CSNK2A20.40894099
137ATR0.40515794
138SCYL20.40349927
139PKN10.40006762
140TEC0.39487996
141RPS6KA40.39072408
142INSRR0.39008942
143ITK0.37620943
144CSNK1A10.37196180
145CSNK1A1L0.37067696
146RAF10.36996991
147ROCK20.35945348
148CHUK0.34119840
149PRKCI0.32527239
150ATM0.31272230
151MAP2K60.31182240
152IGF1R0.30670686
153CAMKK20.30044575
154ABL10.29393623
155PTK2B0.29152687
156EIF2AK20.28345651
157PIM10.26863010

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.95519457
2Proteasome_Homo sapiens_hsa030504.28228827
3Parkinsons disease_Homo sapiens_hsa050123.97633449
4Collecting duct acid secretion_Homo sapiens_hsa049663.14173230
5Alzheimers disease_Homo sapiens_hsa050103.04877573
6Protein export_Homo sapiens_hsa030602.97239655
7Huntingtons disease_Homo sapiens_hsa050162.85206845
8RNA polymerase_Homo sapiens_hsa030202.78272714
9Synaptic vesicle cycle_Homo sapiens_hsa047212.51388975
10Vibrio cholerae infection_Homo sapiens_hsa051102.31153380
11Nicotine addiction_Homo sapiens_hsa050332.28154653
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16008701
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.09976924
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.03664092
15Graft-versus-host disease_Homo sapiens_hsa053322.00033762
16Ribosome_Homo sapiens_hsa030101.95901192
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71089226
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65502496
19Primary immunodeficiency_Homo sapiens_hsa053401.64871909
20Cardiac muscle contraction_Homo sapiens_hsa042601.63079832
21Basal transcription factors_Homo sapiens_hsa030221.50430028
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45839375
23Antigen processing and presentation_Homo sapiens_hsa046121.40423147
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37771785
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32815603
26Nucleotide excision repair_Homo sapiens_hsa034201.32230176
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31792911
28Serotonergic synapse_Homo sapiens_hsa047261.25452786
29Pyrimidine metabolism_Homo sapiens_hsa002401.24887092
30GABAergic synapse_Homo sapiens_hsa047271.22271951
31Rheumatoid arthritis_Homo sapiens_hsa053231.22005761
32Fatty acid elongation_Homo sapiens_hsa000621.20642318
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20025459
34Butanoate metabolism_Homo sapiens_hsa006501.17707884
35Selenocompound metabolism_Homo sapiens_hsa004501.16935377
36Steroid biosynthesis_Homo sapiens_hsa001001.16412885
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13257442
38Amphetamine addiction_Homo sapiens_hsa050311.12813764
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12139662
40Sulfur relay system_Homo sapiens_hsa041221.11955326
41Taste transduction_Homo sapiens_hsa047421.11932194
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09594187
43Linoleic acid metabolism_Homo sapiens_hsa005911.08884356
44Mismatch repair_Homo sapiens_hsa034301.08506811
45Vitamin B6 metabolism_Homo sapiens_hsa007501.05576424
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04421864
47Purine metabolism_Homo sapiens_hsa002301.02314317
48Morphine addiction_Homo sapiens_hsa050321.02193327
49Non-homologous end-joining_Homo sapiens_hsa034501.01998707
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01847674
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01802120
52Tryptophan metabolism_Homo sapiens_hsa003801.01315487
53Dopaminergic synapse_Homo sapiens_hsa047281.00378080
54Spliceosome_Homo sapiens_hsa030400.98935200
55Legionellosis_Homo sapiens_hsa051340.95651182
56RNA transport_Homo sapiens_hsa030130.95090179
57Homologous recombination_Homo sapiens_hsa034400.92518863
58One carbon pool by folate_Homo sapiens_hsa006700.92274518
59Nitrogen metabolism_Homo sapiens_hsa009100.91163933
60Long-term potentiation_Homo sapiens_hsa047200.90725686
61Propanoate metabolism_Homo sapiens_hsa006400.90465517
62Olfactory transduction_Homo sapiens_hsa047400.90015292
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.88684606
64Glutamatergic synapse_Homo sapiens_hsa047240.88004174
65Circadian entrainment_Homo sapiens_hsa047130.87637774
66Phagosome_Homo sapiens_hsa041450.86548524
67Regulation of autophagy_Homo sapiens_hsa041400.86291166
68Pyruvate metabolism_Homo sapiens_hsa006200.82679127
69Viral myocarditis_Homo sapiens_hsa054160.81830697
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80948143
71Staphylococcus aureus infection_Homo sapiens_hsa051500.80646775
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79833672
73RNA degradation_Homo sapiens_hsa030180.79757196
74Phototransduction_Homo sapiens_hsa047440.79545196
75Ether lipid metabolism_Homo sapiens_hsa005650.77993196
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77040731
77Cocaine addiction_Homo sapiens_hsa050300.76655697
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76132376
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74442765
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74248808
81Peroxisome_Homo sapiens_hsa041460.73384657
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69590024
83DNA replication_Homo sapiens_hsa030300.68795714
84Hematopoietic cell lineage_Homo sapiens_hsa046400.68574692
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68261312
86Long-term depression_Homo sapiens_hsa047300.68143662
87Type I diabetes mellitus_Homo sapiens_hsa049400.67638817
88Sphingolipid metabolism_Homo sapiens_hsa006000.67359789
89Metabolic pathways_Homo sapiens_hsa011000.66478667
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65710458
91Herpes simplex infection_Homo sapiens_hsa051680.65349085
92Insulin secretion_Homo sapiens_hsa049110.62444168
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61503505
94Oocyte meiosis_Homo sapiens_hsa041140.57395097
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56770474
96Glutathione metabolism_Homo sapiens_hsa004800.55743550
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53856720
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.52598692
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51388105
100Base excision repair_Homo sapiens_hsa034100.48439894
101Epstein-Barr virus infection_Homo sapiens_hsa051690.48049173
102Folate biosynthesis_Homo sapiens_hsa007900.46444443
103Alcoholism_Homo sapiens_hsa050340.46070389
104Systemic lupus erythematosus_Homo sapiens_hsa053220.45857929
105Tuberculosis_Homo sapiens_hsa051520.45480247
106Sulfur metabolism_Homo sapiens_hsa009200.44081326
107Cholinergic synapse_Homo sapiens_hsa047250.43470249
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.42953942
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42116768
110Calcium signaling pathway_Homo sapiens_hsa040200.41815371
111Autoimmune thyroid disease_Homo sapiens_hsa053200.39411137
112Fatty acid metabolism_Homo sapiens_hsa012120.39146251
113Leishmaniasis_Homo sapiens_hsa051400.37878054
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37394633
115Salivary secretion_Homo sapiens_hsa049700.37023419
116beta-Alanine metabolism_Homo sapiens_hsa004100.35725498
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.35148580
118Chemical carcinogenesis_Homo sapiens_hsa052040.34019556
119Fanconi anemia pathway_Homo sapiens_hsa034600.33751232
120Mineral absorption_Homo sapiens_hsa049780.33319648
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32771097
122N-Glycan biosynthesis_Homo sapiens_hsa005100.28962167
123Cell cycle_Homo sapiens_hsa041100.27177626
124Arachidonic acid metabolism_Homo sapiens_hsa005900.26989611
125Fructose and mannose metabolism_Homo sapiens_hsa000510.26952309
126Allograft rejection_Homo sapiens_hsa053300.26908780
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26330887
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26304415
129Gap junction_Homo sapiens_hsa045400.26223992
130Circadian rhythm_Homo sapiens_hsa047100.24969937
131mRNA surveillance pathway_Homo sapiens_hsa030150.24673120
132Carbon metabolism_Homo sapiens_hsa012000.23715025
133Asthma_Homo sapiens_hsa053100.23623780
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.23041707
135Renin secretion_Homo sapiens_hsa049240.22091189
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20837668
137Oxytocin signaling pathway_Homo sapiens_hsa049210.20320723
138Axon guidance_Homo sapiens_hsa043600.18300069
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17270262
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16825014
141Lysosome_Homo sapiens_hsa041420.16244273
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.15474570

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