ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to mercury ion (GO:0046689)	9.80215355
2	one-carbon compound transport (GO:0019755)	8.00427086
3	metanephric nephron tubule development (GO:0072234)	7.83842161
4	metanephric tubule development (GO:0072170)	7.83842161
5	collecting duct development (GO:0072044)	7.39922417
6	metanephric nephron epithelium development (GO:0072243)	7.18173270
7	actin filament depolymerization (GO:0030042)	6.80235587
8	metanephric epithelium development (GO:0072207)	6.67964245
9	response to water (GO:0009415)	6.28948399
10	lysine metabolic process (GO:0006553)	5.78391482
11	lysine catabolic process (GO:0006554)	5.78391482
12	nephron tubule development (GO:0072080)	5.61213774
13	drug transmembrane transport (GO:0006855)	5.61059412
14	cell volume homeostasis (GO:0006884)	5.60913167
15	urate metabolic process (GO:0046415)	5.30457946
16	sphingomyelin metabolic process (GO:0006684)	5.26807904
17	drug transport (GO:0015893)	5.14925772
18	cardiovascular system development (GO:0072358)	4.94931028
19	renal tubule development (GO:0061326)	4.94652713
20	organic cation transport (GO:0015695)	4.73737194
21	response to copper ion (GO:0046688)	4.71740499
22	aminoglycoside antibiotic metabolic process (GO:0030647)	4.68097768
23	hyperosmotic response (GO:0006972)	4.55344160
24	homocysteine metabolic process (GO:0050667)	4.54759441
25	nephron epithelium development (GO:0072009)	4.51442102
26	renal system process (GO:0003014)	4.24573500
27	water transport (GO:0006833)	4.18722390
28	branched-chain amino acid metabolic process (GO:0009081)	4.04436116
29	branched-chain amino acid catabolic process (GO:0009083)	3.97828118
30	response to salt stress (GO:0009651)	3.97286457
31	aspartate family amino acid catabolic process (GO:0009068)	3.95767767
32	fluid transport (GO:0042044)	3.94891708
33	phosphate ion transport (GO:0006817)	3.86707662
34	phospholipid scrambling (GO:0017121)	3.70207503
35	quaternary ammonium group transport (GO:0015697)	3.63423465
36	nonribosomal peptide biosynthetic process (GO:0019184)	3.57339872
37	nephron tubule morphogenesis (GO:0072078)	3.55782133
38	nephron epithelium morphogenesis (GO:0072088)	3.55782133
39	hyperosmotic salinity response (GO:0042538)	3.55723388
40	tryptophan catabolic process (GO:0006569)	3.53677775
41	indole-containing compound catabolic process (GO:0042436)	3.53677775
42	indolalkylamine catabolic process (GO:0046218)	3.53677775
43	phosphate ion homeostasis (GO:0055062)	3.46688164
44	trivalent inorganic anion homeostasis (GO:0072506)	3.46688164
45	toxin transport (GO:1901998)	3.41849201
46	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.40623665
47	valine metabolic process (GO:0006573)	3.38695246
48	cysteine metabolic process (GO:0006534)	3.35004750
49	vitamin D metabolic process (GO:0042359)	3.34291497
50	glutathione biosynthetic process (GO:0006750)	3.33728833
51	2-oxoglutarate metabolic process (GO:0006103)	3.32826602
52	phosphate ion transmembrane transport (GO:0035435)	3.31436675
53	carnitine metabolic process (GO:0009437)	3.30592992
54	detection of bacterium (GO:0016045)	3.29422883
55	positive regulation of digestive system process (GO:0060456)	3.25679858
56	tryptophan metabolic process (GO:0006568)	3.25461544
57	inositol metabolic process (GO:0006020)	3.25043309
58	interferon-gamma production (GO:0032609)	3.24840394
59	oligosaccharide catabolic process (GO:0009313)	3.24029341
60	cellular ketone body metabolic process (GO:0046950)	3.18983583
61	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.17826066
62	transepithelial transport (GO:0070633)	3.15656593
63	amino-acid betaine metabolic process (GO:0006577)	3.15627893
64	short-chain fatty acid metabolic process (GO:0046459)	3.15127643
65	nephron tubule formation (GO:0072079)	3.14329768
66	regulation of fever generation (GO:0031620)	3.13484996
67	sodium ion transport (GO:0006814)	3.09408712
68	glyoxylate metabolic process (GO:0046487)	3.06325596
69	exogenous drug catabolic process (GO:0042738)	3.04751313
70	aromatic amino acid family catabolic process (GO:0009074)	3.03062343
71	detection of other organism (GO:0098543)	3.00308939
72	renal tubule morphogenesis (GO:0061333)	2.97261343
73	drug catabolic process (GO:0042737)	2.96863211
74	positive regulation of systemic arterial blood pressure (GO:0003084)	2.96345661
75	positive regulation of heat generation (GO:0031652)	2.95612031
76	amino-acid betaine transport (GO:0015838)	2.91510677
77	carnitine transport (GO:0015879)	2.91510677
78	fatty acid beta-oxidation (GO:0006635)	2.90325843
79	response to phenylpropanoid (GO:0080184)	2.89283156
80	inorganic anion transport (GO:0015698)	2.89172170
81	cellular modified amino acid catabolic process (GO:0042219)	2.86174956
82	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.84743079
83	indolalkylamine metabolic process (GO:0006586)	2.83744184
84	tricarboxylic acid metabolic process (GO:0072350)	2.81637695
85	L-phenylalanine metabolic process (GO:0006558)	2.80072260
86	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.80072260
87	wound healing, spreading of epidermal cells (GO:0035313)	2.79543757
88	pattern specification involved in kidney development (GO:0061004)	2.78630302
89	glycoside metabolic process (GO:0016137)	2.76040966
90	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.70642440
91	biotin metabolic process (GO:0006768)	2.69791551
92	kynurenine metabolic process (GO:0070189)	2.67866393
93	sphingosine metabolic process (GO:0006670)	2.64271468
94	fatty acid oxidation (GO:0019395)	2.64158701
95	ketone body metabolic process (GO:1902224)	2.64075473
96	tricarboxylic acid cycle (GO:0006099)	2.63464132
97	lipid oxidation (GO:0034440)	2.63056068
98	polyol transport (GO:0015791)	12.8734853
99	excretion (GO:0007588)	10.6246367
100	renal absorption (GO:0070293)	10.1166655

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.58962675
2	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.32481854
3	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.07280836
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.78727915
5	VDR_22108803_ChIP-Seq_LS180_Human	2.59839974
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.50568574
7	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.38764984
8	RXR_22108803_ChIP-Seq_LS180_Human	2.00537967
9	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.95597442
10	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.91442103
11	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.89464684
12	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.87821265
13	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.86735284
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.84901214
15	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.81790954
16	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.77828958
17	* BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.73414241
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69765230
19	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.67067961
20	EGR1_19032775_ChIP-ChIP_M12_Human	1.66253747
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.60754135
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.59698511
23	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58053614
24	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.57347171
25	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.56899598
26	TP53_18474530_ChIP-ChIP_U2OS_Human	1.56284917
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.55627355
28	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.54305171
29	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.50768652
30	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.50356900
31	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.50277193
32	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.48968863
33	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.48607873
34	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.47710982
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46603445
36	VDR_24787735_ChIP-Seq_THP-1_Human	1.45922079
37	SOX2_20726797_ChIP-Seq_SW620_Human	1.43196185
38	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.41648395
39	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.41360583
40	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.40861089
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40595140
42	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.34147514
43	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.33616997
44	AHR_22903824_ChIP-Seq_MCF-7_Human	1.33485260
45	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.30997637
46	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.30997637
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.29659335
48	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.29528088
49	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.26734045
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22258683
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22139469
52	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.22064173
53	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.21462901
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.21249369
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20437810
56	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.19846376
57	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.19689590
58	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.17525415
59	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.17445476
60	CJUN_26792858_Chip-Seq_BT549_Human	1.17089472
61	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.16507559
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15920150
63	* GATA4_25053715_ChIP-Seq_YYC3_Human	1.14930175
64	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.13452413
65	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13143409
66	P300_19829295_ChIP-Seq_ESCs_Human	1.12755972
67	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.12242891
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11617850
69	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.11291424
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.11213497
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08232463
72	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07927642
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.07721730
74	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07315700
75	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.06188058
76	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.05288364
77	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.04938960
78	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.03861758
79	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.01978864
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01228825
81	TAF15_26573619_Chip-Seq_HEK293_Human	0.99835811
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99141244
83	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.98160387
84	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.97636441
85	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97098686
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97066395
87	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.96128534
88	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.95247269
89	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.94935071
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.94486230
91	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.94152113
92	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.93967428
93	TP63_23658742_ChIP-Seq_EP156T_Human	0.93286270
94	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.93066641
95	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.92531520
96	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.92417798
97	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.92049314
98	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.92049314
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.91664450
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.90585961

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004043_abnormal_pH_regulation	9.45029825
2	MP0003195_calcinosis	8.27593347
3	MP0001756_abnormal_urination	5.85702409
4	MP0009643_abnormal_urine_homeostasis	3.58996603
5	MP0001765_abnormal_ion_homeostasis	3.56876090
6	MP0005332_abnormal_amino_acid	3.35892223
7	MP0002136_abnormal_kidney_physiology	3.07865797
8	MP0005360_urolithiasis	2.98962208
9	MP0002138_abnormal_hepatobiliary_system	2.81361312
10	MP0004885_abnormal_endolymph	2.77464275
11	MP0004019_abnormal_vitamin_homeostasis	2.70653667
12	MP0005636_abnormal_mineral_homeostasis	2.67877991
13	MP0003283_abnormal_digestive_organ	2.64901400
14	MP0000538_abnormal_urinary_bladder	2.37762621
15	MP0002139_abnormal_hepatobiliary_system	2.20167703
16	MP0008961_abnormal_basal_metabolism	2.12324861
17	MP0003646_muscle_fatigue	1.89789546
18	MP0005377_hearing/vestibular/ear_phenot	1.67862000
19	MP0003878_abnormal_ear_physiology	1.67862000
20	MP0002168_other_aberrant_phenotype	1.61811645
21	MP0000534_abnormal_ureter_morphology	1.51110109
22	MP0003191_abnormal_cellular_cholesterol	1.44423507
23	MP0001270_distended_abdomen	1.42111714
24	MP0003252_abnormal_bile_duct	1.38703531
25	MP0003941_abnormal_skin_development	1.35515606
26	MP0008004_abnormal_stomach_pH	1.29105433
27	MP0002896_abnormal_bone_mineralization	1.23203810
28	MP0002933_joint_inflammation	1.20811196
29	MP0009278_abnormal_bone_marrow	1.19064475
30	MP0005085_abnormal_gallbladder_physiolo	1.17852963
31	MP0002876_abnormal_thyroid_physiology	1.15822823
32	MP0002135_abnormal_kidney_morphology	1.14403250
33	MP0002928_abnormal_bile_duct	1.10335363
34	MP0004147_increased_porphyrin_level	1.09506441
35	MP0001764_abnormal_homeostasis	1.08965044
36	MP0002234_abnormal_pharynx_morphology	1.07753518
37	MP0000230_abnormal_systemic_arterial	1.07647413
38	MP0005395_other_phenotype	1.03929175
39	MP0004742_abnormal_vestibular_system	1.03798002
40	MP0002089_abnormal_postnatal_growth/wei	1.00683913
41	MP0000163_abnormal_cartilage_morphology	0.99174904
42	MP0002282_abnormal_trachea_morphology	0.96524749
43	MP0002115_abnormal_skeleton_extremities	0.95991026
44	MP0000762_abnormal_tongue_morphology	0.95869205
45	MP0003959_abnormal_lean_body	0.95211924
46	MP0002796_impaired_skin_barrier	0.94056504
47	MP0001958_emphysema	0.92431093
48	MP0005535_abnormal_body_temperature	0.92124248
49	MP0009379_abnormal_foot_pigmentation	0.89779531
50	MP0001188_hyperpigmentation	0.89507997
51	MP0005451_abnormal_body_composition	0.87517733
52	MP0005503_abnormal_tendon_morphology	0.87331950
53	MP0005365_abnormal_bile_salt	0.86834817
54	MP0003795_abnormal_bone_structure	0.83110682
55	MP0005084_abnormal_gallbladder_morpholo	0.77917123
56	MP0001299_abnormal_eye_distance/	0.77873925
57	MP0002736_abnormal_nociception_after	0.76769396
58	MP0010386_abnormal_urinary_bladder	0.75955528
59	MP0004264_abnormal_extraembryonic_tissu	0.74688265
60	MP0005584_abnormal_enzyme/coenzyme_acti	0.70718411
61	MP0004484_altered_response_of	0.69618797
62	MP0009780_abnormal_chondrocyte_physiolo	0.68923929
63	MP0003186_abnormal_redox_activity	0.68555358
64	MP0009764_decreased_sensitivity_to	0.67499300
65	MP0005319_abnormal_enzyme/_coenzyme	0.66899428
66	MP0010234_abnormal_vibrissa_follicle	0.66891732
67	MP0003436_decreased_susceptibility_to	0.66351087
68	MP0001963_abnormal_hearing_physiology	0.66216332
69	MP0002998_abnormal_bone_remodeling	0.66111001
70	MP0001177_atelectasis	0.64692308
71	MP0002113_abnormal_skeleton_development	0.64052112
72	MP0005501_abnormal_skin_physiology	0.63475962
73	MP0001986_abnormal_taste_sensitivity	0.60874052
74	MP0000372_irregular_coat_pigmentation	0.60862872
75	MP0002098_abnormal_vibrissa_morphology	0.59552669
76	MP0001873_stomach_inflammation	0.58682353
77	MP0004272_abnormal_basement_membrane	0.57171976
78	MP0008875_abnormal_xenobiotic_pharmacok	0.56582613
79	MP0002735_abnormal_chemical_nociception	0.55044956
80	MP0002148_abnormal_hypersensitivity_rea	0.53793184
81	MP0000026_abnormal_inner_ear	0.53039298
82	MP0001533_abnormal_skeleton_physiology	0.52934972
83	MP0001542_abnormal_bone_strength	0.52455137
84	MP0003942_abnormal_urinary_system	0.51265268
85	MP0002069_abnormal_eating/drinking_beha	0.50817732
86	MP0001191_abnormal_skin_condition	0.48598677
87	MP0005165_increased_susceptibility_to	0.46424211
88	MP0009642_abnormal_blood_homeostasis	0.45377799
89	MP0003638_abnormal_response/metabolism_	0.45231602
90	MP0003724_increased_susceptibility_to	0.44536032
91	MP0001664_abnormal_digestion	0.44521440
92	MP0004134_abnormal_chest_morphology	0.42283571
93	MP0005220_abnormal_exocrine_pancreas	0.42214102
94	MP0009250_abnormal_appendicular_skeleto	0.41686754
95	MP0006276_abnormal_autonomic_nervous	0.40985022
96	MP0004133_heterotaxia	0.39709485
97	MP0004381_abnormal_hair_follicle	0.39255978
98	MP0005390_skeleton_phenotype	0.38296378
99	MP0006036_abnormal_mitochondrial_physio	0.38018927
100	MP0004782_abnormal_surfactant_physiolog	0.36735936

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of chloride homeostasis (HP:0011422)	9.15166322
2	Polyuria (HP:0000103)	8.62184640
3	Hyperactive renin-angiotensin system (HP:0000841)	8.44850062
4	Increased circulating renin level (HP:0000848)	8.42509069
5	Hypomagnesemia (HP:0002917)	8.10667788
6	Abnormal urine output (HP:0012590)	7.91263720
7	Hyperaldosteronism (HP:0000859)	7.58658469
8	Renal salt wasting (HP:0000127)	7.50733854
9	Abnormality of renal excretion (HP:0011036)	7.06041001
10	Abnormality of magnesium homeostasis (HP:0004921)	6.96948557
11	Polydipsia (HP:0001959)	6.54545025
12	Abnormal drinking behavior (HP:0030082)	6.54545025
13	Tetany (HP:0001281)	6.32154535
14	Alkalosis (HP:0001948)	5.94412512
15	Abnormality of renin-angiotensin system (HP:0000847)	5.28148335
16	Hypokalemia (HP:0002900)	4.96114712
17	Abnormality of sodium homeostasis (HP:0010931)	4.20255167
18	Gout (HP:0001997)	3.95381416
19	Abnormality of potassium homeostasis (HP:0011042)	3.93234822
20	Adrenal overactivity (HP:0002717)	3.67610786
21	Hypercalciuria (HP:0002150)	3.54782446
22	Hyponatremia (HP:0002902)	3.53512128
23	Abnormality of fatty-acid metabolism (HP:0004359)	3.29917345
24	Epiphyseal dysplasia (HP:0002656)	3.21590062
25	Hyperuricemia (HP:0002149)	2.87578656
26	Increased purine levels (HP:0004368)	2.87578656
27	Dehydration (HP:0001944)	2.50796280
28	Abnormal tarsal ossification (HP:0008369)	2.49971912
29	Nephrocalcinosis (HP:0000121)	2.48487791
30	Chondrocalcinosis (HP:0000934)	2.47224824
31	Irregular epiphyses (HP:0010582)	2.43263830
32	Proximal tubulopathy (HP:0000114)	2.40108416
33	Abnormality of Sharpey fibers (HP:0100685)	2.39874543
34	Vitreoretinal degeneration (HP:0000655)	2.33939011
35	Delayed epiphyseal ossification (HP:0002663)	2.29835489
36	Decreased circulating renin level (HP:0003351)	2.22526406
37	Generalized muscle weakness (HP:0003324)	2.14099307
38	Large eyes (HP:0001090)	2.09339347
39	Abnormality of purine metabolism (HP:0004352)	2.07681776
40	Neonatal short-limb short stature (HP:0008921)	2.03822995
41	Metabolic alkalosis (HP:0200114)	11.5980130
42	Hypokalemic alkalosis (HP:0001949)	10.3836061
43	Hyperglycinuria (HP:0003108)	1.96845681
44	Hypotension (HP:0002615)	1.92406866
45	Renal tubular acidosis (HP:0001947)	1.91624716
46	Flat capital femoral epiphysis (HP:0003370)	1.88112532
47	Hypoplastic ischia (HP:0003175)	1.83297154
48	Ketoacidosis (HP:0001993)	1.83192736
49	Neonatal onset (HP:0003623)	1.82976980
50	Cupped ribs (HP:0000887)	1.79483245
51	Abnormality of the renal cortex (HP:0011035)	1.78961418
52	Vomiting (HP:0002013)	1.76361338
53	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.72911462
54	Tubulointerstitial fibrosis (HP:0005576)	1.72099776
55	Metaphyseal cupping (HP:0003021)	1.62601951
56	Abnormal foot bone ossification (HP:0010675)	1.61763396
57	Metaphyseal irregularity (HP:0003025)	1.60521366
58	Generalized aminoaciduria (HP:0002909)	1.60353153
59	Short femoral neck (HP:0100864)	1.60213748
60	Abnormality of carpal bone ossification (HP:0006257)	1.58940600
61	Metaphyseal dysplasia (HP:0100255)	1.58356775
62	Abnormality of the ischium (HP:0003174)	1.55691835
63	Arthropathy (HP:0003040)	1.53798953
64	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.53046734
65	Flattened epiphyses (HP:0003071)	1.52905613
66	Abnormality of serine family amino acid metabolism (HP:0010894)	1.52123167
67	Abnormality of glycine metabolism (HP:0010895)	1.52123167
68	Abnormality of urine glucose concentration (HP:0011016)	1.51543714
69	Glycosuria (HP:0003076)	1.51543714
70	Flat acetabular roof (HP:0003180)	1.51206628
71	Tubular atrophy (HP:0000092)	1.47500202
72	Impaired platelet aggregation (HP:0003540)	1.46605624
73	Abnormal platelet function (HP:0011869)	1.46605624
74	Protuberant abdomen (HP:0001538)	1.46593902
75	Vascular calcification (HP:0004934)	1.45328389
76	Genu varum (HP:0002970)	1.41406959
77	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.38105926
78	Abnormality of nucleobase metabolism (HP:0010932)	1.35123187
79	Abnormality of the vertebral endplates (HP:0005106)	1.34332596
80	Potter facies (HP:0002009)	1.33920671
81	Facial shape deformation (HP:0011334)	1.33920671
82	Abnormality of the renal medulla (HP:0100957)	1.33762087
83	Ketosis (HP:0001946)	1.32650058
84	Small epiphyses (HP:0010585)	1.32264659
85	Abnormality of femoral epiphyses (HP:0006499)	1.31980755
86	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.31980755
87	Premature birth (HP:0001622)	1.27910070
88	Cardiovascular calcification (HP:0011915)	1.24211760
89	Abnormality of proline metabolism (HP:0010907)	1.24169341
90	Hydroxyprolinuria (HP:0003080)	1.24169341
91	Disproportionate short-trunk short stature (HP:0003521)	1.23278481
92	Enlarged kidneys (HP:0000105)	1.23033468
93	Abnormality of renal resorption (HP:0011038)	1.23018985
94	Hyperphosphaturia (HP:0003109)	1.22517935
95	Bilateral sensorineural hearing impairment (HP:0008619)	1.22218389
96	Abnormal urine phosphate concentration (HP:0012599)	1.22198275
97	Renal tubular dysfunction (HP:0000124)	1.20030993
98	Glomerulosclerosis (HP:0000096)	1.18509487
99	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.17535184
100	Abnormality of the femoral head (HP:0003368)	1.16736101

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OXSR1	7.20054752
2	WNK4	4.87216778
3	SGK2	2.57184671
4	SGK223	2.34634200
5	SGK494	2.34634200
6	MST4	2.05472644
7	WNK3	12.4512196
8	SGK3	1.85776267
9	BCKDK	1.59917067
10	STK39	1.43590661
11	MST1R	1.37864105
12	STK38L	1.36534860
13	WNK1	1.23506204
14	PDK3	1.16517605
15	PDK4	1.16517605
16	INSRR	1.05555742
17	PDK2	1.02037620
18	ERBB3	0.97306638
19	DDR2	0.81422349
20	NME1	0.77016844
21	GRK1	0.74775339
22	MUSK	0.74682217
23	IRAK2	0.67405356
24	MAP3K3	0.66630751
25	STK38	0.61876034
26	TGFBR2	0.57170431
27	AKT3	0.56862423
28	TRPM7	0.56447322
29	SGK1	0.56034562
30	TIE1	0.55566438
31	NLK	0.53363181
32	PRKG2	0.50802478
33	EPHA2	0.47182504
34	PINK1	0.45504801
35	PIK3CG	0.43902431
36	ADRBK2	0.43293741
37	MAPKAPK5	0.43279430
38	IRAK3	0.40462987
39	MAP3K14	0.40432419
40	FGFR4	0.40078254
41	CASK	0.37074482
42	MAPK15	0.36880039
43	TXK	0.35867466
44	PRKCD	0.32751234
45	PIM2	0.32606211
46	IRAK1	0.32465969
47	PRKAA1	0.30090775
48	NUAK1	0.28364553
49	NEK6	0.28089524
50	CSNK1A1	0.28000904
51	MAPK7	0.27472280
52	LRRK2	0.27153129
53	YES1	0.25443369
54	TEC	0.23991134
55	MET	0.23755741
56	PRKCE	0.23321497
57	PAK3	0.22883953
58	MAP2K2	0.21279171
59	PRKACA	0.21047514
60	PRKCQ	0.19832546
61	GSK3A	0.19739575
62	ITK	0.19150102
63	MAP3K12	0.18943334
64	MKNK1	0.17747004
65	BCR	0.17707498
66	NME2	0.17548935
67	NTRK2	0.16677081
68	PRKACG	0.15843052
69	PRKCA	0.15098050
70	GRK6	0.15050776
71	MAP3K7	0.14878322
72	IGF1R	0.14401036
73	MAPK4	0.13819723
74	EIF2AK2	0.13441100
75	EPHA4	0.13391704
76	MAP2K6	0.12893572
77	EPHB2	0.12522620
78	ADRBK1	0.11439910
79	PAK4	0.10220993
80	CHUK	0.10067753
81	FER	0.08767531
82	PRKCI	0.08517615
83	CAMK4	0.08068621
84	BMPR2	0.08059756
85	NEK1	0.07734639
86	PIM1	0.07373534
87	PRKCZ	0.06877081
88	PDGFRA	0.06788088
89	PRKCH	0.06719668
90	IKBKB	0.05731200
91	PRKCG	0.05191500
92	SRC	0.04978569
93	CAMK2A	0.04896276
94	CSK	0.04415819
95	AURKB	0.03518480
96	NTRK1	0.03159676
97	MAPK3	0.02926192
98	GRK7	0.02673725
99	ROCK1	0.02433262
100	MELK	0.02334221

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	4.70118448
2	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	3.65764384
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.25821901
4	Propanoate metabolism_Homo sapiens_hsa00640	3.04675327
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.98015559
6	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.94102346
7	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.88771395
8	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.60755988
9	Butanoate metabolism_Homo sapiens_hsa00650	2.57682937
10	Sulfur metabolism_Homo sapiens_hsa00920	2.40371834
11	Protein digestion and absorption_Homo sapiens_hsa04974	2.34465677
12	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.31545487
13	Collecting duct acid secretion_Homo sapiens_hsa04966	2.22804271
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.22334986
15	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.03767601
16	Oxidative phosphorylation_Homo sapiens_hsa00190	2.00094477
17	Sphingolipid metabolism_Homo sapiens_hsa00600	1.93304265
18	Fatty acid degradation_Homo sapiens_hsa00071	1.90716383
19	Other glycan degradation_Homo sapiens_hsa00511	1.89151800
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77500991
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.73395870
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.73030762
23	Mineral absorption_Homo sapiens_hsa04978	1.65279710
24	Bile secretion_Homo sapiens_hsa04976	1.62114150
25	Peroxisome_Homo sapiens_hsa04146	1.54080350
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.47744181
27	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.43737195
28	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.31658430
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.29372244
30	Parkinsons disease_Homo sapiens_hsa05012	1.29364072
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.26901673
32	Carbon metabolism_Homo sapiens_hsa01200	1.23771133
33	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.22691532
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19893568
35	ECM-receptor interaction_Homo sapiens_hsa04512	1.19596226
36	Glutathione metabolism_Homo sapiens_hsa00480	1.18060119
37	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.16715777
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.14087917
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.10261614
40	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.09640285
41	Folate biosynthesis_Homo sapiens_hsa00790	1.04518136
42	Rheumatoid arthritis_Homo sapiens_hsa05323	1.02914617
43	Gastric acid secretion_Homo sapiens_hsa04971	1.02807910
44	Alzheimers disease_Homo sapiens_hsa05010	0.91075428
45	PPAR signaling pathway_Homo sapiens_hsa03320	0.90272303
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.87913228
47	Arginine and proline metabolism_Homo sapiens_hsa00330	0.83576584
48	Arginine biosynthesis_Homo sapiens_hsa00220	0.83227751
49	Phenylalanine metabolism_Homo sapiens_hsa00360	0.82349355
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82036313
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.82008272
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.78707278
53	Lysine degradation_Homo sapiens_hsa00310	0.77508879
54	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.70391653
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69412128
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65247651
57	Vibrio cholerae infection_Homo sapiens_hsa05110	0.64847344
58	Fatty acid elongation_Homo sapiens_hsa00062	0.63737954
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59546024
60	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.59328770
61	Huntingtons disease_Homo sapiens_hsa05016	0.57646537
62	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.54906661
63	Hepatitis C_Homo sapiens_hsa05160	0.53889445
64	Metabolic pathways_Homo sapiens_hsa01100	0.49196208
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47145191
66	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.46188850
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44820525
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.44524399
69	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.43799763
70	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.41643162
71	ABC transporters_Homo sapiens_hsa02010	0.37054518
72	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.35051962
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.33499297
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.32428896
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30328254
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29607651
77	Salivary secretion_Homo sapiens_hsa04970	0.29083047
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.28066107
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.27401316
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.27352813
81	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.27209909
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26888673
83	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.26243014
84	Histidine metabolism_Homo sapiens_hsa00340	0.26183581
85	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.25914749
86	Choline metabolism in cancer_Homo sapiens_hsa05231	0.24916741
87	Lysosome_Homo sapiens_hsa04142	0.24901783
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.24231384
89	Bladder cancer_Homo sapiens_hsa05219	0.24035495
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.20183420
91	Phagosome_Homo sapiens_hsa04145	0.18875354
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.17537008
93	Graft-versus-host disease_Homo sapiens_hsa05332	0.12692607
94	Amoebiasis_Homo sapiens_hsa05146	0.11289914
95	Focal adhesion_Homo sapiens_hsa04510	0.09882883
96	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.09449564
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.09147089
98	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.08813743
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.08379012
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.06289149

TMEM207

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »