

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.17926219 |
| 2 | vocalization behavior (GO:0071625) | 4.72499060 |
| 3 | neuron cell-cell adhesion (GO:0007158) | 4.71705112 |
| 4 | layer formation in cerebral cortex (GO:0021819) | 4.59327149 |
| 5 | synaptic vesicle exocytosis (GO:0016079) | 4.57213528 |
| 6 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.56529318 |
| 7 | glutamate secretion (GO:0014047) | 4.53328169 |
| 8 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.49138693 |
| 9 | synaptic vesicle maturation (GO:0016188) | 4.46032297 |
| 10 | nucleobase catabolic process (GO:0046113) | 4.42683055 |
| 11 | locomotory exploration behavior (GO:0035641) | 4.42487266 |
| 12 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.40511785 |
| 13 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.28515576 |
| 14 | protein localization to synapse (GO:0035418) | 4.09906068 |
| 15 | behavioral response to nicotine (GO:0035095) | 4.08743253 |
| 16 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.01588654 |
| 17 | dendritic spine morphogenesis (GO:0060997) | 3.86906532 |
| 18 | auditory behavior (GO:0031223) | 3.82454127 |
| 19 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.77043971 |
| 20 | regulation of synapse structural plasticity (GO:0051823) | 3.69322685 |
| 21 | response to auditory stimulus (GO:0010996) | 3.65179070 |
| 22 | nonmotile primary cilium assembly (GO:0035058) | 3.62060007 |
| 23 | establishment of mitochondrion localization (GO:0051654) | 3.61877301 |
| 24 | axonal fasciculation (GO:0007413) | 3.58268771 |
| 25 | sensory perception of smell (GO:0007608) | 3.58088022 |
| 26 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.57480299 |
| 27 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.57284375 |
| 28 | cellular potassium ion homeostasis (GO:0030007) | 3.56697073 |
| 29 | neuron recognition (GO:0008038) | 3.56003057 |
| 30 | exploration behavior (GO:0035640) | 3.54104194 |
| 31 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.53987879 |
| 32 | gamma-aminobutyric acid transport (GO:0015812) | 3.52733250 |
| 33 | neuronal action potential propagation (GO:0019227) | 3.52292064 |
| 34 | dendrite morphogenesis (GO:0048813) | 3.50975654 |
| 35 | postsynaptic membrane organization (GO:0001941) | 3.49329923 |
| 36 | neurotransmitter secretion (GO:0007269) | 3.46194372 |
| 37 | proline transport (GO:0015824) | 3.43844103 |
| 38 | retinal ganglion cell axon guidance (GO:0031290) | 3.41245000 |
| 39 | long-term memory (GO:0007616) | 3.40441226 |
| 40 | glutamate receptor signaling pathway (GO:0007215) | 3.39279692 |
| 41 | forebrain neuron differentiation (GO:0021879) | 3.35384184 |
| 42 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.32286912 |
| 43 | limb bud formation (GO:0060174) | 3.30831670 |
| 44 | positive regulation of gastrulation (GO:2000543) | 3.30716314 |
| 45 | innervation (GO:0060384) | 3.30222069 |
| 46 | synaptic transmission, glutamatergic (GO:0035249) | 3.30063949 |
| 47 | transmission of nerve impulse (GO:0019226) | 3.28890360 |
| 48 | presynaptic membrane assembly (GO:0097105) | 3.26858469 |
| 49 | epithelial cilium movement (GO:0003351) | 3.26188139 |
| 50 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.25386679 |
| 51 | cell migration in hindbrain (GO:0021535) | 3.24634113 |
| 52 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.22483851 |
| 53 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.21274892 |
| 54 | positive regulation of synapse maturation (GO:0090129) | 3.18784687 |
| 55 | regulation of synaptic vesicle transport (GO:1902803) | 3.15901682 |
| 56 | L-amino acid import (GO:0043092) | 3.14487488 |
| 57 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.12608676 |
| 58 | axon extension involved in axon guidance (GO:0048846) | 3.11686442 |
| 59 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.11686442 |
| 60 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.08210943 |
| 61 | somite development (GO:0061053) | 3.07963158 |
| 62 | cell proliferation in forebrain (GO:0021846) | 3.07342311 |
| 63 | presynaptic membrane organization (GO:0097090) | 3.06274637 |
| 64 | activation of protein kinase A activity (GO:0034199) | 3.04542228 |
| 65 | thalamus development (GO:0021794) | 3.04118187 |
| 66 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.02617875 |
| 67 | mitochondrion transport along microtubule (GO:0047497) | 3.02617875 |
| 68 | neuron-neuron synaptic transmission (GO:0007270) | 3.01157529 |
| 69 | sodium ion export (GO:0071436) | 2.99583077 |
| 70 | spinal cord development (GO:0021510) | 2.99101490 |
| 71 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.99029708 |
| 72 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.96415686 |
| 73 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.95966965 |
| 74 | regulation of cilium movement (GO:0003352) | 2.94461045 |
| 75 | synaptic vesicle endocytosis (GO:0048488) | 2.94320614 |
| 76 | neurotransmitter transport (GO:0006836) | 2.93586252 |
| 77 | central nervous system neuron axonogenesis (GO:0021955) | 2.93192329 |
| 78 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.92464750 |
| 79 | cell communication by electrical coupling (GO:0010644) | 2.91756241 |
| 80 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.90965017 |
| 81 | mechanosensory behavior (GO:0007638) | 2.90349670 |
| 82 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.90145955 |
| 83 | protein polyglutamylation (GO:0018095) | 2.89195984 |
| 84 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.88831084 |
| 85 | detection of calcium ion (GO:0005513) | 2.88466203 |
| 86 | regulation of postsynaptic membrane potential (GO:0060078) | 2.87884637 |
| 87 | regulation of synaptic plasticity (GO:0048167) | 2.86938339 |
| 88 | axon ensheathment in central nervous system (GO:0032291) | 2.86214051 |
| 89 | central nervous system myelination (GO:0022010) | 2.86214051 |
| 90 | positive regulation of membrane potential (GO:0045838) | 2.85985442 |
| 91 | synapse assembly (GO:0007416) | 2.84513349 |
| 92 | hippocampus development (GO:0021766) | 2.84321154 |
| 93 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.81534451 |
| 94 | potassium ion homeostasis (GO:0055075) | 2.78742074 |
| 95 | regulation of neurotransmitter secretion (GO:0046928) | 2.78098164 |
| 96 | olfactory bulb development (GO:0021772) | 2.76733448 |
| 97 | negative regulation of axon guidance (GO:1902668) | 2.76256856 |
| 98 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.75633102 |
| 99 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.75633102 |
| 100 | regulation of synapse maturation (GO:0090128) | 2.75359030 |
| 101 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.75151232 |
| 102 | neuromuscular process controlling balance (GO:0050885) | 2.74131210 |
| 103 | cilium movement (GO:0003341) | 2.73828762 |
| 104 | neuron migration (GO:0001764) | 2.73559776 |
| 105 | ganglion development (GO:0061548) | 2.72746370 |
| 106 | synapse organization (GO:0050808) | 2.71961989 |
| 107 | regulation of collateral sprouting (GO:0048670) | 2.71634223 |
| 108 | adult walking behavior (GO:0007628) | 2.71230814 |
| 109 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.70699794 |
| 110 | startle response (GO:0001964) | 2.70411687 |
| 111 | dendrite development (GO:0016358) | 2.69126302 |
| 112 | short-term memory (GO:0007614) | 2.68198731 |
| 113 | neuronal ion channel clustering (GO:0045161) | 2.68092222 |
| 114 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.67805589 |
| 115 | cerebellar granule cell differentiation (GO:0021707) | 2.67703184 |
| 116 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.67403086 |
| 117 | neuronal stem cell maintenance (GO:0097150) | 2.63908773 |
| 118 | positive regulation of synapse assembly (GO:0051965) | 2.63455159 |
| 119 | long-term synaptic potentiation (GO:0060291) | 2.62615712 |
| 120 | regulation of vesicle fusion (GO:0031338) | 2.62488571 |
| 121 | regulation of neurotransmitter levels (GO:0001505) | 2.61612578 |
| 122 | positive regulation of dendritic spine development (GO:0060999) | 2.60848648 |
| 123 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.60768819 |
| 124 | prepulse inhibition (GO:0060134) | 2.59323233 |
| 125 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.58391516 |
| 126 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.58273636 |
| 127 | positive regulation of synaptic transmission (GO:0050806) | 2.58262401 |
| 128 | ephrin receptor signaling pathway (GO:0048013) | 2.57639466 |
| 129 | potassium ion import (GO:0010107) | 2.57259861 |
| 130 | learning (GO:0007612) | 2.57073639 |
| 131 | positive regulation of action potential (GO:0045760) | 2.56580658 |
| 132 | regulation of microtubule-based movement (GO:0060632) | 2.56459231 |
| 133 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.56243072 |
| 134 | intraspecies interaction between organisms (GO:0051703) | 2.56215242 |
| 135 | social behavior (GO:0035176) | 2.56215242 |
| 136 | axon extension (GO:0048675) | 2.55810162 |
| 137 | mating behavior (GO:0007617) | 2.55542346 |
| 138 | regulation of synapse assembly (GO:0051963) | 2.54457991 |
| 139 | regulation of axon guidance (GO:1902667) | 2.54289874 |
| 140 | spinal cord association neuron differentiation (GO:0021527) | 2.52859227 |
| 141 | axonemal dynein complex assembly (GO:0070286) | 2.51974257 |
| 142 | intraciliary transport (GO:0042073) | 2.51369247 |
| 143 | neuromuscular synaptic transmission (GO:0007274) | 2.49561438 |
| 144 | paraxial mesoderm development (GO:0048339) | 2.48268261 |
| 145 | dopaminergic neuron differentiation (GO:0071542) | 2.47177085 |
| 146 | negative regulation of axon extension (GO:0030517) | 2.45538968 |
| 147 | regulation of feeding behavior (GO:0060259) | 2.43437419 |
| 148 | behavioral defense response (GO:0002209) | 2.41820989 |
| 149 | behavioral fear response (GO:0001662) | 2.41820989 |
| 150 | establishment of tissue polarity (GO:0007164) | 2.41499323 |
| 151 | establishment of planar polarity (GO:0001736) | 2.41499323 |
| 152 | appendage development (GO:0048736) | 2.41118047 |
| 153 | limb development (GO:0060173) | 2.41118047 |
| 154 | synaptic transmission, cholinergic (GO:0007271) | 2.40755809 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.54955787 |
| 2 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.71707981 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.14274929 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.13088079 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.06071057 |
| 6 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.95608895 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.90419674 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.90419674 |
| 9 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.83073975 |
| 10 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.73585815 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.70234059 |
| 12 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.67428611 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.65732831 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.57632017 |
| 15 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.51037402 |
| 16 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.43936095 |
| 17 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.34852425 |
| 18 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.32566491 |
| 19 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.32179640 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.31988955 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.30362752 |
| 22 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.20592278 |
| 23 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.19622122 |
| 24 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.89017634 |
| 25 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.87049516 |
| 26 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.80257917 |
| 27 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.78780334 |
| 28 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.78345969 |
| 29 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.71944451 |
| 30 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.71221255 |
| 31 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.70979277 |
| 32 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.70317961 |
| 33 | FUS_26573619_Chip-Seq_HEK293_Human | 1.69709092 |
| 34 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.69164406 |
| 35 | VDR_22108803_ChIP-Seq_LS180_Human | 1.67422644 |
| 36 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.65539947 |
| 37 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.62687616 |
| 38 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.62431204 |
| 39 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.55456164 |
| 40 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.54565938 |
| 41 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.54277006 |
| 42 | EWS_26573619_Chip-Seq_HEK293_Human | 1.51324109 |
| 43 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.49378544 |
| 44 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.48006880 |
| 45 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.46271319 |
| 46 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.45662273 |
| 47 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.44715965 |
| 48 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.39950272 |
| 49 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.39276867 |
| 50 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.38300825 |
| 51 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.36464700 |
| 52 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.36421278 |
| 53 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.31151558 |
| 54 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.30696758 |
| 55 | P300_19829295_ChIP-Seq_ESCs_Human | 1.29642897 |
| 56 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.28941778 |
| 57 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.28121547 |
| 58 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.27067111 |
| 59 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.26238763 |
| 60 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.25739634 |
| 61 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.25628376 |
| 62 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.22474345 |
| 63 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.22149172 |
| 64 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.21686633 |
| 65 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.19956024 |
| 66 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.19907485 |
| 67 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.19304422 |
| 68 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.18927479 |
| 69 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.18739427 |
| 70 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.18268555 |
| 71 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.16940419 |
| 72 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.15591700 |
| 73 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.14162759 |
| 74 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.14159642 |
| 75 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.14120272 |
| 76 | AR_19668381_ChIP-Seq_PC3_Human | 1.14041952 |
| 77 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.11586916 |
| 78 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.11124777 |
| 79 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.11089851 |
| 80 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.10706770 |
| 81 | KDM2B_26808549_Chip-Seq_K562_Human | 1.10379771 |
| 82 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.10262057 |
| 83 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.08569813 |
| 84 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.08453635 |
| 85 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.07716952 |
| 86 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.07359142 |
| 87 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.05871494 |
| 88 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.05189360 |
| 89 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.04660172 |
| 90 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.04497425 |
| 91 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03549621 |
| 92 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.01265976 |
| 93 | STAT3_23295773_ChIP-Seq_U87_Human | 1.01192057 |
| 94 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.00739692 |
| 95 | AR_25329375_ChIP-Seq_VCAP_Human | 1.00695565 |
| 96 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.98348876 |
| 97 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97259372 |
| 98 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.96748257 |
| 99 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.96340571 |
| 100 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.96030212 |
| 101 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.95949183 |
| 102 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 0.95879441 |
| 103 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.95842450 |
| 104 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 0.95171972 |
| 105 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.95069567 |
| 106 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.93954400 |
| 107 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.93890915 |
| 108 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93382806 |
| 109 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.93198600 |
| 110 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.92893231 |
| 111 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.92564729 |
| 112 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.92564729 |
| 113 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.92367281 |
| 114 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.92215104 |
| 115 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.91282314 |
| 116 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.90844108 |
| 117 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.90497750 |
| 118 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.90399878 |
| 119 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.90175352 |
| 120 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.89556405 |
| 121 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.88987664 |
| 122 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.88508012 |
| 123 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.87663423 |
| 124 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.87405199 |
| 125 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.86799523 |
| 126 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.86495479 |
| 127 | TCF4_23295773_ChIP-Seq_U87_Human | 0.85744320 |
| 128 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.84594465 |
| 129 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.82453685 |
| 130 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.82030593 |
| 131 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.81052960 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.28498262 |
| 2 | MP0003880_abnormal_central_pattern | 4.01933785 |
| 3 | MP0004270_analgesia | 3.62427636 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.52413901 |
| 5 | MP0001968_abnormal_touch/_nociception | 3.03193677 |
| 6 | MP0001984_abnormal_olfaction | 2.87028203 |
| 7 | MP0002063_abnormal_learning/memory/cond | 2.78432533 |
| 8 | MP0009745_abnormal_behavioral_response | 2.72902840 |
| 9 | MP0001486_abnormal_startle_reflex | 2.72116331 |
| 10 | MP0005423_abnormal_somatic_nervous | 2.63443351 |
| 11 | MP0002734_abnormal_mechanical_nocicepti | 2.59495305 |
| 12 | MP0002064_seizures | 2.57224685 |
| 13 | MP0002736_abnormal_nociception_after | 2.51052300 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.48781343 |
| 15 | MP0009046_muscle_twitch | 2.42280153 |
| 16 | MP0000778_abnormal_nervous_system | 2.39120083 |
| 17 | MP0002735_abnormal_chemical_nociception | 2.36852903 |
| 18 | MP0004858_abnormal_nervous_system | 2.17550222 |
| 19 | MP0002272_abnormal_nervous_system | 2.13501520 |
| 20 | MP0002184_abnormal_innervation | 2.06123841 |
| 21 | MP0002733_abnormal_thermal_nociception | 2.04831523 |
| 22 | MP0001970_abnormal_pain_threshold | 2.03656896 |
| 23 | MP0001440_abnormal_grooming_behavior | 2.01209814 |
| 24 | MP0003329_amyloid_beta_deposits | 1.95400517 |
| 25 | MP0003890_abnormal_embryonic-extraembry | 1.91668735 |
| 26 | MP0010386_abnormal_urinary_bladder | 1.84983094 |
| 27 | MP0002557_abnormal_social/conspecific_i | 1.81972549 |
| 28 | MP0009780_abnormal_chondrocyte_physiolo | 1.81771669 |
| 29 | MP0002067_abnormal_sensory_capabilities | 1.79023956 |
| 30 | MP0001293_anophthalmia | 1.76957071 |
| 31 | MP0003121_genomic_imprinting | 1.73453704 |
| 32 | MP0004133_heterotaxia | 1.67317127 |
| 33 | MP0001501_abnormal_sleep_pattern | 1.65618085 |
| 34 | MP0008569_lethality_at_weaning | 1.61374572 |
| 35 | MP0002882_abnormal_neuron_morphology | 1.60248362 |
| 36 | MP0000955_abnormal_spinal_cord | 1.60136316 |
| 37 | MP0001502_abnormal_circadian_rhythm | 1.59703687 |
| 38 | MP0004742_abnormal_vestibular_system | 1.59241435 |
| 39 | MP0006276_abnormal_autonomic_nervous | 1.56782392 |
| 40 | MP0009379_abnormal_foot_pigmentation | 1.55548558 |
| 41 | MP0005499_abnormal_olfactory_system | 1.47565767 |
| 42 | MP0005394_taste/olfaction_phenotype | 1.47565767 |
| 43 | MP0004811_abnormal_neuron_physiology | 1.46470040 |
| 44 | MP0004885_abnormal_endolymph | 1.46354250 |
| 45 | MP0005551_abnormal_eye_electrophysiolog | 1.38136924 |
| 46 | MP0005646_abnormal_pituitary_gland | 1.35319365 |
| 47 | MP0005386_behavior/neurological_phenoty | 1.34861547 |
| 48 | MP0004924_abnormal_behavior | 1.34861547 |
| 49 | MP0003119_abnormal_digestive_system | 1.33525221 |
| 50 | MP0010030_abnormal_orbit_morphology | 1.30509666 |
| 51 | MP0002233_abnormal_nose_morphology | 1.30200151 |
| 52 | MP0003937_abnormal_limbs/digits/tail_de | 1.29166030 |
| 53 | MP0003634_abnormal_glial_cell | 1.28400527 |
| 54 | MP0002938_white_spotting | 1.26296835 |
| 55 | MP0002066_abnormal_motor_capabilities/c | 1.26217493 |
| 56 | MP0002152_abnormal_brain_morphology | 1.24367086 |
| 57 | MP0002752_abnormal_somatic_nervous | 1.22423832 |
| 58 | MP0005623_abnormal_meninges_morphology | 1.21854931 |
| 59 | MP0000569_abnormal_digit_pigmentation | 1.21779205 |
| 60 | MP0001485_abnormal_pinna_reflex | 1.20657465 |
| 61 | MP0001905_abnormal_dopamine_level | 1.18703590 |
| 62 | MP0003385_abnormal_body_wall | 1.18347090 |
| 63 | MP0002234_abnormal_pharynx_morphology | 1.17878254 |
| 64 | MP0003942_abnormal_urinary_system | 1.16308359 |
| 65 | MP0003011_delayed_dark_adaptation | 1.14987543 |
| 66 | MP0003123_paternal_imprinting | 1.14969680 |
| 67 | MP0003879_abnormal_hair_cell | 1.14875670 |
| 68 | MP0001286_abnormal_eye_development | 1.14273541 |
| 69 | MP0001963_abnormal_hearing_physiology | 1.13844121 |
| 70 | MP0008789_abnormal_olfactory_epithelium | 1.13810361 |
| 71 | MP0003755_abnormal_palate_morphology | 1.12226809 |
| 72 | MP0003633_abnormal_nervous_system | 1.09634915 |
| 73 | MP0002751_abnormal_autonomic_nervous | 1.09170568 |
| 74 | MP0003690_abnormal_glial_cell | 1.08963017 |
| 75 | MP0002909_abnormal_adrenal_gland | 1.08363787 |
| 76 | MP0000026_abnormal_inner_ear | 1.06883948 |
| 77 | MP0002254_reproductive_system_inflammat | 1.05708011 |
| 78 | MP0005187_abnormal_penis_morphology | 1.04490853 |
| 79 | MP0003136_yellow_coat_color | 1.03974679 |
| 80 | MP0002697_abnormal_eye_size | 1.03437052 |
| 81 | MP0002102_abnormal_ear_morphology | 1.01249310 |
| 82 | MP0000604_amyloidosis | 1.00878336 |
| 83 | MP0003631_nervous_system_phenotype | 1.00820273 |
| 84 | MP0002229_neurodegeneration | 0.98084805 |
| 85 | MP0004145_abnormal_muscle_electrophysio | 0.96964062 |
| 86 | MP0000920_abnormal_myelination | 0.96027392 |
| 87 | MP0000537_abnormal_urethra_morphology | 0.95203566 |
| 88 | MP0008877_abnormal_DNA_methylation | 0.94005532 |
| 89 | MP0002822_catalepsy | 0.92306685 |
| 90 | MP0003787_abnormal_imprinting | 0.91628504 |
| 91 | MP0003632_abnormal_nervous_system | 0.91100455 |
| 92 | MP0001177_atelectasis | 0.90682504 |
| 93 | MP0001529_abnormal_vocalization | 0.90497147 |
| 94 | MP0000751_myopathy | 0.90459159 |
| 95 | MP0005391_vision/eye_phenotype | 0.88705095 |
| 96 | MP0010234_abnormal_vibrissa_follicle | 0.87908450 |
| 97 | MP0003938_abnormal_ear_development | 0.86786245 |
| 98 | MP0004142_abnormal_muscle_tone | 0.86136223 |
| 99 | MP0002638_abnormal_pupillary_reflex | 0.85428965 |
| 100 | MP0008995_early_reproductive_senescence | 0.84405474 |
| 101 | MP0003315_abnormal_perineum_morphology | 0.83586075 |
| 102 | MP0002081_perinatal_lethality | 0.82963551 |
| 103 | MP0002653_abnormal_ependyma_morphology | 0.82904616 |
| 104 | MP0003935_abnormal_craniofacial_develop | 0.82628744 |
| 105 | MP0003283_abnormal_digestive_organ | 0.82528831 |
| 106 | MP0005645_abnormal_hypothalamus_physiol | 0.82195988 |
| 107 | MP0000631_abnormal_neuroendocrine_gland | 0.81382144 |
| 108 | MP0002092_abnormal_eye_morphology | 0.81327367 |
| 109 | MP0002116_abnormal_craniofacial_bone | 0.80776023 |
| 110 | MP0005248_abnormal_Harderian_gland | 0.80486191 |
| 111 | MP0003861_abnormal_nervous_system | 0.80382735 |
| 112 | MP0009250_abnormal_appendicular_skeleto | 0.78519085 |
| 113 | MP0001664_abnormal_digestion | 0.78184371 |
| 114 | MP0006072_abnormal_retinal_apoptosis | 0.77101487 |
| 115 | MP0002090_abnormal_vision | 0.75583210 |
| 116 | MP0006292_abnormal_olfactory_placode | 0.74998775 |
| 117 | MP0000566_synostosis | 0.74068253 |
| 118 | MP0005253_abnormal_eye_physiology | 0.73801758 |
| 119 | MP0003075_altered_response_to | 0.72046100 |
| 120 | MP0001188_hyperpigmentation | 0.71787673 |
| 121 | MP0001299_abnormal_eye_distance/ | 0.70502291 |
| 122 | MP0000534_abnormal_ureter_morphology | 0.69151688 |
| 123 | MP0002249_abnormal_larynx_morphology | 0.68654242 |
| 124 | MP0005195_abnormal_posterior_eye | 0.68504320 |
| 125 | MP0003122_maternal_imprinting | 0.67228881 |
| 126 | MP0002069_abnormal_eating/drinking_beha | 0.67158106 |
| 127 | MP0003137_abnormal_impulse_conducting | 0.65248231 |
| 128 | MP0004085_abnormal_heartbeat | 0.65039521 |
| 129 | MP0008874_decreased_physiological_sensi | 0.64359828 |
| 130 | MP0000049_abnormal_middle_ear | 0.63257402 |
| 131 | MP0008961_abnormal_basal_metabolism | 0.61890402 |
| 132 | MP0004484_altered_response_of | 0.59319925 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 5.71603389 |
| 2 | Myokymia (HP:0002411) | 5.51919028 |
| 3 | Megalencephaly (HP:0001355) | 4.32297570 |
| 4 | Focal seizures (HP:0007359) | 4.27596429 |
| 5 | Epileptic encephalopathy (HP:0200134) | 3.98859147 |
| 6 | Visual hallucinations (HP:0002367) | 3.90228234 |
| 7 | Supranuclear gaze palsy (HP:0000605) | 3.70287763 |
| 8 | Septo-optic dysplasia (HP:0100842) | 3.50942995 |
| 9 | Atonic seizures (HP:0010819) | 3.46505013 |
| 10 | Febrile seizures (HP:0002373) | 3.37338491 |
| 11 | Neurofibrillary tangles (HP:0002185) | 3.29731153 |
| 12 | Progressive cerebellar ataxia (HP:0002073) | 3.29218121 |
| 13 | Absence seizures (HP:0002121) | 3.12572247 |
| 14 | Hepatoblastoma (HP:0002884) | 3.10378990 |
| 15 | Generalized tonic-clonic seizures (HP:0002069) | 3.07231041 |
| 16 | Action tremor (HP:0002345) | 3.04331101 |
| 17 | Abnormal ciliary motility (HP:0012262) | 2.97005068 |
| 18 | Ankle clonus (HP:0011448) | 2.96997131 |
| 19 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.90391678 |
| 20 | Broad-based gait (HP:0002136) | 2.87097968 |
| 21 | Mutism (HP:0002300) | 2.86485540 |
| 22 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.85344162 |
| 23 | Hyperventilation (HP:0002883) | 2.84270978 |
| 24 | Cerebral inclusion bodies (HP:0100314) | 2.80836742 |
| 25 | Optic nerve hypoplasia (HP:0000609) | 2.79055491 |
| 26 | Dialeptic seizures (HP:0011146) | 2.76707991 |
| 27 | Cortical dysplasia (HP:0002539) | 2.73156235 |
| 28 | True hermaphroditism (HP:0010459) | 2.72525344 |
| 29 | Diplopia (HP:0000651) | 2.71712199 |
| 30 | Abnormality of binocular vision (HP:0011514) | 2.71712199 |
| 31 | Limb dystonia (HP:0002451) | 2.71475617 |
| 32 | Hemiparesis (HP:0001269) | 2.59384366 |
| 33 | Absent/shortened dynein arms (HP:0200106) | 2.59171527 |
| 34 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.59171527 |
| 35 | Hemiplegia (HP:0002301) | 2.56815184 |
| 36 | Nephronophthisis (HP:0000090) | 2.55083548 |
| 37 | Molar tooth sign on MRI (HP:0002419) | 2.53063028 |
| 38 | Abnormality of midbrain morphology (HP:0002418) | 2.53063028 |
| 39 | Depression (HP:0000716) | 2.50577009 |
| 40 | Gait imbalance (HP:0002141) | 2.49378035 |
| 41 | Pancreatic fibrosis (HP:0100732) | 2.48874555 |
| 42 | Amblyopia (HP:0000646) | 2.48626284 |
| 43 | Abnormality of the corticospinal tract (HP:0002492) | 2.48585919 |
| 44 | Truncal ataxia (HP:0002078) | 2.47798528 |
| 45 | Termporal pattern (HP:0011008) | 2.45257780 |
| 46 | Insidious onset (HP:0003587) | 2.45257780 |
| 47 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.44569269 |
| 48 | Aplasia of the phalanges of the hand (HP:0009802) | 2.44569269 |
| 49 | Aplasia involving bones of the extremities (HP:0009825) | 2.44569269 |
| 50 | Abnormality of the labia minora (HP:0012880) | 2.43979834 |
| 51 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.43055469 |
| 52 | Arterial tortuosity (HP:0005116) | 2.42593098 |
| 53 | Nephrogenic diabetes insipidus (HP:0009806) | 2.42221774 |
| 54 | Retinal dysplasia (HP:0007973) | 2.39302283 |
| 55 | Rib fusion (HP:0000902) | 2.39291442 |
| 56 | Spastic gait (HP:0002064) | 2.37868664 |
| 57 | Dysmetria (HP:0001310) | 2.35934532 |
| 58 | Pancreatic cysts (HP:0001737) | 2.35147101 |
| 59 | Apathy (HP:0000741) | 2.28687258 |
| 60 | Anxiety (HP:0000739) | 2.25335108 |
| 61 | Maternal diabetes (HP:0009800) | 2.22762884 |
| 62 | Excessive salivation (HP:0003781) | 2.22345923 |
| 63 | Drooling (HP:0002307) | 2.22345923 |
| 64 | Cutaneous finger syndactyly (HP:0010554) | 2.22255855 |
| 65 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.22232718 |
| 66 | Anophthalmia (HP:0000528) | 2.22112791 |
| 67 | Abnormal eating behavior (HP:0100738) | 2.21888875 |
| 68 | Lissencephaly (HP:0001339) | 2.20725322 |
| 69 | Postaxial hand polydactyly (HP:0001162) | 2.19385600 |
| 70 | Stereotypic behavior (HP:0000733) | 2.17977161 |
| 71 | Aqueductal stenosis (HP:0002410) | 2.16285168 |
| 72 | Supernumerary spleens (HP:0009799) | 2.15473349 |
| 73 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.15122875 |
| 74 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.15122875 |
| 75 | Dysdiadochokinesis (HP:0002075) | 2.11998373 |
| 76 | Absent septum pellucidum (HP:0001331) | 2.11763345 |
| 77 | Torticollis (HP:0000473) | 2.11229647 |
| 78 | Obstructive sleep apnea (HP:0002870) | 2.10101033 |
| 79 | Papilledema (HP:0001085) | 2.09348531 |
| 80 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.09089128 |
| 81 | Agitation (HP:0000713) | 2.08357758 |
| 82 | Exotropia (HP:0000577) | 2.08345381 |
| 83 | Anencephaly (HP:0002323) | 2.08135294 |
| 84 | Vascular tortuosity (HP:0004948) | 2.06846536 |
| 85 | Syncope (HP:0001279) | 2.06720077 |
| 86 | Lower limb muscle weakness (HP:0007340) | 2.06195421 |
| 87 | Sleep apnea (HP:0010535) | 2.05766386 |
| 88 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.05383146 |
| 89 | Short 4th metacarpal (HP:0010044) | 2.05383146 |
| 90 | Sclerocornea (HP:0000647) | 2.05260781 |
| 91 | Chronic hepatic failure (HP:0100626) | 2.04428871 |
| 92 | Poor eye contact (HP:0000817) | 2.04384761 |
| 93 | Insomnia (HP:0100785) | 2.03345236 |
| 94 | Intestinal atresia (HP:0011100) | 2.01339500 |
| 95 | Bronchomalacia (HP:0002780) | 2.00782813 |
| 96 | Rhinitis (HP:0012384) | 2.00034054 |
| 97 | Poor coordination (HP:0002370) | 1.99452512 |
| 98 | Cutaneous syndactyly (HP:0012725) | 1.99317539 |
| 99 | Abnormality of the renal medulla (HP:0100957) | 1.99174530 |
| 100 | Diminished motivation (HP:0000745) | 1.98665728 |
| 101 | Congenital primary aphakia (HP:0007707) | 1.96541957 |
| 102 | Anosmia (HP:0000458) | 1.95964054 |
| 103 | Abnormality of the diencephalon (HP:0010662) | 1.95307762 |
| 104 | Urinary urgency (HP:0000012) | 1.95132418 |
| 105 | Specific learning disability (HP:0001328) | 1.95036927 |
| 106 | Intention tremor (HP:0002080) | 1.92368193 |
| 107 | Synostosis involving the elbow (HP:0003938) | 1.91952863 |
| 108 | Humeroradial synostosis (HP:0003041) | 1.91952863 |
| 109 | Prolonged QT interval (HP:0001657) | 1.91438068 |
| 110 | Narrow nasal bridge (HP:0000446) | 1.91120286 |
| 111 | Vaginal atresia (HP:0000148) | 1.90267039 |
| 112 | Shawl scrotum (HP:0000049) | 1.89820582 |
| 113 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.89287618 |
| 114 | Hypoplasia of the brainstem (HP:0002365) | 1.89287618 |
| 115 | Genital tract atresia (HP:0001827) | 1.88833050 |
| 116 | Hypoventilation (HP:0002791) | 1.87865986 |
| 117 | Renal hypoplasia (HP:0000089) | 1.87422031 |
| 118 | Postaxial foot polydactyly (HP:0001830) | 1.86780450 |
| 119 | Pachygyria (HP:0001302) | 1.86733761 |
| 120 | Akinesia (HP:0002304) | 1.86129861 |
| 121 | Genetic anticipation (HP:0003743) | 1.86086963 |
| 122 | Gaze-evoked nystagmus (HP:0000640) | 1.85321451 |
| 123 | Impaired social interactions (HP:0000735) | 1.84592485 |
| 124 | Abnormal social behavior (HP:0012433) | 1.84592485 |
| 125 | Occipital encephalocele (HP:0002085) | 1.84006395 |
| 126 | Inappropriate behavior (HP:0000719) | 1.83780395 |
| 127 | Focal dystonia (HP:0004373) | 1.82824676 |
| 128 | Epileptiform EEG discharges (HP:0011182) | 1.82026189 |
| 129 | Polyphagia (HP:0002591) | 1.81965325 |
| 130 | Morphological abnormality of the middle ear (HP:0008609) | 1.81801821 |
| 131 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.81474500 |
| 132 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.81474500 |
| 133 | Cystic liver disease (HP:0006706) | 1.79579375 |
| 134 | Medial flaring of the eyebrow (HP:0010747) | 1.77876869 |
| 135 | Growth hormone deficiency (HP:0000824) | 1.76565024 |
| 136 | EEG with generalized epileptiform discharges (HP:0011198) | 1.76431945 |
| 137 | Abnormality of the 4th metacarpal (HP:0010012) | 1.75525853 |
| 138 | Abnormality of macular pigmentation (HP:0008002) | 1.75040352 |
| 139 | Colon cancer (HP:0003003) | 1.74948169 |
| 140 | Type II lissencephaly (HP:0007260) | 1.74597262 |
| 141 | Bilateral microphthalmos (HP:0007633) | 1.74149856 |
| 142 | Narrow forehead (HP:0000341) | 1.74136503 |
| 143 | Preaxial foot polydactyly (HP:0001841) | 1.73721343 |
| 144 | Esophageal atresia (HP:0002032) | 1.73627159 |
| 145 | Gastrointestinal atresia (HP:0002589) | 1.72516484 |
| 146 | Generalized myoclonic seizures (HP:0002123) | 1.71635547 |
| 147 | Scanning speech (HP:0002168) | 1.71113881 |
| 148 | Neoplasm of the heart (HP:0100544) | 1.70241413 |
| 149 | Abnormality of salivation (HP:0100755) | 1.70027789 |
| 150 | Preaxial hand polydactyly (HP:0001177) | 1.69831825 |
| 151 | Ventricular fibrillation (HP:0001663) | 1.69543734 |
| 152 | Abnormality of the septum pellucidum (HP:0007375) | 1.68648077 |
| 153 | Midline defect of the nose (HP:0004122) | 1.68200267 |
| 154 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.67839363 |
| 155 | Vitreoretinal degeneration (HP:0000655) | 1.66824406 |
| 156 | Micropenis (HP:0000054) | 1.66737264 |
| 157 | Tubular atrophy (HP:0000092) | 1.65410496 |
| 158 | Broad foot (HP:0001769) | 1.63181470 |
| 159 | Oligodactyly (hands) (HP:0001180) | 1.61732108 |
| 160 | High anterior hairline (HP:0009890) | 1.58770401 |
| 161 | Patellar aplasia (HP:0006443) | 1.57829016 |
| 162 | Pendular nystagmus (HP:0012043) | 1.57739725 |
| 163 | Oligodactyly (HP:0012165) | 1.57090803 |
| 164 | Anterior segment dysgenesis (HP:0007700) | 1.56953200 |
| 165 | Spastic tetraplegia (HP:0002510) | 1.56793450 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 3.91728276 |
| 2 | EPHA4 | 3.82073776 |
| 3 | NTRK3 | 3.57893027 |
| 4 | NTRK2 | 2.82662183 |
| 5 | MAP3K4 | 2.70596180 |
| 6 | MINK1 | 2.59074439 |
| 7 | TNIK | 2.45256584 |
| 8 | MAP3K9 | 2.36198350 |
| 9 | BCR | 2.33893277 |
| 10 | MAP2K7 | 2.23878141 |
| 11 | CASK | 2.14010895 |
| 12 | PHKG2 | 2.10672654 |
| 13 | PHKG1 | 2.10672654 |
| 14 | PAK6 | 2.02525699 |
| 15 | NTRK1 | 1.98720550 |
| 16 | DAPK2 | 1.98430539 |
| 17 | WNK3 | 1.94797204 |
| 18 | MAPK13 | 1.80907104 |
| 19 | PRKD3 | 1.75029818 |
| 20 | DYRK3 | 1.74758485 |
| 21 | PNCK | 1.59571799 |
| 22 | SIK2 | 1.52765936 |
| 23 | MAP2K4 | 1.50658328 |
| 24 | CDK5 | 1.48491909 |
| 25 | GRK5 | 1.45653466 |
| 26 | MAPK15 | 1.45577110 |
| 27 | MKNK2 | 1.44346218 |
| 28 | LMTK2 | 1.43873492 |
| 29 | DYRK1B | 1.41502853 |
| 30 | UHMK1 | 1.40314593 |
| 31 | LATS2 | 1.35808075 |
| 32 | KSR1 | 1.34479313 |
| 33 | STK38 | 1.34003575 |
| 34 | TYRO3 | 1.32339171 |
| 35 | MAP3K12 | 1.28236482 |
| 36 | PAK3 | 1.27379225 |
| 37 | EPHB2 | 1.24746024 |
| 38 | FGFR2 | 1.19739890 |
| 39 | TRIM28 | 1.17903787 |
| 40 | CSNK1G2 | 1.14093663 |
| 41 | PRKCG | 1.13525023 |
| 42 | KSR2 | 1.13174640 |
| 43 | ERBB3 | 1.11685476 |
| 44 | FER | 1.11144335 |
| 45 | PLK2 | 1.09626781 |
| 46 | CAMKK1 | 1.09346397 |
| 47 | MKNK1 | 1.07149980 |
| 48 | CDK19 | 1.03343242 |
| 49 | STK38L | 1.01001180 |
| 50 | DMPK | 1.00013256 |
| 51 | TAF1 | 0.98821489 |
| 52 | WNK4 | 0.94229839 |
| 53 | EPHA3 | 0.93911131 |
| 54 | DYRK1A | 0.93797908 |
| 55 | CAMK2A | 0.92281890 |
| 56 | MAPK12 | 0.91015299 |
| 57 | SGK2 | 0.88669331 |
| 58 | CSNK1G1 | 0.87715717 |
| 59 | RIPK1 | 0.85558383 |
| 60 | RET | 0.85471638 |
| 61 | ICK | 0.85272959 |
| 62 | MARK2 | 0.84304029 |
| 63 | PRPF4B | 0.83648751 |
| 64 | RPS6KA4 | 0.82849167 |
| 65 | CDK18 | 0.82717655 |
| 66 | STK11 | 0.82537921 |
| 67 | CDK15 | 0.82533802 |
| 68 | CAMK2B | 0.81150451 |
| 69 | CDK14 | 0.79953227 |
| 70 | OXSR1 | 0.79772388 |
| 71 | SGK223 | 0.79155965 |
| 72 | SGK494 | 0.79155965 |
| 73 | NEK6 | 0.78758553 |
| 74 | CDC7 | 0.76724985 |
| 75 | BCKDK | 0.73880880 |
| 76 | DAPK1 | 0.73757735 |
| 77 | DYRK2 | 0.72921274 |
| 78 | CDK11A | 0.72438711 |
| 79 | DDR2 | 0.70948446 |
| 80 | PRKCH | 0.70619303 |
| 81 | CSNK1A1L | 0.70568716 |
| 82 | CSNK1G3 | 0.70293794 |
| 83 | IRAK2 | 0.68461462 |
| 84 | CAMK1 | 0.68442820 |
| 85 | ADRBK2 | 0.68203589 |
| 86 | BMPR1B | 0.68138455 |
| 87 | MAP3K2 | 0.67902372 |
| 88 | ROCK2 | 0.66563734 |
| 89 | PKN1 | 0.65572710 |
| 90 | MAP4K2 | 0.65381707 |
| 91 | ZAK | 0.65345745 |
| 92 | FGR | 0.63144174 |
| 93 | VRK1 | 0.62964519 |
| 94 | CAMK1G | 0.62942176 |
| 95 | STK39 | 0.62436552 |
| 96 | CDC42BPA | 0.61517983 |
| 97 | PRKCE | 0.59821682 |
| 98 | ERBB2 | 0.58992216 |
| 99 | FYN | 0.58708344 |
| 100 | LIMK1 | 0.58341496 |
| 101 | CAMK2D | 0.57919192 |
| 102 | SRPK1 | 0.57208338 |
| 103 | TNK2 | 0.56725506 |
| 104 | MYLK | 0.56591759 |
| 105 | RIPK4 | 0.54860078 |
| 106 | TAOK1 | 0.53844767 |
| 107 | NEK2 | 0.53517190 |
| 108 | WEE1 | 0.53221149 |
| 109 | ROCK1 | 0.51797864 |
| 110 | CAMK2G | 0.51092519 |
| 111 | PRKCZ | 0.50899809 |
| 112 | CAMK4 | 0.49126724 |
| 113 | FES | 0.49001971 |
| 114 | ARAF | 0.47977929 |
| 115 | PLK4 | 0.47524200 |
| 116 | CSNK1E | 0.46884540 |
| 117 | SIK3 | 0.45601930 |
| 118 | MAP3K10 | 0.45423527 |
| 119 | SGK1 | 0.45160227 |
| 120 | BMPR2 | 0.44709737 |
| 121 | CSNK1A1 | 0.44289680 |
| 122 | MAP3K6 | 0.44002220 |
| 123 | PDGFRA | 0.42610269 |
| 124 | PLK3 | 0.41585169 |
| 125 | GRK1 | 0.40367235 |
| 126 | PDPK1 | 0.39631486 |
| 127 | INSRR | 0.37997312 |
| 128 | MUSK | 0.37955148 |
| 129 | CDK3 | 0.37908088 |
| 130 | FGFR1 | 0.37789329 |
| 131 | PRKACA | 0.37429302 |
| 132 | RPS6KA2 | 0.36999512 |
| 133 | PINK1 | 0.36617353 |
| 134 | WNK1 | 0.36316149 |
| 135 | VRK2 | 0.34772461 |
| 136 | PLK1 | 0.34147910 |
| 137 | AKT3 | 0.32480886 |
| 138 | NME1 | 0.32397712 |
| 139 | PRKG1 | 0.30736746 |
| 140 | PRKACB | 0.30492339 |
| 141 | TIE1 | 0.30272771 |
| 142 | ERBB4 | 0.29790757 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Olfactory transduction_Homo sapiens_hsa04740 | 3.44711073 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 3.01795833 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.67769563 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.50986239 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.47262279 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.46327121 |
| 7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.43199114 |
| 8 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.37454250 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.29640441 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 2.28030486 |
| 11 | Salivary secretion_Homo sapiens_hsa04970 | 2.07209444 |
| 12 | Insulin secretion_Homo sapiens_hsa04911 | 1.94166400 |
| 13 | Long-term potentiation_Homo sapiens_hsa04720 | 1.94086501 |
| 14 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.91990957 |
| 15 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.91973248 |
| 16 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.87447024 |
| 17 | Phototransduction_Homo sapiens_hsa04744 | 1.84845221 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.73612577 |
| 19 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.72697087 |
| 20 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.72116682 |
| 21 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.68105592 |
| 22 | Taste transduction_Homo sapiens_hsa04742 | 1.64420393 |
| 23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.62186851 |
| 24 | Ribosome_Homo sapiens_hsa03010 | 1.61337780 |
| 25 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.58687845 |
| 26 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.57104347 |
| 27 | Axon guidance_Homo sapiens_hsa04360 | 1.56462376 |
| 28 | Renin secretion_Homo sapiens_hsa04924 | 1.53600990 |
| 29 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.49121759 |
| 30 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.46521552 |
| 31 | Cocaine addiction_Homo sapiens_hsa05030 | 1.45043120 |
| 32 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.39899018 |
| 33 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.38968296 |
| 34 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.36196516 |
| 35 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.35556939 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.35220001 |
| 37 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.31460822 |
| 38 | Long-term depression_Homo sapiens_hsa04730 | 1.31355584 |
| 39 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.31350615 |
| 40 | Melanogenesis_Homo sapiens_hsa04916 | 1.29801284 |
| 41 | Gap junction_Homo sapiens_hsa04540 | 1.29152767 |
| 42 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.28502771 |
| 43 | RNA polymerase_Homo sapiens_hsa03020 | 1.26300999 |
| 44 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.17752332 |
| 45 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.16701560 |
| 46 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.15469934 |
| 47 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.14098305 |
| 48 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.10227919 |
| 49 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.05908765 |
| 50 | Protein export_Homo sapiens_hsa03060 | 1.03640637 |
| 51 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.02018870 |
| 52 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.00601451 |
| 53 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.00587427 |
| 54 | Glioma_Homo sapiens_hsa05214 | 0.97463302 |
| 55 | Basal transcription factors_Homo sapiens_hsa03022 | 0.93804641 |
| 56 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.93722896 |
| 57 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.90892262 |
| 58 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.90559490 |
| 59 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.90084368 |
| 60 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.88428806 |
| 61 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.86675382 |
| 62 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.85949524 |
| 63 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.85890617 |
| 64 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.83970505 |
| 65 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.83864995 |
| 66 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.82324631 |
| 67 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.81752252 |
| 68 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.80339921 |
| 69 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.77843157 |
| 70 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.77815173 |
| 71 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.77349892 |
| 72 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.75555672 |
| 73 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.73770434 |
| 74 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.71863952 |
| 75 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.71742549 |
| 76 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.71177260 |
| 77 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.68904184 |
| 78 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.68873393 |
| 79 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.68714986 |
| 80 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.67072407 |
| 81 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.66150135 |
| 82 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.65886812 |
| 83 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.65691022 |
| 84 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.65594771 |
| 85 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.65232581 |
| 86 | Bile secretion_Homo sapiens_hsa04976 | 0.64661978 |
| 87 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.64137311 |
| 88 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.63732700 |
| 89 | Sulfur relay system_Homo sapiens_hsa04122 | 0.61819163 |
| 90 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.61743307 |
| 91 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.61075252 |
| 92 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.60162344 |
| 93 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.59653631 |
| 94 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.57739947 |
| 95 | Colorectal cancer_Homo sapiens_hsa05210 | 0.56998998 |
| 96 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.55899407 |
| 97 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.55391408 |
| 98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.55326573 |
| 99 | Alcoholism_Homo sapiens_hsa05034 | 0.54422168 |
| 100 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.54310772 |
| 101 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.54179627 |
| 102 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.53999879 |
| 103 | Circadian rhythm_Homo sapiens_hsa04710 | 0.53796111 |
| 104 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.53783192 |
| 105 | Spliceosome_Homo sapiens_hsa03040 | 0.53390634 |
| 106 | Endometrial cancer_Homo sapiens_hsa05213 | 0.52021628 |
| 107 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.51854121 |
| 108 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.51552936 |
| 109 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.49943602 |
| 110 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.49549294 |
| 111 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.49224393 |
| 112 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.48751199 |
| 113 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.48238665 |
| 114 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.47600845 |
| 115 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.47389289 |
| 116 | RNA degradation_Homo sapiens_hsa03018 | 0.46952763 |
| 117 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.46782395 |
| 118 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.46600627 |
| 119 | Tight junction_Homo sapiens_hsa04530 | 0.42870752 |
| 120 | Endocytosis_Homo sapiens_hsa04144 | 0.42817454 |
| 121 | Homologous recombination_Homo sapiens_hsa03440 | 0.41584995 |
| 122 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.39748964 |
| 123 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.38570082 |
| 124 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.37941553 |
| 125 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.37720057 |
| 126 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.37406170 |
| 127 | Prion diseases_Homo sapiens_hsa05020 | 0.37235482 |
| 128 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.35057507 |
| 129 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.35029760 |
| 130 | Peroxisome_Homo sapiens_hsa04146 | 0.34631548 |
| 131 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.34612396 |
| 132 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.33361272 |
| 133 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.33026894 |
| 134 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.32686775 |
| 135 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.32534880 |
| 136 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.32053070 |
| 137 | Melanoma_Homo sapiens_hsa05218 | 0.30531314 |

