TMEM208

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.50417072
2ATP synthesis coupled proton transport (GO:0015986)6.18871560
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.18871560
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.62377658
5ribosomal small subunit biogenesis (GO:0042274)5.37082692
6ribosomal small subunit assembly (GO:0000028)5.15522437
7respiratory electron transport chain (GO:0022904)4.98694875
8cotranslational protein targeting to membrane (GO:0006613)4.89667984
9electron transport chain (GO:0022900)4.86492100
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.85783980
11protein targeting to ER (GO:0045047)4.80379295
12viral transcription (GO:0019083)4.79576320
13chaperone-mediated protein transport (GO:0072321)4.70749873
14proteasome assembly (GO:0043248)4.70027389
15protein localization to endoplasmic reticulum (GO:0070972)4.67158438
16translational termination (GO:0006415)4.65388993
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.56926407
18protein neddylation (GO:0045116)4.43098506
19signal peptide processing (GO:0006465)4.39260101
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.36690658
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.36690658
22NADH dehydrogenase complex assembly (GO:0010257)4.36690658
23rRNA modification (GO:0000154)4.36377571
24fatty acid elongation (GO:0030497)4.25357556
25DNA deamination (GO:0045006)4.21698706
26protein complex biogenesis (GO:0070271)4.12850573
27maturation of SSU-rRNA (GO:0030490)4.09434499
28GTP biosynthetic process (GO:0006183)4.00175419
29L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.89365406
30translational elongation (GO:0006414)3.89051813
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.87297180
32termination of RNA polymerase III transcription (GO:0006386)3.87297180
33mitochondrial respiratory chain complex assembly (GO:0033108)3.76714389
34translation (GO:0006412)3.76608005
35regulation of mitochondrial translation (GO:0070129)3.75046192
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.70120890
37viral life cycle (GO:0019058)3.69638855
38ribosomal large subunit biogenesis (GO:0042273)3.68744571
39regulation of cellular amino acid metabolic process (GO:0006521)3.68344026
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67076733
41cellular protein complex disassembly (GO:0043624)3.64942987
42water-soluble vitamin biosynthetic process (GO:0042364)3.64081398
43ATP biosynthetic process (GO:0006754)3.62179914
44mannosylation (GO:0097502)3.59017301
45rRNA methylation (GO:0031167)3.58365483
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.57444039
47GPI anchor biosynthetic process (GO:0006506)3.53691160
48respiratory chain complex IV assembly (GO:0008535)3.53495245
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52986167
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51617553
51guanosine-containing compound biosynthetic process (GO:1901070)3.49871035
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.49750202
53platelet dense granule organization (GO:0060155)3.49448435
54protein targeting to mitochondrion (GO:0006626)3.47183058
55axon ensheathment in central nervous system (GO:0032291)3.46496686
56central nervous system myelination (GO:0022010)3.46496686
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.44851914
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.44306939
59GDP-mannose metabolic process (GO:0019673)3.38060436
60intracellular protein transmembrane import (GO:0044743)3.37000016
61translational initiation (GO:0006413)3.36924831
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36218677
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36218677
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.36122111
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.36122111
66pseudouridine synthesis (GO:0001522)3.34305951
67UTP biosynthetic process (GO:0006228)3.33195222
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33043962
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33043962
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33043962
71mitochondrial transport (GO:0006839)3.31696714
72establishment of protein localization to mitochondrion (GO:0072655)3.30889908
73positive regulation of ligase activity (GO:0051351)3.30088559
747-methylguanosine mRNA capping (GO:0006370)3.28334359
75L-methionine salvage (GO:0071267)3.26857554
76L-methionine biosynthetic process (GO:0071265)3.26857554
77amino acid salvage (GO:0043102)3.26857554
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26108513
79negative regulation of ligase activity (GO:0051352)3.26108513
80cholesterol biosynthetic process (GO:0006695)3.24451260
817-methylguanosine RNA capping (GO:0009452)3.22702748
82RNA capping (GO:0036260)3.22702748
83protein targeting to membrane (GO:0006612)3.21774386
84inner mitochondrial membrane organization (GO:0007007)3.21367367
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.21206906
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20748325
87hydrogen ion transmembrane transport (GO:1902600)3.19426518
88nucleotide transmembrane transport (GO:1901679)3.18906606
89signal transduction involved in DNA damage checkpoint (GO:0072422)3.17548425
90signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17548425
91protein maturation by protein folding (GO:0022417)3.17183167
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16095482
93ribonucleoside triphosphate biosynthetic process (GO:0009201)3.14626032
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14135764
95purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.13584561
96cullin deneddylation (GO:0010388)3.13571727
97signal transduction involved in cell cycle checkpoint (GO:0072395)3.13414123
98purine nucleoside triphosphate biosynthetic process (GO:0009145)3.11484100
99CTP biosynthetic process (GO:0006241)3.08371415
100CTP metabolic process (GO:0046036)3.08371415
101GPI anchor metabolic process (GO:0006505)3.07738401
102cytochrome complex assembly (GO:0017004)3.04848294
103protein localization to mitochondrion (GO:0070585)3.02221665
104establishment of integrated proviral latency (GO:0075713)3.01290058
105preassembly of GPI anchor in ER membrane (GO:0016254)3.00657929
106establishment of viral latency (GO:0019043)2.99766839
107proton transport (GO:0015992)2.99626319
108regulation of cellular amine metabolic process (GO:0033238)2.99432087
109antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.97569706
110positive regulation of cell cycle arrest (GO:0071158)2.96892335
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96237368
112protein-cofactor linkage (GO:0018065)2.95412130
113cellular component biogenesis (GO:0044085)2.95109266
114base-excision repair, AP site formation (GO:0006285)2.94918564
115regulation of ubiquitin-protein transferase activity (GO:0051438)2.94443131
116peptidyl-histidine modification (GO:0018202)2.94300781
117hydrogen transport (GO:0006818)2.93157402
118UTP metabolic process (GO:0046051)2.93098009
119protein complex disassembly (GO:0043241)2.93022231
120nucleoside triphosphate biosynthetic process (GO:0009142)2.92145958
121ATP hydrolysis coupled proton transport (GO:0015991)2.91427868
122energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91427868
123oxidative phosphorylation (GO:0006119)2.91097579
124protein deneddylation (GO:0000338)2.90222326
125aerobic respiration (GO:0009060)2.88188507
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.86965196
127L-phenylalanine metabolic process (GO:0006558)2.86965196
128DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.86641521
129pteridine-containing compound biosynthetic process (GO:0042559)2.86088465
130regulation of ligase activity (GO:0051340)2.84242931
131aldehyde catabolic process (GO:0046185)2.82140520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.85245940
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.29351626
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.79038744
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.31863334
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.21970746
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.16785415
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.54015679
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42335194
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.41619757
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.38407242
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.27371629
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12328705
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.07211308
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.05776954
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05616752
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.90918172
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.89586365
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70124567
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67761354
20* VDR_23849224_ChIP-Seq_CD4+_Human2.57355593
21DCP1A_22483619_ChIP-Seq_HELA_Human2.28511497
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16509329
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16402662
24ELK1_19687146_ChIP-ChIP_HELA_Human2.13538629
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.08164544
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01645675
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.95048888
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.94524758
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89002506
30* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87070562
31XRN2_22483619_ChIP-Seq_HELA_Human1.81831545
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79675146
33ELK1_22589737_ChIP-Seq_MCF10A_Human1.77066090
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76533959
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75684638
36IRF1_19129219_ChIP-ChIP_H3396_Human1.68229452
37GABP_19822575_ChIP-Seq_HepG2_Human1.67778419
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62413657
39* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55477475
40TTF2_22483619_ChIP-Seq_HELA_Human1.53127057
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52980504
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47853515
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44585786
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43283240
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42145008
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37417210
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35987837
48ZNF274_21170338_ChIP-Seq_K562_Hela1.35964990
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35764761
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24040130
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22059841
52KDM5A_27292631_Chip-Seq_BREAST_Human1.21450415
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.19149352
54MYC_18940864_ChIP-ChIP_HL60_Human1.18821281
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18632582
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14233708
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.11186363
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10056955
59VDR_22108803_ChIP-Seq_LS180_Human1.08874017
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08012890
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07307283
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06451226
63SOX17_20123909_ChIP-Seq_XEN_Mouse1.04904180
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04351805
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04051089
66SPI1_23547873_ChIP-Seq_NB4_Human0.99416094
67STAT1_20625510_ChIP-Seq_HELA_Human0.97372504
68HTT_18923047_ChIP-ChIP_STHdh_Human0.96663926
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96610027
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96510193
71TP53_22573176_ChIP-Seq_HFKS_Human0.96227687
72NOTCH1_21737748_ChIP-Seq_TLL_Human0.95921296
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95424130
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95418371
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94764742
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93563341
77IRF8_22096565_ChIP-ChIP_GC-B_Human0.92610729
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92519983
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92213436
80CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92155643
81* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90976289
82* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89120243
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88986893
84TAF15_26573619_Chip-Seq_HEK293_Human0.85211106
85ERG_20517297_ChIP-Seq_VCAP_Human0.84829506
86* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84442944
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83563848
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82953207
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80601639
90* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80594724
91FOXP1_21924763_ChIP-Seq_HESCs_Human0.80558153
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.80481415
93FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80481415
94STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79927624
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79820622
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79788474
97MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79126064
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77893049
99ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77794571
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76589616
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76175093
102GATA1_22025678_ChIP-Seq_K562_Human0.75722357
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75425298
104* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75047633
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74484180
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.71759528
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71652028
108NANOG_18555785_ChIP-Seq_MESCs_Mouse0.71042327
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69763344
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.69310048
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.69248253
112TFEB_21752829_ChIP-Seq_HELA_Human0.68719809
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.68614643
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68377747
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.68268486
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68181956
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.68174735
118AR_20517297_ChIP-Seq_VCAP_Human0.67356498
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.67353669
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.66802711
121EWS_26573619_Chip-Seq_HEK293_Human0.66311648
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.66283677
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66067983
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65953563
125ELF5_23300383_ChIP-Seq_T47D_Human0.63777933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.34697450
2MP0003806_abnormal_nucleotide_metabolis3.86441711
3MP0001529_abnormal_vocalization3.17559656
4MP0002254_reproductive_system_inflammat3.00661142
5MP0001905_abnormal_dopamine_level2.84593402
6MP0004147_increased_porphyrin_level2.79746306
7MP0002139_abnormal_hepatobiliary_system2.76696072
8MP0003186_abnormal_redox_activity2.75380493
9MP0000920_abnormal_myelination2.62805261
10MP0008875_abnormal_xenobiotic_pharmacok2.57128488
11MP0002837_dystrophic_cardiac_calcinosis2.56911672
12MP0001986_abnormal_taste_sensitivity2.48700428
13MP0002638_abnormal_pupillary_reflex2.39417977
14MP0003136_yellow_coat_color2.35565352
15MP0006036_abnormal_mitochondrial_physio2.06055387
16MP0004142_abnormal_muscle_tone1.98045374
17MP0000372_irregular_coat_pigmentation1.97504741
18MP0005408_hypopigmentation1.96731636
19MP0008260_abnormal_autophagy1.92685614
20MP0004019_abnormal_vitamin_homeostasis1.87668358
21MP0003656_abnormal_erythrocyte_physiolo1.86258528
22MP0003880_abnormal_central_pattern1.85079237
23MP0005171_absent_coat_pigmentation1.79184067
24MP0005379_endocrine/exocrine_gland_phen1.79123459
25MP0002132_abnormal_respiratory_system1.77238495
26MP0002148_abnormal_hypersensitivity_rea1.69567536
27MP0005174_abnormal_tail_pigmentation1.69077396
28MP0009840_abnormal_foam_cell1.68805248
29MP0006035_abnormal_mitochondrial_morpho1.64823859
30MP0003693_abnormal_embryo_hatching1.62435181
31MP0009333_abnormal_splenocyte_physiolog1.62383615
32MP0005409_darkened_coat_color1.61372940
33MP0000015_abnormal_ear_pigmentation1.57885200
34MP0001756_abnormal_urination1.55814108
35MP0005365_abnormal_bile_salt1.55412807
36MP0009785_altered_susceptibility_to1.54052708
37MP0005645_abnormal_hypothalamus_physiol1.53722029
38MP0003724_increased_susceptibility_to1.53663563
39MP0002938_white_spotting1.50411368
40MP0005075_abnormal_melanosome_morpholog1.50223645
41MP0006082_CNS_inflammation1.49342390
42MP0001542_abnormal_bone_strength1.49295890
43MP0003718_maternal_effect1.44919800
44MP0001485_abnormal_pinna_reflex1.41594443
45MP0004381_abnormal_hair_follicle1.40494847
46MP0005058_abnormal_lysosome_morphology1.39221416
47MP0010386_abnormal_urinary_bladder1.38810220
48MP0004742_abnormal_vestibular_system1.36173659
49MP0005451_abnormal_body_composition1.35295094
50MP0004133_heterotaxia1.33554303
51MP0000358_abnormal_cell_content/1.33389476
52MP0003195_calcinosis1.31826121
53MP0003011_delayed_dark_adaptation1.29181897
54MP0001835_abnormal_antigen_presentation1.28522653
55MP0003123_paternal_imprinting1.28141907
56MP0005671_abnormal_response_to1.28087890
57MP0006276_abnormal_autonomic_nervous1.26940388
58MP0009697_abnormal_copulation1.26567048
59MP0002876_abnormal_thyroid_physiology1.24839539
60MP0001764_abnormal_homeostasis1.24750632
61MP0002909_abnormal_adrenal_gland1.23535004
62MP0002163_abnormal_gland_morphology1.23314311
63MP0005636_abnormal_mineral_homeostasis1.23245567
64MP0002090_abnormal_vision1.21454818
65MP0002693_abnormal_pancreas_physiology1.20496754
66MP0005000_abnormal_immune_tolerance1.20423502
67MP0005025_abnormal_response_to1.19566692
68MP0008057_abnormal_DNA_replication1.19219491
69MP0009046_muscle_twitch1.17824961
70MP0005085_abnormal_gallbladder_physiolo1.17621625
71MP0008995_early_reproductive_senescence1.16327064
72MP0001853_heart_inflammation1.12403834
73MP0001944_abnormal_pancreas_morphology1.10567137
74MP0005646_abnormal_pituitary_gland1.10390450
75MP0002277_abnormal_respiratory_mucosa1.06511367
76MP0001188_hyperpigmentation1.06462700
77MP0001968_abnormal_touch/_nociception1.06334273
78MP0004043_abnormal_pH_regulation1.06212610
79MP0002102_abnormal_ear_morphology1.05042281
80MP0008932_abnormal_embryonic_tissue1.04845114
81MP0002736_abnormal_nociception_after1.04022079
82MP0003329_amyloid_beta_deposits1.02541913
83MP0000516_abnormal_urinary_system1.02176461
84MP0005367_renal/urinary_system_phenotyp1.02176461
85MP0008058_abnormal_DNA_repair1.02108051
86MP0004957_abnormal_blastocyst_morpholog1.01960540
87MP0002272_abnormal_nervous_system1.00730781
88MP0002419_abnormal_innate_immunity0.99566889
89MP0005084_abnormal_gallbladder_morpholo0.98567291
90MP0005319_abnormal_enzyme/_coenzyme0.97924091
91MP0001727_abnormal_embryo_implantation0.97234608
92MP0004134_abnormal_chest_morphology0.95593117
93MP0005332_abnormal_amino_acid0.95591879
94MP0001666_abnormal_nutrient_absorption0.94449352
95MP0008789_abnormal_olfactory_epithelium0.94046725
96MP0005410_abnormal_fertilization0.93651389
97MP0010329_abnormal_lipoprotein_level0.93477062
98MP0008007_abnormal_cellular_replicative0.93293983
99MP0002229_neurodegeneration0.92367494
100MP0002095_abnormal_skin_pigmentation0.91792124
101MP0005083_abnormal_biliary_tract0.89966744
102MP0006072_abnormal_retinal_apoptosis0.88831147
103MP0005551_abnormal_eye_electrophysiolog0.88710221
104MP0000538_abnormal_urinary_bladder0.88284768
105MP0002723_abnormal_immune_serum0.84191257
106MP0003690_abnormal_glial_cell0.83538896
107MP0005389_reproductive_system_phenotype0.83234527
108MP0003634_abnormal_glial_cell0.82912959
109MP0001661_extended_life_span0.82809991
110MP0002295_abnormal_pulmonary_circulatio0.82255072
111MP0003950_abnormal_plasma_membrane0.81961309
112MP0001664_abnormal_digestion0.81632377
113MP0001984_abnormal_olfaction0.80528631
114MP0001919_abnormal_reproductive_system0.80208586
115MP0008469_abnormal_protein_level0.80004939
116MP0000639_abnormal_adrenal_gland0.78136303
117MP0003121_genomic_imprinting0.77931111
118MP0006292_abnormal_olfactory_placode0.77926367
119MP0001963_abnormal_hearing_physiology0.77315749
120MP0009745_abnormal_behavioral_response0.76854402
121MP0001324_abnormal_eye_pigmentation0.76731981
122MP0008872_abnormal_physiological_respon0.75960589
123MP0005253_abnormal_eye_physiology0.74481588
124MP0005376_homeostasis/metabolism_phenot0.73916815
125MP0000681_abnormal_thyroid_gland0.71921513
126MP0009765_abnormal_xenobiotic_induced0.71588185
127MP0002210_abnormal_sex_determination0.70813491
128MP0002160_abnormal_reproductive_system0.70009291
129MP0005164_abnormal_response_to0.69787280
130MP0002734_abnormal_mechanical_nocicepti0.69403455
131MP0005360_urolithiasis0.68709961
132MP0003786_premature_aging0.68303921
133MP0003436_decreased_susceptibility_to0.67904738
134MP0008877_abnormal_DNA_methylation0.67496496
135MP0002420_abnormal_adaptive_immunity0.67392338
136MP0009643_abnormal_urine_homeostasis0.67381936
137MP0002078_abnormal_glucose_homeostasis0.67205099
138MP0001819_abnormal_immune_cell0.66180281
139MP0005584_abnormal_enzyme/coenzyme_acti0.66028187
140MP0003953_abnormal_hormone_level0.65287474
141MP0000604_amyloidosis0.64495745
142MP0003941_abnormal_skin_development0.64337152
143MP0002452_abnormal_antigen_presenting0.63418759
144MP0006054_spinal_hemorrhage0.63302753

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.76055475
2Mitochondrial inheritance (HP:0001427)5.22581682
3Abnormal mitochondria in muscle tissue (HP:0008316)5.14115454
4Acute encephalopathy (HP:0006846)4.89928985
5Progressive macrocephaly (HP:0004481)4.68877098
6Hepatocellular necrosis (HP:0001404)4.59999962
7Abnormality of cells of the erythroid lineage (HP:0012130)4.51648507
8Increased CSF lactate (HP:0002490)4.31421739
9Abnormal number of erythroid precursors (HP:0012131)4.23397442
10Hepatic necrosis (HP:0002605)4.17239164
11Increased hepatocellular lipid droplets (HP:0006565)4.15200930
12Renal Fanconi syndrome (HP:0001994)4.12155231
133-Methylglutaconic aciduria (HP:0003535)4.01493920
14Lipid accumulation in hepatocytes (HP:0006561)3.71089400
15Increased serum pyruvate (HP:0003542)3.69903401
16Abnormality of glycolysis (HP:0004366)3.69903401
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.57595752
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.53301970
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.53301970
20Parakeratosis (HP:0001036)3.44600382
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.43363112
22Reticulocytopenia (HP:0001896)3.43093261
23Type I transferrin isoform profile (HP:0003642)3.39557202
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.34205128
25Cerebral edema (HP:0002181)3.31096663
26Respiratory failure (HP:0002878)3.17688317
27Increased serum lactate (HP:0002151)3.16312236
28Leukodystrophy (HP:0002415)3.09367996
29Macrocytic anemia (HP:0001972)3.08696366
30Increased intramyocellular lipid droplets (HP:0012240)3.06860540
31Lactic acidosis (HP:0003128)3.02840428
32Exertional dyspnea (HP:0002875)2.98702647
33Optic disc pallor (HP:0000543)2.89699773
34Abnormality of the heme biosynthetic pathway (HP:0010472)2.84341604
35Exercise intolerance (HP:0003546)2.83351350
36Cerebral hypomyelination (HP:0006808)2.78854198
37Abnormality of renal resorption (HP:0011038)2.76560829
38Congenital ichthyosiform erythroderma (HP:0007431)2.73211353
39Hypothermia (HP:0002045)2.66555272
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66081492
41Abnormal protein N-linked glycosylation (HP:0012347)2.66081492
42Abnormal protein glycosylation (HP:0012346)2.66081492
43Abnormal glycosylation (HP:0012345)2.66081492
44Hypoglycemic coma (HP:0001325)2.63205458
45Pallor (HP:0000980)2.57355217
46Increased muscle lipid content (HP:0009058)2.54874247
47Hyperinsulinemic hypoglycemia (HP:0000825)2.48320618
48Respiratory difficulties (HP:0002880)2.45023706
49Aplastic anemia (HP:0001915)2.42297903
50Glycosuria (HP:0003076)2.29745917
51Abnormality of urine glucose concentration (HP:0011016)2.29745917
52Hypokinesia (HP:0002375)2.25746714
53Vacuolated lymphocytes (HP:0001922)2.22032578
54Hypoglycemic seizures (HP:0002173)2.21476760
55Reduced antithrombin III activity (HP:0001976)2.20989856
56CNS demyelination (HP:0007305)2.19154588
57Hyperglycinemia (HP:0002154)2.15904903
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15084932
59Large for gestational age (HP:0001520)2.14131058
60Microvesicular hepatic steatosis (HP:0001414)2.12435680
61Spastic paraparesis (HP:0002313)2.10780363
62Abnormality of midbrain morphology (HP:0002418)2.06988586
63Molar tooth sign on MRI (HP:0002419)2.06988586
64Aplasia/hypoplasia of the uterus (HP:0008684)2.05768313
65Degeneration of anterior horn cells (HP:0002398)2.05482575
66Abnormality of the anterior horn cell (HP:0006802)2.05482575
67Congenital, generalized hypertrichosis (HP:0004540)2.04870533
68Generalized aminoaciduria (HP:0002909)2.03179720
69Abnormality of methionine metabolism (HP:0010901)2.03120966
70Hepatosplenomegaly (HP:0001433)2.01653560
71Ketoacidosis (HP:0001993)2.01164800
72Oral leukoplakia (HP:0002745)2.00356822
73Prolonged neonatal jaundice (HP:0006579)1.99712583
74Irregular epiphyses (HP:0010582)1.98156830
75Lethargy (HP:0001254)1.98018349
76Sensory axonal neuropathy (HP:0003390)1.97410099
77Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97223180
78Pancreatic fibrosis (HP:0100732)1.96240617
79Abnormality of placental membranes (HP:0011409)1.96033506
80Amniotic constriction ring (HP:0009775)1.96033506
81Patchy hypopigmentation of hair (HP:0011365)1.93708868
82Hyperphosphaturia (HP:0003109)1.90684688
83Pancreatic cysts (HP:0001737)1.90662451
84Hypoplasia of the uterus (HP:0000013)1.89269979
85Abnormal pupillary function (HP:0007686)1.85938631
86Methylmalonic aciduria (HP:0012120)1.83369286
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83203929
88Abnormality of alanine metabolism (HP:0010916)1.83203929
89Hyperalaninemia (HP:0003348)1.83203929
90Poor suck (HP:0002033)1.83044531
91Nausea (HP:0002018)1.82533074
92Testicular atrophy (HP:0000029)1.82527173
93Abnormal hemoglobin (HP:0011902)1.81871870
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81308990
95X-linked dominant inheritance (HP:0001423)1.81101567
96Methylmalonic acidemia (HP:0002912)1.80826306
97Abnormality of vitamin B metabolism (HP:0004340)1.79681813
98Abnormality of serum amino acid levels (HP:0003112)1.79250729
99Sparse eyelashes (HP:0000653)1.79211946
100True hermaphroditism (HP:0010459)1.79169455
101Poor head control (HP:0002421)1.78786707
102CNS hypomyelination (HP:0003429)1.78752636
103Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78551389
104Medial flaring of the eyebrow (HP:0010747)1.78428743
105Rough bone trabeculation (HP:0100670)1.76694729
106Ketosis (HP:0001946)1.76626009
107Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75168769
108Symptomatic seizures (HP:0011145)1.74233071
109Pancytopenia (HP:0001876)1.74173607
110Stenosis of the external auditory canal (HP:0000402)1.73281204
111Delayed CNS myelination (HP:0002188)1.72812407
112Retinal dysplasia (HP:0007973)1.71953955
113Gliosis (HP:0002171)1.70895220
114Autoamputation (HP:0001218)1.70014364
115Emotional lability (HP:0000712)1.69045783
116Renal tubular dysfunction (HP:0000124)1.68899646
117Hyperglycemia (HP:0003074)1.68698689
118Purpura (HP:0000979)1.67743948
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.66116742
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66116742
121Brushfield spots (HP:0001088)1.61896889
122Opisthotonus (HP:0002179)1.58461164
123White forelock (HP:0002211)1.58301539
124Abnormality of macrophages (HP:0004311)1.57849220
125Blindness (HP:0000618)1.57222146
126Neuroendocrine neoplasm (HP:0100634)1.56709871
127Steatorrhea (HP:0002570)1.53845763
128Dicarboxylic aciduria (HP:0003215)1.52880171
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.52880171
130Abnormal urine phosphate concentration (HP:0012599)1.52448651
131Abnormality of secondary sexual hair (HP:0009888)1.51525274
132Abnormality of the axillary hair (HP:0100134)1.51525274
133Type 2 muscle fiber atrophy (HP:0003554)1.50601556
134Vomiting (HP:0002013)1.49985608
135Petechiae (HP:0000967)1.49692711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.48553281
2NME23.91725443
3STK163.86084553
4PBK3.32171359
5STK392.76719129
6TNIK2.65569600
7PDK22.56068563
8MST42.42386514
9CDK192.36019473
10EIF2AK32.31111779
11NME12.22634539
12VRK12.19749984
13PIM22.18504005
14BUB12.10857041
15OXSR12.08825935
16EIF2AK12.08743580
17MUSK1.97807236
18TRIM281.93314032
19WNK31.85030516
20MAP3K121.79432592
21ARAF1.72764041
22MAP4K21.72117900
23MAPKAPK51.71901640
24BMPR1B1.71214310
25FRK1.66796463
26IRAK31.56382231
27WEE11.55619165
28BCR1.52819383
29BCKDK1.49916444
30NUAK11.45239983
31NEK11.44813482
32SRPK11.44038324
33CASK1.42301163
34WNK41.38838970
35TLK11.36607057
36ABL21.29494557
37IRAK41.27142372
38LIMK11.25326319
39PLK31.24935638
40CSNK1G31.24075811
41GRK71.12734337
42TESK21.10858899
43DYRK21.08721197
44DAPK11.05296597
45ILK1.02777378
46ADRBK21.01961019
47MYLK0.98341930
48BRAF0.97370207
49TAF10.97263123
50PAK40.96632379
51MKNK10.95261573
52INSRR0.89303435
53CCNB10.89283608
54PRKCI0.88803629
55KIT0.86122117
56TXK0.83933919
57CSNK1G10.83515838
58IRAK20.82804443
59BRSK20.82787707
60PHKG20.80782220
61PHKG10.80782220
62CAMK2B0.80341141
63NEK60.80286410
64PLK10.80258536
65BLK0.80000859
66TSSK60.79291569
67DAPK30.79278493
68MAP2K70.79237324
69BRSK10.78025810
70RPS6KA50.77251744
71AURKA0.75939219
72PAK30.75242980
73PIK3CG0.73140747
74EIF2AK20.72747236
75KDR0.71756526
76TEC0.70010709
77PRKCG0.68099286
78MAP3K110.67902321
79MKNK20.67799329
80CLK10.66977267
81LRRK20.66853456
82BMPR20.66262643
83ACVR1B0.64965936
84IKBKB0.64792994
85TTK0.62275388
86CSNK1A1L0.62137511
87MAP3K140.61190153
88UHMK10.60933445
89PLK40.59916789
90MAPK150.58054139
91GRK10.58030600
92CAMK2D0.57846640
93LYN0.57706871
94CSNK2A10.57598693
95ZAK0.57303290
96CSNK1G20.57140070
97IRAK10.56585880
98CAMK2G0.56355020
99MAPK130.55807662
100YES10.55540681
101PKN10.55530505
102MAP4K10.54612929
103PLK20.54355547
104SYK0.51448693
105MAP3K30.51361533
106CAMKK20.50461453
107CSNK2A20.50182757
108DYRK30.49510451
109STK40.48820660
110MET0.48192762
111TBK10.46741722
112PINK10.45759641
113TAOK20.45549125
114FGFR20.44573646
115AURKB0.43699066
116ERBB30.42206578
117PRKCE0.41813365
118CDK30.41375671
119CDC70.40469421
120MAPKAPK30.40141859
121TESK10.39975349
122MAPK40.39138834
123MST1R0.38090987
124SIK30.37698912
125CSNK1A10.37460330
126CHEK20.36996573
127BTK0.36975536
128GRK50.36733821
129PAK10.35569498
130PRPF4B0.34837821
131OBSCN0.34533832
132PRKCQ0.33754752
133ADRBK10.33223349
134EPHB10.32149581
135TRPM70.31670282
136FER0.30054160
137MAP2K60.28901517
138PRKG20.27861501
139CDK80.27845821
140PRKACA0.27822221

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.59474918
2Ribosome_Homo sapiens_hsa030104.42710786
3Protein export_Homo sapiens_hsa030604.09747190
4Proteasome_Homo sapiens_hsa030504.06813467
5Parkinsons disease_Homo sapiens_hsa050123.74182058
6RNA polymerase_Homo sapiens_hsa030203.00300380
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.72335286
8Alzheimers disease_Homo sapiens_hsa050102.71670846
9Huntingtons disease_Homo sapiens_hsa050162.58547795
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41012448
11Fatty acid elongation_Homo sapiens_hsa000622.27985586
12Steroid biosynthesis_Homo sapiens_hsa001002.16026352
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94148886
14Pyrimidine metabolism_Homo sapiens_hsa002401.82298528
15Folate biosynthesis_Homo sapiens_hsa007901.71784002
16Sulfur metabolism_Homo sapiens_hsa009201.67304482
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62033437
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61155652
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58981185
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55012956
21Collecting duct acid secretion_Homo sapiens_hsa049661.42434456
22DNA replication_Homo sapiens_hsa030301.39024494
23Sphingolipid metabolism_Homo sapiens_hsa006001.28278876
24Mismatch repair_Homo sapiens_hsa034301.24133210
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23623206
26Homologous recombination_Homo sapiens_hsa034401.21599469
27Nucleotide excision repair_Homo sapiens_hsa034201.19479704
28Spliceosome_Homo sapiens_hsa030401.16430709
29Glutathione metabolism_Homo sapiens_hsa004801.16415914
30Vibrio cholerae infection_Homo sapiens_hsa051101.16037227
31Ether lipid metabolism_Homo sapiens_hsa005651.15878243
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15529973
33Basal transcription factors_Homo sapiens_hsa030221.07793034
34One carbon pool by folate_Homo sapiens_hsa006701.05570616
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01655488
36Purine metabolism_Homo sapiens_hsa002301.00721252
37Metabolic pathways_Homo sapiens_hsa011000.98276370
38Histidine metabolism_Homo sapiens_hsa003400.97057319
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96179465
40Rheumatoid arthritis_Homo sapiens_hsa053230.95473138
41Cardiac muscle contraction_Homo sapiens_hsa042600.93573472
42Sulfur relay system_Homo sapiens_hsa041220.92610815
43Arachidonic acid metabolism_Homo sapiens_hsa005900.91039093
44Peroxisome_Homo sapiens_hsa041460.89158830
45Linoleic acid metabolism_Homo sapiens_hsa005910.85940817
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85450263
47Base excision repair_Homo sapiens_hsa034100.84607880
48Selenocompound metabolism_Homo sapiens_hsa004500.84075819
49Tryptophan metabolism_Homo sapiens_hsa003800.83736023
50Other glycan degradation_Homo sapiens_hsa005110.83513514
51Non-homologous end-joining_Homo sapiens_hsa034500.81731782
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.80941137
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80835602
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79975390
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76775568
56Arginine and proline metabolism_Homo sapiens_hsa003300.75620705
57Regulation of autophagy_Homo sapiens_hsa041400.71968240
58N-Glycan biosynthesis_Homo sapiens_hsa005100.71251015
59Carbon metabolism_Homo sapiens_hsa012000.67437206
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66625330
61Fatty acid degradation_Homo sapiens_hsa000710.66451882
62Caffeine metabolism_Homo sapiens_hsa002320.65495379
63Allograft rejection_Homo sapiens_hsa053300.65136780
64Mineral absorption_Homo sapiens_hsa049780.64265604
65Phagosome_Homo sapiens_hsa041450.63910711
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.63044715
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62163985
68Vitamin B6 metabolism_Homo sapiens_hsa007500.61385678
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59370989
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59323629
71Fanconi anemia pathway_Homo sapiens_hsa034600.59261688
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58696655
73Tyrosine metabolism_Homo sapiens_hsa003500.58448992
74Asthma_Homo sapiens_hsa053100.57205782
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56717576
76Fatty acid metabolism_Homo sapiens_hsa012120.55294908
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.55024315
78Pyruvate metabolism_Homo sapiens_hsa006200.52276438
79Phototransduction_Homo sapiens_hsa047440.52202585
80Chemical carcinogenesis_Homo sapiens_hsa052040.51294044
81Graft-versus-host disease_Homo sapiens_hsa053320.50762422
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50158363
83Autoimmune thyroid disease_Homo sapiens_hsa053200.49793446
84Pentose phosphate pathway_Homo sapiens_hsa000300.48300513
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46992880
86Nitrogen metabolism_Homo sapiens_hsa009100.46522198
87Propanoate metabolism_Homo sapiens_hsa006400.46080962
88RNA degradation_Homo sapiens_hsa030180.45810031
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45276135
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45220171
91Synaptic vesicle cycle_Homo sapiens_hsa047210.41077490
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40944053
93Lysosome_Homo sapiens_hsa041420.40587405
94Phenylalanine metabolism_Homo sapiens_hsa003600.39689659
95Galactose metabolism_Homo sapiens_hsa000520.39115349
96Biosynthesis of amino acids_Homo sapiens_hsa012300.38705259
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.38088954
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38065700
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37799650
100Retinol metabolism_Homo sapiens_hsa008300.37728472
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.37538842
102Butanoate metabolism_Homo sapiens_hsa006500.37196749
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37130457
104Fat digestion and absorption_Homo sapiens_hsa049750.36667252
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35788272
106Type I diabetes mellitus_Homo sapiens_hsa049400.35482656
107RNA transport_Homo sapiens_hsa030130.34738014
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.34727035
109Epstein-Barr virus infection_Homo sapiens_hsa051690.31557052
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31476074
111Hematopoietic cell lineage_Homo sapiens_hsa046400.30142338
112beta-Alanine metabolism_Homo sapiens_hsa004100.29807292
113Vitamin digestion and absorption_Homo sapiens_hsa049770.27743481
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27472917
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26454612
116Legionellosis_Homo sapiens_hsa051340.26320202
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.25045180
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23810795
119Fructose and mannose metabolism_Homo sapiens_hsa000510.23745172
120Systemic lupus erythematosus_Homo sapiens_hsa053220.22227344
121Primary immunodeficiency_Homo sapiens_hsa053400.21489281
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20453560

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