TMEM206

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)7.79563189
2protein maturation by protein folding (GO:0022417)7.16431900
3endocrine pancreas development (GO:0031018)6.78662150
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.42234369
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.34793683
6sequestering of metal ion (GO:0051238)6.10742096
7regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.91008853
8peptide hormone processing (GO:0016486)5.75912470
9COPII vesicle coating (GO:0048208)5.72754098
10protein retention in ER lumen (GO:0006621)5.43254033
11regulation of type B pancreatic cell apoptotic process (GO:2000674)4.99477118
12negative regulation of glycoprotein biosynthetic process (GO:0010561)4.73141742
13vesicle coating (GO:0006901)4.68897464
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.68671938
15ER overload response (GO:0006983)4.61464229
16positive regulation of nuclease activity (GO:0032075)4.59943721
17positive regulation of insulin secretion (GO:0032024)4.59102668
18glandular epithelial cell differentiation (GO:0002067)4.58274621
19type B pancreatic cell development (GO:0003323)4.44769783
20exocrine pancreas development (GO:0031017)4.33001034
21insulin secretion (GO:0030073)4.31269205
22regulation of nuclease activity (GO:0032069)4.20948944
23negative regulation of phosphoprotein phosphatase activity (GO:0032515)4.16480095
24negative regulation of bone resorption (GO:0045779)4.03181892
25endoplasmic reticulum unfolded protein response (GO:0030968)4.01415678
26cellular response to topologically incorrect protein (GO:0035967)3.98567035
27cellular response to unfolded protein (GO:0034620)3.97529247
28glandular epithelial cell development (GO:0002068)3.97481024
29regulation of insulin secretion (GO:0050796)3.95885638
30protein N-linked glycosylation via asparagine (GO:0018279)3.95661738
31peptidyl-asparagine modification (GO:0018196)3.93022752
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.90867974
33sequestering of actin monomers (GO:0042989)3.85798635
34ER-nucleus signaling pathway (GO:0006984)3.73168268
35cellular zinc ion homeostasis (GO:0006882)3.63053345
36ER to Golgi vesicle-mediated transport (GO:0006888)3.61949165
37protein N-linked glycosylation (GO:0006487)3.60521318
38intra-Golgi vesicle-mediated transport (GO:0006891)3.60299265
39regulation of peptide hormone secretion (GO:0090276)3.55965907
40replication fork processing (GO:0031297)3.53616425
41nitric oxide mediated signal transduction (GO:0007263)3.51376647
42positive regulation of peptide hormone secretion (GO:0090277)3.50435113
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.48689493
44regulation of peptide secretion (GO:0002791)3.47908650
45negative regulation of glycoprotein metabolic process (GO:1903019)3.47695947
46negative regulation of insulin secretion (GO:0046676)3.45551988
47negative regulation of norepinephrine secretion (GO:0010700)3.45169143
48chaperone-mediated protein transport (GO:0072321)3.43962178
49regulation of glucocorticoid secretion (GO:2000849)3.43180014
50proteasome assembly (GO:0043248)3.40140866
51presynaptic membrane assembly (GO:0097105)3.36819507
52positive regulation of peptide secretion (GO:0002793)3.32420958
53resolution of meiotic recombination intermediates (GO:0000712)3.29593240
54nucleoside diphosphate catabolic process (GO:0009134)3.28907903
55platelet dense granule organization (GO:0060155)3.26975924
56CENP-A containing nucleosome assembly (GO:0034080)3.23992378
57pseudouridine synthesis (GO:0001522)3.23216960
58L-alpha-amino acid transmembrane transport (GO:1902475)3.22465811
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.21630327
60NADH dehydrogenase complex assembly (GO:0010257)3.21630327
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21630327
62chromatin remodeling at centromere (GO:0031055)3.21551295
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21135555
64response to endoplasmic reticulum stress (GO:0034976)3.21121352
65DNA ligation (GO:0006266)3.20315269
66regulation of glucokinase activity (GO:0033131)3.20000426
67regulation of hexokinase activity (GO:1903299)3.20000426
68spermatid nucleus differentiation (GO:0007289)3.16014756
69regulation of hormone secretion (GO:0046883)3.12612296
70GDP-mannose metabolic process (GO:0019673)3.12190472
71interleukin-1-mediated signaling pathway (GO:0070498)3.12173612
72negative regulation of bone remodeling (GO:0046851)3.11531865
73epithelial cell fate commitment (GO:0072148)3.11338424
74centriole replication (GO:0007099)3.09487657
75anterograde synaptic vesicle transport (GO:0048490)3.08832978
76regulation of mitochondrial translation (GO:0070129)3.08396234
77detection of calcium ion (GO:0005513)3.05990984
78mitochondrial respiratory chain complex assembly (GO:0033108)3.04409800
79protein neddylation (GO:0045116)3.04208955
80Golgi organization (GO:0007030)3.04187275
81ganglioside metabolic process (GO:0001573)3.04004015
82cellular response to vitamin D (GO:0071305)3.02956942
83protein complex biogenesis (GO:0070271)3.02674290
84negative regulation of peptide hormone secretion (GO:0090278)3.02103992
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99561796
86neural tube formation (GO:0001841)2.99267433
87Golgi vesicle transport (GO:0048193)2.98792420
88G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.98445715
89DNA damage response, detection of DNA damage (GO:0042769)2.98436258
90viral protein processing (GO:0019082)2.96311556
91presynaptic membrane organization (GO:0097090)2.96126924
92negative regulation of peptide secretion (GO:0002792)2.94595244
93cell wall macromolecule catabolic process (GO:0016998)2.93900976
94kinetochore assembly (GO:0051382)2.93644048
95zinc ion homeostasis (GO:0055069)2.93023872
96response to unfolded protein (GO:0006986)2.91733788
97astrocyte differentiation (GO:0048708)2.91472372
98peptide hormone secretion (GO:0030072)2.91239653
99response to topologically incorrect protein (GO:0035966)2.90927313
100glycosphingolipid catabolic process (GO:0046479)2.90442091
101regulation of peptide transport (GO:0090087)2.90248499
102positive regulation of hormone secretion (GO:0046887)2.88337356
103glycoside metabolic process (GO:0016137)2.87285000
104antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86849404
105antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86849404
106respiratory chain complex IV assembly (GO:0008535)2.86799956
107peptide secretion (GO:0002790)2.85901895
108response to hexose (GO:0009746)2.85377163
109virion assembly (GO:0019068)2.84861519
110pteridine-containing compound biosynthetic process (GO:0042559)2.84061248
111negative regulation of catecholamine secretion (GO:0033604)2.82496679
112negative regulation of DNA-dependent DNA replication (GO:2000104)2.81976611
113response to glucose (GO:0009749)2.79514116
114protein localization to cilium (GO:0061512)2.79421141
115DNA topological change (GO:0006265)2.78969357
116response to misfolded protein (GO:0051788)2.77620465
117neuron cell-cell adhesion (GO:0007158)2.76767855
118negative regulation of calcium ion transport into cytosol (GO:0010523)2.76599744
119lactate metabolic process (GO:0006089)2.75868305
120eosinophil chemotaxis (GO:0048245)2.75630544
121folic acid-containing compound biosynthetic process (GO:0009396)2.74143866
122pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.74125397
123meiosis I (GO:0007127)2.73666222
124mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73473687
125negative regulation of tissue remodeling (GO:0034104)2.73469710
126peptide catabolic process (GO:0043171)2.71901606
127regulation of oxidative phosphorylation (GO:0002082)2.71871484
128response to monosaccharide (GO:0034284)2.70045826
129columnar/cuboidal epithelial cell development (GO:0002066)2.68819468
130mannosylation (GO:0097502)2.68736591
131glycolipid catabolic process (GO:0019377)2.68565229
132iron-sulfur cluster assembly (GO:0016226)2.66017992
133metallo-sulfur cluster assembly (GO:0031163)2.66017992
134regulation of interferon-beta biosynthetic process (GO:0045357)2.64635476
135intraciliary transport (GO:0042073)2.64565398
136DNA double-strand break processing (GO:0000729)2.64234290
137maintenance of protein localization in organelle (GO:0072595)2.63723637
138macroautophagy (GO:0016236)2.62292858
139DNA catabolic process, exonucleolytic (GO:0000738)2.61872324
140cullin deneddylation (GO:0010388)2.61355919
141negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60910057
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59862048
143pyrimidine nucleotide catabolic process (GO:0006244)2.59517339
144postsynaptic membrane organization (GO:0001941)2.58756848
145deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.58498739
146intracellular pH reduction (GO:0051452)2.58421899
147kinetochore organization (GO:0051383)2.58324056
148positive regulation of mast cell degranulation (GO:0043306)2.57543190
149positive regulation of mast cell activation involved in immune response (GO:0033008)2.57543190
150histone exchange (GO:0043486)2.56956481
151nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.53871860
152cytochrome complex assembly (GO:0017004)2.53531189
153positive regulation of mitochondrial fission (GO:0090141)2.52079069
154protein K11-linked ubiquitination (GO:0070979)2.51753330
155rRNA modification (GO:0000154)2.49623955
156regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.49523044
157nonmotile primary cilium assembly (GO:0035058)2.49199017
158anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.47898539
159purine nucleobase biosynthetic process (GO:0009113)2.46804508
160establishment of integrated proviral latency (GO:0075713)2.46575275
161positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.45589927
162base-excision repair, AP site formation (GO:0006285)2.44714057
163positive regulation of oligodendrocyte differentiation (GO:0048714)2.44206585
164ubiquinone metabolic process (GO:0006743)2.44021861
165energy coupled proton transport, down electrochemical gradient (GO:0015985)2.42835150
166ATP synthesis coupled proton transport (GO:0015986)2.42835150
167spliceosomal snRNP assembly (GO:0000387)2.42650709
168establishment of viral latency (GO:0019043)2.42228130
169transcription from mitochondrial promoter (GO:0006390)2.41672802
170DNA replication-dependent nucleosome assembly (GO:0006335)2.41609078
171DNA replication-dependent nucleosome organization (GO:0034723)2.41609078
172DNA replication-independent nucleosome assembly (GO:0006336)2.39481677
173DNA replication-independent nucleosome organization (GO:0034724)2.39481677
174deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.38691446
175negative regulation of ligase activity (GO:0051352)2.38323461
176negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.38323461
177positive regulation of mast cell activation (GO:0033005)2.38276954
178negative regulation of mast cell activation (GO:0033004)2.37992107
179protein targeting to mitochondrion (GO:0006626)2.37832393
180ubiquinone biosynthetic process (GO:0006744)2.37750161
181male meiosis I (GO:0007141)2.37630215
182protein localization to mitochondrion (GO:0070585)2.37370729
183Sertoli cell development (GO:0060009)2.37367762
184exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36863923
185pyrimidine nucleobase catabolic process (GO:0006208)2.36294991
186histone mRNA metabolic process (GO:0008334)2.35297608
187mitochondrial RNA metabolic process (GO:0000959)2.34991824
188prenylation (GO:0097354)2.34736356
189protein prenylation (GO:0018342)2.34736356
190anterograde axon cargo transport (GO:0008089)2.32540167
191establishment of protein localization to mitochondrion (GO:0072655)2.31604655
192deoxyribose phosphate catabolic process (GO:0046386)2.31551043
193cell wall macromolecule metabolic process (GO:0044036)2.31411213
194single strand break repair (GO:0000012)2.31144667
195spindle checkpoint (GO:0031577)2.30886463
196protein deneddylation (GO:0000338)2.30250764
197regulation of cilium movement (GO:0003352)2.30079908
198Golgi transport vesicle coating (GO:0048200)10.9872455
199COPI coating of Golgi vesicle (GO:0048205)10.9872455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.18057464
2GATA1_22025678_ChIP-Seq_K562_Human4.71863582
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.07866819
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.66973345
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.57806204
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90936872
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85906351
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81622135
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77153633
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.76554368
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62814781
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51008881
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49324455
14TFEB_21752829_ChIP-Seq_HELA_Human2.41966180
15* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.38972737
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38613979
17ERG_20887958_ChIP-Seq_HPC-7_Mouse2.34495212
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32454098
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21400797
20MYC_18940864_ChIP-ChIP_HL60_Human2.19989590
21FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.19509810
22* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14606991
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14153553
24* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14043686
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11574275
26ZNF274_21170338_ChIP-Seq_K562_Hela2.09118450
27* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse2.01760652
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00284720
29CIITA_25753668_ChIP-Seq_RAJI_Human2.00098363
30* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97537098
31EWS_26573619_Chip-Seq_HEK293_Human1.94242663
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93863294
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91610025
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.91576187
35SCL_19346495_ChIP-Seq_HPC-7_Human1.91537695
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.90832884
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.88371173
38* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86971667
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85210743
40VDR_23849224_ChIP-Seq_CD4+_Human1.83670468
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79693832
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79322070
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79160293
44* SPI1_23547873_ChIP-Seq_NB4_Human1.77307108
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.75950530
46* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75938106
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.72380347
48TTF2_22483619_ChIP-Seq_HELA_Human1.69921763
49MYC_22102868_ChIP-Seq_BL_Human1.69591435
50TAF15_26573619_Chip-Seq_HEK293_Human1.69148535
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.68838110
52IRF1_19129219_ChIP-ChIP_H3396_Human1.66618597
53FOXP3_21729870_ChIP-Seq_TREG_Human1.61399249
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59595739
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.58421955
56* GABP_19822575_ChIP-Seq_HepG2_Human1.57225804
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54470891
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48536472
59ELK1_19687146_ChIP-ChIP_HELA_Human1.47716616
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47338631
61VDR_24763502_ChIP-Seq_THP-1_Human1.47108343
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46934632
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.46396903
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44394762
65GATA3_27048872_Chip-Seq_THYMUS_Human1.44015279
66VDR_21846776_ChIP-Seq_THP-1_Human1.43080492
67* SPI1_23127762_ChIP-Seq_K562_Human1.41933976
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41918587
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.41707387
70MYB_26560356_Chip-Seq_TH2_Human1.41543972
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39717142
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39366198
73DCP1A_22483619_ChIP-Seq_HELA_Human1.37165336
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36436766
75E2F7_22180533_ChIP-Seq_HELA_Human1.34637687
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34455330
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34153875
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32089456
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32085997
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32084775
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29031766
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28893284
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28439907
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26794081
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26625602
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25573369
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.24618716
88FUS_26573619_Chip-Seq_HEK293_Human1.24616066
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23145644
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19973524
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18362626
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17355061
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17036218
94VDR_22108803_ChIP-Seq_LS180_Human1.17004588
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.16857322
96CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16409535
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15609833
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15364931
99GATA3_26560356_Chip-Seq_TH2_Human1.14650947
100* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14548745
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13772311
102EZH2_22144423_ChIP-Seq_EOC_Human1.09842117
103P300_19829295_ChIP-Seq_ESCs_Human1.09463910
104YY1_21170310_ChIP-Seq_MESCs_Mouse1.08793541
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08292846
106SOX2_16153702_ChIP-ChIP_HESCs_Human1.08238643
107KDM5A_27292631_Chip-Seq_BREAST_Human1.07429089
108ETS1_22383799_ChIP-Seq_G1ME_Mouse1.06953250
109FOXM1_23109430_ChIP-Seq_U2OS_Human1.06665406
110MYB_26560356_Chip-Seq_TH1_Human1.03764302
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03749747
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02900972
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02877713
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02000043
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01959613
116MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01622982
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01137199
118NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00888947
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00622344
120SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00496630
121HTT_18923047_ChIP-ChIP_STHdh_Human1.00316517
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00023764
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99396876
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99236674
125ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98493530
126UTX_26944678_Chip-Seq_JUKART_Human0.98344770
127CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98020098
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97385262
129IGF1R_20145208_ChIP-Seq_DFB_Human0.96309665
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95517978
131* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94199742
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93691514
133RNF2_27304074_Chip-Seq_NSC_Mouse0.93493429
134XRN2_22483619_ChIP-Seq_HELA_Human0.93353268
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93218076
136REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92451824
137* PU_27001747_Chip-Seq_BMDM_Mouse0.92172825
138ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91758848
139MYC_18555785_ChIP-Seq_MESCs_Mouse0.90220395
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90090661
141E2F1_21310950_ChIP-Seq_MCF-7_Human0.89937786
142CBP_20019798_ChIP-Seq_JUKART_Human0.89855888
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89855888
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89752299
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89717142
146STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88662102
147MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87572484
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87517604
149* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86565998
150NOTCH1_21737748_ChIP-Seq_TLL_Human0.86508662
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83150527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.96350088
2MP0003183_abnormal_peptide_metabolism4.39280666
3MP0002693_abnormal_pancreas_physiology4.17500316
4MP0003136_yellow_coat_color3.89055460
5MP0005058_abnormal_lysosome_morphology3.86620603
6MP0003283_abnormal_digestive_organ3.60769109
7MP0001944_abnormal_pancreas_morphology3.57084766
8MP0004043_abnormal_pH_regulation3.55001836
9MP0010386_abnormal_urinary_bladder3.50059569
10MP0008058_abnormal_DNA_repair3.19428844
11MP0003172_abnormal_lysosome_physiology3.18912623
12MP0009780_abnormal_chondrocyte_physiolo3.17676041
13MP0000372_irregular_coat_pigmentation2.98898298
14MP0005379_endocrine/exocrine_gland_phen2.88272377
15MP0002653_abnormal_ependyma_morphology2.85340972
16MP0003195_calcinosis2.81382912
17MP0005220_abnormal_exocrine_pancreas2.73631986
18MP0002909_abnormal_adrenal_gland2.73611717
19MP0000013_abnormal_adipose_tissue2.66788820
20MP0000678_abnormal_parathyroid_gland2.52422176
21MP0001529_abnormal_vocalization2.40512723
22MP0001986_abnormal_taste_sensitivity2.35167430
23MP0003880_abnormal_central_pattern2.34415279
24MP0003300_gastrointestinal_ulcer2.27434808
25MP0005171_absent_coat_pigmentation2.07108627
26MP0002078_abnormal_glucose_homeostasis2.01040273
27MP0002736_abnormal_nociception_after1.98620672
28MP0002638_abnormal_pupillary_reflex1.90048148
29MP0000778_abnormal_nervous_system1.88615922
30MP0005257_abnormal_intraocular_pressure1.88474665
31MP0002928_abnormal_bile_duct1.87891915
32MP0010094_abnormal_chromosome_stability1.87626884
33MP0006292_abnormal_olfactory_placode1.84498874
34MP0006054_spinal_hemorrhage1.83769054
35MP0003121_genomic_imprinting1.82969792
36MP0005310_abnormal_salivary_gland1.77391129
37MP0005646_abnormal_pituitary_gland1.75956019
38MP0004742_abnormal_vestibular_system1.71442614
39MP0004142_abnormal_muscle_tone1.70351862
40MP0006072_abnormal_retinal_apoptosis1.65066433
41MP0006276_abnormal_autonomic_nervous1.64774246
42MP0002735_abnormal_chemical_nociception1.58219785
43MP0005671_abnormal_response_to1.55581734
44MP0001835_abnormal_antigen_presentation1.52846713
45MP0001968_abnormal_touch/_nociception1.51068775
46MP0001984_abnormal_olfaction1.47158615
47MP0000647_abnormal_sebaceous_gland1.45819062
48MP0000003_abnormal_adipose_tissue1.41096942
49MP0006035_abnormal_mitochondrial_morpho1.40520595
50MP0003866_abnormal_defecation1.37725263
51MP0003077_abnormal_cell_cycle1.37537898
52MP0005645_abnormal_hypothalamus_physiol1.36082668
53MP0003122_maternal_imprinting1.35646909
54MP0004133_heterotaxia1.33242912
55MP0004957_abnormal_blastocyst_morpholog1.31525205
56MP0008932_abnormal_embryonic_tissue1.28827701
57MP0002102_abnormal_ear_morphology1.27891693
58MP0008961_abnormal_basal_metabolism1.27455697
59MP0005000_abnormal_immune_tolerance1.25649812
60MP0005499_abnormal_olfactory_system1.25351124
61MP0005394_taste/olfaction_phenotype1.25351124
62MP0008877_abnormal_DNA_methylation1.24888809
63MP0009643_abnormal_urine_homeostasis1.23299169
64MP0000015_abnormal_ear_pigmentation1.22867916
65MP0001293_anophthalmia1.21758372
66MP0008789_abnormal_olfactory_epithelium1.20586117
67MP0004264_abnormal_extraembryonic_tissu1.20301943
68MP0008007_abnormal_cellular_replicative1.19975529
69MP0001545_abnormal_hematopoietic_system1.19701647
70MP0005397_hematopoietic_system_phenotyp1.19701647
71MP0000343_altered_response_to1.19464036
72MP0003718_maternal_effect1.17725006
73MP0003111_abnormal_nucleus_morphology1.16604547
74MP0003786_premature_aging1.15710076
75MP0001756_abnormal_urination1.15127012
76MP0003953_abnormal_hormone_level1.14675288
77MP0005084_abnormal_gallbladder_morpholo1.14557221
78MP0003186_abnormal_redox_activity1.13913785
79MP0002896_abnormal_bone_mineralization1.12538198
80MP0001765_abnormal_ion_homeostasis1.11319836
81MP0009046_muscle_twitch1.07780182
82MP0009764_decreased_sensitivity_to1.07635301
83MP0001324_abnormal_eye_pigmentation1.06162542
84MP0005075_abnormal_melanosome_morpholog1.05041868
85MP0005174_abnormal_tail_pigmentation1.04931900
86MP0005551_abnormal_eye_electrophysiolog1.03892852
87MP0002837_dystrophic_cardiac_calcinosis1.02893842
88MP0001186_pigmentation_phenotype1.02770538
89MP0006036_abnormal_mitochondrial_physio1.02449633
90MP0000631_abnormal_neuroendocrine_gland1.02293716
91MP0001929_abnormal_gametogenesis1.01445181
92MP0000681_abnormal_thyroid_gland1.01133899
93MP0002229_neurodegeneration1.00691838
94MP0003890_abnormal_embryonic-extraembry0.98793925
95MP0005387_immune_system_phenotype0.98712641
96MP0001790_abnormal_immune_system0.98712641
97MP0003795_abnormal_bone_structure0.98419754
98MP0004811_abnormal_neuron_physiology0.97758760
99MP0002419_abnormal_innate_immunity0.97006805
100MP0000920_abnormal_myelination0.96738113
101MP0002067_abnormal_sensory_capabilities0.95782177
102MP0000462_abnormal_digestive_system0.95485998
103MP0005636_abnormal_mineral_homeostasis0.94518278
104MP0002723_abnormal_immune_serum0.93642197
105MP0001486_abnormal_startle_reflex0.92636423
106MP0005464_abnormal_platelet_physiology0.92246276
107MP0005410_abnormal_fertilization0.92237144
108MP0002272_abnormal_nervous_system0.92168391
109MP0002210_abnormal_sex_determination0.91987863
110MP0000371_diluted_coat_color0.91630947
111MP0005367_renal/urinary_system_phenotyp0.91505393
112MP0000516_abnormal_urinary_system0.91505393
113MP0002420_abnormal_adaptive_immunity0.89630787
114MP0001819_abnormal_immune_cell0.89253198
115MP0001764_abnormal_homeostasis0.88997182
116MP0005408_hypopigmentation0.88834052
117MP0002064_seizures0.88487522
118MP0009765_abnormal_xenobiotic_induced0.87778903
119MP0009278_abnormal_bone_marrow0.87640540
120MP0005195_abnormal_posterior_eye0.87343326
121MP0002148_abnormal_hypersensitivity_rea0.87285891
122MP0002452_abnormal_antigen_presenting0.87114618
123MP0001853_heart_inflammation0.86939569
124MP0000613_abnormal_salivary_gland0.85772035
125MP0000955_abnormal_spinal_cord0.84684952
126MP0001970_abnormal_pain_threshold0.83345882
127MP0003787_abnormal_imprinting0.82818645
128MP0002882_abnormal_neuron_morphology0.82632446
129MP0002752_abnormal_somatic_nervous0.82490013
130MP0009745_abnormal_behavioral_response0.82177060
131MP0001905_abnormal_dopamine_level0.81040467
132MP0003436_decreased_susceptibility_to0.80648041
133MP0001485_abnormal_pinna_reflex0.80236758
134MP0003698_abnormal_male_reproductive0.79698848
135MP0002152_abnormal_brain_morphology0.79556088
136MP0003693_abnormal_embryo_hatching0.79188395
137MP0003959_abnormal_lean_body0.79020502
138MP0003763_abnormal_thymus_physiology0.78953848
139MP0005391_vision/eye_phenotype0.78411691
140MP0006082_CNS_inflammation0.78094359
141MP0001845_abnormal_inflammatory_respons0.77756008
142MP0004885_abnormal_endolymph0.75384638
143MP0002398_abnormal_bone_marrow0.75193703
144MP0002163_abnormal_gland_morphology0.74908885
145MP0000569_abnormal_digit_pigmentation0.73957579
146MP0002938_white_spotting0.73359668
147MP0000639_abnormal_adrenal_gland0.72993886
148MP0000716_abnormal_immune_system0.72562903
149MP0002090_abnormal_vision0.72473268
150MP0002095_abnormal_skin_pigmentation0.72041981
151MP0001800_abnormal_humoral_immune0.70053579
152MP0009333_abnormal_splenocyte_physiolog0.70006807
153MP0000358_abnormal_cell_content/0.69643374
154MP0002138_abnormal_hepatobiliary_system0.69583030
155MP0002396_abnormal_hematopoietic_system0.69404159
156MP0000465_gastrointestinal_hemorrhage0.68858720
157MP0009672_abnormal_birth_weight0.68758512
158MP0000538_abnormal_urinary_bladder0.67304885
159MP0001661_extended_life_span0.67018029
160MP0001727_abnormal_embryo_implantation0.66928548
161MP0003943_abnormal_hepatobiliary_system0.66520047
162MP0005253_abnormal_eye_physiology0.66257927
163MP0001270_distended_abdomen0.66035303
164MP0002075_abnormal_coat/hair_pigmentati0.64848817
165MP0003303_peritoneal_inflammation0.63226809
166MP0002751_abnormal_autonomic_nervous0.62331581
167MP0002429_abnormal_blood_cell0.62159792
168MP0001533_abnormal_skeleton_physiology0.62108613
169MP0005025_abnormal_response_to0.61648008
170MP0003634_abnormal_glial_cell0.60601607
171MP0009642_abnormal_blood_homeostasis0.59839813
172MP0000685_abnormal_immune_system0.59390861

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.10215838
2Hypoglycemic seizures (HP:0002173)6.06557731
3Symptomatic seizures (HP:0011145)5.49762213
4Dysostosis multiplex (HP:0000943)5.24341473
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.93382457
6Urinary glycosaminoglycan excretion (HP:0003541)4.84119583
7Mucopolysacchariduria (HP:0008155)4.84119583
8Hypoglycemic coma (HP:0001325)4.74797210
9Abnormality of polysaccharide metabolism (HP:0011012)4.47099635
10Abnormality of glycosaminoglycan metabolism (HP:0004371)4.47099635
11Abnormality of mucopolysaccharide metabolism (HP:0011020)4.47099635
12Increased cerebral lipofuscin (HP:0011813)4.12084985
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.07513798
14Vacuolated lymphocytes (HP:0001922)4.02502396
15Abnormality of liposaccharide metabolism (HP:0010968)3.97607699
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.97607699
17Abnormality of glycolipid metabolism (HP:0010969)3.97607699
18Late onset (HP:0003584)3.67680166
19Abnormality of endocrine pancreas physiology (HP:0012093)3.60229834
20Abnormality of the pancreatic islet cells (HP:0006476)3.60229834
21Large for gestational age (HP:0001520)3.55325238
22Generalized aminoaciduria (HP:0002909)3.41783208
233-Methylglutaconic aciduria (HP:0003535)3.40292525
24Insulin-resistant diabetes mellitus (HP:0000831)3.30507662
25Abnormality of calcium-phosphate metabolism (HP:0100530)3.28140843
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.24257500
27Abnormal protein N-linked glycosylation (HP:0012347)3.24257500
28Abnormal protein glycosylation (HP:0012346)3.24257500
29Abnormal glycosylation (HP:0012345)3.24257500
30Pancreatic islet-cell hyperplasia (HP:0004510)3.17982770
31Hyperglycemia (HP:0003074)3.13952462
32Progressive neurologic deterioration (HP:0002344)3.11453036
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07570397
34Abnormal pancreas size (HP:0012094)3.03406001
35Type I transferrin isoform profile (HP:0003642)3.02918707
36Decreased circulating renin level (HP:0003351)2.97173257
37Molar tooth sign on MRI (HP:0002419)2.82946921
38Abnormality of midbrain morphology (HP:0002418)2.82946921
39Disinhibition (HP:0000734)2.81438586
40Ketoacidosis (HP:0001993)2.76591035
41Mutism (HP:0002300)2.66078598
42Acute necrotizing encephalopathy (HP:0006965)2.61978591
43Volvulus (HP:0002580)2.59206909
44Abnormality of the labia minora (HP:0012880)2.57469028
4511 pairs of ribs (HP:0000878)2.51955084
46Osteomalacia (HP:0002749)2.51808628
47Hypothermia (HP:0002045)2.51689389
48Hypokalemia (HP:0002900)2.50677322
49Intestinal atresia (HP:0011100)2.50581422
50Retinal atrophy (HP:0001105)2.48920245
51Mitochondrial inheritance (HP:0001427)2.47773686
52Retinal dysplasia (HP:0007973)2.45614977
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.45433182
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45433182
55Aplasia/Hypoplasia of the fovea (HP:0008060)2.45289497
56Hypoplasia of the fovea (HP:0007750)2.45289497
57Medial flaring of the eyebrow (HP:0010747)2.45171694
58B lymphocytopenia (HP:0010976)2.45121749
59Lipid accumulation in hepatocytes (HP:0006561)2.44620847
60Acute encephalopathy (HP:0006846)2.43070031
61Increased CSF lactate (HP:0002490)2.41569369
62Thoracolumbar scoliosis (HP:0002944)2.39596226
63Increased hepatocellular lipid droplets (HP:0006565)2.38306935
64Agitation (HP:0000713)2.36242489
65Abnormality of the intrinsic pathway (HP:0010989)2.35304029
66Abnormal mitochondria in muscle tissue (HP:0008316)2.35229312
67Prominent metopic ridge (HP:0005487)2.34684220
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.33309815
69Renal Fanconi syndrome (HP:0001994)2.31084175
70Progressive macrocephaly (HP:0004481)2.29759233
71Panhypogammaglobulinemia (HP:0003139)2.29507474
72Tubulointerstitial nephritis (HP:0001970)2.28302142
73True hermaphroditism (HP:0010459)2.28156676
74Hyperglycinemia (HP:0002154)2.27490299
75Inappropriate behavior (HP:0000719)2.24461387
76Polyphagia (HP:0002591)2.21871923
77Abnormality of the fovea (HP:0000493)2.21519378
78Insulin resistance (HP:0000855)2.19120297
79Nephronophthisis (HP:0000090)2.16820038
80Albinism (HP:0001022)2.16172650
81Hepatocellular necrosis (HP:0001404)2.15947307
82Conjugated hyperbilirubinemia (HP:0002908)2.15774220
83Papilledema (HP:0001085)2.15535740
84Oligodactyly (hands) (HP:0001180)2.14978344
85Abnormality of the corticospinal tract (HP:0002492)2.14262453
86Type II lissencephaly (HP:0007260)2.13672980
87Increased serum pyruvate (HP:0003542)2.12297397
88Hyperparathyroidism (HP:0000843)2.10674753
89Petechiae (HP:0000967)2.08961744
90Cortical dysplasia (HP:0002539)2.08389462
91Nephrogenic diabetes insipidus (HP:0009806)2.08012027
92Dysautonomia (HP:0002459)2.07990269
93Combined immunodeficiency (HP:0005387)2.07864779
94Atrophy/Degeneration involving motor neurons (HP:0007373)2.06597194
95Severe short stature (HP:0003510)2.04849938
96Cerebral hypomyelination (HP:0006808)2.04837105
97Lissencephaly (HP:0001339)2.04352028
98Abnormality of the anterior horn cell (HP:0006802)2.03142501
99Degeneration of anterior horn cells (HP:0002398)2.03142501
100Hypoplasia of the thymus (HP:0000778)2.02746837
101Menstrual irregularities (HP:0000858)2.02691321
102Abnormality of the metopic suture (HP:0005556)2.00486922
103Limb hypertonia (HP:0002509)2.00197783
104Cerebellar dysplasia (HP:0007033)1.94357296
105Broad face (HP:0000283)1.94130786
106Pancreatic fibrosis (HP:0100732)1.93482893
107Increased serum lactate (HP:0002151)1.92619331
108Patchy hypopigmentation of hair (HP:0011365)1.92326262
109Exocrine pancreatic insufficiency (HP:0001738)1.91489800
110Lactic acidosis (HP:0003128)1.91396811
111Abnormality of B cell number (HP:0010975)1.91177293
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90756359
113Abnormality of alanine metabolism (HP:0010916)1.90756359
114Hyperalaninemia (HP:0003348)1.90756359
115Cortical visual impairment (HP:0100704)1.89922190
116White forelock (HP:0002211)1.88975110
117Concave nail (HP:0001598)1.86960069
118Hepatic necrosis (HP:0002605)1.86751943
119Drooling (HP:0002307)1.85739890
120Cardiomegaly (HP:0001640)1.85036996
121CNS hypomyelination (HP:0003429)1.84778375
122Oculomotor apraxia (HP:0000657)1.84629253
123Abnormal biliary tract physiology (HP:0012439)1.83896902
124Bile duct proliferation (HP:0001408)1.83896902
125Widely spaced teeth (HP:0000687)1.83680398
126Chronic bronchitis (HP:0004469)1.83056992
127Microvesicular hepatic steatosis (HP:0001414)1.82915008
128Gait imbalance (HP:0002141)1.82573169
129Aplastic anemia (HP:0001915)1.82544161
130Disproportionate short-trunk short stature (HP:0003521)1.79210191
131Severe combined immunodeficiency (HP:0004430)1.78732673
132Aplasia/hypoplasia of the uterus (HP:0008684)1.78686196
133Congenital primary aphakia (HP:0007707)1.78508429
134Cystic liver disease (HP:0006706)1.78001385
135Decreased subcutaneous fat (HP:0001002)1.77606533
136Abnormality of glycolysis (HP:0004366)1.77441690
137Asymmetric septal hypertrophy (HP:0001670)1.76805783
138Spinal muscular atrophy (HP:0007269)1.75797835
139Abnormality of renin-angiotensin system (HP:0000847)1.75366316
140Abdominal distention (HP:0003270)1.75356522
141Septo-optic dysplasia (HP:0100842)1.74737672
142Abnormality of the renal medulla (HP:0100957)1.74265584
143Agnosia (HP:0010524)1.73161310
144Recurrent abscess formation (HP:0002722)1.73069720
145Constricted visual fields (HP:0001133)1.72969646
146Abolished electroretinogram (ERG) (HP:0000550)1.72564060
147Pancreatic cysts (HP:0001737)1.71768489
148Abnormality of potassium homeostasis (HP:0011042)1.71499262
149Hypophosphatemia (HP:0002148)1.71382162
150Irregular vertebral endplates (HP:0003301)1.71332582
151Birth length less than 3rd percentile (HP:0003561)1.70446728
152Unilateral renal agenesis (HP:0000122)1.69429151
153Missing ribs (HP:0000921)1.68226101
154Reduced antithrombin III activity (HP:0001976)1.67231812
155Cerebral edema (HP:0002181)1.67001974
156Hyperphosphaturia (HP:0003109)1.65862426
157CNS demyelination (HP:0007305)1.65395700
158Excessive salivation (HP:0003781)1.65392294
159Spondylolisthesis (HP:0003302)1.65314711
160Bifid tongue (HP:0010297)1.64430187
161Optic nerve hypoplasia (HP:0000609)1.64166259
162Aganglionic megacolon (HP:0002251)1.62591390
163Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62507221
164Abnormality of T cell physiology (HP:0011840)1.62391611
165Optic disc pallor (HP:0000543)1.62184123
166Amyotrophic lateral sclerosis (HP:0007354)1.62012858
167Aplasia/Hypoplasia of the uvula (HP:0010293)1.61667002
168Aplasia/Hypoplasia of the macula (HP:0008059)1.61505217
169Oligodactyly (HP:0012165)1.60990597
170Glycosuria (HP:0003076)1.60663124
171Abnormality of urine glucose concentration (HP:0011016)1.60663124
172Elevated alkaline phosphatase (HP:0003155)1.59051958
173Pheochromocytoma (HP:0002666)1.58997794
174Hypoplastic pelvis (HP:0008839)1.58647918
175Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57825953
176Abnormal delayed hypersensitivity skin test (HP:0002963)1.57642845
177Hypercortisolism (HP:0001578)1.56018755
178Neuroendocrine neoplasm (HP:0100634)1.55912626
179Thrombocytosis (HP:0001894)1.55125568
180Poor head control (HP:0002421)1.55081012
181IgM deficiency (HP:0002850)1.53423154
182Basal ganglia calcification (HP:0002135)1.52931247
183Abnormality of subcutaneous fat tissue (HP:0001001)1.49453315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK6.06393255
2INSRR6.01761344
3MAPK153.99633839
4FLT33.35351558
5PRKD33.33762293
6MAP4K23.23922069
7BUB13.18376537
8TAOK32.95079254
9HIPK22.82787301
10SCYL22.79047719
11PNCK2.61857830
12VRK22.49417924
13ERN12.47008263
14TRIM282.45809105
15NME22.26037591
16IRAK32.12559538
17CDK192.09298456
18WEE12.02874593
19EIF2AK32.00304286
20PBK2.00009400
21STK161.92125029
22EPHA41.73637524
23SRPK11.70166675
24ITK1.65334898
25BRD41.62405524
26IRAK41.56732180
27KIT1.51414754
28CSNK1G21.49849971
29ZAK1.48452738
30TEC1.47544914
31CSNK1G31.46338902
32CASK1.46081073
33BTK1.45968501
34ZAP701.44734516
35VRK11.43351991
36TESK21.41596736
37TRIB31.40564502
38MAP2K71.38312684
39BRSK21.36292678
40CDC71.35990154
41CSNK1G11.32684655
42CSF1R1.31621203
43PLK41.27381797
44TGFBR21.26475216
45BCR1.23629878
46MST41.22039421
47WNK31.21376561
48TNIK1.21116887
49MAP3K21.20434407
50DYRK21.20148422
51PKN11.19413811
52PLK21.18922510
53PTK61.18272246
54MARK11.16719967
55UHMK11.11905098
56WNK41.11889257
57DYRK1B1.11347615
58YES11.06282584
59CDC42BPA1.06240293
60OXSR11.05110970
61EPHA31.05079520
62MATK1.03938435
63MKNK11.02165970
64CAMKK21.00772369
65KSR11.00318496
66NEK10.99713142
67PLK30.98350357
68IRAK10.97640840
69STK390.96038636
70TBK10.95759348
71SYK0.94494207
72MINK10.93703835
73JAK30.93385492
74NTRK10.92361247
75CDK30.90591313
76MAP3K100.89927695
77PLK10.89871573
78PRKCH0.89092536
79PDGFRA0.88540008
80DYRK30.87892898
81PIM20.87472259
82MAP4K10.86251176
83BMPR1B0.75870505
84NTRK20.72693354
85PTK20.72637906
86TYK20.72285975
87ADRBK20.71005516
88RPS6KA20.70280769
89LYN0.68832331
90TTK0.68138996
91BRSK10.68050214
92CHEK20.67921828
93MAP3K10.67290119
94MAP3K40.66390908
95PIK3CG0.65699605
96PRKCG0.65238238
97EPHB20.64178991
98SIK30.63404134
99ACVR1B0.62070726
100FGFR40.61999171
101FRK0.61830227
102NME10.61188821
103ERBB30.61013930
104CSNK2A10.60429673
105FGR0.59410988
106PRKD20.58567761
107TSSK60.57885857
108CHUK0.57846190
109JAK10.56244835
110AURKA0.56189781
111RPS6KA40.55618483
112JAK20.54917741
113RAF10.53696192
114ABL20.51702337
115AURKB0.50578130
116PDK20.49421195
117LCK0.47850419
118MKNK20.46607392
119EIF2AK20.46461141
120BRAF0.46446459
121PAK30.45980712
122CSNK1A1L0.45965501
123TGFBR10.43411417
124CSK0.43200874
125ATM0.42487643
126CDK140.42379582
127BCKDK0.42085554
128CLK10.41822027
129NUAK10.41505485
130MAP2K20.41336444
131PIM10.40395396
132MARK30.39028578
133CDK180.37809259
134STK38L0.37590335
135CSNK2A20.37536471
136MET0.35755555
137ATR0.35644383
138CDK80.35170035
139CHEK10.35005430
140CDK11A0.34494340
141EIF2AK10.34417777
142STK100.34199973
143RPS6KA60.33190786
144PRKCD0.32864293
145CDK150.31848180
146CCNB10.31503328
147IGF1R0.31079152
148MAPK30.30607685
149MAP3K50.29960537
150PRKCE0.29821910
151GRK70.28242080
152MAPKAPK20.27789379
153RPS6KC10.27303015
154RPS6KL10.27303015
155NLK0.26243996
156RET0.25703251
157PRKDC0.24193891
158FES0.23773467
159AKT10.23202900
160MAPK130.21727150
161RPS6KA50.21570249
162RPS6KB10.20839134
163TESK10.20170586
164DYRK1A0.19871908
165MAPK140.19397401
166TLK10.19055772
167CDK90.18628843
168NEK90.17907466

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.91574752
2Protein export_Homo sapiens_hsa030606.15050886
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.10887432
4Proteasome_Homo sapiens_hsa030503.02033478
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.98976449
6Oxidative phosphorylation_Homo sapiens_hsa001902.92495984
7Other glycan degradation_Homo sapiens_hsa005112.88795392
8Lysosome_Homo sapiens_hsa041422.61333606
9Parkinsons disease_Homo sapiens_hsa050122.60565217
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56956325
11Sulfur metabolism_Homo sapiens_hsa009202.46363876
12N-Glycan biosynthesis_Homo sapiens_hsa005102.45657649
13Fanconi anemia pathway_Homo sapiens_hsa034602.36776334
14Steroid biosynthesis_Homo sapiens_hsa001002.23252648
15Vibrio cholerae infection_Homo sapiens_hsa051102.10447155
16Insulin secretion_Homo sapiens_hsa049112.05716754
17Asthma_Homo sapiens_hsa053102.03817942
18Ribosome_Homo sapiens_hsa030101.91290921
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86742422
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83557310
21Type I diabetes mellitus_Homo sapiens_hsa049401.81747664
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66023851
23Huntingtons disease_Homo sapiens_hsa050161.62725342
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61783864
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53260017
26RNA transport_Homo sapiens_hsa030131.51765625
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50480622
28Type II diabetes mellitus_Homo sapiens_hsa049301.46994220
29Selenocompound metabolism_Homo sapiens_hsa004501.46766707
30Antigen processing and presentation_Homo sapiens_hsa046121.43765980
31Alzheimers disease_Homo sapiens_hsa050101.32679556
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30147436
33Sulfur relay system_Homo sapiens_hsa041221.18535499
34Legionellosis_Homo sapiens_hsa051341.15686717
35Regulation of autophagy_Homo sapiens_hsa041401.15045708
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.14695728
37Fatty acid elongation_Homo sapiens_hsa000621.14230259
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11688977
39Non-homologous end-joining_Homo sapiens_hsa034501.07114132
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04744086
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03164109
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00217276
43p53 signaling pathway_Homo sapiens_hsa041150.99714335
44Allograft rejection_Homo sapiens_hsa053300.99395388
45Phagosome_Homo sapiens_hsa041450.98477045
46Cocaine addiction_Homo sapiens_hsa050300.97834264
47Propanoate metabolism_Homo sapiens_hsa006400.97442178
48Folate biosynthesis_Homo sapiens_hsa007900.95474729
49Oocyte meiosis_Homo sapiens_hsa041140.91573223
50Sphingolipid metabolism_Homo sapiens_hsa006000.89590952
51mRNA surveillance pathway_Homo sapiens_hsa030150.89316601
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86611038
53Galactose metabolism_Homo sapiens_hsa000520.84338891
54Systemic lupus erythematosus_Homo sapiens_hsa053220.84045469
55Graft-versus-host disease_Homo sapiens_hsa053320.81707827
56Collecting duct acid secretion_Homo sapiens_hsa049660.81669691
57Autoimmune thyroid disease_Homo sapiens_hsa053200.80097467
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79450239
59Salmonella infection_Homo sapiens_hsa051320.74319638
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72629457
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.72566065
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70558322
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69795455
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69631798
65Prolactin signaling pathway_Homo sapiens_hsa049170.67726196
66Phototransduction_Homo sapiens_hsa047440.66885402
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66642535
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64372336
69Insulin resistance_Homo sapiens_hsa049310.63171602
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.62571645
71Butanoate metabolism_Homo sapiens_hsa006500.61513793
72Nicotine addiction_Homo sapiens_hsa050330.60088391
73Mismatch repair_Homo sapiens_hsa034300.59952919
74Alcoholism_Homo sapiens_hsa050340.59166688
75Leishmaniasis_Homo sapiens_hsa051400.58535032
76Synaptic vesicle cycle_Homo sapiens_hsa047210.55770565
77Peroxisome_Homo sapiens_hsa041460.53896415
78Pertussis_Homo sapiens_hsa051330.52568591
79DNA replication_Homo sapiens_hsa030300.52438901
80Hematopoietic cell lineage_Homo sapiens_hsa046400.51559251
81Osteoclast differentiation_Homo sapiens_hsa043800.51134732
82Metabolic pathways_Homo sapiens_hsa011000.50895314
83B cell receptor signaling pathway_Homo sapiens_hsa046620.47960617
84Measles_Homo sapiens_hsa051620.47527679
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47430387
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47319048
87Circadian rhythm_Homo sapiens_hsa047100.46738359
88Tuberculosis_Homo sapiens_hsa051520.45612210
89Glutathione metabolism_Homo sapiens_hsa004800.45320898
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45037335
91Base excision repair_Homo sapiens_hsa034100.44638393
92Nitrogen metabolism_Homo sapiens_hsa009100.43833621
93Thyroid hormone synthesis_Homo sapiens_hsa049180.43722840
94Glucagon signaling pathway_Homo sapiens_hsa049220.43423287
95Viral carcinogenesis_Homo sapiens_hsa052030.42996170
96Rheumatoid arthritis_Homo sapiens_hsa053230.42406651
97Spliceosome_Homo sapiens_hsa030400.41614568
98Epstein-Barr virus infection_Homo sapiens_hsa051690.40786987
99Pyrimidine metabolism_Homo sapiens_hsa002400.40576070
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40356008
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40229659
102Nucleotide excision repair_Homo sapiens_hsa034200.39807769
103Ether lipid metabolism_Homo sapiens_hsa005650.39151977
104Pancreatic secretion_Homo sapiens_hsa049720.38663408
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37903814
106Herpes simplex infection_Homo sapiens_hsa051680.37854122
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37652402
108ABC transporters_Homo sapiens_hsa020100.35717527
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.35543356
110Chronic myeloid leukemia_Homo sapiens_hsa052200.35532809
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34909659
112Olfactory transduction_Homo sapiens_hsa047400.34416754
113Cell cycle_Homo sapiens_hsa041100.33428237
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33253215
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33051518
116Hepatitis B_Homo sapiens_hsa051610.32722127
117Prion diseases_Homo sapiens_hsa050200.32603644
118Lysine degradation_Homo sapiens_hsa003100.32551632
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31328726
120Apoptosis_Homo sapiens_hsa042100.30420497
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30408115
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28792768
123Shigellosis_Homo sapiens_hsa051310.28334802
124Basal transcription factors_Homo sapiens_hsa030220.28267671
125Renin-angiotensin system_Homo sapiens_hsa046140.28109769
126Toxoplasmosis_Homo sapiens_hsa051450.26372876
127Chemokine signaling pathway_Homo sapiens_hsa040620.26250589
128Taste transduction_Homo sapiens_hsa047420.26097584
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24961924
130Purine metabolism_Homo sapiens_hsa002300.24545067
131Viral myocarditis_Homo sapiens_hsa054160.24375095
132Amphetamine addiction_Homo sapiens_hsa050310.24108574
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23932815
134Endocytosis_Homo sapiens_hsa041440.23836517
135Homologous recombination_Homo sapiens_hsa034400.23742003
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23573564
137Notch signaling pathway_Homo sapiens_hsa043300.23210519
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23199143
139Primary immunodeficiency_Homo sapiens_hsa053400.22451023
140Insulin signaling pathway_Homo sapiens_hsa049100.21978392
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21877608
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.21088378
143Thyroid cancer_Homo sapiens_hsa052160.20426134
144RNA polymerase_Homo sapiens_hsa030200.20354990
145Starch and sucrose metabolism_Homo sapiens_hsa005000.18660492
146RNA degradation_Homo sapiens_hsa030180.18389393
147Pancreatic cancer_Homo sapiens_hsa052120.17589446
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16952733
149Influenza A_Homo sapiens_hsa051640.16768128

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