TMEM202

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.98130525
2acrosome reaction (GO:0007340)9.37637152
3cell-cell recognition (GO:0009988)8.97435618
4reproduction (GO:0000003)8.80732801
5binding of sperm to zona pellucida (GO:0007339)8.62816206
6axonemal dynein complex assembly (GO:0070286)8.37415002
7motile cilium assembly (GO:0044458)8.36384171
8epithelial cilium movement (GO:0003351)7.72692701
9spermatid development (GO:0007286)7.58634336
10piRNA metabolic process (GO:0034587)7.20949576
11regulation of cilium movement (GO:0003352)6.96372803
12single fertilization (GO:0007338)6.70031381
13male meiosis (GO:0007140)6.66141227
14cilium movement (GO:0003341)6.60928674
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.41006660
16synaptonemal complex organization (GO:0070193)6.17639346
17sperm capacitation (GO:0048240)6.05778118
18synaptonemal complex assembly (GO:0007130)5.86034317
19fertilization (GO:0009566)5.42373967
20spermatogenesis (GO:0007283)4.89337510
21male gamete generation (GO:0048232)4.88552410
22ventricular system development (GO:0021591)4.82050734
23organic cation transport (GO:0015695)4.82030428
24calcium ion-dependent exocytosis (GO:0017156)4.68866328
25negative regulation of inclusion body assembly (GO:0090084)4.65787792
26gamete generation (GO:0007276)4.46386345
27cellular process involved in reproduction in multicellular organism (GO:0022412)4.39097379
28cell recognition (GO:0008037)4.37078043
29microtubule depolymerization (GO:0007019)4.33956185
30protein localization to cilium (GO:0061512)4.27281801
31spermatid nucleus differentiation (GO:0007289)4.26286493
32germ cell development (GO:0007281)4.16739221
33regulation of microtubule-based movement (GO:0060632)4.02351040
34DNA methylation involved in gamete generation (GO:0043046)3.99311277
35chromosome organization involved in meiosis (GO:0070192)3.88087454
36microtubule severing (GO:0051013)3.76816671
37regulation of podosome assembly (GO:0071801)3.63628024
38regulation of inclusion body assembly (GO:0090083)3.60159879
39male meiosis I (GO:0007141)3.57129501
40seminiferous tubule development (GO:0072520)3.56862897
41multicellular organismal reproductive process (GO:0048609)3.53097523
42response to peptidoglycan (GO:0032494)3.43345441
43meiotic nuclear division (GO:0007126)3.42167853
44protein K11-linked deubiquitination (GO:0035871)3.27402122
45monoubiquitinated protein deubiquitination (GO:0035520)3.27070847
46protein polyglutamylation (GO:0018095)3.20722329
47polyol catabolic process (GO:0046174)3.15332171
48ether metabolic process (GO:0018904)3.10520400
49sequestering of actin monomers (GO:0042989)3.00135277
50lactate metabolic process (GO:0006089)2.94312900
51left/right pattern formation (GO:0060972)2.88161321
52multicellular organismal development (GO:0007275)2.87949693
53positive regulation of monocyte chemotaxis (GO:0090026)2.87540736
54regulation of protein polyubiquitination (GO:1902914)2.87326965
55meiotic cell cycle (GO:0051321)2.85045135
56neutrophil activation involved in immune response (GO:0002283)2.78029761
57regulation of response to osmotic stress (GO:0047484)2.73479527
58glycerol ether metabolic process (GO:0006662)2.66898409
59axoneme assembly (GO:0035082)2.59995147
60natural killer cell mediated cytotoxicity (GO:0042267)2.55024118
61natural killer cell mediated immunity (GO:0002228)2.55024118
62phagosome maturation (GO:0090382)2.53966855
63meiosis I (GO:0007127)2.53185726
64chaperone-mediated protein complex assembly (GO:0051131)2.52264912
65polyketide metabolic process (GO:0030638)2.50941753
66doxorubicin metabolic process (GO:0044598)2.50941753
67daunorubicin metabolic process (GO:0044597)2.50941753
68positive regulation of chemokine biosynthetic process (GO:0045080)2.49601523
69genitalia morphogenesis (GO:0035112)2.48166971
70glycolytic process (GO:0006096)2.46552202
71phenylpropanoid metabolic process (GO:0009698)2.46501506
72cellular response to arsenic-containing substance (GO:0071243)2.45998194
73intraciliary transport (GO:0042073)2.45127066
74nucleoside diphosphate phosphorylation (GO:0006165)2.44620614
75modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42714731
76modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42714731
77positive regulation by organism of defense response of other organism involved in symbiotic interact2.42714731
78modulation by symbiont of host immune response (GO:0052553)2.42714731
79positive regulation by symbiont of host defense response (GO:0052509)2.42714731
80modulation by symbiont of host defense response (GO:0052031)2.42714731
81regulation of cytokine production involved in inflammatory response (GO:1900015)2.40577658
82chromosome condensation (GO:0030261)2.37299835
83carnitine transport (GO:0015879)2.36802641
84amino-acid betaine transport (GO:0015838)2.36802641
85microtubule-based movement (GO:0007018)2.36090868
86carnitine transmembrane transport (GO:1902603)2.35862645
87energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.32778747
88ATP hydrolysis coupled proton transport (GO:0015991)2.32778747
89cilium organization (GO:0044782)2.32243418
90cellular component assembly involved in morphogenesis (GO:0010927)2.31572617
91cilium morphogenesis (GO:0060271)2.31548782
92single-organism membrane fusion (GO:0044801)2.30751741
93fusion of sperm to egg plasma membrane (GO:0007342)13.3323002
94cilium or flagellum-dependent cell motility (GO:0001539)11.7703383
95cell wall macromolecule metabolic process (GO:0044036)11.6557004
96cell wall macromolecule catabolic process (GO:0016998)11.6557004
97acrosome assembly (GO:0001675)10.9791322
98multicellular organism reproduction (GO:0032504)10.7404510
99sperm motility (GO:0030317)10.5173955
100plasma membrane fusion (GO:0045026)10.2602664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.97103312
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.37954603
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.28854500
4EZH2_22144423_ChIP-Seq_EOC_Human3.31853899
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.31342033
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.35485685
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.33627157
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.21245228
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.15143737
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01378947
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97424355
12PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.91466369
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.91168651
14IRF8_22096565_ChIP-ChIP_GC-B_Human1.90476593
15ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79712285
16ZNF274_21170338_ChIP-Seq_K562_Hela1.74812867
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68478633
18TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66924068
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57559968
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54793797
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.54223909
22PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45352482
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44794520
24STAT1_17558387_ChIP-Seq_HELA_Human1.43154556
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41977939
26GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.40371649
27TAL1_26923725_Chip-Seq_HPCs_Mouse1.39687438
28CBP_20019798_ChIP-Seq_JUKART_Human1.33771945
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33771945
30KDM2B_26808549_Chip-Seq_REH_Human1.31279799
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29673106
32FLI1_21867929_ChIP-Seq_TH2_Mouse1.28473975
33NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24417903
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23614233
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.23586849
36VDR_24787735_ChIP-Seq_THP-1_Human1.23149282
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.22882637
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22623292
39CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21527646
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21409554
41VDR_22108803_ChIP-Seq_LS180_Human1.21358351
42* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20984569
43GATA3_21867929_ChIP-Seq_TH1_Mouse1.20808744
44CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20740109
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20197434
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19847213
47GF1_26923725_Chip-Seq_HPCs_Mouse1.18856409
48FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18336672
49LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17415648
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17276028
51GATA3_21867929_ChIP-Seq_CD8_Mouse1.16673305
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16589774
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16533014
54RNF2_27304074_Chip-Seq_NSC_Mouse1.14763520
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13268700
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12913442
57SPI1_26923725_Chip-Seq_HPCs_Mouse1.12888602
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11328543
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.10734217
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08126280
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.07321108
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07133335
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06971323
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05214197
65CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04959417
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04549303
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04149774
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03854772
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03159149
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01763583
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.00762047
72SOX2_22085726_ChIP-Seq_NPCs_Mouse1.00539461
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00050350
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98873128
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98858081
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98039737
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97954167
78P53_22387025_ChIP-Seq_ESCs_Mouse0.97807992
79* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97132401
80REST_21632747_ChIP-Seq_MESCs_Mouse0.95750461
81EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94806415
82OCT4_18555785_Chip-Seq_ESCs_Mouse0.94263307
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94212925
84CMYC_18555785_Chip-Seq_ESCs_Mouse0.93866959
85KLF4_18555785_Chip-Seq_ESCs_Mouse0.93517840
86SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92698168
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92620350
88* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92140620
89RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91346943
90STAT3_18555785_Chip-Seq_ESCs_Mouse0.91114963
91FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91010854
92PU1_27457419_Chip-Seq_LIVER_Mouse0.90889274
93SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90431832
94GF1B_26923725_Chip-Seq_HPCs_Mouse0.90352628
95SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90269451
96ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90218917
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88837320
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88786873
99P300_18555785_Chip-Seq_ESCs_Mouse0.88546322
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87568236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.26827991
2MP0001929_abnormal_gametogenesis3.80820641
3MP0008877_abnormal_DNA_methylation3.12494665
4MP0003436_decreased_susceptibility_to2.98592695
5MP0006082_CNS_inflammation2.45978836
6MP0002210_abnormal_sex_determination2.36991315
7MP0002653_abnormal_ependyma_morphology2.32814798
8MP0002161_abnormal_fertility/fecundity2.16700041
9MP0002282_abnormal_trachea_morphology2.15167222
10MP0005410_abnormal_fertilization12.6694395
11MP0001145_abnormal_male_reproductive1.97847733
12MP0003303_peritoneal_inflammation1.91205130
13MP0001835_abnormal_antigen_presentation1.90558731
14MP0009785_altered_susceptibility_to1.89851520
15MP0005623_abnormal_meninges_morphology1.83803367
16MP0002419_abnormal_innate_immunity1.80860367
17MP0001533_abnormal_skeleton_physiology1.75953753
18MP0000653_abnormal_sex_gland1.62967657
19MP0003279_aneurysm1.58842830
20MP0009046_muscle_twitch1.57957973
21MP0000343_altered_response_to1.55330118
22MP0004510_myositis1.51564595
23MP0004858_abnormal_nervous_system1.48443027
24MP0003448_altered_tumor_morphology1.47573425
25MP0002148_abnormal_hypersensitivity_rea1.46523706
26MP0005000_abnormal_immune_tolerance1.44805227
27MP0002405_respiratory_system_inflammati1.44065145
28MP0005025_abnormal_response_to1.39958845
29MP0003011_delayed_dark_adaptation1.36032550
30MP0002332_abnormal_exercise_endurance1.23954263
31MP0004782_abnormal_surfactant_physiolog1.21170699
32MP0001348_abnormal_lacrimal_gland1.19480392
33MP0002452_abnormal_antigen_presenting1.16286056
34MP0004808_abnormal_hematopoietic_stem1.16272635
35MP0003646_muscle_fatigue1.14524009
36MP0003705_abnormal_hypodermis_morpholog1.11744263
37MP0005397_hematopoietic_system_phenotyp1.10504985
38MP0001545_abnormal_hematopoietic_system1.10504985
39MP0003172_abnormal_lysosome_physiology1.09700565
40MP0002735_abnormal_chemical_nociception1.09112091
41MP0009764_decreased_sensitivity_to1.07245766
42MP0005387_immune_system_phenotype1.07055342
43MP0001790_abnormal_immune_system1.07055342
44MP0002933_joint_inflammation1.06655006
45MP0004134_abnormal_chest_morphology1.06258589
46MP0003183_abnormal_peptide_metabolism1.05833034
47MP0002723_abnormal_immune_serum1.05617538
48MP0000569_abnormal_digit_pigmentation1.05039745
49MP0009278_abnormal_bone_marrow1.04211899
50MP0005464_abnormal_platelet_physiology1.00716438
51MP0002736_abnormal_nociception_after0.99283357
52MP0003724_increased_susceptibility_to0.98799696
53MP0005390_skeleton_phenotype0.98128536
54MP0001845_abnormal_inflammatory_respons0.95829427
55MP0010307_abnormal_tumor_latency0.95596513
56MP0002998_abnormal_bone_remodeling0.94748930
57MP0005167_abnormal_blood-brain_barrier0.93734802
58MP0003075_altered_response_to0.93183443
59MP0002160_abnormal_reproductive_system0.92869915
60MP0001853_heart_inflammation0.90803763
61MP0001819_abnormal_immune_cell0.90722929
62MP0002420_abnormal_adaptive_immunity0.90215156
63MP0005166_decreased_susceptibility_to0.85052060
64MP0005503_abnormal_tendon_morphology0.82624852
65MP0000685_abnormal_immune_system0.82016318
66MP0000604_amyloidosis0.80307176
67MP0005670_abnormal_white_adipose0.79540308
68MP0008438_abnormal_cutaneous_collagen0.78295526
69MP0005257_abnormal_intraocular_pressure0.78019108
70MP0008469_abnormal_protein_level0.76344095
71MP0002132_abnormal_respiratory_system0.75678225
72MP0001800_abnormal_humoral_immune0.75503821
73MP0000858_altered_metastatic_potential0.75477493
74MP0003795_abnormal_bone_structure0.74464206
75MP0005023_abnormal_wound_healing0.74305121
76MP0005058_abnormal_lysosome_morphology0.74266441
77MP0005164_abnormal_response_to0.74061542
78MP0004947_skin_inflammation0.71584909
79MP0001851_eye_inflammation0.70012567
80MP0001968_abnormal_touch/_nociception0.66991401
81MP0003950_abnormal_plasma_membrane0.66484879
82MP0010386_abnormal_urinary_bladder0.64382455
83MP0001986_abnormal_taste_sensitivity0.62502506
84MP0002133_abnormal_respiratory_system0.62286179
85MP0005388_respiratory_system_phenotype0.62286179
86MP0003186_abnormal_redox_activity0.61626225
87MP0001501_abnormal_sleep_pattern0.59449796
88MP0008004_abnormal_stomach_pH0.57439454
89MP0002115_abnormal_skeleton_extremities0.56458317
90MP0005671_abnormal_response_to0.56260252
91MP0001984_abnormal_olfaction0.55211581
92MP0002163_abnormal_gland_morphology0.54791183
93MP0000358_abnormal_cell_content/0.54451070
94MP0001958_emphysema0.54391305
95MP0005174_abnormal_tail_pigmentation0.51503840
96MP0000716_abnormal_immune_system0.51169992
97MP0003045_fibrosis0.50258537
98MP0003091_abnormal_cell_migration0.49550912
99MP0002277_abnormal_respiratory_mucosa0.49440729
100MP0000689_abnormal_spleen_morphology0.47036641

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.95304379
2Abnormal respiratory epithelium morphology (HP:0012253)7.49261905
3Abnormal respiratory motile cilium morphology (HP:0005938)7.49261905
4Rhinitis (HP:0012384)7.09572912
5Chronic bronchitis (HP:0004469)6.59851625
6Abnormal ciliary motility (HP:0012262)6.52405081
7Nasal polyposis (HP:0100582)6.30183154
8Infertility (HP:0000789)5.19800914
9Abnormality of the nasal mucosa (HP:0000433)5.13777665
10Bronchitis (HP:0012387)3.95022107
11Bronchiectasis (HP:0002110)3.88788006
12Irregular epiphyses (HP:0010582)3.59442019
13Epiphyseal dysplasia (HP:0002656)3.34516563
14Recurrent sinusitis (HP:0011108)3.14816447
15Vitreoretinal degeneration (HP:0000655)3.12022037
16Male infertility (HP:0003251)3.03577900
17Medial flaring of the eyebrow (HP:0010747)3.00417534
18Nephronophthisis (HP:0000090)2.99573890
19Absent frontal sinuses (HP:0002688)2.96028173
20Recurrent abscess formation (HP:0002722)2.72837596
21Recurrent otitis media (HP:0000403)2.71335913
22Flattened epiphyses (HP:0003071)2.70697048
23Recurrent gram-negative bacterial infections (HP:0005420)2.67582768
24Abnormality of the lower motor neuron (HP:0002366)2.52745322
25Fibular hypoplasia (HP:0003038)2.50183118
26Short femoral neck (HP:0100864)2.45782381
27Absent epiphyses (HP:0010577)2.43600646
28Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.43600646
29Eczematoid dermatitis (HP:0000976)2.41683999
30Chronic sinusitis (HP:0011109)2.39596122
31Abnormal spermatogenesis (HP:0008669)2.31084036
32Recurrent bacterial skin infections (HP:0005406)2.29928561
33Upper motor neuron abnormality (HP:0002127)2.27485793
34Abnormality of the renal medulla (HP:0100957)2.27117760
35Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.25203138
36Abnormality of midbrain morphology (HP:0002418)2.24264270
37Molar tooth sign on MRI (HP:0002419)2.24264270
38Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.20854772
39Congenital primary aphakia (HP:0007707)2.18842326
40Recurrent bronchitis (HP:0002837)2.18469096
41Gait imbalance (HP:0002141)2.17333251
42Small epiphyses (HP:0010585)2.12768755
43Amyotrophic lateral sclerosis (HP:0007354)2.10023929
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4286470
45Absent/shortened dynein arms (HP:0200106)10.5008254
46Dynein arm defect of respiratory motile cilia (HP:0012255)10.5008254
47Azoospermia (HP:0000027)1.98786859
48Cupped ribs (HP:0000887)1.92580973
49Abnormality of the frontal sinuses (HP:0002687)1.90663576
50Orchitis (HP:0100796)1.89389346
51Nephrogenic diabetes insipidus (HP:0009806)1.88718716
52Loss of speech (HP:0002371)1.85189511
53Increased cerebral lipofuscin (HP:0011813)1.84194548
54Tubulointerstitial abnormality (HP:0001969)1.82531477
55Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81053268
56Abnormality of macrophages (HP:0004311)1.80265191
57Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80211541
58Tubulointerstitial fibrosis (HP:0005576)1.78576085
59Asymmetric septal hypertrophy (HP:0001670)1.76994320
60Tongue fasciculations (HP:0001308)1.75003710
61Aplasia/Hypoplasia of the lens (HP:0008063)1.73789838
62Abnormality of femoral epiphyses (HP:0006499)1.72361612
63Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72361612
64Spastic tetraparesis (HP:0001285)1.68606924
65Protuberant abdomen (HP:0001538)1.68139959
66Muscle fibrillation (HP:0010546)1.62839093
67Hypoplastic ischia (HP:0003175)1.62399407
68Abnormality of the epiphysis of the femoral head (HP:0010574)1.60782694
69Tubular atrophy (HP:0000092)1.59776920
70Tubulointerstitial nephritis (HP:0001970)1.58362655
71Gingivitis (HP:0000230)1.57876452
72Impaired proprioception (HP:0010831)1.57011778
73Arthropathy (HP:0003040)1.56885900
74J-shaped sella turcica (HP:0002680)1.56525377
75Myositis (HP:0100614)1.55758721
76Aplasia/hypoplasia of the femur (HP:0005613)1.55259830
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.55149019
78Flat capital femoral epiphysis (HP:0003370)1.54510401
79Abnormality of cochlea (HP:0000375)1.53799986
80Metaphyseal cupping (HP:0003021)1.51686026
81Increased neuronal autofluorescent lipopigment (HP:0002074)1.51498773
82Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51044312
83Osteoarthritis (HP:0002758)1.50219279
84Retrobulbar optic neuritis (HP:0100654)1.49269944
85Optic neuritis (HP:0100653)1.49269944
86Abnormality of the femoral head (HP:0003368)1.49206988
87Congenital hepatic fibrosis (HP:0002612)1.48012326
88Short thorax (HP:0010306)1.47282875
89Disinhibition (HP:0000734)1.46772196
90Poor coordination (HP:0002370)1.44198357
91Mediastinal lymphadenopathy (HP:0100721)1.44092352
92Oculomotor apraxia (HP:0000657)1.43583359
93Vaginal atresia (HP:0000148)1.40745826
94Abnormality of the ischium (HP:0003174)1.39917917
95Postaxial hand polydactyly (HP:0001162)1.39272300
96Mild short stature (HP:0003502)1.38789862
97Delayed epiphyseal ossification (HP:0002663)1.38576643
98Agnosia (HP:0010524)1.38545522
99Abnormality of dentin (HP:0010299)1.38451043
100Short ribs (HP:0000773)1.38181253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.50433192
2PDK47.50433192
3PDK25.55136202
4TESK14.34624913
5PRKD33.40328473
6PTK2B2.58613770
7LMTK22.35267547
8ICK2.23191584
9RIPK41.85763290
10PRKG21.83551852
11PINK11.68109690
12ERN11.42479078
13STK241.42394566
14WNK41.32690355
15TBK11.30318029
16PIM21.29843961
17GRK51.29823924
18STK391.25001378
19STK31.17328225
20CDK121.17227713
21MAP3K31.12508629
22MAPK71.10551820
23KIT1.07517957
24PDK11.04131424
25MST1R0.99024414
26WNK10.97062595
27GRK60.96756991
28STK380.94664586
29STK100.93591311
30MATK0.92902569
31DDR20.90547129
32AKT30.88583508
33MAP3K120.87259941
34MARK30.86384746
35CSF1R0.79077154
36MAP3K50.78684297
37ERBB30.69975236
38PLK20.69519709
39CAMKK10.67833323
40PBK0.66458178
41PAK40.66411469
42STK38L0.65391466
43CSK0.64446403
44IRAK10.62701390
45MAP3K140.61781177
46PRPF4B0.59015047
47ADRBK20.58753352
48ZAP700.58351037
49RIPK10.56471712
50DYRK1B0.54287587
51CAMKK20.52681645
52TYK20.52189145
53MOS0.51763967
54NTRK10.51487381
55MAP2K60.51338182
56PRKCD0.50215612
57BLK0.49931355
58MAP2K30.49237418
59GRK70.48775398
60SIK30.47684176
61BMPR1B0.45441591
62TAOK20.44401117
63EPHB10.44363612
64IKBKE0.42657981
65HCK0.41781861
66NEK20.41634102
67PDPK10.40020271
68TYRO30.39668640
69TGFBR20.39539988
70GRK10.38561518
71BRAF0.36613249
72BMX0.36480773
73ARAF0.34706671
74TRIB30.34457684
75IKBKB0.33414396
76TRPM70.33023740
77TESK20.32273172
78CCNB10.32223745
79DAPK20.31597939
80SCYL20.31544002
81MINK10.29977641
82ADRBK10.29946101
83YES10.29136609
84PAK10.28759094
85JAK30.27820474
86MAP3K110.26782699
87FES0.26178512
88ERBB40.26164259
89IRAK40.25995134
90MAP3K10.24607221
91EGFR0.24247407
92PIM10.24246960
93SYK0.24059998
94FGFR30.24046552
95MAPK40.23762316
96PRKCH0.22576391
97PRKACG0.21846842
98RPS6KA60.20897384
99MAP2K40.20606748
100PRKG10.18840334

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.84471707
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.64519045
3Vitamin B6 metabolism_Homo sapiens_hsa007502.54678867
4Caffeine metabolism_Homo sapiens_hsa002322.53389949
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.41689369
6Collecting duct acid secretion_Homo sapiens_hsa049662.37292069
7Legionellosis_Homo sapiens_hsa051342.15622897
8Rheumatoid arthritis_Homo sapiens_hsa053232.08466157
9Malaria_Homo sapiens_hsa051442.03780742
10Leishmaniasis_Homo sapiens_hsa051401.94873497
11Phagosome_Homo sapiens_hsa041451.86922230
12Synaptic vesicle cycle_Homo sapiens_hsa047211.70230226
13Pentose phosphate pathway_Homo sapiens_hsa000301.66631084
14Salmonella infection_Homo sapiens_hsa051321.61499330
15Pyruvate metabolism_Homo sapiens_hsa006201.59763765
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56531557
17Glucagon signaling pathway_Homo sapiens_hsa049221.54813170
18Tuberculosis_Homo sapiens_hsa051521.47050461
19Osteoclast differentiation_Homo sapiens_hsa043801.42356671
20Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.38280139
21Dorso-ventral axis formation_Homo sapiens_hsa043201.36199903
22Staphylococcus aureus infection_Homo sapiens_hsa051501.34111743
23TNF signaling pathway_Homo sapiens_hsa046681.31180421
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29547569
25Lysosome_Homo sapiens_hsa041421.28314741
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27865142
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26797541
28B cell receptor signaling pathway_Homo sapiens_hsa046621.22262385
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17911831
30Mineral absorption_Homo sapiens_hsa049781.14902459
31Fructose and mannose metabolism_Homo sapiens_hsa000511.14133562
32Influenza A_Homo sapiens_hsa051641.09759909
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09389251
34Antigen processing and presentation_Homo sapiens_hsa046121.09072159
35Fatty acid biosynthesis_Homo sapiens_hsa000611.05151497
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04004862
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03776243
38Pertussis_Homo sapiens_hsa051331.02247240
39Vibrio cholerae infection_Homo sapiens_hsa051101.02133392
40Other glycan degradation_Homo sapiens_hsa005111.01859528
41Shigellosis_Homo sapiens_hsa051311.01303780
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00099453
43Selenocompound metabolism_Homo sapiens_hsa004500.98047771
44Linoleic acid metabolism_Homo sapiens_hsa005910.97859196
45Renin secretion_Homo sapiens_hsa049240.96139935
46African trypanosomiasis_Homo sapiens_hsa051430.92467540
47Glycerolipid metabolism_Homo sapiens_hsa005610.91595845
48Amphetamine addiction_Homo sapiens_hsa050310.91338737
49Graft-versus-host disease_Homo sapiens_hsa053320.87213292
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85920425
51Basal transcription factors_Homo sapiens_hsa030220.85493372
52Toxoplasmosis_Homo sapiens_hsa051450.82151251
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.82016261
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81752880
55Measles_Homo sapiens_hsa051620.79176069
56Arachidonic acid metabolism_Homo sapiens_hsa005900.78864416
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78789988
58VEGF signaling pathway_Homo sapiens_hsa043700.77724771
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77462075
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75163718
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74789105
62Long-term potentiation_Homo sapiens_hsa047200.73002255
63Huntingtons disease_Homo sapiens_hsa050160.72051098
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71480047
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70231736
66Protein digestion and absorption_Homo sapiens_hsa049740.69583985
67Olfactory transduction_Homo sapiens_hsa047400.68605958
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.64029322
69Ether lipid metabolism_Homo sapiens_hsa005650.61632185
70HIF-1 signaling pathway_Homo sapiens_hsa040660.61217032
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61088941
72Hepatitis B_Homo sapiens_hsa051610.60839226
73Allograft rejection_Homo sapiens_hsa053300.60177461
74Type I diabetes mellitus_Homo sapiens_hsa049400.59557306
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58874719
76Apoptosis_Homo sapiens_hsa042100.56114625
77Endocytosis_Homo sapiens_hsa041440.54834124
78Oocyte meiosis_Homo sapiens_hsa041140.54006396
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53697565
80Propanoate metabolism_Homo sapiens_hsa006400.52519897
81Acute myeloid leukemia_Homo sapiens_hsa052210.51258369
82Renin-angiotensin system_Homo sapiens_hsa046140.50399074
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.50012059
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47104750
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45995404
86Inositol phosphate metabolism_Homo sapiens_hsa005620.45734439
87PPAR signaling pathway_Homo sapiens_hsa033200.45390285
88Asthma_Homo sapiens_hsa053100.45132659
89Estrogen signaling pathway_Homo sapiens_hsa049150.44919645
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44191630
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43717460
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43352442
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43270362
94Hematopoietic cell lineage_Homo sapiens_hsa046400.43089074
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.42316843
96ECM-receptor interaction_Homo sapiens_hsa045120.40168741
97Taste transduction_Homo sapiens_hsa047420.40127879
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.39908919
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39867203
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.39397185

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