ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-phenylalanine catabolic process (GO:0006559)	7.46797390
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.46797390
3	L-phenylalanine metabolic process (GO:0006558)	7.15438868
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.15438868
5	aromatic amino acid family catabolic process (GO:0009074)	6.63050024
6	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.08396271
7	tryptophan catabolic process (GO:0006569)	5.90088356
8	indole-containing compound catabolic process (GO:0042436)	5.90088356
9	indolalkylamine catabolic process (GO:0046218)	5.90088356
10	bile acid biosynthetic process (GO:0006699)	5.77506292
11	glyoxylate metabolic process (GO:0046487)	5.75170928
12	kynurenine metabolic process (GO:0070189)	5.69470293
13	tryptophan metabolic process (GO:0006568)	5.58204734
14	high-density lipoprotein particle remodeling (GO:0034375)	5.41105756
15	alpha-linolenic acid metabolic process (GO:0036109)	5.39651815
16	sulfur amino acid catabolic process (GO:0000098)	5.34183172
17	urea cycle (GO:0000050)	5.28648588
18	urea metabolic process (GO:0019627)	5.28648588
19	cysteine metabolic process (GO:0006534)	5.24925480
20	negative regulation of fibrinolysis (GO:0051918)	5.19910268
21	protein carboxylation (GO:0018214)	5.09141335
22	peptidyl-glutamic acid carboxylation (GO:0017187)	5.09141335
23	complement activation, alternative pathway (GO:0006957)	5.05870735
24	regulation of fibrinolysis (GO:0051917)	5.04448105
25	regulation of protein activation cascade (GO:2000257)	4.94285572
26	nitrogen cycle metabolic process (GO:0071941)	4.93477597
27	bile acid metabolic process (GO:0008206)	4.90951847
28	serine family amino acid catabolic process (GO:0009071)	4.90011057
29	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.88108439
30	aromatic amino acid family metabolic process (GO:0009072)	4.84613879
31	regulation of cholesterol esterification (GO:0010872)	4.77631961
32	regulation of triglyceride catabolic process (GO:0010896)	4.75411239
33	reverse cholesterol transport (GO:0043691)	4.72298516
34	tyrosine metabolic process (GO:0006570)	4.70667184
35	plasma lipoprotein particle remodeling (GO:0034369)	4.64019206
36	protein-lipid complex remodeling (GO:0034368)	4.64019206
37	macromolecular complex remodeling (GO:0034367)	4.64019206
38	regulation of complement activation (GO:0030449)	4.62333163
39	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.59674005
40	homocysteine metabolic process (GO:0050667)	4.58188587
41	alpha-amino acid catabolic process (GO:1901606)	4.52421620
42	acylglycerol homeostasis (GO:0055090)	4.48689961
43	triglyceride homeostasis (GO:0070328)	4.48689961
44	lysine catabolic process (GO:0006554)	4.48536092
45	lysine metabolic process (GO:0006553)	4.48536092
46	amino-acid betaine metabolic process (GO:0006577)	4.48221357
47	phospholipid efflux (GO:0033700)	4.41564474
48	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.41285020
49	coenzyme catabolic process (GO:0009109)	4.39523710
50	cellular ketone body metabolic process (GO:0046950)	4.38657025
51	negative regulation of cholesterol transport (GO:0032375)	4.36797601
52	negative regulation of sterol transport (GO:0032372)	4.36797601
53	plasma lipoprotein particle clearance (GO:0034381)	4.34809888
54	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.32665932
55	protein maturation by protein folding (GO:0022417)	4.32259099
56	cellular glucuronidation (GO:0052695)	4.25387858
57	respiratory electron transport chain (GO:0022904)	4.23116116
58	indolalkylamine metabolic process (GO:0006586)	4.22844779
59	cellular amino acid catabolic process (GO:0009063)	4.20763989
60	aldehyde catabolic process (GO:0046185)	4.19578870
61	electron transport chain (GO:0022900)	4.18141069
62	cellular biogenic amine catabolic process (GO:0042402)	4.17061381
63	amine catabolic process (GO:0009310)	4.17061381
64	glycine metabolic process (GO:0006544)	4.14059151
65	bile acid and bile salt transport (GO:0015721)	4.11880105
66	benzene-containing compound metabolic process (GO:0042537)	4.10863182
67	ethanol oxidation (GO:0006069)	4.09723686
68	serine family amino acid metabolic process (GO:0009069)	4.07902569
69	cholesterol efflux (GO:0033344)	4.07126426
70	imidazole-containing compound metabolic process (GO:0052803)	4.06164848
71	glutamate metabolic process (GO:0006536)	4.01766441
72	chaperone-mediated protein transport (GO:0072321)	4.01635878
73	GDP-mannose metabolic process (GO:0019673)	3.97185070
74	cellular modified amino acid catabolic process (GO:0042219)	3.96867738
75	protein complex biogenesis (GO:0070271)	3.96410234
76	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.94755351
77	ATP synthesis coupled proton transport (GO:0015986)	3.94755351
78	serine family amino acid biosynthetic process (GO:0009070)	3.93545098
79	low-density lipoprotein particle remodeling (GO:0034374)	3.90860981
80	arginine metabolic process (GO:0006525)	3.88140076
81	glucuronate metabolic process (GO:0019585)	3.87293580
82	uronic acid metabolic process (GO:0006063)	3.87293580
83	short-chain fatty acid metabolic process (GO:0046459)	3.87278530
84	cofactor catabolic process (GO:0051187)	3.86566391
85	positive regulation of lipoprotein lipase activity (GO:0051006)	3.85154967
86	positive regulation of triglyceride lipase activity (GO:0061365)	3.85154967
87	drug catabolic process (GO:0042737)	3.84655518
88	plasma lipoprotein particle assembly (GO:0034377)	3.80346167
89	ketone body metabolic process (GO:1902224)	3.80221104
90	fibrinolysis (GO:0042730)	3.78057262
91	carboxylic acid catabolic process (GO:0046395)	3.77835362
92	organic acid catabolic process (GO:0016054)	3.77835362
93	negative regulation of lipase activity (GO:0060192)	3.75184628
94	acetyl-CoA metabolic process (GO:0006084)	3.73879622
95	regulation of cellular amino acid metabolic process (GO:0006521)	3.68226771
96	blood coagulation, intrinsic pathway (GO:0007597)	3.67701103
97	mitochondrial respiratory chain complex assembly (GO:0033108)	3.66512482
98	dicarboxylic acid biosynthetic process (GO:0043650)	3.64750218
99	cholesterol homeostasis (GO:0042632)	3.62124747
100	regulation of mitochondrial translation (GO:0070129)	3.61672543
101	very-low-density lipoprotein particle assembly (GO:0034379)	3.61662134
102	positive regulation of lipid catabolic process (GO:0050996)	3.60194082
103	GTP biosynthetic process (GO:0006183)	3.59677046
104	proteasome assembly (GO:0043248)	3.58626045
105	response to nitrosative stress (GO:0051409)	3.57558536
106	monocarboxylic acid catabolic process (GO:0072329)	3.57537285
107	sterol homeostasis (GO:0055092)	3.55820097
108	fatty acid beta-oxidation (GO:0006635)	3.55066668
109	metallo-sulfur cluster assembly (GO:0031163)	3.54669330
110	iron-sulfur cluster assembly (GO:0016226)	3.54669330
111	fatty acid oxidation (GO:0019395)	3.54154859
112	complement activation, classical pathway (GO:0006958)	3.52827533
113	NAD biosynthetic process (GO:0009435)	3.52689008
114	plasma lipoprotein particle organization (GO:0071827)	3.52585248
115	protein activation cascade (GO:0072376)	3.52558964
116	flavonoid metabolic process (GO:0009812)	3.51881000
117	cytochrome complex assembly (GO:0017004)	3.51774980
118	complement activation (GO:0006956)	3.51730830
119	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.50758041
120	respiratory chain complex IV assembly (GO:0008535)	3.49335438
121	NADH metabolic process (GO:0006734)	3.38573039
122	nucleotide salvage (GO:0043173)	3.37445538
123	branched-chain amino acid catabolic process (GO:0009083)	3.36155750
124	positive regulation of cellular amine metabolic process (GO:0033240)	3.34583400
125	guanosine-containing compound biosynthetic process (GO:1901070)	3.34517657
126	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.33475943
127	NADH dehydrogenase complex assembly (GO:0010257)	3.33475943
128	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.33475943
129	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.32826351
130	base-excision repair, AP site formation (GO:0006285)	3.31083771
131	deoxyribonucleotide catabolic process (GO:0009264)	3.30916374
132	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.29403799
133	purine deoxyribonucleotide catabolic process (GO:0009155)	3.24869572
134	oxidative phosphorylation (GO:0006119)	3.20735967
135	pentose metabolic process (GO:0019321)	3.18036256
136	UTP biosynthetic process (GO:0006228)	3.14559594
137	protein targeting to mitochondrion (GO:0006626)	3.11812030
138	purine nucleotide salvage (GO:0032261)	3.09310999
139	mannosylation (GO:0097502)	3.07826587
140	ATP hydrolysis coupled proton transport (GO:0015991)	3.05593064
141	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.05593064
142	purine deoxyribonucleotide metabolic process (GO:0009151)	3.03955755
143	deoxyribose phosphate catabolic process (GO:0046386)	3.03531670
144	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.02088492
145	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.97445760
146	regulation of cellular amine metabolic process (GO:0033238)	2.96593803
147	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.93951984
148	CTP biosynthetic process (GO:0006241)	2.93529754
149	CTP metabolic process (GO:0046036)	2.93529754
150	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.91503453
151	xenobiotic catabolic process (GO:0042178)	2.90496695
152	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.87467443
153	nucleoside salvage (GO:0043174)	2.87082054
154	UTP metabolic process (GO:0046051)	2.86393581
155	oxaloacetate metabolic process (GO:0006107)	2.84490964
156	establishment of protein localization to mitochondrion (GO:0072655)	2.84169494
157	hydrogen ion transmembrane transport (GO:1902600)	2.83780041
158	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.82452507
159	branched-chain amino acid metabolic process (GO:0009081)	2.82099142
160	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.80419154
161	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.78896713
162	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.78896713
163	2-deoxyribonucleotide metabolic process (GO:0009394)	2.78078878
164	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.77392761
165	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.77279951
166	negative regulation of ligase activity (GO:0051352)	2.77279951
167	amyloid precursor protein catabolic process (GO:0042987)	2.76790631
168	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.75758191
169	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.75014948
170	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.75014948
171	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.75014948
172	ubiquinone biosynthetic process (GO:0006744)	2.73981174
173	deoxyribose phosphate biosynthetic process (GO:0046385)	2.73921689
174	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.73921689
175	polyketide metabolic process (GO:0030638)	2.73821735
176	doxorubicin metabolic process (GO:0044598)	2.73821735
177	daunorubicin metabolic process (GO:0044597)	2.73821735
178	pyrimidine-containing compound salvage (GO:0008655)	2.73430624
179	pyrimidine nucleoside salvage (GO:0043097)	2.73430624
180	ATP biosynthetic process (GO:0006754)	2.73196701
181	heme metabolic process (GO:0042168)	2.71441051
182	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.70439832
183	lipopolysaccharide biosynthetic process (GO:0009103)	2.69923906
184	protein localization to mitochondrion (GO:0070585)	2.69427035
185	L-serine metabolic process (GO:0006563)	2.69291186
186	deoxyribose phosphate metabolic process (GO:0019692)	2.66849441
187	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.66319322
188	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.66319322
189	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.64619777
190	autophagic vacuole fusion (GO:0000046)	2.63995897

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	8.08064628
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.90577529
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.83050091
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.22877178
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.30585034
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.14747731
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	5.03456756
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.24808365
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.96409238
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.88471219
11	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.74171893
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.37789088
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.94129782
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.69566420
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.56492646
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.45235459
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.32498949
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.32130414
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.25784880
20	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.14613061
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.12433306
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.05975701
23	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.01032070
24	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.5646900
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.99334418
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.99051649
27	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.98666162
28	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.93957291
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.91229349
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.82283537
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.81058729
32	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.77446876
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.75884784
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.72665066
35	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.69048771
36	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.65147249
37	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.64818295
38	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.60431831
39	HTT_18923047_ChIP-ChIP_STHdh_Human	1.60112295
40	XRN2_22483619_ChIP-Seq_HELA_Human	1.58085943
41	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56856975
42	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.55829663
43	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.53265701
44	* BCL6_27268052_Chip-Seq_Bcells_Human	1.52535945
45	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.51769187
46	* P68_20966046_ChIP-Seq_HELA_Human	1.51740428
47	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.50577906
48	DCP1A_22483619_ChIP-Seq_HELA_Human	1.48098424
49	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.48022866
50	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.47743181
51	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.46066823
52	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.45087947
53	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.45082565
54	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.44883296
55	GATA1_22025678_ChIP-Seq_K562_Human	1.44847692
56	CLOCK_20551151_ChIP-Seq_293T_Human	1.44843210
57	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.40172126
58	* BCOR_27268052_Chip-Seq_Bcells_Human	1.35643339
59	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.35569300
60	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.33843548
61	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.33325954
62	VDR_21846776_ChIP-Seq_THP-1_Human	1.32575606
63	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.32350351
64	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.31496675
65	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.30234519
66	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.29117279
67	VDR_23849224_ChIP-Seq_CD4+_Human	1.25900034
68	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.25281017
69	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.22806091
70	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.20614917
71	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.19810195
72	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.19451841
73	E2F1_20622854_ChIP-Seq_HELA_Human	1.18814393
74	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.17191186
75	* CTCF_20526341_ChIP-Seq_ESCs_Human	1.17121650
76	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16634122
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.16316295
78	KDM5A_27292631_Chip-Seq_BREAST_Human	1.15271339
79	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.14473025
80	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.12858954
81	PHF8_20622854_ChIP-Seq_HELA_Human	1.10676152
82	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.08602677
83	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.07881840
84	SA1_27219007_Chip-Seq_Bcells_Human	1.07369131
85	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.06312937
86	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.06163251
87	SMC4_20622854_ChIP-Seq_HELA_Human	1.05963313
88	TTF2_22483619_ChIP-Seq_HELA_Human	1.01943225
89	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.01864919
90	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.00946496
91	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.00714095
92	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.00656013
93	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.00537184
94	* P300_27268052_Chip-Seq_Bcells_Human	0.99023767
95	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.98646551
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.97775609
97	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.97237634
98	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.97079798
99	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.96854940
100	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.95650386
101	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.95153932
102	* SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.90250740
103	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.87195221
104	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.86281874
105	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.84740506
106	GATA4_25053715_ChIP-Seq_YYC3_Human	0.83926836
107	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.82106126
108	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.81560228
109	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.81427186
110	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.77388870
111	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.75105531
112	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.73042404
113	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.72140606
114	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.72140606
115	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.71218771
116	* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.71192602
117	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.70148469
118	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.69009844
119	* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.68489222
120	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.66218258
121	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.66092891
122	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.65450905
123	* AR_20517297_ChIP-Seq_VCAP_Human	0.65203522
124	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.64644027
125	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.64368877
126	CEBPB_22108803_ChIP-Seq_LS180_Human	0.63171416
127	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.62809375
128	EGR1_19032775_ChIP-ChIP_M12_Human	0.62779149
129	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.62383272
130	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.60104129
131	MYC_19915707_ChIP-ChIP_AK7_Human	0.58356117
132	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.56988264
133	ZNF263_19887448_ChIP-Seq_K562_Human	0.56323477
134	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.55466090
135	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.55289037
136	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.54592047
137	LXR_22292898_ChIP-Seq_THP-1_Human	0.54238654
138	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.53679864
139	* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.53496509
140	STAT1_17558387_ChIP-Seq_HELA_Human	0.53105651
141	P53_21459846_ChIP-Seq_SAOS-2_Human	0.52614997
142	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.51825390
143	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.51145614
144	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.50574711
145	TAF15_26573619_Chip-Seq_HEK293_Human	0.49854381
146	ERG_20517297_ChIP-Seq_VCAP_Human	0.49468608
147	CBP_21632823_ChIP-Seq_H3396_Human	0.49458532
148	TAF2_19829295_ChIP-Seq_ESCs_Human	0.49098599
149	* FOXA1_25552417_ChIP-Seq_VCAP_Human	0.48428094
150	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.48386296
151	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.43386495
152	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.43148880
153	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.42716378
154	OCT4_20526341_ChIP-Seq_ESCs_Human	0.42630982
155	SOX2_20726797_ChIP-Seq_SW620_Human	0.42580472
156	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.42232638
157	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.41063690
158	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.40878688
159	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.40699978
160	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.40616026
161	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.40229260
162	GATA1_19941826_ChIP-Seq_K562_Human	0.40047698
163	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.39952461
164	GATA2_19941826_ChIP-Seq_K562_Human	0.39627883
165	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.39204575
166	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.38816478
167	NCOR_22424771_ChIP-Seq_293T_Human	0.38614792
168	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.38225626
169	* GATA1_19941827_ChIP-Seq_MEL_Mouse	0.37794155
170	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.37674487
171	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.37645592
172	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.37589054

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.14640392
2	MP0005360_urolithiasis	7.31817940
3	MP0005085_abnormal_gallbladder_physiolo	6.22308737
4	MP0005365_abnormal_bile_salt	6.00615623
5	MP0008875_abnormal_xenobiotic_pharmacok	5.13768752
6	MP0003806_abnormal_nucleotide_metabolis	4.31129471
7	MP0003252_abnormal_bile_duct	3.72897850
8	MP0010329_abnormal_lipoprotein_level	3.52874027
9	MP0009840_abnormal_foam_cell	3.26671188
10	MP0005083_abnormal_biliary_tract	3.00648340
11	MP0005332_abnormal_amino_acid	2.91676497
12	MP0003195_calcinosis	2.90708118
13	MP0001666_abnormal_nutrient_absorption	2.58379316
14	MP0003191_abnormal_cellular_cholesterol	2.42214105
15	MP0004019_abnormal_vitamin_homeostasis	2.20588992
16	MP0002118_abnormal_lipid_homeostasis	2.15218403
17	MP0002653_abnormal_ependyma_morphology	2.08867811
18	MP0000609_abnormal_liver_physiology	2.07079662
19	MP0002138_abnormal_hepatobiliary_system	1.87321133
20	MP0005319_abnormal_enzyme/_coenzyme	1.87102438
21	MP0003868_abnormal_feces_composition	1.78174179
22	MP0001764_abnormal_homeostasis	1.78101313
23	MP0003172_abnormal_lysosome_physiology	1.67546601
24	MP0005584_abnormal_enzyme/coenzyme_acti	1.67293977
25	MP0001905_abnormal_dopamine_level	1.66999285
26	MP0009697_abnormal_copulation	1.59462579
27	MP0003186_abnormal_redox_activity	1.59455949
28	MP0005451_abnormal_body_composition	1.59133816
29	MP0003011_delayed_dark_adaptation	1.53158012
30	MP0003123_paternal_imprinting	1.40523654
31	MP0000681_abnormal_thyroid_gland	1.39071030
32	MP0009643_abnormal_urine_homeostasis	1.38255863
33	MP0005410_abnormal_fertilization	1.37311992
34	MP0005646_abnormal_pituitary_gland	1.37149017
35	MP0002148_abnormal_hypersensitivity_rea	1.34173952
36	MP0003656_abnormal_erythrocyte_physiolo	1.30575676
37	MP0003878_abnormal_ear_physiology	1.27670104
38	MP0005377_hearing/vestibular/ear_phenot	1.27670104
39	MP0010386_abnormal_urinary_bladder	1.26991705
40	MP0002736_abnormal_nociception_after	1.20818837
41	MP0001968_abnormal_touch/_nociception	1.20601285
42	MP0005647_abnormal_sex_gland	1.15358937
43	MP0008260_abnormal_autophagy	1.14897930
44	MP0000598_abnormal_liver_morphology	1.12551763
45	MP0003879_abnormal_hair_cell	1.12274633
46	MP0005075_abnormal_melanosome_morpholog	1.11140005
47	MP0000372_irregular_coat_pigmentation	1.10504222
48	MP0005165_increased_susceptibility_to	1.09966976
49	MP0002909_abnormal_adrenal_gland	1.09943893
50	MP0009764_decreased_sensitivity_to	1.09743954
51	MP0003786_premature_aging	1.09212782
52	MP0005636_abnormal_mineral_homeostasis	1.06829195
53	MP0006036_abnormal_mitochondrial_physio	1.06754071
54	MP0000604_amyloidosis	1.04250133
55	MP0002254_reproductive_system_inflammat	1.04235455
56	MP0005330_cardiomyopathy	1.03599378
57	MP0009763_increased_sensitivity_to	0.99154764
58	MP0002876_abnormal_thyroid_physiology	0.98647251
59	MP0005670_abnormal_white_adipose	0.98356506
60	MP0000358_abnormal_cell_content/	0.96453606
61	MP0005379_endocrine/exocrine_gland_phen	0.96021427
62	MP0005408_hypopigmentation	0.95996847
63	MP0008469_abnormal_protein_level	0.93297056
64	MP0002277_abnormal_respiratory_mucosa	0.90683009
65	MP0009642_abnormal_blood_homeostasis	0.89696988
66	MP0010368_abnormal_lymphatic_system	0.89489374
67	MP0003690_abnormal_glial_cell	0.88891148
68	MP0009785_altered_susceptibility_to	0.86195877
69	MP0000343_altered_response_to	0.85710382
70	MP0005376_homeostasis/metabolism_phenot	0.84750451
71	MP0009333_abnormal_splenocyte_physiolog	0.83996362
72	MP0002163_abnormal_gland_morphology	0.82352310
73	MP0005025_abnormal_response_to	0.82065616
74	MP0005084_abnormal_gallbladder_morpholo	0.81240736
75	MP0002078_abnormal_glucose_homeostasis	0.79371023
76	MP0002229_neurodegeneration	0.79201360
77	MP0004130_abnormal_muscle_cell	0.79190816
78	MP0009765_abnormal_xenobiotic_induced	0.79173632
79	MP0005535_abnormal_body_temperature	0.78930430
80	MP0002693_abnormal_pancreas_physiology	0.78222469
81	MP0000678_abnormal_parathyroid_gland	0.76701996
82	MP0003880_abnormal_central_pattern	0.75464997
83	MP0002971_abnormal_brown_adipose	0.75342405
84	MP0005220_abnormal_exocrine_pancreas	0.74719054
85	MP0003705_abnormal_hypodermis_morpholog	0.72166957
86	MP0005334_abnormal_fat_pad	0.72106981
87	MP0001756_abnormal_urination	0.69940835
88	MP0001881_abnormal_mammary_gland	0.69689337
89	MP0002332_abnormal_exercise_endurance	0.68919318
90	MP0005266_abnormal_metabolism	0.68216160
91	MP0001661_extended_life_span	0.66718826
92	MP0001727_abnormal_embryo_implantation	0.65483630
93	MP0003329_amyloid_beta_deposits	0.64352198
94	MP0003724_increased_susceptibility_to	0.63528431
95	MP0001873_stomach_inflammation	0.63259537
96	MP0006035_abnormal_mitochondrial_morpho	0.62396848
97	MP0000538_abnormal_urinary_bladder	0.62319985
98	MP0000639_abnormal_adrenal_gland	0.61025746
99	MP0002837_dystrophic_cardiac_calcinosis	0.57189940
100	MP0004782_abnormal_surfactant_physiolog	0.55546262
101	MP0002822_catalepsy	0.53993787
102	MP0002136_abnormal_kidney_physiology	0.53327593
103	MP0003638_abnormal_response/metabolism_	0.52567638
104	MP0005448_abnormal_energy_balance	0.52381185
105	MP0005464_abnormal_platelet_physiology	0.51533614
106	MP0003075_altered_response_to	0.48372322
107	MP0005666_abnormal_adipose_tissue	0.47701143
108	MP0005058_abnormal_lysosome_morphology	0.46641678
109	MP0008874_decreased_physiological_sensi	0.45326592
110	MP0005395_other_phenotype	0.45057729
111	MP0000230_abnormal_systemic_arterial	0.45030661
112	MP0003953_abnormal_hormone_level	0.44291066
113	MP0008873_increased_physiological_sensi	0.43989627
114	MP0009053_abnormal_anal_canal	0.43955354
115	MP0004043_abnormal_pH_regulation	0.42498763
116	MP0008872_abnormal_physiological_respon	0.41043734
117	MP0003718_maternal_effect	0.40220211
118	MP0004381_abnormal_hair_follicle	0.39732684
119	MP0003436_decreased_susceptibility_to	0.39447486
120	MP0005166_decreased_susceptibility_to	0.39141161
121	MP0006082_CNS_inflammation	0.38145320
122	MP0002132_abnormal_respiratory_system	0.37275957
123	MP0002928_abnormal_bile_duct	0.35465853
124	MP0000249_abnormal_blood_vessel	0.34162626
125	MP0004883_abnormal_blood_vessel	0.33041292
126	MP0005164_abnormal_response_to	0.32764463
127	MP0002796_impaired_skin_barrier	0.32458332
128	MP0009115_abnormal_fat_cell	0.32132346
129	MP0004147_increased_porphyrin_level	0.30987552
130	MP0001853_heart_inflammation	0.29995562
131	MP0002168_other_aberrant_phenotype	0.29817102
132	MP0002970_abnormal_white_adipose	0.29761753
133	MP0001845_abnormal_inflammatory_respons	0.29519871
134	MP0001765_abnormal_ion_homeostasis	0.29310273
135	MP0002295_abnormal_pulmonary_circulatio	0.28936745
136	MP0002090_abnormal_vision	0.27298965
137	MP0005595_abnormal_vascular_smooth	0.27078164
138	MP0000579_abnormal_nail_morphology	0.25800356

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.40930915
2	Intrahepatic cholestasis (HP:0001406)	6.93848553
3	Deep venous thrombosis (HP:0002625)	6.83226406
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.29837815
5	Prolonged partial thromboplastin time (HP:0003645)	6.24090602
6	Xanthomatosis (HP:0000991)	6.00125308
7	Hypobetalipoproteinemia (HP:0003563)	5.97696094
8	Hyperlipoproteinemia (HP:0010980)	5.51576006
9	Complement deficiency (HP:0004431)	4.99523921
10	Hepatocellular necrosis (HP:0001404)	4.90892671
11	Abnormal mitochondria in muscle tissue (HP:0008316)	4.86454662
12	Hepatic necrosis (HP:0002605)	4.68918891
13	Mitochondrial inheritance (HP:0001427)	4.63726945
14	Joint hemorrhage (HP:0005261)	4.62513713
15	Acute necrotizing encephalopathy (HP:0006965)	4.59975978
16	Hyperammonemia (HP:0001987)	4.58286028
17	Hypolipoproteinemia (HP:0010981)	4.47834673
18	Hyperglycinemia (HP:0002154)	4.40638175
19	Ketosis (HP:0001946)	4.32751323
20	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.25728928
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.25728928
22	Abnormality of methionine metabolism (HP:0010901)	4.23268535
23	Acute encephalopathy (HP:0006846)	4.23020048
24	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.16492424
25	Epidermoid cyst (HP:0200040)	4.16148567
26	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.15543947
27	Hyperglycinuria (HP:0003108)	4.13466032
28	Abnormality of the common coagulation pathway (HP:0010990)	4.11760559
29	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.10796475
30	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.10519240
31	Abnormality of serine family amino acid metabolism (HP:0010894)	4.07737778
32	Abnormality of glycine metabolism (HP:0010895)	4.07737778
33	Fat malabsorption (HP:0002630)	4.01156508
34	Increased CSF lactate (HP:0002490)	3.97494044
35	Hypoalphalipoproteinemia (HP:0003233)	3.93506859
36	Increased intramyocellular lipid droplets (HP:0012240)	3.92840248
37	Hypoglycemic coma (HP:0001325)	3.92137984
38	Progressive macrocephaly (HP:0004481)	3.75679868
39	Increased muscle lipid content (HP:0009058)	3.72444612
40	Abnormality of fatty-acid metabolism (HP:0004359)	3.66332270
41	Abnormality of the intrinsic pathway (HP:0010989)	3.64033815
42	Abnormality of complement system (HP:0005339)	3.62323785
43	Abnormality of pyrimidine metabolism (HP:0004353)	3.61184965
44	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.54672941
45	Conjugated hyperbilirubinemia (HP:0002908)	3.48374853
46	Hypercholesterolemia (HP:0003124)	3.42320716
47	Prolonged neonatal jaundice (HP:0006579)	3.41610715
48	Hyperbilirubinemia (HP:0002904)	3.26185670
49	Lactic acidosis (HP:0003128)	3.24776165
50	Ketoacidosis (HP:0001993)	3.20034879
51	Steatorrhea (HP:0002570)	3.16215872
52	Delayed CNS myelination (HP:0002188)	3.14769913
53	Abnormality of serum amino acid levels (HP:0003112)	3.13715280
54	Renal Fanconi syndrome (HP:0001994)	3.08227758
55	Respiratory failure (HP:0002878)	3.08176042
56	Abnormality of glycolipid metabolism (HP:0010969)	3.05442917
57	Abnormality of liposaccharide metabolism (HP:0010968)	3.05442917
58	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.05442917
59	Abnormality of nucleobase metabolism (HP:0010932)	3.02349724
60	Dicarboxylic aciduria (HP:0003215)	2.98443991
61	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.98443991
62	Type I transferrin isoform profile (HP:0003642)	2.95187366
63	Exercise intolerance (HP:0003546)	2.92228140
64	Ragged-red muscle fibers (HP:0003200)	2.88370153
65	Metabolic acidosis (HP:0001942)	2.88337242
66	Lethargy (HP:0001254)	2.86052897
67	Increased serum lactate (HP:0002151)	2.85323045
68	Lipid accumulation in hepatocytes (HP:0006561)	2.85272521
69	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.84895369
70	Increased hepatocellular lipid droplets (HP:0006565)	2.83425168
71	Hepatocellular carcinoma (HP:0001402)	2.77789606
72	Cerebral edema (HP:0002181)	2.76656806
73	Spontaneous abortion (HP:0005268)	2.75259922
74	Abnormality of purine metabolism (HP:0004352)	2.72932103
75	Systemic lupus erythematosus (HP:0002725)	2.69987866
76	Vascular calcification (HP:0004934)	2.67982191
77	Vacuolated lymphocytes (HP:0001922)	2.66915042
78	Myocardial infarction (HP:0001658)	2.63682438
79	Skin nodule (HP:0200036)	2.62047681
80	Abnormality of glycolysis (HP:0004366)	2.58989708
81	Emotional lability (HP:0000712)	2.58291908
82	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.57730872
83	Increased serum pyruvate (HP:0003542)	2.55299776
84	Gout (HP:0001997)	2.55148381
85	Generalized aminoaciduria (HP:0002909)	2.50018180
86	CNS demyelination (HP:0007305)	2.48981038
87	Hypochromic microcytic anemia (HP:0004840)	2.45820131
88	Testicular atrophy (HP:0000029)	2.45586639
89	Abnormal gallbladder morphology (HP:0012437)	2.42386590
90	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.40942401
91	Abnormal protein N-linked glycosylation (HP:0012347)	2.40942401
92	Abnormal protein glycosylation (HP:0012346)	2.40942401
93	Abnormal glycosylation (HP:0012345)	2.40942401
94	Reduced antithrombin III activity (HP:0001976)	2.39207583
95	Myokymia (HP:0002411)	2.38311749
96	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.36614679
97	Cholecystitis (HP:0001082)	2.36597163
98	Abnormal gallbladder physiology (HP:0012438)	2.36597163
99	Hypoglycemic seizures (HP:0002173)	2.35402205
100	Cardiovascular calcification (HP:0011915)	2.35311324
101	Irritability (HP:0000737)	2.35199734
102	Cholelithiasis (HP:0001081)	2.33707589
103	Vomiting (HP:0002013)	2.31782971
104	Increased cerebral lipofuscin (HP:0011813)	2.30684919
105	Neonatal onset (HP:0003623)	2.30382509
106	Amyloidosis (HP:0011034)	2.30297059
107	Glomerulonephritis (HP:0000099)	2.27514775
108	Microretrognathia (HP:0000308)	2.25615312
109	Brushfield spots (HP:0001088)	2.24636827
110	Acanthocytosis (HP:0001927)	2.24023900
111	Microvesicular hepatic steatosis (HP:0001414)	2.23036690
112	Malnutrition (HP:0004395)	2.22946340
113	Pancreatitis (HP:0001733)	2.21423788
114	Spastic diplegia (HP:0001264)	2.19993295
115	Cerebral palsy (HP:0100021)	2.19542240
116	Mitral stenosis (HP:0001718)	2.19042264
117	Progressive microcephaly (HP:0000253)	2.18057372
118	Recurrent gram-negative bacterial infections (HP:0005420)	2.17996334
119	Opisthotonus (HP:0002179)	2.16461713
120	Late onset (HP:0003584)	2.15914119
121	Sensorimotor neuropathy (HP:0007141)	2.15046784
122	Progressive neurologic deterioration (HP:0002344)	2.14581857
123	Loss of speech (HP:0002371)	2.12522931
124	Hypokinesia (HP:0002375)	2.09477879
125	Dysostosis multiplex (HP:0000943)	2.09360763
126	Enlarged kidneys (HP:0000105)	2.08926393
127	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08421590
128	Proximal tubulopathy (HP:0000114)	2.06725420
129	Hyperthyroidism (HP:0000836)	2.06069232
130	Renal cortical cysts (HP:0000803)	2.03810569
131	Menorrhagia (HP:0000132)	2.03235792
132	J-shaped sella turcica (HP:0002680)	2.02900101
133	Alkalosis (HP:0001948)	2.02567728
134	Gingival bleeding (HP:0000225)	2.02395122
135	Abnormality of urine glucose concentration (HP:0011016)	2.01203201
136	Glycosuria (HP:0003076)	2.01203201
137	Abnormality of proline metabolism (HP:0010907)	1.99771139
138	Hydroxyprolinuria (HP:0003080)	1.99771139
139	Leukodystrophy (HP:0002415)	1.99341557
140	Hyperphosphaturia (HP:0003109)	1.97426873
141	Abnormality of the gallbladder (HP:0005264)	1.97060509
142	Esophageal varix (HP:0002040)	1.95915860
143	Exertional dyspnea (HP:0002875)	1.95429530
144	Rhabdomyolysis (HP:0003201)	1.95286639
145	Hemorrhage of the eye (HP:0011885)	1.95284371
146	3-Methylglutaconic aciduria (HP:0003535)	1.95107811
147	Rickets (HP:0002748)	1.95021542
148	Degeneration of anterior horn cells (HP:0002398)	1.94463647
149	Abnormality of the anterior horn cell (HP:0006802)	1.94463647
150	Thrombophlebitis (HP:0004418)	1.91666399
151	Optic disc pallor (HP:0000543)	1.91293260
152	Methylmalonic aciduria (HP:0012120)	1.91131881
153	Elevated hepatic transaminases (HP:0002910)	1.91113067
154	Hyperinsulinemic hypoglycemia (HP:0000825)	1.90219615
155	Increased serum ferritin (HP:0003281)	1.89784635
156	Abnormality of vitamin metabolism (HP:0100508)	1.89635275
157	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.89065242
158	Progressive muscle weakness (HP:0003323)	1.86038563
159	Petechiae (HP:0000967)	1.85101234
160	Hypophosphatemic rickets (HP:0004912)	1.84454574
161	Abnormal cartilage morphology (HP:0002763)	1.84066974
162	Abnormality of iron homeostasis (HP:0011031)	1.82011260
163	Abnormal enzyme/coenzyme activity (HP:0012379)	1.81918915
164	Abnormality of transition element cation homeostasis (HP:0011030)	1.79795985
165	Gliosis (HP:0002171)	1.79689333
166	Nausea (HP:0002018)	1.77633902
167	Abnormality of polysaccharide metabolism (HP:0011012)	1.76849329
168	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.76849329
169	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.76849329
170	Cerebral hypomyelination (HP:0006808)	1.76421460
171	Hepatosplenomegaly (HP:0001433)	1.74351125

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	7.91846780
2	VRK2	5.24308047
3	ERN1	4.09745627
4	SIK1	3.96040353
5	FGFR4	3.94637264
6	TESK1	3.54361341
7	TESK2	3.37446811
8	INSRR	3.12579906
9	PIM2	2.87933835
10	TAOK3	2.70186335
11	MAPKAPK3	2.61014542
12	ARAF	2.41895224
13	ERBB4	2.39571752
14	LIMK1	2.24843356
15	MST1R	2.20101642
16	EPHA2	2.02014606
17	SCYL2	1.96187078
18	MAP2K4	1.86100982
19	FLT3	1.84005009
20	PIK3CG	1.77291967
21	ABL2	1.75503621
22	DAPK1	1.75195365
23	MAP3K12	1.66957129
24	PINK1	1.65700164
25	MUSK	1.64377837
26	MAP4K2	1.57612926
27	MAPK11	1.56948724
28	MAP2K3	1.54472368
29	LATS1	1.54219597
30	NME1	1.52813997
31	TYK2	1.52305041
32	MAP3K3	1.46888824
33	PKN2	1.46259745
34	TIE1	1.45017197
35	TRIB3	1.39508336
36	NEK9	1.30924347
37	KDR	1.28267130
38	MAPK15	1.26917048
39	EPHB1	1.25108938
40	DAPK2	1.18289446
41	FRK	1.16929291
42	PRKAA2	1.14835208
43	LMTK2	1.09341847
44	PTK6	1.06452214
45	TBK1	1.05066716
46	RPS6KB2	1.04361931
47	SMG1	1.02238188
48	MAP3K7	1.02061455
49	TNK2	1.00667225
50	JAK2	0.99589884
51	IRAK3	0.99206653
52	MET	0.96877911
53	STK38L	0.94895024
54	LRRK2	0.94365283
55	PRKCI	0.94291964
56	MAP3K14	0.93981970
57	VRK1	0.92735273
58	MAPK4	0.91183138
59	EPHA3	0.91168618
60	FGFR2	0.90617557
61	ILK	0.88311946
62	DAPK3	0.86726596
63	CSNK1A1L	0.85960859
64	IKBKB	0.83504273
65	PBK	0.82484245
66	CAMK2G	0.81589643
67	PRKCZ	0.80444432
68	ERBB2	0.80292090
69	MYLK	0.79224439
70	MAP3K11	0.79177959
71	PHKG2	0.74225238
72	PHKG1	0.74225238
73	KIT	0.72475373
74	JAK1	0.71152111
75	PRKACG	0.70520311
76	MAP4K1	0.70479844
77	WNK4	0.69638436
78	MAP2K6	0.69222436
79	MAPK12	0.68379236
80	GRK6	0.68237164
81	PAK4	0.67305224
82	CAMK2D	0.66985477
83	GRK5	0.66768654
84	GSK3A	0.66596441
85	TGFBR2	0.65722964
86	NUAK1	0.64108803
87	NME2	0.63837601
88	PDPK1	0.63309554
89	SGK494	0.62885094
90	SGK223	0.62885094
91	GRK1	0.61829328
92	AURKA	0.59562635
93	MAPKAPK5	0.59458623
94	CAMK1D	0.59344872
95	IKBKE	0.59219710
96	STK16	0.58708852
97	DYRK1B	0.58226845
98	STK39	0.57431363
99	PKN1	0.57247641
100	MST4	0.56549736
101	PDK4	0.56325909
102	PDK3	0.56325909
103	CSNK1G1	0.56159282
104	CSK	0.55332801
105	BUB1	0.54934320
106	TAOK2	0.54775161
107	PRKCQ	0.54432468
108	RPS6KA5	0.53944393
109	IRAK1	0.53336514
110	SGK3	0.52971806
111	CSF1R	0.52213437
112	PRKAA1	0.51275866
113	SGK2	0.50863953
114	BRAF	0.50174975
115	OXSR1	0.50168266
116	SRPK1	0.50079124
117	PIK3CA	0.48952277
118	MAPK7	0.47253438
119	EPHA4	0.46671859
120	CDK19	0.45280838
121	CSNK1G3	0.45203867
122	MAP3K1	0.43730434
123	MAP2K2	0.43167359
124	TLK1	0.41684271
125	MAP2K7	0.41090333
126	IRAK2	0.39669840
127	PRKD3	0.39461754
128	MAP2K1	0.38748364
129	CSNK2A1	0.38725747
130	CAMK2B	0.38607987
131	CSNK1A1	0.38570744
132	TAOK1	0.37697757
133	IGF1R	0.37410355
134	DYRK2	0.36798452
135	CDK6	0.36646573
136	CSNK2A2	0.36579915
137	EIF2AK1	0.35857300
138	PAK1	0.35731779
139	PAK6	0.33914302
140	EPHB2	0.33162456
141	CSNK1G2	0.33161075
142	MAP3K6	0.31220580
143	PRKCD	0.30228265
144	PRKCG	0.30197574
145	PRKD1	0.29824948
146	MINK1	0.29681554
147	SIK3	0.29677617
148	CCNB1	0.29361667
149	PRPF4B	0.29326108
150	PRKCA	0.28792331
151	PDK1	0.28429314
152	FER	0.26585916
153	PRKACA	0.26001446
154	PTK2	0.25721403
155	PDK2	0.25645709
156	ADRBK2	0.25564549
157	ICK	0.25373294
158	GRK7	0.25242913
159	AKT2	0.23699208
160	EGFR	0.23645747
161	CAMK4	0.22543827
162	HIPK2	0.21227656

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.30464634
2	Proteasome_Homo sapiens_hsa03050	3.49796064
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.30856104
4	Nitrogen metabolism_Homo sapiens_hsa00910	3.08424975
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.01122044
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.81087933
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.74675958
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.63410354
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.62886691
10	Complement and coagulation cascades_Homo sapiens_hsa04610	2.56219004
11	Fatty acid degradation_Homo sapiens_hsa00071	2.54478282
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.52758642
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.50359541
14	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.33684649
15	Ribosome_Homo sapiens_hsa03010	2.25090864
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.24099589
17	Peroxisome_Homo sapiens_hsa04146	2.19737088
18	Butanoate metabolism_Homo sapiens_hsa00650	2.19604786
19	Propanoate metabolism_Homo sapiens_hsa00640	2.10723579
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.02577614
21	Chemical carcinogenesis_Homo sapiens_hsa05204	2.02009205
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.98541373
23	Histidine metabolism_Homo sapiens_hsa00340	1.92610017
24	Fatty acid metabolism_Homo sapiens_hsa01212	1.88831957
25	PPAR signaling pathway_Homo sapiens_hsa03320	1.87999384
26	Huntingtons disease_Homo sapiens_hsa05016	1.83613435
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75524991
28	beta-Alanine metabolism_Homo sapiens_hsa00410	1.73441283
29	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.72950161
30	Retinol metabolism_Homo sapiens_hsa00830	1.72209757
31	Caffeine metabolism_Homo sapiens_hsa00232	1.70185237
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.62440918
33	Sulfur metabolism_Homo sapiens_hsa00920	1.62182087
34	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.61414872
35	Fatty acid elongation_Homo sapiens_hsa00062	1.60759783
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57822723
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.56718446
38	Phenylalanine metabolism_Homo sapiens_hsa00360	1.55263781
39	Base excision repair_Homo sapiens_hsa03410	1.55208534
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.54803035
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.52116702
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.51352451
43	Pyruvate metabolism_Homo sapiens_hsa00620	1.49272392
44	Tyrosine metabolism_Homo sapiens_hsa00350	1.48528999
45	RNA polymerase_Homo sapiens_hsa03020	1.43461680
46	Bile secretion_Homo sapiens_hsa04976	1.38561624
47	Steroid biosynthesis_Homo sapiens_hsa00100	1.34747392
48	Folate biosynthesis_Homo sapiens_hsa00790	1.32906205
49	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31413296
50	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.29621196
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.28503093
52	Carbon metabolism_Homo sapiens_hsa01200	1.18275490
53	Collecting duct acid secretion_Homo sapiens_hsa04966	1.17496674
54	Fat digestion and absorption_Homo sapiens_hsa04975	1.16146683
55	ABC transporters_Homo sapiens_hsa02010	1.14893966
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13410913
57	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.13309506
58	Vibrio cholerae infection_Homo sapiens_hsa05110	1.12664960
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.09398675
60	Sulfur relay system_Homo sapiens_hsa04122	1.06803844
61	Arginine and proline metabolism_Homo sapiens_hsa00330	1.03741140
62	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.00020429
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.98036085
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.96421016
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.94717986
66	DNA replication_Homo sapiens_hsa03030	0.93969637
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.91607388
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90784813
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87794822
70	Glutathione metabolism_Homo sapiens_hsa00480	0.84118765
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.83431634
72	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.81843963
73	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.81705000
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.81233141
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72829477
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71694994
77	Homologous recombination_Homo sapiens_hsa03440	0.69125291
78	Purine metabolism_Homo sapiens_hsa00230	0.67317620
79	Lysine degradation_Homo sapiens_hsa00310	0.66552747
80	Mismatch repair_Homo sapiens_hsa03430	0.64248463
81	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.64035689
82	One carbon pool by folate_Homo sapiens_hsa00670	0.63511350
83	Pentose phosphate pathway_Homo sapiens_hsa00030	0.60385112
84	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.56503472
85	Metabolic pathways_Homo sapiens_hsa01100	0.56009029
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51237741
87	Asthma_Homo sapiens_hsa05310	0.45531686
88	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.45478742
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.45300997
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.42776902
91	Sphingolipid metabolism_Homo sapiens_hsa00600	0.39099558
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37607709
93	Linoleic acid metabolism_Homo sapiens_hsa00591	0.35317013
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34329843
95	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.31213767
96	Prion diseases_Homo sapiens_hsa05020	0.30954068
97	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.30891053
98	Galactose metabolism_Homo sapiens_hsa00052	0.30669889
99	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.30495851
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29910351
101	Mineral absorption_Homo sapiens_hsa04978	0.27598260
102	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.23857804
103	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.20393005
104	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.16209316
105	Insulin resistance_Homo sapiens_hsa04931	0.15351136
106	Oxidative phosphorylation_Homo sapiens_hsa00190	0.06473966
107	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.03106367
108	Glucagon signaling pathway_Homo sapiens_hsa04922	0.02502056
109	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.00276638
110	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.2155349
111	Other glycan degradation_Homo sapiens_hsa00511	-0.2090501
112	Lysosome_Homo sapiens_hsa04142	-0.1913760
113	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1908774
114	Hepatitis C_Homo sapiens_hsa05160	-0.1880889
115	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.1751587
116	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1698190
117	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1600161
118	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1556058
119	African trypanosomiasis_Homo sapiens_hsa05143	-0.1405831
120	Protein export_Homo sapiens_hsa03060	-0.1173093
121	Alzheimers disease_Homo sapiens_hsa05010	-0.0931473
122	Ether lipid metabolism_Homo sapiens_hsa00565	-0.0790495
123	Regulation of autophagy_Homo sapiens_hsa04140	-0.0752720
124	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.0680186
125	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0535044
126	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0371464
127	Parkinsons disease_Homo sapiens_hsa05012	-0.0315413

TMEM205

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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