TMEM201

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.00795066
2mitotic chromosome condensation (GO:0007076)5.12594021
3DNA unwinding involved in DNA replication (GO:0006268)4.91021375
4cardiac myofibril assembly (GO:0055003)4.83535705
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.62457244
6cell communication by electrical coupling (GO:0010644)4.57002476
7sarcomere organization (GO:0045214)4.35338316
8negative regulation of potassium ion transmembrane transport (GO:1901380)4.32830948
9regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.24335649
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.17649716
11cardiac muscle contraction (GO:0060048)4.08600076
12DNA strand elongation involved in DNA replication (GO:0006271)4.05329993
13myofibril assembly (GO:0030239)4.00832530
14DNA strand elongation (GO:0022616)3.98946245
15DNA replication initiation (GO:0006270)3.97899963
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.90182315
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.84736420
18regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.79406971
19mitotic sister chromatid segregation (GO:0000070)3.78391858
20regulation of translational fidelity (GO:0006450)3.72480634
21heterochromatin organization (GO:0070828)3.71209930
22cardiac muscle cell development (GO:0055013)3.63263997
23negative regulation of cytosolic calcium ion concentration (GO:0051481)3.62351267
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.60501064
25regulation of membrane repolarization (GO:0060306)3.60215962
26telomere maintenance via semi-conservative replication (GO:0032201)3.57731584
27histone arginine methylation (GO:0034969)3.56136406
28protein localization to chromosome, centromeric region (GO:0071459)3.56031954
29cell communication involved in cardiac conduction (GO:0086065)3.54090089
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.52976510
31ventricular cardiac muscle cell action potential (GO:0086005)3.51894569
32adult heart development (GO:0007512)3.50170471
33cardiac cell development (GO:0055006)3.48407209
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.47850904
35protein complex localization (GO:0031503)3.45169332
36plasma membrane repair (GO:0001778)3.44678010
37sister chromatid segregation (GO:0000819)3.43766677
38nuclear pore complex assembly (GO:0051292)3.42800672
39peptidyl-arginine N-methylation (GO:0035246)3.41553178
40peptidyl-arginine methylation (GO:0018216)3.41553178
41proline biosynthetic process (GO:0006561)3.40974534
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40516786
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40373168
44positive regulation of synapse maturation (GO:0090129)3.40309671
45formation of translation preinitiation complex (GO:0001731)3.29807417
46sodium ion export (GO:0071436)3.29531552
47spliceosomal tri-snRNP complex assembly (GO:0000244)3.29396172
48regulation of short-term neuronal synaptic plasticity (GO:0048172)3.27794980
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25200163
50positive regulation of potassium ion transmembrane transport (GO:1901381)3.21015267
51DNA replication checkpoint (GO:0000076)3.20595556
52locomotory exploration behavior (GO:0035641)3.19767636
53striated muscle contraction (GO:0006941)3.16848374
54cellular protein complex localization (GO:0034629)3.15415427
55chromatin assembly (GO:0031497)3.15234771
56growth hormone secretion (GO:0030252)3.11846441
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11667765
58protein localization to kinetochore (GO:0034501)3.09669797
59synaptic vesicle maturation (GO:0016188)3.08913815
60mitotic metaphase plate congression (GO:0007080)3.08798811
61nuclear pore organization (GO:0006999)3.06520934
62rRNA transcription (GO:0009303)3.05296389
63regulation of actin filament-based movement (GO:1903115)3.03853472
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03694563
65actomyosin structure organization (GO:0031032)3.02025019
66chromosome condensation (GO:0030261)3.02001000
67protein-DNA complex disassembly (GO:0032986)3.01423366
68nucleosome disassembly (GO:0006337)3.01423366
69regulation of synapse structural plasticity (GO:0051823)3.01388800
70pre-miRNA processing (GO:0031054)3.00853805
71positive regulation of DNA-dependent DNA replication (GO:2000105)3.00363091
72cardiac muscle cell action potential involved in contraction (GO:0086002)2.98124489
73mitotic G1 DNA damage checkpoint (GO:0031571)2.96646074
74cardiac muscle cell action potential (GO:0086001)2.95816291
75cardiac muscle hypertrophy (GO:0003300)2.93823592
76regulation of NFAT protein import into nucleus (GO:0051532)2.92974153
77ribosomal small subunit biogenesis (GO:0042274)2.92558101
78mitotic nuclear envelope disassembly (GO:0007077)2.92288440
79glucocorticoid receptor signaling pathway (GO:0042921)2.91289763
80paraxial mesoderm development (GO:0048339)2.90258804
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87605692
82regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.87529871
83apoptotic process involved in morphogenesis (GO:0060561)2.87069592
84regulation of mitotic spindle organization (GO:0060236)2.87042729
85muscle filament sliding (GO:0030049)2.86716203
86actin-myosin filament sliding (GO:0033275)2.86716203
87mitochondrial fusion (GO:0008053)2.86299355
88regulation of spindle organization (GO:0090224)2.86114816
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85865468
90adherens junction assembly (GO:0034333)2.85305652
91dendritic spine morphogenesis (GO:0060997)2.85106867
92positive regulation of chromosome segregation (GO:0051984)2.84171023
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.83855075
94regulation of chromatin binding (GO:0035561)2.79610983
95cell-substrate adherens junction assembly (GO:0007045)2.78028487
96focal adhesion assembly (GO:0048041)2.78028487
97nuclear envelope disassembly (GO:0051081)2.77891636
98membrane disassembly (GO:0030397)2.77891636
99convergent extension (GO:0060026)2.77437829
100striated muscle hypertrophy (GO:0014897)2.77288804
101potassium ion export (GO:0071435)2.77110395
102negative regulation of mRNA processing (GO:0050686)2.77101211
103DNA topological change (GO:0006265)2.76701370
104cerebellar granule cell differentiation (GO:0021707)2.75979722
105sarcoplasmic reticulum calcium ion transport (GO:0070296)2.75688417
106telomere maintenance via recombination (GO:0000722)2.74676080
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.74602618
108vocalization behavior (GO:0071625)2.74452890
109mitotic sister chromatid cohesion (GO:0007064)2.74408699
110nuclear envelope reassembly (GO:0031468)2.73771796
111mitotic nuclear envelope reassembly (GO:0007084)2.73771796
112G1 DNA damage checkpoint (GO:0044783)2.72477203
113regulation of synapse maturation (GO:0090128)2.72378563
114DNA synthesis involved in DNA repair (GO:0000731)2.70852439
115protein retention in ER lumen (GO:0006621)2.70093502
116DNA duplex unwinding (GO:0032508)2.69921988
117striatum development (GO:0021756)2.68050676
118cerebellar Purkinje cell differentiation (GO:0021702)2.67837635
119RNA stabilization (GO:0043489)2.67263848
120mRNA stabilization (GO:0048255)2.67263848
121mitotic G1/S transition checkpoint (GO:0044819)2.66198664
122cardiac muscle tissue morphogenesis (GO:0055008)2.65544097
123positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.65497837
124snRNA metabolic process (GO:0016073)2.62510456
125negative regulation of potassium ion transport (GO:0043267)2.62372689
126negative regulation of mRNA metabolic process (GO:1903312)2.62168165
127folic acid metabolic process (GO:0046655)2.61720470
128positive regulation of sodium ion transport (GO:0010765)2.61195421
129maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61000451
130ribosome biogenesis (GO:0042254)2.60634206
131negative regulation of cell size (GO:0045792)2.60080912
132peptidyl-lysine dimethylation (GO:0018027)2.59114378
133regulation of cell communication by electrical coupling (GO:0010649)2.59070888
134cellular potassium ion homeostasis (GO:0030007)2.58953360
135DNA packaging (GO:0006323)2.58488809
136layer formation in cerebral cortex (GO:0021819)2.58204667
137regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58065577
138ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.56904747
139membrane depolarization during action potential (GO:0086010)2.56522413
140regulation of RNA export from nucleus (GO:0046831)2.56509049
141maturation of SSU-rRNA (GO:0030490)2.56313199
142pore complex assembly (GO:0046931)2.56246886
143regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54976078
144regulation of the force of heart contraction (GO:0002026)2.54293469
145nuclear envelope organization (GO:0006998)2.53970809
146negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.53863785
147heart trabecula formation (GO:0060347)2.53727325
148mitotic recombination (GO:0006312)2.52903877
149ventricular cardiac muscle cell development (GO:0055015)2.52884517
150DNA conformation change (GO:0071103)2.52847336
151base-excision repair (GO:0006284)2.51168121
152COPI coating of Golgi vesicle (GO:0048205)2.50465624
153Golgi transport vesicle coating (GO:0048200)2.50465624
154positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.49932437
155DNA geometric change (GO:0032392)2.49570907
156chromatin assembly or disassembly (GO:0006333)2.47200498
157regulation of striated muscle contraction (GO:0006942)2.47045635
158negative regulation of histone methylation (GO:0031061)2.46359385
159establishment of integrated proviral latency (GO:0075713)2.46271555
160nucleotide-excision repair, DNA gap filling (GO:0006297)2.46262383
161* establishment of nucleus localization (GO:0040023)2.45906464
162positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.45774888
1633-UTR-mediated mRNA stabilization (GO:0070935)2.44844025
164deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.44705512
165protein maturation by protein folding (GO:0022417)2.44433078
166regulation of glutamate receptor signaling pathway (GO:1900449)2.44421120
167regulation of calcium ion transmembrane transporter activity (GO:1901019)2.44092470
168regulation of calcium ion transmembrane transport (GO:1903169)2.44092470
169ribonucleoprotein complex biogenesis (GO:0022613)2.43614572
170IMP metabolic process (GO:0046040)2.43052551
171venous blood vessel morphogenesis (GO:0048845)2.42676437
172cardiac conduction (GO:0061337)2.41702486
173cell migration in hindbrain (GO:0021535)2.40803827
174long-term memory (GO:0007616)2.40187110
175auditory behavior (GO:0031223)2.39777123
176peptidyl-arginine omega-N-methylation (GO:0035247)2.38372226
177muscle cell fate commitment (GO:0042693)2.38087333
178histone H4-K8 acetylation (GO:0043982)2.38053900
179histone H4-K5 acetylation (GO:0043981)2.38053900
180synaptic transmission, glutamatergic (GO:0035249)2.36310870
181regulation of long-term neuronal synaptic plasticity (GO:0048169)2.35752151
182nucleobase-containing small molecule interconversion (GO:0015949)2.35091656
183negative regulation of RNA splicing (GO:0033119)2.34651190
184neuronal action potential propagation (GO:0019227)2.34407312
185regulation of relaxation of muscle (GO:1901077)2.34236996
186regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33876517
187regulation of heart rate by cardiac conduction (GO:0086091)2.33315237
188* nucleus localization (GO:0051647)2.33218816
189intracellular estrogen receptor signaling pathway (GO:0030520)2.33197029
190G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32882890
191neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.32837912
192tricarboxylic acid cycle (GO:0006099)2.32775849
193dosage compensation (GO:0007549)2.32692911
194cell differentiation in hindbrain (GO:0021533)2.32468487
195muscle tissue morphogenesis (GO:0060415)2.31987565
196primitive streak formation (GO:0090009)2.30232965
197neuromuscular process controlling balance (GO:0050885)2.28102605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.97081483
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.21117478
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.14301762
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08475705
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07647373
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95222598
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.62972371
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62094543
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37658897
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36767002
11RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.33109130
12E2F7_22180533_ChIP-Seq_HELA_Human2.33100151
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.31149723
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30786112
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.28892210
16DROSHA_22980978_ChIP-Seq_HELA_Human2.27199690
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26673265
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20740208
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20467908
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19510257
21VDR_21846776_ChIP-Seq_THP-1_Human2.16436277
22CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.14444951
23XRN2_22483619_ChIP-Seq_HELA_Human2.13990715
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.12715758
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11963273
26* RARB_27405468_Chip-Seq_BRAIN_Mouse2.03159774
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.02787226
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99613921
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.98380636
30ZFP281_27345836_Chip-Seq_ESCs_Mouse1.86903880
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86880378
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80835324
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80835324
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79614016
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79481898
36REST_21632747_ChIP-Seq_MESCs_Mouse1.77443686
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.76836685
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75995483
39* KDM2B_26808549_Chip-Seq_K562_Human1.75766562
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74421554
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.70644703
42MYC_22102868_ChIP-Seq_BL_Human1.70003730
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69522710
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.69392944
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.64477357
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.61745848
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61134621
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.60637144
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.60418462
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.58135576
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.56513997
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.53709346
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52851931
54RACK7_27058665_Chip-Seq_MCF-7_Human1.52605980
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52403802
56* KDM2B_26808549_Chip-Seq_DND41_Human1.51780204
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50268736
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50044112
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49190779
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48873313
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48814045
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47230207
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46961256
64TTF2_22483619_ChIP-Seq_HELA_Human1.46823070
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46704071
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46221826
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45760148
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45669885
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.42954851
70DCP1A_22483619_ChIP-Seq_HELA_Human1.42845800
71* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42094115
72CIITA_25753668_ChIP-Seq_RAJI_Human1.40824200
73GABP_19822575_ChIP-Seq_HepG2_Human1.40478735
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39794240
75* CTCF_27219007_Chip-Seq_Bcells_Human1.39638133
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37870652
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37395211
78KDM5A_27292631_Chip-Seq_BREAST_Human1.37081963
79ZNF263_19887448_ChIP-Seq_K562_Human1.36063796
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33521066
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32414914
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31013733
83P68_20966046_ChIP-Seq_HELA_Human1.30798528
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.30616896
85* SMC4_20622854_ChIP-Seq_HELA_Human1.29741029
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29503771
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28505940
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.28117721
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27136916
90AR_21909140_ChIP-Seq_LNCAP_Human1.26828296
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26323827
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24844700
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23620545
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22154915
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22018911
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21739149
97LXR_22292898_ChIP-Seq_THP-1_Human1.21220898
98* KDM2B_26808549_Chip-Seq_JURKAT_Human1.20304921
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.20212884
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.19029864
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18853651
102* SA1_27219007_Chip-Seq_ERYTHROID_Human1.18448665
103TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17976345
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17246141
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.16953606
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16217525
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15982341
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15825912
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15791025
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15713427
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15535669
112POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15470397
113IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15284417
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14942743
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14940952
116* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14315418
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13733479
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13185331
119EP300_21415370_ChIP-Seq_HL-1_Mouse1.12874602
120THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12688761
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12642359
122* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12149922
123TP53_20018659_ChIP-ChIP_R1E_Mouse1.12063411
124* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11823089
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11759306
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10553564
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10520179
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10167049
129SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09946243
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08508858
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08392164
132* OCT4_19829295_ChIP-Seq_ESCs_Human1.08165042
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07405683
134AR_19668381_ChIP-Seq_PC3_Human1.07324221
135STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07184929
136RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07063262
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06913890
138* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06446078
139* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06235644
140TP63_17297297_ChIP-ChIP_HaCaT_Human1.05758726
141ISL1_27105846_Chip-Seq_CPCs_Mouse1.05467815
142* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03800488
143* FOXP1_21924763_ChIP-Seq_HESCs_Human1.03610868
144TP53_23651856_ChIP-Seq_MEFs_Mouse1.03352431
145EED_16625203_ChIP-ChIP_MESCs_Mouse1.02181272
146NANOG_21062744_ChIP-ChIP_HESCs_Human1.02175120
147TCF7_22412390_ChIP-Seq_EML_Mouse1.01804844
148HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01754813
149* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01372430
150SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01160618
151* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00322534
152EGR1_19374776_ChIP-ChIP_THP-1_Human1.00280726
153MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00056890
154KLF4_19829295_ChIP-Seq_ESCs_Human0.99985059
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99469692
156SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98900232
157CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98842592
158ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97401130
159TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97087993
160NCOR1_26117541_ChIP-Seq_K562_Human0.96558581
161KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96277506
162* CREB1_26743006_Chip-Seq_LNCaP_Human0.96202462
163RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95860869
164TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95466469
165ZNF274_21170338_ChIP-Seq_K562_Hela0.95267666
166CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95209725
167MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95138953
168SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94346725
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93904193
170CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92133940
171NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91763641
172WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90733018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.35825160
2MP0000751_myopathy3.36207231
3MP0004084_abnormal_cardiac_muscle3.29915331
4MP0004859_abnormal_synaptic_plasticity3.27242620
5MP0002837_dystrophic_cardiac_calcinosis3.26553830
6MP0003693_abnormal_embryo_hatching3.00508468
7MP0004215_abnormal_myocardial_fiber2.94165153
8MP0004145_abnormal_muscle_electrophysio2.85956055
9MP0003705_abnormal_hypodermis_morpholog2.50433208
10MP0003137_abnormal_impulse_conducting2.45902808
11MP0002234_abnormal_pharynx_morphology2.40677152
12MP0008932_abnormal_embryonic_tissue2.34271096
13MP0005451_abnormal_body_composition2.33993482
14MP0003122_maternal_imprinting2.27087719
15MP0000749_muscle_degeneration2.26840635
16MP0004957_abnormal_blastocyst_morpholog2.26412848
17MP0004036_abnormal_muscle_relaxation2.23351597
18MP0006292_abnormal_olfactory_placode2.22272614
19MP0008057_abnormal_DNA_replication2.06087644
20MP0001730_embryonic_growth_arrest2.04528174
21MP0005330_cardiomyopathy2.03637743
22MP0005076_abnormal_cell_differentiation1.93657816
23MP0000733_abnormal_muscle_development1.91308561
24MP0005623_abnormal_meninges_morphology1.90456315
25MP0003283_abnormal_digestive_organ1.89447680
26MP0004087_abnormal_muscle_fiber1.85794367
27MP0003635_abnormal_synaptic_transmissio1.85740791
28MP0002877_abnormal_melanocyte_morpholog1.83069960
29MP0002106_abnormal_muscle_physiology1.80901654
30MP0004233_abnormal_muscle_weight1.76726580
31MP0004185_abnormal_adipocyte_glucose1.75105948
32MP0001346_abnormal_lacrimal_gland1.69891678
33MP0000350_abnormal_cell_proliferation1.69436820
34MP0002269_muscular_atrophy1.66959431
35MP0009672_abnormal_birth_weight1.65000013
36MP0003121_genomic_imprinting1.59864786
37MP0004085_abnormal_heartbeat1.59853860
38MP0008007_abnormal_cellular_replicative1.58860725
39MP0002653_abnormal_ependyma_morphology1.58583128
40MP0000537_abnormal_urethra_morphology1.58560397
41MP0009046_muscle_twitch1.56473447
42MP0010630_abnormal_cardiac_muscle1.56398477
43MP0005620_abnormal_muscle_contractility1.54218888
44MP0008961_abnormal_basal_metabolism1.53435912
45MP0000750_abnormal_muscle_regeneration1.51959572
46MP0005423_abnormal_somatic_nervous1.51692140
47MP0002972_abnormal_cardiac_muscle1.51115956
48MP0006138_congestive_heart_failure1.49644603
49MP0008775_abnormal_heart_ventricle1.49476979
50MP0000678_abnormal_parathyroid_gland1.45685212
51MP0005369_muscle_phenotype1.45455545
52MP0002102_abnormal_ear_morphology1.45112821
53MP0001661_extended_life_span1.43162690
54MP0004484_altered_response_of1.42865463
55MP0008058_abnormal_DNA_repair1.41466474
56MP0002080_prenatal_lethality1.40988664
57MP0003111_abnormal_nucleus_morphology1.40625433
58MP0000759_abnormal_skeletal_muscle1.40154585
59MP0002127_abnormal_cardiovascular_syste1.39150577
60MP0010030_abnormal_orbit_morphology1.37529272
61MP0000747_muscle_weakness1.37243257
62MP0002063_abnormal_learning/memory/cond1.36550444
63MP0001849_ear_inflammation1.33922234
64MP0001697_abnormal_embryo_size1.33226221
65MP0008995_early_reproductive_senescence1.32870350
66MP0001544_abnormal_cardiovascular_syste1.32121962
67MP0005385_cardiovascular_system_phenoty1.32121962
68MP0000003_abnormal_adipose_tissue1.27099941
69MP0004858_abnormal_nervous_system1.26289605
70MP0005409_darkened_coat_color1.24558982
71MP0004270_analgesia1.24502030
72MP0008569_lethality_at_weaning1.24009989
73MP0009745_abnormal_behavioral_response1.23144752
74MP0003942_abnormal_urinary_system1.19799426
75MP0000049_abnormal_middle_ear1.19758342
76MP0002697_abnormal_eye_size1.19164985
77MP0003567_abnormal_fetal_cardiomyocyte1.18317389
78MP0003119_abnormal_digestive_system1.16712029
79MP0002184_abnormal_innervation1.16593177
80MP0003880_abnormal_central_pattern1.16423817
81MP0002064_seizures1.14472076
82MP0001486_abnormal_startle_reflex1.13777325
83MP0001348_abnormal_lacrimal_gland1.12978671
84MP0002089_abnormal_postnatal_growth/wei1.12839314
85MP0003385_abnormal_body_wall1.07206413
86MP0004197_abnormal_fetal_growth/weight/1.06857690
87MP0000313_abnormal_cell_death1.06768551
88MP0002572_abnormal_emotion/affect_behav1.06576782
89MP0010094_abnormal_chromosome_stability1.06334383
90MP0002272_abnormal_nervous_system1.06323658
91MP0002114_abnormal_axial_skeleton1.03524536
92MP0003786_premature_aging1.03499513
93MP0002396_abnormal_hematopoietic_system1.03215772
94MP0003315_abnormal_perineum_morphology1.02005282
95MP0004133_heterotaxia1.01125885
96MP0004808_abnormal_hematopoietic_stem1.00848788
97MP0000778_abnormal_nervous_system0.99783131
98MP0004130_abnormal_muscle_cell0.98566498
99MP0004924_abnormal_behavior0.97493849
100MP0005386_behavior/neurological_phenoty0.97493849
101MP0000579_abnormal_nail_morphology0.96906387
102MP0003123_paternal_imprinting0.96864206
103MP0005257_abnormal_intraocular_pressure0.96589637
104MP0008260_abnormal_autophagy0.96415377
105MP0009278_abnormal_bone_marrow0.95805647
106MP0005501_abnormal_skin_physiology0.95140343
107MP0006035_abnormal_mitochondrial_morpho0.94728826
108MP0005187_abnormal_penis_morphology0.94697785
109MP0002086_abnormal_extraembryonic_tissu0.94604492
110MP0002067_abnormal_sensory_capabilities0.94539544
111MP0005380_embryogenesis_phenotype0.94193129
112MP0001672_abnormal_embryogenesis/_devel0.94193129
113MP0002249_abnormal_larynx_morphology0.92870235
114MP0003890_abnormal_embryonic-extraembry0.92217623
115MP0000762_abnormal_tongue_morphology0.90697689
116MP0002734_abnormal_mechanical_nocicepti0.89573560
117MP0003861_abnormal_nervous_system0.89446435
118MP0000534_abnormal_ureter_morphology0.89067565
119MP0005171_absent_coat_pigmentation0.89049341
120MP0000266_abnormal_heart_morphology0.88431799
121MP0003984_embryonic_growth_retardation0.88384248
122MP0001529_abnormal_vocalization0.88223047
123MP0000955_abnormal_spinal_cord0.88104524
124MP0002088_abnormal_embryonic_growth/wei0.86736085
125MP0005670_abnormal_white_adipose0.86208606
126MP0009379_abnormal_foot_pigmentation0.85446230
127MP0002111_abnormal_tail_morphology0.85410623
128MP0002084_abnormal_developmental_patter0.85109887
129MP0001984_abnormal_olfaction0.85082930
130MP0002085_abnormal_embryonic_tissue0.84509709
131MP0003077_abnormal_cell_cycle0.84360079
132MP0001968_abnormal_touch/_nociception0.84179725
133MP0003115_abnormal_respiratory_system0.83596067
134MP0002557_abnormal_social/conspecific_i0.82960421
135MP0002116_abnormal_craniofacial_bone0.82792160
136MP0002152_abnormal_brain_morphology0.82503259
137MP0005621_abnormal_cell_physiology0.80971134
138MP0002822_catalepsy0.80919152
139MP0002092_abnormal_eye_morphology0.80465961
140MP0003828_pulmonary_edema0.80336315
141MP0006036_abnormal_mitochondrial_physio0.80052437
142MP0005394_taste/olfaction_phenotype0.79919280
143MP0005499_abnormal_olfactory_system0.79919280
144MP0006072_abnormal_retinal_apoptosis0.79816052
145MP0001293_anophthalmia0.79545160
146MP0003566_abnormal_cell_adhesion0.79019183
147MP0002332_abnormal_exercise_endurance0.78867915
148MP0005375_adipose_tissue_phenotype0.78633185
149MP0002081_perinatal_lethality0.78334462
150MP0000566_synostosis0.77972353
151MP0005666_abnormal_adipose_tissue0.77898471
152MP0010352_gastrointestinal_tract_polyps0.76970317
153MP0004811_abnormal_neuron_physiology0.76159959
154MP0002882_abnormal_neuron_morphology0.75900562
155MP0005645_abnormal_hypothalamus_physiol0.75797158
156MP0005384_cellular_phenotype0.75739540
157MP0001440_abnormal_grooming_behavior0.75630437
158MP0003221_abnormal_cardiomyocyte_apopto0.75430098
159MP0002108_abnormal_muscle_morphology0.74695946
160MP0001502_abnormal_circadian_rhythm0.74603973
161MP0003935_abnormal_craniofacial_develop0.73477922
162MP0008877_abnormal_DNA_methylation0.73218784
163MP0000428_abnormal_craniofacial_morphol0.72635818
164MP0000358_abnormal_cell_content/0.72604488

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.97365449
2Bundle branch block (HP:0011710)4.40065149
3Atrial fibrillation (HP:0005110)4.38544690
4Primary atrial arrhythmia (HP:0001692)4.26341613
5Supraventricular tachycardia (HP:0004755)4.15908110
6Ventricular fibrillation (HP:0001663)4.11476050
7Supraventricular arrhythmia (HP:0005115)4.04451707
8Ventricular tachycardia (HP:0004756)3.72665049
9Exercise-induced myalgia (HP:0003738)3.71889304
10Abnormality of the left ventricular outflow tract (HP:0011103)3.62772649
11Subaortic stenosis (HP:0001682)3.62772649
12Atrioventricular block (HP:0001678)3.50897854
13Calf muscle hypertrophy (HP:0008981)3.44806341
14Heart block (HP:0012722)3.41661938
15Progressive muscle weakness (HP:0003323)3.41214582
16Prolonged QT interval (HP:0001657)3.38781328
17Syncope (HP:0001279)3.31126769
18Myopathic facies (HP:0002058)3.25054517
19Muscle fiber inclusion bodies (HP:0100299)3.19969504
20Exercise-induced muscle cramps (HP:0003710)3.15924226
21Abnormal EKG (HP:0003115)3.13265150
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.12576903
23Abnormal atrioventricular conduction (HP:0005150)3.09024708
24Muscle hypertrophy of the lower extremities (HP:0008968)3.06952768
25Ventricular arrhythmia (HP:0004308)3.06599078
26Abnormality of the calf musculature (HP:0001430)3.04452491
27Nemaline bodies (HP:0003798)3.03335642
28Ependymoma (HP:0002888)3.03200132
29Dysmetric saccades (HP:0000641)3.02106037
30Centrally nucleated skeletal muscle fibers (HP:0003687)3.01409224
31Difficulty running (HP:0009046)2.88371637
32Muscle fiber splitting (HP:0003555)2.86551437
33Focal motor seizures (HP:0011153)2.81368887
34Abnormality of the lower motor neuron (HP:0002366)2.79856670
35Truncus arteriosus (HP:0001660)2.74029267
36Ulnar bowing (HP:0003031)2.73813019
37Hyperacusis (HP:0010780)2.71588800
38Ragged-red muscle fibers (HP:0003200)2.69676340
39Type 1 muscle fiber predominance (HP:0003803)2.67475408
40Trismus (HP:0000211)2.66618605
41Distal lower limb amyotrophy (HP:0008944)2.66050877
42Myokymia (HP:0002411)2.64928697
43Myotonia (HP:0002486)2.62838032
44Renal duplication (HP:0000075)2.59576579
45High anterior hairline (HP:0009890)2.58646343
46Lipoatrophy (HP:0100578)2.55947441
47Calcaneovalgus deformity (HP:0001848)2.52586884
48Difficulty climbing stairs (HP:0003551)2.45705254
49Visual hallucinations (HP:0002367)2.45462750
50Microvesicular hepatic steatosis (HP:0001414)2.44752701
51Elfin facies (HP:0004428)2.40840184
52Achilles tendon contracture (HP:0001771)2.38252401
53Focal seizures (HP:0007359)2.38054678
54Abnormality of skeletal muscle fiber size (HP:0012084)2.37021157
55Abnormality of the calcaneus (HP:0008364)2.36142050
56Astrocytoma (HP:0009592)2.34664876
57Abnormality of the astrocytes (HP:0100707)2.34664876
58Broad distal phalanx of finger (HP:0009836)2.33247736
59Selective tooth agenesis (HP:0001592)2.29602890
60Myoglobinuria (HP:0002913)2.29456498
61Annular pancreas (HP:0001734)2.27636845
62Pointed chin (HP:0000307)2.26940406
63Increased variability in muscle fiber diameter (HP:0003557)2.24077835
64Hyperthyroidism (HP:0000836)2.21777851
65Dilated cardiomyopathy (HP:0001644)2.19201912
66Left ventricular hypertrophy (HP:0001712)2.13600118
67Bilateral microphthalmos (HP:0007633)2.13267092
68Cholecystitis (HP:0001082)2.13085785
69Abnormal gallbladder physiology (HP:0012438)2.13085785
70Proximal placement of thumb (HP:0009623)2.12612203
71Insomnia (HP:0100785)2.11004372
72Long palpebral fissure (HP:0000637)2.07611456
73EMG: myopathic abnormalities (HP:0003458)2.06479653
74Deformed tarsal bones (HP:0008119)2.05786611
75Lower limb amyotrophy (HP:0007210)2.04513491
76Central scotoma (HP:0000603)2.04465408
77Increased connective tissue (HP:0009025)2.02930589
78Abnormality of the labia minora (HP:0012880)2.02299498
79Abnormality of chromosome segregation (HP:0002916)2.02173290
80Febrile seizures (HP:0002373)2.01847303
81Spinal rigidity (HP:0003306)2.01726215
82Deviation of the thumb (HP:0009603)2.01404168
83Hyporeflexia of lower limbs (HP:0002600)2.00026801
84Pendular nystagmus (HP:0012043)1.99618460
85Flat cornea (HP:0007720)1.99282108
86Distal lower limb muscle weakness (HP:0009053)1.98151595
87Muscle stiffness (HP:0003552)1.97940073
88Progressive cerebellar ataxia (HP:0002073)1.96701010
89Abnormality of the tricuspid valve (HP:0001702)1.94928484
90Bowel incontinence (HP:0002607)1.94436969
91Turricephaly (HP:0000262)1.93733980
92Urethral obstruction (HP:0000796)1.93235506
93Generalized amyotrophy (HP:0003700)1.92795508
94Self-mutilation (HP:0000742)1.92313375
95Glioma (HP:0009733)1.92145232
96Abnormality of the Achilles tendon (HP:0005109)1.90680073
97Broad-based gait (HP:0002136)1.89165095
98Metatarsus adductus (HP:0001840)1.89022533
99Septate vagina (HP:0001153)1.88147654
100Overriding aorta (HP:0002623)1.87978058
101Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87556546
102Failure to thrive in infancy (HP:0001531)1.87418985
103Chromsome breakage (HP:0040012)1.87345638
104Stridor (HP:0010307)1.86124581
105Disproportionate tall stature (HP:0001519)1.85644884
106Round ear (HP:0100830)1.85446397
107Upper limb amyotrophy (HP:0009129)1.85386607
108Distal upper limb amyotrophy (HP:0007149)1.85386607
109Abnormal large intestine physiology (HP:0012700)1.85236030
110Neoplasm of the oral cavity (HP:0100649)1.84137835
111Mildly elevated creatine phosphokinase (HP:0008180)1.83790106
112Asymmetric septal hypertrophy (HP:0001670)1.83687898
113Action tremor (HP:0002345)1.83250517
114EMG: neuropathic changes (HP:0003445)1.82625252
115Genetic anticipation (HP:0003743)1.81883445
116Shallow orbits (HP:0000586)1.81541485
117Patellar dislocation (HP:0002999)1.81079924
118Renovascular hypertension (HP:0100817)1.80848685
119Progressive external ophthalmoplegia (HP:0000590)1.80377921
120Reticulocytopenia (HP:0001896)1.79749016
121Abnormality of the umbilical cord (HP:0010881)1.78226202
122Hyperalaninemia (HP:0003348)1.77497031
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77497031
124Abnormality of alanine metabolism (HP:0010916)1.77497031
125Maternal diabetes (HP:0009800)1.76980075
126Neoplasm of the heart (HP:0100544)1.75869250
127Palpitations (HP:0001962)1.75069051
128Breech presentation (HP:0001623)1.74861494
129Multiple enchondromatosis (HP:0005701)1.74312182
130Horizontal nystagmus (HP:0000666)1.73188764
131Abnormality of reticulocytes (HP:0004312)1.72536126
132Abnormal number of incisors (HP:0011064)1.71761608
133Abnormality of the phalanges of the hallux (HP:0010057)1.70184977
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69773418
135Reticulocytosis (HP:0001923)1.69119493
136Poor eye contact (HP:0000817)1.69095831
137Abnormality of the aortic arch (HP:0012303)1.69063959
138Preauricular skin tag (HP:0000384)1.68680839
139Limb-girdle muscle atrophy (HP:0003797)1.67903234
140Unsteady gait (HP:0002317)1.67321786
141Short palpebral fissure (HP:0012745)1.67315188
142Duplication of thumb phalanx (HP:0009942)1.67202407
143Scotoma (HP:0000575)1.66568861
144Patellar aplasia (HP:0006443)1.65837556
145Tented upper lip vermilion (HP:0010804)1.65149524
146Atresia of the external auditory canal (HP:0000413)1.64582115
147Dysdiadochokinesis (HP:0002075)1.64407659
148Abnormality of the pubic bones (HP:0003172)1.64162734
149Hypokinesia (HP:0002375)1.63316381
150Trigonocephaly (HP:0000243)1.63069353
151Fetal akinesia sequence (HP:0001989)1.62829249
152Gaze-evoked nystagmus (HP:0000640)1.61304217
153Abnormality of cochlea (HP:0000375)1.60849443
154Broad face (HP:0000283)1.60806762
155Thin ribs (HP:0000883)1.60634069
156Adducted thumb (HP:0001181)1.59998627
157Breast hypoplasia (HP:0003187)1.59694530
158Ulnar deviation of the wrist (HP:0003049)1.59425915
159Medulloblastoma (HP:0002885)1.58491953
160Long eyelashes (HP:0000527)1.58173579
161Hemiplegia (HP:0002301)1.57960720
162Congenital hip dislocation (HP:0001374)1.57839720
163Squamous cell carcinoma (HP:0002860)1.57375569
164Abnormal social behavior (HP:0012433)1.57346588
165Impaired social interactions (HP:0000735)1.57346588
166Shawl scrotum (HP:0000049)1.57239502
167Colon cancer (HP:0003003)1.56515215
168Increased nuchal translucency (HP:0010880)1.56072436
169Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55694516
170Narrow nasal bridge (HP:0000446)1.55454880
171Megalocornea (HP:0000485)1.55423236
172Shoulder girdle muscle weakness (HP:0003547)1.55214771
173Anosmia (HP:0000458)1.53738940
174Depression (HP:0000716)1.53067439
175Unilateral renal agenesis (HP:0000122)1.52894471
176Chromosomal breakage induced by crosslinking agents (HP:0003221)1.52873476
177Distal arthrogryposis (HP:0005684)1.52735600
178Back pain (HP:0003418)1.52565637
179Abnormality of the salivary glands (HP:0010286)1.52353239
180Obstructive sleep apnea (HP:0002870)1.51915232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.44285296
2MUSK2.85840679
3CDK122.69206660
4PHKG22.51238877
5PHKG12.51238877
6KSR12.33237893
7SIK12.20984803
8NEK12.20884436
9NME22.17843428
10VRK22.13687050
11PINK12.06754760
12LATS22.03225944
13PAK62.00599439
14MAP3K61.96064126
15TTN1.93597278
16IRAK31.92999389
17MAP2K41.90859999
18LMTK21.84919902
19DMPK1.83790942
20NTRK31.83683906
21MAP3K91.80206109
22STK381.80008764
23NTRK21.59317028
24MAP2K61.53598756
25PRKD31.52125666
26PKN21.50643691
27TRIB31.50414386
28SIK31.49995462
29OBSCN1.46155350
30MINK11.45396726
31EEF2K1.44174513
32MARK11.42997981
33RIPK11.41792930
34EPHB21.34826056
35CAMK11.33315566
36AURKA1.33203552
37CDC71.33099688
38TYRO31.32246942
39ICK1.29438206
40PRPF4B1.25158426
41MAP2K31.24521518
42EPHA21.24430766
43TAOK11.23653835
44TTK1.22792583
45MAP3K41.22026230
46MARK21.20831073
47ARAF1.20062268
48TNIK1.18622530
49PIM21.17850078
50TAF11.17767831
51NEK21.14698445
52CDC42BPA1.14165902
53CDK41.05442923
54CAMK41.03615321
55EPHA41.02575778
56ALK0.99823638
57BRD40.99323961
58SIK20.98932175
59MAP3K70.97129113
60NME10.97036555
61AKT20.96696181
62MAP3K80.95998289
63BRAF0.95230196
64MAPK110.95090015
65SRPK10.90529597
66CAMKK10.90258733
67MAP3K50.89939247
68TAOK20.88187437
69PRKAA10.87182152
70PAK30.85327539
71LATS10.84794887
72CDK90.82923833
73TIE10.82390459
74MAP3K100.82020368
75UHMK10.79972547
76KSR20.79415639
77AURKB0.76943235
78RPS6KA20.73893253
79CDK70.71912019
80PDGFRA0.71506686
81CDK190.70338182
82MAP3K130.70164163
83ERBB20.69324441
84PBK0.69281718
85CAMK1G0.68809561
86PTK20.68740934
87TSSK60.68432211
88STK40.67322826
89MTOR0.65785374
90MAPK120.65710640
91PAK40.65659264
92CHEK20.65208665
93ERN10.63304900
94RPS6KC10.61855124
95RPS6KL10.61855124
96STK110.61743199
97BRSK10.61599368
98CSNK1G30.60998545
99IRAK20.58309834
100FGFR40.57294184
101CDK80.56458820
102ATR0.55775756
103MST1R0.55168115
104TESK20.55026099
105MAPK130.54918193
106PLK10.54068278
107TGFBR10.53179906
108CDK20.52955622
109NTRK10.52794916
110CAMK1D0.52585413
111CDK180.52555342
112MAP2K70.51916102
113CSNK1A1L0.50972184
114SGK20.50540613
115CHEK10.50537630
116BUB10.49906313
117CDK11A0.49857681
118STK38L0.49660478
119CDK150.47913790
120SCYL20.47589658
121BCKDK0.46795881
122WEE10.46622994
123MAPK100.45541073
124RPS6KA30.45510341
125SGK30.45277130
126RPS6KA10.45081288
127CCNB10.44758221
128PAK10.44342030
129MAP3K110.44096323
130RPS6KA60.44007278
131PAK20.43331771
132RAF10.43305180
133CDK50.42575448
134PDK30.42525014
135PDK40.42525014
136DAPK10.41859737
137PRKCI0.41639217
138GSK3B0.40789290
139MELK0.39215427
140KDR0.39148575
141PRKD10.39000416
142CDK10.38952464
143CDK140.37717520
144CSNK1G10.37276499
145SGK10.37265749
146RPS6KB20.37240325
147CAMKK20.36564400
148MOS0.35599358

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.52281735
2Dilated cardiomyopathy_Homo sapiens_hsa054142.50517411
3Cardiac muscle contraction_Homo sapiens_hsa042602.49261341
4Sulfur relay system_Homo sapiens_hsa041222.32589368
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.23305800
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17595348
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.15297110
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12118735
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.07989418
10Circadian entrainment_Homo sapiens_hsa047131.82797897
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.76077621
12Glutamatergic synapse_Homo sapiens_hsa047241.73801805
13Nucleotide excision repair_Homo sapiens_hsa034201.72425471
14Pentose phosphate pathway_Homo sapiens_hsa000301.65382983
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65097710
16Olfactory transduction_Homo sapiens_hsa047401.61215917
17Ribosome_Homo sapiens_hsa030101.55033444
18GABAergic synapse_Homo sapiens_hsa047271.54831102
19Long-term potentiation_Homo sapiens_hsa047201.53138877
20Notch signaling pathway_Homo sapiens_hsa043301.53067679
21Pyrimidine metabolism_Homo sapiens_hsa002401.51914817
22Basal cell carcinoma_Homo sapiens_hsa052171.48315639
23Bladder cancer_Homo sapiens_hsa052191.42764330
24Oxytocin signaling pathway_Homo sapiens_hsa049211.41593919
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41474630
26Circadian rhythm_Homo sapiens_hsa047101.38648383
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37698177
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37615176
29Morphine addiction_Homo sapiens_hsa050321.37384190
30Oocyte meiosis_Homo sapiens_hsa041141.37241837
31RNA polymerase_Homo sapiens_hsa030201.36757588
32Chronic myeloid leukemia_Homo sapiens_hsa052201.36061135
33Calcium signaling pathway_Homo sapiens_hsa040201.35882119
34mRNA surveillance pathway_Homo sapiens_hsa030151.34178195
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31005191
36One carbon pool by folate_Homo sapiens_hsa006701.30497455
37GnRH signaling pathway_Homo sapiens_hsa049121.27847587
38Fructose and mannose metabolism_Homo sapiens_hsa000511.27615083
39Lysine degradation_Homo sapiens_hsa003101.27287372
40Synaptic vesicle cycle_Homo sapiens_hsa047211.25478823
41Taste transduction_Homo sapiens_hsa047421.22320883
42Thyroid cancer_Homo sapiens_hsa052161.20322047
43Insulin secretion_Homo sapiens_hsa049111.19592329
44Salivary secretion_Homo sapiens_hsa049701.14954699
45Dopaminergic synapse_Homo sapiens_hsa047281.14215786
46Non-homologous end-joining_Homo sapiens_hsa034501.13509152
47Hedgehog signaling pathway_Homo sapiens_hsa043401.13398068
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12400998
49mTOR signaling pathway_Homo sapiens_hsa041501.12206161
50DNA replication_Homo sapiens_hsa030301.10944917
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10752975
52RNA transport_Homo sapiens_hsa030131.10665355
53Amphetamine addiction_Homo sapiens_hsa050311.06850429
54Cholinergic synapse_Homo sapiens_hsa047251.06075215
55cAMP signaling pathway_Homo sapiens_hsa040241.05906149
56Gastric acid secretion_Homo sapiens_hsa049711.04758639
57Base excision repair_Homo sapiens_hsa034101.03659437
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.03217124
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.02604911
60Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02186475
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00511186
62Long-term depression_Homo sapiens_hsa047301.00088473
63MicroRNAs in cancer_Homo sapiens_hsa052061.00059236
64Small cell lung cancer_Homo sapiens_hsa052220.99206693
65Gap junction_Homo sapiens_hsa045400.99161106
66Cell cycle_Homo sapiens_hsa041100.96162260
67Melanogenesis_Homo sapiens_hsa049160.95585970
68Biosynthesis of amino acids_Homo sapiens_hsa012300.95208441
69Mismatch repair_Homo sapiens_hsa034300.92667346
70Hippo signaling pathway_Homo sapiens_hsa043900.92216669
71RNA degradation_Homo sapiens_hsa030180.92120198
72Wnt signaling pathway_Homo sapiens_hsa043100.91474226
73Glucagon signaling pathway_Homo sapiens_hsa049220.90805986
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90349441
75N-Glycan biosynthesis_Homo sapiens_hsa005100.89865763
76Type II diabetes mellitus_Homo sapiens_hsa049300.87767195
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87115784
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86886077
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86267466
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86258567
81Carbon metabolism_Homo sapiens_hsa012000.85960249
82Phototransduction_Homo sapiens_hsa047440.84562095
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84451175
84Insulin signaling pathway_Homo sapiens_hsa049100.83363185
85Acute myeloid leukemia_Homo sapiens_hsa052210.83205125
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.82542310
87Pancreatic cancer_Homo sapiens_hsa052120.81186772
88Pyruvate metabolism_Homo sapiens_hsa006200.80987761
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80533217
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79061475
91Fanconi anemia pathway_Homo sapiens_hsa034600.78372786
92VEGF signaling pathway_Homo sapiens_hsa043700.78229827
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77508956
94Spliceosome_Homo sapiens_hsa030400.76129960
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75863710
96p53 signaling pathway_Homo sapiens_hsa041150.74944812
97Estrogen signaling pathway_Homo sapiens_hsa049150.74752296
98Arginine and proline metabolism_Homo sapiens_hsa003300.74678372
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.74581545
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74065314
101ErbB signaling pathway_Homo sapiens_hsa040120.73416899
102Axon guidance_Homo sapiens_hsa043600.73141541
103Endometrial cancer_Homo sapiens_hsa052130.73104397
104Galactose metabolism_Homo sapiens_hsa000520.73091104
105Ovarian steroidogenesis_Homo sapiens_hsa049130.72471014
106Purine metabolism_Homo sapiens_hsa002300.71651602
107Choline metabolism in cancer_Homo sapiens_hsa052310.71617579
108Glioma_Homo sapiens_hsa052140.71412413
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69014921
110Viral carcinogenesis_Homo sapiens_hsa052030.67349843
111Viral myocarditis_Homo sapiens_hsa054160.67213447
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.66794409
113HTLV-I infection_Homo sapiens_hsa051660.65820298
114Colorectal cancer_Homo sapiens_hsa052100.65657140
115Cocaine addiction_Homo sapiens_hsa050300.65398800
116Renin secretion_Homo sapiens_hsa049240.64696239
117MAPK signaling pathway_Homo sapiens_hsa040100.64641370
118Folate biosynthesis_Homo sapiens_hsa007900.64597473
119AMPK signaling pathway_Homo sapiens_hsa041520.64164927
120Alcoholism_Homo sapiens_hsa050340.63360837
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61380156
122HIF-1 signaling pathway_Homo sapiens_hsa040660.61224353
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60547604
124Prostate cancer_Homo sapiens_hsa052150.60532569
125Vitamin B6 metabolism_Homo sapiens_hsa007500.59900175
126Adherens junction_Homo sapiens_hsa045200.58625664
127Serotonergic synapse_Homo sapiens_hsa047260.58568580
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57214724
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.56522383
130Vibrio cholerae infection_Homo sapiens_hsa051100.55927406
131Non-small cell lung cancer_Homo sapiens_hsa052230.55449164
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55246430
133Dorso-ventral axis formation_Homo sapiens_hsa043200.55121032
134Melanoma_Homo sapiens_hsa052180.54672903
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54472252
136Inositol phosphate metabolism_Homo sapiens_hsa005620.53372385
137Fatty acid elongation_Homo sapiens_hsa000620.51353910
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48176116
139Rap1 signaling pathway_Homo sapiens_hsa040150.47645834
140Homologous recombination_Homo sapiens_hsa034400.46872545
141Epstein-Barr virus infection_Homo sapiens_hsa051690.45851551
142Prion diseases_Homo sapiens_hsa050200.44020263
143Renal cell carcinoma_Homo sapiens_hsa052110.43122409
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42771998
145Proteasome_Homo sapiens_hsa030500.42363251
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40593593
147Focal adhesion_Homo sapiens_hsa045100.39825926
148Proteoglycans in cancer_Homo sapiens_hsa052050.38897785
149Basal transcription factors_Homo sapiens_hsa030220.37333190

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