TMEM203

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.14307786
2negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.32372210
3COPI coating of Golgi vesicle (GO:0048205)4.22166727
4Golgi transport vesicle coating (GO:0048200)4.22166727
5regulation of mammary gland epithelial cell proliferation (GO:0033599)4.13131955
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.05847754
7L-phenylalanine metabolic process (GO:0006558)4.05847754
8DNA unwinding involved in DNA replication (GO:0006268)3.89752990
9positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.89003710
10ribosomal small subunit assembly (GO:0000028)3.81604276
11maturation of SSU-rRNA (GO:0030490)3.76027378
12heterochromatin organization (GO:0070828)3.72337430
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.70286916
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.64831507
15L-phenylalanine catabolic process (GO:0006559)3.64831507
16regulation of early endosome to late endosome transport (GO:2000641)3.63807100
17cotranslational protein targeting to membrane (GO:0006613)3.62313455
18ribonucleoprotein complex biogenesis (GO:0022613)3.61879429
19protein targeting to ER (GO:0045047)3.60793875
20negative regulation of erythrocyte differentiation (GO:0045647)3.59279523
21protein retention in ER lumen (GO:0006621)3.57774173
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56755520
23mitotic chromosome condensation (GO:0007076)3.55410962
24mitochondrial fusion (GO:0008053)3.50936758
25protein localization to endoplasmic reticulum (GO:0070972)3.50718823
26viral transcription (GO:0019083)3.46509795
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45912423
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45912423
29pentose-phosphate shunt (GO:0006098)3.41901957
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.40128460
31ribosomal large subunit biogenesis (GO:0042273)3.39978304
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38797214
33translational termination (GO:0006415)3.36365605
34pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.34566590
35nucleoside salvage (GO:0043174)3.34009380
36regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.30603258
37protein complex disassembly (GO:0043241)3.30066292
38cysteine metabolic process (GO:0006534)3.29906076
39pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.28932367
40pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.26784039
41L-serine metabolic process (GO:0006563)3.26457696
42cellular protein complex localization (GO:0034629)3.25984205
43regulation of translational fidelity (GO:0006450)3.25829243
44serine family amino acid biosynthetic process (GO:0009070)3.25552099
45protein localization to endosome (GO:0036010)3.25110523
46signal peptide processing (GO:0006465)3.24645999
47negative regulation of DNA-templated transcription, elongation (GO:0032785)3.24558885
48NADH metabolic process (GO:0006734)3.24310133
49UTP biosynthetic process (GO:0006228)3.22834401
50translational elongation (GO:0006414)3.19678561
51proteasome assembly (GO:0043248)3.19672481
52Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15197896
53UV protection (GO:0009650)3.14081358
54receptor recycling (GO:0001881)3.13640202
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.09384573
56pteridine-containing compound biosynthetic process (GO:0042559)3.07476269
57protein complex localization (GO:0031503)3.06085045
58galactose catabolic process (GO:0019388)3.03925952
59macromolecular complex disassembly (GO:0032984)3.03730942
60peptidyl-arginine omega-N-methylation (GO:0035247)3.01794132
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01018132
62NADPH regeneration (GO:0006740)3.00738175
63DNA strand elongation involved in DNA replication (GO:0006271)2.99706903
64pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.98300584
65aromatic amino acid family catabolic process (GO:0009074)2.97892402
66CTP metabolic process (GO:0046036)2.97370618
67CTP biosynthetic process (GO:0006241)2.97370618
68DNA strand elongation (GO:0022616)2.96842263
69sulfur amino acid catabolic process (GO:0000098)2.96551662
70guanosine-containing compound biosynthetic process (GO:1901070)2.96034022
71regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.96006519
72positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.96006519
73L-methionine salvage (GO:0071267)2.95895740
74L-methionine biosynthetic process (GO:0071265)2.95895740
75amino acid salvage (GO:0043102)2.95895740
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95001430
77respiratory chain complex IV assembly (GO:0008535)2.91063228
78protein insertion into membrane (GO:0051205)2.89302778
79pinocytosis (GO:0006907)2.89175178
80triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.88736195
81response to pheromone (GO:0019236)2.85350678
82glyoxylate metabolic process (GO:0046487)2.85108814
83UTP metabolic process (GO:0046051)2.84460400
84antigen processing and presentation via MHC class Ib (GO:0002475)2.83839787
85ribosome biogenesis (GO:0042254)2.83472369
86metallo-sulfur cluster assembly (GO:0031163)2.82873548
87iron-sulfur cluster assembly (GO:0016226)2.82873548
88mitotic nuclear envelope reassembly (GO:0007084)2.82229641
89nuclear envelope reassembly (GO:0031468)2.82229641
90serine family amino acid metabolic process (GO:0009069)2.82141706
91ribosomal small subunit biogenesis (GO:0042274)2.82055756
92GTP biosynthetic process (GO:0006183)2.80836250
93formation of translation preinitiation complex (GO:0001731)2.80072888
94activation of MAPKKK activity (GO:0000185)2.79818763
95apoptotic process involved in morphogenesis (GO:0060561)2.79510875
96folic acid metabolic process (GO:0046655)2.78994306
97glycine metabolic process (GO:0006544)2.78522092
98pyrimidine nucleoside salvage (GO:0043097)2.78388009
99pyrimidine-containing compound salvage (GO:0008655)2.78388009
100GDP-mannose metabolic process (GO:0019673)2.77803919
101glucose catabolic process (GO:0006007)2.76894075
102spliceosomal tri-snRNP complex assembly (GO:0000244)2.76291641
103mitochondrial DNA metabolic process (GO:0032042)2.75396842
104heme biosynthetic process (GO:0006783)2.74880706
105negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74678068
106alpha-linolenic acid metabolic process (GO:0036109)2.74263786
107pentose metabolic process (GO:0019321)2.73505109
108deoxyribonucleotide biosynthetic process (GO:0009263)2.72380506
109antigen processing and presentation of endogenous antigen (GO:0019883)2.71110905
110purine-containing compound salvage (GO:0043101)2.71093729
111endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.70382079
112histone arginine methylation (GO:0034969)2.69552875
113regulation of translational termination (GO:0006449)2.69371274
114cellular metabolic compound salvage (GO:0043094)2.68521672
115translation (GO:0006412)2.67221541
116retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.66988697
117modulation by symbiont of host cellular process (GO:0044068)2.66760397
118pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66221212
119translational initiation (GO:0006413)2.65440276
1203-UTR-mediated mRNA stabilization (GO:0070935)2.64976446
121telomere maintenance via semi-conservative replication (GO:0032201)2.63622953
122negative regulation of glycoprotein biosynthetic process (GO:0010561)2.63593105
1234-hydroxyproline metabolic process (GO:0019471)2.63331045
124viral life cycle (GO:0019058)2.63235827
125barbed-end actin filament capping (GO:0051016)2.63181729
126pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.62861426
127pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.62506064
128sulfur amino acid biosynthetic process (GO:0000097)2.62423323
129proline biosynthetic process (GO:0006561)2.61983521
130protein maturation by protein folding (GO:0022417)2.61686903
131protein targeting to mitochondrion (GO:0006626)2.61582059
132T cell apoptotic process (GO:0070231)2.60461893
133nucleobase-containing small molecule interconversion (GO:0015949)2.60113323
134negative regulation of fibrinolysis (GO:0051918)2.60001424
135lysine catabolic process (GO:0006554)2.58350160
136lysine metabolic process (GO:0006553)2.58350160
137folic acid-containing compound biosynthetic process (GO:0009396)2.57001990
138COPII vesicle coating (GO:0048208)2.56146260
139heme metabolic process (GO:0042168)2.54929518
140ethanol oxidation (GO:0006069)2.51419037
1412-deoxyribonucleotide biosynthetic process (GO:0009265)2.50262034
142deoxyribose phosphate biosynthetic process (GO:0046385)2.50262034
143protein targeting to membrane (GO:0006612)2.49653248
144serine family amino acid catabolic process (GO:0009071)2.48637301
145peptidyl-glutamic acid carboxylation (GO:0017187)2.48544269
146protein carboxylation (GO:0018214)2.48544269
147positive regulation of triglyceride lipase activity (GO:0061365)2.47798205
148positive regulation of lipoprotein lipase activity (GO:0051006)2.47798205
149regulation of mitochondrial translation (GO:0070129)2.47420339
150proline metabolic process (GO:0006560)2.45625161
151disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.45041580
152killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.45041580
153positive regulation of triglyceride biosynthetic process (GO:0010867)2.44482002
154mitochondrial calcium ion transport (GO:0006851)2.42868310
155protein autoprocessing (GO:0016540)2.42737675
156antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.42234580
157nucleoside diphosphate biosynthetic process (GO:0009133)2.41736407
158kynurenine metabolic process (GO:0070189)2.41655878
159nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.41610477
160nucleotide salvage (GO:0043173)2.41013505
161bile acid biosynthetic process (GO:0006699)2.40626801
162cellular protein complex disassembly (GO:0043624)2.37773443
163indolalkylamine catabolic process (GO:0046218)2.37599471
164tryptophan catabolic process (GO:0006569)2.37599471
165indole-containing compound catabolic process (GO:0042436)2.37599471
166NADH dehydrogenase complex assembly (GO:0010257)2.36036355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83607863
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.70930288
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.92537694
4E2F7_22180533_ChIP-Seq_HELA_Human2.85537567
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76195591
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62863274
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61731416
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59277901
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.56629395
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.44871212
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34143971
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31172458
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30191702
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.28477641
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27459380
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25816968
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.16577639
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08698337
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.07331672
20* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01316934
21* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00850224
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96797430
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92769943
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89129818
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88043121
26MYC_22102868_ChIP-Seq_BL_Human1.80806084
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80550429
28XRN2_22483619_ChIP-Seq_HELA_Human1.77956526
29* GABP_19822575_ChIP-Seq_HepG2_Human1.75912276
30RACK7_27058665_Chip-Seq_MCF-7_Human1.75011501
31VDR_21846776_ChIP-Seq_THP-1_Human1.73564600
32VDR_23849224_ChIP-Seq_CD4+_Human1.72884964
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72865058
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71677227
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71027335
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70087304
37ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69645517
38* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68131490
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66602318
40DCP1A_22483619_ChIP-Seq_HELA_Human1.66448625
41* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64921019
42* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64519858
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.60067200
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56759796
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56505638
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54920121
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54732059
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.54308362
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52907722
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.52305513
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50368776
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49164946
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48793194
54* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47875590
55FOXP3_21729870_ChIP-Seq_TREG_Human1.47782985
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46969603
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.44546075
58KDM2B_26808549_Chip-Seq_DND41_Human1.43762798
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43446253
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43405533
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42769674
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42101661
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41581388
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40680704
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40571644
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39603508
67P68_20966046_ChIP-Seq_HELA_Human1.39008506
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38710191
69TCF7_22412390_ChIP-Seq_EML_Mouse1.37561949
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35742414
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35283223
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34370752
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33892157
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33869156
75ZNF263_19887448_ChIP-Seq_K562_Human1.33625933
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.33236132
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32736640
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32365153
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30604586
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29500841
81LXR_22158963_ChIP-Seq_LIVER_Mouse1.28715098
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28167029
83* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27674915
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.25232412
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24661853
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22711659
87SPI1_23547873_ChIP-Seq_NB4_Human1.22322058
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22009517
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21400137
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20579859
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19949545
92ATF3_27146783_Chip-Seq_COLON_Human1.19233294
93SCL_19346495_ChIP-Seq_HPC-7_Human1.19128444
94CIITA_25753668_ChIP-Seq_RAJI_Human1.18245462
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18203556
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17828476
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17724001
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.17571705
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17429012
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16553590
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16214183
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15596146
103CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15145506
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14639124
105MAF_26560356_Chip-Seq_TH1_Human1.14430324
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14028005
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12224404
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.12059148
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11537984
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10027351
111VDR_24763502_ChIP-Seq_THP-1_Human1.08176257
112KDM2B_26808549_Chip-Seq_K562_Human1.08166935
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08075294
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.07760501
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07240427
116MAF_26560356_Chip-Seq_TH2_Human1.07002707
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06938113
118YY1_21170310_ChIP-Seq_MESCs_Mouse1.05811906
119UTX_26944678_Chip-Seq_JUKART_Human1.05680777
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05268516
121TFEB_21752829_ChIP-Seq_HELA_Human1.05236072
122LXR_22292898_ChIP-Seq_THP-1_Human1.04967801
123CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04720844
124OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04701354
125TTF2_22483619_ChIP-Seq_HELA_Human1.03995779
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03866884
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03605422
128SMC4_20622854_ChIP-Seq_HELA_Human1.03300037
129BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03236668
130CLOCK_20551151_ChIP-Seq_293T_Human1.03212060
131CTCF_26484167_Chip-Seq_Bcells_Mouse1.03102306
132NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02262243
133TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02134022
134GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01897893
135ELK3_25401928_ChIP-Seq_HUVEC_Human1.01779569
136* TET1_21451524_ChIP-Seq_MESCs_Mouse1.01775056
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01371725
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01350935
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01307762
140KDM5A_27292631_Chip-Seq_BREAST_Human0.99815349
141GATA1_22025678_ChIP-Seq_K562_Human0.98984324
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98093384
143PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97263470
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96762989
145RUNX1_22412390_ChIP-Seq_EML_Mouse0.96573408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.58460645
2MP0003806_abnormal_nucleotide_metabolis4.42849161
3MP0005360_urolithiasis3.52854710
4MP0005365_abnormal_bile_salt3.47973300
5MP0009840_abnormal_foam_cell3.42198298
6MP0002877_abnormal_melanocyte_morpholog2.98433979
7MP0005085_abnormal_gallbladder_physiolo2.87093872
8MP0004233_abnormal_muscle_weight2.78361428
9MP0008260_abnormal_autophagy2.76082596
10MP0004858_abnormal_nervous_system2.48052245
11MP0004185_abnormal_adipocyte_glucose2.47147173
12MP0003123_paternal_imprinting2.44436403
13MP0003656_abnormal_erythrocyte_physiolo2.35226654
14MP0003693_abnormal_embryo_hatching2.35195321
15MP0009379_abnormal_foot_pigmentation2.33233338
16MP0003186_abnormal_redox_activity2.32191673
17MP0005623_abnormal_meninges_morphology2.24318401
18MP0005083_abnormal_biliary_tract2.18201397
19MP0003111_abnormal_nucleus_morphology2.17545396
20MP0009278_abnormal_bone_marrow2.07269857
21MP0001849_ear_inflammation2.06646308
22MP0008875_abnormal_xenobiotic_pharmacok1.99273934
23MP0010329_abnormal_lipoprotein_level1.94367856
24MP0006036_abnormal_mitochondrial_physio1.92990097
25MP0005332_abnormal_amino_acid1.92741111
26MP0003191_abnormal_cellular_cholesterol1.92602239
27MP0003329_amyloid_beta_deposits1.91300939
28MP0000685_abnormal_immune_system1.91020933
29MP0005084_abnormal_gallbladder_morpholo1.84696979
30MP0003195_calcinosis1.84459404
31MP0000609_abnormal_liver_physiology1.83745326
32MP0003436_decreased_susceptibility_to1.75755706
33MP0005220_abnormal_exocrine_pancreas1.70092902
34MP0000678_abnormal_parathyroid_gland1.69588028
35MP0003453_abnormal_keratinocyte_physiol1.67387898
36MP0005501_abnormal_skin_physiology1.66442656
37MP0002396_abnormal_hematopoietic_system1.66349274
38MP0001764_abnormal_homeostasis1.66097955
39MP0003303_peritoneal_inflammation1.60766646
40MP0001835_abnormal_antigen_presentation1.56963319
41MP0003763_abnormal_thymus_physiology1.56789159
42MP0009333_abnormal_splenocyte_physiolog1.56146490
43MP0000747_muscle_weakness1.53835280
44MP0002166_altered_tumor_susceptibility1.52378917
45MP0002089_abnormal_postnatal_growth/wei1.51580318
46MP0009785_altered_susceptibility_to1.48738629
47MP0009643_abnormal_urine_homeostasis1.48578557
48MP0002796_impaired_skin_barrier1.48043002
49MP0005257_abnormal_intraocular_pressure1.47657354
50MP0006054_spinal_hemorrhage1.45049655
51MP0005319_abnormal_enzyme/_coenzyme1.44771546
52MP0000751_myopathy1.44126347
53MP0001666_abnormal_nutrient_absorption1.43904655
54MP0005058_abnormal_lysosome_morphology1.43757724
55MP0005666_abnormal_adipose_tissue1.39604607
56MP0001730_embryonic_growth_arrest1.39508151
57MP0003252_abnormal_bile_duct1.39034108
58MP0009672_abnormal_birth_weight1.36659461
59MP0001545_abnormal_hematopoietic_system1.36056870
60MP0005397_hematopoietic_system_phenotyp1.36056870
61MP0005671_abnormal_response_to1.35943549
62MP0008469_abnormal_protein_level1.34733291
63MP0005584_abnormal_enzyme/coenzyme_acti1.33089820
64MP0000750_abnormal_muscle_regeneration1.32495902
65MP0000598_abnormal_liver_morphology1.31938687
66MP0008932_abnormal_embryonic_tissue1.31854107
67MP0003011_delayed_dark_adaptation1.31102722
68MP0002118_abnormal_lipid_homeostasis1.30739818
69MP0010030_abnormal_orbit_morphology1.29829116
70MP0010094_abnormal_chromosome_stability1.29396429
71MP0000759_abnormal_skeletal_muscle1.28542821
72MP0003566_abnormal_cell_adhesion1.27697329
73MP0002398_abnormal_bone_marrow1.26879788
74MP0005464_abnormal_platelet_physiology1.26096441
75MP0001661_extended_life_span1.25945332
76MP0005076_abnormal_cell_differentiation1.25833734
77MP0005636_abnormal_mineral_homeostasis1.25780393
78MP0000490_abnormal_crypts_of1.25625741
79MP0008438_abnormal_cutaneous_collagen1.24486308
80MP0000689_abnormal_spleen_morphology1.23562840
81MP0000350_abnormal_cell_proliferation1.23137568
82MP0009053_abnormal_anal_canal1.20790824
83MP0005451_abnormal_body_composition1.20642910
84MP0002722_abnormal_immune_system1.17595937
85MP0002429_abnormal_blood_cell1.16548855
86MP0005375_adipose_tissue_phenotype1.16206023
87MP0000003_abnormal_adipose_tissue1.16137287
88MP0005025_abnormal_response_to1.15887478
89MP0003724_increased_susceptibility_to1.13918861
90MP0001800_abnormal_humoral_immune1.13339131
91MP0002723_abnormal_immune_serum1.12646572
92MP0005670_abnormal_white_adipose1.12467700
93MP0000358_abnormal_cell_content/1.12207560
94MP0000716_abnormal_immune_system1.11594758
95MP0001348_abnormal_lacrimal_gland1.11562104
96MP0001853_heart_inflammation1.11221794
97MP0002933_joint_inflammation1.10554850
98MP0004957_abnormal_blastocyst_morpholog1.10080846
99MP0002420_abnormal_adaptive_immunity1.09545439
100MP0002080_prenatal_lethality1.08866175
101MP0001819_abnormal_immune_cell1.08236745
102MP0001944_abnormal_pancreas_morphology1.08180582
103MP0000465_gastrointestinal_hemorrhage1.06682644
104MP0004808_abnormal_hematopoietic_stem1.05142061
105MP0002452_abnormal_antigen_presenting1.03812404
106MP0001845_abnormal_inflammatory_respons1.03239244
107MP0005000_abnormal_immune_tolerance1.03206309
108MP0002419_abnormal_innate_immunity1.02639796
109MP0003075_altered_response_to1.02190960
110MP0001346_abnormal_lacrimal_gland1.02158878
111MP0000313_abnormal_cell_death1.00876328
112MP0005330_cardiomyopathy1.00416973
113MP0010234_abnormal_vibrissa_follicle0.99057009
114MP0000681_abnormal_thyroid_gland0.98401629
115MP0000733_abnormal_muscle_development0.97711551
116MP0004147_increased_porphyrin_level0.96889288
117MP0006035_abnormal_mitochondrial_morpho0.96531277
118MP0001727_abnormal_embryo_implantation0.95067432
119MP0002249_abnormal_larynx_morphology0.94386314
120MP0003172_abnormal_lysosome_physiology0.94375433
121MP0001533_abnormal_skeleton_physiology0.93310892
122MP0003868_abnormal_feces_composition0.91235424
123MP0002693_abnormal_pancreas_physiology0.90859258
124MP0006082_CNS_inflammation0.90790217
125MP0009763_increased_sensitivity_to0.90536215
126MP0000858_altered_metastatic_potential0.89731827
127MP0003183_abnormal_peptide_metabolism0.89193203
128MP0009642_abnormal_blood_homeostasis0.88334021
129MP0002019_abnormal_tumor_incidence0.87554830
130MP0004087_abnormal_muscle_fiber0.87472326
131MP0002060_abnormal_skin_morphology0.87014399
132MP0001881_abnormal_mammary_gland0.84960159
133MP0002078_abnormal_glucose_homeostasis0.84440942
134MP0002138_abnormal_hepatobiliary_system0.82567782
135MP0002909_abnormal_adrenal_gland0.81251029
136MP0004947_skin_inflammation0.80209706
137MP0002405_respiratory_system_inflammati0.80086370
138MP0000604_amyloidosis0.79867901
139MP0003705_abnormal_hypodermis_morpholog0.78225347
140MP0005621_abnormal_cell_physiology0.78084163
141MP0009931_abnormal_skin_appearance0.78064161
142MP0000703_abnormal_thymus_morphology0.77874958
143MP0005409_darkened_coat_color0.75829382
144MP0010630_abnormal_cardiac_muscle0.75634471
145MP0002928_abnormal_bile_duct0.75495442
146MP0003646_muscle_fatigue0.75474573
147MP0009697_abnormal_copulation0.75160638
148MP0002006_tumorigenesis0.75073815
149MP0001873_stomach_inflammation0.74218391
150MP0000343_altered_response_to0.73232176
151MP0002148_abnormal_hypersensitivity_rea0.73083200
152MP0000537_abnormal_urethra_morphology0.73079729
153MP0008007_abnormal_cellular_replicative0.73039059
154MP0005384_cellular_phenotype0.72827732
155MP0005376_homeostasis/metabolism_phenot0.72781213
156MP0003077_abnormal_cell_cycle0.72183651
157MP0003943_abnormal_hepatobiliary_system0.71969722
158MP0008874_decreased_physiological_sensi0.70781948
159MP0001542_abnormal_bone_strength0.67779531
160MP0002998_abnormal_bone_remodeling0.66138780
161MP0001697_abnormal_embryo_size0.65989007
162MP0003942_abnormal_urinary_system0.64783827
163MP0005380_embryogenesis_phenotype0.64462613
164MP0001672_abnormal_embryogenesis/_devel0.64462613
165MP0001216_abnormal_epidermal_layer0.64096460

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.80955057
2Myopathic facies (HP:0002058)3.46264018
3Centrally nucleated skeletal muscle fibers (HP:0003687)3.40211895
4Decreased activity of mitochondrial respiratory chain (HP:0008972)3.38308344
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.38308344
6Achilles tendon contracture (HP:0001771)3.33147657
7Hypoglycemic coma (HP:0001325)3.30087371
8Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22673451
9Ketosis (HP:0001946)3.18716223
10Hyperlipoproteinemia (HP:0010980)3.17655414
11Reduced antithrombin III activity (HP:0001976)3.14890331
12Hepatic necrosis (HP:0002605)3.04867512
13Xanthomatosis (HP:0000991)3.03780177
14Deep venous thrombosis (HP:0002625)2.95670789
15IgM deficiency (HP:0002850)2.90711571
16Abnormality of dicarboxylic acid metabolism (HP:0010995)2.89572729
17Dicarboxylic aciduria (HP:0003215)2.89572729
18Abnormality of the Achilles tendon (HP:0005109)2.89242226
19Generalized aminoaciduria (HP:0002909)2.88180877
20Abnormality of the intrinsic pathway (HP:0010989)2.84355727
21Abnormal number of erythroid precursors (HP:0012131)2.83051530
22Abnormality of fatty-acid metabolism (HP:0004359)2.82608665
23Thrombocytosis (HP:0001894)2.78051771
24Hyperacusis (HP:0010780)2.75977061
25Microvesicular hepatic steatosis (HP:0001414)2.75922632
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75139590
27Abnormality of alanine metabolism (HP:0010916)2.75139590
28Hyperalaninemia (HP:0003348)2.75139590
29Abnormality of cells of the erythroid lineage (HP:0012130)2.74671314
30Intrahepatic cholestasis (HP:0001406)2.71691748
31Hyperammonemia (HP:0001987)2.71053946
32Abnormal tarsal ossification (HP:0008369)2.69451338
33Muscle stiffness (HP:0003552)2.63846798
34Microretrognathia (HP:0000308)2.63114406
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62387327
36Hepatocellular necrosis (HP:0001404)2.60609368
37Trismus (HP:0000211)2.60066924
38Hyperparathyroidism (HP:0000843)2.56982450
39Distal lower limb muscle weakness (HP:0009053)2.55044233
40Hypobetalipoproteinemia (HP:0003563)2.54312730
41Progressive external ophthalmoplegia (HP:0000590)2.54072595
42Increased connective tissue (HP:0009025)2.53808936
43Exercise-induced myalgia (HP:0003738)2.52542844
44Hyperbilirubinemia (HP:0002904)2.50959087
45Elevated erythrocyte sedimentation rate (HP:0003565)2.47618262
46Rhabdomyolysis (HP:0003201)2.47547283
47Petechiae (HP:0000967)2.47167546
48Ketoacidosis (HP:0001993)2.46885451
49Upper motor neuron abnormality (HP:0002127)2.42748308
50Increased muscle lipid content (HP:0009058)2.41471049
51Prolonged partial thromboplastin time (HP:0003645)2.39980054
52Abnormality of skeletal muscle fiber size (HP:0012084)2.38017274
53Late onset (HP:0003584)2.37893000
54Distal lower limb amyotrophy (HP:0008944)2.36439949
55Increased serum ferritin (HP:0003281)2.36254601
56Abnormality of serum amino acid levels (HP:0003112)2.36014934
57Hyperglycinemia (HP:0002154)2.36013428
58Abnormality of iron homeostasis (HP:0011031)2.35607120
59Multiple enchondromatosis (HP:0005701)2.35214448
60Generalized amyotrophy (HP:0003700)2.34940095
61Abnormality of the common coagulation pathway (HP:0010990)2.32414713
62Insomnia (HP:0100785)2.31617252
63Abnormality of the thoracic spine (HP:0100711)2.31083436
64Deep palmar crease (HP:0006191)2.30558759
65Abnormal protein glycosylation (HP:0012346)2.29507749
66Abnormal glycosylation (HP:0012345)2.29507749
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29507749
68Abnormal protein N-linked glycosylation (HP:0012347)2.29507749
69Premature rupture of membranes (HP:0001788)2.29421008
70Nonimmune hydrops fetalis (HP:0001790)2.29380494
71Abnormality of transition element cation homeostasis (HP:0011030)2.25493804
72Long palpebral fissure (HP:0000637)2.25262317
73Polycythemia (HP:0001901)2.23166683
74Abnormality of the heme biosynthetic pathway (HP:0010472)2.22925027
75Protrusio acetabuli (HP:0003179)2.22418282
76Increased serum lactate (HP:0002151)2.22175669
77Beaking of vertebral bodies (HP:0004568)2.20164869
78Cellulitis (HP:0100658)2.20086389
79Abnormality of reticulocytes (HP:0004312)2.20070525
80Increased variability in muscle fiber diameter (HP:0003557)2.19910881
81Lactic acidosis (HP:0003128)2.18537205
82Delayed CNS myelination (HP:0002188)2.18296810
83Progressive muscle weakness (HP:0003323)2.17486500
84Increased intramyocellular lipid droplets (HP:0012240)2.16782752
85Opisthotonus (HP:0002179)2.15058517
86Microcytic anemia (HP:0001935)2.14306136
87Type 1 muscle fiber predominance (HP:0003803)2.14128521
88Fragile skin (HP:0001030)2.12483293
89Vacuolated lymphocytes (HP:0001922)2.12047527
90Abnormality of sulfur amino acid metabolism (HP:0004339)2.11624981
91Pallor (HP:0000980)2.07776161
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07071808
93Dysostosis multiplex (HP:0000943)2.06831683
94Nemaline bodies (HP:0003798)2.06720021
95Dysmetric saccades (HP:0000641)2.06492716
96Lipid accumulation in hepatocytes (HP:0006561)2.06411079
97Abnormal cartilage morphology (HP:0002763)2.06075990
98Metabolic acidosis (HP:0001942)2.05915839
99Muscle fiber inclusion bodies (HP:0100299)2.05407995
100Type I transferrin isoform profile (HP:0003642)2.05126206
101Abnormality of methionine metabolism (HP:0010901)2.05011369
102Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.04005122
103Broad distal phalanx of finger (HP:0009836)2.01677284
104Hyperthyroidism (HP:0000836)2.01382176
105Methylmalonic aciduria (HP:0012120)2.01085380
106Reticulocytopenia (HP:0001896)2.00088856
107Syringomyelia (HP:0003396)2.00052624
108Spinal cord lesions (HP:0100561)2.00052624
109Testicular atrophy (HP:0000029)2.00045634
110Chronic otitis media (HP:0000389)1.99893715
1113-Methylglutaconic aciduria (HP:0003535)1.99523039
112Distal upper limb amyotrophy (HP:0007149)1.98656508
113Upper limb amyotrophy (HP:0009129)1.98656508
114Reticulocytosis (HP:0001923)1.98432495
115Ragged-red muscle fibers (HP:0003200)1.97029718
116Progressive neurologic deterioration (HP:0002344)1.96766647
117Abnormality of the umbilical cord (HP:0010881)1.96415474
118Abnormality of serine family amino acid metabolism (HP:0010894)1.95820830
119Abnormality of glycine metabolism (HP:0010895)1.95820830
120Bulbar palsy (HP:0001283)1.95571377
121Lethargy (HP:0001254)1.95478970
122Hypercortisolism (HP:0001578)1.95110553
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94417470
124Hypertensive crisis (HP:0100735)1.93412020
125Obstructive sleep apnea (HP:0002870)1.93254786
126Macrocytic anemia (HP:0001972)1.92215875
127Brushfield spots (HP:0001088)1.91431398
128Hypolipoproteinemia (HP:0010981)1.90364970
129Nausea (HP:0002018)1.89310588
130Thoracic kyphosis (HP:0002942)1.89251038
131Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88534071
132Vertebral compression fractures (HP:0002953)1.88132311
133Rough bone trabeculation (HP:0100670)1.88039841
134Ulnar bowing (HP:0003031)1.87418796
135Abnormality of the phalanges of the hallux (HP:0010057)1.87060851
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85578783
137Mucopolysacchariduria (HP:0008155)1.84409979
138Urinary glycosaminoglycan excretion (HP:0003541)1.84409979
139Abnormal gallbladder physiology (HP:0012438)1.83748518
140Cholecystitis (HP:0001082)1.83748518
141Abnormality of the tricuspid valve (HP:0001702)1.82972444
142Abnormal foot bone ossification (HP:0010675)1.82723593
143Aplastic anemia (HP:0001915)1.82165807
144Spinal rigidity (HP:0003306)1.81515467
145Asymmetric septal hypertrophy (HP:0001670)1.81006401
146Hypercalcemia (HP:0003072)1.80971905
147Abnormality of the distal phalanges of the toes (HP:0010182)1.80838486
148Foot dorsiflexor weakness (HP:0009027)1.80753054
149Hypoglycemic seizures (HP:0002173)1.80076015
150Mitral regurgitation (HP:0001653)1.80064337
151Exertional dyspnea (HP:0002875)1.80039575
152Fatigue (HP:0012378)1.79981848
153Thoracolumbar scoliosis (HP:0002944)1.78727701
154Joint stiffness (HP:0001387)1.78718278
155Biconcave vertebral bodies (HP:0004586)1.77918880
156Fat malabsorption (HP:0002630)1.77782212
157Back pain (HP:0003418)1.77708119
158Hyperglycinuria (HP:0003108)1.76554481
159Purpura (HP:0000979)1.75739995
160Stridor (HP:0010307)1.74584509
161Growth hormone excess (HP:0000845)1.71679287
162Myoglobinuria (HP:0002913)1.68828760
163Truncus arteriosus (HP:0001660)1.68095914
164Pseudobulbar signs (HP:0002200)1.67575741
165Calcaneovalgus deformity (HP:0001848)1.67404888
166Dysphonia (HP:0001618)1.66295711
167Abnormality of glycolipid metabolism (HP:0010969)1.65714863
168Abnormality of liposaccharide metabolism (HP:0010968)1.65714863
169Abnormality of glycosphingolipid metabolism (HP:0004343)1.65714863
170Rectal prolapse (HP:0002035)1.65104545
171Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.64948241
172Athetosis (HP:0002305)1.64773866
173EMG: myopathic abnormalities (HP:0003458)1.64168261
174Patellar dislocation (HP:0002999)1.62530296
175Gastrointestinal stroma tumor (HP:0100723)1.62244947
176Elbow flexion contracture (HP:0002987)1.61547511
177Depression (HP:0000716)1.60544017
178Visual hallucinations (HP:0002367)1.60523659
179Hand muscle atrophy (HP:0009130)1.60136593
180Overriding aorta (HP:0002623)1.58359039
181Abnormal trabecular bone morphology (HP:0100671)1.57931240
182Abnormality of the foot musculature (HP:0001436)1.57551551
183Genu recurvatum (HP:0002816)1.57285480
184Polygenic inheritance (HP:0010982)1.57097462
185Duplication of thumb phalanx (HP:0009942)1.56870322
186Single umbilical artery (HP:0001195)1.56850018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.50132455
2NME23.96767796
3ERN13.77477558
4FLT33.62475333
5PKN22.97127502
6SMG12.93115900
7TESK22.86593778
8PRPF4B2.86186151
9IRAK32.41110613
10TRIB32.33519652
11MAP4K12.31995324
12MAP3K102.29331783
13KDR2.21673282
14ICK2.17685966
15BUB12.16280005
16NME12.08814403
17STK162.03794585
18EIF2AK12.01670737
19EIF2AK31.95250851
20NEK11.87238340
21ZAP701.85808235
22MAP3K111.79074235
23TTN1.75954755
24TBK11.62186764
25KIT1.56677468
26BLK1.55068670
27SCYL21.49120968
28PIM21.47107803
29WEE11.45859732
30TESK11.45489207
31SIK11.41447188
32MAP2K31.33461465
33PASK1.31285711
34BTK1.30062301
35FGFR41.29166813
36LRRK21.27297915
37TLK11.26360926
38RPS6KA41.23752889
39TYK21.20742978
40ARAF1.20716067
41KSR21.14009460
42MAP3K131.12076519
43EEF2K1.11713547
44DYRK1B1.11203780
45MAP3K31.10995021
46CSF1R1.09284609
47DYRK31.08817485
48MAPKAPK31.05767933
49RIPK11.02815479
50VRK21.02370508
51CAMKK21.01587110
52MAP2K20.99656498
53TGFBR20.98933265
54CDK190.98150651
55NEK20.97331668
56PRKD30.96530548
57LIMK10.95668400
58MAP3K10.95629014
59IRAK20.94586205
60DMPK0.92517747
61MAP3K90.92448460
62TEC0.92399634
63BRAF0.89874931
64GRK60.88091877
65BRSK20.88012255
66MOS0.87733789
67MAP2K60.87680389
68LATS20.86883813
69PDPK10.86369492
70WNK30.85094644
71MAPK150.83882619
72EPHA20.80356708
73CDC70.80040423
74TAOK10.79640138
75ACVR1B0.78004285
76PAK40.77044015
77CDK120.76801144
78SYK0.75732677
79NLK0.72180750
80MAPK110.71872234
81CDK40.71369145
82MTOR0.71191794
83BMX0.69595655
84RAF10.69152992
85RPS6KL10.67665459
86RPS6KC10.67665459
87JAK30.65234730
88PTK20.64372360
89IKBKE0.62621410
90PTK60.62407537
91AURKA0.60858678
92DYRK20.59451579
93IRAK10.59376463
94MAP3K80.59023277
95DAPK10.58978591
96EPHB10.58625367
97PDGFRA0.57947307
98LATS10.57499213
99PRKG20.57018204
100TXK0.56946670
101VRK10.56870071
102TGFBR10.55900357
103MAPK120.55337181
104DAPK30.54222519
105TAOK30.53440635
106HIPK20.51087507
107STK100.50935846
108ILK0.50748857
109BRSK10.50526900
110PDK10.50456765
111MAPK40.48765998
112PIK3CG0.48711119
113AKT20.48620267
114CDK70.47674960
115RPS6KA20.46776654
116NTRK10.46120308
117ALK0.46091204
118LYN0.46059868
119CDK80.45677496
120ABL20.45398430
121JAK20.45374014
122CCNB10.44686993
123PBK0.44585502
124RPS6KA60.44072650
125PRKD20.43314245
126CDK11A0.41783421
127RPS6KB20.41572525
128CDK140.41549726
129IRAK40.41363670
130MARK20.40936275
131ITK0.40360032
132AURKB0.40287906
133CAMK2G0.39991859
134PIM10.39500207
135IKBKB0.38000987
136TAOK20.37648638
137CDK150.37597281
138PAK20.37374202
139STK40.36483334
140EPHA30.35384975
141RPS6KA10.34821173
142MST1R0.34672461
143CHEK20.34668282
144CHEK10.33070854
145TTK0.31932385
146STK240.30582941
147RPS6KA50.27751829
148CLK10.27086955
149MUSK0.26295264
150LCK0.25526439
151CSNK2A10.24108210
152PLK10.23834336
153MAPKAPK50.23492036
154PAK10.23346144

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.11054641
2Protein export_Homo sapiens_hsa030603.07736198
3Ribosome_Homo sapiens_hsa030102.95748165
4Folate biosynthesis_Homo sapiens_hsa007902.58875126
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.46758140
6DNA replication_Homo sapiens_hsa030302.35844104
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27550106
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.26512784
9Proteasome_Homo sapiens_hsa030502.22867188
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06180282
11Pentose phosphate pathway_Homo sapiens_hsa000302.05820561
12Selenocompound metabolism_Homo sapiens_hsa004502.04695202
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.89687064
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86846217
15Fatty acid degradation_Homo sapiens_hsa000711.86065637
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85614702
17Pyrimidine metabolism_Homo sapiens_hsa002401.83290147
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81654251
19Acute myeloid leukemia_Homo sapiens_hsa052211.81302926
20Bladder cancer_Homo sapiens_hsa052191.78399582
21Prion diseases_Homo sapiens_hsa050201.76445226
22Chronic myeloid leukemia_Homo sapiens_hsa052201.69176839
23RNA polymerase_Homo sapiens_hsa030201.69169513
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62265022
25Caffeine metabolism_Homo sapiens_hsa002321.59946548
26Peroxisome_Homo sapiens_hsa041461.59070200
27VEGF signaling pathway_Homo sapiens_hsa043701.57278529
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.51870611
29Biosynthesis of amino acids_Homo sapiens_hsa012301.51519720
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.49466962
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.49448584
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.48944223
33Carbon metabolism_Homo sapiens_hsa012001.44329820
34Propanoate metabolism_Homo sapiens_hsa006401.44278364
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43237512
36Non-small cell lung cancer_Homo sapiens_hsa052231.42447569
37N-Glycan biosynthesis_Homo sapiens_hsa005101.41662246
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41464520
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39122658
40Pyruvate metabolism_Homo sapiens_hsa006201.35800800
41B cell receptor signaling pathway_Homo sapiens_hsa046621.34366099
42Tryptophan metabolism_Homo sapiens_hsa003801.32549302
43Pancreatic cancer_Homo sapiens_hsa052121.26384011
44Sulfur metabolism_Homo sapiens_hsa009201.25245367
45Fatty acid metabolism_Homo sapiens_hsa012121.21964459
46Complement and coagulation cascades_Homo sapiens_hsa046101.15827307
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14243556
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13120831
49Notch signaling pathway_Homo sapiens_hsa043301.12043724
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10217865
51Mismatch repair_Homo sapiens_hsa034301.08967477
52Base excision repair_Homo sapiens_hsa034101.05235462
53Spliceosome_Homo sapiens_hsa030401.05184655
54Fatty acid elongation_Homo sapiens_hsa000621.05081894
55Vibrio cholerae infection_Homo sapiens_hsa051101.04360682
56Other glycan degradation_Homo sapiens_hsa005111.03139742
57One carbon pool by folate_Homo sapiens_hsa006701.03134386
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02172871
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99647741
60Staphylococcus aureus infection_Homo sapiens_hsa051500.98620516
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95794724
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95680154
63Histidine metabolism_Homo sapiens_hsa003400.95228140
64Galactose metabolism_Homo sapiens_hsa000520.93878341
65PPAR signaling pathway_Homo sapiens_hsa033200.92335765
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92097166
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91911818
68Glioma_Homo sapiens_hsa052140.90271655
69Endometrial cancer_Homo sapiens_hsa052130.88523216
70Fat digestion and absorption_Homo sapiens_hsa049750.88291110
71Butanoate metabolism_Homo sapiens_hsa006500.88189799
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88171319
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.87696404
74Renal cell carcinoma_Homo sapiens_hsa052110.87647476
75Glutathione metabolism_Homo sapiens_hsa004800.87606311
76Insulin signaling pathway_Homo sapiens_hsa049100.87218629
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86200094
78Arginine and proline metabolism_Homo sapiens_hsa003300.85898872
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85475486
80Apoptosis_Homo sapiens_hsa042100.81873766
81Parkinsons disease_Homo sapiens_hsa050120.81599762
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81321871
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80244228
84Chemical carcinogenesis_Homo sapiens_hsa052040.79997430
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79137253
86Shigellosis_Homo sapiens_hsa051310.78697378
87HTLV-I infection_Homo sapiens_hsa051660.78347989
88mRNA surveillance pathway_Homo sapiens_hsa030150.78169948
89Metabolic pathways_Homo sapiens_hsa011000.77824282
90Primary immunodeficiency_Homo sapiens_hsa053400.76505436
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.76347587
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76309144
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76243896
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75537337
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75220065
96Arginine biosynthesis_Homo sapiens_hsa002200.75110282
97Starch and sucrose metabolism_Homo sapiens_hsa005000.73353756
98ErbB signaling pathway_Homo sapiens_hsa040120.72829907
99Fructose and mannose metabolism_Homo sapiens_hsa000510.72122861
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71203382
101Viral carcinogenesis_Homo sapiens_hsa052030.71077670
102Purine metabolism_Homo sapiens_hsa002300.70840169
103Nucleotide excision repair_Homo sapiens_hsa034200.69494187
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69308669
105Retinol metabolism_Homo sapiens_hsa008300.68907472
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.68814794
107Vitamin digestion and absorption_Homo sapiens_hsa049770.67453000
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66602769
109Epstein-Barr virus infection_Homo sapiens_hsa051690.66149885
110Synaptic vesicle cycle_Homo sapiens_hsa047210.65137036
111Lysosome_Homo sapiens_hsa041420.63388773
112Oxidative phosphorylation_Homo sapiens_hsa001900.61920383
113Vitamin B6 metabolism_Homo sapiens_hsa007500.60810124
114Salmonella infection_Homo sapiens_hsa051320.59572658
115Regulation of autophagy_Homo sapiens_hsa041400.59111363
116beta-Alanine metabolism_Homo sapiens_hsa004100.59034657
117Homologous recombination_Homo sapiens_hsa034400.58042037
118RNA transport_Homo sapiens_hsa030130.57794691
119Hepatitis B_Homo sapiens_hsa051610.56080066
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55581763
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.55238695
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.53832015
123Legionellosis_Homo sapiens_hsa051340.53315262
124Colorectal cancer_Homo sapiens_hsa052100.52691272
125mTOR signaling pathway_Homo sapiens_hsa041500.52495590
126Endocytosis_Homo sapiens_hsa041440.52283212
127AMPK signaling pathway_Homo sapiens_hsa041520.51800383
128Viral myocarditis_Homo sapiens_hsa054160.48726513
129Phenylalanine metabolism_Homo sapiens_hsa003600.48638001
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47750803
131Systemic lupus erythematosus_Homo sapiens_hsa053220.47006249
132Melanoma_Homo sapiens_hsa052180.46656904
133Hepatitis C_Homo sapiens_hsa051600.46153161
134Long-term potentiation_Homo sapiens_hsa047200.45902987
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45811330
136Osteoclast differentiation_Homo sapiens_hsa043800.45018689
137Small cell lung cancer_Homo sapiens_hsa052220.42841713
138p53 signaling pathway_Homo sapiens_hsa041150.42470419
139Cell cycle_Homo sapiens_hsa041100.41368907
140Tyrosine metabolism_Homo sapiens_hsa003500.40930500
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40823153
142Antigen processing and presentation_Homo sapiens_hsa046120.39828115
143ABC transporters_Homo sapiens_hsa020100.38931450
144RNA degradation_Homo sapiens_hsa030180.38572533
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38160789
146Glycerolipid metabolism_Homo sapiens_hsa005610.38039695
147Steroid biosynthesis_Homo sapiens_hsa001000.35078260
148Thyroid cancer_Homo sapiens_hsa052160.34847923
149Huntingtons disease_Homo sapiens_hsa050160.34015844
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33776960
151Alzheimers disease_Homo sapiens_hsa050100.33593245
152AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32402180
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32236850
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.30885494

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