TMEM209

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.30441256
2DNA replication initiation (GO:0006270)4.22980453
3telomere maintenance via semi-conservative replication (GO:0032201)4.20128060
4DNA strand elongation (GO:0022616)4.13201969
5replication fork processing (GO:0031297)4.12771333
6CENP-A containing nucleosome assembly (GO:0034080)4.04273026
7DNA replication checkpoint (GO:0000076)4.03989525
8mitotic metaphase plate congression (GO:0007080)4.01477874
9chromatin remodeling at centromere (GO:0031055)3.99128920
10kinetochore organization (GO:0051383)3.98682889
11synapsis (GO:0007129)3.93984601
12telomere maintenance via recombination (GO:0000722)3.93954590
13regulation of nuclear cell cycle DNA replication (GO:0033262)3.86089896
14mitotic recombination (GO:0006312)3.83300096
15protein localization to kinetochore (GO:0034501)3.79276953
16kinetochore assembly (GO:0051382)3.69329967
17nuclear pore organization (GO:0006999)3.68932851
18proteasome assembly (GO:0043248)3.68443461
19metaphase plate congression (GO:0051310)3.63430991
20telomere maintenance via telomere lengthening (GO:0010833)3.61418567
21DNA unwinding involved in DNA replication (GO:0006268)3.61337587
22DNA replication-independent nucleosome assembly (GO:0006336)3.58847837
23DNA replication-independent nucleosome organization (GO:0034724)3.58847837
24nucleobase biosynthetic process (GO:0046112)3.52309861
25IMP biosynthetic process (GO:0006188)3.50468738
26negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.47036597
27negative regulation of sister chromatid segregation (GO:0033046)3.47036597
28negative regulation of mitotic sister chromatid separation (GO:2000816)3.47036597
29negative regulation of mitotic sister chromatid segregation (GO:0033048)3.47036597
30establishment of chromosome localization (GO:0051303)3.46017573
31DNA replication-dependent nucleosome assembly (GO:0006335)3.44602411
32DNA replication-dependent nucleosome organization (GO:0034723)3.44602411
33negative regulation of chromosome segregation (GO:0051985)3.44212567
34mitotic nuclear envelope disassembly (GO:0007077)3.43470228
35nuclear pore complex assembly (GO:0051292)3.42887240
36negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.42755127
37regulation of spindle organization (GO:0090224)3.42408935
38resolution of meiotic recombination intermediates (GO:0000712)3.41475616
39spindle checkpoint (GO:0031577)3.40464794
40spindle assembly checkpoint (GO:0071173)3.38832291
41protein localization to chromosome, centromeric region (GO:0071459)3.37385115
42ribosomal small subunit assembly (GO:0000028)3.36211714
43mitotic sister chromatid segregation (GO:0000070)3.35946054
44DNA catabolic process, exonucleolytic (GO:0000738)3.35542429
45mitotic spindle assembly checkpoint (GO:0007094)3.35066775
46attachment of spindle microtubules to kinetochore (GO:0008608)3.35002435
47histone exchange (GO:0043486)3.33342806
48protein K6-linked ubiquitination (GO:0085020)3.32820128
49regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32268303
50regulation of DNA endoreduplication (GO:0032875)3.29608233
51mitotic spindle checkpoint (GO:0071174)3.29600402
52recombinational repair (GO:0000725)3.29395433
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.29295537
54regulation of double-strand break repair via homologous recombination (GO:0010569)3.29227428
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.29012835
56double-strand break repair via homologous recombination (GO:0000724)3.28704142
57regulation of helicase activity (GO:0051095)3.28656494
58purine nucleobase biosynthetic process (GO:0009113)3.28593535
59respiratory chain complex IV assembly (GO:0008535)3.28427386
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.27587418
61regulation of mitotic spindle checkpoint (GO:1903504)3.27587418
62water-soluble vitamin biosynthetic process (GO:0042364)3.26758787
63cullin deneddylation (GO:0010388)3.26341053
64ribosome biogenesis (GO:0042254)3.24809332
65somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.24396168
66isotype switching (GO:0045190)3.24396168
67somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.24396168
68meiotic chromosome segregation (GO:0045132)3.22007929
69ribosome assembly (GO:0042255)3.19875432
70somatic hypermutation of immunoglobulin genes (GO:0016446)3.18864305
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18864305
72DNA ligation (GO:0006266)3.18430115
73platelet dense granule organization (GO:0060155)3.17508972
74regulation of mitotic sister chromatid separation (GO:0010965)3.17215615
75regulation of mitotic sister chromatid segregation (GO:0033047)3.17215615
76regulation of sister chromatid segregation (GO:0033045)3.17215615
77double-strand break repair via nonhomologous end joining (GO:0006303)3.15206232
78non-recombinational repair (GO:0000726)3.15206232
79DNA deamination (GO:0045006)3.13455461
80lactate metabolic process (GO:0006089)3.10572729
81regulation of chromosome segregation (GO:0051983)3.10562374
82mismatch repair (GO:0006298)3.10422354
83membrane disassembly (GO:0030397)3.10093297
84nuclear envelope disassembly (GO:0051081)3.10093297
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09596586
86maturation of SSU-rRNA (GO:0030490)3.08749022
87regulation of mitotic spindle organization (GO:0060236)3.08436706
88peptidyl-histidine modification (GO:0018202)3.08275363
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07227787
90telomere maintenance (GO:0000723)3.07184835
91telomere organization (GO:0032200)3.06029465
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05217044
93DNA double-strand break processing (GO:0000729)3.02396664
94sister chromatid segregation (GO:0000819)3.02296321
95negative regulation of DNA-dependent DNA replication (GO:2000104)3.01902983
96protein deneddylation (GO:0000338)3.00513637
97regulation of centriole replication (GO:0046599)2.99749353
98response to pheromone (GO:0019236)2.99184398
99ribosomal large subunit biogenesis (GO:0042273)2.98130662
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98091380
101histone H2A acetylation (GO:0043968)2.96571422
102ribonucleoprotein complex biogenesis (GO:0022613)2.96334839
103mitotic chromosome condensation (GO:0007076)2.95871746
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95742814
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94892933
106regulation of centrosome cycle (GO:0046605)2.94321096
107intra-S DNA damage checkpoint (GO:0031573)2.91656102
108pore complex assembly (GO:0046931)2.91486935
109negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90847021
110IMP metabolic process (GO:0046040)2.90794329
111spliceosomal snRNP assembly (GO:0000387)2.89836395
112regulation of telomere maintenance via telomerase (GO:0032210)2.88844534
113transcription-coupled nucleotide-excision repair (GO:0006283)2.87827567
114maturation of 5.8S rRNA (GO:0000460)2.87250381
115viral mRNA export from host cell nucleus (GO:0046784)2.85802319
116postreplication repair (GO:0006301)2.84995003
117negative regulation of mitosis (GO:0045839)2.84376473
118DNA geometric change (GO:0032392)2.84213070
119negative regulation of DNA recombination (GO:0045910)2.84208507
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83882445
121formation of translation preinitiation complex (GO:0001731)2.83229157
122DNA duplex unwinding (GO:0032508)2.82994816
123centriole replication (GO:0007099)2.82883526
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82325930
125folic acid-containing compound biosynthetic process (GO:0009396)2.81900072
126rRNA methylation (GO:0031167)2.81775873
127DNA replication (GO:0006260)2.79655819
128rRNA modification (GO:0000154)2.79329062
129chromosome segregation (GO:0007059)2.78851089
130reciprocal meiotic recombination (GO:0007131)2.78776383
131reciprocal DNA recombination (GO:0035825)2.78776383
132termination of RNA polymerase III transcription (GO:0006386)2.78502826
133transcription elongation from RNA polymerase III promoter (GO:0006385)2.78502826
134rRNA processing (GO:0006364)2.77776740
135cytochrome complex assembly (GO:0017004)2.77426806
136DNA-dependent DNA replication (GO:0006261)2.77235504
137establishment of integrated proviral latency (GO:0075713)2.75616516
138ATP-dependent chromatin remodeling (GO:0043044)2.75107959
139mitotic sister chromatid cohesion (GO:0007064)2.74798516
140anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73901039
141signal peptide processing (GO:0006465)2.71416910
142double-strand break repair (GO:0006302)2.70197376
143DNA strand renaturation (GO:0000733)2.69402949
144somatic recombination of immunoglobulin gene segments (GO:0016447)2.68917283
145pseudouridine synthesis (GO:0001522)2.67117365
146amino acid activation (GO:0043038)2.66441399
147tRNA aminoacylation (GO:0043039)2.66441399
148microtubule depolymerization (GO:0007019)2.64670203
149telomere maintenance via telomerase (GO:0007004)2.63885617
150somatic diversification of immunoglobulins (GO:0016445)2.63396268
151tRNA aminoacylation for protein translation (GO:0006418)2.62905081
152prenylation (GO:0097354)2.62360643
153protein prenylation (GO:0018342)2.62360643
154signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61007641
155signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61007641
156signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61007641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.72395778
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.42150542
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.29566032
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.05469318
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.48949393
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17643653
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88893112
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.81802167
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81684105
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75021521
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.69120796
12ZNF274_21170338_ChIP-Seq_K562_Hela2.69003736
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60958868
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56252260
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55583360
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.48722939
17VDR_22108803_ChIP-Seq_LS180_Human2.34118010
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33195000
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.30844911
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26221054
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26121659
22VDR_23849224_ChIP-Seq_CD4+_Human2.25090440
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23018642
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22268858
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20705140
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18655270
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15178658
28XRN2_22483619_ChIP-Seq_HELA_Human2.12661482
29FUS_26573619_Chip-Seq_HEK293_Human2.12579711
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.09362037
31FOXP3_21729870_ChIP-Seq_TREG_Human2.03052110
32AR_21909140_ChIP-Seq_LNCAP_Human2.00246070
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97378252
34ELK1_19687146_ChIP-ChIP_HELA_Human1.95224464
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93531169
36IGF1R_20145208_ChIP-Seq_DFB_Human1.92468277
37* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86913302
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86129148
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85145455
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.83446863
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82006264
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81829814
43DCP1A_22483619_ChIP-Seq_HELA_Human1.81401613
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.80060810
45* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78704121
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76132206
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75719375
48* TTF2_22483619_ChIP-Seq_HELA_Human1.74437614
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73270279
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69974622
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69343496
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.68740685
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65082872
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62819214
55GABP_19822575_ChIP-Seq_HepG2_Human1.62642688
56P300_19829295_ChIP-Seq_ESCs_Human1.58701202
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55667033
58CIITA_25753668_ChIP-Seq_RAJI_Human1.55422960
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.55346379
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54443739
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53136247
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51292063
63TAF15_26573619_Chip-Seq_HEK293_Human1.48810912
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.45526854
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42525596
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41799003
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39098041
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37524505
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37503562
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35245597
71GBX2_23144817_ChIP-Seq_PC3_Human1.35040042
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33649553
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.33575999
74ER_23166858_ChIP-Seq_MCF-7_Human1.33241027
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.32715728
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31829712
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30690544
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30475164
79KDM5A_27292631_Chip-Seq_BREAST_Human1.30093322
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29904849
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27349549
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26928856
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24374331
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22830539
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20586289
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20529824
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19829387
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17756751
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16963813
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16858218
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16858218
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16858218
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16366948
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.14659021
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13420189
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13107440
97TP53_22573176_ChIP-Seq_HFKS_Human1.12133143
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09896975
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08839427
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08107395
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07373131
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06538699
103NANOG_19829295_ChIP-Seq_ESCs_Human1.06140272
104SOX2_19829295_ChIP-Seq_ESCs_Human1.06140272
105CBP_20019798_ChIP-Seq_JUKART_Human1.04801877
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04801877
107MYC_18940864_ChIP-ChIP_HL60_Human1.04402143
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04300807
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04241109
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02352891
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.01737504
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01663731
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00129480
114TFEB_21752829_ChIP-Seq_HELA_Human0.98362552
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97461426
116BCAT_22108803_ChIP-Seq_LS180_Human0.96931818
117MYC_22102868_ChIP-Seq_BL_Human0.96171670
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95165181
119KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94830972
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94472053
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94308661
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93383637
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92554306
124STAT3_23295773_ChIP-Seq_U87_Human0.91464009
125TCF4_22108803_ChIP-Seq_LS180_Human0.90919313
126FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90284639
127FOXA1_25329375_ChIP-Seq_VCAP_Human0.90284639
128PHF8_20622853_ChIP-Seq_HELA_Human0.89770028
129SPI1_23547873_ChIP-Seq_NB4_Human0.89411446
130* SMAD4_21799915_ChIP-Seq_A2780_Human0.89269514
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89213535
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.88583706
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87864211
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87616384
135CDX2_22108803_ChIP-Seq_LS180_Human0.87551220
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83405442
137PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82226861
138TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80153527
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79812026
140NANOG_16153702_ChIP-ChIP_HESCs_Human0.78911427
141NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77326951
142NANOG_21062744_ChIP-ChIP_HESCs_Human0.76353656
143IRF1_19129219_ChIP-ChIP_H3396_Human0.76217201
144ELK1_22589737_ChIP-Seq_MCF10A_Human0.73997267
145IRF8_21731497_ChIP-ChIP_J774_Mouse0.71398690
146TCF3_18692474_ChIP-Seq_MESCs_Mouse0.70825914
147EWS_26573619_Chip-Seq_HEK293_Human0.68712847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.75867315
2MP0010094_abnormal_chromosome_stability4.58530241
3MP0003111_abnormal_nucleus_morphology4.30732101
4MP0008057_abnormal_DNA_replication4.26282877
5MP0003077_abnormal_cell_cycle3.77796982
6MP0008058_abnormal_DNA_repair3.62500539
7MP0004957_abnormal_blastocyst_morpholog3.47008492
8MP0008007_abnormal_cellular_replicative3.34349089
9MP0008932_abnormal_embryonic_tissue2.46336510
10MP0002396_abnormal_hematopoietic_system2.37663792
11MP0006072_abnormal_retinal_apoptosis2.29723962
12MP0003195_calcinosis2.27114239
13MP0003136_yellow_coat_color2.19678684
14MP0003786_premature_aging2.16380734
15MP0009697_abnormal_copulation2.16073265
16MP0008877_abnormal_DNA_methylation2.15798962
17MP0008995_early_reproductive_senescence2.01933757
18MP0003941_abnormal_skin_development1.95937817
19MP0006292_abnormal_olfactory_placode1.94368158
20MP0000350_abnormal_cell_proliferation1.83723555
21MP0000490_abnormal_crypts_of1.74166232
22MP0002163_abnormal_gland_morphology1.72084699
23MP0001984_abnormal_olfaction1.58691964
24MP0001529_abnormal_vocalization1.58173183
25MP0005379_endocrine/exocrine_gland_phen1.58172641
26MP0004808_abnormal_hematopoietic_stem1.58083953
27MP0005253_abnormal_eye_physiology1.57628669
28MP0002837_dystrophic_cardiac_calcinosis1.55915133
29MP0003718_maternal_effect1.55137692
30MP0001730_embryonic_growth_arrest1.52926395
31MP0010352_gastrointestinal_tract_polyps1.51447361
32MP0003123_paternal_imprinting1.50801556
33MP0000427_abnormal_hair_cycle1.50416564
34MP0000647_abnormal_sebaceous_gland1.50130946
35MP0003763_abnormal_thymus_physiology1.50028712
36MP0010307_abnormal_tumor_latency1.46491674
37MP0005174_abnormal_tail_pigmentation1.45608699
38MP0002210_abnormal_sex_determination1.45491860
39MP0000015_abnormal_ear_pigmentation1.44525721
40MP0004147_increased_porphyrin_level1.43715452
41MP0005551_abnormal_eye_electrophysiolog1.42702134
42MP0006035_abnormal_mitochondrial_morpho1.41955592
43MP0006036_abnormal_mitochondrial_physio1.39991454
44MP0002095_abnormal_skin_pigmentation1.31832093
45MP0003121_genomic_imprinting1.30863864
46MP0002132_abnormal_respiratory_system1.29834240
47MP0005380_embryogenesis_phenotype1.28589081
48MP0001672_abnormal_embryogenesis/_devel1.28589081
49MP0000313_abnormal_cell_death1.26748455
50MP0001293_anophthalmia1.24396481
51MP0000516_abnormal_urinary_system1.24275919
52MP0005367_renal/urinary_system_phenotyp1.24275919
53MP0002085_abnormal_embryonic_tissue1.23865063
54MP0001697_abnormal_embryo_size1.23339874
55MP0000631_abnormal_neuroendocrine_gland1.22847855
56MP0002102_abnormal_ear_morphology1.22642702
57MP0008789_abnormal_olfactory_epithelium1.21610242
58MP0005171_absent_coat_pigmentation1.20679484
59MP0001188_hyperpigmentation1.19550750
60MP0003890_abnormal_embryonic-extraembry1.19417093
61MP0005645_abnormal_hypothalamus_physiol1.18766617
62MP0005075_abnormal_melanosome_morpholog1.18458522
63MP0002019_abnormal_tumor_incidence1.17411266
64MP0001145_abnormal_male_reproductive1.14802717
65MP0001119_abnormal_female_reproductive1.13829384
66MP0002751_abnormal_autonomic_nervous1.13734125
67MP0002254_reproductive_system_inflammat1.12814376
68MP0008872_abnormal_physiological_respon1.12470894
69MP0001929_abnormal_gametogenesis1.12433621
70MP0000703_abnormal_thymus_morphology1.09147854
71MP0002234_abnormal_pharynx_morphology1.08799460
72MP0009333_abnormal_splenocyte_physiolog1.08646998
73MP0002084_abnormal_developmental_patter1.07842542
74MP0002080_prenatal_lethality1.07788646
75MP0003315_abnormal_perineum_morphology1.04739764
76MP0003186_abnormal_redox_activity1.04391941
77MP0003984_embryonic_growth_retardation1.04123815
78MP0002398_abnormal_bone_marrow1.04069821
79MP0001986_abnormal_taste_sensitivity1.03862097
80MP0003698_abnormal_male_reproductive1.03722939
81MP0000653_abnormal_sex_gland1.03057759
82MP0008260_abnormal_autophagy1.01386480
83MP0002090_abnormal_vision1.01307914
84MP0001764_abnormal_homeostasis1.01230377
85MP0002088_abnormal_embryonic_growth/wei1.01225080
86MP0003806_abnormal_nucleotide_metabolis1.00567951
87MP0002938_white_spotting0.99467698
88MP0004197_abnormal_fetal_growth/weight/0.98455025
89MP0002233_abnormal_nose_morphology0.96763674
90MP0003787_abnormal_imprinting0.96535559
91MP0003937_abnormal_limbs/digits/tail_de0.96401406
92MP0002638_abnormal_pupillary_reflex0.96008781
93MP0002086_abnormal_extraembryonic_tissu0.94929177
94MP0005646_abnormal_pituitary_gland0.94909260
95MP0002075_abnormal_coat/hair_pigmentati0.93556789
96MP0000049_abnormal_middle_ear0.93372701
97MP0010678_abnormal_skin_adnexa0.93326034
98MP0002722_abnormal_immune_system0.93137692
99MP0005084_abnormal_gallbladder_morpholo0.92998499
100MP0008875_abnormal_xenobiotic_pharmacok0.92524436
101MP0004133_heterotaxia0.92162565
102MP0000372_irregular_coat_pigmentation0.91551759
103MP0000689_abnormal_spleen_morphology0.91145741
104MP0003943_abnormal_hepatobiliary_system0.90868676
105MP0003567_abnormal_fetal_cardiomyocyte0.90793877
106MP0000383_abnormal_hair_follicle0.90684377
107MP0002277_abnormal_respiratory_mucosa0.90652502
108MP0001485_abnormal_pinna_reflex0.90403494
109MP0005397_hematopoietic_system_phenotyp0.89807577
110MP0001545_abnormal_hematopoietic_system0.89807577
111MP0005410_abnormal_fertilization0.89009957
112MP0005409_darkened_coat_color0.87737400
113MP0000358_abnormal_cell_content/0.87453369
114MP0005220_abnormal_exocrine_pancreas0.87051353
115MP0004215_abnormal_myocardial_fiber0.86940567
116MP0005499_abnormal_olfactory_system0.86785474
117MP0005394_taste/olfaction_phenotype0.86785474
118MP0005389_reproductive_system_phenotype0.86642898
119MP0005671_abnormal_response_to0.86525062
120MP0002736_abnormal_nociception_after0.86441950
121MP0001919_abnormal_reproductive_system0.86179971
122MP0001186_pigmentation_phenotype0.86154867
123MP0001835_abnormal_antigen_presentation0.85802321
124MP0005391_vision/eye_phenotype0.84467231
125MP0010030_abnormal_orbit_morphology0.84194511
126MP0002111_abnormal_tail_morphology0.83134490
127MP0002928_abnormal_bile_duct0.83134154
128MP0002160_abnormal_reproductive_system0.83127092
129MP0009046_muscle_twitch0.81724306
130MP0002876_abnormal_thyroid_physiology0.81377169
131MP0003122_maternal_imprinting0.80673870
132MP0009379_abnormal_foot_pigmentation0.80544413
133MP0005395_other_phenotype0.80143560
134MP0000858_altered_metastatic_potential0.78902618
135MP0001286_abnormal_eye_development0.78723017
136MP0001915_intracranial_hemorrhage0.78660425
137MP0005408_hypopigmentation0.77533198
138MP0002282_abnormal_trachea_morphology0.76102268
139MP0005187_abnormal_penis_morphology0.75849034
140MP0005636_abnormal_mineral_homeostasis0.75789899
141MP0005332_abnormal_amino_acid0.75466982
142MP0001873_stomach_inflammation0.75417112
143MP0000569_abnormal_digit_pigmentation0.75328966
144MP0002429_abnormal_blood_cell0.74968383
145MP0001324_abnormal_eye_pigmentation0.73821001
146MP0002653_abnormal_ependyma_morphology0.73505090
147MP0000613_abnormal_salivary_gland0.73231255
148MP0000716_abnormal_immune_system0.72368906
149MP0000566_synostosis0.71486808
150MP0005621_abnormal_cell_physiology0.71132765
151MP0005384_cellular_phenotype0.70377094
152MP0000432_abnormal_head_morphology0.68938624
153MP0006054_spinal_hemorrhage0.67771432
154MP0003119_abnormal_digestive_system0.67392595
155MP0001800_abnormal_humoral_immune0.67351743
156MP0001853_heart_inflammation0.66944190
157MP0003755_abnormal_palate_morphology0.64628766
158MP0002420_abnormal_adaptive_immunity0.64020041
159MP0005076_abnormal_cell_differentiation0.63740065

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.34993872
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.29072024
3Birth length less than 3rd percentile (HP:0003561)4.55650185
4Abnormality of chromosome stability (HP:0003220)3.70975923
5Meckel diverticulum (HP:0002245)3.70215011
6Abnormality of the preputium (HP:0100587)3.64517119
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.63769668
8Reticulocytopenia (HP:0001896)3.58329828
9Abnormality of the ileum (HP:0001549)3.50215219
10Breast hypoplasia (HP:0003187)3.47100244
11Selective tooth agenesis (HP:0001592)3.29728120
12Abnormality of the renal collecting system (HP:0004742)3.28371736
13Duplicated collecting system (HP:0000081)3.08143472
14Patellar aplasia (HP:0006443)3.07798610
15Pancreatic islet-cell hyperplasia (HP:0004510)2.95419445
16Medulloblastoma (HP:0002885)2.93080299
17Myelodysplasia (HP:0002863)2.92569158
18Duodenal stenosis (HP:0100867)2.92071310
19Small intestinal stenosis (HP:0012848)2.92071310
20Aplasia/Hypoplasia of the patella (HP:0006498)2.85580093
21Premature graying of hair (HP:0002216)2.84674949
22Intestinal atresia (HP:0011100)2.84069711
23Bone marrow hypocellularity (HP:0005528)2.81311927
24Ectopic kidney (HP:0000086)2.81148359
25Aplastic anemia (HP:0001915)2.80015939
26Clubbing of toes (HP:0100760)2.78218460
27Abnormality of midbrain morphology (HP:0002418)2.76437938
28Molar tooth sign on MRI (HP:0002419)2.76437938
29Rough bone trabeculation (HP:0100670)2.76153237
3011 pairs of ribs (HP:0000878)2.70593087
31Acute necrotizing encephalopathy (HP:0006965)2.70081992
32Progressive macrocephaly (HP:0004481)2.61781852
33Colon cancer (HP:0003003)2.60931946
34Acute encephalopathy (HP:0006846)2.58433300
35Absent radius (HP:0003974)2.58320153
36Abnormality of the carotid arteries (HP:0005344)2.56502745
37Sloping forehead (HP:0000340)2.56340613
38Supernumerary spleens (HP:0009799)2.54415832
39Abnormality of endocrine pancreas physiology (HP:0012093)2.53021779
40Abnormality of the pancreatic islet cells (HP:0006476)2.53021779
41Absent thumb (HP:0009777)2.52752628
42Methylmalonic acidemia (HP:0002912)2.51178089
43Aplasia involving forearm bones (HP:0009822)2.51176693
44Absent forearm bone (HP:0003953)2.51176693
45Neoplasm of the adrenal cortex (HP:0100641)2.48359992
46Abnormality of DNA repair (HP:0003254)2.48001605
47Abnormality of the labia minora (HP:0012880)2.47662112
48Hypothermia (HP:0002045)2.47460713
49Increased CSF lactate (HP:0002490)2.44823656
50Type I transferrin isoform profile (HP:0003642)2.43524087
51Oral leukoplakia (HP:0002745)2.41023607
52Abnormality of the duodenum (HP:0002246)2.39491796
53Agnosia (HP:0010524)2.38500059
54Hyperinsulinemic hypoglycemia (HP:0000825)2.36297945
55Large for gestational age (HP:0001520)2.35554528
56Medial flaring of the eyebrow (HP:0010747)2.34928632
57Nephroblastoma (Wilms tumor) (HP:0002667)2.34364337
58Abnormal number of incisors (HP:0011064)2.31654447
59Nephronophthisis (HP:0000090)2.31130278
60Abnormal lung lobation (HP:0002101)2.31100724
61Impulsivity (HP:0100710)2.29807386
62Abnormal mitochondria in muscle tissue (HP:0008316)2.29099827
63Glioma (HP:0009733)2.29016027
64Mitochondrial inheritance (HP:0001427)2.27728169
65Tracheoesophageal fistula (HP:0002575)2.27296498
66Triphalangeal thumb (HP:0001199)2.25686681
67Astrocytoma (HP:0009592)2.19808665
68Abnormality of the astrocytes (HP:0100707)2.19808665
69Embryonal renal neoplasm (HP:0011794)2.19685165
70Abnormality of methionine metabolism (HP:0010901)2.19548168
71Ketoacidosis (HP:0001993)2.13556840
72Hypoglycemic seizures (HP:0002173)2.13239615
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13098801
74Increased hepatocellular lipid droplets (HP:0006565)2.11996395
75Amaurosis fugax (HP:0100576)2.10018872
76Abnormal trabecular bone morphology (HP:0100671)2.09430000
77Optic nerve coloboma (HP:0000588)2.09115927
78Abnormality of the renal cortex (HP:0011035)2.08949916
79Lipid accumulation in hepatocytes (HP:0006561)2.08315934
80Degeneration of anterior horn cells (HP:0002398)2.08221523
81Abnormality of the anterior horn cell (HP:0006802)2.08221523
82Neoplasm of the adrenal gland (HP:0100631)2.07797358
83Methylmalonic aciduria (HP:0012120)2.07203118
84Hepatocellular necrosis (HP:0001404)2.07024924
85Cerebral hypomyelination (HP:0006808)2.06290028
86Chronic hepatic failure (HP:0100626)2.05977769
87Neoplasm of the pancreas (HP:0002894)2.05169669
88Prominent metopic ridge (HP:0005487)2.04288443
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.02632462
90Prostate neoplasm (HP:0100787)2.01516392
91Abnormality of the metopic suture (HP:0005556)2.00477559
92Lymphoma (HP:0002665)1.99599167
93Hepatic necrosis (HP:0002605)1.99327434
94Horseshoe kidney (HP:0000085)1.98611705
95Hypoglycemic coma (HP:0001325)1.97296303
96Carpal bone hypoplasia (HP:0001498)1.96993772
97True hermaphroditism (HP:0010459)1.95846708
98Increased serum lactate (HP:0002151)1.93992787
99Abnormal biliary tract physiology (HP:0012439)1.93292746
100Bile duct proliferation (HP:0001408)1.93292746
101Abnormality of the renal medulla (HP:0100957)1.92569567
102Pallor (HP:0000980)1.92537002
103Volvulus (HP:0002580)1.90594586
104Congenital primary aphakia (HP:0007707)1.90251787
105Short thumb (HP:0009778)1.88862907
106Pancytopenia (HP:0001876)1.88821026
107Cerebral edema (HP:0002181)1.87873502
108Abnormal spermatogenesis (HP:0008669)1.87615828
109Rhabdomyosarcoma (HP:0002859)1.85993793
110Sclerocornea (HP:0000647)1.84141887
111Increased nuchal translucency (HP:0010880)1.83353666
112Cellular immunodeficiency (HP:0005374)1.83085878
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.82851531
114Hypomagnesemia (HP:0002917)1.82309804
115Cystic liver disease (HP:0006706)1.81614722
116Renal cortical cysts (HP:0000803)1.81197316
117Hyperglycinemia (HP:0002154)1.80182239
118Gait imbalance (HP:0002141)1.78715783
119Congenital stationary night blindness (HP:0007642)1.78599659
120Thrombocytosis (HP:0001894)1.78432241
121Abnormality of alanine metabolism (HP:0010916)1.78310152
122Hyperalaninemia (HP:0003348)1.78310152
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78310152
124Thyroiditis (HP:0100646)1.78163316
125Cleft eyelid (HP:0000625)1.76786607
126Abnormality of vitamin B metabolism (HP:0004340)1.76638620
127Genital tract atresia (HP:0001827)1.76155375
128Gastrointestinal atresia (HP:0002589)1.76067777
129Progressive inability to walk (HP:0002505)1.76065572
130Macrocytic anemia (HP:0001972)1.75455915
131IgM deficiency (HP:0002850)1.75326521
132Oligodactyly (hands) (HP:0001180)1.74552860
133Abnormality of abdominal situs (HP:0011620)1.74267515
134Abdominal situs inversus (HP:0003363)1.74267515
135Aqueductal stenosis (HP:0002410)1.73362959
136Abnormality of the prostate (HP:0008775)1.73073392
137Furrowed tongue (HP:0000221)1.72865811
138Male pseudohermaphroditism (HP:0000037)1.72311102
139Septo-optic dysplasia (HP:0100842)1.71940383
140Dandy-Walker malformation (HP:0001305)1.71564843
141Nephrogenic diabetes insipidus (HP:0009806)1.70816400
142Abnormal number of erythroid precursors (HP:0012131)1.70604779
143Postaxial foot polydactyly (HP:0001830)1.69982928
144Ependymoma (HP:0002888)1.69879623
145Breast carcinoma (HP:0003002)1.69677122
146Anencephaly (HP:0002323)1.69434848
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.69423772
148Hypoplasia of the fovea (HP:0007750)1.69423772
149Aplasia/Hypoplasia of the earlobes (HP:0009906)1.68068297
150Facial cleft (HP:0002006)1.67943265
151Pancreatic cysts (HP:0001737)1.67560397
152Pancreatic fibrosis (HP:0100732)1.65844807
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65245519
154Aseptic necrosis (HP:0010885)1.64951084
155Atresia of the external auditory canal (HP:0000413)1.64660172
156Pulmonary fibrosis (HP:0002206)1.64160676
157Abnormality of cells of the erythroid lineage (HP:0012130)1.63509627
158Hypergonadotropic hypogonadism (HP:0000815)1.63433890
159Homocystinuria (HP:0002156)1.63341500
160Abnormality of homocysteine metabolism (HP:0010919)1.63341500
161Preaxial hand polydactyly (HP:0001177)1.62329991
162Abnormality of the columella (HP:0009929)1.61946326
163Asplenia (HP:0001746)1.60576543
164Median cleft lip (HP:0000161)1.59646232
165Breast aplasia (HP:0100783)1.58165877
166Cafe-au-lait spot (HP:0000957)1.57779545
167Abnormality of pyrimidine metabolism (HP:0004353)1.55040313
168Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.54610680
169Poikiloderma (HP:0001029)1.54460941
170Short middle phalanx of the 5th finger (HP:0004220)1.54383633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.16336031
2BUB14.04248426
3CDC73.91396722
4FRK3.73546968
5TRIM283.35075950
6SRPK12.92814310
7MST42.83531027
8PLK42.82143023
9STK162.77309737
10MKNK22.60730245
11MKNK12.58891487
12TTK2.49364162
13BRSK22.44113035
14ZAK2.43412555
15EIF2AK12.29790059
16TSSK62.26089554
17ACVR1B2.22785525
18PLK12.04800517
19NEK22.00933481
20ATR1.95800931
21VRK21.91497343
22VRK11.81008249
23EPHA21.79427335
24BRD41.76773436
25PLK31.72797922
26TLK11.72610821
27MAP4K21.66805338
28BCR1.63575469
29CDK71.58866786
30EIF2AK31.58814035
31CHEK21.52240421
32GRK11.52135688
33WNK41.48545803
34DYRK31.47623739
35AURKB1.45952671
36PASK1.45484643
37EIF2AK21.42108006
38STK391.41684765
39CDK121.41588573
40IRAK41.38399271
41CCNB11.37078971
42RPS6KB21.34770061
43BRSK11.32020932
44TXK1.25087204
45FGFR21.23291475
46NEK91.23205130
47TAF11.21375048
48PDK21.21119783
49PINK11.19181512
50IRAK31.15651307
51TGFBR11.15521809
52CDK41.12747876
53CHEK11.11410266
54AURKA1.11002429
55NEK11.07771518
56CSNK1G11.07451180
57STK101.06294802
58OXSR11.04280272
59ATM1.03884687
60INSRR1.00781161
61NME10.99637787
62PIM20.98723819
63YES10.98169565
64CSNK1G30.94385812
65TESK20.93526203
66STK38L0.93380924
67AKT30.93079172
68MAP3K80.91024529
69STK40.90699381
70PNCK0.87074768
71CDK80.84603419
72CSNK1G20.82635436
73MAP3K40.81760794
74ERBB30.81650085
75PIM10.79819784
76RPS6KA40.79274187
77CSNK1A1L0.78742409
78CDK20.77290345
79MAPK130.75720571
80MELK0.72526258
81CLK10.71805100
82NME20.71646668
83JAK30.70382893
84PAK40.67639987
85CDK10.65784800
86DYRK20.65624103
87NLK0.62771898
88RPS6KA50.62544604
89PAK30.61500389
90FLT30.60660240
91ERBB40.59365502
92BRAF0.58642739
93BMPR1B0.58427899
94TEC0.58125555
95CSNK2A10.56763281
96TNIK0.55262035
97BTK0.54959169
98PRKCE0.53205936
99CSNK2A20.50895843
100MAP3K140.50818190
101PRKCI0.46610870
102PBK0.45458745
103STK30.45234424
104IKBKB0.43335821
105PRKCG0.43074777
106CDK30.42564945
107NUAK10.42463183
108NEK60.41960398
109KSR10.41540348
110CHUK0.40921565
111MAPKAPK50.39553959
112KIT0.39512190
113CDK60.38818155
114TAOK20.38066196
115ALK0.36533587
116TAOK30.34782903
117ADRBK20.34632136
118FER0.34309620
119PRKDC0.33680801
120PAK10.33027862
121FGFR10.32851972
122CASK0.32441472
123CDK90.32434392
124PLK20.31016959
125MARK30.30043089
126CSNK1E0.29671491
127WNK30.29544586
128CSNK1A10.29168762
129DAPK10.28952463
130PHKG20.28853970
131PHKG10.28853970
132STK240.28528337
133LYN0.28216714
134MAPK140.28134622
135RAF10.27541170
136AKT10.27203695
137MINK10.25054514
138SIK30.24728959
139RPS6KB10.24019270
140NTRK30.23592248
141MAPKAPK30.22494694
142MAP4K10.21486190
143ZAP700.20758880

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.56116405
2Mismatch repair_Homo sapiens_hsa034304.02092200
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41397140
4Homologous recombination_Homo sapiens_hsa034403.24187477
5RNA polymerase_Homo sapiens_hsa030203.14135512
6Base excision repair_Homo sapiens_hsa034103.04253454
7Spliceosome_Homo sapiens_hsa030403.04091020
8Fanconi anemia pathway_Homo sapiens_hsa034603.01973214
9Cell cycle_Homo sapiens_hsa041102.86863812
10RNA transport_Homo sapiens_hsa030132.75059928
11Nucleotide excision repair_Homo sapiens_hsa034202.68421987
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66551269
13One carbon pool by folate_Homo sapiens_hsa006702.63371437
14Non-homologous end-joining_Homo sapiens_hsa034502.48082205
15Ribosome_Homo sapiens_hsa030102.44844324
16Proteasome_Homo sapiens_hsa030502.44596192
17Pyrimidine metabolism_Homo sapiens_hsa002402.30017453
18Basal transcription factors_Homo sapiens_hsa030222.27294924
19Propanoate metabolism_Homo sapiens_hsa006402.18886527
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15998594
21Butanoate metabolism_Homo sapiens_hsa006501.99120017
22RNA degradation_Homo sapiens_hsa030181.93480695
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91794927
24Oxidative phosphorylation_Homo sapiens_hsa001901.89833193
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.86554719
26mRNA surveillance pathway_Homo sapiens_hsa030151.85809531
27Steroid biosynthesis_Homo sapiens_hsa001001.82523269
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82466662
29p53 signaling pathway_Homo sapiens_hsa041151.80893380
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72495124
31Parkinsons disease_Homo sapiens_hsa050121.53383346
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47212940
33Fatty acid elongation_Homo sapiens_hsa000621.41906608
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33778838
35Purine metabolism_Homo sapiens_hsa002301.30992061
36Epstein-Barr virus infection_Homo sapiens_hsa051691.28492878
37Systemic lupus erythematosus_Homo sapiens_hsa053221.27980165
38Herpes simplex infection_Homo sapiens_hsa051681.23450872
39Phototransduction_Homo sapiens_hsa047441.20739204
40Pyruvate metabolism_Homo sapiens_hsa006201.18020067
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09603877
42Huntingtons disease_Homo sapiens_hsa050161.08492107
43Nitrogen metabolism_Homo sapiens_hsa009101.04951817
44Viral carcinogenesis_Homo sapiens_hsa052031.00568214
45Peroxisome_Homo sapiens_hsa041460.96154814
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95151266
47Antigen processing and presentation_Homo sapiens_hsa046120.94344579
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93375084
49Tryptophan metabolism_Homo sapiens_hsa003800.92607966
50Oocyte meiosis_Homo sapiens_hsa041140.89198444
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88452557
52Fatty acid metabolism_Homo sapiens_hsa012120.87286913
53HTLV-I infection_Homo sapiens_hsa051660.85864783
54Alzheimers disease_Homo sapiens_hsa050100.83800522
55Primary immunodeficiency_Homo sapiens_hsa053400.83193119
56Measles_Homo sapiens_hsa051620.81452241
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81406143
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.79012327
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77689110
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76781665
61Allograft rejection_Homo sapiens_hsa053300.75748971
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74249031
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74177194
64Metabolic pathways_Homo sapiens_hsa011000.73041000
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71315865
66Caffeine metabolism_Homo sapiens_hsa002320.70849344
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70541518
68Vitamin B6 metabolism_Homo sapiens_hsa007500.69824406
69MicroRNAs in cancer_Homo sapiens_hsa052060.67886570
70Autoimmune thyroid disease_Homo sapiens_hsa053200.67315030
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65508276
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.65025953
73Legionellosis_Homo sapiens_hsa051340.62776424
74Graft-versus-host disease_Homo sapiens_hsa053320.62295448
75Ether lipid metabolism_Homo sapiens_hsa005650.61997157
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61708512
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61329772
78Hematopoietic cell lineage_Homo sapiens_hsa046400.59394417
79Regulation of autophagy_Homo sapiens_hsa041400.58954052
80Carbon metabolism_Homo sapiens_hsa012000.58307541
81beta-Alanine metabolism_Homo sapiens_hsa004100.57752805
82Olfactory transduction_Homo sapiens_hsa047400.56452589
83Fatty acid degradation_Homo sapiens_hsa000710.56293675
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56226813
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55273020
86Influenza A_Homo sapiens_hsa051640.55056629
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54742815
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54619885
89Colorectal cancer_Homo sapiens_hsa052100.54388606
90Sulfur metabolism_Homo sapiens_hsa009200.54244071
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.53005216
92Basal cell carcinoma_Homo sapiens_hsa052170.52813032
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51575069
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51496512
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50694278
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50561849
97Notch signaling pathway_Homo sapiens_hsa043300.50345751
98TGF-beta signaling pathway_Homo sapiens_hsa043500.49511008
99Apoptosis_Homo sapiens_hsa042100.49500711
100Collecting duct acid secretion_Homo sapiens_hsa049660.49305514
101Circadian rhythm_Homo sapiens_hsa047100.49259947
102Small cell lung cancer_Homo sapiens_hsa052220.49067133
103Protein export_Homo sapiens_hsa030600.48124662
104N-Glycan biosynthesis_Homo sapiens_hsa005100.48037101
105Asthma_Homo sapiens_hsa053100.47860603
106Hepatitis B_Homo sapiens_hsa051610.46570599
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44953616
108Shigellosis_Homo sapiens_hsa051310.43992576
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43825063
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43747606
111Lysine degradation_Homo sapiens_hsa003100.42947565
112Retinol metabolism_Homo sapiens_hsa008300.42745739
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41905996
114Alcoholism_Homo sapiens_hsa050340.41845415
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41673236
116Pentose phosphate pathway_Homo sapiens_hsa000300.41458274
117Hippo signaling pathway_Homo sapiens_hsa043900.41199374
118Arachidonic acid metabolism_Homo sapiens_hsa005900.38636801
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.37674698
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.37113234
121Leishmaniasis_Homo sapiens_hsa051400.35912945
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35322087
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34698083
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33162656
125Selenocompound metabolism_Homo sapiens_hsa004500.32350245
126Biosynthesis of amino acids_Homo sapiens_hsa012300.31402947
127Wnt signaling pathway_Homo sapiens_hsa043100.31395087
128Thyroid cancer_Homo sapiens_hsa052160.30899876
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30828738
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.30572697
131Pathways in cancer_Homo sapiens_hsa052000.30492142
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.29618689
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.29378792
134Viral myocarditis_Homo sapiens_hsa054160.26881688
135Chemical carcinogenesis_Homo sapiens_hsa052040.26048091
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25592320
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25426721
138Hedgehog signaling pathway_Homo sapiens_hsa043400.25281732
139Folate biosynthesis_Homo sapiens_hsa007900.24928133
140Other glycan degradation_Homo sapiens_hsa005110.24305100
141Arginine and proline metabolism_Homo sapiens_hsa003300.23852712
142T cell receptor signaling pathway_Homo sapiens_hsa046600.23075231
143Adherens junction_Homo sapiens_hsa045200.22187132
144Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21978845
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21771549
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21212069
147Type I diabetes mellitus_Homo sapiens_hsa049400.20309161
148Acute myeloid leukemia_Homo sapiens_hsa052210.20023836
149Prostate cancer_Homo sapiens_hsa052150.18203204
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18106066
151Toxoplasmosis_Homo sapiens_hsa051450.18064308
152Glutathione metabolism_Homo sapiens_hsa004800.17866619
153Melanoma_Homo sapiens_hsa052180.17017277
154FoxO signaling pathway_Homo sapiens_hsa040680.16753481
155Sphingolipid metabolism_Homo sapiens_hsa006000.16213662
156TNF signaling pathway_Homo sapiens_hsa046680.15583634
157Linoleic acid metabolism_Homo sapiens_hsa005910.14754258

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