Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.50417072 |
2 | ATP synthesis coupled proton transport (GO:0015986) | 6.18871560 |
3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.18871560 |
4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.62377658 |
5 | ribosomal small subunit biogenesis (GO:0042274) | 5.37082692 |
6 | ribosomal small subunit assembly (GO:0000028) | 5.15522437 |
7 | respiratory electron transport chain (GO:0022904) | 4.98694875 |
8 | cotranslational protein targeting to membrane (GO:0006613) | 4.89667984 |
9 | electron transport chain (GO:0022900) | 4.86492100 |
10 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.85783980 |
11 | protein targeting to ER (GO:0045047) | 4.80379295 |
12 | viral transcription (GO:0019083) | 4.79576320 |
13 | chaperone-mediated protein transport (GO:0072321) | 4.70749873 |
14 | proteasome assembly (GO:0043248) | 4.70027389 |
15 | protein localization to endoplasmic reticulum (GO:0070972) | 4.67158438 |
16 | translational termination (GO:0006415) | 4.65388993 |
17 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.56926407 |
18 | protein neddylation (GO:0045116) | 4.43098506 |
19 | signal peptide processing (GO:0006465) | 4.39260101 |
20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.36690658 |
21 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.36690658 |
22 | NADH dehydrogenase complex assembly (GO:0010257) | 4.36690658 |
23 | rRNA modification (GO:0000154) | 4.36377571 |
24 | fatty acid elongation (GO:0030497) | 4.25357556 |
25 | DNA deamination (GO:0045006) | 4.21698706 |
26 | protein complex biogenesis (GO:0070271) | 4.12850573 |
27 | maturation of SSU-rRNA (GO:0030490) | 4.09434499 |
28 | GTP biosynthetic process (GO:0006183) | 4.00175419 |
29 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.89365406 |
30 | translational elongation (GO:0006414) | 3.89051813 |
31 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.87297180 |
32 | termination of RNA polymerase III transcription (GO:0006386) | 3.87297180 |
33 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.76714389 |
34 | translation (GO:0006412) | 3.76608005 |
35 | regulation of mitochondrial translation (GO:0070129) | 3.75046192 |
36 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.70120890 |
37 | viral life cycle (GO:0019058) | 3.69638855 |
38 | ribosomal large subunit biogenesis (GO:0042273) | 3.68744571 |
39 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.68344026 |
40 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.67076733 |
41 | cellular protein complex disassembly (GO:0043624) | 3.64942987 |
42 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.64081398 |
43 | ATP biosynthetic process (GO:0006754) | 3.62179914 |
44 | mannosylation (GO:0097502) | 3.59017301 |
45 | rRNA methylation (GO:0031167) | 3.58365483 |
46 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.57444039 |
47 | GPI anchor biosynthetic process (GO:0006506) | 3.53691160 |
48 | respiratory chain complex IV assembly (GO:0008535) | 3.53495245 |
49 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.52986167 |
50 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.51617553 |
51 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.49871035 |
52 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.49750202 |
53 | platelet dense granule organization (GO:0060155) | 3.49448435 |
54 | protein targeting to mitochondrion (GO:0006626) | 3.47183058 |
55 | axon ensheathment in central nervous system (GO:0032291) | 3.46496686 |
56 | central nervous system myelination (GO:0022010) | 3.46496686 |
57 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.44851914 |
58 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.44306939 |
59 | GDP-mannose metabolic process (GO:0019673) | 3.38060436 |
60 | intracellular protein transmembrane import (GO:0044743) | 3.37000016 |
61 | translational initiation (GO:0006413) | 3.36924831 |
62 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.36218677 |
63 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.36218677 |
64 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.36122111 |
65 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.36122111 |
66 | pseudouridine synthesis (GO:0001522) | 3.34305951 |
67 | UTP biosynthetic process (GO:0006228) | 3.33195222 |
68 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.33043962 |
69 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.33043962 |
70 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.33043962 |
71 | mitochondrial transport (GO:0006839) | 3.31696714 |
72 | establishment of protein localization to mitochondrion (GO:0072655) | 3.30889908 |
73 | positive regulation of ligase activity (GO:0051351) | 3.30088559 |
74 | 7-methylguanosine mRNA capping (GO:0006370) | 3.28334359 |
75 | L-methionine salvage (GO:0071267) | 3.26857554 |
76 | L-methionine biosynthetic process (GO:0071265) | 3.26857554 |
77 | amino acid salvage (GO:0043102) | 3.26857554 |
78 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.26108513 |
79 | negative regulation of ligase activity (GO:0051352) | 3.26108513 |
80 | cholesterol biosynthetic process (GO:0006695) | 3.24451260 |
81 | 7-methylguanosine RNA capping (GO:0009452) | 3.22702748 |
82 | RNA capping (GO:0036260) | 3.22702748 |
83 | protein targeting to membrane (GO:0006612) | 3.21774386 |
84 | inner mitochondrial membrane organization (GO:0007007) | 3.21367367 |
85 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.21206906 |
86 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.20748325 |
87 | hydrogen ion transmembrane transport (GO:1902600) | 3.19426518 |
88 | nucleotide transmembrane transport (GO:1901679) | 3.18906606 |
89 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.17548425 |
90 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.17548425 |
91 | protein maturation by protein folding (GO:0022417) | 3.17183167 |
92 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.16095482 |
93 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.14626032 |
94 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.14135764 |
95 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.13584561 |
96 | cullin deneddylation (GO:0010388) | 3.13571727 |
97 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.13414123 |
98 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.11484100 |
99 | CTP biosynthetic process (GO:0006241) | 3.08371415 |
100 | CTP metabolic process (GO:0046036) | 3.08371415 |
101 | GPI anchor metabolic process (GO:0006505) | 3.07738401 |
102 | cytochrome complex assembly (GO:0017004) | 3.04848294 |
103 | protein localization to mitochondrion (GO:0070585) | 3.02221665 |
104 | establishment of integrated proviral latency (GO:0075713) | 3.01290058 |
105 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.00657929 |
106 | establishment of viral latency (GO:0019043) | 2.99766839 |
107 | proton transport (GO:0015992) | 2.99626319 |
108 | regulation of cellular amine metabolic process (GO:0033238) | 2.99432087 |
109 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.97569706 |
110 | positive regulation of cell cycle arrest (GO:0071158) | 2.96892335 |
111 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.96237368 |
112 | protein-cofactor linkage (GO:0018065) | 2.95412130 |
113 | cellular component biogenesis (GO:0044085) | 2.95109266 |
114 | base-excision repair, AP site formation (GO:0006285) | 2.94918564 |
115 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.94443131 |
116 | peptidyl-histidine modification (GO:0018202) | 2.94300781 |
117 | hydrogen transport (GO:0006818) | 2.93157402 |
118 | UTP metabolic process (GO:0046051) | 2.93098009 |
119 | protein complex disassembly (GO:0043241) | 2.93022231 |
120 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.92145958 |
121 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.91427868 |
122 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.91427868 |
123 | oxidative phosphorylation (GO:0006119) | 2.91097579 |
124 | protein deneddylation (GO:0000338) | 2.90222326 |
125 | aerobic respiration (GO:0009060) | 2.88188507 |
126 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 2.86965196 |
127 | L-phenylalanine metabolic process (GO:0006558) | 2.86965196 |
128 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.86641521 |
129 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.86088465 |
130 | regulation of ligase activity (GO:0051340) | 2.84242931 |
131 | aldehyde catabolic process (GO:0046185) | 2.82140520 |
Rank | Gene Set | Z-score |
---|---|---|
1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.85245940 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.29351626 |
3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.79038744 |
4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.31863334 |
5 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.21970746 |
6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.16785415 |
7 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.54015679 |
8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.42335194 |
9 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.41619757 |
10 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.38407242 |
11 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.27371629 |
12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.12328705 |
13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.07211308 |
14 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.05776954 |
15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.05616752 |
16 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.90918172 |
17 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.89586365 |
18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.70124567 |
19 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.67761354 |
20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.57355593 |
21 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.28511497 |
22 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.16509329 |
23 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.16402662 |
24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.13538629 |
25 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.08164544 |
26 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.01645675 |
27 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.95048888 |
28 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.94524758 |
29 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.89002506 |
30 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.87070562 |
31 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.81831545 |
32 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79675146 |
33 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.77066090 |
34 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.76533959 |
35 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.75684638 |
36 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.68229452 |
37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.67778419 |
38 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.62413657 |
39 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.55477475 |
40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.53127057 |
41 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.52980504 |
42 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.47853515 |
43 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.44585786 |
44 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.43283240 |
45 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.42145008 |
46 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.37417210 |
47 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.35987837 |
48 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.35964990 |
49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35764761 |
50 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.24040130 |
51 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.22059841 |
52 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.21450415 |
53 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.19149352 |
54 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.18821281 |
55 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.18632582 |
56 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.14233708 |
57 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.11186363 |
58 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.10056955 |
59 | VDR_22108803_ChIP-Seq_LS180_Human | 1.08874017 |
60 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.08012890 |
61 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.07307283 |
62 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.06451226 |
63 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.04904180 |
64 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.04351805 |
65 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.04051089 |
66 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.99416094 |
67 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.97372504 |
68 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.96663926 |
69 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96610027 |
70 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96510193 |
71 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.96227687 |
72 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.95921296 |
73 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.95424130 |
74 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.95418371 |
75 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.94764742 |
76 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.93563341 |
77 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.92610729 |
78 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.92519983 |
79 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.92213436 |
80 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.92155643 |
81 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.90976289 |
82 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.89120243 |
83 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.88986893 |
84 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.85211106 |
85 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.84829506 |
86 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.84442944 |
87 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.83563848 |
88 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.82953207 |
89 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.80601639 |
90 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80594724 |
91 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.80558153 |
92 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.80481415 |
93 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.80481415 |
94 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.79927624 |
95 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.79820622 |
96 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.79788474 |
97 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.79126064 |
98 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.77893049 |
99 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.77794571 |
100 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.76589616 |
101 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.76175093 |
102 | GATA1_22025678_ChIP-Seq_K562_Human | 0.75722357 |
103 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.75425298 |
104 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.75047633 |
105 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.74484180 |
106 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.71759528 |
107 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.71652028 |
108 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.71042327 |
109 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.69763344 |
110 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.69310048 |
111 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.69248253 |
112 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.68719809 |
113 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.68614643 |
114 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.68377747 |
115 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.68268486 |
116 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.68181956 |
117 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.68174735 |
118 | AR_20517297_ChIP-Seq_VCAP_Human | 0.67356498 |
119 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.67353669 |
120 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.66802711 |
121 | EWS_26573619_Chip-Seq_HEK293_Human | 0.66311648 |
122 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.66283677 |
123 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.66067983 |
124 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.65953563 |
125 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.63777933 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009379_abnormal_foot_pigmentation | 4.34697450 |
2 | MP0003806_abnormal_nucleotide_metabolis | 3.86441711 |
3 | MP0001529_abnormal_vocalization | 3.17559656 |
4 | MP0002254_reproductive_system_inflammat | 3.00661142 |
5 | MP0001905_abnormal_dopamine_level | 2.84593402 |
6 | MP0004147_increased_porphyrin_level | 2.79746306 |
7 | MP0002139_abnormal_hepatobiliary_system | 2.76696072 |
8 | MP0003186_abnormal_redox_activity | 2.75380493 |
9 | MP0000920_abnormal_myelination | 2.62805261 |
10 | MP0008875_abnormal_xenobiotic_pharmacok | 2.57128488 |
11 | MP0002837_dystrophic_cardiac_calcinosis | 2.56911672 |
12 | MP0001986_abnormal_taste_sensitivity | 2.48700428 |
13 | MP0002638_abnormal_pupillary_reflex | 2.39417977 |
14 | MP0003136_yellow_coat_color | 2.35565352 |
15 | MP0006036_abnormal_mitochondrial_physio | 2.06055387 |
16 | MP0004142_abnormal_muscle_tone | 1.98045374 |
17 | MP0000372_irregular_coat_pigmentation | 1.97504741 |
18 | MP0005408_hypopigmentation | 1.96731636 |
19 | MP0008260_abnormal_autophagy | 1.92685614 |
20 | MP0004019_abnormal_vitamin_homeostasis | 1.87668358 |
21 | MP0003656_abnormal_erythrocyte_physiolo | 1.86258528 |
22 | MP0003880_abnormal_central_pattern | 1.85079237 |
23 | MP0005171_absent_coat_pigmentation | 1.79184067 |
24 | MP0005379_endocrine/exocrine_gland_phen | 1.79123459 |
25 | MP0002132_abnormal_respiratory_system | 1.77238495 |
26 | MP0002148_abnormal_hypersensitivity_rea | 1.69567536 |
27 | MP0005174_abnormal_tail_pigmentation | 1.69077396 |
28 | MP0009840_abnormal_foam_cell | 1.68805248 |
29 | MP0006035_abnormal_mitochondrial_morpho | 1.64823859 |
30 | MP0003693_abnormal_embryo_hatching | 1.62435181 |
31 | MP0009333_abnormal_splenocyte_physiolog | 1.62383615 |
32 | MP0005409_darkened_coat_color | 1.61372940 |
33 | MP0000015_abnormal_ear_pigmentation | 1.57885200 |
34 | MP0001756_abnormal_urination | 1.55814108 |
35 | MP0005365_abnormal_bile_salt | 1.55412807 |
36 | MP0009785_altered_susceptibility_to | 1.54052708 |
37 | MP0005645_abnormal_hypothalamus_physiol | 1.53722029 |
38 | MP0003724_increased_susceptibility_to | 1.53663563 |
39 | MP0002938_white_spotting | 1.50411368 |
40 | MP0005075_abnormal_melanosome_morpholog | 1.50223645 |
41 | MP0006082_CNS_inflammation | 1.49342390 |
42 | MP0001542_abnormal_bone_strength | 1.49295890 |
43 | MP0003718_maternal_effect | 1.44919800 |
44 | MP0001485_abnormal_pinna_reflex | 1.41594443 |
45 | MP0004381_abnormal_hair_follicle | 1.40494847 |
46 | MP0005058_abnormal_lysosome_morphology | 1.39221416 |
47 | MP0010386_abnormal_urinary_bladder | 1.38810220 |
48 | MP0004742_abnormal_vestibular_system | 1.36173659 |
49 | MP0005451_abnormal_body_composition | 1.35295094 |
50 | MP0004133_heterotaxia | 1.33554303 |
51 | MP0000358_abnormal_cell_content/ | 1.33389476 |
52 | MP0003195_calcinosis | 1.31826121 |
53 | MP0003011_delayed_dark_adaptation | 1.29181897 |
54 | MP0001835_abnormal_antigen_presentation | 1.28522653 |
55 | MP0003123_paternal_imprinting | 1.28141907 |
56 | MP0005671_abnormal_response_to | 1.28087890 |
57 | MP0006276_abnormal_autonomic_nervous | 1.26940388 |
58 | MP0009697_abnormal_copulation | 1.26567048 |
59 | MP0002876_abnormal_thyroid_physiology | 1.24839539 |
60 | MP0001764_abnormal_homeostasis | 1.24750632 |
61 | MP0002909_abnormal_adrenal_gland | 1.23535004 |
62 | MP0002163_abnormal_gland_morphology | 1.23314311 |
63 | MP0005636_abnormal_mineral_homeostasis | 1.23245567 |
64 | MP0002090_abnormal_vision | 1.21454818 |
65 | MP0002693_abnormal_pancreas_physiology | 1.20496754 |
66 | MP0005000_abnormal_immune_tolerance | 1.20423502 |
67 | MP0005025_abnormal_response_to | 1.19566692 |
68 | MP0008057_abnormal_DNA_replication | 1.19219491 |
69 | MP0009046_muscle_twitch | 1.17824961 |
70 | MP0005085_abnormal_gallbladder_physiolo | 1.17621625 |
71 | MP0008995_early_reproductive_senescence | 1.16327064 |
72 | MP0001853_heart_inflammation | 1.12403834 |
73 | MP0001944_abnormal_pancreas_morphology | 1.10567137 |
74 | MP0005646_abnormal_pituitary_gland | 1.10390450 |
75 | MP0002277_abnormal_respiratory_mucosa | 1.06511367 |
76 | MP0001188_hyperpigmentation | 1.06462700 |
77 | MP0001968_abnormal_touch/_nociception | 1.06334273 |
78 | MP0004043_abnormal_pH_regulation | 1.06212610 |
79 | MP0002102_abnormal_ear_morphology | 1.05042281 |
80 | MP0008932_abnormal_embryonic_tissue | 1.04845114 |
81 | MP0002736_abnormal_nociception_after | 1.04022079 |
82 | MP0003329_amyloid_beta_deposits | 1.02541913 |
83 | MP0000516_abnormal_urinary_system | 1.02176461 |
84 | MP0005367_renal/urinary_system_phenotyp | 1.02176461 |
85 | MP0008058_abnormal_DNA_repair | 1.02108051 |
86 | MP0004957_abnormal_blastocyst_morpholog | 1.01960540 |
87 | MP0002272_abnormal_nervous_system | 1.00730781 |
88 | MP0002419_abnormal_innate_immunity | 0.99566889 |
89 | MP0005084_abnormal_gallbladder_morpholo | 0.98567291 |
90 | MP0005319_abnormal_enzyme/_coenzyme | 0.97924091 |
91 | MP0001727_abnormal_embryo_implantation | 0.97234608 |
92 | MP0004134_abnormal_chest_morphology | 0.95593117 |
93 | MP0005332_abnormal_amino_acid | 0.95591879 |
94 | MP0001666_abnormal_nutrient_absorption | 0.94449352 |
95 | MP0008789_abnormal_olfactory_epithelium | 0.94046725 |
96 | MP0005410_abnormal_fertilization | 0.93651389 |
97 | MP0010329_abnormal_lipoprotein_level | 0.93477062 |
98 | MP0008007_abnormal_cellular_replicative | 0.93293983 |
99 | MP0002229_neurodegeneration | 0.92367494 |
100 | MP0002095_abnormal_skin_pigmentation | 0.91792124 |
101 | MP0005083_abnormal_biliary_tract | 0.89966744 |
102 | MP0006072_abnormal_retinal_apoptosis | 0.88831147 |
103 | MP0005551_abnormal_eye_electrophysiolog | 0.88710221 |
104 | MP0000538_abnormal_urinary_bladder | 0.88284768 |
105 | MP0002723_abnormal_immune_serum | 0.84191257 |
106 | MP0003690_abnormal_glial_cell | 0.83538896 |
107 | MP0005389_reproductive_system_phenotype | 0.83234527 |
108 | MP0003634_abnormal_glial_cell | 0.82912959 |
109 | MP0001661_extended_life_span | 0.82809991 |
110 | MP0002295_abnormal_pulmonary_circulatio | 0.82255072 |
111 | MP0003950_abnormal_plasma_membrane | 0.81961309 |
112 | MP0001664_abnormal_digestion | 0.81632377 |
113 | MP0001984_abnormal_olfaction | 0.80528631 |
114 | MP0001919_abnormal_reproductive_system | 0.80208586 |
115 | MP0008469_abnormal_protein_level | 0.80004939 |
116 | MP0000639_abnormal_adrenal_gland | 0.78136303 |
117 | MP0003121_genomic_imprinting | 0.77931111 |
118 | MP0006292_abnormal_olfactory_placode | 0.77926367 |
119 | MP0001963_abnormal_hearing_physiology | 0.77315749 |
120 | MP0009745_abnormal_behavioral_response | 0.76854402 |
121 | MP0001324_abnormal_eye_pigmentation | 0.76731981 |
122 | MP0008872_abnormal_physiological_respon | 0.75960589 |
123 | MP0005253_abnormal_eye_physiology | 0.74481588 |
124 | MP0005376_homeostasis/metabolism_phenot | 0.73916815 |
125 | MP0000681_abnormal_thyroid_gland | 0.71921513 |
126 | MP0009765_abnormal_xenobiotic_induced | 0.71588185 |
127 | MP0002210_abnormal_sex_determination | 0.70813491 |
128 | MP0002160_abnormal_reproductive_system | 0.70009291 |
129 | MP0005164_abnormal_response_to | 0.69787280 |
130 | MP0002734_abnormal_mechanical_nocicepti | 0.69403455 |
131 | MP0005360_urolithiasis | 0.68709961 |
132 | MP0003786_premature_aging | 0.68303921 |
133 | MP0003436_decreased_susceptibility_to | 0.67904738 |
134 | MP0008877_abnormal_DNA_methylation | 0.67496496 |
135 | MP0002420_abnormal_adaptive_immunity | 0.67392338 |
136 | MP0009643_abnormal_urine_homeostasis | 0.67381936 |
137 | MP0002078_abnormal_glucose_homeostasis | 0.67205099 |
138 | MP0001819_abnormal_immune_cell | 0.66180281 |
139 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.66028187 |
140 | MP0003953_abnormal_hormone_level | 0.65287474 |
141 | MP0000604_amyloidosis | 0.64495745 |
142 | MP0003941_abnormal_skin_development | 0.64337152 |
143 | MP0002452_abnormal_antigen_presenting | 0.63418759 |
144 | MP0006054_spinal_hemorrhage | 0.63302753 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 5.76055475 |
2 | Mitochondrial inheritance (HP:0001427) | 5.22581682 |
3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.14115454 |
4 | Acute encephalopathy (HP:0006846) | 4.89928985 |
5 | Progressive macrocephaly (HP:0004481) | 4.68877098 |
6 | Hepatocellular necrosis (HP:0001404) | 4.59999962 |
7 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.51648507 |
8 | Increased CSF lactate (HP:0002490) | 4.31421739 |
9 | Abnormal number of erythroid precursors (HP:0012131) | 4.23397442 |
10 | Hepatic necrosis (HP:0002605) | 4.17239164 |
11 | Increased hepatocellular lipid droplets (HP:0006565) | 4.15200930 |
12 | Renal Fanconi syndrome (HP:0001994) | 4.12155231 |
13 | 3-Methylglutaconic aciduria (HP:0003535) | 4.01493920 |
14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.71089400 |
15 | Increased serum pyruvate (HP:0003542) | 3.69903401 |
16 | Abnormality of glycolysis (HP:0004366) | 3.69903401 |
17 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.57595752 |
18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.53301970 |
19 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.53301970 |
20 | Parakeratosis (HP:0001036) | 3.44600382 |
21 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.43363112 |
22 | Reticulocytopenia (HP:0001896) | 3.43093261 |
23 | Type I transferrin isoform profile (HP:0003642) | 3.39557202 |
24 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.34205128 |
25 | Cerebral edema (HP:0002181) | 3.31096663 |
26 | Respiratory failure (HP:0002878) | 3.17688317 |
27 | Increased serum lactate (HP:0002151) | 3.16312236 |
28 | Leukodystrophy (HP:0002415) | 3.09367996 |
29 | Macrocytic anemia (HP:0001972) | 3.08696366 |
30 | Increased intramyocellular lipid droplets (HP:0012240) | 3.06860540 |
31 | Lactic acidosis (HP:0003128) | 3.02840428 |
32 | Exertional dyspnea (HP:0002875) | 2.98702647 |
33 | Optic disc pallor (HP:0000543) | 2.89699773 |
34 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.84341604 |
35 | Exercise intolerance (HP:0003546) | 2.83351350 |
36 | Cerebral hypomyelination (HP:0006808) | 2.78854198 |
37 | Abnormality of renal resorption (HP:0011038) | 2.76560829 |
38 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.73211353 |
39 | Hypothermia (HP:0002045) | 2.66555272 |
40 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.66081492 |
41 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.66081492 |
42 | Abnormal protein glycosylation (HP:0012346) | 2.66081492 |
43 | Abnormal glycosylation (HP:0012345) | 2.66081492 |
44 | Hypoglycemic coma (HP:0001325) | 2.63205458 |
45 | Pallor (HP:0000980) | 2.57355217 |
46 | Increased muscle lipid content (HP:0009058) | 2.54874247 |
47 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.48320618 |
48 | Respiratory difficulties (HP:0002880) | 2.45023706 |
49 | Aplastic anemia (HP:0001915) | 2.42297903 |
50 | Glycosuria (HP:0003076) | 2.29745917 |
51 | Abnormality of urine glucose concentration (HP:0011016) | 2.29745917 |
52 | Hypokinesia (HP:0002375) | 2.25746714 |
53 | Vacuolated lymphocytes (HP:0001922) | 2.22032578 |
54 | Hypoglycemic seizures (HP:0002173) | 2.21476760 |
55 | Reduced antithrombin III activity (HP:0001976) | 2.20989856 |
56 | CNS demyelination (HP:0007305) | 2.19154588 |
57 | Hyperglycinemia (HP:0002154) | 2.15904903 |
58 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.15084932 |
59 | Large for gestational age (HP:0001520) | 2.14131058 |
60 | Microvesicular hepatic steatosis (HP:0001414) | 2.12435680 |
61 | Spastic paraparesis (HP:0002313) | 2.10780363 |
62 | Abnormality of midbrain morphology (HP:0002418) | 2.06988586 |
63 | Molar tooth sign on MRI (HP:0002419) | 2.06988586 |
64 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.05768313 |
65 | Degeneration of anterior horn cells (HP:0002398) | 2.05482575 |
66 | Abnormality of the anterior horn cell (HP:0006802) | 2.05482575 |
67 | Congenital, generalized hypertrichosis (HP:0004540) | 2.04870533 |
68 | Generalized aminoaciduria (HP:0002909) | 2.03179720 |
69 | Abnormality of methionine metabolism (HP:0010901) | 2.03120966 |
70 | Hepatosplenomegaly (HP:0001433) | 2.01653560 |
71 | Ketoacidosis (HP:0001993) | 2.01164800 |
72 | Oral leukoplakia (HP:0002745) | 2.00356822 |
73 | Prolonged neonatal jaundice (HP:0006579) | 1.99712583 |
74 | Irregular epiphyses (HP:0010582) | 1.98156830 |
75 | Lethargy (HP:0001254) | 1.98018349 |
76 | Sensory axonal neuropathy (HP:0003390) | 1.97410099 |
77 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.97223180 |
78 | Pancreatic fibrosis (HP:0100732) | 1.96240617 |
79 | Abnormality of placental membranes (HP:0011409) | 1.96033506 |
80 | Amniotic constriction ring (HP:0009775) | 1.96033506 |
81 | Patchy hypopigmentation of hair (HP:0011365) | 1.93708868 |
82 | Hyperphosphaturia (HP:0003109) | 1.90684688 |
83 | Pancreatic cysts (HP:0001737) | 1.90662451 |
84 | Hypoplasia of the uterus (HP:0000013) | 1.89269979 |
85 | Abnormal pupillary function (HP:0007686) | 1.85938631 |
86 | Methylmalonic aciduria (HP:0012120) | 1.83369286 |
87 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.83203929 |
88 | Abnormality of alanine metabolism (HP:0010916) | 1.83203929 |
89 | Hyperalaninemia (HP:0003348) | 1.83203929 |
90 | Poor suck (HP:0002033) | 1.83044531 |
91 | Nausea (HP:0002018) | 1.82533074 |
92 | Testicular atrophy (HP:0000029) | 1.82527173 |
93 | Abnormal hemoglobin (HP:0011902) | 1.81871870 |
94 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.81308990 |
95 | X-linked dominant inheritance (HP:0001423) | 1.81101567 |
96 | Methylmalonic acidemia (HP:0002912) | 1.80826306 |
97 | Abnormality of vitamin B metabolism (HP:0004340) | 1.79681813 |
98 | Abnormality of serum amino acid levels (HP:0003112) | 1.79250729 |
99 | Sparse eyelashes (HP:0000653) | 1.79211946 |
100 | True hermaphroditism (HP:0010459) | 1.79169455 |
101 | Poor head control (HP:0002421) | 1.78786707 |
102 | CNS hypomyelination (HP:0003429) | 1.78752636 |
103 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.78551389 |
104 | Medial flaring of the eyebrow (HP:0010747) | 1.78428743 |
105 | Rough bone trabeculation (HP:0100670) | 1.76694729 |
106 | Ketosis (HP:0001946) | 1.76626009 |
107 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.75168769 |
108 | Symptomatic seizures (HP:0011145) | 1.74233071 |
109 | Pancytopenia (HP:0001876) | 1.74173607 |
110 | Stenosis of the external auditory canal (HP:0000402) | 1.73281204 |
111 | Delayed CNS myelination (HP:0002188) | 1.72812407 |
112 | Retinal dysplasia (HP:0007973) | 1.71953955 |
113 | Gliosis (HP:0002171) | 1.70895220 |
114 | Autoamputation (HP:0001218) | 1.70014364 |
115 | Emotional lability (HP:0000712) | 1.69045783 |
116 | Renal tubular dysfunction (HP:0000124) | 1.68899646 |
117 | Hyperglycemia (HP:0003074) | 1.68698689 |
118 | Purpura (HP:0000979) | 1.67743948 |
119 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.66116742 |
120 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.66116742 |
121 | Brushfield spots (HP:0001088) | 1.61896889 |
122 | Opisthotonus (HP:0002179) | 1.58461164 |
123 | White forelock (HP:0002211) | 1.58301539 |
124 | Abnormality of macrophages (HP:0004311) | 1.57849220 |
125 | Blindness (HP:0000618) | 1.57222146 |
126 | Neuroendocrine neoplasm (HP:0100634) | 1.56709871 |
127 | Steatorrhea (HP:0002570) | 1.53845763 |
128 | Dicarboxylic aciduria (HP:0003215) | 1.52880171 |
129 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.52880171 |
130 | Abnormal urine phosphate concentration (HP:0012599) | 1.52448651 |
131 | Abnormality of secondary sexual hair (HP:0009888) | 1.51525274 |
132 | Abnormality of the axillary hair (HP:0100134) | 1.51525274 |
133 | Type 2 muscle fiber atrophy (HP:0003554) | 1.50601556 |
134 | Vomiting (HP:0002013) | 1.49985608 |
135 | Petechiae (HP:0000967) | 1.49692711 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 4.48553281 |
2 | NME2 | 3.91725443 |
3 | STK16 | 3.86084553 |
4 | PBK | 3.32171359 |
5 | STK39 | 2.76719129 |
6 | TNIK | 2.65569600 |
7 | PDK2 | 2.56068563 |
8 | MST4 | 2.42386514 |
9 | CDK19 | 2.36019473 |
10 | EIF2AK3 | 2.31111779 |
11 | NME1 | 2.22634539 |
12 | VRK1 | 2.19749984 |
13 | PIM2 | 2.18504005 |
14 | BUB1 | 2.10857041 |
15 | OXSR1 | 2.08825935 |
16 | EIF2AK1 | 2.08743580 |
17 | MUSK | 1.97807236 |
18 | TRIM28 | 1.93314032 |
19 | WNK3 | 1.85030516 |
20 | MAP3K12 | 1.79432592 |
21 | ARAF | 1.72764041 |
22 | MAP4K2 | 1.72117900 |
23 | MAPKAPK5 | 1.71901640 |
24 | BMPR1B | 1.71214310 |
25 | FRK | 1.66796463 |
26 | IRAK3 | 1.56382231 |
27 | WEE1 | 1.55619165 |
28 | BCR | 1.52819383 |
29 | BCKDK | 1.49916444 |
30 | NUAK1 | 1.45239983 |
31 | NEK1 | 1.44813482 |
32 | SRPK1 | 1.44038324 |
33 | CASK | 1.42301163 |
34 | WNK4 | 1.38838970 |
35 | TLK1 | 1.36607057 |
36 | ABL2 | 1.29494557 |
37 | IRAK4 | 1.27142372 |
38 | LIMK1 | 1.25326319 |
39 | PLK3 | 1.24935638 |
40 | CSNK1G3 | 1.24075811 |
41 | GRK7 | 1.12734337 |
42 | TESK2 | 1.10858899 |
43 | DYRK2 | 1.08721197 |
44 | DAPK1 | 1.05296597 |
45 | ILK | 1.02777378 |
46 | ADRBK2 | 1.01961019 |
47 | MYLK | 0.98341930 |
48 | BRAF | 0.97370207 |
49 | TAF1 | 0.97263123 |
50 | PAK4 | 0.96632379 |
51 | MKNK1 | 0.95261573 |
52 | INSRR | 0.89303435 |
53 | CCNB1 | 0.89283608 |
54 | PRKCI | 0.88803629 |
55 | KIT | 0.86122117 |
56 | TXK | 0.83933919 |
57 | CSNK1G1 | 0.83515838 |
58 | IRAK2 | 0.82804443 |
59 | BRSK2 | 0.82787707 |
60 | PHKG2 | 0.80782220 |
61 | PHKG1 | 0.80782220 |
62 | CAMK2B | 0.80341141 |
63 | NEK6 | 0.80286410 |
64 | PLK1 | 0.80258536 |
65 | BLK | 0.80000859 |
66 | TSSK6 | 0.79291569 |
67 | DAPK3 | 0.79278493 |
68 | MAP2K7 | 0.79237324 |
69 | BRSK1 | 0.78025810 |
70 | RPS6KA5 | 0.77251744 |
71 | AURKA | 0.75939219 |
72 | PAK3 | 0.75242980 |
73 | PIK3CG | 0.73140747 |
74 | EIF2AK2 | 0.72747236 |
75 | KDR | 0.71756526 |
76 | TEC | 0.70010709 |
77 | PRKCG | 0.68099286 |
78 | MAP3K11 | 0.67902321 |
79 | MKNK2 | 0.67799329 |
80 | CLK1 | 0.66977267 |
81 | LRRK2 | 0.66853456 |
82 | BMPR2 | 0.66262643 |
83 | ACVR1B | 0.64965936 |
84 | IKBKB | 0.64792994 |
85 | TTK | 0.62275388 |
86 | CSNK1A1L | 0.62137511 |
87 | MAP3K14 | 0.61190153 |
88 | UHMK1 | 0.60933445 |
89 | PLK4 | 0.59916789 |
90 | MAPK15 | 0.58054139 |
91 | GRK1 | 0.58030600 |
92 | CAMK2D | 0.57846640 |
93 | LYN | 0.57706871 |
94 | CSNK2A1 | 0.57598693 |
95 | ZAK | 0.57303290 |
96 | CSNK1G2 | 0.57140070 |
97 | IRAK1 | 0.56585880 |
98 | CAMK2G | 0.56355020 |
99 | MAPK13 | 0.55807662 |
100 | YES1 | 0.55540681 |
101 | PKN1 | 0.55530505 |
102 | MAP4K1 | 0.54612929 |
103 | PLK2 | 0.54355547 |
104 | SYK | 0.51448693 |
105 | MAP3K3 | 0.51361533 |
106 | CAMKK2 | 0.50461453 |
107 | CSNK2A2 | 0.50182757 |
108 | DYRK3 | 0.49510451 |
109 | STK4 | 0.48820660 |
110 | MET | 0.48192762 |
111 | TBK1 | 0.46741722 |
112 | PINK1 | 0.45759641 |
113 | TAOK2 | 0.45549125 |
114 | FGFR2 | 0.44573646 |
115 | AURKB | 0.43699066 |
116 | ERBB3 | 0.42206578 |
117 | PRKCE | 0.41813365 |
118 | CDK3 | 0.41375671 |
119 | CDC7 | 0.40469421 |
120 | MAPKAPK3 | 0.40141859 |
121 | TESK1 | 0.39975349 |
122 | MAPK4 | 0.39138834 |
123 | MST1R | 0.38090987 |
124 | SIK3 | 0.37698912 |
125 | CSNK1A1 | 0.37460330 |
126 | CHEK2 | 0.36996573 |
127 | BTK | 0.36975536 |
128 | GRK5 | 0.36733821 |
129 | PAK1 | 0.35569498 |
130 | PRPF4B | 0.34837821 |
131 | OBSCN | 0.34533832 |
132 | PRKCQ | 0.33754752 |
133 | ADRBK1 | 0.33223349 |
134 | EPHB1 | 0.32149581 |
135 | TRPM7 | 0.31670282 |
136 | FER | 0.30054160 |
137 | MAP2K6 | 0.28901517 |
138 | PRKG2 | 0.27861501 |
139 | CDK8 | 0.27845821 |
140 | PRKACA | 0.27822221 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.59474918 |
2 | Ribosome_Homo sapiens_hsa03010 | 4.42710786 |
3 | Protein export_Homo sapiens_hsa03060 | 4.09747190 |
4 | Proteasome_Homo sapiens_hsa03050 | 4.06813467 |
5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.74182058 |
6 | RNA polymerase_Homo sapiens_hsa03020 | 3.00300380 |
7 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.72335286 |
8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.71670846 |
9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.58547795 |
10 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.41012448 |
11 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.27985586 |
12 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.16026352 |
13 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.94148886 |
14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.82298528 |
15 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.71784002 |
16 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.67304482 |
17 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.62033437 |
18 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.61155652 |
19 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.58981185 |
20 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.55012956 |
21 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.42434456 |
22 | DNA replication_Homo sapiens_hsa03030 | 1.39024494 |
23 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.28278876 |
24 | Mismatch repair_Homo sapiens_hsa03430 | 1.24133210 |
25 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.23623206 |
26 | Homologous recombination_Homo sapiens_hsa03440 | 1.21599469 |
27 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.19479704 |
28 | Spliceosome_Homo sapiens_hsa03040 | 1.16430709 |
29 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.16415914 |
30 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.16037227 |
31 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.15878243 |
32 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.15529973 |
33 | Basal transcription factors_Homo sapiens_hsa03022 | 1.07793034 |
34 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.05570616 |
35 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.01655488 |
36 | Purine metabolism_Homo sapiens_hsa00230 | 1.00721252 |
37 | Metabolic pathways_Homo sapiens_hsa01100 | 0.98276370 |
38 | Histidine metabolism_Homo sapiens_hsa00340 | 0.97057319 |
39 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.96179465 |
40 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.95473138 |
41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.93573472 |
42 | Sulfur relay system_Homo sapiens_hsa04122 | 0.92610815 |
43 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.91039093 |
44 | Peroxisome_Homo sapiens_hsa04146 | 0.89158830 |
45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.85940817 |
46 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.85450263 |
47 | Base excision repair_Homo sapiens_hsa03410 | 0.84607880 |
48 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84075819 |
49 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.83736023 |
50 | Other glycan degradation_Homo sapiens_hsa00511 | 0.83513514 |
51 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.81731782 |
52 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.80941137 |
53 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.80835602 |
54 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.79975390 |
55 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.76775568 |
56 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.75620705 |
57 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.71968240 |
58 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.71251015 |
59 | Carbon metabolism_Homo sapiens_hsa01200 | 0.67437206 |
60 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.66625330 |
61 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.66451882 |
62 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.65495379 |
63 | Allograft rejection_Homo sapiens_hsa05330 | 0.65136780 |
64 | Mineral absorption_Homo sapiens_hsa04978 | 0.64265604 |
65 | Phagosome_Homo sapiens_hsa04145 | 0.63910711 |
66 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.63044715 |
67 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.62163985 |
68 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.61385678 |
69 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.59370989 |
70 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.59323629 |
71 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.59261688 |
72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.58696655 |
73 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.58448992 |
74 | Asthma_Homo sapiens_hsa05310 | 0.57205782 |
75 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.56717576 |
76 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.55294908 |
77 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.55024315 |
78 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.52276438 |
79 | Phototransduction_Homo sapiens_hsa04744 | 0.52202585 |
80 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.51294044 |
81 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.50762422 |
82 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.50158363 |
83 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.49793446 |
84 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.48300513 |
85 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.46992880 |
86 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.46522198 |
87 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.46080962 |
88 | RNA degradation_Homo sapiens_hsa03018 | 0.45810031 |
89 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.45276135 |
90 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.45220171 |
91 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.41077490 |
92 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.40944053 |
93 | Lysosome_Homo sapiens_hsa04142 | 0.40587405 |
94 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.39689659 |
95 | Galactose metabolism_Homo sapiens_hsa00052 | 0.39115349 |
96 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.38705259 |
97 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.38088954 |
98 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.38065700 |
99 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.37799650 |
100 | Retinol metabolism_Homo sapiens_hsa00830 | 0.37728472 |
101 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.37538842 |
102 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.37196749 |
103 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.37130457 |
104 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.36667252 |
105 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35788272 |
106 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.35482656 |
107 | RNA transport_Homo sapiens_hsa03013 | 0.34738014 |
108 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.34727035 |
109 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.31557052 |
110 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.31476074 |
111 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.30142338 |
112 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.29807292 |
113 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.27743481 |
114 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.27472917 |
115 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.26454612 |
116 | Legionellosis_Homo sapiens_hsa05134 | 0.26320202 |
117 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.25045180 |
118 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.23810795 |
119 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.23745172 |
120 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.22227344 |
121 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.21489281 |
122 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.20453560 |